PDC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal rod cell development (GO:0046548)9.96192716
2phototransduction, visible light (GO:0007603)9.88683826
3GMP metabolic process (GO:0046037)9.69780498
4regulation of guanylate cyclase activity (GO:0031282)9.55333980
5* detection of light stimulus (GO:0009583)9.53910513
6detection of visible light (GO:0009584)9.38873258
7* visual perception (GO:0007601)8.28896285
8* sensory perception of light stimulus (GO:0050953)8.19183808
9eye photoreceptor cell differentiation (GO:0001754)8.08873822
10photoreceptor cell differentiation (GO:0046530)8.08873822
11cellular response to light stimulus (GO:0071482)7.22118913
12regulation of cGMP metabolic process (GO:0030823)6.95922280
13retina development in camera-type eye (GO:0060041)6.72056872
14* detection of external stimulus (GO:0009581)6.63737378
15protein-chromophore linkage (GO:0018298)6.60138846
16* detection of abiotic stimulus (GO:0009582)6.50737561
17positive regulation of cGMP biosynthetic process (GO:0030828)6.20298578
18regulation of cGMP biosynthetic process (GO:0030826)5.82960181
19positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.73207532
20cell morphogenesis involved in neuron differentiation (GO:0048667)5.68535045
21neuron fate determination (GO:0048664)5.56632515
22detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)5.48143658
23positive regulation of cGMP metabolic process (GO:0030825)5.47962403
24negative regulation of cytosolic calcium ion concentration (GO:0051481)5.40186471
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.39464290
26receptor guanylyl cyclase signaling pathway (GO:0007168)5.35726339
27gonadal mesoderm development (GO:0007506)5.30606408
28alanine transport (GO:0032328)5.06117981
29positive regulation of male gonad development (GO:2000020)4.80806730
30regulation of voltage-gated calcium channel activity (GO:1901385)4.73865457
31nonmotile primary cilium assembly (GO:0035058)4.67417667
32cellular response to radiation (GO:0071478)4.62847455
33regulation of male gonad development (GO:2000018)4.61630321
34spinal cord association neuron differentiation (GO:0021527)4.59651943
35short-term memory (GO:0007614)4.37381922
36retina homeostasis (GO:0001895)4.29292620
37retinal ganglion cell axon guidance (GO:0031290)4.26669164
38positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.23304465
39regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.21609345
40prenylation (GO:0097354)4.14456473
41protein prenylation (GO:0018342)4.14456473
42regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.08564588
43regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.08564588
44regulation of penile erection (GO:0060405)4.08036477
45proline transport (GO:0015824)4.05642806
46regulation of female gonad development (GO:2000194)4.03108113
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.00419790
48regulation of clathrin-mediated endocytosis (GO:2000369)3.98458424
49chemosensory behavior (GO:0007635)3.96216071
50negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.91896888
51glutamate receptor signaling pathway (GO:0007215)3.90612224
52* sensory perception (GO:0007600)3.87393858
53behavioral response to ethanol (GO:0048149)3.81542288
54neuron development (GO:0048666)3.81168928
55embryonic retina morphogenesis in camera-type eye (GO:0060059)3.78468224
56response to histamine (GO:0034776)3.73310544
57adaptation of signaling pathway (GO:0023058)3.72149032
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.66505671
59opioid receptor signaling pathway (GO:0038003)3.65921926
60* response to light stimulus (GO:0009416)3.63377751
61positive regulation of sodium ion transmembrane transport (GO:1902307)3.61864409
62transepithelial transport (GO:0070633)3.57550375
63ventricular septum morphogenesis (GO:0060412)3.56993658
64positive regulation of cell cycle checkpoint (GO:1901978)3.56120754
65ionotropic glutamate receptor signaling pathway (GO:0035235)3.45105518
66negative regulation of receptor-mediated endocytosis (GO:0048261)3.44564516
67protein heterotetramerization (GO:0051290)3.44332259
68pyrimidine nucleobase catabolic process (GO:0006208)3.43311489
69negative regulation of cell aging (GO:0090344)3.39329004
70genitalia morphogenesis (GO:0035112)3.36179219
71neuroblast proliferation (GO:0007405)3.34580284
72histone mRNA catabolic process (GO:0071044)3.33499867
73positive regulation of neurotransmitter transport (GO:0051590)3.31825360
74nephron tubule morphogenesis (GO:0072078)3.29641114
75nephron epithelium morphogenesis (GO:0072088)3.29641114
76neural tube formation (GO:0001841)3.28398214
77peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.19956312
78negative regulation of astrocyte differentiation (GO:0048712)3.19329642
79behavioral response to cocaine (GO:0048148)3.11885898
80retina layer formation (GO:0010842)3.11874953
81positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.11521507
82cellular response to ATP (GO:0071318)3.10969712
83membrane hyperpolarization (GO:0060081)3.10324745
84response to pheromone (GO:0019236)3.07991206
85synaptic transmission, dopaminergic (GO:0001963)3.07567945
86detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.07210949
87ectodermal placode formation (GO:0060788)3.04442101
88post-embryonic morphogenesis (GO:0009886)3.03139456
89renal tubule morphogenesis (GO:0061333)3.02859642
90icosanoid secretion (GO:0032309)3.02187887
91arachidonic acid secretion (GO:0050482)3.02187887
92calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.01007692
93primitive streak formation (GO:0090009)3.00566666
94protein localization to synapse (GO:0035418)3.00416519
95hair cell differentiation (GO:0035315)3.00077715
96appendage development (GO:0048736)2.99177028
97limb development (GO:0060173)2.99177028
98positive regulation of embryonic development (GO:0040019)2.98976488
99negative regulation of cation channel activity (GO:2001258)2.98739277
100neuron recognition (GO:0008038)2.97020741
101negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.95206149
102negative regulation of calcium ion transmembrane transport (GO:1903170)2.95206149
103hindbrain development (GO:0030902)2.94776292
104intraciliary transport (GO:0042073)2.91198541
105regulation of axon regeneration (GO:0048679)2.91159992
106regulation of neuron projection regeneration (GO:0070570)2.91159992
107central nervous system projection neuron axonogenesis (GO:0021952)2.91099924
108regulation of short-term neuronal synaptic plasticity (GO:0048172)2.87956160
109cell differentiation involved in metanephros development (GO:0072202)2.86139807
110acidic amino acid transport (GO:0015800)2.85869589
111cell differentiation in spinal cord (GO:0021515)2.84745253
112nucleobase catabolic process (GO:0046113)2.84124198
113synapse assembly (GO:0007416)2.83393430
114regulation of neurotransmitter uptake (GO:0051580)2.81805381
115detection of chemical stimulus involved in sensory perception (GO:0050907)2.78693432
116neurotransmitter-gated ion channel clustering (GO:0072578)2.78150582
117sensory perception of smell (GO:0007608)2.77633880
118L-glutamate transport (GO:0015813)2.77578444
119negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.76866418
120activated T cell proliferation (GO:0050798)2.75597629
121outflow tract septum morphogenesis (GO:0003148)2.75003298
122neuronal stem cell maintenance (GO:0097150)2.74582879
123homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.74074413
124regulation of cAMP-dependent protein kinase activity (GO:2000479)2.73931956
125glycine transport (GO:0015816)2.73161850
126radial glial cell differentiation (GO:0060019)2.72674469
127retinol metabolic process (GO:0042572)2.72328201
128dopamine receptor signaling pathway (GO:0007212)2.71624395
129nerve growth factor signaling pathway (GO:0038180)2.70427970
130lipoprotein transport (GO:0042953)2.70388174
131estrogen biosynthetic process (GO:0006703)2.67480442
132response to nitrosative stress (GO:0051409)2.67329875
133regulation of catecholamine metabolic process (GO:0042069)2.66218324
134regulation of dopamine metabolic process (GO:0042053)2.66218324
135positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.66044457
136presynaptic membrane organization (GO:0097090)2.65796596
137synaptic vesicle exocytosis (GO:0016079)2.64662694
138positive regulation of gastrulation (GO:2000543)2.62488514
139positive regulation of membrane potential (GO:0045838)2.62032227
140regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.61985542
141regulation of sarcomere organization (GO:0060297)2.60138428
142negative regulation of glial cell differentiation (GO:0045686)2.60108210
143retinoid metabolic process (GO:0001523)2.58299639
144synaptic vesicle maturation (GO:0016188)2.54258722
145positive regulation of cyclase activity (GO:0031281)2.54254424
146negative regulation of meiosis (GO:0045835)2.53108651
147epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53056660
148G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.50648899
149layer formation in cerebral cortex (GO:0021819)2.50386717
150* response to radiation (GO:0009314)2.50372842
151somite rostral/caudal axis specification (GO:0032525)2.48602551
152central nervous system neuron axonogenesis (GO:0021955)2.47691473
153neuron-neuron synaptic transmission (GO:0007270)2.47638786
154dorsal/ventral axis specification (GO:0009950)2.47230131
155synaptic transmission, glutamatergic (GO:0035249)2.46333058
156presynaptic membrane assembly (GO:0097105)2.45733943
157icosanoid transport (GO:0071715)2.45359430
158fatty acid derivative transport (GO:1901571)2.45359430
159glial cell proliferation (GO:0014009)2.45357347
160cilium or flagellum-dependent cell motility (GO:0001539)2.44926840
161cellular response to electrical stimulus (GO:0071257)2.44744938
162CDP-diacylglycerol biosynthetic process (GO:0016024)2.42050798
163positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.40712579
164sensory perception of chemical stimulus (GO:0007606)2.40280097
165diterpenoid metabolic process (GO:0016101)2.38810689
166phospholipid translocation (GO:0045332)2.38717843
167lipid translocation (GO:0034204)2.38717843
168regulation of synaptic transmission, dopaminergic (GO:0032225)2.36734449
169CDP-diacylglycerol metabolic process (GO:0046341)2.31957130
170striatum development (GO:0021756)2.31735092
171regulation of rhodopsin mediated signaling pathway (GO:0022400)17.8232474
172rhodopsin mediated signaling pathway (GO:0016056)17.1474765
173retinal cone cell development (GO:0046549)15.7682017
174photoreceptor cell development (GO:0042461)12.7438039
175eye photoreceptor cell development (GO:0042462)12.1853087
176photoreceptor cell maintenance (GO:0045494)11.5902505
177positive regulation of guanylate cyclase activity (GO:0031284)10.5604663
178detection of light stimulus involved in sensory perception (GO:0050962)10.2775981
179detection of light stimulus involved in visual perception (GO:0050908)10.2775981
180* phototransduction (GO:0007602)10.0219768

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.06926056
2VDR_22108803_ChIP-Seq_LS180_Human4.70700036
3CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.11612656
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.58016502
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.31082045
6EZH2_22144423_ChIP-Seq_EOC_Human2.67545448
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.55371512
8FUS_26573619_Chip-Seq_HEK293_Human2.50394149
9* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48334284
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.45385752
11DROSHA_22980978_ChIP-Seq_HELA_Human2.33203892
12TAF15_26573619_Chip-Seq_HEK293_Human2.30241669
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28313571
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23396836
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15546621
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15042144
17P300_19829295_ChIP-Seq_ESCs_Human2.10886013
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02391135
19BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.01109316
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95221150
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.94040861
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93966045
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91987016
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.88382754
25IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.87957426
26CBP_20019798_ChIP-Seq_JUKART_Human1.87957426
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87411382
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.86056192
29SMAD3_21741376_ChIP-Seq_EPCs_Human1.83536719
30* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.82971382
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80635078
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79408942
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.76168717
34KDM2B_26808549_Chip-Seq_K562_Human1.75555199
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71434606
36* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71292678
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71214290
38* EWS_26573619_Chip-Seq_HEK293_Human1.70729211
39GBX2_23144817_ChIP-Seq_PC3_Human1.70452934
40AR_25329375_ChIP-Seq_VCAP_Human1.68559000
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.68483130
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.66904008
43* NFE2_27457419_Chip-Seq_LIVER_Mouse1.65490105
44CTCF_27219007_Chip-Seq_Bcells_Human1.64408530
45STAT3_23295773_ChIP-Seq_U87_Human1.64265176
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.63366863
47* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62515078
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62044217
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60705076
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60243479
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60062638
52* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.59856370
53SMAD3_21741376_ChIP-Seq_HESCs_Human1.57643997
54* EZH2_27294783_Chip-Seq_NPCs_Mouse1.57176778
55* NANOG_18555785_Chip-Seq_ESCs_Mouse1.57073643
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56755140
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55269327
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55269327
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54789557
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54789557
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54735591
62SMC4_20622854_ChIP-Seq_HELA_Human1.54717478
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53939032
64RNF2_27304074_Chip-Seq_NSC_Mouse1.53346587
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53321233
66REST_21632747_ChIP-Seq_MESCs_Mouse1.53222708
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50147084
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47154519
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.46918553
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.45451637
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43819000
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41963960
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41375862
74* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.41226293
75PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.40303644
76AR_19668381_ChIP-Seq_PC3_Human1.40167554
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39979889
78KDM2B_26808549_Chip-Seq_REH_Human1.39884866
79* P53_22387025_ChIP-Seq_ESCs_Mouse1.38878786
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.38779630
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38287587
82TCF4_23295773_ChIP-Seq_U87_Human1.38155070
83RARB_27405468_Chip-Seq_BRAIN_Mouse1.37809916
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.37614137
85ER_23166858_ChIP-Seq_MCF-7_Human1.35760762
86* E2F1_18555785_Chip-Seq_ESCs_Mouse1.34945556
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34547461
88CTCF_20526341_ChIP-Seq_ESCs_Human1.33952076
89CBX2_22325352_ChIP-Seq_293T-Rex_Human1.32305793
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.31968039
91ETV1_20927104_ChIP-Seq_GIST48_Human1.31043637
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30087428
93* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28214455
94* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28214455
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.28194401
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27695988
97ERG_20517297_ChIP-Seq_VCAP_Human1.26679670
98TAF2_19829295_ChIP-Seq_ESCs_Human1.25062099
99* CMYC_18555785_Chip-Seq_ESCs_Mouse1.24691458
100KDM2B_26808549_Chip-Seq_JURKAT_Human1.24555399
101SA1_27219007_Chip-Seq_Bcells_Human1.24307309
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.24230666
103ELK4_26923725_Chip-Seq_MESODERM_Mouse1.23612171
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23506063
105* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22688838
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22409552
107IGF1R_20145208_ChIP-Seq_DFB_Human1.22253236
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22230129
109NCOR_22424771_ChIP-Seq_293T_Human1.19851166
110NFYB_21822215_ChIP-Seq_K562_Human1.19695031
111NFYA_21822215_ChIP-Seq_K562_Human1.19544065
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17307116
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17132584
114MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16388965
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15809424
116BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15593162
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15516809
118* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15418415
119CREB1_26743006_Chip-Seq_LNCaP_Human1.15406486
120* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14988674
121CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13795193
122SALL1_21062744_ChIP-ChIP_HESCs_Human1.13406401
123* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13235363
124P68_20966046_ChIP-Seq_HELA_Human1.12706100
125* RUNX2_22187159_ChIP-Seq_PCA_Human1.12657816
126BCAT_22108803_ChIP-Seq_LS180_Human1.12462943
127LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12214062
128AR_21572438_ChIP-Seq_LNCaP_Human1.12073128
129* PHF8_20622853_ChIP-Seq_HELA_Human1.11438026
130ZNF274_21170338_ChIP-Seq_K562_Hela1.11329651
131STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11026291
132JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09431216
133* P300_18555785_Chip-Seq_ESCs_Mouse1.09345748
134WDR5_24793694_ChIP-Seq_LNCAP_Human1.08517066
135TBL1_22424771_ChIP-Seq_293T_Human1.07995821
136KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06413566
137OCT4_19829295_ChIP-Seq_ESCs_Human1.01878785
138RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00177045
139SMAD4_21799915_ChIP-Seq_A2780_Human0.99540358
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97819056
141EED_16625203_ChIP-ChIP_MESCs_Mouse0.97271600
142LXR_22292898_ChIP-Seq_THP-1_Human0.97033790
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.96978422
144CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96740106
145RING1B_27294783_Chip-Seq_ESCs_Mouse0.96197625
146EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94609609
147RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92960338
148KDM2B_26808549_Chip-Seq_DND41_Human0.92429315
149CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91898244
150SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89137272
151GATA1_26923725_Chip-Seq_HPCs_Mouse0.87810965
152CBP_21632823_ChIP-Seq_H3396_Human0.87628265
153DPY_21335234_ChIP-Seq_ESCs_Mouse0.85641737
154SMAD4_21741376_ChIP-Seq_ESCs_Human0.84744242
155BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84523291
156GATA2_21666600_ChIP-Seq_HMVEC_Human0.83500721
157TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83490073
158YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83172750
159THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83134362
160OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82167286
161DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81620290
162GATA1_19941827_ChIP-Seq_MEL_Mouse0.81566527
163P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.81234051
164TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81063439
165GF1_26923725_Chip-Seq_HPCs_Mouse0.80313095
166EGR1_19032775_ChIP-ChIP_M12_Human0.80218604
167NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80194079
168E2F1_17053090_ChIP-ChIP_MCF-7_Human0.79750334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog9.83705407
2MP0006072_abnormal_retinal_apoptosis6.58362828
3* MP0005253_abnormal_eye_physiology6.54857574
4MP0002822_catalepsy4.39863361
5MP0005195_abnormal_posterior_eye4.02485198
6MP0002163_abnormal_gland_morphology4.02180596
7MP0003950_abnormal_plasma_membrane3.89656447
8MP0001986_abnormal_taste_sensitivity3.48257247
9MP0001324_abnormal_eye_pigmentation3.45320929
10MP0005423_abnormal_somatic_nervous3.29330251
11* MP0005391_vision/eye_phenotype3.18444517
12MP0002638_abnormal_pupillary_reflex3.07485527
13MP0002229_neurodegeneration2.51563884
14MP0005379_endocrine/exocrine_gland_phen2.46862326
15MP0002090_abnormal_vision2.39780658
16MP0001346_abnormal_lacrimal_gland2.27164573
17MP0002138_abnormal_hepatobiliary_system2.13921856
18MP0003195_calcinosis2.03902943
19MP0001188_hyperpigmentation2.01565434
20MP0003011_delayed_dark_adaptation10.5773139
21MP0002752_abnormal_somatic_nervous1.98507199
22MP0001764_abnormal_homeostasis1.93127870
23MP0002909_abnormal_adrenal_gland1.48787908
24MP0010234_abnormal_vibrissa_follicle1.45091064
25MP0003879_abnormal_hair_cell1.43743614
26MP0002882_abnormal_neuron_morphology1.42088721
27MP0003300_gastrointestinal_ulcer1.38573420
28MP0006276_abnormal_autonomic_nervous1.38477557
29MP0005646_abnormal_pituitary_gland1.33738618
30MP0002653_abnormal_ependyma_morphology1.33688633
31MP0005220_abnormal_exocrine_pancreas1.32000992
32MP0002233_abnormal_nose_morphology1.29223711
33MP0005394_taste/olfaction_phenotype1.24603850
34MP0005499_abnormal_olfactory_system1.24603850
35MP0008057_abnormal_DNA_replication1.21883492
36MP0003567_abnormal_fetal_cardiomyocyte1.21040650
37MP0008789_abnormal_olfactory_epithelium1.19359994
38MP0001440_abnormal_grooming_behavior1.19287364
39MP0001529_abnormal_vocalization1.18378228
40MP0001984_abnormal_olfaction1.17845940
41MP0004885_abnormal_endolymph1.15181608
42MP0002938_white_spotting1.14108400
43MP0001502_abnormal_circadian_rhythm1.13603077
44MP0002735_abnormal_chemical_nociception1.13250617
45MP0004019_abnormal_vitamin_homeostasis1.11659732
46MP0006292_abnormal_olfactory_placode1.08592666
47MP0003136_yellow_coat_color1.07420066
48MP0000569_abnormal_digit_pigmentation1.04242181
49MP0002736_abnormal_nociception_after1.01757400
50MP0001919_abnormal_reproductive_system0.98801504
51MP0000566_synostosis0.98681394
52MP0005187_abnormal_penis_morphology0.98201870
53MP0002876_abnormal_thyroid_physiology0.94099405
54MP0002332_abnormal_exercise_endurance0.93749953
55MP0003937_abnormal_limbs/digits/tail_de0.88153067
56MP0003634_abnormal_glial_cell0.85183687
57MP0001970_abnormal_pain_threshold0.83136525
58MP0004270_analgesia0.81126077
59MP0001485_abnormal_pinna_reflex0.80510504
60MP0004233_abnormal_muscle_weight0.75622548
61MP0003787_abnormal_imprinting0.74629199
62MP0001944_abnormal_pancreas_morphology0.74254913
63MP0001299_abnormal_eye_distance/0.73606454
64MP0003878_abnormal_ear_physiology0.69401889
65MP0005377_hearing/vestibular/ear_phenot0.69401889
66MP0003943_abnormal_hepatobiliary_system0.67396327
67MP0004133_heterotaxia0.67085833
68MP0002132_abnormal_respiratory_system0.66857171
69* MP0002272_abnormal_nervous_system0.66627762
70MP0003880_abnormal_central_pattern0.63819952
71MP0004145_abnormal_muscle_electrophysio0.63697358
72MP0001486_abnormal_startle_reflex0.62784223
73MP0004859_abnormal_synaptic_plasticity0.60034699
74* MP0005197_abnormal_uvea_morphology0.59778193
75MP0002734_abnormal_mechanical_nocicepti0.57823170
76MP0004782_abnormal_surfactant_physiolog0.53423698
77MP0001286_abnormal_eye_development0.51762570
78MP0002064_seizures0.51133032
79MP0003635_abnormal_synaptic_transmissio0.49871391
80MP0009046_muscle_twitch0.46944323
81MP0010030_abnormal_orbit_morphology0.46703572
82MP0003045_fibrosis0.44983566
83MP0000751_myopathy0.43356810
84MP0005248_abnormal_Harderian_gland0.43188893
85MP0004215_abnormal_myocardial_fiber0.42394750
86MP0005376_homeostasis/metabolism_phenot0.42274885
87MP0004142_abnormal_muscle_tone0.41856963
88MP0001963_abnormal_hearing_physiology0.40156620
89MP0002063_abnormal_learning/memory/cond0.39740765
90MP0002067_abnormal_sensory_capabilities0.39239788
91MP0001661_extended_life_span0.38823056
92MP0009745_abnormal_behavioral_response0.37838750
93MP0004043_abnormal_pH_regulation0.35515971
94MP0002572_abnormal_emotion/affect_behav0.35171186
95MP0001905_abnormal_dopamine_level0.34064487
96MP0000631_abnormal_neuroendocrine_gland0.33838454
97MP0002234_abnormal_pharynx_morphology0.32046222
98MP0002697_abnormal_eye_size0.31289633
99MP0004811_abnormal_neuron_physiology0.30165126
100MP0002108_abnormal_muscle_morphology0.29149789
101MP0003646_muscle_fatigue0.28605846
102MP0000465_gastrointestinal_hemorrhage0.28440870
103MP0004924_abnormal_behavior0.26463070
104MP0005386_behavior/neurological_phenoty0.26463070
105MP0002152_abnormal_brain_morphology0.24432102
106MP0005076_abnormal_cell_differentiation0.24009901
107MP0001968_abnormal_touch/_nociception0.23347693
108MP0004084_abnormal_cardiac_muscle0.22953022
109MP0002089_abnormal_postnatal_growth/wei0.22630808
110MP0000026_abnormal_inner_ear0.22255001
111MP0002184_abnormal_innervation0.21569156
112MP0001177_atelectasis0.21306581
113MP0002066_abnormal_motor_capabilities/c0.21210550
114MP0003252_abnormal_bile_duct0.20856379
115MP0005084_abnormal_gallbladder_morpholo0.20767329
116MP0002168_other_aberrant_phenotype0.19761873
117MP0003633_abnormal_nervous_system0.19577169
118MP0003890_abnormal_embryonic-extraembry0.18889724
119MP0008569_lethality_at_weaning0.18543664
120MP0008775_abnormal_heart_ventricle0.18399229
121MP0009780_abnormal_chondrocyte_physiolo0.18121204
122MP0008058_abnormal_DNA_repair0.17780916
123* MP0002127_abnormal_cardiovascular_syste0.17433161
124MP0003632_abnormal_nervous_system0.16843520
125* MP0005620_abnormal_muscle_contractility0.16776206
126MP0004036_abnormal_muscle_relaxation0.16193562
127MP0000955_abnormal_spinal_cord0.15034062
128MP0002557_abnormal_social/conspecific_i0.14778732
129MP0002928_abnormal_bile_duct0.14675518
130MP0003329_amyloid_beta_deposits0.14184591
131MP0000778_abnormal_nervous_system0.13597328
132MP0004742_abnormal_vestibular_system0.13596574
133MP0001915_intracranial_hemorrhage0.13422413
134MP0010386_abnormal_urinary_bladder0.13128870
135MP0003631_nervous_system_phenotype0.12609727
136MP0005330_cardiomyopathy0.12549610
137MP0001501_abnormal_sleep_pattern0.12330637
138* MP0005193_abnormal_anterior_eye0.12268098

Predicted human phenotypes

RankGene SetZ-score
1Chorioretinal atrophy (HP:0000533)9.12042515
2Pendular nystagmus (HP:0012043)8.07300339
3Attenuation of retinal blood vessels (HP:0007843)7.39008499
4Central scotoma (HP:0000603)7.24790512
5Abolished electroretinogram (ERG) (HP:0000550)6.76735759
6Abnormality of macular pigmentation (HP:0008002)6.60739544
7Scotoma (HP:0000575)6.44917957
8Decreased central vision (HP:0007663)6.44142099
9Dyschromatopsia (HP:0007641)6.40379950
10Type II diabetes mellitus (HP:0005978)5.90375929
11Photophobia (HP:0000613)5.54451820
12Increased corneal curvature (HP:0100692)5.23412692
13Keratoconus (HP:0000563)5.23412692
14Macular degeneration (HP:0000608)5.21045494
15Intestinal atresia (HP:0011100)5.16982348
16Vitreoretinal degeneration (HP:0000655)5.15847494
17Cone-rod dystrophy (HP:0000548)4.48795301
18Posterior subcapsular cataract (HP:0007787)4.47628878
19Severe visual impairment (HP:0001141)4.47595702
20Retinitis pigmentosa (HP:0000510)4.39922497
21Depressed nasal tip (HP:0000437)4.35844614
22Abnormality of the phalanges of the 2nd finger (HP:0009541)4.16213858
23Choroideremia (HP:0001139)4.13038570
24Constricted visual fields (HP:0001133)3.85173103
25Decreased electroretinogram (ERG) amplitude (HP:0000654)3.59105287
26Esophageal atresia (HP:0002032)3.44157867
27High anterior hairline (HP:0009890)3.09762765
28Progressive visual loss (HP:0000529)3.06362393
29Growth hormone deficiency (HP:0000824)2.77882139
30Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.77542672
31Abnormality of chloride homeostasis (HP:0011422)2.76078770
32Wide nasal bridge (HP:0000431)2.65616811
33Optic nerve hypoplasia (HP:0000609)2.62593839
34Subcapsular cataract (HP:0000523)2.60801162
35Papillary thyroid carcinoma (HP:0002895)2.57623908
36Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.54807227
37Optic disc pallor (HP:0000543)2.51002389
38Gait imbalance (HP:0002141)2.50082565
39Congenital primary aphakia (HP:0007707)2.47081810
40Gastrointestinal atresia (HP:0002589)2.44941861
41Annular pancreas (HP:0001734)2.42427505
42Retinal atrophy (HP:0001105)2.39579161
43Supernumerary spleens (HP:0009799)2.37731597
44Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.33445575
45Short chin (HP:0000331)2.24669407
46Abnormality of the 2nd finger (HP:0004100)2.18721060
47Abnormality of the phalanges of the 5th finger (HP:0004213)2.17107843
48Nephrogenic diabetes insipidus (HP:0009806)2.16594128
49Oligodactyly (hands) (HP:0001180)2.14963005
502-3 toe syndactyly (HP:0004691)2.14871259
51Metabolic alkalosis (HP:0200114)2.12386292
52Medial flaring of the eyebrow (HP:0010747)2.09003043
53Protruding tongue (HP:0010808)2.08928560
54Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08816596
55Tubulointerstitial nephritis (HP:0001970)2.07794168
56Septate vagina (HP:0001153)2.01859476
57Congenital stationary night blindness (HP:0007642)16.6247704
58Absent rod-and cone-mediated responses on ERG (HP:0007688)11.3121442
59Bony spicule pigmentary retinopathy (HP:0007737)11.1641934
60Abnormal rod and cone electroretinograms (HP:0008323)10.7926723
61Pigmentary retinal degeneration (HP:0001146)10.1430142
62Polyphagia (HP:0002591)1.98959352
63Hypothermia (HP:0002045)1.97670010
64Type II lissencephaly (HP:0007260)1.92831360
65Hypoplastic labia majora (HP:0000059)1.91685075
66Mitral stenosis (HP:0001718)1.90212865
67Fair hair (HP:0002286)1.89638193
68Interstitial pulmonary disease (HP:0006530)1.87679239
69Congenital sensorineural hearing impairment (HP:0008527)1.87597131
70Labial hypoplasia (HP:0000066)1.87068974
71Abnormality of the renal medulla (HP:0100957)1.86976934
72Poor coordination (HP:0002370)1.86741227
73Widely spaced teeth (HP:0000687)1.85720931
74True hermaphroditism (HP:0010459)1.83719512
75Skull defect (HP:0001362)1.82809458
76Thyroid-stimulating hormone excess (HP:0002925)1.81339099
77Abnormality of the labia majora (HP:0012881)1.76700668
78Abnormal eating behavior (HP:0100738)1.75896077
79Retinal dysplasia (HP:0007973)1.73588306
80Vaginal atresia (HP:0000148)1.71465426
81Lissencephaly (HP:0001339)1.70723343
82Nephronophthisis (HP:0000090)1.68545201
83Oligodactyly (HP:0012165)1.68381412
84Optic atrophy (HP:0000648)1.68142175
85Abnormal pancreas size (HP:0012094)1.67420532
86Absent septum pellucidum (HP:0001331)1.67367007
87Hypoplastic female external genitalia (HP:0012815)1.67154837
88Male infertility (HP:0003251)1.65783238
89Preaxial hand polydactyly (HP:0001177)1.65140203
90Abnormality of the right ventricle (HP:0001707)1.64725835
91Abnormality of the renal cortex (HP:0011035)1.64601604
92Molar tooth sign on MRI (HP:0002419)1.64109023
93Abnormality of midbrain morphology (HP:0002418)1.64109023
94Abnormality of the labia (HP:0000058)1.63531582
95Genital tract atresia (HP:0001827)1.63271755
96Megalocornea (HP:0000485)1.62836686
97Thyroid carcinoma (HP:0002890)1.61732529
98Abnormality of the septum pellucidum (HP:0007375)1.60403939
99Limited hip movement (HP:0008800)1.58783108
100Focal seizures (HP:0007359)1.58579776
101Asplenia (HP:0001746)1.58226288
102Vertebral arch anomaly (HP:0008438)1.52683268
103Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.52535768
104Cubitus valgus (HP:0002967)1.51681487
105Hypokalemic alkalosis (HP:0001949)1.48547785
106Submucous cleft hard palate (HP:0000176)1.48515488
107Aplasia/Hypoplasia of the spleen (HP:0010451)1.48303417
108Spinal muscular atrophy (HP:0007269)1.47961246
109Aplasia/hypoplasia of the uterus (HP:0008684)1.47938530
110Polar cataract (HP:0010696)1.41332498
111Aplasia/Hypoplasia of the lens (HP:0008063)1.41267453
112Horizontal nystagmus (HP:0000666)1.18946242
113Severe Myopia (HP:0011003)1.18184770
114Recurrent sinusitis (HP:0011108)1.15303741
115Dysdiadochokinesis (HP:0002075)1.15102370
116Pancreatic fibrosis (HP:0100732)1.14807368
117Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.10253106
118Cerebellar dysplasia (HP:0007033)1.06518517
119Abnormality of the fovea (HP:0000493)1.05857838
120Broad foot (HP:0001769)1.04129418
121Left ventricular hypertrophy (HP:0001712)1.03908641
122Cystic liver disease (HP:0006706)1.03728201
123Specific learning disability (HP:0001328)1.02629871
124Hypoplasia of the fovea (HP:0007750)1.02612691
125Aplasia/Hypoplasia of the fovea (HP:0008060)1.02612691
126Decreased testicular size (HP:0008734)1.02301533
127Retinal detachment (HP:0000541)1.01881139
128Epileptic encephalopathy (HP:0200134)0.97182656
129Aplasia/Hypoplasia of the tongue (HP:0010295)0.94254807
130Sclerocornea (HP:0000647)0.94021327
131Astigmatism (HP:0000483)0.92383891
132Aplasia/Hypoplasia of the macula (HP:0008059)0.91767415
133Visual hallucinations (HP:0002367)0.91146071
134Abnormal gallbladder physiology (HP:0012438)0.89307313
135Cholecystitis (HP:0001082)0.89307313
136Pancreatic cysts (HP:0001737)0.88657611
137Asthma (HP:0002099)0.88168579
138Abnormal sex determination (HP:0012244)0.87681968
139Sex reversal (HP:0012245)0.87681968
140Aplasia/Hypoplasia affecting the retina (HP:0008061)0.84795360
141Septo-optic dysplasia (HP:0100842)0.82304768
142Truncal ataxia (HP:0002078)0.80505494
143Partial agenesis of the corpus callosum (HP:0001338)0.77722180
144Febrile seizures (HP:0002373)0.76069383
145Hypermetropia (HP:0000540)0.75985940
146Progressive cerebellar ataxia (HP:0002073)0.72352296
147Chorioretinal coloboma (HP:0000567)0.71973215
148Furrowed tongue (HP:0000221)0.70355391
149Dental crowding (HP:0000678)0.68711996
150Heterotopia (HP:0002282)0.67317328
151Abnormality of dental color (HP:0011073)0.67047239
152Hypodontia (HP:0000668)0.66728766
153Action tremor (HP:0002345)0.65783955
154Polycystic ovaries (HP:0000147)0.65368770
155Hypoventilation (HP:0002791)0.64296342
156Postaxial hand polydactyly (HP:0001162)0.60476881
157Short foot (HP:0001773)0.60476381
158Myokymia (HP:0002411)0.60253149
159Hypoglycemic seizures (HP:0002173)0.60061606
160Abnormality of abdominal situs (HP:0011620)0.59824787
161Abdominal situs inversus (HP:0003363)0.59824787
162Osteomalacia (HP:0002749)0.59078899
163Lymphopenia (HP:0001888)0.58990796
164Anencephaly (HP:0002323)0.57316769
165Aqueductal stenosis (HP:0002410)0.57099034
166Prolonged QT interval (HP:0001657)0.55890697

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK19.10417028
2PBK8.09281267
3LMTK26.66085801
4CCNB13.91179119
5IRAK22.84782578
6INSRR2.74578944
7STK392.27766958
8ICK2.25045255
9TLK12.22147418
10PINK12.19307140
11ADRBK22.04611809
12OXSR11.94188160
13BCR1.89575401
14MAP2K71.88701998
15MAP3K101.87476154
16MAPK131.85220338
17MAP4K21.85175098
18TGFBR11.82291762
19PASK1.80082516
20RPS6KA41.75421675
21NEK11.72120176
22BCKDK1.67793034
23ADRBK11.65693550
24MAPK71.64642290
25CSNK1G11.58661015
26TRIM281.52357109
27FRK1.51387377
28CAMK1G1.49896323
29TAOK31.47577263
30PRKCZ1.43023077
31CDK31.42915939
32SGK2231.38266618
33SGK4941.38266618
34NME11.36660325
35WNK31.30075193
36MARK11.25821715
37CAMK1D1.25718267
38SIK21.20973500
39ZAK1.20659260
40DAPK21.16401629
41NEK21.15439160
42PRKG21.14969653
43SCYL21.14878454
44BMPR1B1.14278548
45EPHA41.14083410
46PNCK1.05453354
47STK38L1.04346314
48HIPK20.97371663
49STK380.96636894
50PHKG10.94960545
51PHKG20.94960545
52PAK60.93793843
53OBSCN0.92855762
54PRKCE0.92414774
55PDGFRB0.89847786
56ERBB20.88887681
57CDK190.88378741
58CSNK1D0.88197053
59MAPK120.87104408
60PRKCH0.86607202
61CSNK1G20.86437003
62MKNK10.84558970
63PRKD30.84247619
64TNIK0.83040985
65CASK0.81907701
66RPS6KB20.78555548
67MAP3K140.78522106
68CDK120.77055441
69MAP3K40.73902011
70CAMKK10.72998106
71BRD40.72997388
72WNK40.71286567
73FER0.70131256
74PRKAA10.68883858
75EPHA30.68690608
76PRKCQ0.68467211
77GRK50.68099820
78ACVR1B0.68050314
79CSNK1A1L0.67537940
80DYRK20.64002413
81VRK10.60368906
82PRKCB0.60099466
83NEK60.59590725
84DYRK1A0.59372048
85RPS6KA50.59335767
86CSNK1G30.58763078
87WNK10.57622585
88DYRK1B0.57113767
89MAP3K60.53716204
90PKN10.52194881
91TSSK60.50771507
92ATM0.50462574
93MKNK20.49854620
94MYLK0.48211142
95STK110.47688893
96PRKCG0.47087416
97* CAMK2A0.46465670
98CAMK10.46344155
99PRKACB0.46336381
100SRPK10.46318215
101SGK10.45831263
102SGK20.45747975
103AKT20.45621685
104CAMK2D0.45471116
105PLK20.45252597
106PRKG10.44245729
107TTK0.44124500
108MAPK90.43952674
109SGK30.43651833
110PLK40.43620858
111GSK3A0.42489348
112CSNK1A10.41880706
113MAP2K10.41589075
114DYRK30.41580113
115PRKDC0.40658721
116NTRK30.38082074
117ERBB30.37962902
118PLK30.37412945
119* RPS6KA30.37164211
120CHEK20.37130682
121PRKAA20.36728324
122* PRKACG0.36399096
123FES0.35637191
124MUSK0.34992044
125STK30.34700870
126GSK3B0.34575915
127MAPK140.33443022
128SIK10.33293222
129MINK10.32914779
130FGFR10.32419140
131CDK50.31937268
132LATS10.31738599
133PIK3CA0.31096692
134AURKA0.31087518
135PRKD20.30979458
136PRKCA0.30571231
137MAPK100.29118179
138AKT30.29053405
139RPS6KB10.28756638
140NTRK20.27029773
141PRKCI0.26994413
142ALK0.25808454
143CAMK40.25587415
144CSNK1E0.25045995
145CDC42BPA0.23430744
146CDK10.22987574
147MAP3K70.20884785
148* PRKACA0.19769366
149CDK150.19758079
150CDK90.17203622
151PAK30.17007045
152CDK180.16803721
153FYN0.16716278
154SRC0.15446092
155MAP2K40.14591282
156CDK11A0.13833903
157MAPK30.13593014

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.78103234
2Phototransduction_Homo sapiens_hsa0474415.8717900
3Synaptic vesicle cycle_Homo sapiens_hsa047211.74303341
4beta-Alanine metabolism_Homo sapiens_hsa004101.66916120
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58222997
6Long-term depression_Homo sapiens_hsa047301.57380598
7Olfactory transduction_Homo sapiens_hsa047401.51874298
8Ether lipid metabolism_Homo sapiens_hsa005651.43838199
9Protein export_Homo sapiens_hsa030601.43424176
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39460640
11Phenylalanine metabolism_Homo sapiens_hsa003601.27035416
12GABAergic synapse_Homo sapiens_hsa047271.21612485
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19874386
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17855096
15Butanoate metabolism_Homo sapiens_hsa006501.15579902
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11922681
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07977649
18Retinol metabolism_Homo sapiens_hsa008301.01916950
19Axon guidance_Homo sapiens_hsa043601.01279928
20Propanoate metabolism_Homo sapiens_hsa006400.99669681
21Linoleic acid metabolism_Homo sapiens_hsa005910.96683696
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96409840
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92714370
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91045142
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90027368
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87161978
27Hedgehog signaling pathway_Homo sapiens_hsa043400.86380484
28Cholinergic synapse_Homo sapiens_hsa047250.85781373
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81557123
30Dopaminergic synapse_Homo sapiens_hsa047280.81372557
31Nitrogen metabolism_Homo sapiens_hsa009100.80665201
32Vibrio cholerae infection_Homo sapiens_hsa051100.79945424
33Circadian entrainment_Homo sapiens_hsa047130.78647968
34Morphine addiction_Homo sapiens_hsa050320.77968345
35Systemic lupus erythematosus_Homo sapiens_hsa053220.77712051
36Steroid hormone biosynthesis_Homo sapiens_hsa001400.76517041
37Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74229007
38Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73800151
39Glutamatergic synapse_Homo sapiens_hsa047240.73790328
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65791654
41Histidine metabolism_Homo sapiens_hsa003400.65248044
42RNA degradation_Homo sapiens_hsa030180.63089630
43Arginine biosynthesis_Homo sapiens_hsa002200.62873430
44Circadian rhythm_Homo sapiens_hsa047100.62794380
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62154633
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59537781
47Basal cell carcinoma_Homo sapiens_hsa052170.59083086
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57530981
49Tryptophan metabolism_Homo sapiens_hsa003800.55985893
50Serotonergic synapse_Homo sapiens_hsa047260.55656194
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53879291
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53483178
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52301228
54Chemical carcinogenesis_Homo sapiens_hsa052040.51851167
55Insulin secretion_Homo sapiens_hsa049110.50925517
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50396491
57Tyrosine metabolism_Homo sapiens_hsa003500.49578490
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49122148
59Dorso-ventral axis formation_Homo sapiens_hsa043200.48902538
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48576917
61ABC transporters_Homo sapiens_hsa020100.47572939
62Alzheimers disease_Homo sapiens_hsa050100.47104179
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46500422
64mTOR signaling pathway_Homo sapiens_hsa041500.46319376
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45753220
66Nicotine addiction_Homo sapiens_hsa050330.45295322
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45243772
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44434110
69Oxidative phosphorylation_Homo sapiens_hsa001900.44432000
70Fructose and mannose metabolism_Homo sapiens_hsa000510.43313359
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43259060
72Biosynthesis of amino acids_Homo sapiens_hsa012300.42920764
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36786407
74Hippo signaling pathway_Homo sapiens_hsa043900.36008597
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35584880
76cAMP signaling pathway_Homo sapiens_hsa040240.34324725
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33857233
78Oxytocin signaling pathway_Homo sapiens_hsa049210.33632705
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.33299841
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32642450
81Sulfur metabolism_Homo sapiens_hsa009200.32496067
82Dilated cardiomyopathy_Homo sapiens_hsa054140.32245002
83Inositol phosphate metabolism_Homo sapiens_hsa005620.32160408
84Estrogen signaling pathway_Homo sapiens_hsa049150.31427465
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30790261
86Type II diabetes mellitus_Homo sapiens_hsa049300.30316097
87Galactose metabolism_Homo sapiens_hsa000520.29204918
88Cardiac muscle contraction_Homo sapiens_hsa042600.28539593
89Purine metabolism_Homo sapiens_hsa002300.28454830
90Renin secretion_Homo sapiens_hsa049240.26832437
91Salivary secretion_Homo sapiens_hsa049700.26532219
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25944279
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25870743
94HIF-1 signaling pathway_Homo sapiens_hsa040660.24397085
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24365105
96Alcoholism_Homo sapiens_hsa050340.23432253
97Glucagon signaling pathway_Homo sapiens_hsa049220.22867711
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.22654067
99Gastric acid secretion_Homo sapiens_hsa049710.21882050
100AMPK signaling pathway_Homo sapiens_hsa041520.20645818
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20095458
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.19954258
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.19581334
104Fatty acid elongation_Homo sapiens_hsa000620.18932122
105Bile secretion_Homo sapiens_hsa049760.18481311
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.18349018
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18264197
108Cocaine addiction_Homo sapiens_hsa050300.18081065
109Vitamin B6 metabolism_Homo sapiens_hsa007500.17467903
110Long-term potentiation_Homo sapiens_hsa047200.17238315
111Glycerolipid metabolism_Homo sapiens_hsa005610.16523265
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16048046
113Chemokine signaling pathway_Homo sapiens_hsa040620.15927025
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15923260
115Caffeine metabolism_Homo sapiens_hsa002320.14808036
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.14716835
117Amphetamine addiction_Homo sapiens_hsa050310.13138653
118Pyruvate metabolism_Homo sapiens_hsa006200.13007970
119Lysine degradation_Homo sapiens_hsa003100.12173151
120mRNA surveillance pathway_Homo sapiens_hsa030150.11776215
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.11327347
122Taste transduction_Homo sapiens_hsa047420.11136666
123Vitamin digestion and absorption_Homo sapiens_hsa049770.10909523
124Carbon metabolism_Homo sapiens_hsa012000.10733288
125Collecting duct acid secretion_Homo sapiens_hsa049660.10622339
126Tight junction_Homo sapiens_hsa045300.10306365
127Calcium signaling pathway_Homo sapiens_hsa040200.09881100
128Insulin resistance_Homo sapiens_hsa049310.09503664
129Ras signaling pathway_Homo sapiens_hsa040140.08010473
130Pancreatic secretion_Homo sapiens_hsa049720.07211606
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.06074680
132GnRH signaling pathway_Homo sapiens_hsa049120.06055321
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.05769365
134Thyroid hormone synthesis_Homo sapiens_hsa049180.05460922
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.04899107
136Fat digestion and absorption_Homo sapiens_hsa049750.04158669
137Notch signaling pathway_Homo sapiens_hsa043300.03331827
138Starch and sucrose metabolism_Homo sapiens_hsa005000.03276939
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.03118200
140Gap junction_Homo sapiens_hsa045400.03063277
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.02810844
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.02062346
143Choline metabolism in cancer_Homo sapiens_hsa052310.01980572
144Ovarian steroidogenesis_Homo sapiens_hsa049130.01499651
145Melanogenesis_Homo sapiens_hsa049160.01463012

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