

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 6.62925557 |
| 2 | cullin deneddylation (GO:0010388) | 5.39064570 |
| 3 | protein deneddylation (GO:0000338) | 4.94033713 |
| 4 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.27007329 |
| 5 | DNA deamination (GO:0045006) | 4.11855607 |
| 6 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.08733233 |
| 7 | chaperone-mediated protein transport (GO:0072321) | 4.06187985 |
| 8 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.05549824 |
| 9 | ATP synthesis coupled proton transport (GO:0015986) | 4.05549824 |
| 10 | rRNA modification (GO:0000154) | 3.91948803 |
| 11 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.83519153 |
| 12 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.83071151 |
| 13 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.81542609 |
| 14 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.75241618 |
| 15 | DNA double-strand break processing (GO:0000729) | 3.74544316 |
| 16 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.59588927 |
| 17 | regulation of chronic inflammatory response (GO:0002676) | 3.57616193 |
| 18 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.56187723 |
| 19 | proline biosynthetic process (GO:0006561) | 3.56122531 |
| 20 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.54366701 |
| 21 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.54220337 |
| 22 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.54220337 |
| 23 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.50557696 |
| 24 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.50557696 |
| 25 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.50557696 |
| 26 | protein neddylation (GO:0045116) | 3.49299260 |
| 27 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.49205519 |
| 28 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.49205519 |
| 29 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.45086209 |
| 30 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.41427689 |
| 31 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.37459333 |
| 32 | negative regulation of ligase activity (GO:0051352) | 3.37459333 |
| 33 | respiratory chain complex IV assembly (GO:0008535) | 3.37202078 |
| 34 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.36820271 |
| 35 | rRNA methylation (GO:0031167) | 3.33142063 |
| 36 | mannosylation (GO:0097502) | 3.33106675 |
| 37 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.27628849 |
| 38 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.27628849 |
| 39 | DNA damage response, detection of DNA damage (GO:0042769) | 3.24680296 |
| 40 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.21489096 |
| 41 | L-methionine salvage (GO:0071267) | 3.18112944 |
| 42 | L-methionine biosynthetic process (GO:0071265) | 3.18112944 |
| 43 | amino acid salvage (GO:0043102) | 3.18112944 |
| 44 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.16845861 |
| 45 | GTP biosynthetic process (GO:0006183) | 3.14743365 |
| 46 | kynurenine metabolic process (GO:0070189) | 3.13449964 |
| 47 | organelle disassembly (GO:1903008) | 3.13131630 |
| 48 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.11940287 |
| 49 | protein targeting to mitochondrion (GO:0006626) | 3.08472943 |
| 50 | mitochondrial RNA metabolic process (GO:0000959) | 3.08293711 |
| 51 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.07053444 |
| 52 | termination of RNA polymerase III transcription (GO:0006386) | 3.07053444 |
| 53 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.06299170 |
| 54 | protein-cofactor linkage (GO:0018065) | 3.05818239 |
| 55 | tRNA aminoacylation (GO:0043039) | 3.04950786 |
| 56 | amino acid activation (GO:0043038) | 3.04950786 |
| 57 | lactate metabolic process (GO:0006089) | 3.02308767 |
| 58 | tRNA aminoacylation for protein translation (GO:0006418) | 3.01196514 |
| 59 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.00193118 |
| 60 | protein localization to mitochondrion (GO:0070585) | 3.00177139 |
| 61 | positive regulation of immune response to tumor cell (GO:0002839) | 2.99451229 |
| 62 | regulation of immune response to tumor cell (GO:0002837) | 2.99451229 |
| 63 | regulation of response to tumor cell (GO:0002834) | 2.99451229 |
| 64 | positive regulation of response to tumor cell (GO:0002836) | 2.99451229 |
| 65 | ribosome assembly (GO:0042255) | 2.97721552 |
| 66 | prenylation (GO:0097354) | 2.96762646 |
| 67 | protein prenylation (GO:0018342) | 2.96762646 |
| 68 | histone mRNA metabolic process (GO:0008334) | 2.93854606 |
| 69 | positive regulation of ligase activity (GO:0051351) | 2.91254840 |
| 70 | methionine biosynthetic process (GO:0009086) | 2.90859546 |
| 71 | protein complex biogenesis (GO:0070271) | 2.85345554 |
| 72 | tRNA metabolic process (GO:0006399) | 2.84894333 |
| 73 | respiratory electron transport chain (GO:0022904) | 2.84640848 |
| 74 | electron transport chain (GO:0022900) | 2.82886352 |
| 75 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.82878023 |
| 76 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.80183832 |
| 77 | establishment of protein localization to mitochondrion (GO:0072655) | 2.79187880 |
| 78 | peptidyl-histidine modification (GO:0018202) | 2.78415560 |
| 79 | S-adenosylmethionine metabolic process (GO:0046500) | 2.77525800 |
| 80 | regulation of cellular amine metabolic process (GO:0033238) | 2.77388801 |
| 81 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.75289611 |
| 82 | isotype switching (GO:0045190) | 2.75289611 |
| 83 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.75289611 |
| 84 | branched-chain amino acid catabolic process (GO:0009083) | 2.73844155 |
| 85 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.72668427 |
| 86 | cytochrome complex assembly (GO:0017004) | 2.72521730 |
| 87 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.71200230 |
| 88 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.70399902 |
| 89 | aspartate family amino acid biosynthetic process (GO:0009067) | 2.68402241 |
| 90 | tRNA processing (GO:0008033) | 2.66917944 |
| 91 | positive regulation of cell cycle arrest (GO:0071158) | 2.66835325 |
| 92 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.66488533 |
| 93 | NADH dehydrogenase complex assembly (GO:0010257) | 2.66488533 |
| 94 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.66488533 |
| 95 | UTP metabolic process (GO:0046051) | 2.65574910 |
| 96 | regulation of meiosis I (GO:0060631) | 2.63137809 |
| 97 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.63118347 |
| 98 | base-excision repair, AP site formation (GO:0006285) | 2.62509265 |
| 99 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.58785175 |
| 100 | negative regulation of protein ubiquitination (GO:0031397) | 2.58534360 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.93578745 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.53201279 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.50961008 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.98785765 |
| 5 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.38058490 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.04231466 |
| 7 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.93283440 |
| 8 | VDR_22108803_ChIP-Seq_LS180_Human | 2.90153238 |
| 9 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.76596451 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.75323502 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.73986654 |
| 12 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.70700952 |
| 13 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.61793568 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.50585024 |
| 15 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.49629002 |
| 16 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.34874112 |
| 17 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.33085820 |
| 18 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.29735502 |
| 19 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.20449481 |
| 20 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.18826354 |
| 21 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.05757100 |
| 22 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.00106865 |
| 23 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.99932195 |
| 24 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.90382945 |
| 25 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.89809137 |
| 26 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.89100533 |
| 27 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.84997929 |
| 28 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.84413856 |
| 29 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.84163475 |
| 30 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.79447806 |
| 31 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.78651462 |
| 32 | EWS_26573619_Chip-Seq_HEK293_Human | 1.58335489 |
| 33 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.57625799 |
| 34 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.53340431 |
| 35 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.52160328 |
| 36 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.49297319 |
| 37 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.45319520 |
| 38 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.42232822 |
| 39 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.42027369 |
| 40 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.39540476 |
| 41 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.38403662 |
| 42 | P300_19829295_ChIP-Seq_ESCs_Human | 1.36922771 |
| 43 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.35940410 |
| 44 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.35410660 |
| 45 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.34995671 |
| 46 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.33750682 |
| 47 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.33593413 |
| 48 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.33571814 |
| 49 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.33282715 |
| 50 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.32923774 |
| 51 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.31518983 |
| 52 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.22953171 |
| 53 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.19881174 |
| 54 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.19787176 |
| 55 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.18209830 |
| 56 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.18209830 |
| 57 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.17401120 |
| 58 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.15665195 |
| 59 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.12178717 |
| 60 | AR_20517297_ChIP-Seq_VCAP_Human | 1.12010394 |
| 61 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.11887502 |
| 62 | FUS_26573619_Chip-Seq_HEK293_Human | 1.11364095 |
| 63 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.10134309 |
| 64 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.07748080 |
| 65 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.06219462 |
| 66 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.06214285 |
| 67 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.04929524 |
| 68 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.04868285 |
| 69 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.04868285 |
| 70 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.03200511 |
| 71 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.01018956 |
| 72 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.00107696 |
| 73 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.98957313 |
| 74 | GATA3_26560356_Chip-Seq_TH2_Human | 0.98001438 |
| 75 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.97411665 |
| 76 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.96500370 |
| 77 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.95758455 |
| 78 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93878677 |
| 79 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.93794735 |
| 80 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.92898928 |
| 81 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.92864605 |
| 82 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.92596418 |
| 83 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.91653539 |
| 84 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.91418165 |
| 85 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.90897948 |
| 86 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.90395500 |
| 87 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.89861997 |
| 88 | GATA1_22025678_ChIP-Seq_K562_Human | 0.89659014 |
| 89 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.89123164 |
| 90 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.88895762 |
| 91 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.87786301 |
| 92 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.87542095 |
| 93 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.87466885 |
| 94 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 0.87255300 |
| 95 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.83813614 |
| 96 | NCOR_22424771_ChIP-Seq_293T_Human | 0.83405108 |
| 97 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.83048788 |
| 98 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.82805149 |
| 99 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.82305231 |
| 100 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.81882506 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004147_increased_porphyrin_level | 4.65175590 |
| 2 | MP0003718_maternal_effect | 3.18329300 |
| 3 | MP0008058_abnormal_DNA_repair | 3.05823745 |
| 4 | MP0003806_abnormal_nucleotide_metabolis | 2.86000541 |
| 5 | MP0002837_dystrophic_cardiac_calcinosis | 2.81583810 |
| 6 | MP0002102_abnormal_ear_morphology | 2.80628837 |
| 7 | MP0005167_abnormal_blood-brain_barrier | 2.70422217 |
| 8 | MP0002138_abnormal_hepatobiliary_system | 2.45016134 |
| 9 | MP0004145_abnormal_muscle_electrophysio | 2.25714077 |
| 10 | MP0006072_abnormal_retinal_apoptosis | 2.20714481 |
| 11 | MP0008872_abnormal_physiological_respon | 2.16278399 |
| 12 | MP0005075_abnormal_melanosome_morpholog | 2.09475184 |
| 13 | MP0005645_abnormal_hypothalamus_physiol | 2.02445013 |
| 14 | MP0003786_premature_aging | 1.99020734 |
| 15 | MP0005084_abnormal_gallbladder_morpholo | 1.98482715 |
| 16 | MP0003646_muscle_fatigue | 1.88691996 |
| 17 | MP0005646_abnormal_pituitary_gland | 1.84266965 |
| 18 | MP0001873_stomach_inflammation | 1.83564818 |
| 19 | MP0006036_abnormal_mitochondrial_physio | 1.82302915 |
| 20 | MP0002736_abnormal_nociception_after | 1.81052420 |
| 21 | MP0006292_abnormal_olfactory_placode | 1.80734348 |
| 22 | MP0008877_abnormal_DNA_methylation | 1.78056775 |
| 23 | MP0004957_abnormal_blastocyst_morpholog | 1.65131418 |
| 24 | MP0005671_abnormal_response_to | 1.60826444 |
| 25 | MP0008775_abnormal_heart_ventricle | 1.57587789 |
| 26 | MP0003724_increased_susceptibility_to | 1.56278596 |
| 27 | MP0009697_abnormal_copulation | 1.54654943 |
| 28 | MP0004215_abnormal_myocardial_fiber | 1.53158398 |
| 29 | MP0010094_abnormal_chromosome_stability | 1.50942626 |
| 30 | MP0000685_abnormal_immune_system | 1.50712139 |
| 31 | MP0001835_abnormal_antigen_presentation | 1.44255480 |
| 32 | MP0003656_abnormal_erythrocyte_physiolo | 1.42027401 |
| 33 | MP0000516_abnormal_urinary_system | 1.41557652 |
| 34 | MP0005367_renal/urinary_system_phenotyp | 1.41557652 |
| 35 | MP0004885_abnormal_endolymph | 1.39321668 |
| 36 | MP0002277_abnormal_respiratory_mucosa | 1.39060288 |
| 37 | MP0003567_abnormal_fetal_cardiomyocyte | 1.38731957 |
| 38 | MP0002160_abnormal_reproductive_system | 1.38267801 |
| 39 | MP0008875_abnormal_xenobiotic_pharmacok | 1.36792851 |
| 40 | MP0005389_reproductive_system_phenotype | 1.31078541 |
| 41 | MP0003195_calcinosis | 1.29746822 |
| 42 | MP0004036_abnormal_muscle_relaxation | 1.26632842 |
| 43 | MP0000465_gastrointestinal_hemorrhage | 1.26441004 |
| 44 | MP0001501_abnormal_sleep_pattern | 1.26372688 |
| 45 | MP0005551_abnormal_eye_electrophysiolog | 1.25307263 |
| 46 | MP0008057_abnormal_DNA_replication | 1.25011654 |
| 47 | MP0003693_abnormal_embryo_hatching | 1.23224519 |
| 48 | MP0004782_abnormal_surfactant_physiolog | 1.20493808 |
| 49 | MP0002876_abnormal_thyroid_physiology | 1.18919270 |
| 50 | MP0001968_abnormal_touch/_nociception | 1.18298533 |
| 51 | MP0002148_abnormal_hypersensitivity_rea | 1.17870069 |
| 52 | MP0001764_abnormal_homeostasis | 1.12697747 |
| 53 | MP0006035_abnormal_mitochondrial_morpho | 1.11591061 |
| 54 | MP0005332_abnormal_amino_acid | 1.11426543 |
| 55 | MP0002735_abnormal_chemical_nociception | 1.11262302 |
| 56 | MP0006276_abnormal_autonomic_nervous | 1.08435324 |
| 57 | MP0003866_abnormal_defecation | 1.05786129 |
| 58 | MP0005636_abnormal_mineral_homeostasis | 1.05596193 |
| 59 | MP0005395_other_phenotype | 1.05117177 |
| 60 | MP0009046_muscle_twitch | 1.03704332 |
| 61 | MP0004084_abnormal_cardiac_muscle | 1.01430113 |
| 62 | MP0000372_irregular_coat_pigmentation | 1.01003261 |
| 63 | MP0008995_early_reproductive_senescence | 1.00863925 |
| 64 | MP0009785_altered_susceptibility_to | 1.00858529 |
| 65 | MP0001661_extended_life_span | 0.99776031 |
| 66 | MP0003880_abnormal_central_pattern | 0.98230688 |
| 67 | MP0005253_abnormal_eye_physiology | 0.97503275 |
| 68 | MP0003186_abnormal_redox_activity | 0.95988647 |
| 69 | MP0001929_abnormal_gametogenesis | 0.94804986 |
| 70 | MP0005410_abnormal_fertilization | 0.94637651 |
| 71 | MP0001188_hyperpigmentation | 0.93544808 |
| 72 | MP0002751_abnormal_autonomic_nervous | 0.92905462 |
| 73 | MP0010368_abnormal_lymphatic_system | 0.91627418 |
| 74 | MP0003283_abnormal_digestive_organ | 0.89009442 |
| 75 | MP0002272_abnormal_nervous_system | 0.88823665 |
| 76 | MP0009764_decreased_sensitivity_to | 0.86876570 |
| 77 | MP0005000_abnormal_immune_tolerance | 0.86636793 |
| 78 | MP0001800_abnormal_humoral_immune | 0.85758630 |
| 79 | MP0001853_heart_inflammation | 0.85269178 |
| 80 | MP0009333_abnormal_splenocyte_physiolog | 0.83417735 |
| 81 | MP0001919_abnormal_reproductive_system | 0.83074096 |
| 82 | MP0006082_CNS_inflammation | 0.83038861 |
| 83 | MP0002210_abnormal_sex_determination | 0.82110799 |
| 84 | MP0001145_abnormal_male_reproductive | 0.81567087 |
| 85 | MP0005448_abnormal_energy_balance | 0.78629598 |
| 86 | MP0003011_delayed_dark_adaptation | 0.78283172 |
| 87 | MP0008932_abnormal_embryonic_tissue | 0.76595716 |
| 88 | MP0003943_abnormal_hepatobiliary_system | 0.75640450 |
| 89 | MP0001756_abnormal_urination | 0.75637071 |
| 90 | MP0000653_abnormal_sex_gland | 0.74705846 |
| 91 | MP0001986_abnormal_taste_sensitivity | 0.74446596 |
| 92 | MP0001790_abnormal_immune_system | 0.74340801 |
| 93 | MP0005387_immune_system_phenotype | 0.74340801 |
| 94 | MP0000631_abnormal_neuroendocrine_gland | 0.72692196 |
| 95 | MP0002693_abnormal_pancreas_physiology | 0.72021743 |
| 96 | MP0005319_abnormal_enzyme/_coenzyme | 0.68844539 |
| 97 | MP0003077_abnormal_cell_cycle | 0.67291389 |
| 98 | MP0002163_abnormal_gland_morphology | 0.66102685 |
| 99 | MP0000689_abnormal_spleen_morphology | 0.63838262 |
| 100 | MP0003763_abnormal_thymus_physiology | 0.62290357 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Increased hepatocellular lipid droplets (HP:0006565) | 4.08060197 |
| 2 | Congenital, generalized hypertrichosis (HP:0004540) | 3.87646928 |
| 3 | Lipid accumulation in hepatocytes (HP:0006561) | 3.69572115 |
| 4 | Methylmalonic acidemia (HP:0002912) | 3.52237583 |
| 5 | Increased CSF lactate (HP:0002490) | 3.41602722 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.35132403 |
| 7 | Acute necrotizing encephalopathy (HP:0006965) | 3.33269247 |
| 8 | 3-Methylglutaconic aciduria (HP:0003535) | 3.22375745 |
| 9 | Hepatocellular necrosis (HP:0001404) | 3.16559381 |
| 10 | Abnormality of alanine metabolism (HP:0010916) | 3.03000880 |
| 11 | Hyperalaninemia (HP:0003348) | 3.03000880 |
| 12 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.03000880 |
| 13 | Genetic anticipation (HP:0003743) | 3.02729919 |
| 14 | Progressive macrocephaly (HP:0004481) | 3.02274290 |
| 15 | Acute encephalopathy (HP:0006846) | 2.94250292 |
| 16 | Abnormality of methionine metabolism (HP:0010901) | 2.93271346 |
| 17 | Abnormality of the pons (HP:0007361) | 2.93172225 |
| 18 | Methylmalonic aciduria (HP:0012120) | 2.86226840 |
| 19 | Exertional dyspnea (HP:0002875) | 2.85883680 |
| 20 | Type I transferrin isoform profile (HP:0003642) | 2.85080613 |
| 21 | Abnormality of homocysteine metabolism (HP:0010919) | 2.84250111 |
| 22 | Homocystinuria (HP:0002156) | 2.84250111 |
| 23 | Constricted visual fields (HP:0001133) | 2.79726584 |
| 24 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.77269438 |
| 25 | Hepatic necrosis (HP:0002605) | 2.75778774 |
| 26 | Hypoplasia of the pons (HP:0012110) | 2.74334555 |
| 27 | Renal Fanconi syndrome (HP:0001994) | 2.67570449 |
| 28 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.62436861 |
| 29 | Increased serum lactate (HP:0002151) | 2.56349538 |
| 30 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.56254214 |
| 31 | Increased intramyocellular lipid droplets (HP:0012240) | 2.55122252 |
| 32 | Abnormal protein glycosylation (HP:0012346) | 2.48299747 |
| 33 | Abnormal glycosylation (HP:0012345) | 2.48299747 |
| 34 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.48299747 |
| 35 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.48299747 |
| 36 | Hypothermia (HP:0002045) | 2.46992719 |
| 37 | Lactic acidosis (HP:0003128) | 2.46127148 |
| 38 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.45963081 |
| 39 | Optic disc pallor (HP:0000543) | 2.43522288 |
| 40 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.41103787 |
| 41 | Cerebral edema (HP:0002181) | 2.40339001 |
| 42 | Attenuation of retinal blood vessels (HP:0007843) | 2.40175546 |
| 43 | Cerebral hypomyelination (HP:0006808) | 2.37780065 |
| 44 | Abnormality of vitamin B metabolism (HP:0004340) | 2.37490984 |
| 45 | IgG deficiency (HP:0004315) | 2.34816447 |
| 46 | Abolished electroretinogram (ERG) (HP:0000550) | 2.34088784 |
| 47 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.32837896 |
| 48 | Thyroiditis (HP:0100646) | 2.28759087 |
| 49 | Severe combined immunodeficiency (HP:0004430) | 2.27643995 |
| 50 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.27222052 |
| 51 | Abnormality of midbrain morphology (HP:0002418) | 2.24795162 |
| 52 | Molar tooth sign on MRI (HP:0002419) | 2.24795162 |
| 53 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.23911152 |
| 54 | Hypoproteinemia (HP:0003075) | 2.22786188 |
| 55 | Palpitations (HP:0001962) | 2.22570041 |
| 56 | Abnormal albumin level (HP:0012116) | 2.19998617 |
| 57 | Hypoalbuminemia (HP:0003073) | 2.19998617 |
| 58 | Microvesicular hepatic steatosis (HP:0001414) | 2.17105213 |
| 59 | Abnormality of serum amino acid levels (HP:0003112) | 2.15938355 |
| 60 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.15295889 |
| 61 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.15295889 |
| 62 | Pancreatic cysts (HP:0001737) | 2.11405245 |
| 63 | Conjunctival hamartoma (HP:0100780) | 2.11228286 |
| 64 | Medial flaring of the eyebrow (HP:0010747) | 2.06748997 |
| 65 | Stenosis of the external auditory canal (HP:0000402) | 2.06312638 |
| 66 | Lethargy (HP:0001254) | 2.05952702 |
| 67 | Meckel diverticulum (HP:0002245) | 2.05086988 |
| 68 | Abnormality of the preputium (HP:0100587) | 2.04243035 |
| 69 | Abnormality of the ileum (HP:0001549) | 2.04008014 |
| 70 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.02368225 |
| 71 | Progressive microcephaly (HP:0000253) | 2.00584000 |
| 72 | Increased muscle lipid content (HP:0009058) | 2.00061436 |
| 73 | Insulin-resistant diabetes mellitus (HP:0000831) | 1.97084540 |
| 74 | Respiratory difficulties (HP:0002880) | 1.96321024 |
| 75 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.95562232 |
| 76 | Progressive cerebellar ataxia (HP:0002073) | 1.95143673 |
| 77 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.94293168 |
| 78 | Abnormality of chromosome stability (HP:0003220) | 1.93841542 |
| 79 | Aplastic anemia (HP:0001915) | 1.93187723 |
| 80 | Hyperglycemia (HP:0003074) | 1.91545895 |
| 81 | CNS demyelination (HP:0007305) | 1.90660073 |
| 82 | Hypoplasia of the fovea (HP:0007750) | 1.89880691 |
| 83 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.89880691 |
| 84 | Abnormality of eosinophils (HP:0001879) | 1.87884332 |
| 85 | Panhypogammaglobulinemia (HP:0003139) | 1.87153963 |
| 86 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.86716702 |
| 87 | Pancreatic fibrosis (HP:0100732) | 1.86308728 |
| 88 | Neoplasm of the rectum (HP:0100743) | 1.84002125 |
| 89 | Hypoglycemic coma (HP:0001325) | 1.82782884 |
| 90 | Degeneration of anterior horn cells (HP:0002398) | 1.81791175 |
| 91 | Abnormality of the anterior horn cell (HP:0006802) | 1.81791175 |
| 92 | Hypoglycemic seizures (HP:0002173) | 1.80087437 |
| 93 | Metaphyseal dysplasia (HP:0100255) | 1.79056803 |
| 94 | Glycosuria (HP:0003076) | 1.78552431 |
| 95 | Abnormality of urine glucose concentration (HP:0011016) | 1.78552431 |
| 96 | Combined immunodeficiency (HP:0005387) | 1.78310940 |
| 97 | Congenital stationary night blindness (HP:0007642) | 1.75370904 |
| 98 | Neuroendocrine neoplasm (HP:0100634) | 1.75367455 |
| 99 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.69290266 |
| 100 | Gaze-evoked nystagmus (HP:0000640) | 1.68894703 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TIE1 | 4.61437757 |
| 2 | EIF2AK3 | 3.05398442 |
| 3 | TRIM28 | 2.99313551 |
| 4 | EIF2AK1 | 2.83285096 |
| 5 | NUAK1 | 2.80509331 |
| 6 | TLK1 | 2.53771222 |
| 7 | MAP3K12 | 2.48589658 |
| 8 | TSSK6 | 2.48098112 |
| 9 | TRPM7 | 2.36258508 |
| 10 | INSRR | 2.34295399 |
| 11 | GRK1 | 2.26102022 |
| 12 | MST4 | 2.20994142 |
| 13 | BCKDK | 2.09262519 |
| 14 | BUB1 | 2.05542582 |
| 15 | SRPK1 | 2.05084264 |
| 16 | ZAK | 1.83198472 |
| 17 | ACVR1B | 1.79084846 |
| 18 | FRK | 1.79024999 |
| 19 | TXK | 1.64327933 |
| 20 | MAP4K2 | 1.63512621 |
| 21 | CDK19 | 1.56631016 |
| 22 | NME1 | 1.52136017 |
| 23 | OXSR1 | 1.51179102 |
| 24 | PBK | 1.47228648 |
| 25 | NEK1 | 1.44629970 |
| 26 | BMPR1B | 1.44091276 |
| 27 | KIT | 1.41682876 |
| 28 | STK16 | 1.41529003 |
| 29 | TEC | 1.37113510 |
| 30 | BCR | 1.31478037 |
| 31 | PLK3 | 1.31018136 |
| 32 | MKNK2 | 1.29115801 |
| 33 | MKNK1 | 1.28125362 |
| 34 | FLT3 | 1.23170656 |
| 35 | CDK8 | 1.21064657 |
| 36 | FER | 1.20877454 |
| 37 | CSNK1G1 | 1.20045939 |
| 38 | CSNK1G3 | 1.19975201 |
| 39 | WNK3 | 1.17686034 |
| 40 | PLK4 | 1.16867652 |
| 41 | TAOK3 | 1.15780510 |
| 42 | MYLK | 1.15058695 |
| 43 | ILK | 1.14682249 |
| 44 | VRK2 | 1.11380936 |
| 45 | MAPKAPK5 | 1.08903605 |
| 46 | ADRBK2 | 1.08059570 |
| 47 | DAPK1 | 1.07505797 |
| 48 | WNK4 | 0.99484323 |
| 49 | CSNK1G2 | 0.97163903 |
| 50 | CSNK1A1L | 0.94702558 |
| 51 | PHKG2 | 0.93727299 |
| 52 | PHKG1 | 0.93727299 |
| 53 | ERBB3 | 0.93113910 |
| 54 | VRK1 | 0.92878579 |
| 55 | TGFBR1 | 0.87718117 |
| 56 | MAPKAPK3 | 0.86486870 |
| 57 | TTK | 0.86451133 |
| 58 | SIK3 | 0.82503075 |
| 59 | PINK1 | 0.79146052 |
| 60 | BMPR2 | 0.79049100 |
| 61 | MAP2K6 | 0.76470566 |
| 62 | EIF2AK2 | 0.74283671 |
| 63 | PLK2 | 0.71788577 |
| 64 | IRAK1 | 0.71004381 |
| 65 | PDK2 | 0.70373747 |
| 66 | MATK | 0.70005047 |
| 67 | EPHA3 | 0.69494383 |
| 68 | DYRK2 | 0.66533827 |
| 69 | ALK | 0.64331158 |
| 70 | CAMKK2 | 0.60455969 |
| 71 | FES | 0.56943405 |
| 72 | TNIK | 0.56265245 |
| 73 | BRSK2 | 0.55275357 |
| 74 | RPS6KA5 | 0.53693935 |
| 75 | PLK1 | 0.52275382 |
| 76 | GRK5 | 0.47669821 |
| 77 | PASK | 0.43975056 |
| 78 | IKBKB | 0.43125398 |
| 79 | NLK | 0.40061546 |
| 80 | CCNB1 | 0.36252961 |
| 81 | ADRBK1 | 0.36069742 |
| 82 | CSNK1A1 | 0.35616226 |
| 83 | OBSCN | 0.34380032 |
| 84 | CSNK2A1 | 0.33676560 |
| 85 | LCK | 0.33323908 |
| 86 | MINK1 | 0.32237808 |
| 87 | ITK | 0.31163585 |
| 88 | IGF1R | 0.30253573 |
| 89 | PRKCG | 0.28209580 |
| 90 | CAMK2A | 0.27723047 |
| 91 | GRK7 | 0.27581580 |
| 92 | CSNK2A2 | 0.26818085 |
| 93 | ATM | 0.26669053 |
| 94 | MAP4K1 | 0.25349879 |
| 95 | EGFR | 0.25282224 |
| 96 | CSNK1D | 0.24498281 |
| 97 | PRKCE | 0.24091549 |
| 98 | AURKB | 0.23985548 |
| 99 | DAPK2 | 0.22078014 |
| 100 | PRKCA | 0.19185582 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.67782328 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.41237260 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.96364707 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.87657863 |
| 5 | Asthma_Homo sapiens_hsa05310 | 2.68937052 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 2.60679663 |
| 7 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.54584381 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.33273044 |
| 9 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.17527167 |
| 10 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.17454354 |
| 11 | Allograft rejection_Homo sapiens_hsa05330 | 2.07567871 |
| 12 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.97677147 |
| 13 | Basal transcription factors_Homo sapiens_hsa03022 | 1.91385309 |
| 14 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.86704386 |
| 15 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.81809345 |
| 16 | RNA transport_Homo sapiens_hsa03013 | 1.73019678 |
| 17 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.72389146 |
| 18 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.72368461 |
| 19 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.70030125 |
| 20 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.65916632 |
| 21 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.64697972 |
| 22 | Mismatch repair_Homo sapiens_hsa03430 | 1.63452640 |
| 23 | Homologous recombination_Homo sapiens_hsa03440 | 1.62911449 |
| 24 | RNA degradation_Homo sapiens_hsa03018 | 1.59870663 |
| 25 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.59380536 |
| 26 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.51090444 |
| 27 | Phototransduction_Homo sapiens_hsa04744 | 1.46669396 |
| 28 | Spliceosome_Homo sapiens_hsa03040 | 1.45505600 |
| 29 | Alzheimers disease_Homo sapiens_hsa05010 | 1.40948458 |
| 30 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.39738230 |
| 31 | Ribosome_Homo sapiens_hsa03010 | 1.36164535 |
| 32 | Huntingtons disease_Homo sapiens_hsa05016 | 1.31127230 |
| 33 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.29369267 |
| 34 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.26290500 |
| 35 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.19152200 |
| 36 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.18527080 |
| 37 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.17406805 |
| 38 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.14824357 |
| 39 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.11433781 |
| 40 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.11231445 |
| 41 | DNA replication_Homo sapiens_hsa03030 | 1.10237726 |
| 42 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.08918017 |
| 43 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.08138234 |
| 44 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.02220449 |
| 45 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.01986765 |
| 46 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.01630013 |
| 47 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.00703566 |
| 48 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.99962379 |
| 49 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.96117863 |
| 50 | Purine metabolism_Homo sapiens_hsa00230 | 0.95315662 |
| 51 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.95170911 |
| 52 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.87167343 |
| 53 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.86534619 |
| 54 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.84424051 |
| 55 | Legionellosis_Homo sapiens_hsa05134 | 0.80546045 |
| 56 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.74287893 |
| 57 | Mineral absorption_Homo sapiens_hsa04978 | 0.68439452 |
| 58 | Base excision repair_Homo sapiens_hsa03410 | 0.67895778 |
| 59 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.67319951 |
| 60 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.66903197 |
| 61 | Peroxisome_Homo sapiens_hsa04146 | 0.65096954 |
| 62 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.64811708 |
| 63 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.64684366 |
| 64 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.63779323 |
| 65 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.62050363 |
| 66 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.59511487 |
| 67 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.59442894 |
| 68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.59356281 |
| 69 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.59037848 |
| 70 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.58311243 |
| 71 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.57014115 |
| 72 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.54426159 |
| 73 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.54319803 |
| 74 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.53644060 |
| 75 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.53552221 |
| 76 | Viral myocarditis_Homo sapiens_hsa05416 | 0.49566162 |
| 77 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.48727584 |
| 78 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.47829053 |
| 79 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.46833635 |
| 80 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.45756987 |
| 81 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.40496711 |
| 82 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.39819078 |
| 83 | Leishmaniasis_Homo sapiens_hsa05140 | 0.39157968 |
| 84 | Malaria_Homo sapiens_hsa05144 | 0.38962491 |
| 85 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.38139213 |
| 86 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.38049512 |
| 87 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.37425505 |
| 88 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.36048362 |
| 89 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.35338727 |
| 90 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.34664776 |
| 91 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.34255003 |
| 92 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.32515423 |
| 93 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.30361682 |
| 94 | Carbon metabolism_Homo sapiens_hsa01200 | 0.30329953 |
| 95 | Olfactory transduction_Homo sapiens_hsa04740 | 0.28454292 |
| 96 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.27959733 |
| 97 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.26971383 |
| 98 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.26020052 |
| 99 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.24462663 |
| 100 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.22559879 |

