PDCD6IP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.22911755
2COPI coating of Golgi vesicle (GO:0048205)4.22911755
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.95944029
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.95944029
5hypotonic response (GO:0006971)3.92538792
6nuclear pore complex assembly (GO:0051292)3.75927286
7barbed-end actin filament capping (GO:0051016)3.62487506
8desmosome organization (GO:0002934)3.61189688
9embryonic process involved in female pregnancy (GO:0060136)3.49163044
10antigen processing and presentation of endogenous antigen (GO:0019883)3.45534291
11iron ion import (GO:0097286)3.41922987
12negative regulation of fatty acid transport (GO:2000192)3.39736533
13nuclear pore organization (GO:0006999)3.29316024
14low-density lipoprotein particle clearance (GO:0034383)3.29168064
15negative regulation of protein localization to plasma membrane (GO:1903077)3.23763044
16regulation of cholesterol homeostasis (GO:2000188)3.20669560
17apoptotic cell clearance (GO:0043277)3.19179525
18growth hormone receptor signaling pathway (GO:0060396)3.17641704
19cell adhesion mediated by integrin (GO:0033627)3.16619241
20positive regulation of histone deacetylation (GO:0031065)3.07261286
21cytoskeletal anchoring at plasma membrane (GO:0007016)3.07075867
22protein localization to endosome (GO:0036010)3.05612143
23glycosphingolipid catabolic process (GO:0046479)3.05507185
24skin morphogenesis (GO:0043589)3.03607173
25hemidesmosome assembly (GO:0031581)3.03441421
26response to laminar fluid shear stress (GO:0034616)2.98189878
27activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.81704059
28glycolipid catabolic process (GO:0019377)2.80757857
29regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.79116234
30cellular response to growth hormone stimulus (GO:0071378)2.78746355
31regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.78425806
32pore complex assembly (GO:0046931)2.78361744
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.74425468
34positive regulation of nuclease activity (GO:0032075)2.72106661
35regulation of cholesterol storage (GO:0010885)2.70461736
36peptide catabolic process (GO:0043171)2.69444221
37response to thyroid hormone (GO:0097066)2.67827573
38membrane raft organization (GO:0031579)2.64796502
39positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.64249624
40cell-substrate junction assembly (GO:0007044)2.63964436
41endodermal cell differentiation (GO:0035987)2.62034149
42JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.60431898
43cellular response to thyroid hormone stimulus (GO:0097067)2.58957295
44hepatocyte apoptotic process (GO:0097284)2.55917174
45endoplasmic reticulum unfolded protein response (GO:0030968)2.55859993
46positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.55634401
47membrane protein ectodomain proteolysis (GO:0006509)2.54043708
48protein retention in ER lumen (GO:0006621)2.52947771
49positive regulation of p38MAPK cascade (GO:1900745)2.52499121
50COPII vesicle coating (GO:0048208)2.50673220
51surfactant homeostasis (GO:0043129)2.50615848
52regulation of nuclease activity (GO:0032069)2.48441067
53regulation of gamma-delta T cell differentiation (GO:0045586)2.47755015
54regulation of membrane protein ectodomain proteolysis (GO:0051043)2.47628764
55cell-substrate adherens junction assembly (GO:0007045)2.47053815
56focal adhesion assembly (GO:0048041)2.47053815
57negative regulation of erythrocyte differentiation (GO:0045647)2.46862363
58oligosaccharide catabolic process (GO:0009313)2.45685494
59retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.45117088
60positive regulation of Cdc42 GTPase activity (GO:0043089)2.43865209
61regulation of histone H3-K27 methylation (GO:0061085)2.43561440
62Arp2/3 complex-mediated actin nucleation (GO:0034314)2.43262705
63bundle of His cell to Purkinje myocyte communication (GO:0086069)2.42835376
64negative regulation of anoikis (GO:2000811)2.42747339
65regulation of interleukin-12 biosynthetic process (GO:0045075)2.42627784
66cellular response to unfolded protein (GO:0034620)2.41285731
67positive regulation of receptor recycling (GO:0001921)2.41034772
68negative regulation of lipid transport (GO:0032369)2.40456743
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.40073291
70positive regulation of natural killer cell differentiation (GO:0032825)2.39658451
71negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.39468656
72positive regulation of interferon-alpha production (GO:0032727)2.38813103
734-hydroxyproline metabolic process (GO:0019471)2.37050126
74regulation of protein heterodimerization activity (GO:0043497)2.36882373
75positive regulation of cellular amide metabolic process (GO:0034250)2.34766254
76regulation of protein localization to plasma membrane (GO:1903076)2.34357378
77pentose-phosphate shunt (GO:0006098)2.34343487
78ER-nucleus signaling pathway (GO:0006984)2.33981669
79gland morphogenesis (GO:0022612)2.33658435
80maternal placenta development (GO:0001893)2.31748226
81ceramide catabolic process (GO:0046514)2.31621502
82regulation of nucleobase-containing compound transport (GO:0032239)2.31081582
83positive regulation of endothelial cell apoptotic process (GO:2000353)2.29607675
84antigen processing and presentation via MHC class Ib (GO:0002475)2.29540030
85alpha-linolenic acid metabolic process (GO:0036109)2.28815797
86regulation of interferon-alpha production (GO:0032647)2.28489795
87response to peptidoglycan (GO:0032494)2.26849649
88regulation of RNA export from nucleus (GO:0046831)2.26743102
89positive regulation of gamma-delta T cell activation (GO:0046645)2.26367839
90protein hydroxylation (GO:0018126)2.26247280
91basement membrane organization (GO:0071711)2.25742224
92activation of Rac GTPase activity (GO:0032863)2.24662172
93regulation of transforming growth factor beta1 production (GO:0032908)2.23611919
94hyaluronan catabolic process (GO:0030214)2.23401756
95mammary gland epithelial cell proliferation (GO:0033598)2.23167151
96proline biosynthetic process (GO:0006561)2.22496026
97cortical actin cytoskeleton organization (GO:0030866)2.21689747
98protein carboxylation (GO:0018214)2.21561257
99peptidyl-glutamic acid carboxylation (GO:0017187)2.21561257
100establishment of endothelial barrier (GO:0061028)2.20807356
101negative regulation of fibrinolysis (GO:0051918)2.20054966
102epithelial cell differentiation involved in prostate gland development (GO:0060742)2.19998203
103negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.19659868
104positive regulation of extracellular matrix organization (GO:1903055)2.19122142
105positive regulation of leukocyte degranulation (GO:0043302)2.19035553
106lipopolysaccharide-mediated signaling pathway (GO:0031663)2.18971295
107cellular response to topologically incorrect protein (GO:0035967)2.18834100
108regulation of water loss via skin (GO:0033561)2.18188577
109fibril organization (GO:0097435)2.18118085
110positive regulation of protein deacetylation (GO:0090312)2.18054480
111regulation of extracellular matrix disassembly (GO:0010715)2.18019612
112mannose metabolic process (GO:0006013)2.17822735
113mesodermal cell differentiation (GO:0048333)2.17781789
114regulation of fatty acid beta-oxidation (GO:0031998)2.17645220
115epithelial cell-cell adhesion (GO:0090136)2.17111932
116adhesion of symbiont to host (GO:0044406)2.16857788
117positive regulation of lamellipodium assembly (GO:0010592)2.16538039
118regulation of anoikis (GO:2000209)2.14912854
119substrate adhesion-dependent cell spreading (GO:0034446)2.14684293
120cellular response to vitamin (GO:0071295)2.14319043
121regulation of leukocyte degranulation (GO:0043300)2.14100480
122localization within membrane (GO:0051668)2.13738559
123dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.13061128
124regulation of necrotic cell death (GO:0010939)2.12822515
125positive regulation of bone remodeling (GO:0046852)2.12722033
126positive regulation of bone resorption (GO:0045780)2.12722033
127positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.12629978
128wound healing, spreading of epidermal cells (GO:0035313)2.12188484
129positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.12020172
130cellular copper ion homeostasis (GO:0006878)2.11981097
131positive regulation of fatty acid beta-oxidation (GO:0032000)2.11335096
132negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.11263144
133regulation of interferon-beta biosynthetic process (GO:0045357)2.11037159
134integrin-mediated signaling pathway (GO:0007229)2.10812525
135peptidyl-proline hydroxylation (GO:0019511)2.10782111
136cellular response to vitamin D (GO:0071305)2.10622983
137intestinal cholesterol absorption (GO:0030299)2.10562159
138vascular endothelial growth factor signaling pathway (GO:0038084)2.09760292
139regulation of early endosome to late endosome transport (GO:2000641)2.09460994
140response to fluid shear stress (GO:0034405)2.09111323
141NADPH regeneration (GO:0006740)2.08586731
142regulation of gamma-delta T cell activation (GO:0046643)2.08150608
143pinocytosis (GO:0006907)2.07998880
144receptor catabolic process (GO:0032801)2.07880910
145germ cell migration (GO:0008354)2.07345220
146regulation of necroptotic process (GO:0060544)2.07129064
147plasma lipoprotein particle clearance (GO:0034381)2.06965983
148stress fiber assembly (GO:0043149)2.06959016
149positive regulation of blood vessel endothelial cell migration (GO:0043536)2.06838792
150virion attachment to host cell (GO:0019062)2.06353505
151adhesion of symbiont to host cell (GO:0044650)2.06353505
152vesicle coating (GO:0006901)2.06200406
153regulation of vitamin metabolic process (GO:0030656)2.04815869
154definitive hemopoiesis (GO:0060216)2.04086177
155positive regulation of triglyceride biosynthetic process (GO:0010867)2.02707547
156regulation of glucose import in response to insulin stimulus (GO:2001273)2.01384530
157response to muramyl dipeptide (GO:0032495)2.00741755
158response to growth hormone (GO:0060416)2.00232691
159sequestering of metal ion (GO:0051238)1.99809435
160adherens junction assembly (GO:0034333)1.99537981
161response to endoplasmic reticulum stress (GO:0034976)1.98634130

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.62028115
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.68919349
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.22802182
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.21433545
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.72978272
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.53460213
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.49376990
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.48623177
9* CLOCK_20551151_ChIP-Seq_293T_Human2.45488168
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.44552767
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.44506116
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.36530170
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.30542001
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.30309064
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.28454105
16MYC_22102868_ChIP-Seq_BL_Human2.15493597
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.11756953
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.04217740
19ELK3_25401928_ChIP-Seq_HUVEC_Human1.96812467
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96162830
21MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93124134
22VDR_21846776_ChIP-Seq_THP-1_Human1.91030926
23AR_21909140_ChIP-Seq_LNCAP_Human1.89869607
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.85248153
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79461415
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77872969
27TCF7_22412390_ChIP-Seq_EML_Mouse1.77325891
28MAF_26560356_Chip-Seq_TH1_Human1.70772544
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70611362
30* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69904096
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.68611506
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66852146
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.65677094
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65599945
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.64976178
36E2F7_22180533_ChIP-Seq_HELA_Human1.63362593
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.63254006
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61562243
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.61312188
40TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61014534
41VDR_24763502_ChIP-Seq_THP-1_Human1.59114172
42KDM2B_26808549_Chip-Seq_DND41_Human1.58785400
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.58681699
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57363979
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.57136754
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.54173586
47RACK7_27058665_Chip-Seq_MCF-7_Human1.54133423
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52738260
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51865454
50UTX_26944678_Chip-Seq_JUKART_Human1.50667816
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.50327953
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.49476605
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.49031780
54SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47112612
55MYB_26560356_Chip-Seq_TH2_Human1.47020587
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46667747
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46221254
58RUNX_20019798_ChIP-Seq_JUKART_Human1.46088751
59ATF3_27146783_Chip-Seq_COLON_Human1.44993454
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40497615
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40348234
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.38261333
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37925165
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37028859
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36489332
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36489332
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36261279
68SCL_19346495_ChIP-Seq_HPC-7_Human1.35572700
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33798116
70* TFEB_21752829_ChIP-Seq_HELA_Human1.33313335
71* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32899755
72GATA6_25053715_ChIP-Seq_YYC3_Human1.30415473
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.29951934
74LXR_22292898_ChIP-Seq_THP-1_Human1.29323073
75MYB_26560356_Chip-Seq_TH1_Human1.29146980
76WT1_19549856_ChIP-ChIP_CCG9911_Human1.26588143
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23775738
78ZNF263_19887448_ChIP-Seq_K562_Human1.23382151
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20586015
80FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.19799767
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19497504
82* GATA1_19941826_ChIP-Seq_K562_Human1.19451748
83* RUNX1_22412390_ChIP-Seq_EML_Mouse1.19446409
84EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.19351521
85FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18025152
86SPI1_23127762_ChIP-Seq_K562_Human1.15906068
87GATA4_25053715_ChIP-Seq_YYC3_Human1.14920382
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14621491
89* NCOR1_26117541_ChIP-Seq_K562_Human1.14345460
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14105325
91* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13896385
92SPI1_23547873_ChIP-Seq_NB4_Human1.13139925
93SOX2_20726797_ChIP-Seq_SW620_Human1.12998488
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12888179
95BP1_19119308_ChIP-ChIP_Hs578T_Human1.12371475
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11983268
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10117421
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09384988
99* BRD4_25478319_ChIP-Seq_HGPS_Human1.09001621
100* CHD1_26751641_Chip-Seq_LNCaP_Human1.08310723
101P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08033606
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07852873
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07661371
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07050266
105* UBF1/2_26484160_Chip-Seq_HMECs_Human1.05997019
106NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05862989
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05516142
108CDX2_20551321_ChIP-Seq_CACO-2_Human1.05014161
109* GATA2_19941826_ChIP-Seq_K562_Human1.03586884
110KDM2B_26808549_Chip-Seq_JURKAT_Human1.03268413
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02545504
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02124246
113RUNX1_27514584_Chip-Seq_MCF-7_Human1.01606249
114TBX20_22328084_ChIP-Seq_HEART_Mouse1.01315727
115TBX20_22080862_ChIP-Seq_HEART_Mouse1.01315727
116STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00625743
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99590908
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98818826
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98735815
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98626474
121GATA1_22025678_ChIP-Seq_K562_Human0.98466195
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98459994
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98415566
124PU_27001747_Chip-Seq_BMDM_Mouse0.98000416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.37920396
2MP0003300_gastrointestinal_ulcer3.24924254
3MP0008438_abnormal_cutaneous_collagen2.68389854
4MP0010352_gastrointestinal_tract_polyps2.41423947
5MP0003566_abnormal_cell_adhesion2.32496104
6MP0009840_abnormal_foam_cell2.07442067
7MP0006054_spinal_hemorrhage1.97644995
8MP0005360_urolithiasis1.95969778
9MP0005275_abnormal_skin_tensile1.93129355
10MP0010234_abnormal_vibrissa_follicle1.90921113
11MP0005451_abnormal_body_composition1.90141362
12MP0005023_abnormal_wound_healing1.85546099
13MP0003303_peritoneal_inflammation1.84100805
14MP0002877_abnormal_melanocyte_morpholog1.79848643
15MP0004947_skin_inflammation1.79611162
16MP0003436_decreased_susceptibility_to1.71352236
17MP0002139_abnormal_hepatobiliary_system1.70090572
18MP0005409_darkened_coat_color1.68602024
19MP0005076_abnormal_cell_differentiation1.66607946
20MP0002009_preneoplasia1.66586454
21MP0005058_abnormal_lysosome_morphology1.57746117
22MP0003828_pulmonary_edema1.56535849
23MP0000685_abnormal_immune_system1.55995862
24MP0003656_abnormal_erythrocyte_physiolo1.55748864
25MP0003279_aneurysm1.49651086
26MP0002933_joint_inflammation1.46960220
27MP0008260_abnormal_autophagy1.45493896
28MP0004782_abnormal_surfactant_physiolog1.42085112
29MP0003453_abnormal_keratinocyte_physiol1.40429791
30MP0002166_altered_tumor_susceptibility1.40225113
31MP0005501_abnormal_skin_physiology1.39277047
32MP0009278_abnormal_bone_marrow1.37642326
33MP0003252_abnormal_bile_duct1.37352594
34MP0003091_abnormal_cell_migration1.37243738
35MP0003191_abnormal_cellular_cholesterol1.36036879
36MP0009384_cardiac_valve_regurgitation1.34567437
37MP0003950_abnormal_plasma_membrane1.33761761
38MP0001958_emphysema1.33133367
39MP0001533_abnormal_skeleton_physiology1.31387353
40MP0004272_abnormal_basement_membrane1.30132258
41MP0010155_abnormal_intestine_physiology1.28691653
42MP0004233_abnormal_muscle_weight1.28582835
43MP0002060_abnormal_skin_morphology1.27213806
44MP0001849_ear_inflammation1.26507389
45MP0005083_abnormal_biliary_tract1.25931361
46MP0001790_abnormal_immune_system1.25874869
47MP0005387_immune_system_phenotype1.25874869
48MP0001348_abnormal_lacrimal_gland1.23128355
49MP0005365_abnormal_bile_salt1.20791257
50MP0003045_fibrosis1.20014853
51MP0010368_abnormal_lymphatic_system1.19172051
52MP0003941_abnormal_skin_development1.18469904
53MP0005464_abnormal_platelet_physiology1.18460100
54MP0004185_abnormal_adipocyte_glucose1.16172897
55MP0001666_abnormal_nutrient_absorption1.14092421
56MP0009333_abnormal_splenocyte_physiolog1.13450917
57MP0006082_CNS_inflammation1.12767010
58MP0004264_abnormal_extraembryonic_tissu1.12631176
59MP0002138_abnormal_hepatobiliary_system1.07939785
60MP0005621_abnormal_cell_physiology1.06998664
61MP0000609_abnormal_liver_physiology1.06994132
62MP0001873_stomach_inflammation1.06564957
63MP0001915_intracranial_hemorrhage1.06289231
64MP0002998_abnormal_bone_remodeling1.05391177
65MP0005165_increased_susceptibility_to1.04895330
66MP0000733_abnormal_muscle_development1.04638328
67MP0002419_abnormal_innate_immunity1.03696548
68MP0010678_abnormal_skin_adnexa1.03253296
69MP0000858_altered_metastatic_potential1.03138129
70MP0001835_abnormal_antigen_presentation1.01808528
71MP0003448_altered_tumor_morphology1.01119336
72MP0002168_other_aberrant_phenotype1.00978265
73MP0001243_abnormal_dermal_layer0.99719290
74MP0002405_respiratory_system_inflammati0.98481234
75MP0005000_abnormal_immune_tolerance0.98108616
76MP0003724_increased_susceptibility_to0.97308571
77MP0002254_reproductive_system_inflammat0.97212542
78MP0002452_abnormal_antigen_presenting0.97001933
79MP0005085_abnormal_gallbladder_physiolo0.95773468
80MP0005025_abnormal_response_to0.95709830
81MP0010329_abnormal_lipoprotein_level0.95668720
82MP0009643_abnormal_urine_homeostasis0.95411673
83MP0001800_abnormal_humoral_immune0.95186607
84MP0003221_abnormal_cardiomyocyte_apopto0.95123397
85MP0005257_abnormal_intraocular_pressure0.94973050
86MP0001845_abnormal_inflammatory_respons0.94644329
87MP0000465_gastrointestinal_hemorrhage0.94511915
88MP0005164_abnormal_response_to0.94320788
89MP0009785_altered_susceptibility_to0.93488197
90MP0002896_abnormal_bone_mineralization0.92180877
91MP0002006_tumorigenesis0.92028913
92MP0002796_impaired_skin_barrier0.90712080
93MP0001216_abnormal_epidermal_layer0.90308232
94MP0001853_heart_inflammation0.90251064
95MP0001545_abnormal_hematopoietic_system0.90211246
96MP0005397_hematopoietic_system_phenotyp0.90211246
97MP0003866_abnormal_defecation0.88841558
98MP0000003_abnormal_adipose_tissue0.88568188
99MP0003763_abnormal_thymus_physiology0.87001116
100MP0004808_abnormal_hematopoietic_stem0.86257805
101MP0003172_abnormal_lysosome_physiology0.85378494
102MP0005375_adipose_tissue_phenotype0.85024744
103MP0008875_abnormal_xenobiotic_pharmacok0.84987480
104MP0003795_abnormal_bone_structure0.84716721
105MP0002723_abnormal_immune_serum0.84324199
106MP0010307_abnormal_tumor_latency0.83913927
107MP0000767_abnormal_smooth_muscle0.83802719
108MP0003183_abnormal_peptide_metabolism0.82819994
109MP0001851_eye_inflammation0.82783319
110MP0001730_embryonic_growth_arrest0.82278681
111MP0002086_abnormal_extraembryonic_tissu0.82227195
112MP0000343_altered_response_to0.81350175
113MP0001819_abnormal_immune_cell0.80755149
114MP0002420_abnormal_adaptive_immunity0.80612658
115MP0000598_abnormal_liver_morphology0.80190091
116MP0000377_abnormal_hair_follicle0.79821341
117MP0000490_abnormal_crypts_of0.79736456
118MP0005666_abnormal_adipose_tissue0.79561942
119MP0008004_abnormal_stomach_pH0.79413499
120MP0005390_skeleton_phenotype0.78774780
121MP0004510_myositis0.78316161
122MP0003868_abnormal_feces_composition0.77336520
123MP0005671_abnormal_response_to0.76708569
124MP0002396_abnormal_hematopoietic_system0.76430762
125MP0005623_abnormal_meninges_morphology0.75849551
126MP0005166_decreased_susceptibility_to0.74907203
127MP0003075_altered_response_to0.74083785
128MP0009931_abnormal_skin_appearance0.73576281
129MP0000604_amyloidosis0.72373289
130MP0000681_abnormal_thyroid_gland0.72161978
131MP0004883_abnormal_blood_vessel0.71551897
132MP0003806_abnormal_nucleotide_metabolis0.70785088
133MP0000627_abnormal_mammary_gland0.70656518
134MP0000249_abnormal_blood_vessel0.70254653
135MP0009780_abnormal_chondrocyte_physiolo0.69518703
136MP0005384_cellular_phenotype0.68952183
137MP0002098_abnormal_vibrissa_morphology0.68574591
138MP0003984_embryonic_growth_retardation0.68251955
139MP0001191_abnormal_skin_condition0.67326838

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.97744169
2Premature rupture of membranes (HP:0001788)3.40978181
3Cerebral aneurysm (HP:0004944)3.16162240
4Aortic aneurysm (HP:0004942)2.96616280
5Peritonitis (HP:0002586)2.95108004
6Cervical subluxation (HP:0003308)2.85321117
7Osteolytic defects of the phalanges of the hand (HP:0009771)2.73813142
8Osteolytic defects of the hand bones (HP:0009699)2.73813142
9Atrophic scars (HP:0001075)2.72241702
10Myocardial infarction (HP:0001658)2.62731497
11Aortic dissection (HP:0002647)2.60751879
12Abnormality of glycolipid metabolism (HP:0010969)2.56115548
13Abnormality of liposaccharide metabolism (HP:0010968)2.56115548
14Abnormality of glycosphingolipid metabolism (HP:0004343)2.56115548
15Ankyloglossia (HP:0010296)2.54059115
16Deep venous thrombosis (HP:0002625)2.48276849
17Shallow orbits (HP:0000586)2.47911107
18Mucopolysacchariduria (HP:0008155)2.45617503
19Urinary glycosaminoglycan excretion (HP:0003541)2.45617503
20Syringomyelia (HP:0003396)2.45370498
21Spinal cord lesions (HP:0100561)2.45370498
22Interstitial pulmonary disease (HP:0006530)2.45234191
23Right ventricular cardiomyopathy (HP:0011663)2.44996012
24Eczematoid dermatitis (HP:0000976)2.44359835
25Ankle contracture (HP:0006466)2.42847259
26Xanthomatosis (HP:0000991)2.40695914
27Aneurysm (HP:0002617)2.29910610
28Dysostosis multiplex (HP:0000943)2.28337463
29Mitral valve prolapse (HP:0001634)2.26963731
30Dilatation of the ascending aorta (HP:0005111)2.25841881
31Thin bony cortex (HP:0002753)2.25652316
32Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24241339
33Abnormality of polysaccharide metabolism (HP:0011012)2.24241339
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24241339
35Abnormality of oral frenula (HP:0000190)2.23811878
36Flat acetabular roof (HP:0003180)2.23063788
37Esophageal varix (HP:0002040)2.22881403
38Vertebral compression fractures (HP:0002953)2.22701272
39Distal lower limb amyotrophy (HP:0008944)2.21619698
40Increased density of long bones (HP:0006392)2.19523949
41Insidious onset (HP:0003587)2.18626173
42Termporal pattern (HP:0011008)2.18626173
43Ulnar bowing (HP:0003031)2.15778128
44Absent frontal sinuses (HP:0002688)2.15551521
45Increased mean platelet volume (HP:0011877)2.14152502
46Broad metatarsal (HP:0001783)2.11467305
47Increased cerebral lipofuscin (HP:0011813)2.09713621
48Broad face (HP:0000283)2.09071143
49Abnormal platelet volume (HP:0011876)2.08182434
50Fragile skin (HP:0001030)2.06498546
51Upper limb amyotrophy (HP:0009129)2.06055268
52Distal upper limb amyotrophy (HP:0007149)2.06055268
53Vacuolated lymphocytes (HP:0001922)2.03543492
54Hematochezia (HP:0002573)2.00884755
55Blue sclerae (HP:0000592)2.00211947
56Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.99099548
57Abnormality of the common coagulation pathway (HP:0010990)1.98197835
58Abnormality of the peritoneum (HP:0002585)1.95097485
59Distal lower limb muscle weakness (HP:0009053)1.93880812
60Persistence of primary teeth (HP:0006335)1.91127111
61Spontaneous hematomas (HP:0007420)1.89606388
62Disproportionate tall stature (HP:0001519)1.89586274
63Centrally nucleated skeletal muscle fibers (HP:0003687)1.88839964
64Mitral stenosis (HP:0001718)1.88807385
65Spondylolisthesis (HP:0003302)1.88590296
66Increased connective tissue (HP:0009025)1.87241449
67Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.87147088
68Wormian bones (HP:0002645)1.86313803
69Coarse hair (HP:0002208)1.83700497
70Hand muscle atrophy (HP:0009130)1.83686738
71Abnormality of nail color (HP:0100643)1.82425701
72Vascular tortuosity (HP:0004948)1.81763556
73Spinal rigidity (HP:0003306)1.81465123
74Autoimmune thrombocytopenia (HP:0001973)1.81386588
75Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.79220775
76Abnormality of the acetabulum (HP:0003170)1.78811562
77Arterial tortuosity (HP:0005116)1.77937610
78Pustule (HP:0200039)1.77596254
79Radial bowing (HP:0002986)1.77312302
80Polycythemia (HP:0001901)1.77201102
81Ectopia lentis (HP:0001083)1.76832861
82Bowing of the arm (HP:0006488)1.76528113
83Bowed forearm bones (HP:0003956)1.76528113
84Abnormality of monocarboxylic acid metabolism (HP:0010996)1.76324333
85Subacute progressive viral hepatitis (HP:0006572)1.76242743
86Axonal loss (HP:0003447)1.75934121
87Cardiovascular calcification (HP:0011915)1.75734823
88Abnormality of the distal phalanges of the toes (HP:0010182)1.75321173
89Asymmetry of the thorax (HP:0001555)1.74793102
90Abdominal distention (HP:0003270)1.74530187
91Glucose intolerance (HP:0000833)1.73167078
92Abnormal foot bone ossification (HP:0010675)1.72193862
93Papillary thyroid carcinoma (HP:0002895)1.71037844
94Natal tooth (HP:0000695)1.70783533
95Hypoglycemic coma (HP:0001325)1.70704255
96Focal segmental glomerulosclerosis (HP:0000097)1.69935994
97Hyperacusis (HP:0010780)1.69899726
98Protuberant abdomen (HP:0001538)1.69724055
99Abnormality of glutamine family amino acid metabolism (HP:0010902)1.69659354
100Bone pain (HP:0002653)1.69580132
101Colitis (HP:0002583)1.68836945
102Increased neuronal autofluorescent lipopigment (HP:0002074)1.68624036
103Relative macrocephaly (HP:0004482)1.68616917
104Abnormal platelet function (HP:0011869)1.68251549
105Impaired platelet aggregation (HP:0003540)1.68251549
106Fatigue (HP:0012378)1.68178505
107Cellulitis (HP:0100658)1.68046734
108Milia (HP:0001056)1.68003967
109Genu recurvatum (HP:0002816)1.67981475
110Tetraparesis (HP:0002273)1.67851443
111Thoracolumbar scoliosis (HP:0002944)1.67460812
112Loss of speech (HP:0002371)1.67373612
113Hydroxyprolinuria (HP:0003080)1.67210807
114Abnormality of proline metabolism (HP:0010907)1.67210807
115Back pain (HP:0003418)1.67150513
116Intrahepatic cholestasis (HP:0001406)1.66878049
117Increased IgE level (HP:0003212)1.66302636
118Curly hair (HP:0002212)1.65710280
119Advanced eruption of teeth (HP:0006288)1.65661629
120Cupped ribs (HP:0000887)1.65373732
121Myositis (HP:0100614)1.64966021
122Malnutrition (HP:0004395)1.64790855
123Abnormality of skull ossification (HP:0002703)1.64574733
124Achilles tendon contracture (HP:0001771)1.64077794
125Mildly elevated creatine phosphokinase (HP:0008180)1.62851854
126Gingivitis (HP:0000230)1.62468024
127Complement deficiency (HP:0004431)1.61922815
128Beaking of vertebral bodies (HP:0004568)1.61794623
129Abnormality of the nasal mucosa (HP:0000433)1.61509517
130Short nail (HP:0001799)1.61202429
131Abnormality of the distal phalanx of the thumb (HP:0009617)1.61040613
132Abnormality of macrophages (HP:0004311)1.61005489
133Hyporeflexia of lower limbs (HP:0002600)1.60978783
134Rectal prolapse (HP:0002035)1.60869830
135Striae distensae (HP:0001065)1.59834179
136Nonimmune hydrops fetalis (HP:0001790)1.59473348
137Joint laxity (HP:0001388)1.59193423
138Deep philtrum (HP:0002002)1.58640264
139Chronic otitis media (HP:0000389)1.58457097
140Nephritis (HP:0000123)1.58391846
141Severe short stature (HP:0003510)1.58216512
142Asymmetric septal hypertrophy (HP:0001670)1.58077501
143Ovoid vertebral bodies (HP:0003300)1.57986813
144Bladder diverticulum (HP:0000015)1.56293652
145Periodontitis (HP:0000704)1.55368889
146Orthostatic hypotension (HP:0001278)1.54164895
147Abnormal glucose tolerance (HP:0001952)1.52618679
148Increased variability in muscle fiber diameter (HP:0003557)1.52602605
149Spinal cord compression (HP:0002176)1.52507168
150Acute myeloid leukemia (HP:0004808)1.52437451
151Abnormality of skeletal muscle fiber size (HP:0012084)1.49246622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.93278017
2ERN13.69966373
3PKN22.80051749
4PRPF4B2.61682507
5EPHB12.46830715
6EEF2K2.38355891
7IRAK32.17820617
8STK102.16005390
9SIK12.15034166
10PTK62.12417608
11TTN2.08097208
12MAP4K12.01821724
13ICK1.97059903
14LRRK21.95605831
15MAP3K101.94584784
16FGFR41.94036918
17KSR21.76143222
18SMG11.68605621
19RIPK11.68597780
20TAOK31.67932486
21RIPK41.65990821
22LATS11.61912565
23MAP3K131.54302821
24JAK31.51541672
25TGFBR21.46901782
26TYK21.45875127
27PDGFRA1.45208304
28CDK121.42617699
29MAP3K61.41834265
30PTK21.39963344
31RPS6KA41.36065695
32ZAP701.35724275
33TBK11.33674154
34CDK61.30417663
35BMPR21.30353808
36JAK11.28337677
37SCYL21.27804885
38BMX1.26501983
39LMTK21.26441124
40EPHA31.23215163
41YES11.22983093
42EIF2AK11.21485211
43EPHA21.21130926
44FLT31.19408062
45LATS21.18204345
46ITK1.16117612
47NEK91.14875685
48KDR1.08966703
49MAP3K31.07675872
50CSK1.05875321
51MAP2K31.05809658
52PAK41.05634964
53TESK11.04309562
54TRPM71.03269980
55MET1.01880403
56DMPK0.99945803
57PAK20.99786495
58CAMK1D0.99756909
59STK30.99716099
60NME20.98195687
61TESK20.97227243
62FGFR30.94152788
63DDR20.93412896
64PDGFRB0.90822805
65FRK0.89652218
66MTOR0.87995814
67DYRK1B0.85461446
68MST40.85245028
69CDC42BPA0.85088934
70BTK0.84550425
71CLK10.84334244
72EIF2AK30.83234478
73TAOK10.81231386
74MYLK0.80820806
75MAP2K20.79503319
76MAP3K80.79232777
77MAP3K20.79127691
78JAK20.78493994
79MST1R0.78281136
80STK240.77822165
81HCK0.76671741
82BLK0.75338710
83BRD40.74538192
84MAPKAPK30.73627490
85HIPK20.72342388
86CHUK0.71376042
87KIT0.70707332
88TTK0.70355558
89SIK30.69382881
90CAMK1G0.68010695
91FER0.67354928
92RPS6KB20.66780867
93STK380.66582950
94PIK3CG0.66285916
95PRKG20.66059850
96RET0.65848672
97PBK0.65360977
98ERBB30.64635750
99KSR10.64602675
100MAP3K70.64236303
101PDPK10.63192890
102MAP3K120.61485012
103MAP3K110.61279505
104RAF10.61065634
105MAP3K10.60290169
106TGFBR10.59135849
107PIM20.57684231
108NTRK10.57634625
109LCK0.57519597
110IKBKE0.56949695
111GRK60.56054612
112CSF1R0.55606046
113NEK60.55171167
114FGFR10.54990166
115MAP3K140.54476887
116ALK0.53088854
117TAOK20.52790865
118PIM10.51647550
119PRKD10.51477734
120PRKCH0.51197364
121MOS0.51168904
122RPS6KA20.51107211
123NLK0.49247412
124EGFR0.48811057
125MAPKAPK20.47871878
126CDK40.47019429
127IKBKB0.46976990
128PAK30.44200355
129GSK3A0.43779540
130ERBB40.43773220
131CDK90.41975273
132EPHB20.41940669
133AKT30.41834652
134BCKDK0.41302872
135LIMK10.40576363
136MAPK110.40525322
137ABL20.39481847
138NEK10.39292990
139MARK20.38447802

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009101.97703327
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.76030594
3Caffeine metabolism_Homo sapiens_hsa002321.73346308
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.63985559
5Leukocyte transendothelial migration_Homo sapiens_hsa046701.60525241
6Staphylococcus aureus infection_Homo sapiens_hsa051501.55129751
7ECM-receptor interaction_Homo sapiens_hsa045121.54469748
8Leishmaniasis_Homo sapiens_hsa051401.52379277
9Small cell lung cancer_Homo sapiens_hsa052221.51498720
10Chronic myeloid leukemia_Homo sapiens_hsa052201.50678562
11Toxoplasmosis_Homo sapiens_hsa051451.47997350
12Focal adhesion_Homo sapiens_hsa045101.42806533
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42232532
14Osteoclast differentiation_Homo sapiens_hsa043801.39870495
15Amoebiasis_Homo sapiens_hsa051461.32924497
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28560164
17Adherens junction_Homo sapiens_hsa045201.27922996
18Antigen processing and presentation_Homo sapiens_hsa046121.26625545
19Lysosome_Homo sapiens_hsa041421.26588593
20Proteoglycans in cancer_Homo sapiens_hsa052051.26416590
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26235551
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.26212835
23Complement and coagulation cascades_Homo sapiens_hsa046101.25581825
24Endometrial cancer_Homo sapiens_hsa052131.22915078
25Fat digestion and absorption_Homo sapiens_hsa049751.15695780
26Shigellosis_Homo sapiens_hsa051311.14639049
27Pancreatic cancer_Homo sapiens_hsa052121.13466048
28Bladder cancer_Homo sapiens_hsa052191.12533154
29B cell receptor signaling pathway_Homo sapiens_hsa046621.12462408
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.12219811
31Pentose phosphate pathway_Homo sapiens_hsa000301.12095604
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11416764
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11049710
34Fatty acid degradation_Homo sapiens_hsa000711.10351925
35Insulin resistance_Homo sapiens_hsa049311.09791035
36Lysine degradation_Homo sapiens_hsa003101.09193866
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.08461641
38Sphingolipid metabolism_Homo sapiens_hsa006001.08123649
39Selenocompound metabolism_Homo sapiens_hsa004501.07518260
40Acute myeloid leukemia_Homo sapiens_hsa052211.06269507
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.05546609
42Tryptophan metabolism_Homo sapiens_hsa003801.03301142
43Malaria_Homo sapiens_hsa051441.02646100
44Viral myocarditis_Homo sapiens_hsa054161.02453432
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01713711
46Measles_Homo sapiens_hsa051621.01686790
47Galactose metabolism_Homo sapiens_hsa000521.00993058
48Apoptosis_Homo sapiens_hsa042101.00551373
49PPAR signaling pathway_Homo sapiens_hsa033200.99502297
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99291184
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97100220
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97089726
53ErbB signaling pathway_Homo sapiens_hsa040120.96088786
54Prion diseases_Homo sapiens_hsa050200.95747351
55Other glycan degradation_Homo sapiens_hsa005110.94823749
56Inositol phosphate metabolism_Homo sapiens_hsa005620.94611452
57Sulfur metabolism_Homo sapiens_hsa009200.92514742
58Platelet activation_Homo sapiens_hsa046110.91622455
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.91548277
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91067744
61TNF signaling pathway_Homo sapiens_hsa046680.90932025
62Choline metabolism in cancer_Homo sapiens_hsa052310.90791802
63Arginine biosynthesis_Homo sapiens_hsa002200.90301871
64Hepatitis B_Homo sapiens_hsa051610.89857918
65Pertussis_Homo sapiens_hsa051330.89142462
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89020528
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88958440
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86978161
69MicroRNAs in cancer_Homo sapiens_hsa052060.86903506
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86288876
71Glioma_Homo sapiens_hsa052140.86185344
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.84816213
73Insulin signaling pathway_Homo sapiens_hsa049100.83707089
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83566722
75Legionellosis_Homo sapiens_hsa051340.83047621
76Fructose and mannose metabolism_Homo sapiens_hsa000510.82888089
77Starch and sucrose metabolism_Homo sapiens_hsa005000.82677721
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.80970682
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79974816
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79495292
81Tuberculosis_Homo sapiens_hsa051520.79493746
82Histidine metabolism_Homo sapiens_hsa003400.77992636
83Phagosome_Homo sapiens_hsa041450.77572363
84Protein digestion and absorption_Homo sapiens_hsa049740.77124475
85T cell receptor signaling pathway_Homo sapiens_hsa046600.76590369
86Prostate cancer_Homo sapiens_hsa052150.75935297
87Renin-angiotensin system_Homo sapiens_hsa046140.75547094
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73820984
89Hepatitis C_Homo sapiens_hsa051600.73506763
90Hematopoietic cell lineage_Homo sapiens_hsa046400.73045185
91Primary immunodeficiency_Homo sapiens_hsa053400.72782677
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72673992
93Bile secretion_Homo sapiens_hsa049760.72102692
94Prolactin signaling pathway_Homo sapiens_hsa049170.71019234
95VEGF signaling pathway_Homo sapiens_hsa043700.69799663
96Vibrio cholerae infection_Homo sapiens_hsa051100.69771407
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67280652
98Salmonella infection_Homo sapiens_hsa051320.67175736
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65696538
100Renal cell carcinoma_Homo sapiens_hsa052110.65369092
101Estrogen signaling pathway_Homo sapiens_hsa049150.64805214
102Thyroid cancer_Homo sapiens_hsa052160.64425085
103Herpes simplex infection_Homo sapiens_hsa051680.64295129
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64109025
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.64107819
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.63984243
107ABC transporters_Homo sapiens_hsa020100.63944922
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63186352
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62838427
110GnRH signaling pathway_Homo sapiens_hsa049120.61258279
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60121794
112Influenza A_Homo sapiens_hsa051640.59746566
113Fatty acid metabolism_Homo sapiens_hsa012120.57928360
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.57780548
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57623975
116Notch signaling pathway_Homo sapiens_hsa043300.57202257
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.55806176
118Carbon metabolism_Homo sapiens_hsa012000.55609394
119* Endocytosis_Homo sapiens_hsa041440.55384789
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54760042
121Non-small cell lung cancer_Homo sapiens_hsa052230.54529740
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54484202
123mTOR signaling pathway_Homo sapiens_hsa041500.54432712
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.53981750
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53786233
126Viral carcinogenesis_Homo sapiens_hsa052030.53744449
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51968025
128HIF-1 signaling pathway_Homo sapiens_hsa040660.51567919
129Phenylalanine metabolism_Homo sapiens_hsa003600.50612312
130Colorectal cancer_Homo sapiens_hsa052100.49188029
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48404566
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47997859
133Chemokine signaling pathway_Homo sapiens_hsa040620.47638772

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