PDCD5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1otic vesicle formation (GO:0030916)9.62453683
2establishment of protein localization to mitochondrial membrane (GO:0090151)6.47660084
3limb bud formation (GO:0060174)6.01942401
4chaperone-mediated protein transport (GO:0072321)5.80509446
5maturation of SSU-rRNA (GO:0030490)5.77784823
6prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.54754259
7viral transcription (GO:0019083)5.54491634
8ribosomal small subunit biogenesis (GO:0042274)5.28082721
9translational termination (GO:0006415)5.23807908
10regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.08192041
11ribosomal small subunit assembly (GO:0000028)5.00924274
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.88685639
13ATP synthesis coupled proton transport (GO:0015986)4.79696182
14energy coupled proton transport, down electrochemical gradient (GO:0015985)4.79696182
15lens fiber cell development (GO:0070307)4.76370732
16central nervous system myelination (GO:0022010)4.53303353
17axon ensheathment in central nervous system (GO:0032291)4.53303353
18translational elongation (GO:0006414)4.44096741
19cysteine metabolic process (GO:0006534)4.41796138
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.34964295
21protein targeting to ER (GO:0045047)4.30489501
22cotranslational protein targeting to membrane (GO:0006613)4.29516628
23behavioral response to nicotine (GO:0035095)4.24527060
24establishment of protein localization to endoplasmic reticulum (GO:0072599)4.12098394
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.08731203
26mitochondrial respiratory chain complex I assembly (GO:0032981)4.08731203
27NADH dehydrogenase complex assembly (GO:0010257)4.08731203
28protein localization to endoplasmic reticulum (GO:0070972)4.01936972
29viral life cycle (GO:0019058)4.01414130
30protein complex biogenesis (GO:0070271)3.98101547
31pattern specification involved in kidney development (GO:0061004)3.97486323
32protein neddylation (GO:0045116)3.91091277
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.89171368
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.89171368
35water-soluble vitamin biosynthetic process (GO:0042364)3.89112771
36GTP biosynthetic process (GO:0006183)3.86977130
37lung-associated mesenchyme development (GO:0060484)3.86262596
38lateral sprouting from an epithelium (GO:0060601)3.80470823
39cellular protein complex disassembly (GO:0043624)3.77300431
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.74632772
41heart valve formation (GO:0003188)3.74513077
42epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.61569637
43translational initiation (GO:0006413)3.59803053
44mitochondrial respiratory chain complex assembly (GO:0033108)3.54063978
45respiratory electron transport chain (GO:0022904)3.53903055
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.52244832
47digestive tract morphogenesis (GO:0048546)3.49928300
48electron transport chain (GO:0022900)3.49910461
49positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.47694054
50mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.47694054
51cellular component biogenesis (GO:0044085)3.45964311
52ribonucleoprotein complex biogenesis (GO:0022613)3.45653119
53homocysteine metabolic process (GO:0050667)3.42388442
54forebrain neuron development (GO:0021884)3.32456556
55lung lobe morphogenesis (GO:0060463)3.30159809
56intracellular protein transmembrane import (GO:0044743)3.27351667
57UTP biosynthetic process (GO:0006228)3.22948653
58ribosomal large subunit biogenesis (GO:0042273)3.15660952
59branching involved in salivary gland morphogenesis (GO:0060445)3.14180521
60presynaptic membrane assembly (GO:0097105)3.13346062
61purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.12534570
62prostate gland growth (GO:0060736)3.12364417
63cochlea development (GO:0090102)3.12189448
64purine nucleoside triphosphate biosynthetic process (GO:0009145)3.11593333
65pseudouridine synthesis (GO:0001522)3.11554006
66photoreceptor cell differentiation (GO:0046530)3.08468776
67eye photoreceptor cell differentiation (GO:0001754)3.08468776
68signal peptide processing (GO:0006465)3.07674177
69protein complex disassembly (GO:0043241)3.07590626
70cranial suture morphogenesis (GO:0060363)3.05887898
71guanosine-containing compound biosynthetic process (GO:1901070)3.05783894
72appendage development (GO:0048736)3.03456658
73limb development (GO:0060173)3.03456658
74translation (GO:0006412)3.01773536
75ribosome biogenesis (GO:0042254)3.00595202
76positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.99529556
77negative regulation of astrocyte differentiation (GO:0048712)2.98754765
78macromolecular complex disassembly (GO:0032984)2.89995287
79ATP biosynthetic process (GO:0006754)2.89026394
80protein targeting to membrane (GO:0006612)2.88940181
81CTP metabolic process (GO:0046036)2.87625140
82CTP biosynthetic process (GO:0006241)2.87625140
83neuronal stem cell maintenance (GO:0097150)2.86936175
84purine nucleotide salvage (GO:0032261)2.83619724
85nephron tubule formation (GO:0072079)2.83043569
86UTP metabolic process (GO:0046051)2.82046915
87central nervous system neuron development (GO:0021954)2.81534373
88branching involved in prostate gland morphogenesis (GO:0060442)2.78558253
89regulation of mitochondrial translation (GO:0070129)2.78244536
90rRNA processing (GO:0006364)2.77647454
91male meiosis I (GO:0007141)2.76585940
92chaperone-mediated protein complex assembly (GO:0051131)2.75517466
93ribonucleoside triphosphate biosynthetic process (GO:0009201)2.75486380
94positive regulation of RNA splicing (GO:0033120)2.75428509
95negative regulation of membrane potential (GO:0045837)2.74511681
96presynaptic membrane organization (GO:0097090)2.72165185
97rRNA metabolic process (GO:0016072)2.70990103
98nuclear-transcribed mRNA catabolic process (GO:0000956)2.70619814
99tongue development (GO:0043586)2.69425901
100cell proliferation in forebrain (GO:0021846)2.67867618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.43074925
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30560906
3VDR_22108803_ChIP-Seq_LS180_Human3.12900347
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.88250968
5BMI1_23680149_ChIP-Seq_NPCS_Mouse2.81036253
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78657144
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77855685
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.72643692
9FUS_26573619_Chip-Seq_HEK293_Human2.52927256
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38424728
11TAF15_26573619_Chip-Seq_HEK293_Human2.33678225
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.33421720
13RNF2_27304074_Chip-Seq_NSC_Mouse2.30138052
14POU5F1_16153702_ChIP-ChIP_HESCs_Human2.27953294
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27742745
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.23182552
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.16576459
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.16071303
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12527025
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12279151
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.10477337
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.08884930
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.08752973
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.94087412
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91457347
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91457347
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90698507
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87998146
29ZNF274_21170338_ChIP-Seq_K562_Hela1.84521803
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82537399
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.81882938
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80405569
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77837213
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77386258
35EWS_26573619_Chip-Seq_HEK293_Human1.77261095
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76283066
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69355070
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62371598
39P300_19829295_ChIP-Seq_ESCs_Human1.61239455
40TP53_22573176_ChIP-Seq_HFKS_Human1.57645860
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.55678252
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54352461
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53397609
44TP53_20018659_ChIP-ChIP_R1E_Mouse1.53326926
45XRN2_22483619_ChIP-Seq_HELA_Human1.47287339
46GBX2_23144817_ChIP-Seq_PC3_Human1.46795400
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46679205
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.35809830
49RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29020229
50TTF2_22483619_ChIP-Seq_HELA_Human1.28616985
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.28386256
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26527819
53BCAT_22108803_ChIP-Seq_LS180_Human1.25645680
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24328854
55ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24148303
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23839064
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23379310
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22243581
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21529039
60AR_21572438_ChIP-Seq_LNCaP_Human1.20364724
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18793639
62ELK1_19687146_ChIP-ChIP_HELA_Human1.16871149
63CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14287664
64P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14192169
65VDR_23849224_ChIP-Seq_CD4+_Human1.13921049
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.13655206
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10776119
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10609632
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10102191
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09851798
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09851798
72SOX2_19829295_ChIP-Seq_ESCs_Human1.09060155
73NANOG_19829295_ChIP-Seq_ESCs_Human1.09060155
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08527501
75FOXP3_21729870_ChIP-Seq_TREG_Human1.07677250
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06424865
77MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03635628
78NCOR_22424771_ChIP-Seq_293T_Human1.01755194
79SOX2_16153702_ChIP-ChIP_HESCs_Human0.98301344
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97864274
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97162194
82REST_18959480_ChIP-ChIP_MESCs_Mouse0.96169077
83TAF2_19829295_ChIP-Seq_ESCs_Human0.95724461
84MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95326889
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94640166
86FLI1_21867929_ChIP-Seq_TH2_Mouse0.94261722
87RING1B_27294783_Chip-Seq_ESCs_Mouse0.93495233
88AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93169076
89FOXH1_21741376_ChIP-Seq_EPCs_Human0.92986661
90MYC_18940864_ChIP-ChIP_HL60_Human0.92804842
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92290021
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91646164
93ER_23166858_ChIP-Seq_MCF-7_Human0.90474354
94ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89814537
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.89321718
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87546920
97CBP_20019798_ChIP-Seq_JUKART_Human0.87546920
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87387916
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86215900
100SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85640802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis8.21173723
2MP0003136_yellow_coat_color5.02668203
3MP0006292_abnormal_olfactory_placode3.53288056
4MP0005670_abnormal_white_adipose3.34720090
5MP0000537_abnormal_urethra_morphology3.04947103
6MP0010030_abnormal_orbit_morphology2.58654453
7MP0002282_abnormal_trachea_morphology2.24696415
8MP0009379_abnormal_foot_pigmentation2.18367244
9MP0001346_abnormal_lacrimal_gland2.09357829
10MP0002249_abnormal_larynx_morphology1.97783904
11MP0002089_abnormal_postnatal_growth/wei1.92591607
12MP0002638_abnormal_pupillary_reflex1.91578457
13MP0004885_abnormal_endolymph1.89629051
14MP0004142_abnormal_muscle_tone1.84210334
15MP0009780_abnormal_chondrocyte_physiolo1.79095010
16MP0000631_abnormal_neuroendocrine_gland1.76292049
17MP0000049_abnormal_middle_ear1.75074040
18MP0001299_abnormal_eye_distance/1.68468325
19MP0003122_maternal_imprinting1.57063784
20MP0002837_dystrophic_cardiac_calcinosis1.54835727
21MP0002160_abnormal_reproductive_system1.54518159
22MP0005083_abnormal_biliary_tract1.52995544
23MP0000762_abnormal_tongue_morphology1.52576842
24MP0009250_abnormal_appendicular_skeleto1.51444214
25MP0002736_abnormal_nociception_after1.51415275
26MP0002938_white_spotting1.51064311
27MP0000647_abnormal_sebaceous_gland1.50745302
28MP0005646_abnormal_pituitary_gland1.46862700
29MP0003938_abnormal_ear_development1.44365392
30MP0001293_anophthalmia1.37901400
31MP0004134_abnormal_chest_morphology1.35350787
32MP0001440_abnormal_grooming_behavior1.32022139
33MP0002108_abnormal_muscle_morphology1.25624453
34MP0000428_abnormal_craniofacial_morphol1.23987827
35MP0004145_abnormal_muscle_electrophysio1.23868592
36MP0008877_abnormal_DNA_methylation1.23239593
37MP0000383_abnormal_hair_follicle1.22222159
38MP0002163_abnormal_gland_morphology1.21229038
39MP0003646_muscle_fatigue1.20756430
40MP0002653_abnormal_ependyma_morphology1.20600260
41MP0008995_early_reproductive_senescence1.20154303
42MP0000026_abnormal_inner_ear1.19099607
43MP0005377_hearing/vestibular/ear_phenot1.17566488
44MP0003878_abnormal_ear_physiology1.17566488
45MP0009053_abnormal_anal_canal1.16820712
46MP0001968_abnormal_touch/_nociception1.15349786
47MP0002277_abnormal_respiratory_mucosa1.14680603
48MP0003937_abnormal_limbs/digits/tail_de1.13759503
49MP0000579_abnormal_nail_morphology1.12797758
50MP0003755_abnormal_palate_morphology1.12511991
51MP0000778_abnormal_nervous_system1.08667901
52MP0005503_abnormal_tendon_morphology1.06784556
53MP0005379_endocrine/exocrine_gland_phen1.06590224
54MP0002095_abnormal_skin_pigmentation1.05540837
55MP0005187_abnormal_penis_morphology1.05444252
56MP0000534_abnormal_ureter_morphology1.04996099
57MP0005389_reproductive_system_phenotype1.02334077
58MP0003890_abnormal_embryonic-extraembry0.94546206
59MP0002735_abnormal_chemical_nociception0.93598011
60MP0005171_absent_coat_pigmentation0.93457863
61MP0001958_emphysema0.92944103
62MP0003186_abnormal_redox_activity0.91730825
63MP0002233_abnormal_nose_morphology0.91380040
64MP0000427_abnormal_hair_cycle0.87815777
65MP0001286_abnormal_eye_development0.87620821
66MP0001485_abnormal_pinna_reflex0.87264750
67MP0003942_abnormal_urinary_system0.86358364
68MP0002210_abnormal_sex_determination0.86225067
69MP0001963_abnormal_hearing_physiology0.82358134
70MP0006276_abnormal_autonomic_nervous0.80690753
71MP0000955_abnormal_spinal_cord0.77124261
72MP0003936_abnormal_reproductive_system0.77057621
73MP0003121_genomic_imprinting0.76262871
74MP0002184_abnormal_innervation0.75566804
75MP0002295_abnormal_pulmonary_circulatio0.74613782
76MP0005423_abnormal_somatic_nervous0.74321416
77MP0009745_abnormal_behavioral_response0.73500352
78MP0003567_abnormal_fetal_cardiomyocyte0.73202447
79MP0001986_abnormal_taste_sensitivity0.71971249
80MP0005084_abnormal_gallbladder_morpholo0.71684880
81MP0000462_abnormal_digestive_system0.71305934
82MP0003252_abnormal_bile_duct0.70779675
83MP0000613_abnormal_salivary_gland0.70438026
84MP0001905_abnormal_dopamine_level0.67824472
85MP0003115_abnormal_respiratory_system0.67788063
86MP0000747_muscle_weakness0.67208619
87MP0004742_abnormal_vestibular_system0.64563183
88MP0000653_abnormal_sex_gland0.64086273
89MP0001145_abnormal_male_reproductive0.63376386
90MP0002752_abnormal_somatic_nervous0.62994623
91MP0002067_abnormal_sensory_capabilities0.62196202
92MP0001486_abnormal_startle_reflex0.62132291
93MP0001529_abnormal_vocalization0.61552221
94MP0002733_abnormal_thermal_nociception0.61371039
95MP0002876_abnormal_thyroid_physiology0.61320946
96MP0003283_abnormal_digestive_organ0.61072076
97MP0005551_abnormal_eye_electrophysiolog0.60906874
98MP0002272_abnormal_nervous_system0.59967635
99MP0002697_abnormal_eye_size0.58341199
100MP0002109_abnormal_limb_morphology0.58010780

Predicted human phenotypes

RankGene SetZ-score
1Partial duplication of thumb phalanx (HP:0009944)5.60504932
2Aplasia involving bones of the extremities (HP:0009825)5.09719546
3Aplasia involving bones of the upper limbs (HP:0009823)5.09719546
4Aplasia of the phalanges of the hand (HP:0009802)5.09719546
5Partial duplication of the phalanx of hand (HP:0009999)5.02486641
6Abnormality of the middle phalanges of the toes (HP:0010183)4.67884847
7Esophageal atresia (HP:0002032)4.45779189
8Abnormality of the parietal bone (HP:0002696)4.41918028
9Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.13479756
10Coronal craniosynostosis (HP:0004440)3.98827644
11Stenosis of the external auditory canal (HP:0000402)3.95018206
12Megalencephaly (HP:0001355)3.94367809
13Neonatal short-limb short stature (HP:0008921)3.59318768
14Abnormality of the labia minora (HP:0012880)3.58625002
15Septo-optic dysplasia (HP:0100842)3.42756311
16Gastrointestinal atresia (HP:0002589)3.41726309
17Abnormality of the phalanges of the 2nd finger (HP:0009541)3.30172271
18Broad distal phalanx of finger (HP:0009836)3.21958147
19Abnormality of the 4th metacarpal (HP:0010012)3.21515227
20Duplication of thumb phalanx (HP:0009942)3.19390537
21Abnormality of incisor morphology (HP:0011063)3.15337382
22Nasolacrimal duct obstruction (HP:0000579)3.03042337
23Recurrent corneal erosions (HP:0000495)3.02110549
24Bronchomalacia (HP:0002780)3.00890433
25Down-sloping shoulders (HP:0200021)2.99311109
26Absent septum pellucidum (HP:0001331)2.97252325
27Conical tooth (HP:0000698)2.91683600
28Short 4th metacarpal (HP:0010044)2.85484570
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.85484570
30Chronic otitis media (HP:0000389)2.84226279
31Supernumerary ribs (HP:0005815)2.83165172
32Abnormality of the distal phalanx of the thumb (HP:0009617)2.79601268
33Supernumerary bones of the axial skeleton (HP:0009144)2.71903371
34Alacrima (HP:0000522)2.68095608
35Abnormality of the 2nd finger (HP:0004100)2.65350805
36Abnormality of the lacrimal duct (HP:0011481)2.63022263
37Maternal diabetes (HP:0009800)2.59841968
383-Methylglutaconic aciduria (HP:0003535)2.55103118
39Broad metatarsal (HP:0001783)2.51573136
40Split foot (HP:0001839)2.49512051
41Aqueductal stenosis (HP:0002410)2.48276608
42Abnormality of permanent molar morphology (HP:0011071)2.41260866
43Abnormality of the dental root (HP:0006486)2.41260866
44Taurodontia (HP:0000679)2.41260866
45Thickened helices (HP:0000391)2.41215321
46Abnormality of the septum pellucidum (HP:0007375)2.40374213
47Bifid scrotum (HP:0000048)2.38720133
48Hypoplasia of the radius (HP:0002984)2.35950702
49Reticulocytopenia (HP:0001896)2.35193435
50Abnormality of alanine metabolism (HP:0010916)2.34064702
51Hyperalaninemia (HP:0003348)2.34064702
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34064702
53Visceral angiomatosis (HP:0100761)2.31544396
54Humeroradial synostosis (HP:0003041)2.29107722
55Synostosis involving the elbow (HP:0003938)2.29107722
56Abnormality of the incisor (HP:0000676)2.28668015
57Respiratory distress (HP:0002098)2.27478325
58Synostosis of carpal bones (HP:0005048)2.27457986
59Symphalangism affecting the phalanges of the hand (HP:0009773)2.26626039
60Abnormality of cells of the erythroid lineage (HP:0012130)2.26181342
61Mixed hearing impairment (HP:0000410)2.25961885
62Sleep apnea (HP:0010535)2.25636149
63Hypoplasia of the ulna (HP:0003022)2.25522230
64Abnormality of molar morphology (HP:0011070)2.25305337
65Abnormality of molar (HP:0011077)2.25305337
66Preaxial foot polydactyly (HP:0001841)2.23266068
67Vertebral fusion (HP:0002948)2.21964976
68Abnormality of the nasolacrimal system (HP:0000614)2.20861915
69Abnormal number of erythroid precursors (HP:0012131)2.20637642
70Abnormality of the dental pulp (HP:0006479)2.18104684
71Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17215294
72Absent radius (HP:0003974)2.16228092
73Cutaneous finger syndactyly (HP:0010554)2.13792518
74Absent forearm bone (HP:0003953)2.12174031
75Aplasia involving forearm bones (HP:0009822)2.12174031
76True hermaphroditism (HP:0010459)2.10122184
77Acute necrotizing encephalopathy (HP:0006965)2.09363947
78Macrocytic anemia (HP:0001972)2.08742429
79Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08295543
80Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08295543
81Neoplasm of the heart (HP:0100544)2.06051487
82Hemangiomatosis (HP:0007461)2.04736432
83Rib fusion (HP:0000902)2.04484275
84Decreased lacrimation (HP:0000633)2.03162534
85Hemivertebrae (HP:0002937)2.02326205
86Constricted visual fields (HP:0001133)1.92895736
87Short phalanx of the thumb (HP:0009660)1.92778618
88Increased serum pyruvate (HP:0003542)1.91951488
89Vaginal atresia (HP:0000148)1.91253683
90Broad hallux (HP:0010055)1.88798043
91Hamartoma (HP:0010566)1.84980795
92Aplasia/Hypoplasia of the ulna (HP:0006495)1.84511536
93Short middle phalanx of finger (HP:0005819)1.83906793
94Abnormality of the salivary glands (HP:0010286)1.83380132
9511 pairs of ribs (HP:0000878)1.83208374
96Birth length less than 3rd percentile (HP:0003561)1.82865588
97Xerostomia (HP:0000217)1.82691190
98Abnormal mitochondria in muscle tissue (HP:0008316)1.82606683
99Genital tract atresia (HP:0001827)1.81408666
1002-3 toe syndactyly (HP:0004691)1.80624061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR26.22872346
2PINK14.97026355
3WNK44.47746552
4STK393.02659728
5CASK2.55037885
6MAP2K32.32762087
7NME22.13727117
8PNCK2.04833057
9FGFR12.02840580
10NME11.88512887
11NTRK21.78668741
12BUB11.77691504
13MAP3K61.72882286
14FGFR31.70829413
15NUAK11.69086505
16DYRK21.65442740
17OXSR11.62843379
18TLK11.60665098
19ADRBK21.43157390
20WNK31.36265323
21PHKG11.35823895
22PHKG21.35823895
23LATS11.35000704
24STK38L1.32484014
25PIK3CA1.31353675
26PDK21.29555065
27WNK11.27542481
28ADRBK11.18450856
29STK161.18398607
30MAP2K71.14877668
31GRK71.11089718
32ACVR1B1.10795929
33GRK11.08472682
34ABL21.06826560
35CDK191.03876532
36TIE11.03700796
37EPHB21.02120578
38HIPK21.01602992
39EPHA41.00901983
40MAP2K60.97913286
41DYRK30.96136949
42OBSCN0.94620862
43FRK0.93678219
44BMPR1B0.93163349
45MINK10.90826783
46MAP2K40.87488396
47BCKDK0.85813573
48AURKA0.78526362
49VRK20.76075769
50MAP4K20.73812685
51DYRK1B0.69775783
52WEE10.68761393
53MAP3K30.66636790
54INSRR0.62062033
55TYRO30.60910533
56PRKCG0.58611386
57MAP3K110.56820770
58TESK20.53132488
59ZAK0.52994234
60CSNK1G30.51351508
61STK380.49801259
62MAPK130.48225149
63PLK10.47614898
64PLK20.47035174
65CSNK1G20.45784444
66PRKACA0.43975195
67PIM10.43361402
68TNIK0.42431464
69CSNK2A10.41996846
70CDK30.41039901
71VRK10.40201820
72PRKCE0.40105397
73TAOK30.39732357
74CSNK1G10.39231433
75CSNK1E0.39118325
76AKT20.37977022
77CSNK2A20.37709235
78IKBKB0.37507647
79MAP3K50.37208902
80CAMK10.35368669
81MAP3K70.35326906
82CSNK1A1L0.34824567
83UHMK10.34624316
84CAMK1G0.33513523
85CDK50.31074452
86MST40.31039416
87RPS6KA50.29881009
88MAP3K40.28621255
89SGK4940.28591741
90SGK2230.28591741
91GRK50.28327865
92RPS6KA60.27578080
93CDK90.26546266
94ERBB20.26387509
95PASK0.24908411
96PRKD30.24769042
97FGR0.24658109
98SGK10.24565537
99CAMK2A0.24175109
100JAK30.23535156

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.00258449
2Oxidative phosphorylation_Homo sapiens_hsa001904.55114747
3Parkinsons disease_Homo sapiens_hsa050123.81245318
4Cardiac muscle contraction_Homo sapiens_hsa042602.90209567
5Huntingtons disease_Homo sapiens_hsa050162.75656472
6Alzheimers disease_Homo sapiens_hsa050102.65771814
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.44615995
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.41158232
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29835440
10One carbon pool by folate_Homo sapiens_hsa006702.01120908
11Proteasome_Homo sapiens_hsa030501.87239719
12Asthma_Homo sapiens_hsa053101.75224343
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68098892
14Homologous recombination_Homo sapiens_hsa034401.64927057
15Protein export_Homo sapiens_hsa030601.60272280
16Nicotine addiction_Homo sapiens_hsa050331.55368486
17RNA polymerase_Homo sapiens_hsa030201.50942811
18Sulfur relay system_Homo sapiens_hsa041221.48468145
19Olfactory transduction_Homo sapiens_hsa047401.46454184
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45825208
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37639792
22Spliceosome_Homo sapiens_hsa030401.36350019
23Fanconi anemia pathway_Homo sapiens_hsa034601.34229488
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.33874387
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29403527
26Nitrogen metabolism_Homo sapiens_hsa009101.26160544
27Pyrimidine metabolism_Homo sapiens_hsa002401.23300966
28Basal cell carcinoma_Homo sapiens_hsa052171.21162286
29Folate biosynthesis_Homo sapiens_hsa007901.20945858
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20132312
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.20007018
32DNA replication_Homo sapiens_hsa030301.15184611
33Hedgehog signaling pathway_Homo sapiens_hsa043401.14577612
34Collecting duct acid secretion_Homo sapiens_hsa049661.11503037
35RNA degradation_Homo sapiens_hsa030181.08606600
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08062330
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07357561
38Nucleotide excision repair_Homo sapiens_hsa034201.01269701
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97859558
40Intestinal immune network for IgA production_Homo sapiens_hsa046720.97180968
41Cyanoamino acid metabolism_Homo sapiens_hsa004600.96080927
42Butanoate metabolism_Homo sapiens_hsa006500.95153140
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94530571
44Graft-versus-host disease_Homo sapiens_hsa053320.91387462
45Morphine addiction_Homo sapiens_hsa050320.90447107
46Type I diabetes mellitus_Homo sapiens_hsa049400.90301345
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88297914
48Allograft rejection_Homo sapiens_hsa053300.87781650
49Regulation of autophagy_Homo sapiens_hsa041400.87766763
50Autoimmune thyroid disease_Homo sapiens_hsa053200.86936613
51RNA transport_Homo sapiens_hsa030130.84773176
52Taste transduction_Homo sapiens_hsa047420.84310722
53Purine metabolism_Homo sapiens_hsa002300.83365856
54Basal transcription factors_Homo sapiens_hsa030220.81101942
55Arginine biosynthesis_Homo sapiens_hsa002200.80474518
56Serotonergic synapse_Homo sapiens_hsa047260.79583518
57GABAergic synapse_Homo sapiens_hsa047270.78575929
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75622110
59Glutathione metabolism_Homo sapiens_hsa004800.74745519
60Metabolic pathways_Homo sapiens_hsa011000.72450563
61Selenocompound metabolism_Homo sapiens_hsa004500.66283495
62Peroxisome_Homo sapiens_hsa041460.65864144
63Retinol metabolism_Homo sapiens_hsa008300.64904503
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62384349
65Arginine and proline metabolism_Homo sapiens_hsa003300.61924904
66Linoleic acid metabolism_Homo sapiens_hsa005910.61084044
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60956455
68Systemic lupus erythematosus_Homo sapiens_hsa053220.59850410
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59307676
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.59201689
71Rheumatoid arthritis_Homo sapiens_hsa053230.55935341
72Chemical carcinogenesis_Homo sapiens_hsa052040.52834295
73Phototransduction_Homo sapiens_hsa047440.51676262
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51042814
75Fat digestion and absorption_Homo sapiens_hsa049750.49654381
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48947144
77Propanoate metabolism_Homo sapiens_hsa006400.47129732
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46529737
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44964259
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44055832
81Sulfur metabolism_Homo sapiens_hsa009200.39906881
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39418155
83Circadian entrainment_Homo sapiens_hsa047130.39138213
84Glycerolipid metabolism_Homo sapiens_hsa005610.36962333
85Ether lipid metabolism_Homo sapiens_hsa005650.36121634
86Mineral absorption_Homo sapiens_hsa049780.34907897
87Arachidonic acid metabolism_Homo sapiens_hsa005900.33496855
88Mismatch repair_Homo sapiens_hsa034300.33495811
89p53 signaling pathway_Homo sapiens_hsa041150.33403950
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30863350
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30860892
92Glutamatergic synapse_Homo sapiens_hsa047240.30176058
93Alcoholism_Homo sapiens_hsa050340.29959131
94Tryptophan metabolism_Homo sapiens_hsa003800.29818401
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.25941827
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23753218
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23741986
98Insulin secretion_Homo sapiens_hsa049110.22852576
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.18292908
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.18115937

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