PDCD10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.59420922
2central nervous system myelination (GO:0022010)4.66703988
3axon ensheathment in central nervous system (GO:0032291)4.66703988
4neutrophil activation involved in immune response (GO:0002283)4.66244379
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.46792872
6CENP-A containing nucleosome assembly (GO:0034080)4.33087096
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.32980424
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.27396727
9ATP synthesis coupled proton transport (GO:0015986)4.27396727
10rRNA modification (GO:0000154)4.24982914
11regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.17973851
12chromatin remodeling at centromere (GO:0031055)4.11350606
13rRNA methylation (GO:0031167)4.05937716
14long-chain fatty acid biosynthetic process (GO:0042759)3.97912763
15anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.87713688
16ribosome assembly (GO:0042255)3.82135524
17fatty acid elongation (GO:0030497)3.79608159
18purine nucleobase biosynthetic process (GO:0009113)3.72117391
19establishment of integrated proviral latency (GO:0075713)3.66759228
20DNA double-strand break processing (GO:0000729)3.66320126
21exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.63069238
22respiratory electron transport chain (GO:0022904)3.62514946
23positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.58633999
24histone exchange (GO:0043486)3.57144139
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.55471518
26positive regulation of monocyte chemotaxis (GO:0090026)3.53719974
27electron transport chain (GO:0022900)3.52746259
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.49151724
29NADH dehydrogenase complex assembly (GO:0010257)3.49151724
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49151724
31positive regulation of ligase activity (GO:0051351)3.48227357
32mitotic metaphase plate congression (GO:0007080)3.42748019
33DNA catabolic process, exonucleolytic (GO:0000738)3.39850454
34DNA deamination (GO:0045006)3.38523709
35protein complex biogenesis (GO:0070271)3.37685457
36regulation of metalloenzyme activity (GO:0048552)3.34547745
37regulation of ubiquitin-protein transferase activity (GO:0051438)3.24304502
38histone mRNA metabolic process (GO:0008334)3.22215636
39maturation of 5.8S rRNA (GO:0000460)3.21670183
40chaperone-mediated protein transport (GO:0072321)3.21310987
41metaphase plate congression (GO:0051310)3.20422553
42DNA replication checkpoint (GO:0000076)3.19021250
43regulation of ligase activity (GO:0051340)3.17058175
44somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.16062962
45isotype switching (GO:0045190)3.16062962
46somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.16062962
47DNA replication-independent nucleosome assembly (GO:0006336)3.15736330
48DNA replication-independent nucleosome organization (GO:0034724)3.15736330
49nucleobase biosynthetic process (GO:0046112)3.15363099
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.07083988
51proteasome assembly (GO:0043248)3.06179660
52regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04946531
53regulation of mitotic spindle checkpoint (GO:1903504)3.04946531
54antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.04629598
55pseudouridine synthesis (GO:0001522)3.02441597
56phagosome maturation (GO:0090382)3.02126225
57protein K6-linked ubiquitination (GO:0085020)3.01918020
58signal peptide processing (GO:0006465)3.00785659
59telomere maintenance via semi-conservative replication (GO:0032201)3.00236018
60regulation of activation of Janus kinase activity (GO:0010533)2.98963775
61purine-containing compound salvage (GO:0043101)2.98474049
62neutrophil activation (GO:0042119)2.96521632
63lactate metabolic process (GO:0006089)2.95880335
64G1/S transition of mitotic cell cycle (GO:0000082)2.90023797
65cell cycle G1/S phase transition (GO:0044843)2.90023797
66IMP biosynthetic process (GO:0006188)2.89839739
67mitotic G2/M transition checkpoint (GO:0044818)2.89354064
68regulation of centriole replication (GO:0046599)2.89240148
69regulation of memory T cell differentiation (GO:0043380)2.88772037
70mannosylation (GO:0097502)2.88734882
71DNA strand elongation involved in DNA replication (GO:0006271)2.86479771
72mitochondrial respiratory chain complex assembly (GO:0033108)2.86315828
73GPI anchor biosynthetic process (GO:0006506)2.86257402
74negative regulation of protein ubiquitination (GO:0031397)2.84458313
75platelet dense granule organization (GO:0060155)2.83898980
76protein targeting to mitochondrion (GO:0006626)2.83759275
77transcription elongation from RNA polymerase III promoter (GO:0006385)2.83185302
78termination of RNA polymerase III transcription (GO:0006386)2.83185302
79regulation of cellular amine metabolic process (GO:0033238)2.81989230
80DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.81373126
81respiratory burst (GO:0045730)2.80968677
82DNA ligation (GO:0006266)2.80720346
83pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.80287194
84protein K11-linked ubiquitination (GO:0070979)2.79061545
85granulocyte activation (GO:0036230)2.77946925
86isoprenoid biosynthetic process (GO:0008299)2.77158543
87preassembly of GPI anchor in ER membrane (GO:0016254)2.75422633
88kinetochore organization (GO:0051383)2.74660847
89positive regulation of interleukin-17 production (GO:0032740)2.74582553
90regulation of cellular amino acid metabolic process (GO:0006521)2.74533652
91negative regulation of DNA-dependent DNA replication (GO:2000104)2.74135883
92establishment of chromosome localization (GO:0051303)2.71489790
93cholesterol biosynthetic process (GO:0006695)2.71256664
94protein localization to mitochondrion (GO:0070585)2.71174524
95pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.70831402
96cullin deneddylation (GO:0010388)2.70720989
97DNA strand elongation (GO:0022616)2.70687608
98RNA capping (GO:0036260)2.70549993
997-methylguanosine RNA capping (GO:0009452)2.70549993
100telomere maintenance via recombination (GO:0000722)2.70227367
101establishment of protein localization to mitochondrial membrane (GO:0090151)2.70170055
102negative regulation of neurotransmitter transport (GO:0051589)2.68861584
103negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.68485424
104mitotic G2 DNA damage checkpoint (GO:0007095)2.67294141
105positive regulation of cell cycle arrest (GO:0071158)2.67011504
106protein localization to kinetochore (GO:0034501)2.66815406
1077-methylguanosine mRNA capping (GO:0006370)2.66812402
108positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.66648262
109transcription elongation from RNA polymerase I promoter (GO:0006362)2.66299360
110eosinophil chemotaxis (GO:0048245)2.65026890
111negative regulation of neurotransmitter secretion (GO:0046929)2.64482252
112positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.63745652
113regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.61767216
114ribosomal small subunit biogenesis (GO:0042274)2.60161032
115DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.59469444
116positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.57724258
117leukocyte degranulation (GO:0043299)2.55435532
118antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.55019099
119substantia nigra development (GO:0021762)2.54601737
120L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.54114134
121intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.51902096
122signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.51902096
123negative regulation of ligase activity (GO:0051352)2.49662736
124negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49662736
125autophagic vacuole fusion (GO:0000046)2.49210914
126energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.48155536
127ATP hydrolysis coupled proton transport (GO:0015991)2.48155536
128superoxide anion generation (GO:0042554)2.47526254
129signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.47427770
130signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.47427770
131signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.47427770
132GPI anchor metabolic process (GO:0006505)2.45999706
133hydrogen ion transmembrane transport (GO:1902600)2.45212196
134sterol biosynthetic process (GO:0016126)2.45037503
135cellular response to interferon-beta (GO:0035458)2.44666983
136positive regulation of alpha-beta T cell proliferation (GO:0046641)2.43704227
137cytochrome complex assembly (GO:0017004)2.42814684
138regulation of interleukin-17 production (GO:0032660)2.42381331
139establishment of viral latency (GO:0019043)2.42194252
140mast cell activation (GO:0045576)2.42166964
141respiratory chain complex IV assembly (GO:0008535)2.41699312
142proton transport (GO:0015992)2.41174451
143amyloid precursor protein metabolic process (GO:0042982)2.39783737
144positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.38718078
145GTP biosynthetic process (GO:0006183)2.38121741
146positive regulation of T-helper 1 type immune response (GO:0002827)2.37135011
147regulation of monocyte chemotaxis (GO:0090025)2.36300843
148eosinophil migration (GO:0072677)2.35368870
149protein deneddylation (GO:0000338)2.35335615
150intracellular pH reduction (GO:0051452)2.34420873
151Rap protein signal transduction (GO:0032486)2.33961894
152hydrogen transport (GO:0006818)2.32904796
153signal transduction involved in DNA integrity checkpoint (GO:0072401)2.32182258
154signal transduction involved in DNA damage checkpoint (GO:0072422)2.32182258
155regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.32173012
156signal transduction involved in cell cycle checkpoint (GO:0072395)2.30033415
157response to redox state (GO:0051775)2.28038158
158presynaptic membrane assembly (GO:0097105)2.27959595
159sequestering of actin monomers (GO:0042989)2.27436088
160transferrin transport (GO:0033572)2.27173308
161regulation of T cell migration (GO:2000404)2.26390799
162cotranslational protein targeting to membrane (GO:0006613)2.24495513

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.32006063
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.08434163
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.51610121
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.50748615
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46210388
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.37778856
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.23012891
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.09970960
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.91538034
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.90034474
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.81959599
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.67609305
13TAF15_26573619_Chip-Seq_HEK293_Human2.51297136
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42712582
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.42472330
16ELK1_19687146_ChIP-ChIP_HELA_Human2.38158994
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36592736
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32700670
19VDR_22108803_ChIP-Seq_LS180_Human2.30294644
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25316074
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25041246
22FOXP3_21729870_ChIP-Seq_TREG_Human2.20977681
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20684993
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18350337
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17456307
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13942608
27* PADI4_21655091_ChIP-ChIP_MCF-7_Human2.10544703
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03389367
29CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03105394
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.99915217
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98055262
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95241150
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.92619984
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.92554161
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88601780
36FUS_26573619_Chip-Seq_HEK293_Human1.81951756
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81384557
38GBX2_23144817_ChIP-Seq_PC3_Human1.81048112
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76804215
40ER_23166858_ChIP-Seq_MCF-7_Human1.74544285
41* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73567927
42* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68229972
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66174309
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66055361
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61266838
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61043074
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60937954
48VDR_23849224_ChIP-Seq_CD4+_Human1.59948243
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.58229616
50AR_21909140_ChIP-Seq_LNCAP_Human1.58178389
51P300_19829295_ChIP-Seq_ESCs_Human1.55712550
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.54878434
53* ETS1_20019798_ChIP-Seq_JURKAT_Human1.53497322
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52151522
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51167176
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47590739
57EWS_26573619_Chip-Seq_HEK293_Human1.47208769
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44935604
59* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43377175
60IRF1_19129219_ChIP-ChIP_H3396_Human1.42542792
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40266494
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.40047059
63* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39696284
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36427105
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35588633
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.35239667
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.34401781
68MYC_18940864_ChIP-ChIP_HL60_Human1.34355262
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.34040372
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34025113
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31000582
72IGF1R_20145208_ChIP-Seq_DFB_Human1.30985754
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.28696553
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28696536
75GATA1_22025678_ChIP-Seq_K562_Human1.27944722
76* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27806419
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27637118
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.27477142
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26785469
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26765205
81GABP_19822575_ChIP-Seq_HepG2_Human1.26729983
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26243684
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.25051438
84* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24585625
85TTF2_22483619_ChIP-Seq_HELA_Human1.24373813
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.23196184
87P53_22387025_ChIP-Seq_ESCs_Mouse1.23003000
88EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.20514142
89DCP1A_22483619_ChIP-Seq_HELA_Human1.19982038
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19687271
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18793936
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17400378
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17400378
94P300_18555785_Chip-Seq_ESCs_Mouse1.16966998
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.16675264
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15968377
97* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14420987
98NOTCH1_21737748_ChIP-Seq_TLL_Human1.13612508
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.13056715
100* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12539053
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12433014
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11659553
103NMYC_18555785_Chip-Seq_ESCs_Mouse1.11531852
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.11378492
105SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10946374
106ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09602744
107RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09037912
108STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08538860
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.08235222
110SALL4_22934838_ChIP-ChIP_CD34+_Human1.08135586
111SOX2_18555785_Chip-Seq_ESCs_Mouse1.07873083
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07782245
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06370951
114CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06024300
115JUN_21703547_ChIP-Seq_K562_Human1.05597326
116SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05477260
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04506806
118SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03941141
119ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03676704
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03023819
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02933022
122POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01548800
123NFE2_27457419_Chip-Seq_LIVER_Mouse0.99961784
124TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99878680
125TFEB_21752829_ChIP-Seq_HELA_Human0.99847341
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99158206
127FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96986719
128NANOG_19829295_ChIP-Seq_ESCs_Human0.96253082
129SOX2_19829295_ChIP-Seq_ESCs_Human0.96253082
130* SPI1_23547873_ChIP-Seq_NB4_Human0.96231102
131NANOG_16153702_ChIP-ChIP_HESCs_Human0.95056972
132KLF4_18555785_Chip-Seq_ESCs_Mouse0.93672425
133PIAS1_25552417_ChIP-Seq_VCAP_Human0.93383794
134ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92783447
135HTT_18923047_ChIP-ChIP_STHdh_Human0.92584033
136TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92402500
137OCT4_18555785_Chip-Seq_ESCs_Mouse0.92286689
138CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91297526
139ELF5_23300383_ChIP-Seq_T47D_Human0.91277088
140CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91268076
141SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90557845
142POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89158436
143EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86369629
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85763237
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84721997
146XRN2_22483619_ChIP-Seq_HELA_Human0.83343548
147KDM5A_27292631_Chip-Seq_BREAST_Human0.82165782
148ZNF274_21170338_ChIP-Seq_K562_Hela0.80258388
149CRX_20693478_ChIP-Seq_RETINA_Mouse0.79559483
150* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79012542
151FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78800642

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog3.81091202
2MP0008058_abnormal_DNA_repair3.65598873
3MP0010094_abnormal_chromosome_stability3.52467912
4MP0003880_abnormal_central_pattern3.33565163
5MP0003806_abnormal_nucleotide_metabolis3.31863392
6MP0003693_abnormal_embryo_hatching3.21974092
7MP0002148_abnormal_hypersensitivity_rea3.06234814
8MP0009785_altered_susceptibility_to2.99385310
9MP0005464_abnormal_platelet_physiology2.97773518
10MP0001835_abnormal_antigen_presentation2.88379073
11MP0001529_abnormal_vocalization2.69809024
12MP0005671_abnormal_response_to2.62841015
13MP0000920_abnormal_myelination2.59799309
14MP0008877_abnormal_DNA_methylation2.59355378
15MP0003950_abnormal_plasma_membrane2.53674582
16MP0001986_abnormal_taste_sensitivity2.49879615
17MP0003111_abnormal_nucleus_morphology2.49257459
18MP0003077_abnormal_cell_cycle2.42218983
19MP0006036_abnormal_mitochondrial_physio2.40663238
20MP0003724_increased_susceptibility_to2.37566331
21MP0005000_abnormal_immune_tolerance2.32904154
22MP0001905_abnormal_dopamine_level2.32723181
23MP0005171_absent_coat_pigmentation2.26458864
24MP0008932_abnormal_embryonic_tissue2.26298307
25MP0006082_CNS_inflammation2.18510167
26MP0001790_abnormal_immune_system2.14285046
27MP0005387_immune_system_phenotype2.14285046
28MP0002163_abnormal_gland_morphology2.10937529
29MP0003786_premature_aging2.07870515
30MP0003941_abnormal_skin_development2.05910221
31MP0006035_abnormal_mitochondrial_morpho2.01930639
32MP0003136_yellow_coat_color2.00310238
33MP0005025_abnormal_response_to1.98581275
34MP0008007_abnormal_cellular_replicative1.96205933
35MP0005084_abnormal_gallbladder_morpholo1.94957193
36MP0002419_abnormal_innate_immunity1.89643295
37MP0009379_abnormal_foot_pigmentation1.87026640
38MP0000372_irregular_coat_pigmentation1.86223128
39MP0002723_abnormal_immune_serum1.83924060
40MP0006054_spinal_hemorrhage1.75033408
41MP0002452_abnormal_antigen_presenting1.73077761
42MP0001800_abnormal_humoral_immune1.71167183
43MP0002009_preneoplasia1.68329928
44MP0001819_abnormal_immune_cell1.65963293
45MP0002420_abnormal_adaptive_immunity1.65837618
46MP0002277_abnormal_respiratory_mucosa1.63662600
47MP0003436_decreased_susceptibility_to1.63405233
48MP0004381_abnormal_hair_follicle1.61459476
49MP0004742_abnormal_vestibular_system1.58369267
50MP0008004_abnormal_stomach_pH1.55409080
51MP0008057_abnormal_DNA_replication1.54248476
52MP0005310_abnormal_salivary_gland1.53137798
53MP0003890_abnormal_embryonic-extraembry1.50297191
54MP0009333_abnormal_splenocyte_physiolog1.48302644
55MP0005379_endocrine/exocrine_gland_phen1.47246750
56MP0002876_abnormal_thyroid_physiology1.46914731
57MP0001188_hyperpigmentation1.46887885
58MP0005408_hypopigmentation1.46729534
59MP0001853_heart_inflammation1.44596018
60MP0000685_abnormal_immune_system1.44129488
61MP0004142_abnormal_muscle_tone1.43527100
62MP0002102_abnormal_ear_morphology1.42616696
63MP0000358_abnormal_cell_content/1.42227985
64MP0002736_abnormal_nociception_after1.41437729
65MP0002735_abnormal_chemical_nociception1.40328728
66MP0001542_abnormal_bone_strength1.39685540
67MP0003656_abnormal_erythrocyte_physiolo1.38128795
68MP0010386_abnormal_urinary_bladder1.37850958
69MP0004147_increased_porphyrin_level1.37110250
70MP0008260_abnormal_autophagy1.33896950
71MP0006276_abnormal_autonomic_nervous1.31594278
72MP0001968_abnormal_touch/_nociception1.27142052
73MP0005409_darkened_coat_color1.26101190
74MP0001730_embryonic_growth_arrest1.25874738
75MP0008872_abnormal_physiological_respon1.24350621
76MP0003186_abnormal_redox_activity1.24284537
77MP0003195_calcinosis1.23485029
78MP0010234_abnormal_vibrissa_follicle1.23222411
79MP0001697_abnormal_embryo_size1.19225225
80MP0006072_abnormal_retinal_apoptosis1.18077012
81MP0002272_abnormal_nervous_system1.17809716
82MP0000015_abnormal_ear_pigmentation1.16638169
83MP0002405_respiratory_system_inflammati1.16062524
84MP0009697_abnormal_copulation1.15500657
85MP0003718_maternal_effect1.13686726
86MP0001533_abnormal_skeleton_physiology1.13057539
87MP0002734_abnormal_mechanical_nocicepti1.13011112
88MP0004215_abnormal_myocardial_fiber1.12447631
89MP0010307_abnormal_tumor_latency1.11015830
90MP0010352_gastrointestinal_tract_polyps1.10409532
91MP0000716_abnormal_immune_system1.09885853
92MP0000350_abnormal_cell_proliferation1.09518533
93MP0002006_tumorigenesis1.09466643
94MP0002019_abnormal_tumor_incidence1.07653205
95MP0002064_seizures1.05029718
96MP0000313_abnormal_cell_death1.03300440
97MP0001970_abnormal_pain_threshold1.03123652
98MP0002638_abnormal_pupillary_reflex1.01983804
99MP0001845_abnormal_inflammatory_respons1.01590592
100MP0005636_abnormal_mineral_homeostasis1.00540396
101MP0003763_abnormal_thymus_physiology0.99657901
102MP0005164_abnormal_response_to0.99257975
103MP0001727_abnormal_embryo_implantation0.96924344
104MP0003690_abnormal_glial_cell0.96704386
105MP0004270_analgesia0.95711101
106MP0002933_joint_inflammation0.94921075
107MP0005058_abnormal_lysosome_morphology0.94883626
108MP0002837_dystrophic_cardiac_calcinosis0.94281074
109MP0001440_abnormal_grooming_behavior0.93694412
110MP0009046_muscle_twitch0.93582924
111MP0002398_abnormal_bone_marrow0.93474229
112MP0001919_abnormal_reproductive_system0.93273713
113MP0004782_abnormal_surfactant_physiolog0.92534226
114MP0005451_abnormal_body_composition0.92355853
115MP0001929_abnormal_gametogenesis0.92212757
116MP0005410_abnormal_fertilization0.91388209
117MP0005075_abnormal_melanosome_morpholog0.90855444
118MP0000647_abnormal_sebaceous_gland0.89928897
119MP0002210_abnormal_sex_determination0.87970899
120MP0005501_abnormal_skin_physiology0.87881304
121MP0004510_myositis0.87814648
122MP0008995_early_reproductive_senescence0.85344164
123MP0003866_abnormal_defecation0.85146647
124MP0005083_abnormal_biliary_tract0.85068039
125MP0002396_abnormal_hematopoietic_system0.84426675
126MP0005389_reproductive_system_phenotype0.84360257
127MP0003567_abnormal_fetal_cardiomyocyte0.83873831
128MP0000490_abnormal_crypts_of0.83693048
129MP0010678_abnormal_skin_adnexa0.82492201
130MP0001346_abnormal_lacrimal_gland0.82490993
131MP0008775_abnormal_heart_ventricle0.82408727
132MP0000343_altered_response_to0.81987969
133MP0002722_abnormal_immune_system0.81658839
134MP0000681_abnormal_thyroid_gland0.81305321
135MP0010155_abnormal_intestine_physiology0.80849590
136MP0001486_abnormal_startle_reflex0.80844303
137MP0000465_gastrointestinal_hemorrhage0.80621796
138MP0002429_abnormal_blood_cell0.80409860
139MP0001851_eye_inflammation0.80299079
140MP0002080_prenatal_lethality0.79330500
141MP0008469_abnormal_protein_level0.79094667
142MP0009745_abnormal_behavioral_response0.78925233
143MP0001485_abnormal_pinna_reflex0.78284009
144MP0000653_abnormal_sex_gland0.77961841
145MP0005395_other_phenotype0.76767430
146MP0001881_abnormal_mammary_gland0.76469382
147MP0000604_amyloidosis0.75800343
148MP0004134_abnormal_chest_morphology0.75501409
149MP0001764_abnormal_homeostasis0.75454539
150MP0002166_altered_tumor_susceptibility0.75435654
151MP0003448_altered_tumor_morphology0.74541750
152MP0001963_abnormal_hearing_physiology0.74234985
153MP0000689_abnormal_spleen_morphology0.73709160
154MP0008873_increased_physiological_sensi0.73505124
155MP0008875_abnormal_xenobiotic_pharmacok0.72974663
156MP0001672_abnormal_embryogenesis/_devel0.72818605
157MP0005380_embryogenesis_phenotype0.72818605
158MP0001145_abnormal_male_reproductive0.72633175
159MP0003011_delayed_dark_adaptation0.72586028
160MP0002132_abnormal_respiratory_system0.71580446
161MP0003634_abnormal_glial_cell0.71426647
162MP0003183_abnormal_peptide_metabolism0.71353957
163MP0002938_white_spotting0.69926949
164MP0009763_increased_sensitivity_to0.69524159
165MP0002095_abnormal_skin_pigmentation0.69416568
166MP0001119_abnormal_female_reproductive0.69400980
167MP0002796_impaired_skin_barrier0.69227291
168MP0005174_abnormal_tail_pigmentation0.68755440
169MP0000427_abnormal_hair_cycle0.68410839

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.15403391
2Parakeratosis (HP:0001036)4.75786503
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.43616889
4Progressive macrocephaly (HP:0004481)4.41337263
5Abnormal mitochondria in muscle tissue (HP:0008316)4.38220606
6Mitochondrial inheritance (HP:0001427)4.29897780
7Acute encephalopathy (HP:0006846)3.84029036
8Increased CSF lactate (HP:0002490)3.40321937
9Hepatocellular necrosis (HP:0001404)3.34845444
10Abnormality of glycolysis (HP:0004366)3.28735961
11Increased serum pyruvate (HP:0003542)3.28735961
12Recurrent abscess formation (HP:0002722)3.28665883
13Increased hepatocellular lipid droplets (HP:0006565)3.27482805
14Renal Fanconi syndrome (HP:0001994)3.24477371
15Congenital ichthyosiform erythroderma (HP:0007431)3.19732029
163-Methylglutaconic aciduria (HP:0003535)3.17750599
17Abnormality of methionine metabolism (HP:0010901)3.17224623
18Leukodystrophy (HP:0002415)3.12949979
19Irregular epiphyses (HP:0010582)3.01985664
20Aplastic anemia (HP:0001915)2.94322473
21Recurrent bacterial skin infections (HP:0005406)2.90186806
22Oral leukoplakia (HP:0002745)2.86650250
23Abnormal hair whorl (HP:0010721)2.82734680
24Increased IgM level (HP:0003496)2.80044507
25Sensory axonal neuropathy (HP:0003390)2.76783801
26Optic disc pallor (HP:0000543)2.71834606
27Hepatic necrosis (HP:0002605)2.70293185
28Lipid accumulation in hepatocytes (HP:0006561)2.69462960
29Prolonged bleeding time (HP:0003010)2.67712549
30Abnormality of chromosome stability (HP:0003220)2.66861084
31Abnormality of aspartate family amino acid metabolism (HP:0010899)2.64809074
32Exertional dyspnea (HP:0002875)2.63981365
33Methylmalonic acidemia (HP:0002912)2.62660860
34Increased mean platelet volume (HP:0011877)2.59563427
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58874697
36Hepatosplenomegaly (HP:0001433)2.55669916
37Degeneration of anterior horn cells (HP:0002398)2.53215083
38Abnormality of the anterior horn cell (HP:0006802)2.53215083
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52260034
40Hypothermia (HP:0002045)2.51094534
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49550980
42Vacuolated lymphocytes (HP:0001922)2.48663715
43Respiratory failure (HP:0002878)2.44181135
44Abnormality of macrophages (HP:0004311)2.43941678
45Cerebral hypomyelination (HP:0006808)2.42554440
46Chromsome breakage (HP:0040012)2.42277515
47Hypoglycemic coma (HP:0001325)2.40580205
48Dyschromatopsia (HP:0007641)2.39587207
49Chronic obstructive pulmonary disease (HP:0006510)2.38276170
50Obstructive lung disease (HP:0006536)2.38276170
51Neuroendocrine neoplasm (HP:0100634)2.32147330
52Stomatitis (HP:0010280)2.31674253
53Abnormality of the heme biosynthetic pathway (HP:0010472)2.30956011
54Abnormality of the preputium (HP:0100587)2.29958775
55Abnormal platelet volume (HP:0011876)2.29938543
56Autoamputation (HP:0001218)2.29259315
57Acanthocytosis (HP:0001927)2.25299755
58Eczematoid dermatitis (HP:0000976)2.25102675
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23413610
60Patchy hypopigmentation of hair (HP:0011365)2.22966517
61Cerebral edema (HP:0002181)2.22260866
62Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.21909581
63Degeneration of the lateral corticospinal tracts (HP:0002314)2.21909581
64Methylmalonic aciduria (HP:0012120)2.20773936
65Nausea (HP:0002018)2.19894763
66Abnormality of renal resorption (HP:0011038)2.18199735
67Lethargy (HP:0001254)2.17247984
68Elevated erythrocyte sedimentation rate (HP:0003565)2.15282674
69Abnormality of T cell number (HP:0011839)2.14901403
70Exercise intolerance (HP:0003546)2.14794649
71Pancytopenia (HP:0001876)2.14461873
72Abnormality of alanine metabolism (HP:0010916)2.13501403
73Hyperalaninemia (HP:0003348)2.13501403
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13501403
75Xerostomia (HP:0000217)2.11683525
76Meckel diverticulum (HP:0002245)2.11437971
77Pancreatic islet-cell hyperplasia (HP:0004510)2.11356645
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.11175325
79Generalized aminoaciduria (HP:0002909)2.10311209
80Severe combined immunodeficiency (HP:0004430)2.09720412
81Medial flaring of the eyebrow (HP:0010747)2.09608556
82Recurrent skin infections (HP:0001581)2.09511958
83Abnormality of cells of the erythroid lineage (HP:0012130)2.09426970
84Poikilocytosis (HP:0004447)2.09393686
85Abnormal protein glycosylation (HP:0012346)2.07399023
86Abnormal glycosylation (HP:0012345)2.07399023
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.07399023
88Abnormal protein N-linked glycosylation (HP:0012347)2.07399023
89Menorrhagia (HP:0000132)2.06377029
90Abnormality of serum amino acid levels (HP:0003112)2.05922272
91Palpitations (HP:0001962)2.05909095
92Metaphyseal dysplasia (HP:0100255)2.05350174
93Symptomatic seizures (HP:0011145)2.04572038
94Congenital, generalized hypertrichosis (HP:0004540)2.02312131
95Reduced antithrombin III activity (HP:0001976)2.02249455
96White forelock (HP:0002211)2.01364866
97Small epiphyses (HP:0010585)1.99244381
98Hypoglycemic seizures (HP:0002173)1.98920522
99Abnormality of the ileum (HP:0001549)1.98580928
100Respiratory difficulties (HP:0002880)1.97355752
101X-linked dominant inheritance (HP:0001423)1.96451984
102Hyperinsulinemic hypoglycemia (HP:0000825)1.96293090
103Biliary tract neoplasm (HP:0100574)1.96045663
104Short middle phalanx of the 5th finger (HP:0004220)1.95189652
105Myelodysplasia (HP:0002863)1.95016093
106Abnormal spermatogenesis (HP:0008669)1.94628455
107IgG deficiency (HP:0004315)1.94393988
108Recurrent pneumonia (HP:0006532)1.94140527
109Increased serum lactate (HP:0002151)1.94081124
110Retrobulbar optic neuritis (HP:0100654)1.93889841
111Optic neuritis (HP:0100653)1.93889841
112Vasculitis (HP:0002633)1.92062124
113T lymphocytopenia (HP:0005403)1.91574371
114Spastic paraparesis (HP:0002313)1.91333847
115Small intestinal stenosis (HP:0012848)1.90780791
116Duodenal stenosis (HP:0100867)1.90780791
117IgM deficiency (HP:0002850)1.90573558
118Neurofibrillary tangles (HP:0002185)1.89537712
119Abnormal number of erythroid precursors (HP:0012131)1.87741781
120Abnormality of urine glucose concentration (HP:0011016)1.87113370
121Glycosuria (HP:0003076)1.87113370
122Thyroiditis (HP:0100646)1.85181426
123Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85156510
124Absent epiphyses (HP:0010577)1.85156510
125Autoimmune hemolytic anemia (HP:0001890)1.85137489
126Sparse eyelashes (HP:0000653)1.84875821
127Lactic acidosis (HP:0003128)1.82526570
128Ovarian neoplasm (HP:0100615)1.82210937
129Erythroderma (HP:0001019)1.81861741
130Abnormality of the labia minora (HP:0012880)1.81756405
131Abnormality of vitamin B metabolism (HP:0004340)1.81753860
132Colon cancer (HP:0003003)1.81279492
133Neoplasm of the adrenal gland (HP:0100631)1.81122879
134Delayed epiphyseal ossification (HP:0002663)1.81084273
135Abnormality of incisor morphology (HP:0011063)1.80279081
136Abnormality of the vitamin B12 metabolism (HP:0004341)1.80227687
137Abnormality of eosinophils (HP:0001879)1.79906078
138Thyroid carcinoma (HP:0002890)1.79797972
139Anhidrosis (HP:0000970)1.79116919
140Abnormal lung lobation (HP:0002101)1.78157292
141Megaloblastic anemia (HP:0001889)1.77611350
142Increased muscle lipid content (HP:0009058)1.77507959
143Epiphyseal dysplasia (HP:0002656)1.76219014
144Pheochromocytoma (HP:0002666)1.72924862
145Abnormality of sulfur amino acid metabolism (HP:0004339)1.72868267
146Agnosia (HP:0010524)1.72531709
147Hypomagnesemia (HP:0002917)1.71570930
148Stenosis of the external auditory canal (HP:0000402)1.71051238
149Increased intramyocellular lipid droplets (HP:0012240)1.70880279
150Prolonged neonatal jaundice (HP:0006579)1.70644442
151Barrel-shaped chest (HP:0001552)1.70260215
152Nephrogenic diabetes insipidus (HP:0009806)1.69659924
153Hypoplastic pelvis (HP:0008839)1.69095149
154Amniotic constriction ring (HP:0009775)1.66618959
155Abnormality of placental membranes (HP:0011409)1.66618959
156Hypokinesia (HP:0002375)1.66166533
157Hypergammaglobulinemia (HP:0010702)1.65712433
158Hypertensive crisis (HP:0100735)1.65360315
159Mediastinal lymphadenopathy (HP:0100721)1.64839505
160Combined immunodeficiency (HP:0005387)1.64565207
161Type I transferrin isoform profile (HP:0003642)1.64555011
162Peripheral hypomyelination (HP:0007182)1.64464699
163Congenital primary aphakia (HP:0007707)1.63659033
164Atonic seizures (HP:0010819)1.63219167
165Vaginal atresia (HP:0000148)1.62164990
166Petechiae (HP:0000967)1.60524039
167Decreased activity of mitochondrial respiratory chain (HP:0008972)1.59902221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.71582251
2STK392.92994924
3ZAK2.81970997
4BCR2.71355962
5VRK22.65637210
6TRIM282.41382187
7STK162.39624352
8CASK2.34782676
9OXSR12.31532565
10MAP3K122.28391729
11TXK2.28270809
12BMPR1B2.24777541
13MAP3K142.13629308
14NEK12.07867988
15CDC72.04856004
16BMPR22.00025506
17TTK1.95551049
18BUB11.94119666
19NUAK11.88102993
20ARAF1.87778815
21RIPK41.72633474
22TAF11.63235996
23VRK11.61182127
24EIF2AK11.58980986
25IRAK41.55317470
26WEE11.53446013
27NME11.48923800
28PIM21.48246403
29NME21.45247410
30TNIK1.42331817
31MAPKAPK51.37213265
32IRAK31.35936734
33STK31.35828034
34IKBKB1.33382335
35GRK71.33232490
36TEC1.30864126
37* MST41.30822197
38FRK1.29109248
39EIF2AK31.27644918
40EPHB11.26661555
41ADRBK21.23004014
42CDK191.22981412
43PKN11.21687913
44BLK1.19650033
45MAP4K21.19368500
46IKBKE1.19066271
47PLK11.16332150
48LIMK11.15875579
49NEK61.14531112
50PLK21.14506016
51YES11.12414682
52MKNK11.10769397
53DYRK31.06023618
54TBK11.05747539
55TAOK31.04439280
56PDK20.99146021
57MYLK0.97765208
58TSSK60.97553981
59MKNK20.97457566
60FGR0.96035404
61IRAK10.94157807
62WNK30.90834663
63PRPF4B0.90807108
64SCYL20.89431405
65STK100.87584881
66MUSK0.85285754
67PRKCQ0.83567004
68GRK50.82061315
69EIF2AK20.81884225
70CLK10.81510160
71DYRK20.81466926
72NLK0.77864606
73CSNK1G30.77065605
74CAMK2B0.76198795
75AURKB0.72553052
76AKT30.71892382
77LYN0.71602529
78ATR0.71024098
79RPS6KA50.70952057
80PRKCE0.70689048
81WNK40.70129061
82SYK0.70085680
83LCK0.69867053
84BRSK20.66331358
85ABL20.65855506
86MAP2K70.64495325
87ITK0.64120056
88ERBB30.63443158
89MAP4K10.61974227
90IRAK20.61729647
91ACVR1B0.59543070
92TRPM70.59367668
93ILK0.59041340
94PAK40.58306532
95CHEK20.56443145
96ROCK20.55283857
97CSNK1G10.53910079
98MAP3K130.53390513
99SRPK10.52606425
100DAPK10.51323026
101ATM0.51227327
102BMX0.51141300
103PNCK0.50407963
104BRSK10.50000112
105PRKCD0.49368765
106PLK30.48941283
107STK38L0.48059453
108CCNB10.47867898
109CAMK2D0.47532951
110CAMK2A0.47482963
111CSNK1A1L0.47463043
112ALK0.47143525
113CSNK2A20.46650162
114PIK3CG0.45802706
115MATK0.45595309
116RAF10.44832302
117MAP3K50.43147026
118PAK10.43135121
119BRAF0.42879275
120FER0.42663155
121GRK10.42520823
122TYK20.42423868
123TLK10.41749939
124KIT0.41518612
125FES0.40693876
126SIK30.40442004
127CSNK2A10.40212582
128CDK80.39977565
129CHEK10.39656944
130STK40.39333043
131JAK30.39252019
132CSK0.38856860
133RPS6KA40.38732655
134STK240.38425775
135BTK0.38185582
136ERBB40.38175289
137CAMK2G0.37729843
138PRKG10.35614463
139MAP3K80.35509903
140TGFBR10.35136758
141PLK40.35064343
142AURKA0.33341151
143PASK0.32981066
144PTK2B0.31425012
145FLT30.30023971
146MARK30.29908947
147DAPK30.29280141

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.06660311
2Proteasome_Homo sapiens_hsa030503.76990377
3Protein export_Homo sapiens_hsa030603.27053939
4Parkinsons disease_Homo sapiens_hsa050123.08709888
5Ribosome_Homo sapiens_hsa030102.71285503
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.62562164
7Graft-versus-host disease_Homo sapiens_hsa053322.54537290
8Alzheimers disease_Homo sapiens_hsa050102.45095465
9Collecting duct acid secretion_Homo sapiens_hsa049662.33223819
10Rheumatoid arthritis_Homo sapiens_hsa053232.32344139
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27540479
12Allograft rejection_Homo sapiens_hsa053302.26343124
13RNA polymerase_Homo sapiens_hsa030202.21533194
14Steroid biosynthesis_Homo sapiens_hsa001002.18742365
15Huntingtons disease_Homo sapiens_hsa050162.11036314
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93938911
17One carbon pool by folate_Homo sapiens_hsa006701.91236459
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80257880
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.78336465
20RNA transport_Homo sapiens_hsa030131.77871357
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75278170
22Autoimmune thyroid disease_Homo sapiens_hsa053201.71748207
23Propanoate metabolism_Homo sapiens_hsa006401.69153563
24Fatty acid elongation_Homo sapiens_hsa000621.60534992
25Type I diabetes mellitus_Homo sapiens_hsa049401.59832373
26Vibrio cholerae infection_Homo sapiens_hsa051101.59591627
27Phagosome_Homo sapiens_hsa041451.52904454
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.52797349
29Base excision repair_Homo sapiens_hsa034101.45433330
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41366143
31Cell cycle_Homo sapiens_hsa041101.40941184
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.39965770
33Asthma_Homo sapiens_hsa053101.37082643
34Ether lipid metabolism_Homo sapiens_hsa005651.36486840
35Primary immunodeficiency_Homo sapiens_hsa053401.25992689
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25518006
37Basal transcription factors_Homo sapiens_hsa030221.24246947
38Sphingolipid metabolism_Homo sapiens_hsa006001.22702510
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21628287
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17219278
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.16700800
42Hematopoietic cell lineage_Homo sapiens_hsa046401.08404526
43Malaria_Homo sapiens_hsa051441.08179519
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.05679841
45Pyruvate metabolism_Homo sapiens_hsa006201.03941751
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03614804
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00330659
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99938645
49Sulfur metabolism_Homo sapiens_hsa009200.99607122
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99275898
51Pertussis_Homo sapiens_hsa051330.99003533
52African trypanosomiasis_Homo sapiens_hsa051430.98298233
53Legionellosis_Homo sapiens_hsa051340.96389636
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94693207
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94078702
56Leishmaniasis_Homo sapiens_hsa051400.93737824
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91824879
58p53 signaling pathway_Homo sapiens_hsa041150.88749660
59Systemic lupus erythematosus_Homo sapiens_hsa053220.88141895
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87334125
61Measles_Homo sapiens_hsa051620.85161451
62Non-homologous end-joining_Homo sapiens_hsa034500.83438265
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82740745
64Nitrogen metabolism_Homo sapiens_hsa009100.80549234
65Salmonella infection_Homo sapiens_hsa051320.79991284
66Serotonergic synapse_Homo sapiens_hsa047260.78961543
67Pyrimidine metabolism_Homo sapiens_hsa002400.77606407
68Arachidonic acid metabolism_Homo sapiens_hsa005900.75436070
69Tuberculosis_Homo sapiens_hsa051520.74603179
70Folate biosynthesis_Homo sapiens_hsa007900.73840450
71Epstein-Barr virus infection_Homo sapiens_hsa051690.73788616
72Shigellosis_Homo sapiens_hsa051310.72054276
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70126592
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67474822
75Homologous recombination_Homo sapiens_hsa034400.67472546
76Oocyte meiosis_Homo sapiens_hsa041140.67196238
77Caffeine metabolism_Homo sapiens_hsa002320.66474029
78Regulation of autophagy_Homo sapiens_hsa041400.66014845
79Antigen processing and presentation_Homo sapiens_hsa046120.64105395
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64012995
81Nucleotide excision repair_Homo sapiens_hsa034200.63271173
82Selenocompound metabolism_Homo sapiens_hsa004500.62858240
83Peroxisome_Homo sapiens_hsa041460.61979321
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61561998
85Purine metabolism_Homo sapiens_hsa002300.59944940
86Lysosome_Homo sapiens_hsa041420.59830823
87Histidine metabolism_Homo sapiens_hsa003400.58463597
88Chemokine signaling pathway_Homo sapiens_hsa040620.58179405
89T cell receptor signaling pathway_Homo sapiens_hsa046600.56936397
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56403137
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55796896
92Cardiac muscle contraction_Homo sapiens_hsa042600.52903112
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51945292
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51769904
95Spliceosome_Homo sapiens_hsa030400.50566946
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48581922
97Mineral absorption_Homo sapiens_hsa049780.46574041
98Phototransduction_Homo sapiens_hsa047440.45512784
99mRNA surveillance pathway_Homo sapiens_hsa030150.44675233
100Carbon metabolism_Homo sapiens_hsa012000.44576807
101Herpes simplex infection_Homo sapiens_hsa051680.43668363
102Butanoate metabolism_Homo sapiens_hsa006500.43101813
103RNA degradation_Homo sapiens_hsa030180.41814027
104Platelet activation_Homo sapiens_hsa046110.41512463
105Synaptic vesicle cycle_Homo sapiens_hsa047210.41047058
106N-Glycan biosynthesis_Homo sapiens_hsa005100.40919111
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40337637
108Tryptophan metabolism_Homo sapiens_hsa003800.40289045
109Mismatch repair_Homo sapiens_hsa034300.40269139
110Linoleic acid metabolism_Homo sapiens_hsa005910.39633083
111Metabolic pathways_Homo sapiens_hsa011000.38238572
112Osteoclast differentiation_Homo sapiens_hsa043800.37495894
113Nicotine addiction_Homo sapiens_hsa050330.36358740
114Taste transduction_Homo sapiens_hsa047420.35340396
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35266374
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.35043675
117Fatty acid metabolism_Homo sapiens_hsa012120.34608981
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34496718
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33220162
120TNF signaling pathway_Homo sapiens_hsa046680.32886297
121Viral myocarditis_Homo sapiens_hsa054160.32008619
122Staphylococcus aureus infection_Homo sapiens_hsa051500.31838176
123Influenza A_Homo sapiens_hsa051640.31507185
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31181971
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30930509
126Other glycan degradation_Homo sapiens_hsa005110.30916859
127Alcoholism_Homo sapiens_hsa050340.30849666
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.30420854
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.30303691
130Chemical carcinogenesis_Homo sapiens_hsa052040.30134642
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29965109
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29938301
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28907298
134Viral carcinogenesis_Homo sapiens_hsa052030.28103656
135Glutathione metabolism_Homo sapiens_hsa004800.27963122
136Fanconi anemia pathway_Homo sapiens_hsa034600.27913605
137Fatty acid degradation_Homo sapiens_hsa000710.27849807
138Vitamin B6 metabolism_Homo sapiens_hsa007500.26875855
139Hepatitis C_Homo sapiens_hsa051600.26692479
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26091223
141DNA replication_Homo sapiens_hsa030300.24103279
142Morphine addiction_Homo sapiens_hsa050320.23061095
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.21736522

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