ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	7.41190850
2	ribosomal small subunit biogenesis (GO:0042274)	6.71138569
3	ATP synthesis coupled proton transport (GO:0015986)	6.27903425
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.27903425
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.20524267
6	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	6.05979603
7	viral transcription (GO:0019083)	5.86249018
8	translational termination (GO:0006415)	5.71578232
9	maturation of SSU-rRNA (GO:0030490)	5.62218744
10	protein complex biogenesis (GO:0070271)	5.52023304
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.50148589
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.50148589
13	NADH dehydrogenase complex assembly (GO:0010257)	5.50148589
14	GTP biosynthetic process (GO:0006183)	5.48106937
15	respiratory electron transport chain (GO:0022904)	5.39346705
16	electron transport chain (GO:0022900)	5.35896434
17	protein neddylation (GO:0045116)	5.22194815
18	mitochondrial respiratory chain complex assembly (GO:0033108)	5.21872940
19	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.19268192
20	cotranslational protein targeting to membrane (GO:0006613)	5.11870352
21	ribosomal small subunit assembly (GO:0000028)	5.06738797
22	translational elongation (GO:0006414)	5.04637659
23	protein targeting to ER (GO:0045047)	5.03898781
24	proteasome assembly (GO:0043248)	4.93301174
25	UTP biosynthetic process (GO:0006228)	4.85351918
26	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.77907746
27	protein localization to endoplasmic reticulum (GO:0070972)	4.73534429
28	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.50021062
29	UTP metabolic process (GO:0046051)	4.48697380
30	cellular protein complex disassembly (GO:0043624)	4.42435260
31	guanosine-containing compound biosynthetic process (GO:1901070)	4.33617937
32	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.28192208
33	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.25971468
34	viral life cycle (GO:0019058)	4.25327063
35	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.24619225
36	ribosomal large subunit biogenesis (GO:0042273)	4.24249876
37	purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.20192726
38	CTP metabolic process (GO:0046036)	4.19818889
39	CTP biosynthetic process (GO:0006241)	4.19818889
40	protein-cofactor linkage (GO:0018065)	4.14760951
41	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.11211767
42	translation (GO:0006412)	4.10646841
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.98314691
44	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.98314691
45	regulation of mitochondrial translation (GO:0070129)	3.96027977
46	respiratory chain complex IV assembly (GO:0008535)	3.94789601
47	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.92368881
48	translational initiation (GO:0006413)	3.92011725
49	ATP biosynthetic process (GO:0006754)	3.90324399
50	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.88957374
51	water-soluble vitamin biosynthetic process (GO:0042364)	3.87873187
52	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.87527499
53	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.81622933
54	cellular component biogenesis (GO:0044085)	3.76833198
55	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.72160658
56	termination of RNA polymerase III transcription (GO:0006386)	3.72160658
57	rRNA modification (GO:0000154)	3.72009755
58	protein deneddylation (GO:0000338)	3.69487240
59	protein complex disassembly (GO:0043241)	3.63207627
60	peptidyl-histidine modification (GO:0018202)	3.62600491
61	cytochrome complex assembly (GO:0017004)	3.60181514
62	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.60073746
63	pyrimidine nucleotide catabolic process (GO:0006244)	3.59563429
64	hydrogen ion transmembrane transport (GO:1902600)	3.57426271
65	protein targeting to mitochondrion (GO:0006626)	3.55265913
66	macromolecular complex disassembly (GO:0032984)	3.48003391
67	ribonucleoprotein complex biogenesis (GO:0022613)	3.36947753
68	nucleoside triphosphate biosynthetic process (GO:0009142)	3.34371899
69	cullin deneddylation (GO:0010388)	3.32422770
70	inner mitochondrial membrane organization (GO:0007007)	3.30265639
71	protein localization to mitochondrion (GO:0070585)	3.25438280
72	establishment of protein localization to mitochondrion (GO:0072655)	3.24590304
73	protein targeting to membrane (GO:0006612)	3.23313566
74	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.23156286
75	kinetochore assembly (GO:0051382)	3.22875200
76	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.22235391
77	pseudouridine synthesis (GO:0001522)	3.20798512
78	DNA deamination (GO:0045006)	3.20022923
79	iron-sulfur cluster assembly (GO:0016226)	3.20015466
80	metallo-sulfur cluster assembly (GO:0031163)	3.20015466
81	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.19200560
82	spliceosomal snRNP assembly (GO:0000387)	3.10718074
83	proton transport (GO:0015992)	3.10229519
84	hydrogen transport (GO:0006818)	3.05190358
85	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.05103028
86	nucleoside diphosphate phosphorylation (GO:0006165)	3.04067290
87	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.02581034
88	rRNA processing (GO:0006364)	3.01572262
89	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.97846405
90	DNA damage response, detection of DNA damage (GO:0042769)	2.93833879
91	tRNA processing (GO:0008033)	2.92072164
92	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.90807333
93	kinetochore organization (GO:0051383)	2.89501437
94	mRNA catabolic process (GO:0006402)	2.87755090
95	rRNA metabolic process (GO:0016072)	2.86435356
96	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.85663691
97	purine nucleotide salvage (GO:0032261)	2.85158439
98	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.84489088
99	ubiquinone biosynthetic process (GO:0006744)	2.82673118
100	purine nucleoside biosynthetic process (GO:0042451)	2.76716648

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.93516105
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.85039851
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.38222293
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.33247549
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.04719167
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.76071439
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.75957558
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.50700038
9	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.36224358
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.35305939
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.31525040
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.25880762
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.24609400
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.86790157
15	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.76523021
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.59945072
17	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.40702247
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.39210636
19	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.38934592
20	EZH2_22144423_ChIP-Seq_EOC_Human	2.33414774
21	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.30040882
22	FOXP3_21729870_ChIP-Seq_TREG_Human	2.27054521
23	XRN2_22483619_ChIP-Seq_HELA_Human	2.21469085
24	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.12646994
25	DCP1A_22483619_ChIP-Seq_HELA_Human	2.09569981
26	GABP_19822575_ChIP-Seq_HepG2_Human	2.07811244
27	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.03866295
28	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.01400025
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.01266798
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.98826983
31	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.94554930
32	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.81173267
33	TTF2_22483619_ChIP-Seq_HELA_Human	1.70640242
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.68567426
35	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.68216855
36	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.67261928
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.64950491
38	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.58207824
39	ZNF274_21170338_ChIP-Seq_K562_Hela	1.58202804
40	ZNF263_19887448_ChIP-Seq_K562_Human	1.57790003
41	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.57766356
42	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.50486472
43	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.46271563
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.42394623
45	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.39040280
46	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.34520463
47	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.28462131
48	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.25465830
49	VDR_22108803_ChIP-Seq_LS180_Human	1.22097917
50	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.21691501
51	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.19826237
52	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.16265609
53	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.16035046
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.14891465
55	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.12931584
56	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.12084733
57	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.08862827
58	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.04248738
59	KDM5A_27292631_Chip-Seq_BREAST_Human	1.03855445
60	IRF1_19129219_ChIP-ChIP_H3396_Human	1.03632842
61	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.03067887
62	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.01977668
63	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01946613
64	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.98421888
65	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.97667794
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97599508
67	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.96607702
68	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.93711489
69	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.93468833
70	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.91488280
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.90463061
72	AR_20517297_ChIP-Seq_VCAP_Human	0.90430689
73	TAF2_19829295_ChIP-Seq_ESCs_Human	0.89663893
74	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.89514842
75	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.89021039
76	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.88630270
77	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.88002844
78	CIITA_25753668_ChIP-Seq_RAJI_Human	0.87689408
79	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.87551085
80	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.86996622
81	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.86827907
82	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.86580690
83	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.86486561
84	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.85824933
85	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.84599673
86	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.84426063
87	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.84345741
88	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.84345741
89	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.84345741
90	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.83878373
91	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.82316014
92	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.81571119
93	EWS_26573619_Chip-Seq_HEK293_Human	0.79977130
94	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.79815936
95	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.79502207
96	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.78731301
97	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.76983583
98	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.74960946
99	BCL6_27268052_Chip-Seq_Bcells_Human	0.74706274
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.74228048

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.05802362
2	MP0006292_abnormal_olfactory_placode	4.81214060
3	MP0004147_increased_porphyrin_level	4.23185028
4	MP0008789_abnormal_olfactory_epithelium	3.47129967
5	MP0005499_abnormal_olfactory_system	3.05471421
6	MP0005394_taste/olfaction_phenotype	3.05471421
7	MP0005671_abnormal_response_to	2.88377620
8	MP0002234_abnormal_pharynx_morphology	2.57293617
9	MP0002102_abnormal_ear_morphology	2.47631955
10	MP0001529_abnormal_vocalization	2.27452781
11	MP0000372_irregular_coat_pigmentation	2.17427983
12	MP0000049_abnormal_middle_ear	2.16156880
13	MP0008058_abnormal_DNA_repair	1.92695410
14	MP0005646_abnormal_pituitary_gland	1.87940979
15	MP0004145_abnormal_muscle_electrophysio	1.80096236
16	MP0008877_abnormal_DNA_methylation	1.71589835
17	MP0002277_abnormal_respiratory_mucosa	1.70763352
18	MP0005551_abnormal_eye_electrophysiolog	1.69846340
19	MP0003786_premature_aging	1.67210439
20	MP0003880_abnormal_central_pattern	1.66666458
21	MP0005377_hearing/vestibular/ear_phenot	1.64898721
22	MP0003878_abnormal_ear_physiology	1.64898721
23	MP0001905_abnormal_dopamine_level	1.63861753
24	MP0002090_abnormal_vision	1.62353174
25	MP0002938_white_spotting	1.62145338
26	MP0006036_abnormal_mitochondrial_physio	1.59000310
27	MP0001188_hyperpigmentation	1.58572397
28	MP0002638_abnormal_pupillary_reflex	1.56667596
29	MP0001293_anophthalmia	1.45322555
30	MP0003693_abnormal_embryo_hatching	1.39932958
31	MP0002736_abnormal_nociception_after	1.39404961
32	MP0010030_abnormal_orbit_morphology	1.39330349
33	MP0003011_delayed_dark_adaptation	1.38708824
34	MP0004142_abnormal_muscle_tone	1.35988734
35	MP0002163_abnormal_gland_morphology	1.32426438
36	MP0002653_abnormal_ependyma_morphology	1.31646321
37	MP0008932_abnormal_embryonic_tissue	1.31041100
38	MP0006072_abnormal_retinal_apoptosis	1.30753553
39	MP0002837_dystrophic_cardiac_calcinosis	1.30214815
40	MP0003866_abnormal_defecation	1.29757863
41	MP0008995_early_reproductive_senescence	1.28573828
42	MP0003186_abnormal_redox_activity	1.26675579
43	MP0002160_abnormal_reproductive_system	1.23528964
44	MP0005645_abnormal_hypothalamus_physiol	1.22388950
45	MP0000566_synostosis	1.18325172
46	MP0003879_abnormal_hair_cell	1.18217185
47	MP0009053_abnormal_anal_canal	1.17697169
48	MP0003763_abnormal_thymus_physiology	1.14853742
49	MP0003567_abnormal_fetal_cardiomyocyte	1.14465294
50	MP0005084_abnormal_gallbladder_morpholo	1.12205362
51	MP0008875_abnormal_xenobiotic_pharmacok	1.10900988
52	MP0001984_abnormal_olfaction	1.10527012
53	MP0005253_abnormal_eye_physiology	1.08246041
54	MP0003111_abnormal_nucleus_morphology	1.07452430
55	MP0001270_distended_abdomen	1.06331236
56	MP0003195_calcinosis	1.06022262
57	MP0000026_abnormal_inner_ear	1.04164506
58	MP0001485_abnormal_pinna_reflex	1.00109171
59	MP0005195_abnormal_posterior_eye	0.99278067
60	MP0001986_abnormal_taste_sensitivity	0.97190361
61	MP0003315_abnormal_perineum_morphology	0.96747053
62	MP0002233_abnormal_nose_morphology	0.95498835
63	MP0002184_abnormal_innervation	0.95443076
64	MP0002095_abnormal_skin_pigmentation	0.94476845
65	MP0004858_abnormal_nervous_system	0.93930315
66	MP0001764_abnormal_homeostasis	0.93355523
67	MP0005075_abnormal_melanosome_morpholog	0.93114613
68	MP0001486_abnormal_startle_reflex	0.93079759
69	MP0005360_urolithiasis	0.92964320
70	MP0003938_abnormal_ear_development	0.91705638
71	MP0001919_abnormal_reproductive_system	0.90044506
72	MP0005379_endocrine/exocrine_gland_phen	0.89587986
73	MP0001968_abnormal_touch/_nociception	0.89313983
74	MP0010094_abnormal_chromosome_stability	0.88488985
75	MP0000678_abnormal_parathyroid_gland	0.88310457
76	MP0001963_abnormal_hearing_physiology	0.86681302
77	MP0002752_abnormal_somatic_nervous	0.86021143
78	MP0002876_abnormal_thyroid_physiology	0.83557751
79	MP0002210_abnormal_sex_determination	0.83285853
80	MP0002177_abnormal_outer_ear	0.82077785
81	MP0005389_reproductive_system_phenotype	0.81391025
82	MP0000631_abnormal_neuroendocrine_gland	0.78060224
83	MP0001346_abnormal_lacrimal_gland	0.76904326
84	MP0003137_abnormal_impulse_conducting	0.75574841
85	MP0004885_abnormal_endolymph	0.74156241
86	MP0009745_abnormal_behavioral_response	0.72668619
87	MP0003119_abnormal_digestive_system	0.71675349
88	MP0003718_maternal_effect	0.71145591
89	MP0005332_abnormal_amino_acid	0.66228927
90	MP0000647_abnormal_sebaceous_gland	0.65478187
91	MP0005391_vision/eye_phenotype	0.65164090
92	MP0003122_maternal_imprinting	0.64271236
93	MP0003755_abnormal_palate_morphology	0.63108710
94	MP0006035_abnormal_mitochondrial_morpho	0.62494171
95	MP0005647_abnormal_sex_gland	0.62347179
96	MP0002572_abnormal_emotion/affect_behav	0.61428464
97	MP0005365_abnormal_bile_salt	0.61293422
98	MP0008872_abnormal_physiological_respon	0.61012961
99	MP0000653_abnormal_sex_gland	0.59875737
100	MP0003646_muscle_fatigue	0.59861982

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.65497103
2	Abnormal mitochondria in muscle tissue (HP:0008316)	5.46214434
3	Mitochondrial inheritance (HP:0001427)	4.97225541
4	Acute encephalopathy (HP:0006846)	4.87111122
5	Progressive macrocephaly (HP:0004481)	4.58525587
6	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.47591582
7	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.47591582
8	Increased CSF lactate (HP:0002490)	4.45817499
9	Renal Fanconi syndrome (HP:0001994)	4.43432758
10	Hepatocellular necrosis (HP:0001404)	4.00026528
11	Increased intramyocellular lipid droplets (HP:0012240)	3.85372166
12	Increased hepatocellular lipid droplets (HP:0006565)	3.82668558
13	Cerebral edema (HP:0002181)	3.61017268
14	Hepatic necrosis (HP:0002605)	3.53792960
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.46253100
16	Macrocytic anemia (HP:0001972)	3.42091644
17	Testicular atrophy (HP:0000029)	3.25937976
18	Lipid accumulation in hepatocytes (HP:0006561)	3.22409030
19	3-Methylglutaconic aciduria (HP:0003535)	3.21670071
20	Lactic acidosis (HP:0003128)	3.21232529
21	Increased muscle lipid content (HP:0009058)	3.10413148
22	Increased serum lactate (HP:0002151)	3.09881174
23	Respiratory failure (HP:0002878)	2.95480557
24	Abnormal number of erythroid precursors (HP:0012131)	2.89188764
25	Abnormality of cells of the erythroid lineage (HP:0012130)	2.88351007
26	Generalized aminoaciduria (HP:0002909)	2.87940275
27	Aplastic anemia (HP:0001915)	2.66728095
28	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.65887027
29	Exercise intolerance (HP:0003546)	2.65159383
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.63249656
31	Abnormality of renal resorption (HP:0011038)	2.57657090
32	Leukodystrophy (HP:0002415)	2.52551822
33	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.51714460
34	Abnormality of alanine metabolism (HP:0010916)	2.51714460
35	Hyperalaninemia (HP:0003348)	2.51714460
36	Abnormality of midbrain morphology (HP:0002418)	2.49848058
37	Molar tooth sign on MRI (HP:0002419)	2.49848058
38	Abnormality of urine glucose concentration (HP:0011016)	2.46784178
39	Glycosuria (HP:0003076)	2.46784178
40	Reticulocytopenia (HP:0001896)	2.42803443
41	Renal cortical cysts (HP:0000803)	2.42632701
42	Exertional dyspnea (HP:0002875)	2.40917982
43	Asplenia (HP:0001746)	2.39176682
44	Optic disc pallor (HP:0000543)	2.37952220
45	Lethargy (HP:0001254)	2.33982473
46	Pancytopenia (HP:0001876)	2.29113252
47	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.27650872
48	Dyschromatopsia (HP:0007641)	2.20438888
49	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.17589066
50	Autoimmune hemolytic anemia (HP:0001890)	2.17523381
51	Hypoplastic pelvis (HP:0008839)	2.13734297
52	Hyperglycinemia (HP:0002154)	2.12207057
53	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.11163500
54	Autoimmune thrombocytopenia (HP:0001973)	2.08655581
55	Gout (HP:0001997)	2.07723511
56	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.06064746
57	Microretrognathia (HP:0000308)	2.05644749
58	Abnormal drinking behavior (HP:0030082)	2.05172403
59	Polydipsia (HP:0001959)	2.05172403
60	Abolished electroretinogram (ERG) (HP:0000550)	2.03470472
61	Septo-optic dysplasia (HP:0100842)	2.01917699
62	Increased serum pyruvate (HP:0003542)	2.01824460
63	Visual hallucinations (HP:0002367)	2.01520003
64	Pallor (HP:0000980)	1.99337437
65	Abnormality of the renal cortex (HP:0011035)	1.98870879
66	Methylmalonic acidemia (HP:0002912)	1.95454831
67	Medial flaring of the eyebrow (HP:0010747)	1.94384572
68	CNS demyelination (HP:0007305)	1.93038844
69	Triphalangeal thumb (HP:0001199)	1.92396437
70	Hyperphosphaturia (HP:0003109)	1.92193177
71	Constricted visual fields (HP:0001133)	1.91997044
72	Male infertility (HP:0003251)	1.91636514
73	Congenital stationary night blindness (HP:0007642)	1.88533620
74	Pancreatic cysts (HP:0001737)	1.88258631
75	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.85527978
76	Microvesicular hepatic steatosis (HP:0001414)	1.85151234
77	X-linked dominant inheritance (HP:0001423)	1.84540627
78	Opisthotonus (HP:0002179)	1.82973257
79	Spastic paraparesis (HP:0002313)	1.82536891
80	Myokymia (HP:0002411)	1.81805629
81	Parakeratosis (HP:0001036)	1.80185266
82	Polyuria (HP:0000103)	1.77639213
83	Type 2 muscle fiber atrophy (HP:0003554)	1.76325833
84	Hypoplastic left heart (HP:0004383)	1.75218321
85	Chronic bronchitis (HP:0004469)	1.72659458
86	Renal dysplasia (HP:0000110)	1.71802754
87	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.71227945
88	Methylmalonic aciduria (HP:0012120)	1.70347400
89	Absent thumb (HP:0009777)	1.69171056
90	Hypophosphatemic rickets (HP:0004912)	1.68415082
91	Forearm undergrowth (HP:0009821)	1.67299209
92	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.67134212
93	Severe combined immunodeficiency (HP:0004430)	1.66723849
94	Failure to thrive in infancy (HP:0001531)	1.66426410
95	Abnormal respiratory motile cilium physiology (HP:0012261)	1.64764509
96	Muscle fiber atrophy (HP:0100295)	1.64187984
97	Respiratory difficulties (HP:0002880)	1.63702209
98	Ragged-red muscle fibers (HP:0003200)	1.63496417
99	Abnormality of placental membranes (HP:0011409)	1.62652859
100	Amniotic constriction ring (HP:0009775)	1.62652859

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	4.84787913
2	NME2	4.31464724
3	STK16	3.28142834
4	TXK	2.72980485
5	LIMK1	2.45316457
6	BUB1	2.45050324
7	MAP4K1	2.31726683
8	TIE1	2.23411967
9	KDR	2.14871413
10	VRK2	2.03132432
11	ADRBK2	1.97415770
12	GRK1	1.95285757
13	TRIM28	1.95032496
14	BCKDK	1.85013444
15	NME1	1.83040556
16	TESK1	1.70719586
17	NEK1	1.65584154
18	MAP4K2	1.58524740
19	LRRK2	1.47439082
20	ARAF	1.45140993
21	TEC	1.37586323
22	SRPK1	1.37536315
23	PLK4	1.37315139
24	MAP3K9	1.37029505
25	CDK8	1.22750369
26	MAPKAPK3	1.18118634
27	PDK2	1.13845669
28	PASK	1.12883131
29	EPHA4	1.10072719
30	MAP2K7	1.09644490
31	WNK3	1.08510666
32	BCR	1.06377333
33	DYRK2	1.04581865
34	CSNK1G3	1.04392047
35	CCNB1	1.03830359
36	CSNK1G2	1.02821048
37	MAP3K11	1.01103080
38	VRK1	1.01074125
39	PIK3CA	0.96504884
40	WNK4	0.93393190
41	ITK	0.90089578
42	TLK1	0.88804558
43	MAP3K4	0.87312957
44	SCYL2	0.85387189
45	PIM2	0.84585482
46	ABL2	0.83760641
47	TSSK6	0.82880412
48	DMPK	0.81949629
49	BRAF	0.81019275
50	ZAK	0.80142380
51	INSRR	0.79659485
52	RPS6KA5	0.79602223
53	MUSK	0.78273152
54	CSNK1G1	0.75379947
55	CSNK2A1	0.73531311
56	CSNK1A1L	0.70646277
57	CAMKK2	0.70096670
58	MST4	0.69759116
59	AURKA	0.69371370
60	EIF2AK1	0.68721856
61	BMPR1B	0.68562995
62	PLK1	0.68163160
63	CDK18	0.67691933
64	CSNK2A2	0.67639071
65	CDK15	0.67514875
66	CDC7	0.67257986
67	BTK	0.64640700
68	PRKCG	0.64609677
69	CDK14	0.62805638
70	CASK	0.62207113
71	CDK11A	0.61446427
72	OBSCN	0.61095475
73	IKBKB	0.60030637
74	AURKB	0.58966575
75	MAPK13	0.58543799
76	CAMK2A	0.55362836
77	GRK6	0.53217032
78	ADRBK1	0.51826151
79	PINK1	0.51178649
80	CDK19	0.49353766
81	PRKCI	0.49244361
82	RPS6KA4	0.49192638
83	FES	0.48151280
84	CAMK1	0.47345828
85	CSNK1A1	0.47237420
86	TNK2	0.47183988
87	PRKACA	0.46683898
88	PRKCQ	0.46121113
89	TAOK3	0.46077642
90	CAMK2G	0.45669850
91	BRSK1	0.45634470
92	ATR	0.43282717
93	MAP3K5	0.41920024
94	ATM	0.41562847
95	IGF1R	0.41530695
96	NUAK1	0.40527625
97	PBK	0.39618033
98	CAMK2D	0.39510030
99	STK39	0.39287150
100	NTRK2	0.37901287

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.63759589
2	Oxidative phosphorylation_Homo sapiens_hsa00190	5.13398577
3	Parkinsons disease_Homo sapiens_hsa05012	4.40069460
4	Proteasome_Homo sapiens_hsa03050	3.53982465
5	Huntingtons disease_Homo sapiens_hsa05016	3.12986279
6	RNA polymerase_Homo sapiens_hsa03020	3.01067813
7	Alzheimers disease_Homo sapiens_hsa05010	3.00867080
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.65810701
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.62005457
10	Protein export_Homo sapiens_hsa03060	2.57134559
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.23625148
12	Homologous recombination_Homo sapiens_hsa03440	2.23463416
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10110737
14	Spliceosome_Homo sapiens_hsa03040	2.08174784
15	Pyrimidine metabolism_Homo sapiens_hsa00240	2.01869193
16	DNA replication_Homo sapiens_hsa03030	1.92676789
17	Primary immunodeficiency_Homo sapiens_hsa05340	1.88507336
18	Mismatch repair_Homo sapiens_hsa03430	1.65565486
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.63866601
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.59045059
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.57016860
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.50581132
23	One carbon pool by folate_Homo sapiens_hsa00670	1.44729993
24	Phototransduction_Homo sapiens_hsa04744	1.38435073
25	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.34091131
26	Basal transcription factors_Homo sapiens_hsa03022	1.33992955
27	Purine metabolism_Homo sapiens_hsa00230	1.26243890
28	Steroid biosynthesis_Homo sapiens_hsa00100	1.19381115
29	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.07445488
30	RNA transport_Homo sapiens_hsa03013	1.04028220
31	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.00172915
32	RNA degradation_Homo sapiens_hsa03018	0.99589466
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.99190202
34	Base excision repair_Homo sapiens_hsa03410	0.93746084
35	Nitrogen metabolism_Homo sapiens_hsa00910	0.89516413
36	Metabolic pathways_Homo sapiens_hsa01100	0.89441076
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.88970589
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.86271920
39	Folate biosynthesis_Homo sapiens_hsa00790	0.85441190
40	Peroxisome_Homo sapiens_hsa04146	0.82430174
41	Collecting duct acid secretion_Homo sapiens_hsa04966	0.80366803
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.78042783
43	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.74023524
44	Sulfur relay system_Homo sapiens_hsa04122	0.72865588
45	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71449830
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.69085124
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.68765031
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.65689004
49	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62119475
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61446869
51	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.60510707
52	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.56396144
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.56230381
54	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.56085687
55	Propanoate metabolism_Homo sapiens_hsa00640	0.53551409
56	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.52707153
57	Retinol metabolism_Homo sapiens_hsa00830	0.51907148
58	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.51342900
59	Linoleic acid metabolism_Homo sapiens_hsa00591	0.49437780
60	Pyruvate metabolism_Homo sapiens_hsa00620	0.45912717
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45003409
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.43154739
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.40617876
64	Olfactory transduction_Homo sapiens_hsa04740	0.39607392
65	Non-homologous end-joining_Homo sapiens_hsa03450	0.38741281
66	Antigen processing and presentation_Homo sapiens_hsa04612	0.37260924
67	mRNA surveillance pathway_Homo sapiens_hsa03015	0.36560746
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.35190028
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.33971484
70	Glutathione metabolism_Homo sapiens_hsa00480	0.32786096
71	Butanoate metabolism_Homo sapiens_hsa00650	0.31772837
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.31122424
73	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.27871150
74	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.26613437
75	Tyrosine metabolism_Homo sapiens_hsa00350	0.25324356
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.23587001
77	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.23578187
78	Tryptophan metabolism_Homo sapiens_hsa00380	0.23302539
79	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.23237655
80	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.23068265
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.20363743
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.19735598
83	Renin-angiotensin system_Homo sapiens_hsa04614	0.18148263
84	Sulfur metabolism_Homo sapiens_hsa00920	0.17207122
85	Nicotine addiction_Homo sapiens_hsa05033	0.16586571
86	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.15688642
87	Ether lipid metabolism_Homo sapiens_hsa00565	0.15521246
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.15460784
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.15056626
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.14465850
91	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.14028073
92	Fatty acid elongation_Homo sapiens_hsa00062	0.13652789
93	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.12553547
94	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.11941753
95	Phenylalanine metabolism_Homo sapiens_hsa00360	0.11816133
96	Cell cycle_Homo sapiens_hsa04110	0.11702056
97	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.11266681
98	Mineral absorption_Homo sapiens_hsa04978	0.10836768
99	Carbon metabolism_Homo sapiens_hsa01200	0.10638653
100	Morphine addiction_Homo sapiens_hsa05032	0.10277171

PDCD5P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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