PDCD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 59 kDa protein that is associated with the U11 small nuclear ribonucleoprotein (snRNP), which is a component of the minor U12-type spliceosome responsible for catalyzing pre-mRNA splicing of U12-type introns. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.69148953
2translational termination (GO:0006415)6.47297633
3ribosomal small subunit biogenesis (GO:0042274)5.98937427
4ribosomal small subunit assembly (GO:0000028)5.97910591
5translational elongation (GO:0006414)5.30994774
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.29653298
7cotranslational protein targeting to membrane (GO:0006613)5.28299429
8protein targeting to ER (GO:0045047)5.21130793
9establishment of protein localization to endoplasmic reticulum (GO:0072599)5.01937787
10nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.92207553
11viral life cycle (GO:0019058)4.90662335
12cellular protein complex disassembly (GO:0043624)4.90258989
13protein localization to endoplasmic reticulum (GO:0070972)4.88349879
14mitotic metaphase plate congression (GO:0007080)4.86827452
15piRNA metabolic process (GO:0034587)4.79849906
16substrate-independent telencephalic tangential migration (GO:0021826)4.56135087
17substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.56135087
18behavioral response to nicotine (GO:0035095)4.45838287
19translational initiation (GO:0006413)4.42751431
20somatic diversification of immune receptors via somatic mutation (GO:0002566)4.37948331
21somatic hypermutation of immunoglobulin genes (GO:0016446)4.37948331
22protein complex disassembly (GO:0043241)4.36771597
23maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.34847387
24protein K6-linked ubiquitination (GO:0085020)4.33610583
25replication fork processing (GO:0031297)4.29801082
26attachment of spindle microtubules to kinetochore (GO:0008608)4.27853116
27protein localization to kinetochore (GO:0034501)4.21830861
28macromolecular complex disassembly (GO:0032984)4.18303277
29chaperone-mediated protein transport (GO:0072321)4.16312962
30DNA replication checkpoint (GO:0000076)4.16160683
31cell proliferation in forebrain (GO:0021846)4.01288474
32metaphase plate congression (GO:0051310)4.00066349
33base-excision repair, AP site formation (GO:0006285)3.93507659
34mitotic chromosome condensation (GO:0007076)3.84761429
35protein localization to chromosome, centromeric region (GO:0071459)3.84718859
36mitotic sister chromatid segregation (GO:0000070)3.79172791
37DNA deamination (GO:0045006)3.78922700
38negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.69796115
39negative regulation of DNA-templated transcription, elongation (GO:0032785)3.69796115
40DNA strand elongation involved in DNA replication (GO:0006271)3.67449086
41DNA replication initiation (GO:0006270)3.65948664
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.64287353
43protein targeting to membrane (GO:0006612)3.63309001
44nuclear-transcribed mRNA catabolic process (GO:0000956)3.62641106
45regulation of sister chromatid cohesion (GO:0007063)3.61804648
46positive regulation of chromosome segregation (GO:0051984)3.61584473
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.58159828
48telomere maintenance via semi-conservative replication (GO:0032201)3.57551150
49regulation of meiosis I (GO:0060631)3.56855223
50negative regulation of meiosis (GO:0045835)3.56647269
51protein localization to chromosome (GO:0034502)3.52752645
52DNA unwinding involved in DNA replication (GO:0006268)3.52648434
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.51990184
54mitotic nuclear envelope disassembly (GO:0007077)3.51475446
55histone H2A monoubiquitination (GO:0035518)3.50089788
56establishment of chromosome localization (GO:0051303)3.49242121
57meiotic chromosome segregation (GO:0045132)3.48035191
58maturation of 5.8S rRNA (GO:0000460)3.47591075
59mRNA catabolic process (GO:0006402)3.44179128
60nonmotile primary cilium assembly (GO:0035058)3.43506501
61DNA strand elongation (GO:0022616)3.43275209
62ribosomal large subunit biogenesis (GO:0042273)3.41856203
63DNA replication-independent nucleosome organization (GO:0034724)3.40288237
64DNA replication-independent nucleosome assembly (GO:0006336)3.40288237
65histone H2A ubiquitination (GO:0033522)3.35156326
66regulation of spindle organization (GO:0090224)3.34609181
67ribosome biogenesis (GO:0042254)3.33807428
68kinetochore assembly (GO:0051382)3.33334656
69gene silencing by RNA (GO:0031047)3.33310590
70chromatin remodeling at centromere (GO:0031055)3.33155630
71ATP synthesis coupled proton transport (GO:0015986)3.32985984
72energy coupled proton transport, down electrochemical gradient (GO:0015985)3.32985984
73CENP-A containing nucleosome assembly (GO:0034080)3.32668942
74nuclear envelope disassembly (GO:0051081)3.32509456
75membrane disassembly (GO:0030397)3.32509456
76formation of translation preinitiation complex (GO:0001731)3.30881898
77regulation of meiosis (GO:0040020)3.30751866
78regulation of DNA methylation (GO:0044030)3.30732899
79female gamete generation (GO:0007292)3.30480896
80negative regulation of histone methylation (GO:0031061)3.30157745
81regulation of nuclear cell cycle DNA replication (GO:0033262)3.29595924
82meiotic cell cycle (GO:0051321)3.28862877
83regulation of double-strand break repair via homologous recombination (GO:0010569)3.28838247
84regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.27655031
85ribonucleoprotein complex biogenesis (GO:0022613)3.26868233
86telomere maintenance via recombination (GO:0000722)3.24112384
87translation (GO:0006412)3.23980522
88mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.22499232
89telomere maintenance via telomerase (GO:0007004)3.21350751
90kinetochore organization (GO:0051383)3.17958280
91RNA catabolic process (GO:0006401)3.17181770
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16249408
93regulation of exit from mitosis (GO:0007096)3.16048045
94histone exchange (GO:0043486)3.15911413
95regulation of histone H3-K9 methylation (GO:0051570)3.15720789
96chromatin assembly or disassembly (GO:0006333)3.15597157
97somite development (GO:0061053)3.15011384
98ribosome assembly (GO:0042255)3.14704510
99sister chromatid segregation (GO:0000819)3.14323442
100spliceosomal complex assembly (GO:0000245)3.12756644
101telomere maintenance via telomere lengthening (GO:0010833)3.12653892
102regulation of helicase activity (GO:0051095)3.11929776
103positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.10099096
104positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.10099096
105positive regulation of mitotic sister chromatid separation (GO:1901970)3.10099096
106cellular component biogenesis (GO:0044085)3.09050282
107regulation of gene silencing by RNA (GO:0060966)3.08515213
108regulation of posttranscriptional gene silencing (GO:0060147)3.08515213
109regulation of gene silencing by miRNA (GO:0060964)3.08515213
110nucleotide-excision repair, DNA gap filling (GO:0006297)3.06917040
111regulation of chromosome segregation (GO:0051983)3.06704453
112tongue development (GO:0043586)3.04068515
113negative regulation of meiotic cell cycle (GO:0051447)3.02924590
114regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01116036
115mitotic recombination (GO:0006312)3.00948014
116protein-cofactor linkage (GO:0018065)2.99286041
117positive regulation of histone H3-K4 methylation (GO:0051571)2.99277349
118chromosome segregation (GO:0007059)2.99053487
119regulation of female gonad development (GO:2000194)2.98585827
120forebrain neuron differentiation (GO:0021879)2.98286087
121negative regulation of chromosome segregation (GO:0051985)2.97160775
122spindle checkpoint (GO:0031577)2.96795633
123epithelial cilium movement (GO:0003351)2.96728157
124transcription from mitochondrial promoter (GO:0006390)2.96636174
125regulation of RNA export from nucleus (GO:0046831)2.94853894
126DNA replication-dependent nucleosome assembly (GO:0006335)2.94087390
127DNA replication-dependent nucleosome organization (GO:0034723)2.94087390
128base-excision repair (GO:0006284)2.94015638
129establishment of protein localization to mitochondrial membrane (GO:0090151)2.91420710
130maturation of SSU-rRNA (GO:0030490)2.91365759
131DNA damage response, signal transduction resulting in transcription (GO:0042772)2.91102104
132neuron fate determination (GO:0048664)2.90661470
133regulation of DNA damage checkpoint (GO:2000001)2.87609253
134histone H4-K12 acetylation (GO:0043983)2.86704744
135pyrimidine nucleotide catabolic process (GO:0006244)2.85604195
136heterochromatin organization (GO:0070828)2.84488448
137monoubiquitinated protein deubiquitination (GO:0035520)2.84232307
138mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84211421
139mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83667864
140mitochondrial respiratory chain complex I assembly (GO:0032981)2.83667864
141NADH dehydrogenase complex assembly (GO:0010257)2.83667864
142inner cell mass cell proliferation (GO:0001833)2.81928624
143nuclear envelope organization (GO:0006998)2.81755185
144snRNA metabolic process (GO:0016073)2.81022597
145DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.79761117
146DNA methylation involved in gamete generation (GO:0043046)2.79251650
147protein complex biogenesis (GO:0070271)2.76999798
148male meiosis I (GO:0007141)2.74334784
149head development (GO:0060322)2.73812953
150positive regulation of gastrulation (GO:2000543)2.71737127
151postsynaptic membrane organization (GO:0001941)2.69885299
152protein neddylation (GO:0045116)2.68660264
153retinal ganglion cell axon guidance (GO:0031290)2.65493121
154mitochondrial respiratory chain complex assembly (GO:0033108)2.65477193
155rRNA processing (GO:0006364)2.65365027
156auditory receptor cell differentiation (GO:0042491)2.65334652
157mechanosensory behavior (GO:0007638)2.64064561
158water-soluble vitamin biosynthetic process (GO:0042364)2.58943411
159rRNA metabolic process (GO:0016072)2.58242593
160intracellular protein transmembrane import (GO:0044743)2.58031093
161synapsis (GO:0007129)2.57607535
162regulation of DNA endoreduplication (GO:0032875)2.51737538
163respiratory electron transport chain (GO:0022904)2.50744864
164electron transport chain (GO:0022900)2.49653126
165regulation of mitochondrial translation (GO:0070129)2.48798183
166protein targeting (GO:0006605)2.45267183
167cerebral cortex radially oriented cell migration (GO:0021799)2.42644777
168reciprocal DNA recombination (GO:0035825)2.42122265
169reciprocal meiotic recombination (GO:0007131)2.42122265
170centriole replication (GO:0007099)2.41902535
171establishment of protein localization to organelle (GO:0072594)2.40419998
172establishment of protein localization to membrane (GO:0090150)2.40403872
173resolution of meiotic recombination intermediates (GO:0000712)2.38738217
174termination of RNA polymerase III transcription (GO:0006386)2.38674764
175transcription elongation from RNA polymerase III promoter (GO:0006385)2.38674764
176RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.37871371
177tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.37871371
178negative regulation of telomere maintenance (GO:0032205)2.37483640
179histone H3-K4 trimethylation (GO:0080182)2.36749875
180nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.36213482
181axon ensheathment in central nervous system (GO:0032291)2.35372408
182central nervous system myelination (GO:0022010)2.35372408
183regulation of cilium movement (GO:0003352)2.35363280
184negative regulation of astrocyte differentiation (GO:0048712)2.34829252
185presynaptic membrane organization (GO:0097090)2.34765011
186intraciliary transport (GO:0042073)2.34671613
187neuronal stem cell maintenance (GO:0097150)2.30600531
188negative regulation of DNA-dependent DNA replication (GO:2000104)2.29161094

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.42761746
2EZH2_22144423_ChIP-Seq_EOC_Human6.40508763
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.55052670
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.66617297
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.39508094
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.37163518
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05427698
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.95546895
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.80375229
10* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76586576
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.74170967
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.64407552
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57191170
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54578523
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52836638
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.51106747
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.50726200
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45566433
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45044852
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40705725
21ZNF274_21170338_ChIP-Seq_K562_Hela2.33931102
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.32109269
23POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.22473162
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21806521
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10724344
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.09500147
27TP63_19390658_ChIP-ChIP_HaCaT_Human2.06409349
28* MYC_22102868_ChIP-Seq_BL_Human2.06125387
29AR_21909140_ChIP-Seq_LNCAP_Human2.06031587
30XRN2_22483619_ChIP-Seq_HELA_Human2.03687587
31* GABP_19822575_ChIP-Seq_HepG2_Human1.99776136
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96420024
33* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93759280
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.92158921
35FOXP3_21729870_ChIP-Seq_TREG_Human1.89478586
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87640776
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.86070167
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82708278
39DCP1A_22483619_ChIP-Seq_HELA_Human1.82601369
40VDR_23849224_ChIP-Seq_CD4+_Human1.80928239
41VDR_22108803_ChIP-Seq_LS180_Human1.78577168
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.76362292
43TTF2_22483619_ChIP-Seq_HELA_Human1.76251082
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76232930
45CIITA_25753668_ChIP-Seq_RAJI_Human1.74411979
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73105370
47KDM5A_27292631_Chip-Seq_BREAST_Human1.67090517
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65648894
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63393819
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.63199224
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61097117
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60653627
53EWS_26573619_Chip-Seq_HEK293_Human1.60044505
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.58302642
55ZNF263_19887448_ChIP-Seq_K562_Human1.57165070
56FUS_26573619_Chip-Seq_HEK293_Human1.53212310
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52851063
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.52391876
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50492282
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.50100935
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48686037
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48686037
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48686037
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48513300
65* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45976629
66IRF1_19129219_ChIP-ChIP_H3396_Human1.44829387
67* NANOG_21062744_ChIP-ChIP_HESCs_Human1.43715156
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41677282
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.41007169
70VDR_21846776_ChIP-Seq_THP-1_Human1.39421767
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37783675
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37668296
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37623267
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37149647
75REST_21632747_ChIP-Seq_MESCs_Mouse1.35875901
76* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34952451
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33699024
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33643325
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.30301508
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.30176744
81RNF2_27304074_Chip-Seq_NSC_Mouse1.29375610
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29193233
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29080369
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27776302
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26557126
86JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25743849
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25184238
88TP53_22573176_ChIP-Seq_HFKS_Human1.24758265
89* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24266936
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23106620
91MYC_18940864_ChIP-ChIP_HL60_Human1.22766096
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22259881
93* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21568243
94* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20256063
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20020875
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16844241
97* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16006912
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15561530
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14850594
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13879236
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13879236
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12653148
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11809784
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11733450
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11468064
106* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09578833
107HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08280120
108REST_18959480_ChIP-ChIP_MESCs_Mouse1.06763381
109ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06162433
110RNF2_27304074_Chip-Seq_ESCs_Mouse1.05979566
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05111665
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05028395
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03738472
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02550935
115* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01241035
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01230074
117CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00758049
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00516378
119GATA1_26923725_Chip-Seq_HPCs_Mouse0.99631632
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98967832
121ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98091018
122TFEB_21752829_ChIP-Seq_HELA_Human0.96627169
123* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96075173
124CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95003890
125* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94477544
126* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.91913314
127PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91469976
128ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90908882
129EZH2_27294783_Chip-Seq_ESCs_Mouse0.90876079
130SRF_21415370_ChIP-Seq_HL-1_Mouse0.90262497
131* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90176822
132ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88125809
133SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87524571
134MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86512062
135FOXP1_21924763_ChIP-Seq_HESCs_Human0.86425124
136SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.84743791
137EED_16625203_ChIP-ChIP_MESCs_Mouse0.83950745
138CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83684499
139SUZ12_27294783_Chip-Seq_ESCs_Mouse0.83604918
140TCF7_22412390_ChIP-Seq_EML_Mouse0.83584456
141NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.82896549
142ELK1_19687146_ChIP-ChIP_HELA_Human0.82805641
143ERA_21632823_ChIP-Seq_H3396_Human0.82343442
144RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82065938
145ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81988740
146* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81480506
147GBX2_23144817_ChIP-Seq_PC3_Human0.81140716
148* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81038351
149SPI1_23547873_ChIP-Seq_NB4_Human0.79400151
150SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.79238800
151TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78154582
152NANOG_16153702_ChIP-ChIP_HESCs_Human0.76672418
153P300_19829295_ChIP-Seq_ESCs_Human0.76254781
154TP53_20018659_ChIP-ChIP_R1E_Mouse0.76131559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.02822217
2MP0008057_abnormal_DNA_replication5.34706991
3MP0010094_abnormal_chromosome_stability4.70396034
4MP0003693_abnormal_embryo_hatching4.49936552
5MP0003111_abnormal_nucleus_morphology4.29387777
6MP0004957_abnormal_blastocyst_morpholog3.83508767
7MP0008877_abnormal_DNA_methylation3.59386800
8MP0003077_abnormal_cell_cycle3.55243360
9MP0003718_maternal_effect3.38548052
10MP0008058_abnormal_DNA_repair2.97949089
11MP0000537_abnormal_urethra_morphology2.97147128
12MP0006292_abnormal_olfactory_placode2.51594227
13MP0003123_paternal_imprinting2.44195185
14MP0002009_preneoplasia2.38206699
15MP0003646_muscle_fatigue2.28766261
16MP0002653_abnormal_ependyma_morphology2.19776402
17MP0003122_maternal_imprinting2.04526696
18MP0002837_dystrophic_cardiac_calcinosis2.02692239
19MP0000350_abnormal_cell_proliferation2.01854880
20MP0000778_abnormal_nervous_system2.00072022
21MP0008932_abnormal_embryonic_tissue1.99206354
22MP0008789_abnormal_olfactory_epithelium1.97876732
23MP0001929_abnormal_gametogenesis1.89137606
24MP0001730_embryonic_growth_arrest1.89075262
25MP0000631_abnormal_neuroendocrine_gland1.88984049
26MP0002396_abnormal_hematopoietic_system1.88847764
27MP0002210_abnormal_sex_determination1.88637369
28MP0003786_premature_aging1.86148068
29MP0000490_abnormal_crypts_of1.84246061
30MP0008007_abnormal_cellular_replicative1.82278786
31MP0005499_abnormal_olfactory_system1.82020346
32MP0005394_taste/olfaction_phenotype1.82020346
33MP0004885_abnormal_endolymph1.81038907
34MP0002938_white_spotting1.80798003
35MP0000049_abnormal_middle_ear1.79927179
36MP0000653_abnormal_sex_gland1.71936160
37MP0004142_abnormal_muscle_tone1.67346717
38MP0001145_abnormal_male_reproductive1.66614557
39MP0003121_genomic_imprinting1.62092860
40MP0001529_abnormal_vocalization1.62039424
41MP0003880_abnormal_central_pattern1.60459798
42MP0001697_abnormal_embryo_size1.58863854
43MP0008995_early_reproductive_senescence1.57382410
44MP0002085_abnormal_embryonic_tissue1.56220201
45MP0002095_abnormal_skin_pigmentation1.55849403
46MP0003787_abnormal_imprinting1.55346591
47MP0005380_embryogenesis_phenotype1.54304430
48MP0001672_abnormal_embryogenesis/_devel1.54304430
49MP0001485_abnormal_pinna_reflex1.51682764
50MP0002019_abnormal_tumor_incidence1.49771670
51MP0001119_abnormal_female_reproductive1.49677731
52MP0002160_abnormal_reproductive_system1.49480837
53MP0002084_abnormal_developmental_patter1.48227484
54MP0004808_abnormal_hematopoietic_stem1.46514818
55MP0003763_abnormal_thymus_physiology1.44872574
56MP0009278_abnormal_bone_marrow1.43512171
57MP0010307_abnormal_tumor_latency1.38114090
58MP0003567_abnormal_fetal_cardiomyocyte1.38055704
59MP0003699_abnormal_female_reproductive1.36425147
60MP0005645_abnormal_hypothalamus_physiol1.35961357
61MP0003315_abnormal_perineum_morphology1.35901357
62MP0008260_abnormal_autophagy1.35383977
63MP0002272_abnormal_nervous_system1.35221093
64MP0002163_abnormal_gland_morphology1.31861623
65MP0005423_abnormal_somatic_nervous1.31826706
66MP0001545_abnormal_hematopoietic_system1.31398655
67MP0005397_hematopoietic_system_phenotyp1.31398655
68MP0006276_abnormal_autonomic_nervous1.29924519
69MP0002080_prenatal_lethality1.27957851
70MP0001968_abnormal_touch/_nociception1.25989036
71MP0010352_gastrointestinal_tract_polyps1.25465167
72MP0004133_heterotaxia1.23962683
73MP0004742_abnormal_vestibular_system1.22834300
74MP0001188_hyperpigmentation1.21823993
75MP0003984_embryonic_growth_retardation1.21611723
76MP0000372_irregular_coat_pigmentation1.21053358
77MP0002088_abnormal_embryonic_growth/wei1.19582510
78MP0000313_abnormal_cell_death1.17885578
79MP0002086_abnormal_extraembryonic_tissu1.17259655
80MP0002184_abnormal_innervation1.16969734
81MP0010030_abnormal_orbit_morphology1.15674216
82MP0005551_abnormal_eye_electrophysiolog1.15510805
83MP0001502_abnormal_circadian_rhythm1.15172281
84MP0006072_abnormal_retinal_apoptosis1.14700672
85MP0001286_abnormal_eye_development1.14554895
86MP0000703_abnormal_thymus_morphology1.13582630
87MP0009333_abnormal_splenocyte_physiolog1.13481916
88MP0005395_other_phenotype1.13005263
89MP0000955_abnormal_spinal_cord1.12250169
90MP0002234_abnormal_pharynx_morphology1.10555200
91MP0002752_abnormal_somatic_nervous1.09275646
92MP0000026_abnormal_inner_ear1.08612133
93MP0005389_reproductive_system_phenotype1.07785284
94MP0002398_abnormal_bone_marrow1.07519269
95MP0002736_abnormal_nociception_after1.06188341
96MP0002233_abnormal_nose_morphology1.05306959
97MP0009745_abnormal_behavioral_response1.05208210
98MP0002161_abnormal_fertility/fecundity1.04728507
99MP0002557_abnormal_social/conspecific_i1.02915113
100MP0002152_abnormal_brain_morphology1.02618214
101MP0002572_abnormal_emotion/affect_behav1.01802647
102MP0010386_abnormal_urinary_bladder1.00624972
103MP0003635_abnormal_synaptic_transmissio1.00323858
104MP0002102_abnormal_ear_morphology0.98827872
105MP0001986_abnormal_taste_sensitivity0.98356623
106MP0000689_abnormal_spleen_morphology0.98106995
107MP0000569_abnormal_digit_pigmentation0.95806432
108MP0001984_abnormal_olfaction0.95710490
109MP0005195_abnormal_posterior_eye0.95184875
110MP0003698_abnormal_male_reproductive0.94345482
111MP0009250_abnormal_appendicular_skeleto0.93738960
112MP0003942_abnormal_urinary_system0.93135649
113MP0000427_abnormal_hair_cycle0.92796596
114MP0000015_abnormal_ear_pigmentation0.91578535
115MP0005377_hearing/vestibular/ear_phenot0.91414882
116MP0003878_abnormal_ear_physiology0.91414882
117MP0005646_abnormal_pituitary_gland0.90917808
118MP0002063_abnormal_learning/memory/cond0.89060987
119MP0003890_abnormal_embryonic-extraembry0.87319973
120MP0005174_abnormal_tail_pigmentation0.87210083
121MP0002722_abnormal_immune_system0.86333291
122MP0002882_abnormal_neuron_morphology0.85768047
123MP0009046_muscle_twitch0.85638897
124MP0004197_abnormal_fetal_growth/weight/0.84557912
125MP0000566_synostosis0.84355958
126MP0002734_abnormal_mechanical_nocicepti0.82448720
127MP0005310_abnormal_salivary_gland0.80338085
128MP0005621_abnormal_cell_physiology0.80297656
129MP0001963_abnormal_hearing_physiology0.79091019
130MP0001486_abnormal_startle_reflex0.76775422
131MP0002067_abnormal_sensory_capabilities0.75087443
132MP0003119_abnormal_digestive_system0.74984338
133MP0002116_abnormal_craniofacial_bone0.73776410
134MP0003283_abnormal_digestive_organ0.73628502
135MP0005379_endocrine/exocrine_gland_phen0.73362443
136MP0005384_cellular_phenotype0.72928581
137MP0002751_abnormal_autonomic_nervous0.72519507
138MP0005451_abnormal_body_composition0.72415769
139MP0004811_abnormal_neuron_physiology0.71356478
140MP0002697_abnormal_eye_size0.71214849
141MP0003937_abnormal_limbs/digits/tail_de0.70794583
142MP0005076_abnormal_cell_differentiation0.70645961
143MP0000465_gastrointestinal_hemorrhage0.65934631
144MP0001905_abnormal_dopamine_level0.65522766
145MP0003861_abnormal_nervous_system0.65480525
146MP0002429_abnormal_blood_cell0.64515091
147MP0002269_muscular_atrophy0.64265055
148MP0004185_abnormal_adipocyte_glucose0.63038549
149MP0003938_abnormal_ear_development0.62370934
150MP0000716_abnormal_immune_system0.61447374
151MP0000358_abnormal_cell_content/0.60260496
152MP0001727_abnormal_embryo_implantation0.57934563
153MP0003755_abnormal_palate_morphology0.56026046
154MP0004264_abnormal_extraembryonic_tissu0.55637901
155MP0000477_abnormal_intestine_morphology0.55506848
156MP0001293_anophthalmia0.54350994
157MP0009672_abnormal_birth_weight0.53892415
158MP0002132_abnormal_respiratory_system0.53691253
159MP0003136_yellow_coat_color0.51477831
160MP0002114_abnormal_axial_skeleton0.51413860
161MP0008770_decreased_survivor_rate0.50839397
162MP0002249_abnormal_larynx_morphology0.49571401
163MP0001915_intracranial_hemorrhage0.48537259
164MP0009703_decreased_birth_body0.44997668
165MP0002405_respiratory_system_inflammati0.44921025
166MP0005075_abnormal_melanosome_morpholog0.44766179
167MP0002111_abnormal_tail_morphology0.43690990

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.13490861
2Facial hemangioma (HP:0000329)4.60742899
3Patellar aplasia (HP:0006443)4.14758079
4Male infertility (HP:0003251)4.14260094
5Breast hypoplasia (HP:0003187)4.12499408
6Selective tooth agenesis (HP:0001592)4.00977284
7Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.85858488
8Molar tooth sign on MRI (HP:0002419)3.83586607
9Abnormality of midbrain morphology (HP:0002418)3.83586607
10Abnormality of the labia minora (HP:0012880)3.83083925
11Aplasia/Hypoplasia of the patella (HP:0006498)3.80157402
12Premature ovarian failure (HP:0008209)3.62392374
13Type II lissencephaly (HP:0007260)3.56513215
14Overlapping toe (HP:0001845)3.47243287
15Carpal bone hypoplasia (HP:0001498)3.38661722
16Abnormality of lateral ventricle (HP:0030047)3.31132752
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.30692080
18Pancreatic fibrosis (HP:0100732)3.24644062
19Supernumerary spleens (HP:0009799)3.23268678
20Chromsome breakage (HP:0040012)3.22224908
21Macrocytic anemia (HP:0001972)3.20050536
22Colon cancer (HP:0003003)3.12593464
23Myelodysplasia (HP:0002863)3.10542171
24Neoplasm of the oral cavity (HP:0100649)3.06527743
25Capillary hemangiomas (HP:0005306)3.06085489
26Broad alveolar ridges (HP:0000187)3.01446324
27Absent thumb (HP:0009777)2.96600916
28Medial flaring of the eyebrow (HP:0010747)2.92601008
29Lipid accumulation in hepatocytes (HP:0006561)2.92306959
30Septo-optic dysplasia (HP:0100842)2.92093080
31Rhabdomyosarcoma (HP:0002859)2.91303489
32Increased hepatocellular lipid droplets (HP:0006565)2.89600788
33Shawl scrotum (HP:0000049)2.88968167
34Abnormality of the preputium (HP:0100587)2.84856129
35Abnormality of the ileum (HP:0001549)2.84592607
36True hermaphroditism (HP:0010459)2.83982513
37Acute necrotizing encephalopathy (HP:0006965)2.83477236
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.82434638
39Meckel diverticulum (HP:0002245)2.78119571
40Abnormality of chromosome stability (HP:0003220)2.76130384
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.75874023
42Retinal dysplasia (HP:0007973)2.73414786
43Prominent nose (HP:0000448)2.71793506
44Absent radius (HP:0003974)2.69752272
45Volvulus (HP:0002580)2.68778857
46Absent forearm bone (HP:0003953)2.65962191
47Aplasia involving forearm bones (HP:0009822)2.65962191
48Chronic hepatic failure (HP:0100626)2.64899284
49Broad palm (HP:0001169)2.57848756
50Cerebellar dysplasia (HP:0007033)2.57363205
51Pallor (HP:0000980)2.55689279
52Mitochondrial inheritance (HP:0001427)2.50364195
53Nephronophthisis (HP:0000090)2.49146011
54Lissencephaly (HP:0001339)2.45606526
55Thrombocytosis (HP:0001894)2.45564084
56Acute encephalopathy (HP:0006846)2.41577035
57Aplastic anemia (HP:0001915)2.41143469
58Ependymoma (HP:0002888)2.39324432
59Impulsivity (HP:0100710)2.38407914
60Microretrognathia (HP:0000308)2.37416074
61Squamous cell carcinoma (HP:0002860)2.36588259
62Abnormal mitochondria in muscle tissue (HP:0008316)2.36295535
63Amaurosis fugax (HP:0100576)2.35056964
64Rib fusion (HP:0000902)2.34852098
65Small intestinal stenosis (HP:0012848)2.34394964
66Duodenal stenosis (HP:0100867)2.34394964
67Aplasia/Hypoplasia of the spleen (HP:0010451)2.33787781
68Sclerocornea (HP:0000647)2.31964749
69Progressive macrocephaly (HP:0004481)2.29496489
70Secondary amenorrhea (HP:0000869)2.29243313
71Pendular nystagmus (HP:0012043)2.27505505
72Anencephaly (HP:0002323)2.27220467
73Cerebral hypomyelination (HP:0006808)2.26142337
74CNS hypomyelination (HP:0003429)2.22366020
75Infertility (HP:0000789)2.20714331
76Sloping forehead (HP:0000340)2.19563102
77Gait imbalance (HP:0002141)2.18873150
78Abnormality of cells of the erythroid lineage (HP:0012130)2.18791343
79Increased CSF lactate (HP:0002490)2.17620566
80Polycythemia (HP:0001901)2.15469621
81Median cleft lip (HP:0000161)2.15001845
82Abnormal spermatogenesis (HP:0008669)2.14945919
83Hyperventilation (HP:0002883)2.14506972
84Dynein arm defect of respiratory motile cilia (HP:0012255)2.14417142
85Absent/shortened dynein arms (HP:0200106)2.14417142
86Bone marrow hypocellularity (HP:0005528)2.14131802
8711 pairs of ribs (HP:0000878)2.14040402
88Abnormality of the renal medulla (HP:0100957)2.12317702
89Tongue fasciculations (HP:0001308)2.12085487
90Cafe-au-lait spot (HP:0000957)2.11800185
91Neoplasm of striated muscle (HP:0009728)2.11408716
92Muscle fiber atrophy (HP:0100295)2.10781873
93Posterior subcapsular cataract (HP:0007787)2.09631348
94Abnormal respiratory motile cilium morphology (HP:0005938)2.08938645
95Abnormal respiratory epithelium morphology (HP:0012253)2.08938645
96Optic nerve hypoplasia (HP:0000609)2.08880554
97Pachygyria (HP:0001302)2.08260245
98Asplenia (HP:0001746)2.07842719
99Depressed nasal ridge (HP:0000457)2.06772674
100Medulloblastoma (HP:0002885)2.04655934
101Anophthalmia (HP:0000528)2.03365110
102Congenital primary aphakia (HP:0007707)2.03224333
103Exertional dyspnea (HP:0002875)2.03082603
104Abnormality of DNA repair (HP:0003254)2.02540040
105Nephrogenic diabetes insipidus (HP:0009806)2.01941326
106Cortical dysplasia (HP:0002539)2.00874234
107Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00702323
108Nephroblastoma (Wilms tumor) (HP:0002667)2.00644958
109Abnormality of chromosome segregation (HP:0002916)1.99712324
110Basal cell carcinoma (HP:0002671)1.99693489
111Abnormal number of erythroid precursors (HP:0012131)1.99527972
112Azoospermia (HP:0000027)1.99420443
113Ureteral duplication (HP:0000073)1.98725431
114Aplasia/hypoplasia of the humerus (HP:0006507)1.97626396
115Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97437554
116Acute lymphatic leukemia (HP:0006721)1.96393515
117Breast aplasia (HP:0100783)1.96143162
118Pustule (HP:0200039)1.93103547
119Ectopic kidney (HP:0000086)1.93062652
120Triphalangeal thumb (HP:0001199)1.92930432
121Renal Fanconi syndrome (HP:0001994)1.91669957
122Clubbing of toes (HP:0100760)1.90480663
123Holoprosencephaly (HP:0001360)1.90066488
124Limb hypertonia (HP:0002509)1.88368167
125Abnormality of the fingertips (HP:0001211)1.88332253
126Cystic liver disease (HP:0006706)1.88000730
127Postaxial foot polydactyly (HP:0001830)1.87895064
128Hyperglycinemia (HP:0002154)1.87328017
129Muscle fibrillation (HP:0010546)1.86102361
130Agnosia (HP:0010524)1.85771345
131Embryonal renal neoplasm (HP:0011794)1.85423101
132Type 2 muscle fiber atrophy (HP:0003554)1.84944473
133Oligodactyly (HP:0012165)1.84563918
134Poikiloderma (HP:0001029)1.84514503
135Oligodactyly (hands) (HP:0001180)1.84021761
136Short humerus (HP:0005792)1.82462026
137Oral leukoplakia (HP:0002745)1.82113409
138Sandal gap (HP:0001852)1.80694845
139Postaxial hand polydactyly (HP:0001162)1.80514246
140Maternal diabetes (HP:0009800)1.79678263
141Abnormal rod and cone electroretinograms (HP:0008323)1.79224064
142Abnormality of alanine metabolism (HP:0010916)1.79211048
143Hyperalaninemia (HP:0003348)1.79211048
144Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79211048
145Reticulocytopenia (HP:0001896)1.79186822
146Highly arched eyebrow (HP:0002553)1.78855482
147Short thumb (HP:0009778)1.78284671
148Pancreatic cysts (HP:0001737)1.77673226
149Absent septum pellucidum (HP:0001331)1.77657715
150Narrow forehead (HP:0000341)1.75825791
151Aplasia/Hypoplasia of the sternum (HP:0006714)1.75656734
152Abnormality of the carotid arteries (HP:0005344)1.75508297
153Hypoplasia of the pons (HP:0012110)1.75040919
154Fetal akinesia sequence (HP:0001989)1.74407511
155Hypoplasia of the radius (HP:0002984)1.74190894
156Horseshoe kidney (HP:0000085)1.74146257
157Hypoplastic iliac wings (HP:0002866)1.73920556
158Aplasia/Hypoplasia of the tongue (HP:0010295)1.73871592
159Missing ribs (HP:0000921)1.73445066
160Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.73011584
161Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72897554
162Aplasia/Hypoplasia of the breasts (HP:0010311)1.72173001
163Abnormality of the duodenum (HP:0002246)1.71929892
1643-Methylglutaconic aciduria (HP:0003535)1.71427771
165Hepatocellular necrosis (HP:0001404)1.70442994
166Optic disc pallor (HP:0000543)1.69722518
167Myokymia (HP:0002411)1.68679595
168Abnormal number of incisors (HP:0011064)1.68677150
169Genital tract atresia (HP:0001827)1.67856388
170Abnormality of the aortic arch (HP:0012303)1.67306337
171Aganglionic megacolon (HP:0002251)1.66236133
172Anomalous pulmonary venous return (HP:0010772)1.66128227
173Dandy-Walker malformation (HP:0001305)1.65293452
174Abnormal ciliary motility (HP:0012262)1.65259770
175Vaginal atresia (HP:0000148)1.64985145
176Abnormality of the pons (HP:0007361)1.62210608
177Congenital hepatic fibrosis (HP:0002612)1.61204509
178Bilateral microphthalmos (HP:0007633)1.60555642

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K63.68621009
2CDC73.67720492
3TAF13.08522131
4BUB12.96501445
5TTK2.96194617
6CASK2.93507339
7BMPR22.91052922
8NEK22.82853695
9WEE12.77062826
10LATS22.76882922
11MOS2.66641166
12PNCK2.64604473
13STK32.40883243
14WNK42.38828614
15ZAK2.37041993
16CDK192.35031738
17VRK22.23126317
18PLK12.18754769
19CDK122.15617434
20MARK12.01618429
21CDK81.94857184
22CHEK21.94198169
23NUAK11.92740764
24TAOK31.88688470
25EPHB21.82661840
26CDK71.77779650
27EEF2K1.75644751
28TNIK1.75307840
29TLK11.66031040
30DYRK31.57888478
31MAP3K41.56306729
32RAF11.53120066
33PRKD31.50815103
34LATS11.49344690
35MAP3K91.47177580
36WNK31.46549513
37PLK41.45374331
38TAOK11.43980773
39CDK41.40854486
40ADRBK21.40826731
41STK101.40023678
42CAMK1G1.38322249
43TYRO31.30251819
44NTRK21.28847048
45PRKD21.28040330
46FRK1.20703167
47PLK31.19397988
48MATK1.18718171
49CAMK11.14200908
50KSR21.13271615
51BMPR1B1.13072285
52BRAF1.12531352
53ATR1.09678114
54MAP2K71.08779712
55AURKA1.07107622
56MELK1.06646424
57STK391.06155215
58AURKB1.04854169
59CHEK11.03837194
60STK241.03536358
61MAP3K81.02876938
62CAMK1D1.02842192
63ALK1.02493004
64SRPK10.98802921
65CDK90.98263227
66MAP3K100.97791083
67PIM10.93865393
68GRK10.91938623
69ICK0.91578691
70PRKCG0.90710160
71NEK10.90336714
72MKNK20.89418746
73PKN10.89331262
74ACVR1B0.89049635
75CDK20.87815115
76GRK60.86547207
77ATM0.85885563
78TSSK60.84026587
79STK110.83166616
80INSRR0.82344565
81PRKCH0.79974156
82STK38L0.78857513
83CSNK1G10.78489480
84MINK10.78253464
85BRSK20.75465913
86YES10.75181676
87WNK10.75008713
88SIK20.73683701
89ARAF0.72923574
90NME10.72089917
91SGK4940.71845307
92SGK2230.71845307
93RPS6KB20.71825733
94TAOK20.71582661
95MARK20.71263639
96DMPK0.69325518
97MAP3K30.69131659
98FGR0.67579861
99CDK60.64270289
100PAK30.64218620
101PRKCI0.64057021
102CAMKK10.61761423
103BCKDK0.60438812
104MAP4K20.60082170
105DYRK20.60019909
106DYRK1B0.59757220
107CDK10.59540904
108MAP4K10.59495184
109CSNK1G30.59343007
110SGK20.59214395
111KSR10.58448390
112PINK10.57721192
113STK380.57657196
114MARK30.56488904
115EPHA40.55881361
116STK160.55758344
117OXSR10.52725651
118MAP3K50.52242777
119LRRK20.52001599
120RPS6KA60.51542332
121MAP2K30.51536817
122BRSK10.51306805
123PASK0.50931659
124SGK10.49353308
125NLK0.49264168
126ADRBK10.49001377
127RPS6KA50.47652490
128MAP2K40.46974598
129PRKACA0.46917628
130CSNK1A10.46286853
131CSNK2A20.45037669
132PRKDC0.44113860
133CSNK1G20.44050361
134CSNK1E0.43293354
135CSNK1D0.42917653
136ERBB40.42833737
137MAPK150.42605101
138MKNK10.41773807
139PLK20.41498242
140VRK10.41391570
141NTRK30.41235824
142MAP3K110.41134025
143CAMK40.40264233
144MAPK130.39040573
145DAPK10.39002868
146MTOR0.38920308
147MAPK110.37333413
148PIM20.37205715
149CSNK2A10.36264808
150PAK60.35327679
151MAPK140.35083630
152NME20.34627169
153MAPK100.33914795
154AKT20.32325353
155PAK10.32220098
156PRKAA10.31220681

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.35280566
2Mismatch repair_Homo sapiens_hsa034304.24906529
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.85864965
4RNA polymerase_Homo sapiens_hsa030203.42403852
5Base excision repair_Homo sapiens_hsa034103.30169046
6Oxidative phosphorylation_Homo sapiens_hsa001903.29242286
7RNA transport_Homo sapiens_hsa030133.22813598
8Cell cycle_Homo sapiens_hsa041103.07718339
9Parkinsons disease_Homo sapiens_hsa050122.85841128
10Homologous recombination_Homo sapiens_hsa034402.80964633
11Nucleotide excision repair_Homo sapiens_hsa034202.74398207
12Spliceosome_Homo sapiens_hsa030402.72459636
13Fanconi anemia pathway_Homo sapiens_hsa034602.64336062
14Non-homologous end-joining_Homo sapiens_hsa034502.62838045
15Basal transcription factors_Homo sapiens_hsa030222.62584488
16mRNA surveillance pathway_Homo sapiens_hsa030152.46215592
17RNA degradation_Homo sapiens_hsa030182.34207920
18Huntingtons disease_Homo sapiens_hsa050162.18973289
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.14401990
20Protein export_Homo sapiens_hsa030602.13087666
21Cardiac muscle contraction_Homo sapiens_hsa042602.11322245
22Ribosome_Homo sapiens_hsa030102.00571092
23Oocyte meiosis_Homo sapiens_hsa041141.99155652
24Pyrimidine metabolism_Homo sapiens_hsa002401.85531854
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79794039
26Alzheimers disease_Homo sapiens_hsa050101.74381470
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71608253
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67004932
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.66354325
30Phototransduction_Homo sapiens_hsa047441.63644479
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62923577
32Basal cell carcinoma_Homo sapiens_hsa052171.52018915
33p53 signaling pathway_Homo sapiens_hsa041151.47314169
34Proteasome_Homo sapiens_hsa030501.46266318
35Vitamin B6 metabolism_Homo sapiens_hsa007501.42595700
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37758676
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19486976
38Epstein-Barr virus infection_Homo sapiens_hsa051691.13808536
39Colorectal cancer_Homo sapiens_hsa052101.09937769
40Steroid biosynthesis_Homo sapiens_hsa001001.09817617
41Butanoate metabolism_Homo sapiens_hsa006501.05400064
42Purine metabolism_Homo sapiens_hsa002301.04052896
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03721906
44Morphine addiction_Homo sapiens_hsa050321.01733102
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99526091
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95740929
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94611552
48Propanoate metabolism_Homo sapiens_hsa006400.92565892
49Selenocompound metabolism_Homo sapiens_hsa004500.91519096
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90287777
51mTOR signaling pathway_Homo sapiens_hsa041500.88500208
52Axon guidance_Homo sapiens_hsa043600.87797041
53Tryptophan metabolism_Homo sapiens_hsa003800.85012713
54Peroxisome_Homo sapiens_hsa041460.84419483
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82001251
56Herpes simplex infection_Homo sapiens_hsa051680.80567265
57Regulation of autophagy_Homo sapiens_hsa041400.79324489
58One carbon pool by folate_Homo sapiens_hsa006700.77809045
59Collecting duct acid secretion_Homo sapiens_hsa049660.76380035
60Ovarian steroidogenesis_Homo sapiens_hsa049130.76103377
61TGF-beta signaling pathway_Homo sapiens_hsa043500.76031014
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75658094
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.75453713
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75095007
65MicroRNAs in cancer_Homo sapiens_hsa052060.74251738
66Hippo signaling pathway_Homo sapiens_hsa043900.73621015
67Circadian rhythm_Homo sapiens_hsa047100.73139865
68Notch signaling pathway_Homo sapiens_hsa043300.72681631
69Pancreatic cancer_Homo sapiens_hsa052120.71882329
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71650648
71Chronic myeloid leukemia_Homo sapiens_hsa052200.71334706
72GnRH signaling pathway_Homo sapiens_hsa049120.69542806
73GABAergic synapse_Homo sapiens_hsa047270.66168604
74Olfactory transduction_Homo sapiens_hsa047400.66094843
75HTLV-I infection_Homo sapiens_hsa051660.65650426
76Dopaminergic synapse_Homo sapiens_hsa047280.65300028
77Thyroid cancer_Homo sapiens_hsa052160.64437216
78Glutamatergic synapse_Homo sapiens_hsa047240.64130441
79Insulin secretion_Homo sapiens_hsa049110.59787046
80Dorso-ventral axis formation_Homo sapiens_hsa043200.58741005
81Primary immunodeficiency_Homo sapiens_hsa053400.58527886
82Viral carcinogenesis_Homo sapiens_hsa052030.58248636
83Alcoholism_Homo sapiens_hsa050340.58001166
84Metabolic pathways_Homo sapiens_hsa011000.56958280
85Cocaine addiction_Homo sapiens_hsa050300.56649441
86Choline metabolism in cancer_Homo sapiens_hsa052310.56458173
87Sulfur relay system_Homo sapiens_hsa041220.56136992
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55870282
89Serotonergic synapse_Homo sapiens_hsa047260.54892158
90B cell receptor signaling pathway_Homo sapiens_hsa046620.53387768
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52413591
92VEGF signaling pathway_Homo sapiens_hsa043700.51827816
93Prolactin signaling pathway_Homo sapiens_hsa049170.51486885
94Wnt signaling pathway_Homo sapiens_hsa043100.51380833
95Ether lipid metabolism_Homo sapiens_hsa005650.49704508
96Antigen processing and presentation_Homo sapiens_hsa046120.48782437
97Acute myeloid leukemia_Homo sapiens_hsa052210.48372452
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47400252
99Circadian entrainment_Homo sapiens_hsa047130.47052006
100Pyruvate metabolism_Homo sapiens_hsa006200.46903193
101Non-small cell lung cancer_Homo sapiens_hsa052230.46675122
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45296670
103Long-term depression_Homo sapiens_hsa047300.44087395
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43868387
105MAPK signaling pathway_Homo sapiens_hsa040100.43761235
106Shigellosis_Homo sapiens_hsa051310.43468496
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.43020337
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42172798
109Small cell lung cancer_Homo sapiens_hsa052220.40818477
110Estrogen signaling pathway_Homo sapiens_hsa049150.40753031
111Hepatitis B_Homo sapiens_hsa051610.39586742
112Nitrogen metabolism_Homo sapiens_hsa009100.39449224
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38784075
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38516730
115FoxO signaling pathway_Homo sapiens_hsa040680.37638660
116Cholinergic synapse_Homo sapiens_hsa047250.36952943
117Endometrial cancer_Homo sapiens_hsa052130.36743867
118Gap junction_Homo sapiens_hsa045400.36514354
119Linoleic acid metabolism_Homo sapiens_hsa005910.35808943
120Pentose phosphate pathway_Homo sapiens_hsa000300.35024369
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34404227
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.34068258
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33960451
124Melanogenesis_Homo sapiens_hsa049160.32003583
125Folate biosynthesis_Homo sapiens_hsa007900.31969174
126Melanoma_Homo sapiens_hsa052180.30916677
127Amphetamine addiction_Homo sapiens_hsa050310.30352125
128T cell receptor signaling pathway_Homo sapiens_hsa046600.30205110
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30139214
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29554177
131Apoptosis_Homo sapiens_hsa042100.28602258
132beta-Alanine metabolism_Homo sapiens_hsa004100.27727666
133Renal cell carcinoma_Homo sapiens_hsa052110.27262416
134Long-term potentiation_Homo sapiens_hsa047200.27132176
135Pathways in cancer_Homo sapiens_hsa052000.26699423
136Taste transduction_Homo sapiens_hsa047420.25791767
137Hedgehog signaling pathway_Homo sapiens_hsa043400.23880022
138Oxytocin signaling pathway_Homo sapiens_hsa049210.23839003
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.22314879
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21543581
141cAMP signaling pathway_Homo sapiens_hsa040240.21343205
142Lysine degradation_Homo sapiens_hsa003100.21160216
143Synaptic vesicle cycle_Homo sapiens_hsa047210.20752478
144Glioma_Homo sapiens_hsa052140.20619767
145ErbB signaling pathway_Homo sapiens_hsa040120.19967722
146Influenza A_Homo sapiens_hsa051640.19889222
147Bladder cancer_Homo sapiens_hsa052190.19346400
148Measles_Homo sapiens_hsa051620.18369317
149Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17599662
150Fructose and mannose metabolism_Homo sapiens_hsa000510.17469547
151Nicotine addiction_Homo sapiens_hsa050330.17197290
152Prostate cancer_Homo sapiens_hsa052150.16819122
153Systemic lupus erythematosus_Homo sapiens_hsa053220.16609127
154Biosynthesis of amino acids_Homo sapiens_hsa012300.16375258
155HIF-1 signaling pathway_Homo sapiens_hsa040660.16208430
156alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16072074
157Insulin signaling pathway_Homo sapiens_hsa049100.15710072

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