PDCD1LG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.18863706
2antigen processing and presentation of endogenous antigen (GO:0019883)5.79184445
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.05073154
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.05073154
5regulation of activation of Janus kinase activity (GO:0010533)4.89781543
6regulation of dendritic cell antigen processing and presentation (GO:0002604)4.85528549
7positive regulation of antigen processing and presentation (GO:0002579)4.72239232
8T-helper 1 type immune response (GO:0042088)4.62955808
9positive regulation of interleukin-12 production (GO:0032735)4.57278315
10negative thymic T cell selection (GO:0045060)4.54165785
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.53355454
12NIK/NF-kappaB signaling (GO:0038061)4.53172174
13regulation of T-helper 1 cell differentiation (GO:0045625)4.53096454
14positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.44710291
15virion attachment to host cell (GO:0019062)4.42387435
16adhesion of symbiont to host cell (GO:0044650)4.42387435
17cell adhesion mediated by integrin (GO:0033627)4.40705068
18positive regulation of natural killer cell differentiation (GO:0032825)4.38792833
19neutrophil activation involved in immune response (GO:0002283)4.37710515
20myeloid dendritic cell differentiation (GO:0043011)4.37210382
21negative T cell selection (GO:0043383)4.26048752
22positive regulation of interferon-alpha production (GO:0032727)4.23381306
23positive regulation of T-helper cell differentiation (GO:0045624)4.19361808
24natural killer cell mediated cytotoxicity (GO:0042267)4.19343045
25natural killer cell mediated immunity (GO:0002228)4.19343045
26positive regulation of alpha-beta T cell proliferation (GO:0046641)4.18212899
27cellular response to type I interferon (GO:0071357)4.08385790
28type I interferon signaling pathway (GO:0060337)4.08385790
29response to type I interferon (GO:0034340)4.05208004
30regulation of interleukin-12 biosynthetic process (GO:0045075)4.04359719
31regulation of antigen processing and presentation (GO:0002577)4.04112193
32regulation of hypersensitivity (GO:0002883)4.03712218
33myeloid dendritic cell activation (GO:0001773)4.02373967
34immunoglobulin mediated immune response (GO:0016064)4.02065301
35regulation of alpha-beta T cell proliferation (GO:0046640)4.01776303
36regulation of interferon-alpha production (GO:0032647)4.01775171
37antigen processing and presentation via MHC class Ib (GO:0002475)4.01630153
38regulation of mononuclear cell migration (GO:0071675)4.01168266
39positive regulation of interleukin-2 production (GO:0032743)3.96493363
40regulation of RIG-I signaling pathway (GO:0039535)3.96400005
41positive regulation of gamma-delta T cell activation (GO:0046645)3.95157033
42skin morphogenesis (GO:0043589)3.90836128
43cellular response to zinc ion (GO:0071294)3.88238565
44regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.86503362
45positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.82572878
46interferon-gamma-mediated signaling pathway (GO:0060333)3.82179405
47positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.81509820
48endodermal cell differentiation (GO:0035987)3.78894332
49positive regulation of type 2 immune response (GO:0002830)3.78210253
50defense response to protozoan (GO:0042832)3.77672555
51adhesion of symbiont to host (GO:0044406)3.76617207
52regulation of T-helper cell differentiation (GO:0045622)3.75104973
53positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.72137317
54positive regulation of humoral immune response (GO:0002922)3.70584846
55substrate-dependent cell migration (GO:0006929)3.69112491
56JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.68232688
57protein localization to endosome (GO:0036010)3.66148539
58neutrophil activation (GO:0042119)3.61996741
59regulation of vitamin D biosynthetic process (GO:0060556)3.61883370
60granulocyte activation (GO:0036230)3.61445107
61dendritic cell differentiation (GO:0097028)3.59810858
62positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.58857591
63regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.57486818
64regulation of interleukin-12 production (GO:0032655)3.56484276
65positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.55765847
66positive regulation of interleukin-17 production (GO:0032740)3.52973434
67B cell mediated immunity (GO:0019724)3.49192842
68regulation of memory T cell differentiation (GO:0043380)3.47708216
69regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.45900828
70regulation of T cell tolerance induction (GO:0002664)3.44798928
71regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.43870361
72cellular response to interferon-beta (GO:0035458)3.42424039
73T cell migration (GO:0072678)3.40764736
74response to muramyl dipeptide (GO:0032495)3.39248398
75positive regulation of activated T cell proliferation (GO:0042104)3.38980387
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.37183845
77natural killer cell activation (GO:0030101)3.36681915
78negative regulation of interleukin-12 production (GO:0032695)3.35995772
79collagen fibril organization (GO:0030199)3.32675208
80positive regulation of B cell differentiation (GO:0045579)3.32505542
81positive regulation of endothelial cell apoptotic process (GO:2000353)3.32265017
82regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.32144930
83regulation of T-helper 2 cell differentiation (GO:0045628)3.30986711
84regulation of immunoglobulin secretion (GO:0051023)3.30763928
85response to protozoan (GO:0001562)3.29371169
86growth hormone receptor signaling pathway (GO:0060396)3.29304951
87negative regulation of nitric oxide biosynthetic process (GO:0045019)3.29092167
88response to peptidoglycan (GO:0032494)3.25381168
89natural killer cell differentiation (GO:0001779)3.18455390
90positive regulation of interleukin-10 production (GO:0032733)3.18088872
91regulation of T-helper 1 type immune response (GO:0002825)3.15298020
92lymphocyte migration (GO:0072676)3.14250912
93T-helper cell differentiation (GO:0042093)3.12769375
94CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.12769375
95dendritic cell chemotaxis (GO:0002407)3.12043158
96wound healing, spreading of epidermal cells (GO:0035313)3.11166591
97positive regulation of T-helper 1 type immune response (GO:0002827)3.10917525
98negative regulation of interleukin-17 production (GO:0032700)3.10035557
99positive regulation of response to biotic stimulus (GO:0002833)3.09257238
100barbed-end actin filament capping (GO:0051016)3.07044200
101stress fiber assembly (GO:0043149)3.06981141
102cellular response to interferon-gamma (GO:0071346)3.06886972
103positive regulation of alpha-beta T cell differentiation (GO:0046638)3.06681741
104positive regulation of isotype switching (GO:0045830)3.06225288
105regulation of interleukin-2 biosynthetic process (GO:0045076)3.06111504
106regulation of B cell differentiation (GO:0045577)3.05951227
107positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.05037023
108apoptotic cell clearance (GO:0043277)3.02861197
109lipopolysaccharide-mediated signaling pathway (GO:0031663)3.02754412
110cellular response to interferon-alpha (GO:0035457)3.01683134
111response to interferon-beta (GO:0035456)2.99818252
112cellular response to vitamin (GO:0071295)2.99505116
113regulation of interferon-gamma biosynthetic process (GO:0045072)2.98650243
114interferon-gamma production (GO:0032609)2.98298070
115cellular response to vitamin D (GO:0071305)2.98286227
116thymic T cell selection (GO:0045061)2.98276135
117regulation of natural killer cell differentiation (GO:0032823)2.97970472
118positive regulation of T cell cytokine production (GO:0002726)2.96855821
119negative regulation of viral genome replication (GO:0045071)2.96452739
120response to interferon-gamma (GO:0034341)2.96259857
121lymphocyte chemotaxis (GO:0048247)2.96157571
122hyaluronan catabolic process (GO:0030214)2.94404856
123regulation of monocyte chemotaxis (GO:0090025)2.93730111
124regulation of macrophage chemotaxis (GO:0010758)2.93012964
125membrane raft organization (GO:0031579)2.92293878
126regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.90348479
127chondrocyte proliferation (GO:0035988)2.86760826
128protein heterotrimerization (GO:0070208)2.86647528
129positive regulation of chemokine biosynthetic process (GO:0045080)2.86447269
130positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.81990213
131regulation of type 2 immune response (GO:0002828)2.79574358
132regulation of chronic inflammatory response (GO:0002676)2.79109069
133collagen metabolic process (GO:0032963)2.76208551
134negative regulation of smooth muscle cell migration (GO:0014912)2.75729662
135positive regulation of macrophage cytokine production (GO:0060907)2.75109916
136regulation of membrane protein ectodomain proteolysis (GO:0051043)2.74607597
137type B pancreatic cell proliferation (GO:0044342)2.74508002
138regulation of vitamin metabolic process (GO:0030656)2.73740877
139regulation of cytokine secretion involved in immune response (GO:0002739)2.71605914
140collagen catabolic process (GO:0030574)2.70091182
141pinocytosis (GO:0006907)2.69271204
142hypotonic response (GO:0006971)2.67860477
143positive regulation of blood vessel endothelial cell migration (GO:0043536)2.66625723
144heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.65841310
145response to magnesium ion (GO:0032026)2.57977998
146phagocytosis, engulfment (GO:0006911)2.57551613
147fibril organization (GO:0097435)2.55785439
148response to vitamin D (GO:0033280)2.55490555
149regulation of chemokine biosynthetic process (GO:0045073)2.54571535
150regulation of early endosome to late endosome transport (GO:2000641)2.53624726
151positive regulation of Cdc42 GTPase activity (GO:0043089)2.51210431
152sequestering of extracellular ligand from receptor (GO:0035581)2.50861068
153decidualization (GO:0046697)2.50691884
154regulation of integrin-mediated signaling pathway (GO:2001044)2.50144508
155multicellular organismal macromolecule metabolic process (GO:0044259)2.48487248
156negative regulation of nitric-oxide synthase activity (GO:0051001)2.48106759
157negative regulation of monooxygenase activity (GO:0032769)2.47728540
158detection of molecule of bacterial origin (GO:0032490)2.47562465
159extracellular matrix assembly (GO:0085029)2.47055610
160regulation of macrophage cytokine production (GO:0010935)2.46688010
161chronic inflammatory response (GO:0002544)2.45902792
162keratan sulfate catabolic process (GO:0042340)2.45116502
163positive regulation of leukocyte chemotaxis (GO:0002690)2.44877566
164multicellular organismal catabolic process (GO:0044243)2.44328668
165hemidesmosome assembly (GO:0031581)2.43830284
166negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.42956118
167wound healing, spreading of cells (GO:0044319)2.42673921
168regulation of transforming growth factor beta1 production (GO:0032908)2.42406815
169extracellular matrix disassembly (GO:0022617)2.42177080
170cell migration involved in heart development (GO:0060973)2.41318713
171regulation of integrin activation (GO:0033623)2.39816240
172regulation of nitric oxide biosynthetic process (GO:0045428)2.36279681
173mesodermal cell differentiation (GO:0048333)2.35378786
174cell-substrate junction assembly (GO:0007044)2.34521776
175extracellular fibril organization (GO:0043206)2.33943986
176regulation of tolerance induction (GO:0002643)2.33710430
177multicellular organismal metabolic process (GO:0044236)2.33652759
178regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.33402617

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.44616422
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.49315774
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.30615002
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.50662518
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.17844271
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.12492183
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.16663155
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.78559511
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.71724576
10* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.51014158
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.39151913
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.37478415
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.33325649
14RARG_19884340_ChIP-ChIP_MEFs_Mouse3.31682510
15STAT4_19710469_ChIP-ChIP_TH1__Mouse3.30948320
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.29077066
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.14184392
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.97409325
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.94692678
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.61813638
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.50546886
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.50493711
23BRD4_25478319_ChIP-Seq_HGPS_Human2.36432698
24RUNX_20019798_ChIP-Seq_JUKART_Human2.31376272
25RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.25117648
26MYB_26560356_Chip-Seq_TH2_Human2.19265565
27SPI1_23547873_ChIP-Seq_NB4_Human2.11910912
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01501460
29MAF_26560356_Chip-Seq_TH1_Human2.01229561
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.99910384
31CJUN_26792858_Chip-Seq_BT549_Human1.97859791
32* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96854818
33CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.92096877
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.86164086
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84929647
36SCL_19346495_ChIP-Seq_HPC-7_Human1.81138210
37CLOCK_20551151_ChIP-Seq_293T_Human1.79767372
38* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.79135893
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78843256
40MYB_26560356_Chip-Seq_TH1_Human1.77829277
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75290657
42JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75238194
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72603298
44JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70406760
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68555440
46* VDR_24763502_ChIP-Seq_THP-1_Human1.65477694
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64640893
48GATA3_27048872_Chip-Seq_THYMUS_Human1.58900543
49* VDR_24787735_ChIP-Seq_THP-1_Human1.53443883
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51624624
51ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.50349477
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.49562876
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49090530
54SPI1_23127762_ChIP-Seq_K562_Human1.47346035
55PU_27001747_Chip-Seq_BMDM_Mouse1.46889620
56* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46122622
57GATA3_26560356_Chip-Seq_TH2_Human1.44972562
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44419034
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44137145
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42522028
61VDR_21846776_ChIP-Seq_THP-1_Human1.42518707
62* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40334784
63TP53_18474530_ChIP-ChIP_U2OS_Human1.40183644
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39693464
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39580263
66UBF1/2_26484160_Chip-Seq_HMECs_Human1.37090740
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36736004
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35781098
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.32727286
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.32140498
71SMC1_22415368_ChIP-Seq_MEFs_Mouse1.31765976
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30996064
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.29088708
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28255204
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.28179707
76* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26592071
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24583517
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24519648
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21388607
80* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21271587
81TP53_22127205_ChIP-Seq_IMR90_Human1.21157586
82TP53_16413492_ChIP-PET_HCT116_Human1.20496709
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18311240
84MAF_26560356_Chip-Seq_TH2_Human1.16871596
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16324879
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15491901
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10945210
88SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09326207
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08030544
90UTX_26944678_Chip-Seq_JUKART_Human1.07448592
91* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06671352
92P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05157897
93* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03420012
94TBX20_22328084_ChIP-Seq_HEART_Mouse1.01555064
95TBX20_22080862_ChIP-Seq_HEART_Mouse1.01555064
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01089648
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00735954
98IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99737673
99NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99693465
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99299799
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97362328
102SA1_22415368_ChIP-Seq_MEFs_Mouse0.97293567
103TCF7_22412390_ChIP-Seq_EML_Mouse0.95864724
104ESR1_21235772_ChIP-Seq_MCF-7_Human0.95262383
105GATA1_22025678_ChIP-Seq_K562_Human0.93168881
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92121138
107* GATA2_21666600_ChIP-Seq_HMVEC_Human0.91192967
108MYC_22102868_ChIP-Seq_BL_Human0.90512885
109SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90480344
110EGR1_19032775_ChIP-ChIP_M12_Human0.88595798
111* GATA1_19941827_ChIP-Seq_MEL_Mouse0.88556187
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88151342
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85509391
114GATA1_19941826_ChIP-Seq_K562_Human0.85508232
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85440045
116* TP63_23658742_ChIP-Seq_EP156T_Human0.85384534
117NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85325984
118TFEB_21752829_ChIP-Seq_HELA_Human0.84727547
119LXR_22292898_ChIP-Seq_THP-1_Human0.84352200
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83876941
121HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82427870
122CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81359245
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81261271
124PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80661966
125TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76988764
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76327931
127* SMRT_27268052_Chip-Seq_Bcells_Human0.76016776
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75532388
129ELK3_25401928_ChIP-Seq_HUVEC_Human0.73401384
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70617826
131EGR1_23403033_ChIP-Seq_LIVER_Mouse0.70549505
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70386631
133NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70386631
134SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.63673705
135SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.63637386
136SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.63637386
137ELF1_17652178_ChIP-ChIP_JURKAT_Human0.61143850
138HOXB4_20404135_ChIP-ChIP_EML_Mouse0.60117783
139TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.59583411
140KDM2B_26808549_Chip-Seq_DND41_Human0.59013491
141P300_27268052_Chip-Seq_Bcells_Human0.57286726
142CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.57199468
143CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.56943396
144SOX2_20726797_ChIP-Seq_SW620_Human0.56672579
145RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.56467992
146KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.55741258
147GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.54714962
148VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.54499521
149CDX2_19796622_ChIP-Seq_MESCs_Mouse0.53298016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.93403020
2* MP0001835_abnormal_antigen_presentation5.26256471
3MP0005671_abnormal_response_to4.46203239
4MP0000685_abnormal_immune_system4.11023813
5MP0002148_abnormal_hypersensitivity_rea3.98682264
6MP0009785_altered_susceptibility_to3.94811674
7MP0003705_abnormal_hypodermis_morpholog3.69659748
8MP0003279_aneurysm3.59249475
9MP0003436_decreased_susceptibility_to3.55749296
10MP0001348_abnormal_lacrimal_gland3.34038734
11MP0005387_immune_system_phenotype3.33531584
12MP0001790_abnormal_immune_system3.33531584
13* MP0005000_abnormal_immune_tolerance3.21512512
14MP0001958_emphysema3.00441038
15MP0006054_spinal_hemorrhage2.99618423
16* MP0005025_abnormal_response_to2.95521102
17MP0005275_abnormal_skin_tensile2.87079089
18* MP0001800_abnormal_humoral_immune2.84649692
19MP0004510_myositis2.77250748
20* MP0002452_abnormal_antigen_presenting2.72661825
21* MP0002723_abnormal_immune_serum2.70866626
22MP0002419_abnormal_innate_immunity2.65887391
23MP0002163_abnormal_gland_morphology2.65801838
24MP0006082_CNS_inflammation2.64780145
25MP0005310_abnormal_salivary_gland2.54058732
26MP0004272_abnormal_basement_membrane2.53046825
27MP0005257_abnormal_intraocular_pressure2.51501057
28MP0005623_abnormal_meninges_morphology2.47510073
29* MP0001819_abnormal_immune_cell2.46931772
30MP0003950_abnormal_plasma_membrane2.46407844
31MP0001542_abnormal_bone_strength2.43267258
32* MP0002420_abnormal_adaptive_immunity2.42696290
33MP0003303_peritoneal_inflammation2.38815744
34MP0002138_abnormal_hepatobiliary_system2.38784698
35MP0002405_respiratory_system_inflammati2.17635210
36MP0003724_increased_susceptibility_to2.11845023
37MP0005503_abnormal_tendon_morphology2.09186544
38MP0001853_heart_inflammation2.05346171
39MP0005023_abnormal_wound_healing2.04668692
40MP0002006_tumorigenesis2.02295555
41MP0001346_abnormal_lacrimal_gland1.99677673
42MP0002166_altered_tumor_susceptibility1.94197054
43MP0003763_abnormal_thymus_physiology1.93048050
44* MP0002398_abnormal_bone_marrow1.89905590
45* MP0000716_abnormal_immune_system1.88619381
46MP0009764_decreased_sensitivity_to1.87546544
47MP0010368_abnormal_lymphatic_system1.86957822
48MP0010155_abnormal_intestine_physiology1.85089294
49* MP0001845_abnormal_inflammatory_respons1.76684266
50MP0000767_abnormal_smooth_muscle1.75419754
51MP0002254_reproductive_system_inflammat1.74429391
52MP0009384_cardiac_valve_regurgitation1.72917339
53MP0004947_skin_inflammation1.66515250
54MP0005464_abnormal_platelet_physiology1.65893776
55MP0009333_abnormal_splenocyte_physiolog1.57779177
56MP0000858_altered_metastatic_potential1.56366837
57MP0005397_hematopoietic_system_phenotyp1.54539106
58MP0001545_abnormal_hematopoietic_system1.54539106
59* MP0003448_altered_tumor_morphology1.53090998
60MP0008469_abnormal_protein_level1.48874874
61MP0002295_abnormal_pulmonary_circulatio1.48556558
62* MP0002429_abnormal_blood_cell1.47665371
63MP0001533_abnormal_skeleton_physiology1.46582279
64MP0005379_endocrine/exocrine_gland_phen1.40414051
65MP0005164_abnormal_response_to1.39743644
66* MP0002722_abnormal_immune_system1.38638567
67MP0005451_abnormal_body_composition1.38201910
68MP0000689_abnormal_spleen_morphology1.38183265
69MP0005595_abnormal_vascular_smooth1.35630201
70MP0008004_abnormal_stomach_pH1.32726449
71MP0004808_abnormal_hematopoietic_stem1.25955031
72MP0001243_abnormal_dermal_layer1.24190915
73MP0003828_pulmonary_edema1.21535580
74MP0002060_abnormal_skin_morphology1.20416861
75MP0002896_abnormal_bone_mineralization1.16120858
76MP0003075_altered_response_to1.15548403
77MP0005165_increased_susceptibility_to1.13789267
78MP0001873_stomach_inflammation1.10389888
79MP0002332_abnormal_exercise_endurance1.10378634
80MP0008057_abnormal_DNA_replication1.09176107
81MP0005508_abnormal_skeleton_morphology1.02937596
82MP0003300_gastrointestinal_ulcer1.02710950
83MP0003866_abnormal_defecation1.01951795
84MP0001849_ear_inflammation0.97435162
85MP0004883_abnormal_blood_vessel0.97127779
86MP0002277_abnormal_respiratory_mucosa0.95323494
87MP0003091_abnormal_cell_migration0.94562164
88MP0000703_abnormal_thymus_morphology0.92990887
89MP0003186_abnormal_redox_activity0.91620064
90MP0003172_abnormal_lysosome_physiology0.90935292
91MP0000343_altered_response_to0.90732753
92MP0003191_abnormal_cellular_cholesterol0.89902192
93* MP0009763_increased_sensitivity_to0.89878603
94MP0010352_gastrointestinal_tract_polyps0.89812825
95MP0000733_abnormal_muscle_development0.87672595
96MP0002877_abnormal_melanocyte_morpholog0.87302390
97MP0003795_abnormal_bone_structure0.87159415
98MP0001879_abnormal_lymphatic_vessel0.84340334
99MP0002876_abnormal_thyroid_physiology0.83744149
100MP0002998_abnormal_bone_remodeling0.83435303
101MP0010307_abnormal_tumor_latency0.81271929
102MP0005166_decreased_susceptibility_to0.80868885
103MP0009840_abnormal_foam_cell0.78592645
104MP0002396_abnormal_hematopoietic_system0.78455702
105MP0003453_abnormal_keratinocyte_physiol0.76331560
106MP0005076_abnormal_cell_differentiation0.74763131
107MP0009765_abnormal_xenobiotic_induced0.74253353
108MP0005197_abnormal_uvea_morphology0.73890035
109MP0002168_other_aberrant_phenotype0.73833824
110MP0004782_abnormal_surfactant_physiolog0.73037550
111MP0000490_abnormal_crypts_of0.72713970
112MP0002933_joint_inflammation0.71917430
113MP0001915_intracranial_hemorrhage0.71330883
114MP0004858_abnormal_nervous_system0.71222131
115MP0000751_myopathy0.70056004
116MP0001881_abnormal_mammary_gland0.68990262
117MP0009278_abnormal_bone_marrow0.68117675
118MP0005058_abnormal_lysosome_morphology0.67300919
119MP0003941_abnormal_skin_development0.65753662
120MP0008260_abnormal_autophagy0.64243513
121MP0002019_abnormal_tumor_incidence0.63955900
122MP0002113_abnormal_skeleton_development0.62552896
123MP0000569_abnormal_digit_pigmentation0.62153440
124MP0001299_abnormal_eye_distance/0.61688277
125MP0000013_abnormal_adipose_tissue0.60903488
126MP0000750_abnormal_muscle_regeneration0.60895397
127MP0003045_fibrosis0.60720571
128MP0000604_amyloidosis0.58148621
129MP0000371_diluted_coat_color0.57931688
130MP0000627_abnormal_mammary_gland0.56881086
131MP0002136_abnormal_kidney_physiology0.56800694
132MP0005390_skeleton_phenotype0.56698282
133MP0000249_abnormal_blood_vessel0.53636139
134MP0002009_preneoplasia0.53392671
135MP0005174_abnormal_tail_pigmentation0.52161885
136MP0002132_abnormal_respiratory_system0.50937924
137* MP0002693_abnormal_pancreas_physiology0.50644598
138MP0000613_abnormal_salivary_gland0.49704090
139MP0003566_abnormal_cell_adhesion0.47732876
140MP0010386_abnormal_urinary_bladder0.42393292
141MP0003183_abnormal_peptide_metabolism0.40215841
142MP0005584_abnormal_enzyme/coenzyme_acti0.40102969
143MP0001663_abnormal_digestive_system0.39283736

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.52131605
2Increased IgM level (HP:0003496)6.29210154
3Eczematoid dermatitis (HP:0000976)6.04184275
4Protrusio acetabuli (HP:0003179)5.69109812
5Recurrent abscess formation (HP:0002722)5.40977859
6Gastrointestinal infarctions (HP:0005244)5.07857515
7Recurrent bacterial skin infections (HP:0005406)5.05574654
8Autoimmune thrombocytopenia (HP:0001973)4.95659264
9Chronic otitis media (HP:0000389)4.76731091
10Elevated erythrocyte sedimentation rate (HP:0003565)4.73629254
11Recurrent fungal infections (HP:0002841)4.49449540
12Myositis (HP:0100614)4.36339495
13Aortic dissection (HP:0002647)4.35849945
14Vasculitis (HP:0002633)4.27751565
15Mediastinal lymphadenopathy (HP:0100721)4.23016133
16Abnormality of glycolipid metabolism (HP:0010969)4.16499569
17Abnormality of liposaccharide metabolism (HP:0010968)4.16499569
18Abnormality of glycosphingolipid metabolism (HP:0004343)4.16499569
19Optic neuritis (HP:0100653)4.14174924
20Retrobulbar optic neuritis (HP:0100654)4.14174924
21Aortic aneurysm (HP:0004942)4.05763362
22Recurrent gram-negative bacterial infections (HP:0005420)4.01951616
23Recurrent cutaneous fungal infections (HP:0011370)3.98587633
24Chronic mucocutaneous candidiasis (HP:0002728)3.98587633
25Recurrent skin infections (HP:0001581)3.96813554
26Orchitis (HP:0100796)3.93123311
27Abnormality of macrophages (HP:0004311)3.89506700
28Abnormality of T cell number (HP:0011839)3.84390785
29Stomatitis (HP:0010280)3.83616235
30Hypergammaglobulinemia (HP:0010702)3.83419014
31Recurrent bronchitis (HP:0002837)3.76399253
32Atrophic scars (HP:0001075)3.76081624
33Spondylolisthesis (HP:0003302)3.75562714
34Vascular tortuosity (HP:0004948)3.70547862
35Ankle contracture (HP:0006466)3.65861548
36Recurrent viral infections (HP:0004429)3.65325605
37Thrombocytosis (HP:0001894)3.48369673
38Abnormal delayed hypersensitivity skin test (HP:0002963)3.45325333
39Follicular hyperkeratosis (HP:0007502)3.44493827
40Nasal polyposis (HP:0100582)3.42066830
41Arterial tortuosity (HP:0005116)3.34669967
42Autoimmune hemolytic anemia (HP:0001890)3.32507273
43Agammaglobulinemia (HP:0004432)3.27372639
44Arterial thrombosis (HP:0004420)3.25376258
45Basal ganglia calcification (HP:0002135)3.25058207
46Cervical subluxation (HP:0003308)3.24446597
47Soft skin (HP:0000977)3.20684540
48Leukocytosis (HP:0001974)3.19996133
49Gingival bleeding (HP:0000225)3.19503201
50Dilatation of the ascending aorta (HP:0005111)3.17001882
51Vertebral compression fractures (HP:0002953)3.16987396
52Gingivitis (HP:0000230)3.14283804
53Vacuolated lymphocytes (HP:0001922)3.12620056
54Type 1 muscle fiber predominance (HP:0003803)3.10773801
55Pulmonary infiltrates (HP:0002113)3.07896013
56Bladder diverticulum (HP:0000015)3.07198920
57Chronic obstructive pulmonary disease (HP:0006510)3.06766735
58Obstructive lung disease (HP:0006536)3.06766735
59T lymphocytopenia (HP:0005403)3.06500949
60Eosinophilia (HP:0001880)3.04011617
61IgG deficiency (HP:0004315)3.03640511
62Abnormality of T cells (HP:0002843)3.03024484
63Interstitial pulmonary disease (HP:0006530)3.00199590
64Dysostosis multiplex (HP:0000943)2.98742614
65Abnormality of eosinophils (HP:0001879)2.97074478
66Meningitis (HP:0001287)2.94141497
67Chronic diarrhea (HP:0002028)2.93166066
68Cellulitis (HP:0100658)2.91791253
69Spinal rigidity (HP:0003306)2.91188484
70Wormian bones (HP:0002645)2.89663978
71Abnormality of the nasal mucosa (HP:0000433)2.89531595
72Genu recurvatum (HP:0002816)2.89185116
73Fragile skin (HP:0001030)2.88956300
74Osteolytic defects of the hand bones (HP:0009699)2.88039192
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.88039192
76Chest pain (HP:0100749)2.87555330
77Amaurosis fugax (HP:0100576)2.86621218
78Abnormality of T cell physiology (HP:0011840)2.85373113
79IgA deficiency (HP:0002720)2.81819726
80Granulocytopenia (HP:0001913)2.76699886
81Blue sclerae (HP:0000592)2.75969044
82Hemoptysis (HP:0002105)2.75953798
83Abnormality of dentin (HP:0010299)2.75781504
84Chronic sinusitis (HP:0011109)2.72758004
85Severe combined immunodeficiency (HP:0004430)2.69516411
86Abnormality of cells of the lymphoid lineage (HP:0012140)2.66676362
87Thyroiditis (HP:0100646)2.65148003
88Slender build (HP:0001533)2.65075181
89Urinary glycosaminoglycan excretion (HP:0003541)2.61315871
90Mucopolysacchariduria (HP:0008155)2.61315871
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60772989
92Abnormality of polysaccharide metabolism (HP:0011012)2.60772989
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60772989
94Combined immunodeficiency (HP:0005387)2.56975370
95Myocardial infarction (HP:0001658)2.55796894
96Urticaria (HP:0001025)2.55686393
97Tetraparesis (HP:0002273)2.53763176
98Pustule (HP:0200039)2.52779937
99Increased IgE level (HP:0003212)2.50433297
100Gastrointestinal stroma tumor (HP:0100723)2.50207318
101Neonatal short-limb short stature (HP:0008921)2.49463197
102Cerebral aneurysm (HP:0004944)2.48730511
103Joint swelling (HP:0001386)2.48643084
104Periodontitis (HP:0000704)2.45262884
105Aortic regurgitation (HP:0001659)2.44045503
106Keratoconjunctivitis (HP:0001096)2.43239836
107Panhypogammaglobulinemia (HP:0003139)2.43151900
108Systemic lupus erythematosus (HP:0002725)2.41924032
109Keratoconjunctivitis sicca (HP:0001097)2.40939190
110Porencephaly (HP:0002132)2.40052182
111Lymphopenia (HP:0001888)2.39574767
112Peritonitis (HP:0002586)2.38595343
113Broad metatarsal (HP:0001783)2.35943057
114Fatigue (HP:0012378)2.35801890
115Anorexia (HP:0002039)2.35438624
116Encephalitis (HP:0002383)2.34935963
117Ovoid vertebral bodies (HP:0003300)2.34254772
118Joint stiffness (HP:0001387)2.33549361
119Thin bony cortex (HP:0002753)2.30099878
120Recurrent pneumonia (HP:0006532)2.29647161
121Aneurysm (HP:0002617)2.29576559
122Mitral valve prolapse (HP:0001634)2.27506712
123Gangrene (HP:0100758)2.26863396
124Inflammation of the large intestine (HP:0002037)2.26072930
125Mitral stenosis (HP:0001718)2.25762836
126Thick nail (HP:0001805)2.24666289
127Nuclear cataract (HP:0100018)2.23287254
128Arthralgia (HP:0002829)2.21181220
129Amyloidosis (HP:0011034)2.19972370
130Emphysema (HP:0002097)2.19037500
131Elbow flexion contracture (HP:0002987)2.18317231
132Petechiae (HP:0000967)2.17864157
133Recurrent lower respiratory tract infections (HP:0002783)2.17097637
134Spontaneous hematomas (HP:0007420)2.14931246
135Thoracolumbar scoliosis (HP:0002944)2.14156243
136Loss of speech (HP:0002371)2.13480730
137Gastrointestinal inflammation (HP:0004386)2.13292715
138Osteomyelitis (HP:0002754)2.12202496
139Cerebral ischemia (HP:0002637)2.11861789
140Exertional dyspnea (HP:0002875)2.10176079
141Mitral regurgitation (HP:0001653)2.08700463
142Sepsis (HP:0100806)2.08628904
143Hypochromic anemia (HP:0001931)2.07855290
144Increased variability in muscle fiber diameter (HP:0003557)2.07663477
145Abnormality of the acetabulum (HP:0003170)2.06895950
146Neutropenia (HP:0001875)2.05819865
147Colitis (HP:0002583)2.04515264
148Epistaxis (HP:0000421)2.04298934
149Hematochezia (HP:0002573)2.04197265
150Poor head control (HP:0002421)2.03821624
151Joint laxity (HP:0001388)2.03692856
152Recurrent sinusitis (HP:0011108)2.01919495
153Bowel diverticulosis (HP:0005222)1.98574594
154Hyperextensible skin (HP:0000974)1.97964822
155Overgrowth (HP:0001548)1.97448260
156Aortic valve stenosis (HP:0001650)1.96833175
157Biconcave vertebral bodies (HP:0004586)1.96063232
158Camptodactyly of toe (HP:0001836)1.94692307
159Femoral bowing (HP:0002980)1.94025779
160Asymmetric septal hypertrophy (HP:0001670)1.93471291
161Cardiovascular calcification (HP:0011915)1.91541144
162Mildly elevated creatine phosphokinase (HP:0008180)1.87879848
163Abnormality of skeletal muscle fiber size (HP:0012084)1.87447901
164Flared iliac wings (HP:0002869)1.86522392
165Shallow orbits (HP:0000586)1.85936233
166Achilles tendon contracture (HP:0001771)1.81769873
167Absent frontal sinuses (HP:0002688)1.81352271
168Short nail (HP:0001799)1.79164472
169Generalized amyotrophy (HP:0003700)1.78088648
170Flexion contracture of toe (HP:0005830)1.77988144
171Joint contractures involving the joints of the feet (HP:0100492)1.77988144
172Abnormal delivery (HP:0001787)1.77583608
173Neurofibrillary tangles (HP:0002185)1.76051858
174Pulmonary hypertension (HP:0002092)1.75517107
175Increased connective tissue (HP:0009025)1.74427103
176Axonal loss (HP:0003447)1.73452699
177Nonimmune hydrops fetalis (HP:0001790)1.73350046
178Natal tooth (HP:0000695)1.72724401
179Abnormality of the vasculature of the conjunctiva (HP:0008054)1.71445251
180Distal upper limb amyotrophy (HP:0007149)1.70956671
181Upper limb amyotrophy (HP:0009129)1.70956671
182Ectopia lentis (HP:0001083)1.69990272
183Round ear (HP:0100830)1.68957040
184Spinal cord lesions (HP:0100561)1.67567865
185Syringomyelia (HP:0003396)1.67567865
186Cupped ribs (HP:0000887)1.65650425
187Upper motor neuron abnormality (HP:0002127)1.64852798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.32670548
2PBK4.21446745
3DDR23.66581564
4TBK13.65954227
5MYLK3.57276657
6PIM23.54579821
7JAK33.47606935
8IKBKB3.18743126
9MAP3K133.11298592
10RIPK43.02237136
11IRAK32.95252219
12TYK22.91616861
13PDGFRA2.90104978
14BLK2.72906281
15IKBKE2.62216694
16MAP4K12.61251812
17TXK2.52153163
18TTN2.42341019
19IRAK42.29037895
20CHUK2.28594033
21LIMK12.20021795
22JAK12.12760687
23RIPK12.11351273
24TAOK21.84104701
25CDC42BPA1.83399466
26MST41.81677992
27NEK91.80580178
28EPHA31.75744848
29PTK21.72145645
30PAK21.71125871
31ZAP701.62041563
32EPHB11.61002924
33PIM11.60305924
34EPHB21.59737507
35LATS21.59207120
36PRPF4B1.55790742
37MAP3K31.55209224
38PAK41.52986393
39SYK1.52245744
40BTK1.46461276
41FGFR41.43981364
42STK41.38941981
43TEC1.34564209
44ARAF1.34446214
45KIT1.33264718
46JAK21.30947221
47BMPR21.21786499
48SIK31.19623802
49PRKD21.18257328
50NME21.15479292
51FGFR31.14503510
52LCK1.13548908
53BCR1.13174000
54HCK1.08807448
55NTRK11.07723533
56CSK1.03752175
57LYN1.02573405
58CSF1R0.91648512
59NLK0.91274023
60ABL20.89911414
61PRKCQ0.86811402
62IRAK10.83577160
63ITK0.79790459
64MATK0.79552376
65LRRK20.78853108
66BMX0.78682010
67ERBB40.76600296
68SIK10.76525497
69STK380.75414473
70ROCK20.73279813
71PRKG20.72395943
72ROCK10.71216618
73TRIB30.70378414
74MAPK70.69031779
75EIF2AK20.66604921
76MAP3K50.65584900
77PAK60.64773525
78PTK2B0.64346420
79RPS6KA20.61043311
80NUAK10.60583339
81ABL10.59193410
82PRKCD0.58657442
83TESK10.58298187
84TIE10.56904966
85SIK20.54255657
86MAPKAPK20.54161992
87STK100.53501776
88GSK3A0.52925350
89TAOK30.52388298
90RAF10.51692076
91FLT30.51595319
92DYRK1B0.51561626
93DAPK30.51492924
94ERBB30.51375173
95MET0.50291168
96TESK20.50096430
97ILK0.49938386
98CDK60.48193604
99PIK3CG0.47411637
100DMPK0.46879804
101PAK10.46622788
102YES10.44200956
103INSR0.43630341
104EGFR0.42848436
105MAP3K120.41538104
106KSR20.40651492
107MARK30.40321897
108RPS6KA40.40028415
109MELK0.39822821
110MAP3K60.39619630
111ADRBK20.38978565
112AKT30.37686943
113MAP2K30.37511311
114TGFBR10.36832391
115MAP3K80.35781235
116TAOK10.35352179
117MAP3K110.34910245
118MAP3K10.34381407
119ADRBK10.33394030
120GRK60.32972688
121LATS10.32719696
122TRPM70.32636558
123KDR0.31707878
124CAMK2G0.31026395
125ICK0.30533366
126ALK0.30206746
127FES0.28231603
128SCYL20.28115765
129ERN10.26698476
130PTK60.26555609
131MST1R0.25670195
132MOS0.25084975
133MAP3K90.24436911
134PKN10.23921520
135FGR0.23868215
136TGFBR20.21500246
137IGF1R0.20141006
138RPS6KA10.18806184
139PDGFRB0.18183257
140BMPR1B0.17815672
141CLK10.12754404
142SRC0.12328788
143MAPK30.11447246
144GRK70.10519578
145HIPK20.10274788
146FYN0.09873262
147PDK10.09441892

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.62644140
2Graft-versus-host disease_Homo sapiens_hsa053324.17280854
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.95368599
4Type I diabetes mellitus_Homo sapiens_hsa049402.86690516
5Autoimmune thyroid disease_Homo sapiens_hsa053202.82775164
6Leishmaniasis_Homo sapiens_hsa051402.77805598
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.67534280
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.62315709
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.52680738
10Measles_Homo sapiens_hsa051622.49456487
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.48866418
12Primary immunodeficiency_Homo sapiens_hsa053402.47715880
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.31490707
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.15696614
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14190076
16ECM-receptor interaction_Homo sapiens_hsa045121.98119319
17Legionellosis_Homo sapiens_hsa051341.97689615
18Osteoclast differentiation_Homo sapiens_hsa043801.92254140
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.91979909
20Influenza A_Homo sapiens_hsa051641.83383009
21Viral myocarditis_Homo sapiens_hsa054161.82558874
22Asthma_Homo sapiens_hsa053101.78297678
23TNF signaling pathway_Homo sapiens_hsa046681.77542488
24Pertussis_Homo sapiens_hsa051331.76771516
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.76692197
26African trypanosomiasis_Homo sapiens_hsa051431.74447888
27Toxoplasmosis_Homo sapiens_hsa051451.72904586
28B cell receptor signaling pathway_Homo sapiens_hsa046621.72784190
29Herpes simplex infection_Homo sapiens_hsa051681.72523176
30Antigen processing and presentation_Homo sapiens_hsa046121.68956823
31Focal adhesion_Homo sapiens_hsa045101.68204357
32Tuberculosis_Homo sapiens_hsa051521.66777352
33Malaria_Homo sapiens_hsa051441.63408703
34Rheumatoid arthritis_Homo sapiens_hsa053231.63236924
35Chemokine signaling pathway_Homo sapiens_hsa040621.63002975
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51779203
37Apoptosis_Homo sapiens_hsa042101.49495377
38Bladder cancer_Homo sapiens_hsa052191.46063774
39Hematopoietic cell lineage_Homo sapiens_hsa046401.35084369
40Staphylococcus aureus infection_Homo sapiens_hsa051501.32642791
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29525423
42Shigellosis_Homo sapiens_hsa051311.28865820
43T cell receptor signaling pathway_Homo sapiens_hsa046601.28815358
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28193202
45Salmonella infection_Homo sapiens_hsa051321.24350138
46Hepatitis B_Homo sapiens_hsa051611.10201118
47Prolactin signaling pathway_Homo sapiens_hsa049171.05566161
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96258336
49Acute myeloid leukemia_Homo sapiens_hsa052210.93747425
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91806363
51Phagosome_Homo sapiens_hsa041450.89230439
52Hepatitis C_Homo sapiens_hsa051600.88076230
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86401651
54Vibrio cholerae infection_Homo sapiens_hsa051100.86294201
55Lysosome_Homo sapiens_hsa041420.84698048
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83393741
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82925696
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78660817
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76027581
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.75893475
61Sulfur metabolism_Homo sapiens_hsa009200.74840665
62Epstein-Barr virus infection_Homo sapiens_hsa051690.74051567
63Dilated cardiomyopathy_Homo sapiens_hsa054140.72133681
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70507009
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69949742
66Sphingolipid metabolism_Homo sapiens_hsa006000.68598440
67PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67830757
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67766404
69Protein digestion and absorption_Homo sapiens_hsa049740.66868860
70Chronic myeloid leukemia_Homo sapiens_hsa052200.62576485
71Proteasome_Homo sapiens_hsa030500.57578414
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56151177
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.55869089
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52089566
75Viral carcinogenesis_Homo sapiens_hsa052030.51951712
76Galactose metabolism_Homo sapiens_hsa000520.51322860
77Melanoma_Homo sapiens_hsa052180.51257641
78Amoebiasis_Homo sapiens_hsa051460.51219360
79Pathways in cancer_Homo sapiens_hsa052000.51029324
80Platelet activation_Homo sapiens_hsa046110.50901438
81HTLV-I infection_Homo sapiens_hsa051660.49021607
82Pancreatic cancer_Homo sapiens_hsa052120.47667701
83Rap1 signaling pathway_Homo sapiens_hsa040150.47451591
84Renal cell carcinoma_Homo sapiens_hsa052110.45382324
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44745616
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.44685988
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.44261121
88p53 signaling pathway_Homo sapiens_hsa041150.41468066
89Small cell lung cancer_Homo sapiens_hsa052220.40368263
90TGF-beta signaling pathway_Homo sapiens_hsa043500.39140643
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30925727
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30735165
93Other glycan degradation_Homo sapiens_hsa005110.29051608
94VEGF signaling pathway_Homo sapiens_hsa043700.27968626
95Phenylalanine metabolism_Homo sapiens_hsa003600.26569972
96Prion diseases_Homo sapiens_hsa050200.25918439
97* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25637389
98MAPK signaling pathway_Homo sapiens_hsa040100.22563733
99FoxO signaling pathway_Homo sapiens_hsa040680.21891374
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.21329994
101HIF-1 signaling pathway_Homo sapiens_hsa040660.20802099
102Non-small cell lung cancer_Homo sapiens_hsa052230.18709153
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17893238
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16352818
105Regulation of autophagy_Homo sapiens_hsa041400.15854320
106Proteoglycans in cancer_Homo sapiens_hsa052050.15632440
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15323440
108Endocytosis_Homo sapiens_hsa041440.11631580
109Collecting duct acid secretion_Homo sapiens_hsa049660.11110917
110Prostate cancer_Homo sapiens_hsa052150.10142053
111Insulin resistance_Homo sapiens_hsa049310.09199858
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.09065937
113MicroRNAs in cancer_Homo sapiens_hsa052060.08854616
114Type II diabetes mellitus_Homo sapiens_hsa049300.08106625
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.07477764
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.06951465
117Adherens junction_Homo sapiens_hsa045200.06194122
118Complement and coagulation cascades_Homo sapiens_hsa046100.04660624
119Notch signaling pathway_Homo sapiens_hsa043300.04358447
120Renin-angiotensin system_Homo sapiens_hsa046140.04164101
121Inositol phosphate metabolism_Homo sapiens_hsa005620.02654017

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »