PDCD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.23957857
2viral transcription (GO:0019083)6.03379667
3translational termination (GO:0006415)5.87682024
4ribosomal small subunit biogenesis (GO:0042274)5.73404810
5ribosomal small subunit assembly (GO:0000028)5.70391283
6translational elongation (GO:0006414)5.22307930
7maturation of SSU-rRNA (GO:0030490)5.18322015
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.01027047
9protein targeting to ER (GO:0045047)4.87254712
10cotranslational protein targeting to membrane (GO:0006613)4.87028715
11translational initiation (GO:0006413)4.85350708
12nuclear pore complex assembly (GO:0051292)4.74548877
13ribosomal large subunit biogenesis (GO:0042273)4.65399559
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.65110959
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.63778472
16protein localization to endoplasmic reticulum (GO:0070972)4.61862551
17viral life cycle (GO:0019058)4.58264675
18cellular protein complex disassembly (GO:0043624)4.55876784
19formation of translation preinitiation complex (GO:0001731)4.41433992
20ribonucleoprotein complex biogenesis (GO:0022613)4.41312526
21DNA strand elongation involved in DNA replication (GO:0006271)4.30727649
22nuclear pore organization (GO:0006999)4.28793061
23folic acid-containing compound biosynthetic process (GO:0009396)4.24214615
24telomere maintenance via semi-conservative replication (GO:0032201)4.09730033
25DNA strand elongation (GO:0022616)4.03963149
26protein complex disassembly (GO:0043241)4.03928856
27ribosome assembly (GO:0042255)3.96145344
28ribosome biogenesis (GO:0042254)3.92597252
29regulation of translational fidelity (GO:0006450)3.89308455
30nucleobase biosynthetic process (GO:0046112)3.87661720
31DNA replication initiation (GO:0006270)3.84431119
32macromolecular complex disassembly (GO:0032984)3.83852910
33purine nucleobase biosynthetic process (GO:0009113)3.83154395
34rRNA processing (GO:0006364)3.81050505
35translation (GO:0006412)3.80892580
36negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.76864659
37mitotic chromosome condensation (GO:0007076)3.73147494
38rRNA metabolic process (GO:0016072)3.71742110
39nuclear-transcribed mRNA catabolic process (GO:0000956)3.62302651
40pseudouridine synthesis (GO:0001522)3.58267607
41DNA replication checkpoint (GO:0000076)3.58189491
42pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.56788462
43negative regulation of RNA splicing (GO:0033119)3.53270607
44pore complex assembly (GO:0046931)3.49787993
45telomere maintenance via recombination (GO:0000722)3.47923815
46DNA unwinding involved in DNA replication (GO:0006268)3.47788786
47cellular component biogenesis (GO:0044085)3.43447664
48mRNA catabolic process (GO:0006402)3.42443453
49DNA topological change (GO:0006265)3.42339485
50pteridine-containing compound biosynthetic process (GO:0042559)3.41931846
51folic acid metabolic process (GO:0046655)3.41625610
52pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.40565881
53proteasome assembly (GO:0043248)3.37207870
54heterochromatin organization (GO:0070828)3.36933901
55DNA replication-dependent nucleosome assembly (GO:0006335)3.35917665
56DNA replication-dependent nucleosome organization (GO:0034723)3.35917665
57spliceosomal snRNP assembly (GO:0000387)3.35049022
58RNA catabolic process (GO:0006401)3.35033634
59establishment of integrated proviral latency (GO:0075713)3.33741212
60oxidative phosphorylation (GO:0006119)3.30605494
61proline biosynthetic process (GO:0006561)3.28432687
62mitotic recombination (GO:0006312)3.25578062
63IMP biosynthetic process (GO:0006188)3.24464916
64ncRNA 3-end processing (GO:0043628)3.23893770
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.19189489
66rRNA modification (GO:0000154)3.18221381
67transcription from mitochondrial promoter (GO:0006390)3.18108728
68protein targeting to membrane (GO:0006612)3.15813284
69negative regulation of mRNA processing (GO:0050686)3.13791587
70mitotic metaphase plate congression (GO:0007080)3.12253844
71protein localization to kinetochore (GO:0034501)3.11382025
72telomere maintenance via telomere lengthening (GO:0010833)3.09725881
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08054203
74chromatin remodeling at centromere (GO:0031055)3.06174713
75pyrimidine nucleotide catabolic process (GO:0006244)3.02030933
76kinetochore organization (GO:0051383)3.00051078
77CENP-A containing nucleosome assembly (GO:0034080)2.98170523
78mitotic sister chromatid segregation (GO:0000070)2.97142094
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96061863
80positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92791731
81rRNA transcription (GO:0009303)2.92744797
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.92739873
83negative regulation of mRNA metabolic process (GO:1903312)2.92557672
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91794051
85IMP metabolic process (GO:0046040)2.91612110
86peptidyl-histidine modification (GO:0018202)2.90932664
87mitotic nuclear envelope disassembly (GO:0007077)2.90140686
88viral mRNA export from host cell nucleus (GO:0046784)2.89781428
89transcription elongation from RNA polymerase III promoter (GO:0006385)2.89104413
90termination of RNA polymerase III transcription (GO:0006386)2.89104413
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89039676
92chromatin assembly or disassembly (GO:0006333)2.87814607
93DNA duplex unwinding (GO:0032508)2.87587588
94protein targeting to mitochondrion (GO:0006626)2.85827189
95DNA replication-independent nucleosome assembly (GO:0006336)2.85774125
96DNA replication-independent nucleosome organization (GO:0034724)2.85774125
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85150464
98negative regulation of ligase activity (GO:0051352)2.85150464
99sister chromatid segregation (GO:0000819)2.84769189
100termination of RNA polymerase II transcription (GO:0006369)2.82969936
101protein localization to chromosome, centromeric region (GO:0071459)2.81665171
102peptidyl-arginine omega-N-methylation (GO:0035247)2.81646777
103exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80387539
104ncRNA processing (GO:0034470)2.80098217
105DNA geometric change (GO:0032392)2.79886887
106spliceosomal complex assembly (GO:0000245)2.79817832
107chromatin assembly (GO:0031497)2.78671561
108transcription-coupled nucleotide-excision repair (GO:0006283)2.78051108
109tRNA aminoacylation for protein translation (GO:0006418)2.74502151
110ncRNA metabolic process (GO:0034660)2.73266593
111RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.72112221
112mRNA splicing, via spliceosome (GO:0000398)2.72112221
113nuclear envelope disassembly (GO:0051081)2.71597189
114membrane disassembly (GO:0030397)2.71597189
115tRNA aminoacylation (GO:0043039)2.71282756
116amino acid activation (GO:0043038)2.71282756
117RNA splicing, via transesterification reactions (GO:0000375)2.71000454
118mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.70758254
119pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.70046307
120respiratory chain complex IV assembly (GO:0008535)2.69012155
121regulation of mitochondrial translation (GO:0070129)2.67817993
122nucleobase-containing small molecule interconversion (GO:0015949)2.67751917
123somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.67335465
124isotype switching (GO:0045190)2.67335465
125somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67335465
126DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.67252639
127metaphase plate congression (GO:0051310)2.66508119
128G1/S transition of mitotic cell cycle (GO:0000082)2.63503660
129cell cycle G1/S phase transition (GO:0044843)2.63503660
130pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.63064890
131signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.62844573
132intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.62844573
133positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.62609087
134establishment of protein localization to mitochondrial membrane (GO:0090151)2.61836213
135transcription from RNA polymerase I promoter (GO:0006360)2.61384030
136signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.61252124

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.07395469
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.59670451
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.17523644
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.14199847
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03298716
6MYC_18358816_ChIP-ChIP_MESCs_Mouse2.99992605
7* GABP_17652178_ChIP-ChIP_JURKAT_Human2.98144588
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89779866
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.84889193
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83244516
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.80806196
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.74602395
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64437885
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50306900
15XRN2_22483619_ChIP-Seq_HELA_Human2.49097075
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.47114364
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30993646
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27668261
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26997071
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25397544
21* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20974719
22* VDR_23849224_ChIP-Seq_CD4+_Human2.19640519
23* DCP1A_22483619_ChIP-Seq_HELA_Human2.02179595
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01068092
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90170199
26* GABP_19822575_ChIP-Seq_HepG2_Human1.89252117
27FOXP3_21729870_ChIP-Seq_TREG_Human1.87382220
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.86780196
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.82400388
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80585970
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79400154
32TTF2_22483619_ChIP-Seq_HELA_Human1.76572955
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73473886
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72187741
35* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71338068
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68814188
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67571641
38* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66258800
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64248906
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.63033152
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62281571
42MYC_22102868_ChIP-Seq_BL_Human1.60234418
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.59952370
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57450938
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.48959363
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48126425
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47280993
48* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41234790
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40208520
50* SRF_21415370_ChIP-Seq_HL-1_Mouse1.39178060
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38804124
52ELK1_19687146_ChIP-ChIP_HELA_Human1.38642401
53AR_21909140_ChIP-Seq_LNCAP_Human1.38479591
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37423435
55KDM5A_27292631_Chip-Seq_BREAST_Human1.37030598
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36776425
57CIITA_25753668_ChIP-Seq_RAJI_Human1.35368876
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32897811
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28847732
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27779323
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27249897
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26571044
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24506852
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.23118817
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.21174528
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19475912
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19355341
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19065235
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17658735
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17558497
71VDR_21846776_ChIP-Seq_THP-1_Human1.17031278
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16197950
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15686241
74* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15372693
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14525109
76NCOR1_26117541_ChIP-Seq_K562_Human1.12615160
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12211479
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12140020
79TFEB_21752829_ChIP-Seq_HELA_Human1.11240398
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09717791
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09568473
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08470748
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07787216
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.05830000
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05252505
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02276267
87CHD1_26751641_Chip-Seq_LNCaP_Human1.02172851
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01732976
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01593169
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01556477
91OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99700664
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99132294
93ZNF263_19887448_ChIP-Seq_K562_Human0.98612552
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97164744
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96901471
96SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96620370
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95812287
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95650544
99MYC_18940864_ChIP-ChIP_HL60_Human0.95419071
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95343123
101SPI1_23547873_ChIP-Seq_NB4_Human0.95222155
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95123506
103* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95114446
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93892947
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92617870
106ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91549475
107* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91102008
108FOXP1_21924763_ChIP-Seq_HESCs_Human0.90628301
109SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90496123
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85830755
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85666229
112MAF_26560356_Chip-Seq_TH2_Human0.85119471
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83444100
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82227162
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81355545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003693_abnormal_embryo_hatching5.06360507
2* MP0004957_abnormal_blastocyst_morpholog4.72254014
3MP0003111_abnormal_nucleus_morphology3.73662294
4MP0003806_abnormal_nucleotide_metabolis3.72871594
5MP0010094_abnormal_chromosome_stability3.68558394
6MP0003077_abnormal_cell_cycle3.34825014
7MP0008007_abnormal_cellular_replicative2.56959647
8MP0008058_abnormal_DNA_repair2.56627204
9MP0000490_abnormal_crypts_of2.45733897
10MP0008932_abnormal_embryonic_tissue2.43822629
11MP0002877_abnormal_melanocyte_morpholog2.25403482
12MP0008057_abnormal_DNA_replication2.22244936
13MP0002396_abnormal_hematopoietic_system2.22190114
14MP0009379_abnormal_foot_pigmentation2.22169315
15MP0005451_abnormal_body_composition2.14135598
16* MP0001730_embryonic_growth_arrest2.13441923
17MP0000350_abnormal_cell_proliferation2.09815911
18MP0010352_gastrointestinal_tract_polyps2.07998734
19MP0009697_abnormal_copulation1.97127316
20MP0004185_abnormal_adipocyte_glucose1.89376626
21MP0009333_abnormal_splenocyte_physiolog1.82738100
22MP0000678_abnormal_parathyroid_gland1.78727083
23MP0003123_paternal_imprinting1.77640792
24MP0003186_abnormal_redox_activity1.76063602
25MP0003786_premature_aging1.75806384
26MP0003718_maternal_effect1.64067225
27MP0002163_abnormal_gland_morphology1.61379472
28MP0001697_abnormal_embryo_size1.59630259
29* MP0002080_prenatal_lethality1.52781917
30MP0010307_abnormal_tumor_latency1.51171184
31MP0002019_abnormal_tumor_incidence1.44902470
32* MP0001672_abnormal_embryogenesis/_devel1.44493422
33* MP0005380_embryogenesis_phenotype1.44493422
34MP0000313_abnormal_cell_death1.41161840
35MP0006036_abnormal_mitochondrial_physio1.40597829
36MP0001188_hyperpigmentation1.39754194
37MP0003763_abnormal_thymus_physiology1.38079730
38MP0009840_abnormal_foam_cell1.35602427
39MP0002086_abnormal_extraembryonic_tissu1.33550638
40MP0005076_abnormal_cell_differentiation1.31572781
41* MP0003984_embryonic_growth_retardation1.30241258
42MP0004197_abnormal_fetal_growth/weight/1.30234824
43* MP0002088_abnormal_embryonic_growth/wei1.28141996
44* MP0002085_abnormal_embryonic_tissue1.27611733
45MP0006292_abnormal_olfactory_placode1.27603219
46MP0002796_impaired_skin_barrier1.27314975
47MP0004808_abnormal_hematopoietic_stem1.22109757
48MP0004233_abnormal_muscle_weight1.19359667
49MP0005360_urolithiasis1.19109680
50MP0002234_abnormal_pharynx_morphology1.17782131
51MP0003941_abnormal_skin_development1.17419233
52MP0010030_abnormal_orbit_morphology1.17241831
53MP0000689_abnormal_spleen_morphology1.16600340
54MP0005397_hematopoietic_system_phenotyp1.16574556
55MP0001545_abnormal_hematopoietic_system1.16574556
56MP0002722_abnormal_immune_system1.15817906
57MP0005266_abnormal_metabolism1.15718823
58MP0003567_abnormal_fetal_cardiomyocyte1.15622443
59MP0002398_abnormal_bone_marrow1.15577980
60MP0003315_abnormal_perineum_morphology1.15462023
61MP0004147_increased_porphyrin_level1.12947966
62MP0000703_abnormal_thymus_morphology1.12136208
63MP0002084_abnormal_developmental_patter1.11343015
64MP0000358_abnormal_cell_content/1.11105365
65MP0000477_abnormal_intestine_morphology1.09277166
66MP0001727_abnormal_embryo_implantation1.02188971
67MP0008995_early_reproductive_senescence1.00115807
68MP0004133_heterotaxia0.99599739
69MP0001145_abnormal_male_reproductive0.98814045
70MP0002429_abnormal_blood_cell0.97783344
71MP0005085_abnormal_gallbladder_physiolo0.95327670
72MP0001881_abnormal_mammary_gland0.94608141
73MP0001849_ear_inflammation0.94432075
74MP0002210_abnormal_sex_determination0.93982428
75MP0000750_abnormal_muscle_regeneration0.92975281
76MP0000598_abnormal_liver_morphology0.92177070
77MP0001661_extended_life_span0.90582284
78MP0005220_abnormal_exocrine_pancreas0.90149896
79MP0002139_abnormal_hepatobiliary_system0.89897490
80MP0003221_abnormal_cardiomyocyte_apopto0.89595244
81MP0003656_abnormal_erythrocyte_physiolo0.88834879
82MP0006035_abnormal_mitochondrial_morpho0.88777322
83MP0010155_abnormal_intestine_physiology0.88717916
84MP0001293_anophthalmia0.88303013
85MP0000858_altered_metastatic_potential0.87862757
86MP0001873_stomach_inflammation0.87194642
87MP0009053_abnormal_anal_canal0.84711508
88MP0001764_abnormal_homeostasis0.84531973
89MP0005084_abnormal_gallbladder_morpholo0.84149205
90MP0002697_abnormal_eye_size0.83889040
91MP0010234_abnormal_vibrissa_follicle0.83237066
92MP0005023_abnormal_wound_healing0.82834574
93MP0002009_preneoplasia0.82707481
94MP0000716_abnormal_immune_system0.81724032
95MP0005365_abnormal_bile_salt0.81384870
96MP0003866_abnormal_defecation0.80682403
97MP0000685_abnormal_immune_system0.80431846
98MP0005621_abnormal_cell_physiology0.80353061
99MP0000537_abnormal_urethra_morphology0.76972116
100MP0000653_abnormal_sex_gland0.76429907
101MP0002132_abnormal_respiratory_system0.75836597
102MP0005319_abnormal_enzyme/_coenzyme0.73253428
103MP0002160_abnormal_reproductive_system0.73108945
104MP0001800_abnormal_humoral_immune0.72966308
105MP0005379_endocrine/exocrine_gland_phen0.72654555
106MP0003937_abnormal_limbs/digits/tail_de0.72311927
107MP0002249_abnormal_larynx_morphology0.71964797
108MP0005083_abnormal_biliary_tract0.71790921
109MP0003699_abnormal_female_reproductive0.71275215
110MP0002111_abnormal_tail_morphology0.71235898
111MP0000609_abnormal_liver_physiology0.70212717
112MP0009672_abnormal_birth_weight0.69702411
113MP0001929_abnormal_gametogenesis0.69057415
114MP0009643_abnormal_urine_homeostasis0.68772269
115MP0005501_abnormal_skin_physiology0.67772507
116MP0001853_heart_inflammation0.67358185
117MP0005389_reproductive_system_phenotype0.66993074
118MP0003385_abnormal_body_wall0.66201944
119MP0005666_abnormal_adipose_tissue0.66121770
120MP0004264_abnormal_extraembryonic_tissu0.64313665
121MP0000371_diluted_coat_color0.63871009
122MP0001119_abnormal_female_reproductive0.62988588
123MP0005384_cellular_phenotype0.60876210
124MP0002638_abnormal_pupillary_reflex0.60582092
125MP0003890_abnormal_embryonic-extraembry0.60141177
126MP0002420_abnormal_adaptive_immunity0.59837301
127MP0005376_homeostasis/metabolism_phenot0.59660834
128MP0008873_increased_physiological_sensi0.59193151
129MP0001819_abnormal_immune_cell0.58880831
130MP0005075_abnormal_melanosome_morpholog0.58625467
131MP0000428_abnormal_craniofacial_morphol0.58421129
132MP0005671_abnormal_response_to0.58268444
133MP0009703_decreased_birth_body0.57577586
134MP0002092_abnormal_eye_morphology0.57041797
135MP0003943_abnormal_hepatobiliary_system0.56311753

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.97914223
2Abnormal number of erythroid precursors (HP:0012131)5.64259450
3Reticulocytopenia (HP:0001896)5.49812866
4Birth length less than 3rd percentile (HP:0003561)4.38182166
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.34568806
6Macrocytic anemia (HP:0001972)4.16524471
7Chromsome breakage (HP:0040012)4.08604019
8Pallor (HP:0000980)3.82437209
9Breast hypoplasia (HP:0003187)3.67990393
10Oral leukoplakia (HP:0002745)3.67882525
11Rough bone trabeculation (HP:0100670)3.37538496
12Multiple enchondromatosis (HP:0005701)3.32624373
13Aplastic anemia (HP:0001915)3.19028854
14Trismus (HP:0000211)3.04463637
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.00195320
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.00195320
17Microretrognathia (HP:0000308)2.96484127
18Hepatocellular necrosis (HP:0001404)2.95077673
19Hypobetalipoproteinemia (HP:0003563)2.92506260
20Carpal bone hypoplasia (HP:0001498)2.89207525
21Colon cancer (HP:0003003)2.88948532
22Truncus arteriosus (HP:0001660)2.85875417
23Hepatic necrosis (HP:0002605)2.85359197
24Progressive muscle weakness (HP:0003323)2.85040197
25Progressive external ophthalmoplegia (HP:0000590)2.84056275
26Increased serum lactate (HP:0002151)2.74909378
27Degeneration of anterior horn cells (HP:0002398)2.74556275
28Abnormality of the anterior horn cell (HP:0006802)2.74556275
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.68205962
30Cerebral hypomyelination (HP:0006808)2.60996407
31Mitochondrial inheritance (HP:0001427)2.60891440
32Increased CSF lactate (HP:0002490)2.57410917
33Acute necrotizing encephalopathy (HP:0006965)2.54081106
34Respiratory difficulties (HP:0002880)2.45135286
35Abnormal mitochondria in muscle tissue (HP:0008316)2.43577576
3611 pairs of ribs (HP:0000878)2.41291908
37Absent thumb (HP:0009777)2.40085636
38Abnormal trabecular bone morphology (HP:0100671)2.40055208
39Type I transferrin isoform profile (HP:0003642)2.39198503
40Abnormality of reticulocytes (HP:0004312)2.38803190
41Premature ovarian failure (HP:0008209)2.37777047
42Short middle phalanx of the 5th finger (HP:0004220)2.37041759
43Ependymoma (HP:0002888)2.33388295
44Thrombocytosis (HP:0001894)2.32257520
45Rhabdomyosarcoma (HP:0002859)2.31391971
46Patellar aplasia (HP:0006443)2.30076112
47Microvesicular hepatic steatosis (HP:0001414)2.29571246
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.28508119
49Septate vagina (HP:0001153)2.28381703
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.28107126
51Acute encephalopathy (HP:0006846)2.28071473
52Abnormal hemoglobin (HP:0011902)2.27978729
53Hyperthyroidism (HP:0000836)2.26121923
54Abnormality of pyrimidine metabolism (HP:0004353)2.25306328
55Hypertensive crisis (HP:0100735)2.24417168
56Petechiae (HP:0000967)2.24322464
57Squamous cell carcinoma (HP:0002860)2.23399902
58Selective tooth agenesis (HP:0001592)2.18720136
59Lipid accumulation in hepatocytes (HP:0006561)2.18615710
60Aplasia/Hypoplasia of the patella (HP:0006498)2.16095855
61IgM deficiency (HP:0002850)2.14312015
62Cleft eyelid (HP:0000625)2.12341008
63Dicarboxylic aciduria (HP:0003215)2.11888331
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11888331
65Renal Fanconi syndrome (HP:0001994)2.10723146
66Acute myeloid leukemia (HP:0004808)2.10131656
67Cerebral edema (HP:0002181)2.09623720
68Increased hepatocellular lipid droplets (HP:0006565)2.09409889
69Abnormal number of incisors (HP:0011064)2.09193624
70Lactic acidosis (HP:0003128)2.09099144
71Abnormality of the heme biosynthetic pathway (HP:0010472)2.09049675
72Rectal prolapse (HP:0002035)2.08749777
73Neoplasm of the pancreas (HP:0002894)2.08644593
74Aplasia/Hypoplasia of the thymus (HP:0010515)2.08216689
75Premature graying of hair (HP:0002216)2.06295333
76Seborrheic dermatitis (HP:0001051)2.04132638
77Abnormality of monocarboxylic acid metabolism (HP:0010996)2.03970967
78Cellular immunodeficiency (HP:0005374)2.03799971
79Abnormality of chromosome stability (HP:0003220)2.03226344
80Sparse lateral eyebrow (HP:0005338)2.02468420
81Pancytopenia (HP:0001876)2.02019706
82Abnormality of cochlea (HP:0000375)2.01274865
83CNS demyelination (HP:0007305)2.00441373
84Lethargy (HP:0001254)2.00360179
85Basal cell carcinoma (HP:0002671)1.99359229
86Secondary amenorrhea (HP:0000869)1.98937920
87Hypoparathyroidism (HP:0000829)1.98578996
88Abnormality of the tricuspid valve (HP:0001702)1.97204026
89Horseshoe kidney (HP:0000085)1.96684177
90Hypergonadotropic hypogonadism (HP:0000815)1.95639762
91Increased serum pyruvate (HP:0003542)1.95114414
92Sparse eyelashes (HP:0000653)1.93935540
93Poikiloderma (HP:0001029)1.93440748
94Triphalangeal thumb (HP:0001199)1.92049835
95Cutaneous melanoma (HP:0012056)1.91176419
96Respiratory failure (HP:0002878)1.91079067
97Acute lymphatic leukemia (HP:0006721)1.90471420
98Redundant skin (HP:0001582)1.90251673
99Meckel diverticulum (HP:0002245)1.89302619
100Aplasia/Hypoplasia of the uvula (HP:0010293)1.87794959
101Emotional lability (HP:0000712)1.87594039
102Reticulocytosis (HP:0001923)1.87420998
103Megaloblastic anemia (HP:0001889)1.86888034
104Atrophy/Degeneration involving motor neurons (HP:0007373)1.86258452
105Abnormality of homocysteine metabolism (HP:0010919)1.85874784
106Homocystinuria (HP:0002156)1.85874784
107Angiofibromas (HP:0010615)1.84673369
108Adenoma sebaceum (HP:0009720)1.84673369
109Abnormality of glycolysis (HP:0004366)1.83891129
110Abnormality of the preputium (HP:0100587)1.83163985
111Increased nuchal translucency (HP:0010880)1.82645730
112Overlapping toe (HP:0001845)1.82456073
113Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82388453
114Increased intramyocellular lipid droplets (HP:0012240)1.82315492
115Medulloblastoma (HP:0002885)1.82313907
116Increased muscle lipid content (HP:0009058)1.82275631
117Ragged-red muscle fibers (HP:0003200)1.81933574
118Gout (HP:0001997)1.81758874
119Nephroblastoma (Wilms tumor) (HP:0002667)1.80107250
120Diastasis recti (HP:0001540)1.79398502
121Abnormality of methionine metabolism (HP:0010901)1.79249241
122Absent radius (HP:0003974)1.78630220
123Progressive macrocephaly (HP:0004481)1.77589589
124Agnosia (HP:0010524)1.77174753
125Male infertility (HP:0003251)1.77022736
126Myelodysplasia (HP:0002863)1.75578367
127Self-mutilation (HP:0000742)1.75552422
128Abnormal protein glycosylation (HP:0012346)1.75461495
129Abnormal glycosylation (HP:0012345)1.75461495
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75461495
131Abnormal protein N-linked glycosylation (HP:0012347)1.75461495
132Death in infancy (HP:0001522)1.73888784
133Abnormality of the ileum (HP:0001549)1.73575402
134Bone marrow hypocellularity (HP:0005528)1.73493589
135Orthostatic hypotension (HP:0001278)1.73336003
136Missing ribs (HP:0000921)1.73243688
137Lymphoma (HP:0002665)1.71292695
138Depressed nasal ridge (HP:0000457)1.70726256
139Double outlet right ventricle (HP:0001719)1.70291321
140Congenital malformation of the right heart (HP:0011723)1.70291321
141Abnormal cartilage morphology (HP:0002763)1.70222595
142Exercise intolerance (HP:0003546)1.69896046
143Hypolipoproteinemia (HP:0010981)1.69337068
144Reduced antithrombin III activity (HP:0001976)1.68163847
145Testicular atrophy (HP:0000029)1.67479216
146Atresia of the external auditory canal (HP:0000413)1.67376454
147Embryonal renal neoplasm (HP:0011794)1.66823795
148Abnormality of small intestinal villus morphology (HP:0011472)1.65840786
149Villous atrophy (HP:0011473)1.65840786

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.01801609
2WEE13.84601666
3BUB13.69181387
4STK163.42287662
5CDC73.07780328
6TESK22.87910204
7SMG12.60552118
8EIF2AK12.47860911
9VRK22.40641298
10TLK12.24481259
11PBK2.19674212
12NEK22.15591190
13ACVR1B2.08929017
14TAF12.02522543
15DYRK32.02425942
16RPS6KB21.97363670
17SRPK11.94578229
18PIM21.91838238
19KDR1.79586670
20PLK11.66693339
21SCYL21.66421779
22VRK11.66354268
23TRIB31.61932007
24BRSK21.60648328
25EIF2AK31.60312889
26TSSK61.59383493
27EPHA21.57374671
28TTK1.50306383
29NEK11.49168179
30AURKB1.48085488
31CDK71.47674105
32BRAF1.44972408
33PASK1.42923384
34MAP3K81.41795592
35MAPKAPK31.39886162
36PLK41.38137670
37AURKA1.37518086
38ICK1.37126825
39ERN11.35058723
40MKNK11.34490049
41BCKDK1.33544097
42EEF2K1.27434719
43FLT31.22139623
44STK101.20246848
45PAK41.20043528
46MKNK21.20032106
47MAP2K21.18368459
48MAP4K11.17669112
49MATK1.16765496
50RPS6KA41.15559199
51PRPF4B1.10691063
52PRKG21.08612890
53DDR21.08607601
54CLK11.06120585
55MAP3K101.05134794
56LRRK21.04655139
57PDK21.04222448
58ATR1.02833987
59TGFBR11.02309970
60MAP3K110.99648047
61TESK10.97770383
62CDK40.93921226
63KSR20.93117369
64PIM10.91967817
65CHEK20.90982091
66PKN20.88445290
67NME10.86498181
68CDK80.86108176
69RAF10.86013929
70BRSK10.82673597
71ZAP700.82310567
72CSNK2A20.75670386
73GRK60.73458810
74CHEK10.72159159
75IRAK20.71426353
76PLK30.70312218
77PRKCI0.66921694
78ALK0.66292272
79DYRK20.64308660
80CSNK2A10.63572106
81LATS20.63236790
82ZAK0.62916670
83MST40.62628545
84CCNB10.62324380
85AKT20.62082499
86BRD40.61052559
87RPS6KA50.60041312
88CDK120.59696048
89PAK10.55355815
90CDK20.54570510
91ABL20.54497948
92LIMK10.53835549
93EIF2AK20.52719641
94NUAK10.52092401
95ARAF0.51369559
96CDK90.50501607
97ATM0.48079286
98TEC0.47008049
99CDK190.45808758
100MAP3K20.45563354
101MAPK110.45421922
102MAP3K10.45127508
103STK30.43449253
104DAPK30.42936173
105MTOR0.41976602
106MAP3K130.41232377
107IRAK40.40024352
108MAP3K30.38767539
109CDK60.38697046
110PAK20.37944520
111MAP3K140.37483319
112DYRK1B0.36994810
113STK40.36560031
114STK240.36264777
115JAK30.34060047
116MAP2K30.31800001
117ILK0.31653948
118MELK0.31098450
119CDK10.30234625
120CSNK1E0.29866750
121NEK90.29434264
122BTK0.29194982
123NLK0.28450595
124MAPK140.28106381
125TAOK20.27452413
126KIT0.26990062
127IRAK30.26913919
128MOS0.26135145
129CSK0.26117887
130LYN0.23909103

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.07534443
2DNA replication_Homo sapiens_hsa030304.28728362
3Mismatch repair_Homo sapiens_hsa034303.58667013
4Proteasome_Homo sapiens_hsa030503.35577998
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.28654228
6RNA polymerase_Homo sapiens_hsa030203.06143005
7Spliceosome_Homo sapiens_hsa030402.80377494
8One carbon pool by folate_Homo sapiens_hsa006702.52225041
9Nucleotide excision repair_Homo sapiens_hsa034202.49013375
10Pyrimidine metabolism_Homo sapiens_hsa002402.47080841
11RNA transport_Homo sapiens_hsa030132.42450320
12Base excision repair_Homo sapiens_hsa034102.35692766
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31106342
14Homologous recombination_Homo sapiens_hsa034402.15377033
15Sulfur relay system_Homo sapiens_hsa041222.06154281
16Cell cycle_Homo sapiens_hsa041101.83686787
17Folate biosynthesis_Homo sapiens_hsa007901.75852929
18RNA degradation_Homo sapiens_hsa030181.46749501
19Basal transcription factors_Homo sapiens_hsa030221.46566249
20Non-homologous end-joining_Homo sapiens_hsa034501.44654924
21Parkinsons disease_Homo sapiens_hsa050121.42839760
22Pentose phosphate pathway_Homo sapiens_hsa000301.42699536
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.37564024
24Selenocompound metabolism_Homo sapiens_hsa004501.29660739
25Fanconi anemia pathway_Homo sapiens_hsa034601.28093951
26Oxidative phosphorylation_Homo sapiens_hsa001901.26610103
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.25245997
28p53 signaling pathway_Homo sapiens_hsa041151.24530967
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22871186
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20071374
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16952846
32Biosynthesis of amino acids_Homo sapiens_hsa012301.14417059
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.13154379
34Huntingtons disease_Homo sapiens_hsa050161.09811362
35Purine metabolism_Homo sapiens_hsa002301.09032572
36Systemic lupus erythematosus_Homo sapiens_hsa053221.06477147
37mRNA surveillance pathway_Homo sapiens_hsa030151.04531756
38Protein export_Homo sapiens_hsa030601.03662604
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00227192
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98298863
41Thyroid cancer_Homo sapiens_hsa052160.97767362
42Carbon metabolism_Homo sapiens_hsa012000.97601651
43Vitamin B6 metabolism_Homo sapiens_hsa007500.96746958
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94616577
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91390140
46Chronic myeloid leukemia_Homo sapiens_hsa052200.91178956
47Pancreatic cancer_Homo sapiens_hsa052120.88227737
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86856019
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85193279
50Antigen processing and presentation_Homo sapiens_hsa046120.82420754
51Glutathione metabolism_Homo sapiens_hsa004800.80159836
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79161820
53Epstein-Barr virus infection_Homo sapiens_hsa051690.78382044
54Non-small cell lung cancer_Homo sapiens_hsa052230.77646398
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76240319
56Sulfur metabolism_Homo sapiens_hsa009200.74954276
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70249333
58N-Glycan biosynthesis_Homo sapiens_hsa005100.69826779
59Colorectal cancer_Homo sapiens_hsa052100.67222065
60Alzheimers disease_Homo sapiens_hsa050100.66334627
61Viral carcinogenesis_Homo sapiens_hsa052030.64738575
62Galactose metabolism_Homo sapiens_hsa000520.62971343
63Herpes simplex infection_Homo sapiens_hsa051680.62542988
64Fatty acid elongation_Homo sapiens_hsa000620.62531137
65Bladder cancer_Homo sapiens_hsa052190.60168212
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59544038
67Fructose and mannose metabolism_Homo sapiens_hsa000510.57844747
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57640928
69Primary immunodeficiency_Homo sapiens_hsa053400.55890682
70Metabolic pathways_Homo sapiens_hsa011000.55218106
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50117888
72B cell receptor signaling pathway_Homo sapiens_hsa046620.48454239
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46857057
74Pyruvate metabolism_Homo sapiens_hsa006200.46547296
75Chemical carcinogenesis_Homo sapiens_hsa052040.45781763
76Steroid biosynthesis_Homo sapiens_hsa001000.40625779
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39250227
78mTOR signaling pathway_Homo sapiens_hsa041500.37243854
79Peroxisome_Homo sapiens_hsa041460.36172419
80Fatty acid degradation_Homo sapiens_hsa000710.34693813
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33315908
82Arginine and proline metabolism_Homo sapiens_hsa003300.32920768
83Fat digestion and absorption_Homo sapiens_hsa049750.32767422
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.32336842
85HTLV-I infection_Homo sapiens_hsa051660.31843008
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31711010
87Small cell lung cancer_Homo sapiens_hsa052220.31092222
88MicroRNAs in cancer_Homo sapiens_hsa052060.30707105
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30318098
90Oocyte meiosis_Homo sapiens_hsa041140.30043559
91Apoptosis_Homo sapiens_hsa042100.28620219
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27961078
93Endometrial cancer_Homo sapiens_hsa052130.26790056
94Legionellosis_Homo sapiens_hsa051340.23825176
95VEGF signaling pathway_Homo sapiens_hsa043700.23766019
96Caffeine metabolism_Homo sapiens_hsa002320.22419329
97Lysine degradation_Homo sapiens_hsa003100.22353898
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22229567
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21920812
100Measles_Homo sapiens_hsa051620.21554431
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21035280
102Prostate cancer_Homo sapiens_hsa052150.20769977
103Retinol metabolism_Homo sapiens_hsa008300.20721590
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20264747
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19234781
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18921095
107Propanoate metabolism_Homo sapiens_hsa006400.18840790
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18363542
109Melanoma_Homo sapiens_hsa052180.18014755
110Acute myeloid leukemia_Homo sapiens_hsa052210.17714502
111Linoleic acid metabolism_Homo sapiens_hsa005910.16344042
112Regulation of autophagy_Homo sapiens_hsa041400.16208071
113Cardiac muscle contraction_Homo sapiens_hsa042600.15523372
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15506293
115Tryptophan metabolism_Homo sapiens_hsa003800.14627788
116Alcoholism_Homo sapiens_hsa050340.13722570
117Shigellosis_Homo sapiens_hsa051310.13567409
118Hepatitis B_Homo sapiens_hsa051610.13380837
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12858542
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.12670104
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.12443340
122beta-Alanine metabolism_Homo sapiens_hsa004100.12331330
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11627989

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