PDCL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.71208255
2CENP-A containing nucleosome assembly (GO:0034080)4.35849062
3chromatin remodeling at centromere (GO:0031055)4.34645364
4neutrophil activation involved in immune response (GO:0002283)4.09386823
5activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.04969384
6negative regulation of DNA-dependent DNA replication (GO:2000104)3.93801452
7regulation of DNA endoreduplication (GO:0032875)3.91145633
8histone exchange (GO:0043486)3.81070605
9protein localization to kinetochore (GO:0034501)3.70697105
10viral protein processing (GO:0019082)3.70493467
11proteasome assembly (GO:0043248)3.67607322
12COPI coating of Golgi vesicle (GO:0048205)3.63207593
13Golgi transport vesicle coating (GO:0048200)3.63207593
14replication fork processing (GO:0031297)3.62442361
15signal peptide processing (GO:0006465)3.59444986
16DNA damage response, detection of DNA damage (GO:0042769)3.55668195
17positive regulation of cell cycle checkpoint (GO:1901978)3.50235922
18DNA replication-independent nucleosome assembly (GO:0006336)3.48109020
19DNA replication-independent nucleosome organization (GO:0034724)3.48109020
20somatic diversification of immune receptors via somatic mutation (GO:0002566)3.35824984
21somatic hypermutation of immunoglobulin genes (GO:0016446)3.35824984
22negative regulation of DNA recombination (GO:0045910)3.30033911
23attachment of spindle microtubules to kinetochore (GO:0008608)3.28464529
24protein deneddylation (GO:0000338)3.26936608
25establishment of integrated proviral latency (GO:0075713)3.25465175
26regulation of centriole replication (GO:0046599)3.24821900
27ER overload response (GO:0006983)3.24720971
28DNA catabolic process, exonucleolytic (GO:0000738)3.24260254
29nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.21662857
30synapsis (GO:0007129)3.21023020
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19466139
32somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.18281191
33isotype switching (GO:0045190)3.18281191
34somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.18281191
35purine nucleobase biosynthetic process (GO:0009113)3.16135673
36postreplication repair (GO:0006301)3.14189235
37non-recombinational repair (GO:0000726)3.12218982
38double-strand break repair via nonhomologous end joining (GO:0006303)3.12218982
39resolution of meiotic recombination intermediates (GO:0000712)3.10023238
40RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.08543624
41negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.07917891
42sister chromatid segregation (GO:0000819)3.07294979
43regulation of double-strand break repair via homologous recombination (GO:0010569)3.05214756
44mitotic metaphase plate congression (GO:0007080)3.04602485
45protein localization to chromosome, centromeric region (GO:0071459)3.04295678
46ribosome assembly (GO:0042255)3.04159170
47DNA unwinding involved in DNA replication (GO:0006268)3.02884315
48maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01593394
49GMP metabolic process (GO:0046037)3.00935408
50protein neddylation (GO:0045116)2.99123324
51sphingomyelin metabolic process (GO:0006684)2.98877495
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.98821964
53regulation of retinoic acid receptor signaling pathway (GO:0048385)2.98458228
54regulation of meiosis I (GO:0060631)2.98153650
55maturation of SSU-rRNA (GO:0030490)2.97312941
56DNA replication checkpoint (GO:0000076)2.96954346
57monoubiquitinated protein deubiquitination (GO:0035520)2.96639321
58regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.95890993
59microtubule depolymerization (GO:0007019)2.92478848
60regulation of mitotic sister chromatid separation (GO:0010965)2.88775384
61regulation of mitotic sister chromatid segregation (GO:0033047)2.88775384
62regulation of sister chromatid segregation (GO:0033045)2.88775384
63regulation of helicase activity (GO:0051095)2.88532566
64DNA ligation (GO:0006266)2.88122886
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84455315
66protein K6-linked ubiquitination (GO:0085020)2.83585074
67histone mRNA metabolic process (GO:0008334)2.83150845
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82725008
69nucleotide transmembrane transport (GO:1901679)2.81830882
70histone H2A acetylation (GO:0043968)2.80891749
71multi-organism intracellular transport (GO:1902583)2.80545799
72transport of virus (GO:0046794)2.80545799
73intracellular transport of virus (GO:0075733)2.80545799
74multi-organism transport (GO:0044766)2.80545799
75multi-organism localization (GO:1902579)2.80545799
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79759165
77response to X-ray (GO:0010165)2.79359738
78protein prenylation (GO:0018342)2.78794170
79prenylation (GO:0097354)2.78794170
80platelet dense granule organization (GO:0060155)2.78621976
81nucleobase biosynthetic process (GO:0046112)2.77273164
82limb bud formation (GO:0060174)2.76060596
83detection of light stimulus involved in sensory perception (GO:0050962)2.74669816
84detection of light stimulus involved in visual perception (GO:0050908)2.74669816
85mitotic sister chromatid segregation (GO:0000070)2.74225170
86regulation of chromosome segregation (GO:0051983)2.73991260
87mitotic sister chromatid cohesion (GO:0007064)2.73771325
88intraciliary transport (GO:0042073)2.72894328
89regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.72806261
90establishment of viral latency (GO:0019043)2.71670387
91recombinational repair (GO:0000725)2.69924659
92sphingosine metabolic process (GO:0006670)2.69849265
93spindle checkpoint (GO:0031577)2.68637400
94DNA strand elongation involved in DNA replication (GO:0006271)2.67636368
95virion assembly (GO:0019068)2.67582968
96double-strand break repair via homologous recombination (GO:0000724)2.67543713
97metaphase plate congression (GO:0051310)2.66725670
98DNA-dependent DNA replication (GO:0006261)2.65750780
997-methylguanosine mRNA capping (GO:0006370)2.65591027
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.65191625
101RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.65191625
102kinetochore assembly (GO:0051382)2.64574362
103anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.64562698
104somatic recombination of immunoglobulin gene segments (GO:0016447)2.64058036
105maturation of 5.8S rRNA (GO:0000460)2.63643741
106negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.61454271
107negative regulation of ligase activity (GO:0051352)2.61454271
108mitotic spindle checkpoint (GO:0071174)2.61041076
109rRNA modification (GO:0000154)2.60591943
110rRNA methylation (GO:0031167)2.60512800
111mitotic spindle assembly checkpoint (GO:0007094)2.58667298
112lactate metabolic process (GO:0006089)2.58408859
113DNA strand elongation (GO:0022616)2.58068649
114somatic diversification of immunoglobulins (GO:0016445)2.57933365
115transcription elongation from RNA polymerase I promoter (GO:0006362)2.57273021
116peptidyl-histidine modification (GO:0018202)2.56832958
117spindle assembly checkpoint (GO:0071173)2.56028197
118DNA replication-dependent nucleosome organization (GO:0034723)2.55948574
119DNA replication-dependent nucleosome assembly (GO:0006335)2.55948574
1207-methylguanosine RNA capping (GO:0009452)2.55027540
121RNA capping (GO:0036260)2.55027540
122NADPH regeneration (GO:0006740)2.53110647
123formation of translation preinitiation complex (GO:0001731)2.52126605
124nucleotide-excision repair, DNA gap filling (GO:0006297)2.51985715
125neural tube formation (GO:0001841)2.49350504
126regulation of SMAD protein import into nucleus (GO:0060390)2.47099683
127negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.46737082
128negative regulation of sister chromatid segregation (GO:0033046)2.46737082
129negative regulation of mitotic sister chromatid separation (GO:2000816)2.46737082
130negative regulation of mitotic sister chromatid segregation (GO:0033048)2.46737082
131protein K11-linked ubiquitination (GO:0070979)2.46475970
132germ cell migration (GO:0008354)2.45179483
133positive regulation of histone H3-K4 methylation (GO:0051571)2.44814461
134embryonic process involved in female pregnancy (GO:0060136)2.44431930
135ribosomal small subunit assembly (GO:0000028)2.43765957
136positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.41446337
137IMP biosynthetic process (GO:0006188)2.39503202
138positive regulation of actin filament depolymerization (GO:0030836)2.38639262
139negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.38112585
140antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.37927259
141negative regulation of chromosome segregation (GO:0051985)2.37435801
142regulation of rhodopsin mediated signaling pathway (GO:0022400)2.37156242
143kinetochore organization (GO:0051383)2.36544861
144establishment of chromosome localization (GO:0051303)2.36502017
145DNA topological change (GO:0006265)2.36195792
146rhodopsin mediated signaling pathway (GO:0016056)2.35493111
147sphingoid metabolic process (GO:0046519)2.35296130
148cholesterol biosynthetic process (GO:0006695)2.34767412
149regulation of protein heterodimerization activity (GO:0043497)2.33972804
150antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.33283477
151spliceosomal tri-snRNP complex assembly (GO:0000244)2.32653453
152blastocyst development (GO:0001824)2.32286187
153positive regulation of SMAD protein import into nucleus (GO:0060391)2.31735733
154positive regulation of ligase activity (GO:0051351)2.31372786
155fatty acid elongation (GO:0030497)2.31018754
156regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.30069122
157regulation of mitotic spindle checkpoint (GO:1903504)2.30069122
158regulation of mitotic metaphase/anaphase transition (GO:0030071)2.29030098
159cotranslational protein targeting to membrane (GO:0006613)2.28660432
160detection of bacterium (GO:0016045)2.28148884
161DNA integration (GO:0015074)2.27999842
162cullin deneddylation (GO:0010388)2.26691008
163positive regulation of cell size (GO:0045793)2.26613022
164de novo protein folding (GO:0006458)2.26364956
165IMP metabolic process (GO:0046040)2.26243270
166regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.25756638
167ganglion development (GO:0061548)2.25393103

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.60970831
2E2F7_22180533_ChIP-Seq_HELA_Human4.46014601
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.56163071
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.32103002
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.10928332
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.10036586
7ELK1_19687146_ChIP-ChIP_HELA_Human3.05604288
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.97577532
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.86097101
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82128476
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.82102792
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.73396780
13ZNF274_21170338_ChIP-Seq_K562_Hela2.70137966
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50631967
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44758852
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.41696224
17EWS_26573619_Chip-Seq_HEK293_Human2.37163461
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34074133
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33830303
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.31679780
21FUS_26573619_Chip-Seq_HEK293_Human2.29792210
22* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.20978054
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20309066
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19299517
25VDR_23849224_ChIP-Seq_CD4+_Human2.14924257
26ETS1_20019798_ChIP-Seq_JURKAT_Human2.14707400
27IGF1R_20145208_ChIP-Seq_DFB_Human2.14348245
28HOXB4_20404135_ChIP-ChIP_EML_Mouse2.13307138
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.12823271
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10732558
31RBPJ_22232070_ChIP-Seq_NCS_Mouse2.07858071
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.06363199
33TAF15_26573619_Chip-Seq_HEK293_Human1.98736313
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97414440
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95751813
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94444263
37XRN2_22483619_ChIP-Seq_HELA_Human1.93831930
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93280079
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92136928
40DCP1A_22483619_ChIP-Seq_HELA_Human1.88584747
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.88082936
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85457379
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85420376
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84344177
45P300_19829295_ChIP-Seq_ESCs_Human1.82982742
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.82225947
47* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81116683
48VDR_22108803_ChIP-Seq_LS180_Human1.79245457
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71919727
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.71367479
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.71353815
52AR_21909140_ChIP-Seq_LNCAP_Human1.68558205
53FOXP3_21729870_ChIP-Seq_TREG_Human1.66720423
54SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.65697004
55GBX2_23144817_ChIP-Seq_PC3_Human1.63298202
56CLOCK_20551151_ChIP-Seq_293T_Human1.61685807
57* SRF_21415370_ChIP-Seq_HL-1_Mouse1.60541757
58SOX17_20123909_ChIP-Seq_XEN_Mouse1.53655565
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52764289
60MYC_18940864_ChIP-ChIP_HL60_Human1.51318419
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50922655
62GABP_19822575_ChIP-Seq_HepG2_Human1.49975856
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49367801
64TFEB_21752829_ChIP-Seq_HELA_Human1.49126408
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.47768104
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47567923
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46269708
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45588837
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45120268
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43514917
71* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41845362
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.40249422
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40056714
74* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39679607
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37133464
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36839205
77TTF2_22483619_ChIP-Seq_HELA_Human1.32609591
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32115638
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32115638
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32115638
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31964897
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.31184234
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30515461
84EGR1_19374776_ChIP-ChIP_THP-1_Human1.29361661
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27636211
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.27320394
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24657445
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24528554
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23740501
90ER_23166858_ChIP-Seq_MCF-7_Human1.23398087
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23341597
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22746643
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22437584
94IRF1_19129219_ChIP-ChIP_H3396_Human1.22146868
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21811994
96* SOX2_16153702_ChIP-ChIP_HESCs_Human1.21333965
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.20633754
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.20404566
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20226752
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.19355334
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18488921
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17398633
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16339068
104CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15728502
105ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14075114
106ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13874606
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13507486
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10926749
109* NANOG_16153702_ChIP-ChIP_HESCs_Human1.10873922
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10226753
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10196703
112NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09482208
113HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09205218
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.08963241
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08239989
116ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06819276
117* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05994140
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05981848
119SMAD4_21799915_ChIP-Seq_A2780_Human1.04382241
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04282033
121SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02432084
122CBP_20019798_ChIP-Seq_JUKART_Human1.02103730
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02103730
124GATA1_22025678_ChIP-Seq_K562_Human1.02064503
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.00407625
126SOX2_19829295_ChIP-Seq_ESCs_Human1.00270322
127NANOG_19829295_ChIP-Seq_ESCs_Human1.00270322
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99391267
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99242542
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98404478
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97555407
132SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97459752
133TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96796408
134PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96266187
135TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95838902
136SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95786396
137NANOG_18555785_Chip-Seq_ESCs_Mouse0.95524220
138* NANOG_21062744_ChIP-ChIP_HESCs_Human0.95013732
139THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94737630
140NFE2_27457419_Chip-Seq_LIVER_Mouse0.93444757
141EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93132656
142AR_25329375_ChIP-Seq_VCAP_Human0.92828540
143FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92681836
144SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92432043
145SALL4_22934838_ChIP-ChIP_CD34+_Human0.91541043
146GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91075971
147IRF8_21731497_ChIP-ChIP_J774_Mouse0.89999849
148SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85731136
149NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85257295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage3.05304106
2MP0008877_abnormal_DNA_methylation2.67958844
3MP0006072_abnormal_retinal_apoptosis2.67414332
4MP0005408_hypopigmentation2.55860291
5MP0002009_preneoplasia2.53702483
6MP0008007_abnormal_cellular_replicative2.53556885
7MP0003806_abnormal_nucleotide_metabolis2.41651653
8MP0009697_abnormal_copulation2.38347368
9MP0004957_abnormal_blastocyst_morpholog2.28285204
10MP0003693_abnormal_embryo_hatching2.12478387
11MP0001529_abnormal_vocalization2.11281222
12MP0005551_abnormal_eye_electrophysiolog2.06292742
13MP0008057_abnormal_DNA_replication1.98330561
14MP0003890_abnormal_embryonic-extraembry1.97387900
15MP0004782_abnormal_surfactant_physiolog1.90821567
16MP0005253_abnormal_eye_physiology1.89656034
17MP0001293_anophthalmia1.83937765
18MP0002102_abnormal_ear_morphology1.83767543
19MP0004147_increased_porphyrin_level1.75475652
20MP0000537_abnormal_urethra_morphology1.74811766
21MP0002938_white_spotting1.74289850
22MP0001879_abnormal_lymphatic_vessel1.73876379
23MP0005367_renal/urinary_system_phenotyp1.73460533
24MP0000516_abnormal_urinary_system1.73460533
25MP0003077_abnormal_cell_cycle1.71689618
26MP0010386_abnormal_urinary_bladder1.70270196
27MP0010094_abnormal_chromosome_stability1.69457381
28MP0000569_abnormal_digit_pigmentation1.69152171
29MP0008932_abnormal_embryonic_tissue1.69075344
30MP0003950_abnormal_plasma_membrane1.61912352
31MP0008058_abnormal_DNA_repair1.58704422
32MP0002234_abnormal_pharynx_morphology1.56652879
33MP0001346_abnormal_lacrimal_gland1.54867750
34MP0003567_abnormal_fetal_cardiomyocyte1.49501942
35MP0002166_altered_tumor_susceptibility1.49243076
36MP0005195_abnormal_posterior_eye1.45296615
37MP0005220_abnormal_exocrine_pancreas1.44947308
38MP0002736_abnormal_nociception_after1.43274212
39MP0002233_abnormal_nose_morphology1.42633519
40MP0005391_vision/eye_phenotype1.42026796
41MP0010352_gastrointestinal_tract_polyps1.41187470
42MP0010030_abnormal_orbit_morphology1.39493767
43MP0001730_embryonic_growth_arrest1.36487748
44MP0005084_abnormal_gallbladder_morpholo1.35768567
45MP0005394_taste/olfaction_phenotype1.35428591
46MP0005499_abnormal_olfactory_system1.35428591
47MP0001542_abnormal_bone_strength1.34962830
48MP0003718_maternal_effect1.33648012
49MP0000647_abnormal_sebaceous_gland1.33173591
50MP0003119_abnormal_digestive_system1.32181901
51MP0002638_abnormal_pupillary_reflex1.32024052
52MP0010234_abnormal_vibrissa_follicle1.31086107
53MP0003786_premature_aging1.29800818
54MP0003111_abnormal_nucleus_morphology1.28664278
55MP0001286_abnormal_eye_development1.27020001
56MP0002163_abnormal_gland_morphology1.25731586
57MP0005187_abnormal_penis_morphology1.25361793
58MP0003136_yellow_coat_color1.24155723
59MP0002132_abnormal_respiratory_system1.23806718
60MP0003787_abnormal_imprinting1.20386615
61MP0009053_abnormal_anal_canal1.20329155
62MP0002210_abnormal_sex_determination1.20227920
63MP0003943_abnormal_hepatobiliary_system1.19850633
64MP0003937_abnormal_limbs/digits/tail_de1.19382479
65MP0000350_abnormal_cell_proliferation1.19048144
66MP0001929_abnormal_gametogenesis1.18906433
67MP0001697_abnormal_embryo_size1.18158650
68MP0002877_abnormal_melanocyte_morpholog1.17934727
69MP0000778_abnormal_nervous_system1.17712329
70MP0009384_cardiac_valve_regurgitation1.15102488
71MP0005623_abnormal_meninges_morphology1.14466297
72MP0003755_abnormal_palate_morphology1.14396110
73MP0003011_delayed_dark_adaptation1.14120219
74MP0001324_abnormal_eye_pigmentation1.13455279
75MP0003186_abnormal_redox_activity1.13272340
76MP0003941_abnormal_skin_development1.13072865
77MP0002697_abnormal_eye_size1.11854640
78MP0010678_abnormal_skin_adnexa1.10101101
79MP0004264_abnormal_extraembryonic_tissu1.09682958
80MP0010307_abnormal_tumor_latency1.08866074
81MP0000462_abnormal_digestive_system1.08799233
82MP0000653_abnormal_sex_gland1.08184836
83MP0002254_reproductive_system_inflammat1.05858139
84MP0002282_abnormal_trachea_morphology1.03757534
85MP0000049_abnormal_middle_ear1.03038568
86MP0000358_abnormal_cell_content/1.01820937
87MP0001145_abnormal_male_reproductive1.01067220
88MP0004272_abnormal_basement_membrane1.00518122
89MP0000427_abnormal_hair_cycle0.99862834
90MP0009379_abnormal_foot_pigmentation0.99246379
91MP0001984_abnormal_olfaction0.99175058
92MP0000631_abnormal_neuroendocrine_gland0.99064930
93MP0001672_abnormal_embryogenesis/_devel0.98432529
94MP0005380_embryogenesis_phenotype0.98432529
95MP0002111_abnormal_tail_morphology0.98114840
96MP0002177_abnormal_outer_ear0.95342858
97MP0009703_decreased_birth_body0.95020258
98MP0002085_abnormal_embryonic_tissue0.94964446
99MP0002332_abnormal_exercise_endurance0.93293632
100MP0002092_abnormal_eye_morphology0.92446087
101MP0002084_abnormal_developmental_patter0.91694792
102MP0002751_abnormal_autonomic_nervous0.91496234
103MP0002277_abnormal_respiratory_mucosa0.90271207
104MP0001485_abnormal_pinna_reflex0.89873872
105MP0002080_prenatal_lethality0.89534083
106MP0001119_abnormal_female_reproductive0.89180624
107MP0006276_abnormal_autonomic_nervous0.88138842
108MP0000566_synostosis0.87826480
109MP0002090_abnormal_vision0.87696281
110MP0000372_irregular_coat_pigmentation0.87262939
111MP0000490_abnormal_crypts_of0.86971729
112MP0006292_abnormal_olfactory_placode0.86784023
113MP0005395_other_phenotype0.85843405
114MP0003984_embryonic_growth_retardation0.85811366
115MP0001299_abnormal_eye_distance/0.85701134
116MP0000465_gastrointestinal_hemorrhage0.85660617
117MP0002095_abnormal_skin_pigmentation0.85151561
118MP0002088_abnormal_embryonic_growth/wei0.83408346
119MP0004142_abnormal_muscle_tone0.82956253
120MP0003935_abnormal_craniofacial_develop0.79836160
121MP0002006_tumorigenesis0.79489577
122MP0006035_abnormal_mitochondrial_morpho0.79299182
123MP0003121_genomic_imprinting0.78646254
124MP0003221_abnormal_cardiomyocyte_apopto0.77967401
125MP0002160_abnormal_reproductive_system0.77524154
126MP0003705_abnormal_hypodermis_morpholog0.77339703
127MP0003698_abnormal_male_reproductive0.76863838
128MP0004133_heterotaxia0.76686154
129MP0003861_abnormal_nervous_system0.76342065
130MP0004197_abnormal_fetal_growth/weight/0.76185354
131MP0005379_endocrine/exocrine_gland_phen0.75277152
132MP0005248_abnormal_Harderian_gland0.74118987
133MP0000313_abnormal_cell_death0.73776593
134MP0000383_abnormal_hair_follicle0.71844324
135MP0008789_abnormal_olfactory_epithelium0.71729353
136MP0002098_abnormal_vibrissa_morphology0.69476815
137MP0005671_abnormal_response_to0.69001069
138MP0010368_abnormal_lymphatic_system0.68674791
139MP0005389_reproductive_system_phenotype0.67001436

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.12169266
2Colon cancer (HP:0003003)3.80126438
3Abnormal rod and cone electroretinograms (HP:0008323)3.46074436
4Stenosis of the external auditory canal (HP:0000402)3.40113506
5Birth length less than 3rd percentile (HP:0003561)3.38655046
6Abnormality of cochlea (HP:0000375)3.36894467
7Supernumerary spleens (HP:0009799)3.28145056
8Hematochezia (HP:0002573)3.27111096
9Hypothermia (HP:0002045)3.24469149
10Autoamputation (HP:0001218)3.21712425
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.21564784
12Volvulus (HP:0002580)3.16778794
13Severe visual impairment (HP:0001141)3.08890794
14Pancreatic islet-cell hyperplasia (HP:0004510)3.05607406
15Increased serum pyruvate (HP:0003542)3.04714840
16Abnormality of glycolysis (HP:0004366)3.04714840
17Morphological abnormality of the inner ear (HP:0011390)3.03611505
18Ependymoma (HP:0002888)3.01870348
19Carpal bone hypoplasia (HP:0001498)3.00361209
20Hypoplasia of the capital femoral epiphysis (HP:0003090)2.94111738
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.93144370
22Abnormality of the ileum (HP:0001549)2.89756551
23Meckel diverticulum (HP:0002245)2.88775263
24Abnormality of chromosome stability (HP:0003220)2.87614084
25Bony spicule pigmentary retinopathy (HP:0007737)2.87095733
26Chromsome breakage (HP:0040012)2.87006104
27Hypoplastic pelvis (HP:0008839)2.84173214
28Abnormality of the labia minora (HP:0012880)2.78331948
29Abnormal lung lobation (HP:0002101)2.73968773
30Posterior subcapsular cataract (HP:0007787)2.69168299
31Small epiphyses (HP:0010585)2.68864113
32Methylmalonic acidemia (HP:0002912)2.66619054
33Medial flaring of the eyebrow (HP:0010747)2.61632062
34Abnormality of endocrine pancreas physiology (HP:0012093)2.61537810
35Abnormality of the pancreatic islet cells (HP:0006476)2.61537810
36Microretrognathia (HP:0000308)2.61524658
37Hypoglycemic seizures (HP:0002173)2.52910044
38Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.51061812
39Absent epiphyses (HP:0010577)2.51061812
40Abnormality of abdominal situs (HP:0011620)2.48886570
41Abdominal situs inversus (HP:0003363)2.48886570
42Abnormality of the preputium (HP:0100587)2.44149943
43Abnormality of midbrain morphology (HP:0002418)2.44061949
44Molar tooth sign on MRI (HP:0002419)2.44061949
45Progressive inability to walk (HP:0002505)2.39451908
463-Methylglutaconic aciduria (HP:0003535)2.38237292
47Pendular nystagmus (HP:0012043)2.37998803
48Hypoglycemic coma (HP:0001325)2.32689044
49Abnormality of macular pigmentation (HP:0008002)2.32175800
50Nephronophthisis (HP:0000090)2.30693032
51Small intestinal stenosis (HP:0012848)2.29398141
52Duodenal stenosis (HP:0100867)2.29398141
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28070636
54Congenital primary aphakia (HP:0007707)2.23894469
55Abnormality of the duodenum (HP:0002246)2.21828604
56Cutaneous melanoma (HP:0012056)2.21684070
57Agnosia (HP:0010524)2.20396021
58Nephrogenic diabetes insipidus (HP:0009806)2.18949171
59Irregular epiphyses (HP:0010582)2.18428137
60Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.14055483
61Abolished electroretinogram (ERG) (HP:0000550)2.13254537
62Central scotoma (HP:0000603)2.11732104
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.10680184
64Ovarian neoplasm (HP:0100615)2.10309425
65Chorioretinal atrophy (HP:0000533)2.10202064
66Genital tract atresia (HP:0001827)2.09916865
67Gait imbalance (HP:0002141)2.09555252
68Thyroid carcinoma (HP:0002890)2.09059994
69Irregular vertebral endplates (HP:0003301)2.08431841
70Glioma (HP:0009733)2.06440201
71Methylmalonic aciduria (HP:0012120)2.05300511
72Medulloblastoma (HP:0002885)2.04880405
73Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03907517
74Female pseudohermaphroditism (HP:0010458)2.03710865
75Sloping forehead (HP:0000340)2.02821060
76Vertebral arch anomaly (HP:0008438)2.02450345
77Vaginal atresia (HP:0000148)2.01567926
78Embryonal renal neoplasm (HP:0011794)2.01245666
79Increased CSF lactate (HP:0002490)2.00900815
80Visceral angiomatosis (HP:0100761)1.99073654
81Nephroblastoma (Wilms tumor) (HP:0002667)1.98991356
82Severe Myopia (HP:0011003)1.97750702
83Papillary thyroid carcinoma (HP:0002895)1.97619493
84Pancreatic cysts (HP:0001737)1.95908441
85Intestinal atresia (HP:0011100)1.94925192
86Postnatal microcephaly (HP:0005484)1.94449330
87Breast hypoplasia (HP:0003187)1.94058134
88Neoplasm of the adrenal cortex (HP:0100641)1.93924287
89Patellar aplasia (HP:0006443)1.93211435
90Renal hypoplasia (HP:0000089)1.93067015
91Cortical dysplasia (HP:0002539)1.92180572
92Breast carcinoma (HP:0003002)1.91887599
93Progressive macrocephaly (HP:0004481)1.90150121
94Abnormality of the renal medulla (HP:0100957)1.89765323
95Hemangiomatosis (HP:0007461)1.89565289
96Bifid tongue (HP:0010297)1.88640498
97Pigmentary retinal degeneration (HP:0001146)1.88048332
98Heterochromia iridis (HP:0001100)1.87596425
99Acute necrotizing encephalopathy (HP:0006965)1.87273190
100Absent radius (HP:0003974)1.85689679
101Short tibia (HP:0005736)1.83169094
102Bile duct proliferation (HP:0001408)1.83047750
103Abnormal biliary tract physiology (HP:0012439)1.83047750
104Postaxial hand polydactyly (HP:0001162)1.82953419
105Increased hepatocellular lipid droplets (HP:0006565)1.82685906
106Aplasia/hypoplasia of the humerus (HP:0006507)1.81998050
107Neoplasm of the adrenal gland (HP:0100631)1.81254217
108Hypoplastic labia majora (HP:0000059)1.80860148
109Aplasia/Hypoplasia of the fovea (HP:0008060)1.79531731
110Hypoplasia of the fovea (HP:0007750)1.79531731
111Congenital, generalized hypertrichosis (HP:0004540)1.78043620
112Optic nerve hypoplasia (HP:0000609)1.77779999
113Decreased testicular size (HP:0008734)1.77551222
114Restlessness (HP:0000711)1.77078682
115Aplasia/Hypoplasia of the tibia (HP:0005772)1.75738261
116Abnormality of macrophages (HP:0004311)1.75299057
117Amaurosis fugax (HP:0100576)1.74040596
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72979863
119Ascites (HP:0001541)1.72931736
120Abnormality of the anterior horn cell (HP:0006802)1.72463698
121Degeneration of anterior horn cells (HP:0002398)1.72463698
122Neoplasm of the oral cavity (HP:0100649)1.71601552
123Clubbing of toes (HP:0100760)1.71558082
124Dandy-Walker malformation (HP:0001305)1.71455508
125Hyperinsulinemic hypoglycemia (HP:0000825)1.71283981
126Abnormality of the vasculature of the conjunctiva (HP:0008054)1.71187582
127Aplasia involving forearm bones (HP:0009822)1.71009166
128Absent forearm bone (HP:0003953)1.71009166
129Astigmatism (HP:0000483)1.70689986
130Esophageal varix (HP:0002040)1.70164065
131Acute encephalopathy (HP:0006846)1.69645919
132Gonadotropin excess (HP:0000837)1.68932678
133Oculomotor apraxia (HP:0000657)1.68789606
134Primary adrenal insufficiency (HP:0008207)1.68753285
135Triphalangeal thumb (HP:0001199)1.68705298
136Median cleft lip (HP:0000161)1.68650687
137Preaxial hand polydactyly (HP:0001177)1.68350372
138Aplasia/Hypoplasia of the patella (HP:0006498)1.68243620
139Pancreatic fibrosis (HP:0100732)1.67824915
140Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.67335425
141Abnormal protein N-linked glycosylation (HP:0012347)1.67335425
142Abnormal protein glycosylation (HP:0012346)1.67335425
143Abnormal glycosylation (HP:0012345)1.67335425
144Hyperglycinemia (HP:0002154)1.67083424
145Abnormal biliary tract morphology (HP:0012440)1.67062857
146Septo-optic dysplasia (HP:0100842)1.66252078
147Proximal placement of thumb (HP:0009623)1.66164402
148Portal hypertension (HP:0001409)1.65671394
149Rhabdomyosarcoma (HP:0002859)1.65141959
150Mitochondrial inheritance (HP:0001427)1.65081101
151Asplenia (HP:0001746)1.63475111
152Drooling (HP:0002307)1.63453411
153Small hand (HP:0200055)1.62998857
154Neoplasm of the colon (HP:0100273)1.62971558
155Epiphyseal stippling (HP:0010655)1.62539263
156Anencephaly (HP:0002323)1.62458533
157Sclerocornea (HP:0000647)1.62320707
158Gonadal dysgenesis (HP:0000133)1.61693290
159Rectal fistula (HP:0100590)1.61514120
160Rectovaginal fistula (HP:0000143)1.61514120
161Deviation of the thumb (HP:0009603)1.61312239
162Tubular atrophy (HP:0000092)1.60989491
163Scotoma (HP:0000575)1.60785182
164Abnormality of the vertebral endplates (HP:0005106)1.60604072
165Testicular neoplasm (HP:0010788)1.60577480
166Attenuation of retinal blood vessels (HP:0007843)1.60067605
167Glossoptosis (HP:0000162)1.59418757
168Adrenal hypoplasia (HP:0000835)1.59305364
169Type I transferrin isoform profile (HP:0003642)1.58353308
170Cutis marmorata (HP:0000965)1.58031737
171Keratoconus (HP:0000563)1.56576584
172Increased corneal curvature (HP:0100692)1.56576584
173Astrocytoma (HP:0009592)1.56211350
174Abnormality of the astrocytes (HP:0100707)1.56211350
175Oligodactyly (hands) (HP:0001180)1.56202744
176True hermaphroditism (HP:0010459)1.54924790
177Short humerus (HP:0005792)1.54269118

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.16944064
2SCYL23.09936238
3NUAK12.92589561
4SRPK12.78146744
5INSRR2.77717553
6FRK2.71478891
7MAP4K22.63139854
8MST42.58391178
9EIF2AK32.58358729
10TRIM282.47982155
11TNIK2.41872839
12DYRK32.36132344
13EIF2AK12.31815688
14LIMK12.29806670
15ACVR1B2.27824971
16PBK2.18109638
17WEE12.14167556
18LMTK22.07313099
19BRSK21.95452882
20PASK1.93934055
21BCR1.93111764
22LATS11.71142329
23DYRK21.67343606
24MKNK11.65827923
25FLT31.57266163
26DYRK1B1.56813997
27MAP3K41.51034709
28VRK21.50444626
29TGFBR11.49443403
30PRKG21.48588277
31NLK1.48187617
32ERBB31.45311398
33PLK31.45234073
34STK38L1.43710290
35YES11.42838515
36RPS6KB21.40906264
37NEK11.35985658
38GRK11.33938301
39NME21.32344477
40BRD41.31913713
41ZAK1.29490964
42CSNK1G31.26771142
43CASK1.24590658
44RPS6KA41.21612646
45TAF11.19847281
46FGFR21.17293697
47MAP2K71.14338323
48PNCK1.13943050
49LRRK21.10201956
50RPS6KA51.05609858
51TSSK61.03405107
52KDR1.03332554
53STK101.01933149
54VRK11.00547539
55EPHA21.00224256
56STK30.99333446
57CSNK1A1L0.98848113
58MELK0.97045254
59MET0.94328180
60TIE10.92221141
61PIM20.90804959
62TLK10.88383200
63CSNK1G10.87909090
64MKNK20.87165506
65UHMK10.82711068
66PLK10.78388349
67AURKA0.76422624
68JAK30.76003110
69ATM0.74555437
70AURKB0.71015483
71CDK80.70005207
72EPHB20.69609473
73KSR10.67849861
74CCNB10.67420442
75CHEK20.67053105
76TTK0.65500019
77WNK30.65363222
78EIF2AK20.63427266
79CDK70.63382171
80STK40.62685316
81TESK10.62040775
82MAP3K140.60704724
83NEK20.60483124
84ERBB40.60215454
85PAK40.60134809
86PLK20.59831086
87PIM10.59363008
88CDK30.58492613
89BMPR1B0.57276665
90PKN10.57114642
91TESK20.55695312
92AKT30.55114102
93PDK20.55073095
94CSNK1G20.55007724
95RAF10.54926063
96MAP3K80.54105232
97FER0.53734274
98MARK30.52928178
99PRKCI0.52713632
100ADRBK20.50858282
101CHEK10.50499032
102BRSK10.50002295
103TRPM70.49872613
104MAP3K120.48001937
105CDC70.47652938
106PRKCG0.44266162
107OXSR10.43941732
108STK160.43766179
109CDK140.43751035
110CDK60.43152900
111CLK10.40483783
112* CSNK2A10.40454857
113MAP2K20.40385403
114MAPKAPK20.39260091
115STK390.37754202
116PAK10.37455051
117PLK40.37105447
118BRAF0.36539847
119PRKCE0.36200479
120CSNK1E0.35434166
121PAK30.35358400
122ATR0.34645549
123DYRK1A0.33930930
124MAPK130.33773270
125ARAF0.33216758
126CSNK1D0.32932302
127ROCK20.32629128
128TEC0.32122810
129CSNK2A20.31902462
130TYK20.31527807
131STK240.31013360
132MARK10.29293801
133FGFR10.29133943
134CDK10.28917291
135PRKACB0.27210655
136CSNK1A10.23590493

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.57014652
2Proteasome_Homo sapiens_hsa030503.01289546
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.94681196
4Spliceosome_Homo sapiens_hsa030402.68196573
5RNA polymerase_Homo sapiens_hsa030202.51703595
6Mismatch repair_Homo sapiens_hsa034302.44106485
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.36606807
8Systemic lupus erythematosus_Homo sapiens_hsa053222.12802620
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11128337
10Phototransduction_Homo sapiens_hsa047442.10948534
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.08786038
12Cell cycle_Homo sapiens_hsa041102.04003103
13DNA replication_Homo sapiens_hsa030301.98086035
14Propanoate metabolism_Homo sapiens_hsa006401.96825581
15Folate biosynthesis_Homo sapiens_hsa007901.94136765
16Ribosome_Homo sapiens_hsa030101.81874918
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.73079866
18Base excision repair_Homo sapiens_hsa034101.70115134
19Nucleotide excision repair_Homo sapiens_hsa034201.65790843
20RNA transport_Homo sapiens_hsa030131.65395037
21Sphingolipid metabolism_Homo sapiens_hsa006001.64317780
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.64061888
23Legionellosis_Homo sapiens_hsa051341.62052285
24Non-homologous end-joining_Homo sapiens_hsa034501.55980468
25Pyrimidine metabolism_Homo sapiens_hsa002401.53596719
26Vibrio cholerae infection_Homo sapiens_hsa051101.52496981
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51559190
28Selenocompound metabolism_Homo sapiens_hsa004501.50008283
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45610360
30Basal transcription factors_Homo sapiens_hsa030221.41399844
31Sulfur metabolism_Homo sapiens_hsa009201.34298140
32RNA degradation_Homo sapiens_hsa030181.32301357
33Fatty acid elongation_Homo sapiens_hsa000621.31493404
34Viral carcinogenesis_Homo sapiens_hsa052031.30812745
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27662383
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.25130990
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23081367
38Butanoate metabolism_Homo sapiens_hsa006501.21080038
39Phagosome_Homo sapiens_hsa041451.20795982
40Caffeine metabolism_Homo sapiens_hsa002321.17698187
41p53 signaling pathway_Homo sapiens_hsa041151.16122019
42Oocyte meiosis_Homo sapiens_hsa041141.14943636
43Alcoholism_Homo sapiens_hsa050341.13649610
44Steroid biosynthesis_Homo sapiens_hsa001001.11808340
45Epstein-Barr virus infection_Homo sapiens_hsa051691.03617469
46One carbon pool by folate_Homo sapiens_hsa006701.02422903
47Homologous recombination_Homo sapiens_hsa034401.02115852
48Histidine metabolism_Homo sapiens_hsa003401.01700749
49Huntingtons disease_Homo sapiens_hsa050161.00644988
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97641495
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92165477
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92134834
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89358986
54N-Glycan biosynthesis_Homo sapiens_hsa005100.89017606
55Hedgehog signaling pathway_Homo sapiens_hsa043400.83452438
56Hippo signaling pathway_Homo sapiens_hsa043900.82871711
57Pentose phosphate pathway_Homo sapiens_hsa000300.81637586
58Purine metabolism_Homo sapiens_hsa002300.81486627
59Colorectal cancer_Homo sapiens_hsa052100.81402055
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74954637
61Antigen processing and presentation_Homo sapiens_hsa046120.72907724
62Regulation of autophagy_Homo sapiens_hsa041400.72734425
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72563882
64Apoptosis_Homo sapiens_hsa042100.72428497
65Ether lipid metabolism_Homo sapiens_hsa005650.71719688
66Pyruvate metabolism_Homo sapiens_hsa006200.69493235
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.68192290
68Nicotine addiction_Homo sapiens_hsa050330.67551572
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67458743
70Rheumatoid arthritis_Homo sapiens_hsa053230.67179466
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66809387
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65399839
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65010355
74Viral myocarditis_Homo sapiens_hsa054160.63447134
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62079120
76Fatty acid metabolism_Homo sapiens_hsa012120.61081848
77Alzheimers disease_Homo sapiens_hsa050100.60868234
78Tight junction_Homo sapiens_hsa045300.60832817
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60474566
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60072486
81Peroxisome_Homo sapiens_hsa041460.59422656
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58523670
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58474059
84Prostate cancer_Homo sapiens_hsa052150.58460725
85Shigellosis_Homo sapiens_hsa051310.57794491
86Thyroid cancer_Homo sapiens_hsa052160.56534365
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.55100380
88Arginine and proline metabolism_Homo sapiens_hsa003300.54914564
89Herpes simplex infection_Homo sapiens_hsa051680.54134744
90Basal cell carcinoma_Homo sapiens_hsa052170.53079713
91MicroRNAs in cancer_Homo sapiens_hsa052060.51926894
92Small cell lung cancer_Homo sapiens_hsa052220.51124405
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50681455
94Collecting duct acid secretion_Homo sapiens_hsa049660.50177990
95mRNA surveillance pathway_Homo sapiens_hsa030150.49752884
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49285542
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47294534
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47169950
99Fanconi anemia pathway_Homo sapiens_hsa034600.46414416
100Circadian rhythm_Homo sapiens_hsa047100.45586514
101Glutathione metabolism_Homo sapiens_hsa004800.45515198
102Biosynthesis of amino acids_Homo sapiens_hsa012300.44895278
103beta-Alanine metabolism_Homo sapiens_hsa004100.44849818
104Pertussis_Homo sapiens_hsa051330.42610632
105Tryptophan metabolism_Homo sapiens_hsa003800.42292822
106Allograft rejection_Homo sapiens_hsa053300.41922808
107Parkinsons disease_Homo sapiens_hsa050120.41599374
108Oxidative phosphorylation_Homo sapiens_hsa001900.41557432
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41312270
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.40192299
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39750651
112Renal cell carcinoma_Homo sapiens_hsa052110.38348736
113HTLV-I infection_Homo sapiens_hsa051660.37463937
114Hepatitis B_Homo sapiens_hsa051610.37165942
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37120940
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36281824
117Metabolic pathways_Homo sapiens_hsa011000.35774357
118Measles_Homo sapiens_hsa051620.34252612
119Adherens junction_Homo sapiens_hsa045200.33887347
120Pathways in cancer_Homo sapiens_hsa052000.32878405
121Wnt signaling pathway_Homo sapiens_hsa043100.31737110
122Lysosome_Homo sapiens_hsa041420.30608161
123Proteoglycans in cancer_Homo sapiens_hsa052050.29474975
124Asthma_Homo sapiens_hsa053100.29217918
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29200039
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28440211
127Melanoma_Homo sapiens_hsa052180.28365571
128Olfactory transduction_Homo sapiens_hsa047400.28060836
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.27739302
130TGF-beta signaling pathway_Homo sapiens_hsa043500.27446142
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.25428605
132Vitamin B6 metabolism_Homo sapiens_hsa007500.24511960
133Fatty acid degradation_Homo sapiens_hsa000710.23173125
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21169490
135Carbon metabolism_Homo sapiens_hsa012000.19959569
136Taste transduction_Homo sapiens_hsa047420.17450589
137Nitrogen metabolism_Homo sapiens_hsa009100.16043151
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15471146
139Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15305727
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13983169
141Dorso-ventral axis formation_Homo sapiens_hsa043200.13142014

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