ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.30398012
2	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.25110677
3	DNA deamination (GO:0045006)	4.02358346
4	L-fucose catabolic process (GO:0042355)	3.98864457
5	fucose catabolic process (GO:0019317)	3.98864457
6	L-fucose metabolic process (GO:0042354)	3.98864457
7	indole-containing compound catabolic process (GO:0042436)	3.77285827
8	indolalkylamine catabolic process (GO:0046218)	3.77285827
9	tryptophan catabolic process (GO:0006569)	3.77285827
10	protein-cofactor linkage (GO:0018065)	3.70583161
11	response to pheromone (GO:0019236)	3.67964324
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.62657530
13	NADH dehydrogenase complex assembly (GO:0010257)	3.62657530
14	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.62657530
15	protein complex biogenesis (GO:0070271)	3.61246874
16	protein K11-linked deubiquitination (GO:0035871)	3.55731827
17	piRNA metabolic process (GO:0034587)	3.54083359
18	indolalkylamine metabolic process (GO:0006586)	3.50255196
19	positive regulation of prostaglandin secretion (GO:0032308)	3.48547942
20	cellular ketone body metabolic process (GO:0046950)	3.41731431
21	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.40575537
22	mitochondrial respiratory chain complex assembly (GO:0033108)	3.36205821
23	kynurenine metabolic process (GO:0070189)	3.35007860
24	respiratory chain complex IV assembly (GO:0008535)	3.29965368
25	detection of light stimulus involved in visual perception (GO:0050908)	3.29032543
26	detection of light stimulus involved in sensory perception (GO:0050962)	3.29032543
27	tryptophan metabolic process (GO:0006568)	3.23687427
28	positive regulation of fatty acid transport (GO:2000193)	3.12188495
29	reflex (GO:0060004)	3.12003203
30	primary amino compound metabolic process (GO:1901160)	3.08264651
31	ketone body metabolic process (GO:1902224)	3.07410990
32	negative regulation of telomere maintenance (GO:0032205)	3.05754773
33	regulation of appetite (GO:0032098)	3.01569678
34	neural tube formation (GO:0001841)	2.99103448
35	water-soluble vitamin biosynthetic process (GO:0042364)	2.98042343
36	platelet dense granule organization (GO:0060155)	2.95179095
37	cytochrome complex assembly (GO:0017004)	2.94921313
38	gamma-aminobutyric acid transport (GO:0015812)	2.91850058
39	sulfation (GO:0051923)	2.91265210
40	negative regulation of mast cell activation (GO:0033004)	2.90265602
41	replication fork processing (GO:0031297)	2.89749682
42	DNA methylation involved in gamete generation (GO:0043046)	2.88525167
43	protein neddylation (GO:0045116)	2.86966391
44	indole-containing compound metabolic process (GO:0042430)	2.86890903
45	behavioral response to ethanol (GO:0048149)	2.86825963
46	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.86701513
47	regulation of cilium movement (GO:0003352)	2.83129900
48	DNA double-strand break processing (GO:0000729)	2.82310935
49	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.80951917
50	anterograde synaptic vesicle transport (GO:0048490)	2.80805055
51	regulation of glucokinase activity (GO:0033131)	2.80459903
52	regulation of hexokinase activity (GO:1903299)	2.80459903
53	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.78691986
54	ATP synthesis coupled proton transport (GO:0015986)	2.78691986
55	preassembly of GPI anchor in ER membrane (GO:0016254)	2.78591975
56	positive regulation of icosanoid secretion (GO:0032305)	2.78312424
57	serotonin receptor signaling pathway (GO:0007210)	2.78302739
58	protein polyglutamylation (GO:0018095)	2.78192734
59	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.76221257
60	synapsis (GO:0007129)	2.75730916
61	amine catabolic process (GO:0009310)	2.74612420
62	cellular biogenic amine catabolic process (GO:0042402)	2.74612420
63	nonmotile primary cilium assembly (GO:0035058)	2.73372458
64	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.72579831
65	neuronal action potential (GO:0019228)	2.71186847
66	regulation of action potential (GO:0098900)	2.71181371
67	axoneme assembly (GO:0035082)	2.70966824
68	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.70917661
69	regulation of prostaglandin secretion (GO:0032306)	2.67399795
70	mannosylation (GO:0097502)	2.67019675
71	epithelial cilium movement (GO:0003351)	2.66978298
72	dopamine transport (GO:0015872)	2.65903266
73	glycerophospholipid catabolic process (GO:0046475)	2.64765917
74	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.64667376
75	male meiosis I (GO:0007141)	2.63326060
76	rhodopsin mediated signaling pathway (GO:0016056)	2.60940895
77	retinal cone cell development (GO:0046549)	2.60169551
78	pseudouridine synthesis (GO:0001522)	2.58563765
79	serotonin metabolic process (GO:0042428)	2.57717732
80	ubiquinone biosynthetic process (GO:0006744)	2.57714611
81	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.54879111
82	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.54184518
83	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.53778918
84	photoreceptor cell maintenance (GO:0045494)	2.52139158
85	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.50770771
86	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.50523655
87	male meiosis (GO:0007140)	2.50077364
88	metallo-sulfur cluster assembly (GO:0031163)	2.49524045
89	iron-sulfur cluster assembly (GO:0016226)	2.49524045
90	regulation of meiosis I (GO:0060631)	2.49329980
91	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.49305496
92	protein K6-linked ubiquitination (GO:0085020)	2.48194281
93	ubiquinone metabolic process (GO:0006743)	2.47530978
94	cilium morphogenesis (GO:0060271)	2.47162181
95	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.46767554
96	rRNA catabolic process (GO:0016075)	2.45414783
97	reciprocal DNA recombination (GO:0035825)	2.43330284
98	reciprocal meiotic recombination (GO:0007131)	2.43330284
99	benzene-containing compound metabolic process (GO:0042537)	2.42200894
100	L-methionine biosynthetic process (GO:0071265)	2.40593450

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.88512537
2	VDR_22108803_ChIP-Seq_LS180_Human	3.34529045
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.09089522
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.94779978
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.65903901
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.52078956
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.50714355
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44700180
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.41288980
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.34844401
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.33862687
12	EWS_26573619_Chip-Seq_HEK293_Human	2.14101141
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08813769
14	FUS_26573619_Chip-Seq_HEK293_Human	2.08406563
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03141606
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.01949995
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.99236299
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.98076415
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.91497556
20	P300_19829295_ChIP-Seq_ESCs_Human	1.91317599
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.89043634
22	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.82781648
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.81760834
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.77099853
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.73222250
26	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.61958189
27	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.60001471
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57550849
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.54987436
30	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.51936437
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.51408719
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48469262
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46263745
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.46038307
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.46038307
36	AR_25329375_ChIP-Seq_VCAP_Human	1.45321471
37	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.44928915
38	REST_21632747_ChIP-Seq_MESCs_Mouse	1.44874047
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.43563977
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41084994
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.41084994
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.40521188
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.38747040
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37982245
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37982245
46	STAT3_23295773_ChIP-Seq_U87_Human	1.37345366
47	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.35487403
48	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.35003316
49	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.33156679
50	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.33019439
51	TCF4_23295773_ChIP-Seq_U87_Human	1.32252414
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.31883653
53	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.30963255
54	VDR_23849224_ChIP-Seq_CD4+_Human	1.30698714
55	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28924709
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27936096
57	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26936506
58	NCOR_22424771_ChIP-Seq_293T_Human	1.26900155
59	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26658662
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25917718
61	RNF2_27304074_Chip-Seq_NSC_Mouse	1.25430020
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.24413296
63	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.24000714
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.19983354
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.18600695
66	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.18439331
67	AR_20517297_ChIP-Seq_VCAP_Human	1.18058612
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.17784577
69	ELK1_19687146_ChIP-ChIP_HELA_Human	1.17289630
70	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16793591
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16774253
72	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.15978160
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15012344
74	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.14367851
75	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14367851
76	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13986819
77	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.13942162
78	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13774462
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13518001
80	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.13446303
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12654103
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09031570
83	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08936063
84	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06590186
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06345810
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05943271
87	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05741549
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05062900
89	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02074469
90	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.01070216
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00669775
92	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.00661299
93	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.00100913
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99046231
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98893465
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.98237917
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.97956610
98	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.97814343
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97400060
100	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.96831393

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.12291896
2	MP0008877_abnormal_DNA_methylation	2.95400355
3	MP0003195_calcinosis	2.83944169
4	MP0001968_abnormal_touch/_nociception	2.65106911
5	MP0005551_abnormal_eye_electrophysiolog	2.37924181
6	MP0002837_dystrophic_cardiac_calcinosis	2.27670730
7	MP0005646_abnormal_pituitary_gland	2.09271522
8	MP0009046_muscle_twitch	2.04346409
9	MP0003787_abnormal_imprinting	2.03532722
10	MP0009745_abnormal_behavioral_response	2.01860510
11	MP0008875_abnormal_xenobiotic_pharmacok	2.01407046
12	MP0004147_increased_porphyrin_level	1.98929618
13	MP0005645_abnormal_hypothalamus_physiol	1.97576105
14	MP0006072_abnormal_retinal_apoptosis	1.94613120
15	MP0002736_abnormal_nociception_after	1.93604940
16	MP0006292_abnormal_olfactory_placode	1.85584061
17	MP0006276_abnormal_autonomic_nervous	1.85532605
18	MP0002638_abnormal_pupillary_reflex	1.80837997
19	MP0004142_abnormal_muscle_tone	1.79758207
20	MP0004043_abnormal_pH_regulation	1.79175369
21	MP0003880_abnormal_central_pattern	1.76686500
22	MP0008872_abnormal_physiological_respon	1.76479527
23	MP0000372_irregular_coat_pigmentation	1.73053718
24	MP0002735_abnormal_chemical_nociception	1.70520692
25	MP0005253_abnormal_eye_physiology	1.69263937
26	MP0005084_abnormal_gallbladder_morpholo	1.69060848
27	MP0002272_abnormal_nervous_system	1.68902230
28	MP0001986_abnormal_taste_sensitivity	1.68380671
29	MP0003136_yellow_coat_color	1.63581510
30	MP0003011_delayed_dark_adaptation	1.61826007
31	MP0004885_abnormal_endolymph	1.60224459
32	MP0000569_abnormal_digit_pigmentation	1.57442471
33	MP0001485_abnormal_pinna_reflex	1.54226065
34	MP0002876_abnormal_thyroid_physiology	1.53606548
35	MP0001984_abnormal_olfaction	1.52626533
36	MP0001501_abnormal_sleep_pattern	1.51459946
37	MP0003646_muscle_fatigue	1.50355861
38	MP0000631_abnormal_neuroendocrine_gland	1.48198413
39	MP0002938_white_spotting	1.47305368
40	MP0003718_maternal_effect	1.46656276
41	MP0002653_abnormal_ependyma_morphology	1.45354684
42	MP0002064_seizures	1.43621590
43	MP0001486_abnormal_startle_reflex	1.41762092
44	MP0010386_abnormal_urinary_bladder	1.40642835
45	MP0002160_abnormal_reproductive_system	1.39551519
46	MP0002572_abnormal_emotion/affect_behav	1.37373794
47	MP0001905_abnormal_dopamine_level	1.37132562
48	MP0005389_reproductive_system_phenotype	1.33243344
49	MP0002733_abnormal_thermal_nociception	1.31509972
50	MP0001529_abnormal_vocalization	1.30242643
51	MP0008058_abnormal_DNA_repair	1.29681358
52	MP0001970_abnormal_pain_threshold	1.28301709
53	MP0005174_abnormal_tail_pigmentation	1.26017316
54	MP0002909_abnormal_adrenal_gland	1.22945456
55	MP0002557_abnormal_social/conspecific_i	1.21313271
56	MP0004133_heterotaxia	1.17322265
57	MP0005386_behavior/neurological_phenoty	1.17170920
58	MP0004924_abnormal_behavior	1.17170920
59	MP0002234_abnormal_pharynx_morphology	1.14429129
60	MP0002163_abnormal_gland_morphology	1.13607635
61	MP0005410_abnormal_fertilization	1.12442820
62	MP0004742_abnormal_vestibular_system	1.12186244
63	MP0000427_abnormal_hair_cycle	1.10562255
64	MP0002138_abnormal_hepatobiliary_system	1.09556268
65	MP0002928_abnormal_bile_duct	1.08968550
66	MP0001764_abnormal_homeostasis	1.07810377
67	MP0002067_abnormal_sensory_capabilities	1.06036435
68	MP0005379_endocrine/exocrine_gland_phen	1.03425023
69	MP0003635_abnormal_synaptic_transmissio	1.01656740
70	MP0002734_abnormal_mechanical_nocicepti	1.01326832
71	MP0003698_abnormal_male_reproductive	1.00561178
72	MP0005075_abnormal_melanosome_morpholog	0.99095075
73	MP0000230_abnormal_systemic_arterial	0.98200327
74	MP0003121_genomic_imprinting	0.97958867
75	MP0001919_abnormal_reproductive_system	0.95903090
76	MP0002063_abnormal_learning/memory/cond	0.95742059
77	MP0003122_maternal_imprinting	0.92294981
78	MP0005085_abnormal_gallbladder_physiolo	0.91079803
79	MP0002095_abnormal_skin_pigmentation	0.90651977
80	MP0001929_abnormal_gametogenesis	0.90146672
81	MP0003806_abnormal_nucleotide_metabolis	0.88976864
82	MP0004145_abnormal_muscle_electrophysio	0.88077017
83	MP0002822_catalepsy	0.87199372
84	MP0005332_abnormal_amino_acid	0.86666716
85	MP0002277_abnormal_respiratory_mucosa	0.86407692
86	MP0002210_abnormal_sex_determination	0.85242009
87	MP0003137_abnormal_impulse_conducting	0.85049077
88	MP0008995_early_reproductive_senescence	0.84586227
89	MP0004215_abnormal_myocardial_fiber	0.83433924
90	MP0002229_neurodegeneration	0.82461553
91	MP0005195_abnormal_posterior_eye	0.82322930
92	MP0008789_abnormal_olfactory_epithelium	0.80963130
93	MP0005167_abnormal_blood-brain_barrier	0.80605921
94	MP0001440_abnormal_grooming_behavior	0.79156674
95	MP0000026_abnormal_inner_ear	0.78802365
96	MP0000653_abnormal_sex_gland	0.77806484
97	MP0010329_abnormal_lipoprotein_level	0.76855942
98	MP0002752_abnormal_somatic_nervous	0.76452473
99	MP0006036_abnormal_mitochondrial_physio	0.75936915
100	MP0005448_abnormal_energy_balance	0.75848453

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.34887043
2	Pancreatic fibrosis (HP:0100732)	4.06181439
3	True hermaphroditism (HP:0010459)	3.90374848
4	Molar tooth sign on MRI (HP:0002419)	3.89847804
5	Abnormality of midbrain morphology (HP:0002418)	3.89847804
6	Congenital stationary night blindness (HP:0007642)	3.70033536
7	Nephronophthisis (HP:0000090)	3.27533368
8	Abnormality of the renal cortex (HP:0011035)	3.12122435
9	Abolished electroretinogram (ERG) (HP:0000550)	3.06645935
10	Medial flaring of the eyebrow (HP:0010747)	2.97868978
11	Attenuation of retinal blood vessels (HP:0007843)	2.93664690
12	Type II lissencephaly (HP:0007260)	2.92319914
13	Polydipsia (HP:0001959)	2.88241970
14	Abnormal drinking behavior (HP:0030082)	2.88241970
15	Abnormality of the renal medulla (HP:0100957)	2.80952453
16	Acute necrotizing encephalopathy (HP:0006965)	2.79212133
17	Chronic hepatic failure (HP:0100626)	2.75990763
18	Hyperventilation (HP:0002883)	2.73784788
19	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.66993660
20	Abnormality of alanine metabolism (HP:0010916)	2.66993660
21	Hyperalaninemia (HP:0003348)	2.66993660
22	Mitochondrial inheritance (HP:0001427)	2.63349568
23	Increased CSF lactate (HP:0002490)	2.59127835
24	Cystic liver disease (HP:0006706)	2.57599977
25	Renal cortical cysts (HP:0000803)	2.56331879
26	Acute encephalopathy (HP:0006846)	2.55857437
27	Hepatocellular necrosis (HP:0001404)	2.47296787
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.46075103
29	Hepatic necrosis (HP:0002605)	2.45597397
30	Progressive macrocephaly (HP:0004481)	2.44868712
31	Abnormal biliary tract physiology (HP:0012439)	2.41349379
32	Bile duct proliferation (HP:0001408)	2.41349379
33	Abnormal mitochondria in muscle tissue (HP:0008316)	2.39071670
34	Gait imbalance (HP:0002141)	2.38176263
35	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.36842434
36	Hypothermia (HP:0002045)	2.36169413
37	Sclerocornea (HP:0000647)	2.32388433
38	Congenital primary aphakia (HP:0007707)	2.31667197
39	Inability to walk (HP:0002540)	2.26705149
40	Pendular nystagmus (HP:0012043)	2.25913710
41	3-Methylglutaconic aciduria (HP:0003535)	2.25345304
42	Gaze-evoked nystagmus (HP:0000640)	2.24782175
43	Polyuria (HP:0000103)	2.23571271
44	Decreased circulating renin level (HP:0003351)	2.23423911
45	Tubular atrophy (HP:0000092)	2.22580940
46	Nephrogenic diabetes insipidus (HP:0009806)	2.21032022
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.18704751
48	Decreased central vision (HP:0007663)	2.17279486
49	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.14725494
50	Male pseudohermaphroditism (HP:0000037)	2.12625615
51	Large for gestational age (HP:0001520)	2.11158898
52	Bony spicule pigmentary retinopathy (HP:0007737)	2.09413900
53	Abnormality of the labia minora (HP:0012880)	2.08782056
54	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.07132709
55	Genital tract atresia (HP:0001827)	2.06870841
56	Lipid accumulation in hepatocytes (HP:0006561)	2.06030395
57	Anencephaly (HP:0002323)	2.03369628
58	Methylmalonic acidemia (HP:0002912)	2.02874924
59	Febrile seizures (HP:0002373)	2.01909491
60	Furrowed tongue (HP:0000221)	2.01826778
61	Lissencephaly (HP:0001339)	2.01710012
62	Cerebellar dysplasia (HP:0007033)	1.98986782
63	Focal motor seizures (HP:0011153)	1.96485640
64	Congenital sensorineural hearing impairment (HP:0008527)	1.96452977
65	Congenital hepatic fibrosis (HP:0002612)	1.95082033
66	Vaginal atresia (HP:0000148)	1.94356069
67	Optic disc pallor (HP:0000543)	1.91210975
68	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.90821200
69	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.90711348
70	Absent/shortened dynein arms (HP:0200106)	1.90711348
71	Renal Fanconi syndrome (HP:0001994)	1.89953747
72	Congenital, generalized hypertrichosis (HP:0004540)	1.89493844
73	Increased hepatocellular lipid droplets (HP:0006565)	1.89079232
74	Progressive inability to walk (HP:0002505)	1.88934434
75	Short tibia (HP:0005736)	1.86368460
76	Hyperglycinemia (HP:0002154)	1.85680821
77	Stomach cancer (HP:0012126)	1.85507635
78	Hypoglycemic seizures (HP:0002173)	1.83274681
79	Ketoacidosis (HP:0001993)	1.83091391
80	Methylmalonic aciduria (HP:0012120)	1.82096824
81	Keratoconus (HP:0000563)	1.81650057
82	Increased corneal curvature (HP:0100692)	1.81650057
83	Hypomagnesemia (HP:0002917)	1.80845246
84	Increased serum lactate (HP:0002151)	1.79931443
85	Ketosis (HP:0001946)	1.78226300
86	Optic nerve hypoplasia (HP:0000609)	1.75594139
87	Postaxial foot polydactyly (HP:0001830)	1.75170085
88	Severe muscular hypotonia (HP:0006829)	1.75130635
89	Abnormality of urine glucose concentration (HP:0011016)	1.75021203
90	Glycosuria (HP:0003076)	1.75021203
91	Generalized aminoaciduria (HP:0002909)	1.74808718
92	Abnormal urine output (HP:0012590)	1.72812938
93	Hemiparesis (HP:0001269)	1.72299189
94	Asplenia (HP:0001746)	1.71821168
95	Intestinal atresia (HP:0011100)	1.71768502
96	Progressive cerebellar ataxia (HP:0002073)	1.71355955
97	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.69941433
98	Abnormal number of erythroid precursors (HP:0012131)	1.69745541
99	Abnormal respiratory epithelium morphology (HP:0012253)	1.69712142
100	Abnormal respiratory motile cilium morphology (HP:0005938)	1.69712142

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.52955611
2	ADRBK2	3.61872831
3	WNK3	3.05483161
4	BMPR1B	2.80707777
5	ZAK	2.72484236
6	TLK1	2.63989949
7	MAP4K2	2.61286882
8	NUAK1	2.54911709
9	GRK1	2.44714640
10	PINK1	2.42157719
11	WNK4	2.27910245
12	INSRR	1.98280206
13	ACVR1B	1.98037628
14	TAOK3	1.90594042
15	TRIM28	1.89904133
16	MAPK13	1.78160660
17	DAPK2	1.68969157
18	STK39	1.66708862
19	NTRK3	1.64590448
20	CASK	1.63968456
21	OXSR1	1.50344918
22	BCKDK	1.43733641
23	PNCK	1.40980844
24	TXK	1.36709413
25	MKNK2	1.22514717
26	TNIK	1.18764231
27	DYRK2	1.15311305
28	ADRBK1	1.12421452
29	STK16	1.05163686
30	VRK1	0.99009660
31	PAK3	0.96035210
32	TEC	0.95827243
33	MST4	0.95522796
34	MAP3K4	0.93614818
35	PRKCG	0.90842608
36	PLK2	0.89229448
37	PRKCE	0.84809636
38	MKNK1	0.84679447
39	PLK4	0.83528836
40	TIE1	0.81157916
41	CSNK1G2	0.80246547
42	FGFR2	0.78413388
43	MAP2K7	0.78207134
44	CSNK1G1	0.77167753
45	CSNK1G3	0.75702701
46	TGFBR1	0.74923738
47	RPS6KA5	0.74292394
48	VRK2	0.74160244
49	EPHA4	0.72556890
50	EIF2AK3	0.72466835
51	MARK1	0.69650428
52	CAMKK2	0.67636943
53	FLT3	0.66949336
54	KIT	0.66592282
55	MAPKAPK5	0.65755062
56	PHKG1	0.64281143
57	PHKG2	0.64281143
58	SIK2	0.61957915
59	PTK2B	0.61434048
60	IKBKB	0.60559076
61	PIK3CA	0.58657108
62	ERBB3	0.58435001
63	TNK2	0.57535353
64	PRKCQ	0.55789373
65	BRSK2	0.54534348
66	CAMK2A	0.54375977
67	CSNK1A1L	0.53605755
68	PKN1	0.52741766
69	MUSK	0.52696073
70	PRKACA	0.50737322
71	MAPK15	0.48768800
72	PLK3	0.48518831
73	STK38L	0.47682765
74	NME1	0.47030479
75	MAPKAPK3	0.45923912
76	IRAK1	0.45811878
77	BCR	0.43947313
78	MAP2K6	0.43827586
79	ITK	0.42766354
80	CSNK1A1	0.42615979
81	CAMK1	0.41748374
82	WEE1	0.41733955
83	PDK2	0.41610981
84	FER	0.40349997
85	PLK1	0.39616458
86	MINK1	0.39405112
87	STK3	0.39313919
88	PRKCI	0.38206509
89	ATR	0.37558124
90	PRKCZ	0.37132850
91	GRK5	0.36470361
92	PRKCA	0.36458893
93	CSNK1D	0.34033607
94	ERBB2	0.33616991
95	NTRK2	0.33262560
96	CHEK2	0.32617177
97	PRKG1	0.32506782
98	DYRK1A	0.32031559
99	GRK7	0.30901504
100	NEK2	0.30747453

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	2.86924996
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.80793294
3	Phototransduction_Homo sapiens_hsa04744	2.80471273
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.63660308
5	Butanoate metabolism_Homo sapiens_hsa00650	2.45384183
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.36616522
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.33209124
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.15876754
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.07494976
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.04591170
11	Nicotine addiction_Homo sapiens_hsa05033	2.03420462
12	Parkinsons disease_Homo sapiens_hsa05012	2.02691750
13	Ether lipid metabolism_Homo sapiens_hsa00565	1.95816082
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.94352171
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.91626053
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.81221761
17	Protein export_Homo sapiens_hsa03060	1.79617855
18	Homologous recombination_Homo sapiens_hsa03440	1.79008486
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.77542216
20	Caffeine metabolism_Homo sapiens_hsa00232	1.76113013
21	RNA polymerase_Homo sapiens_hsa03020	1.74038180
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.68351270
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.64642497
24	Basal transcription factors_Homo sapiens_hsa03022	1.61839819
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.60058761
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.51126435
27	Huntingtons disease_Homo sapiens_hsa05016	1.38105703
28	One carbon pool by folate_Homo sapiens_hsa00670	1.36285238
29	Olfactory transduction_Homo sapiens_hsa04740	1.32353152
30	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.30849908
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.26118246
32	Propanoate metabolism_Homo sapiens_hsa00640	1.26018550
33	Peroxisome_Homo sapiens_hsa04146	1.25085987
34	Alzheimers disease_Homo sapiens_hsa05010	1.22653709
35	Morphine addiction_Homo sapiens_hsa05032	1.20288826
36	Taste transduction_Homo sapiens_hsa04742	1.19667643
37	Sulfur relay system_Homo sapiens_hsa04122	1.18849370
38	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.18518717
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.16572674
40	RNA degradation_Homo sapiens_hsa03018	1.13225474
41	Regulation of autophagy_Homo sapiens_hsa04140	1.09409993
42	Cardiac muscle contraction_Homo sapiens_hsa04260	1.06889009
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.05189492
44	Proteasome_Homo sapiens_hsa03050	1.04317034
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03859283
46	Retinol metabolism_Homo sapiens_hsa00830	1.00462281
47	Fat digestion and absorption_Homo sapiens_hsa04975	1.00041563
48	Collecting duct acid secretion_Homo sapiens_hsa04966	0.99163433
49	Ribosome_Homo sapiens_hsa03010	0.98901491
50	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.98383287
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.97436432
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.96817085
53	ABC transporters_Homo sapiens_hsa02010	0.94227413
54	Serotonergic synapse_Homo sapiens_hsa04726	0.92893260
55	Insulin secretion_Homo sapiens_hsa04911	0.92085903
56	Asthma_Homo sapiens_hsa05310	0.88971096
57	Purine metabolism_Homo sapiens_hsa00230	0.87311985
58	GABAergic synapse_Homo sapiens_hsa04727	0.83801077
59	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.83538541
60	Circadian entrainment_Homo sapiens_hsa04713	0.83308804
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.81990200
62	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.78247612
63	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.78237543
64	Histidine metabolism_Homo sapiens_hsa00340	0.77254090
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.74021243
66	Metabolic pathways_Homo sapiens_hsa01100	0.73476307
67	Salivary secretion_Homo sapiens_hsa04970	0.73414947
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70646592
69	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.67881188
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67848771
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66032354
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.65486303
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.61169314
74	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60890235
75	Non-homologous end-joining_Homo sapiens_hsa03450	0.60243827
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.60114578
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.59494327
78	Fatty acid elongation_Homo sapiens_hsa00062	0.58114875
79	Nucleotide excision repair_Homo sapiens_hsa03420	0.55724390
80	Sulfur metabolism_Homo sapiens_hsa00920	0.53994127
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52105769
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.48559927
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.48351322
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47423472
85	Mismatch repair_Homo sapiens_hsa03430	0.47401649
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.47102118
87	Fatty acid degradation_Homo sapiens_hsa00071	0.47057454
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.47056451
89	Base excision repair_Homo sapiens_hsa03410	0.45325324
90	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45098926
91	RNA transport_Homo sapiens_hsa03013	0.44927642
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44073105
93	Type I diabetes mellitus_Homo sapiens_hsa04940	0.43097822
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.42674962
95	Primary immunodeficiency_Homo sapiens_hsa05340	0.42320620
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.39131651
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.36398257
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36264737
99	Mineral absorption_Homo sapiens_hsa04978	0.35562036
100	Pancreatic secretion_Homo sapiens_hsa04972	0.33718798

PDCD6IPP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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