PDCL3P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.62925557
2cullin deneddylation (GO:0010388)5.39064570
3protein deneddylation (GO:0000338)4.94033713
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27007329
5DNA deamination (GO:0045006)4.11855607
6water-soluble vitamin biosynthetic process (GO:0042364)4.08733233
7chaperone-mediated protein transport (GO:0072321)4.06187985
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.05549824
9ATP synthesis coupled proton transport (GO:0015986)4.05549824
10rRNA modification (GO:0000154)3.91948803
11regulation of cellular amino acid metabolic process (GO:0006521)3.83519153
12L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.83071151
13establishment of protein localization to mitochondrial membrane (GO:0090151)3.81542609
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.75241618
15DNA double-strand break processing (GO:0000729)3.74544316
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.59588927
17regulation of chronic inflammatory response (GO:0002676)3.57616193
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.56187723
19proline biosynthetic process (GO:0006561)3.56122531
20DNA catabolic process, exonucleolytic (GO:0000738)3.54366701
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54220337
22tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54220337
23signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.50557696
24signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.50557696
25signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.50557696
26protein neddylation (GO:0045116)3.49299260
27signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.49205519
28intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.49205519
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45086209
30exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.41427689
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37459333
32negative regulation of ligase activity (GO:0051352)3.37459333
33respiratory chain complex IV assembly (GO:0008535)3.37202078
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36820271
35rRNA methylation (GO:0031167)3.33142063
36mannosylation (GO:0097502)3.33106675
37signal transduction involved in DNA integrity checkpoint (GO:0072401)3.27628849
38signal transduction involved in DNA damage checkpoint (GO:0072422)3.27628849
39DNA damage response, detection of DNA damage (GO:0042769)3.24680296
40signal transduction involved in cell cycle checkpoint (GO:0072395)3.21489096
41L-methionine salvage (GO:0071267)3.18112944
42L-methionine biosynthetic process (GO:0071265)3.18112944
43amino acid salvage (GO:0043102)3.18112944
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16845861
45GTP biosynthetic process (GO:0006183)3.14743365
46kynurenine metabolic process (GO:0070189)3.13449964
47organelle disassembly (GO:1903008)3.13131630
48anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11940287
49protein targeting to mitochondrion (GO:0006626)3.08472943
50mitochondrial RNA metabolic process (GO:0000959)3.08293711
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.07053444
52termination of RNA polymerase III transcription (GO:0006386)3.07053444
53positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06299170
54protein-cofactor linkage (GO:0018065)3.05818239
55tRNA aminoacylation (GO:0043039)3.04950786
56amino acid activation (GO:0043038)3.04950786
57lactate metabolic process (GO:0006089)3.02308767
58tRNA aminoacylation for protein translation (GO:0006418)3.01196514
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00193118
60protein localization to mitochondrion (GO:0070585)3.00177139
61positive regulation of immune response to tumor cell (GO:0002839)2.99451229
62regulation of immune response to tumor cell (GO:0002837)2.99451229
63regulation of response to tumor cell (GO:0002834)2.99451229
64positive regulation of response to tumor cell (GO:0002836)2.99451229
65ribosome assembly (GO:0042255)2.97721552
66prenylation (GO:0097354)2.96762646
67protein prenylation (GO:0018342)2.96762646
68histone mRNA metabolic process (GO:0008334)2.93854606
69positive regulation of ligase activity (GO:0051351)2.91254840
70methionine biosynthetic process (GO:0009086)2.90859546
71protein complex biogenesis (GO:0070271)2.85345554
72tRNA metabolic process (GO:0006399)2.84894333
73respiratory electron transport chain (GO:0022904)2.84640848
74electron transport chain (GO:0022900)2.82886352
75antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.82878023
76regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.80183832
77establishment of protein localization to mitochondrion (GO:0072655)2.79187880
78peptidyl-histidine modification (GO:0018202)2.78415560
79S-adenosylmethionine metabolic process (GO:0046500)2.77525800
80regulation of cellular amine metabolic process (GO:0033238)2.77388801
81somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.75289611
82isotype switching (GO:0045190)2.75289611
83somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75289611
84branched-chain amino acid catabolic process (GO:0009083)2.73844155
85mitochondrial respiratory chain complex assembly (GO:0033108)2.72668427
86cytochrome complex assembly (GO:0017004)2.72521730
87DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.71200230
88purine nucleoside triphosphate biosynthetic process (GO:0009145)2.70399902
89aspartate family amino acid biosynthetic process (GO:0009067)2.68402241
90tRNA processing (GO:0008033)2.66917944
91positive regulation of cell cycle arrest (GO:0071158)2.66835325
92mitochondrial respiratory chain complex I assembly (GO:0032981)2.66488533
93NADH dehydrogenase complex assembly (GO:0010257)2.66488533
94mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66488533
95UTP metabolic process (GO:0046051)2.65574910
96regulation of meiosis I (GO:0060631)2.63137809
97RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63118347
98base-excision repair, AP site formation (GO:0006285)2.62509265
99regulation of ubiquitin-protein transferase activity (GO:0051438)2.58785175
100negative regulation of protein ubiquitination (GO:0031397)2.58534360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.93578745
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.53201279
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.50961008
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.98785765
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.38058490
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04231466
7VDR_23849224_ChIP-Seq_CD4+_Human2.93283440
8VDR_22108803_ChIP-Seq_LS180_Human2.90153238
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76596451
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.75323502
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.73986654
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70700952
13ELK1_19687146_ChIP-ChIP_HELA_Human2.61793568
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50585024
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.49629002
16FOXP3_21729870_ChIP-Seq_TREG_Human2.34874112
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.33085820
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29735502
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20449481
20ZNF274_21170338_ChIP-Seq_K562_Hela2.18826354
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05757100
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00106865
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.99932195
24DCP1A_22483619_ChIP-Seq_HELA_Human1.90382945
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.89809137
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89100533
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84997929
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.84413856
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84163475
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79447806
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78651462
32EWS_26573619_Chip-Seq_HEK293_Human1.58335489
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57625799
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53340431
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.52160328
36TP53_22573176_ChIP-Seq_HFKS_Human1.49297319
37MYC_18940864_ChIP-ChIP_HL60_Human1.45319520
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42232822
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42027369
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.39540476
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38403662
42P300_19829295_ChIP-Seq_ESCs_Human1.36922771
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35940410
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35410660
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.34995671
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.33750682
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33593413
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33571814
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33282715
50TAF15_26573619_Chip-Seq_HEK293_Human1.32923774
51GABP_19822575_ChIP-Seq_HepG2_Human1.31518983
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.22953171
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.19881174
54TTF2_22483619_ChIP-Seq_HELA_Human1.19787176
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.18209830
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18209830
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17401120
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15665195
59IGF1R_20145208_ChIP-Seq_DFB_Human1.12178717
60AR_20517297_ChIP-Seq_VCAP_Human1.12010394
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11887502
62FUS_26573619_Chip-Seq_HEK293_Human1.11364095
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.10134309
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.07748080
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.06219462
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06214285
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04929524
68NANOG_19829295_ChIP-Seq_ESCs_Human1.04868285
69SOX2_19829295_ChIP-Seq_ESCs_Human1.04868285
70E2F7_22180533_ChIP-Seq_HELA_Human1.03200511
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01018956
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00107696
73CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98957313
74GATA3_26560356_Chip-Seq_TH2_Human0.98001438
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97411665
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96500370
77THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95758455
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93878677
79RBPJ_21746931_ChIP-Seq_IB4_Human0.93794735
80POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92898928
81ER_23166858_ChIP-Seq_MCF-7_Human0.92864605
82GBX2_23144817_ChIP-Seq_PC3_Human0.92596418
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91653539
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91418165
85SALL4_22934838_ChIP-ChIP_CD34+_Human0.90897948
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90395500
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89861997
88GATA1_22025678_ChIP-Seq_K562_Human0.89659014
89NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89123164
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88895762
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87786301
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87542095
93SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87466885
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.87255300
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.83813614
96NCOR_22424771_ChIP-Seq_293T_Human0.83405108
97SUZ12_18555785_Chip-Seq_ESCs_Mouse0.83048788
98OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82805149
99IRF1_19129219_ChIP-ChIP_H3396_Human0.82305231
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.81882506

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.65175590
2MP0003718_maternal_effect3.18329300
3MP0008058_abnormal_DNA_repair3.05823745
4MP0003806_abnormal_nucleotide_metabolis2.86000541
5MP0002837_dystrophic_cardiac_calcinosis2.81583810
6MP0002102_abnormal_ear_morphology2.80628837
7MP0005167_abnormal_blood-brain_barrier2.70422217
8MP0002138_abnormal_hepatobiliary_system2.45016134
9MP0004145_abnormal_muscle_electrophysio2.25714077
10MP0006072_abnormal_retinal_apoptosis2.20714481
11MP0008872_abnormal_physiological_respon2.16278399
12MP0005075_abnormal_melanosome_morpholog2.09475184
13MP0005645_abnormal_hypothalamus_physiol2.02445013
14MP0003786_premature_aging1.99020734
15MP0005084_abnormal_gallbladder_morpholo1.98482715
16MP0003646_muscle_fatigue1.88691996
17MP0005646_abnormal_pituitary_gland1.84266965
18MP0001873_stomach_inflammation1.83564818
19MP0006036_abnormal_mitochondrial_physio1.82302915
20MP0002736_abnormal_nociception_after1.81052420
21MP0006292_abnormal_olfactory_placode1.80734348
22MP0008877_abnormal_DNA_methylation1.78056775
23MP0004957_abnormal_blastocyst_morpholog1.65131418
24MP0005671_abnormal_response_to1.60826444
25MP0008775_abnormal_heart_ventricle1.57587789
26MP0003724_increased_susceptibility_to1.56278596
27MP0009697_abnormal_copulation1.54654943
28MP0004215_abnormal_myocardial_fiber1.53158398
29MP0010094_abnormal_chromosome_stability1.50942626
30MP0000685_abnormal_immune_system1.50712139
31MP0001835_abnormal_antigen_presentation1.44255480
32MP0003656_abnormal_erythrocyte_physiolo1.42027401
33MP0000516_abnormal_urinary_system1.41557652
34MP0005367_renal/urinary_system_phenotyp1.41557652
35MP0004885_abnormal_endolymph1.39321668
36MP0002277_abnormal_respiratory_mucosa1.39060288
37MP0003567_abnormal_fetal_cardiomyocyte1.38731957
38MP0002160_abnormal_reproductive_system1.38267801
39MP0008875_abnormal_xenobiotic_pharmacok1.36792851
40MP0005389_reproductive_system_phenotype1.31078541
41MP0003195_calcinosis1.29746822
42MP0004036_abnormal_muscle_relaxation1.26632842
43MP0000465_gastrointestinal_hemorrhage1.26441004
44MP0001501_abnormal_sleep_pattern1.26372688
45MP0005551_abnormal_eye_electrophysiolog1.25307263
46MP0008057_abnormal_DNA_replication1.25011654
47MP0003693_abnormal_embryo_hatching1.23224519
48MP0004782_abnormal_surfactant_physiolog1.20493808
49MP0002876_abnormal_thyroid_physiology1.18919270
50MP0001968_abnormal_touch/_nociception1.18298533
51MP0002148_abnormal_hypersensitivity_rea1.17870069
52MP0001764_abnormal_homeostasis1.12697747
53MP0006035_abnormal_mitochondrial_morpho1.11591061
54MP0005332_abnormal_amino_acid1.11426543
55MP0002735_abnormal_chemical_nociception1.11262302
56MP0006276_abnormal_autonomic_nervous1.08435324
57MP0003866_abnormal_defecation1.05786129
58MP0005636_abnormal_mineral_homeostasis1.05596193
59MP0005395_other_phenotype1.05117177
60MP0009046_muscle_twitch1.03704332
61MP0004084_abnormal_cardiac_muscle1.01430113
62MP0000372_irregular_coat_pigmentation1.01003261
63MP0008995_early_reproductive_senescence1.00863925
64MP0009785_altered_susceptibility_to1.00858529
65MP0001661_extended_life_span0.99776031
66MP0003880_abnormal_central_pattern0.98230688
67MP0005253_abnormal_eye_physiology0.97503275
68MP0003186_abnormal_redox_activity0.95988647
69MP0001929_abnormal_gametogenesis0.94804986
70MP0005410_abnormal_fertilization0.94637651
71MP0001188_hyperpigmentation0.93544808
72MP0002751_abnormal_autonomic_nervous0.92905462
73MP0010368_abnormal_lymphatic_system0.91627418
74MP0003283_abnormal_digestive_organ0.89009442
75MP0002272_abnormal_nervous_system0.88823665
76MP0009764_decreased_sensitivity_to0.86876570
77MP0005000_abnormal_immune_tolerance0.86636793
78MP0001800_abnormal_humoral_immune0.85758630
79MP0001853_heart_inflammation0.85269178
80MP0009333_abnormal_splenocyte_physiolog0.83417735
81MP0001919_abnormal_reproductive_system0.83074096
82MP0006082_CNS_inflammation0.83038861
83MP0002210_abnormal_sex_determination0.82110799
84MP0001145_abnormal_male_reproductive0.81567087
85MP0005448_abnormal_energy_balance0.78629598
86MP0003011_delayed_dark_adaptation0.78283172
87MP0008932_abnormal_embryonic_tissue0.76595716
88MP0003943_abnormal_hepatobiliary_system0.75640450
89MP0001756_abnormal_urination0.75637071
90MP0000653_abnormal_sex_gland0.74705846
91MP0001986_abnormal_taste_sensitivity0.74446596
92MP0001790_abnormal_immune_system0.74340801
93MP0005387_immune_system_phenotype0.74340801
94MP0000631_abnormal_neuroendocrine_gland0.72692196
95MP0002693_abnormal_pancreas_physiology0.72021743
96MP0005319_abnormal_enzyme/_coenzyme0.68844539
97MP0003077_abnormal_cell_cycle0.67291389
98MP0002163_abnormal_gland_morphology0.66102685
99MP0000689_abnormal_spleen_morphology0.63838262
100MP0003763_abnormal_thymus_physiology0.62290357

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.08060197
2Congenital, generalized hypertrichosis (HP:0004540)3.87646928
3Lipid accumulation in hepatocytes (HP:0006561)3.69572115
4Methylmalonic acidemia (HP:0002912)3.52237583
5Increased CSF lactate (HP:0002490)3.41602722
6Mitochondrial inheritance (HP:0001427)3.35132403
7Acute necrotizing encephalopathy (HP:0006965)3.33269247
83-Methylglutaconic aciduria (HP:0003535)3.22375745
9Hepatocellular necrosis (HP:0001404)3.16559381
10Abnormality of alanine metabolism (HP:0010916)3.03000880
11Hyperalaninemia (HP:0003348)3.03000880
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.03000880
13Genetic anticipation (HP:0003743)3.02729919
14Progressive macrocephaly (HP:0004481)3.02274290
15Acute encephalopathy (HP:0006846)2.94250292
16Abnormality of methionine metabolism (HP:0010901)2.93271346
17Abnormality of the pons (HP:0007361)2.93172225
18Methylmalonic aciduria (HP:0012120)2.86226840
19Exertional dyspnea (HP:0002875)2.85883680
20Type I transferrin isoform profile (HP:0003642)2.85080613
21Abnormality of homocysteine metabolism (HP:0010919)2.84250111
22Homocystinuria (HP:0002156)2.84250111
23Constricted visual fields (HP:0001133)2.79726584
24Abnormal mitochondria in muscle tissue (HP:0008316)2.77269438
25Hepatic necrosis (HP:0002605)2.75778774
26Hypoplasia of the pons (HP:0012110)2.74334555
27Renal Fanconi syndrome (HP:0001994)2.67570449
28Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62436861
29Increased serum lactate (HP:0002151)2.56349538
30Hyperinsulinemic hypoglycemia (HP:0000825)2.56254214
31Increased intramyocellular lipid droplets (HP:0012240)2.55122252
32Abnormal protein glycosylation (HP:0012346)2.48299747
33Abnormal glycosylation (HP:0012345)2.48299747
34Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.48299747
35Abnormal protein N-linked glycosylation (HP:0012347)2.48299747
36Hypothermia (HP:0002045)2.46992719
37Lactic acidosis (HP:0003128)2.46127148
38Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.45963081
39Optic disc pallor (HP:0000543)2.43522288
40Abnormality of the vitamin B12 metabolism (HP:0004341)2.41103787
41Cerebral edema (HP:0002181)2.40339001
42Attenuation of retinal blood vessels (HP:0007843)2.40175546
43Cerebral hypomyelination (HP:0006808)2.37780065
44Abnormality of vitamin B metabolism (HP:0004340)2.37490984
45IgG deficiency (HP:0004315)2.34816447
46Abolished electroretinogram (ERG) (HP:0000550)2.34088784
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.32837896
48Thyroiditis (HP:0100646)2.28759087
49Severe combined immunodeficiency (HP:0004430)2.27643995
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27222052
51Abnormality of midbrain morphology (HP:0002418)2.24795162
52Molar tooth sign on MRI (HP:0002419)2.24795162
53Abnormal rod and cone electroretinograms (HP:0008323)2.23911152
54Hypoproteinemia (HP:0003075)2.22786188
55Palpitations (HP:0001962)2.22570041
56Abnormal albumin level (HP:0012116)2.19998617
57Hypoalbuminemia (HP:0003073)2.19998617
58Microvesicular hepatic steatosis (HP:0001414)2.17105213
59Abnormality of serum amino acid levels (HP:0003112)2.15938355
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15295889
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15295889
62Pancreatic cysts (HP:0001737)2.11405245
63Conjunctival hamartoma (HP:0100780)2.11228286
64Medial flaring of the eyebrow (HP:0010747)2.06748997
65Stenosis of the external auditory canal (HP:0000402)2.06312638
66Lethargy (HP:0001254)2.05952702
67Meckel diverticulum (HP:0002245)2.05086988
68Abnormality of the preputium (HP:0100587)2.04243035
69Abnormality of the ileum (HP:0001549)2.04008014
70Abnormality of sulfur amino acid metabolism (HP:0004339)2.02368225
71Progressive microcephaly (HP:0000253)2.00584000
72Increased muscle lipid content (HP:0009058)2.00061436
73Insulin-resistant diabetes mellitus (HP:0000831)1.97084540
74Respiratory difficulties (HP:0002880)1.96321024
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95562232
76Progressive cerebellar ataxia (HP:0002073)1.95143673
77Aplasia/Hypoplasia of the uvula (HP:0010293)1.94293168
78Abnormality of chromosome stability (HP:0003220)1.93841542
79Aplastic anemia (HP:0001915)1.93187723
80Hyperglycemia (HP:0003074)1.91545895
81CNS demyelination (HP:0007305)1.90660073
82Hypoplasia of the fovea (HP:0007750)1.89880691
83Aplasia/Hypoplasia of the fovea (HP:0008060)1.89880691
84Abnormality of eosinophils (HP:0001879)1.87884332
85Panhypogammaglobulinemia (HP:0003139)1.87153963
86Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86716702
87Pancreatic fibrosis (HP:0100732)1.86308728
88Neoplasm of the rectum (HP:0100743)1.84002125
89Hypoglycemic coma (HP:0001325)1.82782884
90Degeneration of anterior horn cells (HP:0002398)1.81791175
91Abnormality of the anterior horn cell (HP:0006802)1.81791175
92Hypoglycemic seizures (HP:0002173)1.80087437
93Metaphyseal dysplasia (HP:0100255)1.79056803
94Glycosuria (HP:0003076)1.78552431
95Abnormality of urine glucose concentration (HP:0011016)1.78552431
96Combined immunodeficiency (HP:0005387)1.78310940
97Congenital stationary night blindness (HP:0007642)1.75370904
98Neuroendocrine neoplasm (HP:0100634)1.75367455
99Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69290266
100Gaze-evoked nystagmus (HP:0000640)1.68894703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.61437757
2EIF2AK33.05398442
3TRIM282.99313551
4EIF2AK12.83285096
5NUAK12.80509331
6TLK12.53771222
7MAP3K122.48589658
8TSSK62.48098112
9TRPM72.36258508
10INSRR2.34295399
11GRK12.26102022
12MST42.20994142
13BCKDK2.09262519
14BUB12.05542582
15SRPK12.05084264
16ZAK1.83198472
17ACVR1B1.79084846
18FRK1.79024999
19TXK1.64327933
20MAP4K21.63512621
21CDK191.56631016
22NME11.52136017
23OXSR11.51179102
24PBK1.47228648
25NEK11.44629970
26BMPR1B1.44091276
27KIT1.41682876
28STK161.41529003
29TEC1.37113510
30BCR1.31478037
31PLK31.31018136
32MKNK21.29115801
33MKNK11.28125362
34FLT31.23170656
35CDK81.21064657
36FER1.20877454
37CSNK1G11.20045939
38CSNK1G31.19975201
39WNK31.17686034
40PLK41.16867652
41TAOK31.15780510
42MYLK1.15058695
43ILK1.14682249
44VRK21.11380936
45MAPKAPK51.08903605
46ADRBK21.08059570
47DAPK11.07505797
48WNK40.99484323
49CSNK1G20.97163903
50CSNK1A1L0.94702558
51PHKG20.93727299
52PHKG10.93727299
53ERBB30.93113910
54VRK10.92878579
55TGFBR10.87718117
56MAPKAPK30.86486870
57TTK0.86451133
58SIK30.82503075
59PINK10.79146052
60BMPR20.79049100
61MAP2K60.76470566
62EIF2AK20.74283671
63PLK20.71788577
64IRAK10.71004381
65PDK20.70373747
66MATK0.70005047
67EPHA30.69494383
68DYRK20.66533827
69ALK0.64331158
70CAMKK20.60455969
71FES0.56943405
72TNIK0.56265245
73BRSK20.55275357
74RPS6KA50.53693935
75PLK10.52275382
76GRK50.47669821
77PASK0.43975056
78IKBKB0.43125398
79NLK0.40061546
80CCNB10.36252961
81ADRBK10.36069742
82CSNK1A10.35616226
83OBSCN0.34380032
84CSNK2A10.33676560
85LCK0.33323908
86MINK10.32237808
87ITK0.31163585
88IGF1R0.30253573
89PRKCG0.28209580
90CAMK2A0.27723047
91GRK70.27581580
92CSNK2A20.26818085
93ATM0.26669053
94MAP4K10.25349879
95EGFR0.25282224
96CSNK1D0.24498281
97PRKCE0.24091549
98AURKB0.23985548
99DAPK20.22078014
100PRKCA0.19185582

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.67782328
2Protein export_Homo sapiens_hsa030603.41237260
3Oxidative phosphorylation_Homo sapiens_hsa001902.96364707
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.87657863
5Asthma_Homo sapiens_hsa053102.68937052
6Parkinsons disease_Homo sapiens_hsa050122.60679663
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.54584381
8RNA polymerase_Homo sapiens_hsa030202.33273044
9Type I diabetes mellitus_Homo sapiens_hsa049402.17527167
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17454354
11Allograft rejection_Homo sapiens_hsa053302.07567871
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97677147
13Basal transcription factors_Homo sapiens_hsa030221.91385309
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86704386
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.81809345
16RNA transport_Homo sapiens_hsa030131.73019678
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72389146
18Non-homologous end-joining_Homo sapiens_hsa034501.72368461
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70030125
20Autoimmune thyroid disease_Homo sapiens_hsa053201.65916632
21One carbon pool by folate_Homo sapiens_hsa006701.64697972
22Mismatch repair_Homo sapiens_hsa034301.63452640
23Homologous recombination_Homo sapiens_hsa034401.62911449
24RNA degradation_Homo sapiens_hsa030181.59870663
25Propanoate metabolism_Homo sapiens_hsa006401.59380536
26Antigen processing and presentation_Homo sapiens_hsa046121.51090444
27Phototransduction_Homo sapiens_hsa047441.46669396
28Spliceosome_Homo sapiens_hsa030401.45505600
29Alzheimers disease_Homo sapiens_hsa050101.40948458
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39738230
31Ribosome_Homo sapiens_hsa030101.36164535
32Huntingtons disease_Homo sapiens_hsa050161.31127230
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29369267
34Graft-versus-host disease_Homo sapiens_hsa053321.26290500
35Collecting duct acid secretion_Homo sapiens_hsa049661.19152200
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18527080
37Butanoate metabolism_Homo sapiens_hsa006501.17406805
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14824357
39Nucleotide excision repair_Homo sapiens_hsa034201.11433781
40Sulfur metabolism_Homo sapiens_hsa009201.11231445
41DNA replication_Homo sapiens_hsa030301.10237726
42Rheumatoid arthritis_Homo sapiens_hsa053231.08918017
43Fanconi anemia pathway_Homo sapiens_hsa034601.08138234
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02220449
45Selenocompound metabolism_Homo sapiens_hsa004501.01986765
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.01630013
47Nitrogen metabolism_Homo sapiens_hsa009101.00703566
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99962379
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96117863
50Purine metabolism_Homo sapiens_hsa002300.95315662
51Pyrimidine metabolism_Homo sapiens_hsa002400.95170911
52Regulation of autophagy_Homo sapiens_hsa041400.87167343
53Hematopoietic cell lineage_Homo sapiens_hsa046400.86534619
54Pyruvate metabolism_Homo sapiens_hsa006200.84424051
55Legionellosis_Homo sapiens_hsa051340.80546045
56Cardiac muscle contraction_Homo sapiens_hsa042600.74287893
57Mineral absorption_Homo sapiens_hsa049780.68439452
58Base excision repair_Homo sapiens_hsa034100.67895778
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67319951
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66903197
61Peroxisome_Homo sapiens_hsa041460.65096954
62Tryptophan metabolism_Homo sapiens_hsa003800.64811708
63Folate biosynthesis_Homo sapiens_hsa007900.64684366
64Primary immunodeficiency_Homo sapiens_hsa053400.63779323
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.62050363
66Glutathione metabolism_Homo sapiens_hsa004800.59511487
67Fatty acid elongation_Homo sapiens_hsa000620.59442894
68Metabolic pathways_Homo sapiens_hsa011000.59356281
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59037848
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58311243
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57014115
72Chemical carcinogenesis_Homo sapiens_hsa052040.54426159
73Linoleic acid metabolism_Homo sapiens_hsa005910.54319803
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53644060
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53552221
76Viral myocarditis_Homo sapiens_hsa054160.49566162
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48727584
78Epstein-Barr virus infection_Homo sapiens_hsa051690.47829053
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46833635
80Fat digestion and absorption_Homo sapiens_hsa049750.45756987
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40496711
82Biosynthesis of amino acids_Homo sapiens_hsa012300.39819078
83Leishmaniasis_Homo sapiens_hsa051400.39157968
84Malaria_Homo sapiens_hsa051440.38962491
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38139213
86Arginine and proline metabolism_Homo sapiens_hsa003300.38049512
87Vitamin B6 metabolism_Homo sapiens_hsa007500.37425505
88Caffeine metabolism_Homo sapiens_hsa002320.36048362
89Ether lipid metabolism_Homo sapiens_hsa005650.35338727
90mRNA surveillance pathway_Homo sapiens_hsa030150.34664776
91Steroid biosynthesis_Homo sapiens_hsa001000.34255003
92Vibrio cholerae infection_Homo sapiens_hsa051100.32515423
93Herpes simplex infection_Homo sapiens_hsa051680.30361682
94Carbon metabolism_Homo sapiens_hsa012000.30329953
95Olfactory transduction_Homo sapiens_hsa047400.28454292
96African trypanosomiasis_Homo sapiens_hsa051430.27959733
97Arginine biosynthesis_Homo sapiens_hsa002200.26971383
98Serotonergic synapse_Homo sapiens_hsa047260.26020052
99Oocyte meiosis_Homo sapiens_hsa041140.24462663
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22559879

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