PDCD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.40608334
2ribosomal small subunit assembly (GO:0000028)5.17970400
3DNA deamination (GO:0045006)4.92245333
4regulation of cellular amino acid metabolic process (GO:0006521)4.14482349
5pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.13686471
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.11646912
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.08862328
8ribosomal small subunit biogenesis (GO:0042274)4.08126970
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.07897154
10cotranslational protein targeting to membrane (GO:0006613)4.05741170
11protein targeting to ER (GO:0045047)4.00869736
12viral transcription (GO:0019083)4.00030152
13ribosome assembly (GO:0042255)3.97426463
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.92055360
15protein localization to endoplasmic reticulum (GO:0070972)3.91658997
16translational termination (GO:0006415)3.91554685
17maturation of SSU-rRNA (GO:0030490)3.90659159
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.87972560
19protein maturation by protein folding (GO:0022417)3.87185312
20antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.86300397
21ATP synthesis coupled proton transport (GO:0015986)3.79525358
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.79525358
23establishment of protein localization to endoplasmic reticulum (GO:0072599)3.77288038
242-deoxyribonucleotide biosynthetic process (GO:0009265)3.75072327
25deoxyribose phosphate biosynthetic process (GO:0046385)3.75072327
26signal peptide processing (GO:0006465)3.73887455
27pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.73001636
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.68069604
29termination of RNA polymerase III transcription (GO:0006386)3.68069604
30ribosomal large subunit biogenesis (GO:0042273)3.67437264
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.64784649
32positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.61941668
33nucleobase-containing small molecule interconversion (GO:0015949)3.61390505
34signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.57423794
35intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.57423794
36negative regulation of ligase activity (GO:0051352)3.55903478
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.55903478
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.55806083
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.55806083
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.55806083
41protein deneddylation (GO:0000338)3.52044703
42cullin deneddylation (GO:0010388)3.51163338
43translational elongation (GO:0006414)3.50249095
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49264075
45amino acid salvage (GO:0043102)3.48341470
46L-methionine salvage (GO:0071267)3.48341470
47L-methionine biosynthetic process (GO:0071265)3.48341470
48translation (GO:0006412)3.48191613
49respiratory chain complex IV assembly (GO:0008535)3.40675006
50rRNA modification (GO:0000154)3.39964777
51base-excision repair, AP site formation (GO:0006285)3.39654946
52signal transduction involved in DNA integrity checkpoint (GO:0072401)3.39151196
53signal transduction involved in DNA damage checkpoint (GO:0072422)3.39151196
54formation of translation preinitiation complex (GO:0001731)3.35465103
55pyrimidine nucleotide catabolic process (GO:0006244)3.35354591
56signal transduction involved in cell cycle checkpoint (GO:0072395)3.34649144
57GTP biosynthetic process (GO:0006183)3.33908887
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31739560
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.31739560
60NADH dehydrogenase complex assembly (GO:0010257)3.31739560
61protein localization to mitochondrion (GO:0070585)3.30389808
627-methylguanosine mRNA capping (GO:0006370)3.29104814
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28929325
64tRNA methylation (GO:0030488)3.26861307
652-deoxyribonucleotide metabolic process (GO:0009394)3.26294407
66antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.25776970
67deoxyribose phosphate metabolic process (GO:0019692)3.23548859
68RNA capping (GO:0036260)3.23349745
697-methylguanosine RNA capping (GO:0009452)3.23349745
70chaperone-mediated protein transport (GO:0072321)3.22166689
71deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.21491338
72translational initiation (GO:0006413)3.20389444
73regulation of ubiquitin-protein transferase activity (GO:0051438)3.19991466
74deoxyribonucleotide catabolic process (GO:0009264)3.19269605
75viral life cycle (GO:0019058)3.18806759
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.18175568
77deoxyribose phosphate catabolic process (GO:0046386)3.17887112
78respiratory electron transport chain (GO:0022904)3.16651574
79ribonucleoprotein complex biogenesis (GO:0022613)3.14845942
80protein complex biogenesis (GO:0070271)3.14449346
81guanosine-containing compound biosynthetic process (GO:1901070)3.12719411
82DNA strand elongation involved in DNA replication (GO:0006271)3.12391552
83purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.12164904
84regulation of cellular amine metabolic process (GO:0033238)3.11432389
85electron transport chain (GO:0022900)3.10050829
86regulation of ligase activity (GO:0051340)3.09341508
87ribosome biogenesis (GO:0042254)3.07587895
88protein neddylation (GO:0045116)3.06184328
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06018415
90tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05863043
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05863043
92regulation of mitochondrial translation (GO:0070129)3.05805014
93DNA strand elongation (GO:0022616)3.05568421
94deoxyribonucleotide biosynthetic process (GO:0009263)3.05542859
95purine nucleobase biosynthetic process (GO:0009113)3.04429667
96positive regulation of ligase activity (GO:0051351)3.03769839
97mitochondrial respiratory chain complex assembly (GO:0033108)3.02886954
98metallo-sulfur cluster assembly (GO:0031163)3.02048166
99iron-sulfur cluster assembly (GO:0016226)3.02048166
100peptidyl-histidine modification (GO:0018202)3.01508761
101pseudouridine synthesis (GO:0001522)3.01153525
102viral mRNA export from host cell nucleus (GO:0046784)2.98105710
103spliceosomal snRNP assembly (GO:0000387)2.97615868
104deoxyribonucleotide metabolic process (GO:0009262)2.96057077
105cellular component biogenesis (GO:0044085)2.95935376
106regulation of metalloenzyme activity (GO:0048552)2.95459829
107nucleobase biosynthetic process (GO:0046112)2.94976357
108cellular protein complex disassembly (GO:0043624)2.94664915
109aerobic respiration (GO:0009060)2.92418234
110protein targeting to mitochondrion (GO:0006626)2.89266176
111mannosylation (GO:0097502)2.88922133
112melanin biosynthetic process (GO:0042438)2.88669027
113purine deoxyribonucleotide metabolic process (GO:0009151)2.88344783
114cytochrome complex assembly (GO:0017004)2.87170740
115UTP biosynthetic process (GO:0006228)2.86244569
116purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85695519
117maturation of 5.8S rRNA (GO:0000460)2.85481637
118GDP-mannose metabolic process (GO:0019673)2.83569732
119aldehyde catabolic process (GO:0046185)2.83385529
120pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.83180137
121DNA replication checkpoint (GO:0000076)2.82963916
122mitochondrial transport (GO:0006839)2.82927676
123pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.82160975
124rRNA methylation (GO:0031167)2.82079282
125establishment of protein localization to mitochondrion (GO:0072655)2.81947368
126rRNA processing (GO:0006364)2.79941542
127nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.77118710
128deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.76777483
129positive regulation of cell cycle arrest (GO:0071158)2.76654955
130platelet dense granule organization (GO:0060155)2.75253939
131transcription from RNA polymerase I promoter (GO:0006360)2.72897586
132oxidative phosphorylation (GO:0006119)2.72875917
133telomere maintenance via semi-conservative replication (GO:0032201)2.72615276
134DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.69216944
135CTP metabolic process (GO:0046036)2.68874114
136CTP biosynthetic process (GO:0006241)2.68874114
137UTP metabolic process (GO:0046051)2.67419191
138rRNA metabolic process (GO:0016072)2.65698716

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43813911
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.41588743
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.78953701
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.78724378
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.66057463
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.54477689
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51909041
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.32219537
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.32216951
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.22183624
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.08576207
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.06257364
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72550297
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66816086
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.66414640
16* VDR_23849224_ChIP-Seq_CD4+_Human2.59323874
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57724140
18ZNF263_19887448_ChIP-Seq_K562_Human2.55719193
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54606564
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.54392942
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34410180
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.32749970
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.29123535
24DCP1A_22483619_ChIP-Seq_HELA_Human2.27451523
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14350068
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.11620049
27ELK1_19687146_ChIP-ChIP_HELA_Human2.10102911
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09401810
29E2F7_22180533_ChIP-Seq_HELA_Human2.01268822
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99592976
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98043430
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.96484750
33FOXP3_21729870_ChIP-Seq_TREG_Human1.94021945
34XRN2_22483619_ChIP-Seq_HELA_Human1.93728739
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92799112
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.89971803
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.88535343
38* GABP_19822575_ChIP-Seq_HepG2_Human1.87249318
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71761308
40ELK1_22589737_ChIP-Seq_MCF10A_Human1.70977912
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.70554872
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67930036
43* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67107655
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65515248
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.62980773
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60832972
47TTF2_22483619_ChIP-Seq_HELA_Human1.60661788
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.59330512
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58962031
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58781986
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52636577
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.48916253
53GATA1_22025678_ChIP-Seq_K562_Human1.47678805
54ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.46416040
55CIITA_25753668_ChIP-Seq_RAJI_Human1.43776674
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42972433
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41038131
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37806514
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32096133
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31865736
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30454770
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28316651
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.27885148
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.27217018
65* SPI1_23547873_ChIP-Seq_NB4_Human1.23465478
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22438323
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22180379
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20760214
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20696880
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20446377
71AR_21909140_ChIP-Seq_LNCAP_Human1.12889403
72CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12575416
73* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11881815
74* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10636829
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09153401
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07533249
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04614347
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.04522018
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04056884
80TFEB_21752829_ChIP-Seq_HELA_Human1.03633712
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03428786
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03273971
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03193312
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02929017
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02583283
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01556030
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01078774
88MYC_18940864_ChIP-ChIP_HL60_Human1.00649702
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00509597
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99624124
91ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99445760
92IRF1_19129219_ChIP-ChIP_H3396_Human0.98649355
93PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97065179
94VDR_21846776_ChIP-Seq_THP-1_Human0.96785310
95KDM5A_27292631_Chip-Seq_BREAST_Human0.95806780
96FOXP1_21924763_ChIP-Seq_HESCs_Human0.94424497
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93861582
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.92795019
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92679209
100* BCL6_27268052_Chip-Seq_Bcells_Human0.91669789
101MYC_22102868_ChIP-Seq_BL_Human0.91533962
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90682971
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90633601
104ELF5_23300383_ChIP-Seq_T47D_Human0.90270272
105PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89667213
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88996806
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88143278
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87949425
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87479941
110YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86580731
111MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.84376360
112CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83479269
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79620598
114* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78901940
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76025876
116TP63_17297297_ChIP-ChIP_HaCaT_Human0.75631061
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75226502
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75092522
119PPARA_22158963_ChIP-Seq_LIVER_Mouse0.74682698
120RXR_22158963_ChIP-Seq_LIVER_Mouse0.74524569
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.74162537
122TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74030336
123E2F1_21310950_ChIP-Seq_MCF-7_Human0.73601863
124TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.72476772
125CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71961923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.25442890
2MP0003186_abnormal_redox_activity3.40018401
3MP0002877_abnormal_melanocyte_morpholog3.33191805
4MP0003693_abnormal_embryo_hatching3.10387389
5MP0009379_abnormal_foot_pigmentation2.50827023
6MP0009785_altered_susceptibility_to2.47488032
7MP0003111_abnormal_nucleus_morphology2.42852954
8MP0003724_increased_susceptibility_to2.39053982
9MP0002148_abnormal_hypersensitivity_rea2.33678955
10MP0004957_abnormal_blastocyst_morpholog2.17273844
11MP0008875_abnormal_xenobiotic_pharmacok2.14078612
12MP0002139_abnormal_hepatobiliary_system2.09679139
13MP0009840_abnormal_foam_cell2.06292050
14MP0001835_abnormal_antigen_presentation2.05123796
15MP0001853_heart_inflammation2.04440955
16MP0003718_maternal_effect2.04086039
17MP0005360_urolithiasis2.01707299
18MP0003195_calcinosis2.01002621
19MP0005171_absent_coat_pigmentation1.98645004
20MP0009697_abnormal_copulation1.95022217
21MP0005408_hypopigmentation1.83665401
22MP0005083_abnormal_biliary_tract1.81966306
23MP0002132_abnormal_respiratory_system1.78371676
24MP0005671_abnormal_response_to1.75331132
25MP0006036_abnormal_mitochondrial_physio1.71221823
26MP0009333_abnormal_splenocyte_physiolog1.69990663
27MP0005025_abnormal_response_to1.66007365
28MP0001542_abnormal_bone_strength1.65142502
29MP0003656_abnormal_erythrocyte_physiolo1.60050801
30MP0008058_abnormal_DNA_repair1.59172845
31MP0000358_abnormal_cell_content/1.59001010
32MP0000685_abnormal_immune_system1.58837537
33MP0001764_abnormal_homeostasis1.57214333
34MP0003436_decreased_susceptibility_to1.54651263
35MP0003786_premature_aging1.49580609
36MP0005075_abnormal_melanosome_morpholog1.49368354
37MP0004147_increased_porphyrin_level1.49166062
38MP0002419_abnormal_innate_immunity1.48358753
39MP0005000_abnormal_immune_tolerance1.47869603
40MP0000372_irregular_coat_pigmentation1.47468571
41MP0005085_abnormal_gallbladder_physiolo1.44032392
42MP0005451_abnormal_body_composition1.42821667
43MP0005501_abnormal_skin_physiology1.41961420
44MP0002160_abnormal_reproductive_system1.37929070
45MP0004233_abnormal_muscle_weight1.37838527
46MP0000015_abnormal_ear_pigmentation1.37301050
47MP0010234_abnormal_vibrissa_follicle1.36731495
48MP0002019_abnormal_tumor_incidence1.35254135
49MP0001666_abnormal_nutrient_absorption1.33552242
50MP0008932_abnormal_embryonic_tissue1.32077291
51MP0005332_abnormal_amino_acid1.30157576
52MP0000490_abnormal_crypts_of1.29686293
53MP0008469_abnormal_protein_level1.28616738
54MP0005636_abnormal_mineral_homeostasis1.25333133
55MP0002723_abnormal_immune_serum1.25326736
56MP0005058_abnormal_lysosome_morphology1.25031522
57MP0006054_spinal_hemorrhage1.24319989
58MP0002396_abnormal_hematopoietic_system1.23733110
59MP0003191_abnormal_cellular_cholesterol1.23519148
60MP0004019_abnormal_vitamin_homeostasis1.22075922
61MP0004381_abnormal_hair_follicle1.20802068
62MP0008260_abnormal_autophagy1.20538006
63MP0001819_abnormal_immune_cell1.19449796
64MP0002420_abnormal_adaptive_immunity1.19386016
65MP0003763_abnormal_thymus_physiology1.18523736
66MP0001845_abnormal_inflammatory_respons1.17332625
67MP0005084_abnormal_gallbladder_morpholo1.16764688
68MP0001986_abnormal_taste_sensitivity1.16180123
69MP0000681_abnormal_thyroid_gland1.16060011
70MP0000678_abnormal_parathyroid_gland1.16036379
71MP0001661_extended_life_span1.14648210
72MP0005365_abnormal_bile_salt1.14413881
73MP0006082_CNS_inflammation1.14399772
74MP0004782_abnormal_surfactant_physiolog1.14303040
75MP0002452_abnormal_antigen_presenting1.13797192
76MP0000371_diluted_coat_color1.13213252
77MP0006035_abnormal_mitochondrial_morpho1.12828637
78MP0001873_stomach_inflammation1.12796197
79MP0002163_abnormal_gland_morphology1.12725958
80MP0000350_abnormal_cell_proliferation1.11246997
81MP0008007_abnormal_cellular_replicative1.09759808
82MP0009643_abnormal_urine_homeostasis1.08978457
83MP0000313_abnormal_cell_death1.08152129
84MP0003077_abnormal_cell_cycle1.07800490
85MP0002095_abnormal_skin_pigmentation1.07586583
86MP0002166_altered_tumor_susceptibility1.06358361
87MP0003136_yellow_coat_color1.04849983
88MP0001545_abnormal_hematopoietic_system1.04431236
89MP0005397_hematopoietic_system_phenotyp1.04431236
90MP0002796_impaired_skin_barrier1.04395577
91MP0001533_abnormal_skeleton_physiology1.03832811
92MP0010155_abnormal_intestine_physiology1.03386015
93MP0008872_abnormal_physiological_respon1.03229323
94MP0002405_respiratory_system_inflammati1.00350713
95MP0001800_abnormal_humoral_immune0.99561918
96MP0002933_joint_inflammation0.99181866
97MP0000716_abnormal_immune_system0.97059840
98MP0010094_abnormal_chromosome_stability0.96625376
99MP0000465_gastrointestinal_hemorrhage0.95772369
100MP0001905_abnormal_dopamine_level0.95379965
101MP0001243_abnormal_dermal_layer0.93591036
102MP0005387_immune_system_phenotype0.93090402
103MP0001790_abnormal_immune_system0.93090402
104MP0001216_abnormal_epidermal_layer0.92913141
105MP0009765_abnormal_xenobiotic_induced0.92555843
106MP0002138_abnormal_hepatobiliary_system0.92485417
107MP0000689_abnormal_spleen_morphology0.92458697
108MP0005319_abnormal_enzyme/_coenzyme0.92240841
109MP0002429_abnormal_blood_cell0.91353337
110MP0005379_endocrine/exocrine_gland_phen0.89591873
111MP0005389_reproductive_system_phenotype0.89168084
112MP0002098_abnormal_vibrissa_morphology0.89030018
113MP0002876_abnormal_thyroid_physiology0.89012187
114MP0005464_abnormal_platelet_physiology0.88240315
115MP0002722_abnormal_immune_system0.88148833
116MP0008873_increased_physiological_sensi0.88009438
117MP0001881_abnormal_mammary_gland0.87464589
118MP0002398_abnormal_bone_marrow0.87310779
119MP0001919_abnormal_reproductive_system0.85659698
120MP0009764_decreased_sensitivity_to0.85624615
121MP0002938_white_spotting0.84954925
122MP0008057_abnormal_DNA_replication0.84837943
123MP0001186_pigmentation_phenotype0.84425328
124MP0002080_prenatal_lethality0.84242214
125MP0000858_altered_metastatic_potential0.83453713
126MP0005584_abnormal_enzyme/coenzyme_acti0.83330476
127MP0005410_abnormal_fertilization0.83144004
128MP0009763_increased_sensitivity_to0.83090145
129MP0002075_abnormal_coat/hair_pigmentati0.81846550
130MP0001663_abnormal_digestive_system0.80684676
131MP0003866_abnormal_defecation0.79859502
132MP0002060_abnormal_skin_morphology0.78465798
133MP0010771_integument_phenotype0.76649955
134MP0010307_abnormal_tumor_latency0.75570623
135MP0005330_cardiomyopathy0.74032298
136MP0005384_cellular_phenotype0.72046915
137MP0000703_abnormal_thymus_morphology0.69953266
138MP0000367_abnormal_coat/_hair0.69896490
139MP0000609_abnormal_liver_physiology0.69885481
140MP0001727_abnormal_embryo_implantation0.67729509
141MP0001697_abnormal_embryo_size0.67668949
142MP0002006_tumorigenesis0.67627932
143MP0000627_abnormal_mammary_gland0.66673224
144MP0000003_abnormal_adipose_tissue0.66646875
145MP0001730_embryonic_growth_arrest0.65199019
146MP0000343_altered_response_to0.62778941

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.91402471
2Hepatic necrosis (HP:0002605)3.82859054
3Abnormality of cells of the erythroid lineage (HP:0012130)3.81309819
43-Methylglutaconic aciduria (HP:0003535)3.80041439
5Hepatocellular necrosis (HP:0001404)3.76552137
6Mitochondrial inheritance (HP:0001427)3.74729325
7Decreased activity of mitochondrial respiratory chain (HP:0008972)3.72326389
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.72326389
9Abnormal mitochondria in muscle tissue (HP:0008316)3.65353973
10Abnormal number of erythroid precursors (HP:0012131)3.61229049
11Acute encephalopathy (HP:0006846)3.46006361
12Increased CSF lactate (HP:0002490)3.41784542
13Increased hepatocellular lipid droplets (HP:0006565)3.27264289
14Ragged-red muscle fibers (HP:0003200)3.26024230
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.15651034
16Progressive macrocephaly (HP:0004481)3.10915430
17Lipid accumulation in hepatocytes (HP:0006561)3.10613321
18Renal Fanconi syndrome (HP:0001994)3.08340312
19Increased serum lactate (HP:0002151)3.02961430
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.98044510
21Generalized aminoaciduria (HP:0002909)2.95427628
22Reduced antithrombin III activity (HP:0001976)2.89699587
23Abnormality of aromatic amino acid family metabolism (HP:0004338)2.89542769
24Reticulocytopenia (HP:0001896)2.86851396
25Type I transferrin isoform profile (HP:0003642)2.83830352
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.83029016
27Irregular epiphyses (HP:0010582)2.78290641
28Poor head control (HP:0002421)2.77899892
29Aplastic anemia (HP:0001915)2.72182519
30Macrocytic anemia (HP:0001972)2.71306645
31Lactic acidosis (HP:0003128)2.70533296
32Testicular atrophy (HP:0000029)2.65207794
33Neoplasm of head and neck (HP:0012288)2.64215256
34Esophageal neoplasm (HP:0100751)2.64215256
35Vacuolated lymphocytes (HP:0001922)2.62610199
36Increased intramyocellular lipid droplets (HP:0012240)2.62512340
37Cerebral edema (HP:0002181)2.57917036
38Increased serum pyruvate (HP:0003542)2.56178512
39Abnormality of glycolysis (HP:0004366)2.56178512
40Exertional dyspnea (HP:0002875)2.53825276
41Congenital ichthyosiform erythroderma (HP:0007431)2.48062831
42Respiratory failure (HP:0002878)2.46366423
43Hyperammonemia (HP:0001987)2.43991899
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.42726530
45Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42208991
46Abnormal protein N-linked glycosylation (HP:0012347)2.42208991
47Abnormal protein glycosylation (HP:0012346)2.42208991
48Abnormal glycosylation (HP:0012345)2.42208991
49Glycosuria (HP:0003076)2.39965609
50Abnormality of urine glucose concentration (HP:0011016)2.39965609
51Increased muscle lipid content (HP:0009058)2.39086809
52Exercise intolerance (HP:0003546)2.37594168
53Prolonged neonatal jaundice (HP:0006579)2.36062304
54Rough bone trabeculation (HP:0100670)2.35744519
55Parakeratosis (HP:0001036)2.34261185
56Carpal bone hypoplasia (HP:0001498)2.34100694
57Elevated erythrocyte sedimentation rate (HP:0003565)2.31516496
58Emotional lability (HP:0000712)2.26126667
59Microvesicular hepatic steatosis (HP:0001414)2.23674300
60Microretrognathia (HP:0000308)2.23114058
61Hypokinesia (HP:0002375)2.22823898
62Patchy hypopigmentation of hair (HP:0011365)2.22585337
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19462919
64Abnormality of alanine metabolism (HP:0010916)2.19462919
65Hyperalaninemia (HP:0003348)2.19462919
66Pallor (HP:0000980)2.16771434
67Cerebral hypomyelination (HP:0006808)2.16525520
68Lethargy (HP:0001254)2.16485405
69Abnormality of renal resorption (HP:0011038)2.16240193
70Hypobetalipoproteinemia (HP:0003563)2.14124318
71Petechiae (HP:0000967)2.13484496
72Progressive microcephaly (HP:0000253)2.13146112
73Beaking of vertebral bodies (HP:0004568)2.12652933
74Birth length less than 3rd percentile (HP:0003561)2.10217908
75Spastic paraparesis (HP:0002313)2.09546692
76Dicarboxylic aciduria (HP:0003215)2.07897987
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07897987
78Sparse eyelashes (HP:0000653)2.05921435
79Cutaneous melanoma (HP:0012056)2.05403988
80CNS demyelination (HP:0007305)2.02313543
81Respiratory difficulties (HP:0002880)2.00726518
82Optic disc pallor (HP:0000543)2.00632840
83Oral leukoplakia (HP:0002745)1.98226008
84Pancytopenia (HP:0001876)1.97346758
85Abnormal trabecular bone morphology (HP:0100671)1.97067775
86Autoamputation (HP:0001218)1.96914802
87Leukodystrophy (HP:0002415)1.96527900
88Hepatosplenomegaly (HP:0001433)1.96157716
89White forelock (HP:0002211)1.95696137
90Vertebral compression fractures (HP:0002953)1.93778080
91Progressive muscle weakness (HP:0003323)1.91458031
92Thrombocytosis (HP:0001894)1.91150184
93Gliosis (HP:0002171)1.90720059
94Abnormality of methionine metabolism (HP:0010901)1.89855845
95Alkalosis (HP:0001948)1.89037055
96Concave nail (HP:0001598)1.87280085
97Vomiting (HP:0002013)1.86256363
98Megaloblastic anemia (HP:0001889)1.86194205
99Acute hepatic failure (HP:0006554)1.85331465
100Delayed epiphyseal ossification (HP:0002663)1.85166814
101Premature graying of hair (HP:0002216)1.85157015
102Death in infancy (HP:0001522)1.84942792
103Metaphyseal dysplasia (HP:0100255)1.84053245
104Abnormality of macrophages (HP:0004311)1.83518432
105Abnormality of fatty-acid metabolism (HP:0004359)1.83259368
106Breast hypoplasia (HP:0003187)1.83070388
107Abnormal tarsal ossification (HP:0008369)1.82521017
108Recurrent abscess formation (HP:0002722)1.81881281
109Steatorrhea (HP:0002570)1.80964939
110Methylmalonic aciduria (HP:0012120)1.79931972
111Opisthotonus (HP:0002179)1.77913931
112Abnormality of monocarboxylic acid metabolism (HP:0010996)1.77817401
113Trismus (HP:0000211)1.77528564
114Recurrent bacterial skin infections (HP:0005406)1.76231768
115Abnormality of liposaccharide metabolism (HP:0010968)1.76108067
116Abnormality of glycosphingolipid metabolism (HP:0004343)1.76108067
117Abnormality of glycolipid metabolism (HP:0010969)1.76108067
118Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74520853
119Postnatal microcephaly (HP:0005484)1.73704350
120Abnormality of the heme biosynthetic pathway (HP:0010472)1.73694885
121Entropion (HP:0000621)1.73451819
12211 pairs of ribs (HP:0000878)1.72375341
123Stenosis of the external auditory canal (HP:0000402)1.72045470
124Cerebellar dysplasia (HP:0007033)1.71300396
125Abnormality of the anterior horn cell (HP:0006802)1.71199263
126Degeneration of anterior horn cells (HP:0002398)1.71199263
127Abnormality of serum amino acid levels (HP:0003112)1.69624103
128Hyperphosphaturia (HP:0003109)1.68590678
129Aplasia/hypoplasia of the uterus (HP:0008684)1.68533472
130Intrahepatic cholestasis (HP:0001406)1.67937373
131Abnormality of the preputium (HP:0100587)1.67454877
132Premature ovarian failure (HP:0008209)1.67286835
133Abnormality of the distal phalanges of the toes (HP:0010182)1.65575602
134Brittle hair (HP:0002299)1.65147147
135Micronodular cirrhosis (HP:0001413)1.62159151
136Abnormal hair laboratory examination (HP:0003328)1.58877469
137Hypertensive crisis (HP:0100735)1.56897404
138Squamous cell carcinoma (HP:0002860)1.54081366
139Aplasia/Hypoplasia of the fovea (HP:0008060)1.53522447

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK23.82878015
2NME23.76262223
3STK163.74304500
4SCYL23.72565817
5BUB13.50146030
6EIF2AK13.17643532
7EIF2AK32.66235367
8PIM22.63460909
9MST42.63092561
10VRK22.56393217
11PBK2.49064012
12WEE12.47221024
13TESK22.35174112
14MST1R2.27893645
15NME12.23849125
16NEK12.16828587
17VRK12.07690002
18ARAF2.07101754
19BCKDK1.80955676
20EPHA21.69693547
21IRAK41.63286028
22PAK41.55644372
23ACVR1B1.55273086
24BRSK21.45104343
25MAPKAPK31.39115059
26MAP3K31.34187551
27KDR1.33204807
28SRPK11.32076891
29MAP3K121.31262462
30DAPK11.30335139
31TEC1.29049096
32PLK41.28559229
33MET1.27548628
34BLK1.24288773
35NUAK11.24035037
36IRAK31.22656494
37CDK191.21183543
38DYRK31.18573195
39BCR1.18453067
40BRAF1.15817798
41BMPR21.15464919
42LIMK11.07233916
43RPS6KA41.06748887
44TESK11.05942546
45MAP4K21.03796195
46TSSK61.03119807
47CDC71.02175234
48RPS6KB21.00477707
49MAP3K140.97125705
50CCNB10.97016522
51TXK0.94675256
52CSNK1A1L0.94425346
53ZAK0.93568276
54TBK10.91346171
55MKNK10.89959198
56MAPKAPK50.87576637
57ATR0.87335668
58IRAK10.85534932
59IKBKB0.84909902
60MAP3K110.83007430
61EIF2AK20.82115625
62MAP2K20.82001272
63BMPR1B0.80797860
64ABL20.80705386
65PIK3CA0.79991680
66MYLK0.78689395
67MAP4K10.76151829
68STK240.75265620
69TLK10.74835464
70LRRK20.73117328
71MAPK150.70996652
72TTK0.70540974
73CDK80.70240696
74ADRBK20.70016274
75NEK60.69948009
76KIT0.69802134
77PASK0.69346147
78NEK90.69131299
79RPS6KA50.69001950
80AURKA0.68497734
81CSNK1G30.67677738
82ZAP700.67009947
83ERBB30.66488341
84DYRK20.66103113
85BTK0.65886790
86NLK0.65818682
87GRK60.64631444
88SMG10.63829195
89CAMKK20.63470222
90ERN10.62386714
91AURKB0.62294040
92PRKG20.61295881
93PIK3CG0.61186025
94CSNK1G20.59118542
95ILK0.58985335
96FLT30.58621703
97OXSR10.58523345
98MAPK110.58421968
99CSNK2A10.57884168
100WNK40.57534010
101CLK10.56951497
102MAP3K20.56759728
103IKBKE0.56576265
104PAK10.55186432
105PLK30.54127410
106STK390.54062383
107LYN0.53886599
108PLK10.52200251
109CHEK20.50489955
110SIK30.50305926
111PRKCI0.49270700
112NEK20.49134288
113RAF10.48102312
114CAMK2G0.46978784
115FRK0.45083024
116RIPK40.44277239
117MAP3K80.44244154
118CSNK1G10.43987512
119MUSK0.43740413
120STK100.43663697
121PIM10.43199096
122TYK20.42781211
123CSNK2A20.40985127
124SYK0.40836793
125BRSK10.40826972
126MAP2K60.40582100
127TRIM280.40411555
128MARK30.39782280
129CDK70.39486919
130MKNK20.39484526
131CDK40.38391725
132LMTK20.37353895
133DAPK30.26648662
134AKT20.25742554
135TAOK30.25358384
136CHEK10.23585312
137CAMK2D0.21258376
138MAPKAPK20.20495299
139CAMK2B0.20454236
140GRK50.19314578

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.62380953
2Ribosome_Homo sapiens_hsa030103.97572261
3Protein export_Homo sapiens_hsa030603.36198776
4RNA polymerase_Homo sapiens_hsa030203.32396202
5Oxidative phosphorylation_Homo sapiens_hsa001902.70771019
6Folate biosynthesis_Homo sapiens_hsa007902.42274650
7DNA replication_Homo sapiens_hsa030302.35551680
8Parkinsons disease_Homo sapiens_hsa050122.33182022
9Pyrimidine metabolism_Homo sapiens_hsa002402.30726538
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10675898
11Mismatch repair_Homo sapiens_hsa034302.02064683
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95114786
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.91389933
14Sulfur metabolism_Homo sapiens_hsa009201.71266579
15Huntingtons disease_Homo sapiens_hsa050161.70927232
16Nucleotide excision repair_Homo sapiens_hsa034201.61128826
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58476776
18Glutathione metabolism_Homo sapiens_hsa004801.56073281
19Biosynthesis of amino acids_Homo sapiens_hsa012301.53457046
20Homologous recombination_Homo sapiens_hsa034401.52699014
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50045411
22Alzheimers disease_Homo sapiens_hsa050101.49304306
23Base excision repair_Homo sapiens_hsa034101.45104879
24Spliceosome_Homo sapiens_hsa030401.44885028
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35862102
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34939841
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31360348
28Fatty acid elongation_Homo sapiens_hsa000621.29902584
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.27185703
30Purine metabolism_Homo sapiens_hsa002301.25656074
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23745288
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20275329
33Steroid biosynthesis_Homo sapiens_hsa001001.18449097
34Basal transcription factors_Homo sapiens_hsa030221.13865083
35RNA transport_Homo sapiens_hsa030131.07262309
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06083753
37Histidine metabolism_Homo sapiens_hsa003401.05821628
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05323915
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05268162
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05073538
41Sulfur relay system_Homo sapiens_hsa041221.04647634
42Caffeine metabolism_Homo sapiens_hsa002321.04275170
43Chemical carcinogenesis_Homo sapiens_hsa052040.99564151
44Arachidonic acid metabolism_Homo sapiens_hsa005900.99457061
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.97042074
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95829180
47Pentose phosphate pathway_Homo sapiens_hsa000300.91602139
48Peroxisome_Homo sapiens_hsa041460.90282901
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83874461
50Metabolic pathways_Homo sapiens_hsa011000.83842718
51Arginine biosynthesis_Homo sapiens_hsa002200.83574680
52Non-homologous end-joining_Homo sapiens_hsa034500.82466696
53Vitamin digestion and absorption_Homo sapiens_hsa049770.82234775
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81242318
55RNA degradation_Homo sapiens_hsa030180.80845396
56Legionellosis_Homo sapiens_hsa051340.80686164
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78029575
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75563974
59One carbon pool by folate_Homo sapiens_hsa006700.74479673
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73952466
61Other glycan degradation_Homo sapiens_hsa005110.73874613
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72945445
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72341381
64Vitamin B6 metabolism_Homo sapiens_hsa007500.72043383
65Graft-versus-host disease_Homo sapiens_hsa053320.71981169
66Regulation of autophagy_Homo sapiens_hsa041400.71245454
67Linoleic acid metabolism_Homo sapiens_hsa005910.69979547
68Sphingolipid metabolism_Homo sapiens_hsa006000.69570761
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69313716
70Primary immunodeficiency_Homo sapiens_hsa053400.69119849
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.68911916
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.68375607
73Allograft rejection_Homo sapiens_hsa053300.65198513
74Arginine and proline metabolism_Homo sapiens_hsa003300.63839942
75beta-Alanine metabolism_Homo sapiens_hsa004100.62632622
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62473850
77Epstein-Barr virus infection_Homo sapiens_hsa051690.59984692
78Systemic lupus erythematosus_Homo sapiens_hsa053220.59757752
79Selenocompound metabolism_Homo sapiens_hsa004500.58670565
80p53 signaling pathway_Homo sapiens_hsa041150.57563625
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.56950599
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.55610122
83Shigellosis_Homo sapiens_hsa051310.54221204
84Asthma_Homo sapiens_hsa053100.53701256
85Pyruvate metabolism_Homo sapiens_hsa006200.53531129
86Galactose metabolism_Homo sapiens_hsa000520.53430540
87Renin-angiotensin system_Homo sapiens_hsa046140.52797566
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52661879
89Retinol metabolism_Homo sapiens_hsa008300.51496591
90Vibrio cholerae infection_Homo sapiens_hsa051100.51306891
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50715360
92Rheumatoid arthritis_Homo sapiens_hsa053230.50583232
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.49146749
94Carbon metabolism_Homo sapiens_hsa012000.46422437
95Cell cycle_Homo sapiens_hsa041100.45634394
96Antigen processing and presentation_Homo sapiens_hsa046120.45619000
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45610772
98N-Glycan biosynthesis_Homo sapiens_hsa005100.44892947
99Nitrogen metabolism_Homo sapiens_hsa009100.44614696
100Fatty acid metabolism_Homo sapiens_hsa012120.44022398
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43523604
102Fructose and mannose metabolism_Homo sapiens_hsa000510.42397323
103Fanconi anemia pathway_Homo sapiens_hsa034600.42389137
104Phenylalanine metabolism_Homo sapiens_hsa003600.41968456
105Cardiac muscle contraction_Homo sapiens_hsa042600.41828309
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.41295832
107Ether lipid metabolism_Homo sapiens_hsa005650.40876579
108Fat digestion and absorption_Homo sapiens_hsa049750.40386935
109Collecting duct acid secretion_Homo sapiens_hsa049660.39225591
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39146931
111Tyrosine metabolism_Homo sapiens_hsa003500.38490241
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37814979
113Propanoate metabolism_Homo sapiens_hsa006400.37528290
114Pertussis_Homo sapiens_hsa051330.37217860
115Herpes simplex infection_Homo sapiens_hsa051680.33065182
116Autoimmune thyroid disease_Homo sapiens_hsa053200.32947647
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25237285
118Lysosome_Homo sapiens_hsa041420.22866562
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20579232
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20117726
121mRNA surveillance pathway_Homo sapiens_hsa030150.18769197
122Viral carcinogenesis_Homo sapiens_hsa052030.16950229

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