PDCL3P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.00243222
2phenylpropanoid metabolic process (GO:0009698)5.51777043
3inositol phosphate dephosphorylation (GO:0046855)5.14954897
4phosphorylated carbohydrate dephosphorylation (GO:0046838)5.14954897
5inositol phosphate catabolic process (GO:0071545)4.88489812
6parturition (GO:0007567)4.70009284
7locomotory exploration behavior (GO:0035641)4.69023569
8positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.28700872
9piRNA metabolic process (GO:0034587)4.22667734
10respiratory chain complex IV assembly (GO:0008535)4.13604789
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02285011
12DNA deamination (GO:0045006)3.96368825
13protein complex biogenesis (GO:0070271)3.92923402
14positive regulation of digestive system process (GO:0060456)3.88490023
15proteasome assembly (GO:0043248)3.88077467
16regulation of gonadotropin secretion (GO:0032276)3.79375037
17S-adenosylmethionine metabolic process (GO:0046500)3.70077164
18cytochrome complex assembly (GO:0017004)3.65834958
19mitochondrial respiratory chain complex assembly (GO:0033108)3.63584123
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.61780663
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.61780663
22NADH dehydrogenase complex assembly (GO:0010257)3.61780663
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.60417601
24negative regulation of norepinephrine secretion (GO:0010700)3.52274152
25polyol catabolic process (GO:0046174)3.51279769
26synaptic transmission, dopaminergic (GO:0001963)3.51271516
27ether metabolic process (GO:0018904)3.51151902
28cullin deneddylation (GO:0010388)3.47382674
29cell wall macromolecule catabolic process (GO:0016998)3.38528155
30glucocorticoid biosynthetic process (GO:0006704)3.35892936
31protein deneddylation (GO:0000338)3.29325495
32ATP synthesis coupled proton transport (GO:0015986)3.28317099
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28317099
34positive regulation of calcium ion import (GO:0090280)3.21280967
35negative regulation of catecholamine secretion (GO:0033604)3.21241940
36energy homeostasis (GO:0097009)3.17979448
37regulation of glucocorticoid secretion (GO:2000849)3.17885386
38positive regulation of steroid hormone secretion (GO:2000833)3.15659542
39DNA methylation involved in gamete generation (GO:0043046)3.15532834
40positive regulation of circadian rhythm (GO:0042753)3.14580942
41histone H2A ubiquitination (GO:0033522)3.11633198
42inner mitochondrial membrane organization (GO:0007007)3.07634484
43negative regulation of membrane potential (GO:0045837)3.02180112
44regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.01203287
45regulation of circadian sleep/wake cycle (GO:0042749)3.01203287
46cellular ketone body metabolic process (GO:0046950)2.99636929
47negative regulation of neurological system process (GO:0031645)2.99462440
48ketone body metabolic process (GO:1902224)2.96761397
49electron transport chain (GO:0022900)2.95258131
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.93892498
51respiratory electron transport chain (GO:0022904)2.93396201
52negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.91400835
53transcription from mitochondrial promoter (GO:0006390)2.91085351
54histone H2A monoubiquitination (GO:0035518)2.91006520
55positive regulation of mitochondrial fission (GO:0090141)2.89931606
56base-excision repair, AP site formation (GO:0006285)2.89298248
57hypothalamus development (GO:0021854)2.88132369
58chaperone-mediated protein transport (GO:0072321)2.82444118
59protein polyglutamylation (GO:0018095)2.82411322
60rRNA modification (GO:0000154)2.82149839
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.80998841
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.80998841
63positive regulation of insulin secretion (GO:0032024)2.79602186
64platelet dense granule organization (GO:0060155)2.78911847
65maturation of 5.8S rRNA (GO:0000460)2.78207215
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.78026822
67xenobiotic catabolic process (GO:0042178)2.76800372
68water-soluble vitamin biosynthetic process (GO:0042364)2.76773621
69organic cation transport (GO:0015695)2.76768987
70peptidyl-histidine modification (GO:0018202)2.75295788
71mannosylation (GO:0097502)2.74127447
72negative regulation of circadian rhythm (GO:0042754)2.73372016
73male meiosis (GO:0007140)2.73176033
74regulation of hexokinase activity (GO:1903299)2.71737461
75regulation of glucokinase activity (GO:0033131)2.71737461
76cell wall macromolecule metabolic process (GO:0044036)2.71600201
77transcription elongation from RNA polymerase III promoter (GO:0006385)2.71092039
78termination of RNA polymerase III transcription (GO:0006386)2.71092039
79epithelial cilium movement (GO:0003351)2.69243909
80hydrogen ion transmembrane transport (GO:1902600)2.68611858
81ATP hydrolysis coupled proton transport (GO:0015991)2.67359637
82energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.67359637
83proton transport (GO:0015992)2.66805899
84mitochondrial RNA metabolic process (GO:0000959)2.65276597
85kidney morphogenesis (GO:0060993)2.64047511
86hydrogen transport (GO:0006818)2.63023138
87keratinocyte development (GO:0003334)2.61919577
88regulation of type B pancreatic cell apoptotic process (GO:2000674)2.61065429
89aggressive behavior (GO:0002118)2.60909000
90regulation of cilium movement (GO:0003352)2.60485957
91nephron tubule morphogenesis (GO:0072078)2.58225144
92nephron epithelium morphogenesis (GO:0072088)2.58225144
93signal peptide processing (GO:0006465)2.56733281
94detection of light stimulus involved in sensory perception (GO:0050962)2.56595179
95detection of light stimulus involved in visual perception (GO:0050908)2.56595179
96branched-chain amino acid catabolic process (GO:0009083)2.54344583
97cellular response to dexamethasone stimulus (GO:0071549)2.50802037
98axoneme assembly (GO:0035082)2.47178801
99insulin secretion (GO:0030073)2.46187345
100circadian sleep/wake cycle process (GO:0022410)2.42163180

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.77000187
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.03502463
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.96695357
4ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91021414
5ZNF274_21170338_ChIP-Seq_K562_Hela2.78523903
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.68537457
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.53996946
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45313097
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.38725955
10VDR_22108803_ChIP-Seq_LS180_Human2.23997686
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.19418943
12IGF1R_20145208_ChIP-Seq_DFB_Human2.07573293
13VDR_23849224_ChIP-Seq_CD4+_Human2.05133514
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99673804
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98827471
16SRF_21415370_ChIP-Seq_HL-1_Mouse1.93600656
17FUS_26573619_Chip-Seq_HEK293_Human1.92244735
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80351025
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.77260006
20FOXA1_27270436_Chip-Seq_PROSTATE_Human1.75786176
21FOXA1_25329375_ChIP-Seq_VCAP_Human1.75786176
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72729202
23EWS_26573619_Chip-Seq_HEK293_Human1.72708664
24TP53_22573176_ChIP-Seq_HFKS_Human1.70360630
25P300_19829295_ChIP-Seq_ESCs_Human1.63864628
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62296409
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61670199
28GBX2_23144817_ChIP-Seq_PC3_Human1.61535542
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.59038764
30FOXP3_21729870_ChIP-Seq_TREG_Human1.57113943
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52880033
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52155701
33ER_23166858_ChIP-Seq_MCF-7_Human1.47288927
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44086571
35CBP_20019798_ChIP-Seq_JUKART_Human1.44086571
36TAF15_26573619_Chip-Seq_HEK293_Human1.43268862
37AR_20517297_ChIP-Seq_VCAP_Human1.43150472
38ELK1_19687146_ChIP-ChIP_HELA_Human1.42069329
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.41091774
40HTT_18923047_ChIP-ChIP_STHdh_Human1.40122383
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40073591
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38051506
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37517454
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34683149
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34372994
46NANOG_19829295_ChIP-Seq_ESCs_Human1.31978690
47SOX2_19829295_ChIP-Seq_ESCs_Human1.31978690
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31205299
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31181944
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30563657
51SALL4_22934838_ChIP-ChIP_CD34+_Human1.28737940
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26433528
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.26226403
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.26164088
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.25133385
56STAT3_18555785_Chip-Seq_ESCs_Mouse1.24408609
57FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24242012
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21835009
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.18913141
60P53_22387025_ChIP-Seq_ESCs_Mouse1.16458489
61CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15872887
62NCOR_22424771_ChIP-Seq_293T_Human1.14966784
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14805063
64AR_25329375_ChIP-Seq_VCAP_Human1.14690822
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.14213685
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.13889955
67CDX2_22108803_ChIP-Seq_LS180_Human1.13607922
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13468650
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12427853
70ERG_20517297_ChIP-Seq_VCAP_Human1.11374584
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10572373
72PHF8_20622853_ChIP-Seq_HELA_Human1.10051586
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09299343
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08889300
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08255973
76GATA3_26560356_Chip-Seq_TH2_Human1.07633237
77BCAT_22108803_ChIP-Seq_LS180_Human1.06786768
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06417397
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05846456
80GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05247241
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.05168596
82RBPJ_21746931_ChIP-Seq_IB4_Human1.05132755
83TCF4_23295773_ChIP-Seq_U87_Human1.05125971
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04770514
85ETV1_20927104_ChIP-Seq_GIST48_Human1.03218082
86GATA6_21074721_ChIP-Seq_CACO-2_Human1.02354335
87PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02029235
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01738036
89OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01244250
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01159908
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01145764
92IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00567062
93TCF4_22108803_ChIP-Seq_LS180_Human1.00397278
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99802733
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99310999
96MYC_18940864_ChIP-ChIP_HL60_Human0.98527980
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98394152
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97328896
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96944511
100REST_21632747_ChIP-Seq_MESCs_Mouse0.96854810

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation3.86083910
2MP0002837_dystrophic_cardiac_calcinosis3.48764321
3MP0003787_abnormal_imprinting3.14376596
4MP0003718_maternal_effect2.88814118
5MP0006292_abnormal_olfactory_placode2.75345335
6MP0004147_increased_porphyrin_level2.67196118
7MP0005075_abnormal_melanosome_morpholog2.61516962
8MP0001986_abnormal_taste_sensitivity2.53062584
9MP0003880_abnormal_central_pattern2.37396869
10MP0008877_abnormal_DNA_methylation2.35245888
11MP0005551_abnormal_eye_electrophysiolog2.23093224
12MP0002102_abnormal_ear_morphology2.15352016
13MP0002653_abnormal_ependyma_morphology2.14881333
14MP0006036_abnormal_mitochondrial_physio2.12590655
15MP0002822_catalepsy1.99455855
16MP0000569_abnormal_digit_pigmentation1.93544368
17MP0005646_abnormal_pituitary_gland1.87178948
18MP0006072_abnormal_retinal_apoptosis1.85965023
19MP0000013_abnormal_adipose_tissue1.83830206
20MP0004782_abnormal_surfactant_physiolog1.75194220
21MP0008872_abnormal_physiological_respon1.73984532
22MP0003195_calcinosis1.70788726
23MP0001968_abnormal_touch/_nociception1.54772237
24MP0005389_reproductive_system_phenotype1.54094374
25MP0002736_abnormal_nociception_after1.53451284
26MP0002693_abnormal_pancreas_physiology1.53354885
27MP0002163_abnormal_gland_morphology1.50462476
28MP0002160_abnormal_reproductive_system1.50116962
29MP0004885_abnormal_endolymph1.43812044
30MP0002909_abnormal_adrenal_gland1.43622390
31MP0005253_abnormal_eye_physiology1.40480805
32MP0005379_endocrine/exocrine_gland_phen1.38255152
33MP0003656_abnormal_erythrocyte_physiolo1.37084211
34MP0001905_abnormal_dopamine_level1.35605080
35MP0001756_abnormal_urination1.35393320
36MP0005636_abnormal_mineral_homeostasis1.35180167
37MP0001944_abnormal_pancreas_morphology1.35056128
38MP0005645_abnormal_hypothalamus_physiol1.35021831
39MP0000015_abnormal_ear_pigmentation1.34727071
40MP0006082_CNS_inflammation1.34042238
41MP0006276_abnormal_autonomic_nervous1.30796168
42MP0002229_neurodegeneration1.28821291
43MP0002876_abnormal_thyroid_physiology1.23084454
44MP0008775_abnormal_heart_ventricle1.22748575
45MP0001501_abnormal_sleep_pattern1.21059114
46MP0005332_abnormal_amino_acid1.20941530
47MP0005174_abnormal_tail_pigmentation1.16955928
48MP0008058_abnormal_DNA_repair1.16460969
49MP0001919_abnormal_reproductive_system1.14014308
50MP0003724_increased_susceptibility_to1.13762434
51MP0008875_abnormal_xenobiotic_pharmacok1.13484126
52MP0002272_abnormal_nervous_system1.12692429
53MP0001764_abnormal_homeostasis1.11878268
54MP0005084_abnormal_gallbladder_morpholo1.10227193
55MP0004019_abnormal_vitamin_homeostasis1.09907128
56MP0001529_abnormal_vocalization1.09298959
57MP0005423_abnormal_somatic_nervous1.07995784
58MP0000639_abnormal_adrenal_gland1.07240064
59MP0003186_abnormal_redox_activity1.07084475
60MP0003806_abnormal_nucleotide_metabolis1.06101951
61MP0002009_preneoplasia1.04845670
62MP0009046_muscle_twitch1.02178852
63MP0003646_muscle_fatigue0.98397655
64MP0006035_abnormal_mitochondrial_morpho0.97611968
65MP0004145_abnormal_muscle_electrophysio0.96713396
66MP0001661_extended_life_span0.96537768
67MP0001348_abnormal_lacrimal_gland0.96480266
68MP0005410_abnormal_fertilization0.94591170
69MP0002138_abnormal_hepatobiliary_system0.92994945
70MP0002090_abnormal_vision0.90751909
71MP0002095_abnormal_skin_pigmentation0.89957726
72MP0009745_abnormal_behavioral_response0.89565294
73MP0003121_genomic_imprinting0.89311641
74MP0004142_abnormal_muscle_tone0.88496706
75MP0001970_abnormal_pain_threshold0.87318765
76MP0001984_abnormal_olfaction0.85615635
77MP0001873_stomach_inflammation0.83229865
78MP0004133_heterotaxia0.83015617
79MP0005395_other_phenotype0.82315100
80MP0002166_altered_tumor_susceptibility0.81167671
81MP0010386_abnormal_urinary_bladder0.80510962
82MP0003890_abnormal_embryonic-extraembry0.79544028
83MP0001835_abnormal_antigen_presentation0.79020491
84MP0001765_abnormal_ion_homeostasis0.78893589
85MP0005319_abnormal_enzyme/_coenzyme0.77490868
86MP0003283_abnormal_digestive_organ0.76297264
87MP0005535_abnormal_body_temperature0.75674834
88MP0002064_seizures0.75638803
89MP0002928_abnormal_bile_duct0.75471865
90MP0002078_abnormal_glucose_homeostasis0.74588689
91MP0004924_abnormal_behavior0.74104130
92MP0005386_behavior/neurological_phenoty0.74104130
93MP0009780_abnormal_chondrocyte_physiolo0.73175015
94MP0002184_abnormal_innervation0.72090493
95MP0005367_renal/urinary_system_phenotyp0.71739371
96MP0000516_abnormal_urinary_system0.71739371
97MP0001929_abnormal_gametogenesis0.71675730
98MP0001324_abnormal_eye_pigmentation0.70626858
99MP0002733_abnormal_thermal_nociception0.70290514
100MP0000631_abnormal_neuroendocrine_gland0.69453308

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)3.63045560
2Hepatic necrosis (HP:0002605)3.53406371
3Polydipsia (HP:0001959)3.44234285
4Abnormal drinking behavior (HP:0030082)3.44234285
5Hypothermia (HP:0002045)3.41728666
6Hepatocellular necrosis (HP:0001404)3.34906716
7Progressive macrocephaly (HP:0004481)3.34597660
8Acute necrotizing encephalopathy (HP:0006965)3.29927065
9Hyperglycemia (HP:0003074)3.29021121
10Mitochondrial inheritance (HP:0001427)3.22473479
11Increased CSF lactate (HP:0002490)3.18292802
12Pancreatic cysts (HP:0001737)3.14758588
13Pancreatic fibrosis (HP:0100732)3.10811987
14Hypoglycemic coma (HP:0001325)3.04975803
15Insulin-resistant diabetes mellitus (HP:0000831)3.03943120
16Abnormality of the renal cortex (HP:0011035)3.00103504
17Decreased electroretinogram (ERG) amplitude (HP:0000654)2.97839852
18Nephronophthisis (HP:0000090)2.96579287
19Abnormality of midbrain morphology (HP:0002418)2.83669559
20Molar tooth sign on MRI (HP:0002419)2.83669559
21Abnormal mitochondria in muscle tissue (HP:0008316)2.79236706
22Acute encephalopathy (HP:0006846)2.76453163
23Polyuria (HP:0000103)2.74899427
24Medial flaring of the eyebrow (HP:0010747)2.74633817
25Hypoglycemic seizures (HP:0002173)2.72738632
26Abolished electroretinogram (ERG) (HP:0000550)2.70399643
27Renal Fanconi syndrome (HP:0001994)2.64623531
28Tubular atrophy (HP:0000092)2.63296240
29Ketoacidosis (HP:0001993)2.61191787
30Hypoproteinemia (HP:0003075)2.60866195
31True hermaphroditism (HP:0010459)2.58864970
32Abnormality of the renal medulla (HP:0100957)2.57695279
33Abnormal hair whorl (HP:0010721)2.50541986
34Congenital stationary night blindness (HP:0007642)2.50156853
35Testicular atrophy (HP:0000029)2.49218721
36Generalized aminoaciduria (HP:0002909)2.49004868
373-Methylglutaconic aciduria (HP:0003535)2.48492777
38Glycosuria (HP:0003076)2.46875276
39Abnormality of urine glucose concentration (HP:0011016)2.46875276
40Attenuation of retinal blood vessels (HP:0007843)2.36244786
41Hemiparesis (HP:0001269)2.35236871
42Abnormal biliary tract physiology (HP:0012439)2.35000815
43Bile duct proliferation (HP:0001408)2.35000815
44Renal cortical cysts (HP:0000803)2.33906061
45Hypomagnesemia (HP:0002917)2.25605488
46Cystic liver disease (HP:0006706)2.24045007
47Increased hepatocellular lipid droplets (HP:0006565)2.21725398
48Optic disc pallor (HP:0000543)2.20849201
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18027143
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18027143
51Abnormal urine output (HP:0012590)2.17299389
52Bony spicule pigmentary retinopathy (HP:0007737)2.15973002
53Panhypogammaglobulinemia (HP:0003139)2.15943690
54Rib fusion (HP:0000902)2.12956858
55Abnormal rod and cone electroretinograms (HP:0008323)2.11620941
56Hyperlipoproteinemia (HP:0010980)2.10524146
57Cerebral edema (HP:0002181)2.09384475
58Hypoplasia of the fovea (HP:0007750)2.04444536
59Aplasia/Hypoplasia of the fovea (HP:0008060)2.04444536
60Myokymia (HP:0002411)2.04010665
61Ketosis (HP:0001946)2.03916529
62Amyotrophic lateral sclerosis (HP:0007354)2.03834205
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03425101
64Rectal fistula (HP:0100590)2.00670891
65Rectovaginal fistula (HP:0000143)2.00670891
66Lactic acidosis (HP:0003128)1.99814079
67Large for gestational age (HP:0001520)1.98371429
68Abnormality of renal excretion (HP:0011036)1.97323682
69CNS demyelination (HP:0007305)1.97309406
70Methylmalonic acidemia (HP:0002912)1.97071142
71Increased serum lactate (HP:0002151)1.95955566
72Symptomatic seizures (HP:0011145)1.93388498
73Nephrogenic diabetes insipidus (HP:0009806)1.93001626
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92487547
75Adrenal hypoplasia (HP:0000835)1.91872163
76Abnormality of endocrine pancreas physiology (HP:0012093)1.91429378
77Abnormality of the pancreatic islet cells (HP:0006476)1.91429378
78Abnormality of the distal phalanges of the toes (HP:0010182)1.89747471
79Poor suck (HP:0002033)1.89389547
80Myotonia (HP:0002486)1.87362257
81Congenital primary aphakia (HP:0007707)1.86169040
82Respiratory failure (HP:0002878)1.86017663
83Exertional dyspnea (HP:0002875)1.85239103
84Lipid accumulation in hepatocytes (HP:0006561)1.84644330
85Growth hormone deficiency (HP:0000824)1.83918508
86Congenital, generalized hypertrichosis (HP:0004540)1.83098928
87Hyperglycinemia (HP:0002154)1.83048870
88Methylmalonic aciduria (HP:0012120)1.82981801
89Conjunctival hamartoma (HP:0100780)1.82909882
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82822903
91Dicarboxylic aciduria (HP:0003215)1.82822903
92Palpitations (HP:0001962)1.82165941
93Bifid tongue (HP:0010297)1.82057510
94Facial diplegia (HP:0001349)1.81955093
95Constricted visual fields (HP:0001133)1.78761300
96Gait imbalance (HP:0002141)1.77062528
97Abnormality of renal resorption (HP:0011038)1.76894562
98Decreased circulating renin level (HP:0003351)1.76013204
99Abnormality of the right ventricle (HP:0001707)1.74494849
100Hyperglycinuria (HP:0003108)1.73366048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.30467779
2MAPKAPK33.50962278
3MST43.08963665
4BMPR22.73746291
5EIF2AK12.59342690
6STK162.47077820
7EIF2AK32.32918890
8PHKG22.06540391
9PHKG12.06540391
10TRPM72.03041078
11BMPR1B2.02154175
12MAP4K22.00103827
13NUAK11.94519001
14GRK11.91983571
15TIE11.90604375
16MAP3K91.86692090
17EEF2K1.76217713
18TEC1.68029384
19MAPKAPK51.63860015
20OXSR11.61039248
21CASK1.60233557
22CSNK1G31.57973501
23MAP3K131.57127232
24CSNK1G11.52753183
25ADRBK21.51831809
26TNIK1.47967342
27ERBB31.46343284
28CAMKK21.42478059
29MAPK131.40392342
30CSNK1G21.39136340
31NTRK31.36472252
32TAOK31.33674162
33RPS6KB21.33386838
34FGFR21.30255393
35RIPK41.25946480
36NLK1.16849892
37BCKDK1.12313435
38CSNK1A1L1.11646067
39WNK41.11221569
40DAPK21.09857272
41TXK1.05359342
42PLK21.02861369
43KIT0.99482595
44ACVR1B0.95309471
45ITK0.94267334
46MAP3K40.94258176
47TLK10.94256940
48MAP3K140.93696415
49MAP3K120.91794520
50CDK190.90120816
51WNK30.88150910
52IKBKB0.87378477
53PINK10.86362691
54PIK3CA0.85802422
55BTK0.83130495
56TRIM280.81349717
57SYK0.79622604
58ZAK0.78554793
59PRKCE0.77841914
60PTK2B0.74636756
61PBK0.73866651
62SIK30.72061322
63MAP4K10.70664563
64INSRR0.70376769
65STK390.69966153
66FES0.62104231
67DAPK10.61929530
68TNK20.58926275
69MAP2K60.57634495
70EIF2AK20.56696426
71PIK3CG0.56625703
72GRK50.53696472
73MAP2K70.53068073
74ILK0.52849495
75CSNK1D0.49914546
76VRK20.49135968
77OBSCN0.46103365
78MAPK110.43879042
79ADRBK10.43295470
80RPS6KB10.42549398
81LYN0.42510106
82FER0.39138716
83LCK0.38331207
84CDK80.37722193
85PRKAA20.37004652
86CSNK1A10.36736215
87CSF1R0.36540165
88BRSK20.35687781
89VRK10.34843273
90AKT20.34815987
91PLK30.34655159
92DYRK20.34577135
93STK38L0.33125946
94BCR0.32910831
95PRKG10.31593182
96PRKCQ0.31294280
97MAP2K20.30036263
98PRKACA0.29911084
99PRKAA10.29161790
100PRKCG0.28289537

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.43966086
2Protein export_Homo sapiens_hsa030603.36412370
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.06919313
4Asthma_Homo sapiens_hsa053103.01213325
5Parkinsons disease_Homo sapiens_hsa050122.80686058
6Proteasome_Homo sapiens_hsa030502.50563148
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.42638338
8Phototransduction_Homo sapiens_hsa047442.41994388
9Type I diabetes mellitus_Homo sapiens_hsa049402.41462475
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.38722117
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20879978
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.19098874
13Collecting duct acid secretion_Homo sapiens_hsa049662.14292547
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08101999
15RNA polymerase_Homo sapiens_hsa030202.05714217
16Allograft rejection_Homo sapiens_hsa053302.05486859
17Autoimmune thyroid disease_Homo sapiens_hsa053202.01837958
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95586870
19Regulation of autophagy_Homo sapiens_hsa041401.77588946
20Butanoate metabolism_Homo sapiens_hsa006501.72308566
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62590617
22Fatty acid elongation_Homo sapiens_hsa000621.57866089
23Alzheimers disease_Homo sapiens_hsa050101.53088367
24Graft-versus-host disease_Homo sapiens_hsa053321.52901600
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49946254
26Nitrogen metabolism_Homo sapiens_hsa009101.48592389
27Huntingtons disease_Homo sapiens_hsa050161.43743028
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37511546
29Rheumatoid arthritis_Homo sapiens_hsa053231.34893926
30Peroxisome_Homo sapiens_hsa041461.34221568
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31241968
32Linoleic acid metabolism_Homo sapiens_hsa005911.30690237
33Sulfur metabolism_Homo sapiens_hsa009201.30068511
34RNA degradation_Homo sapiens_hsa030181.24810258
35Tryptophan metabolism_Homo sapiens_hsa003801.22937843
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18271898
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17235276
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16303228
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13830709
40Ether lipid metabolism_Homo sapiens_hsa005651.09576507
41Selenocompound metabolism_Homo sapiens_hsa004501.06839474
42One carbon pool by folate_Homo sapiens_hsa006701.04964542
43Arachidonic acid metabolism_Homo sapiens_hsa005901.03931132
44Basal transcription factors_Homo sapiens_hsa030221.03129352
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02416107
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01955689
47Cardiac muscle contraction_Homo sapiens_hsa042600.92116490
48Insulin secretion_Homo sapiens_hsa049110.90763293
49Propanoate metabolism_Homo sapiens_hsa006400.87868820
50Folate biosynthesis_Homo sapiens_hsa007900.86180642
51Fanconi anemia pathway_Homo sapiens_hsa034600.83866970
52Circadian rhythm_Homo sapiens_hsa047100.82541978
53Antigen processing and presentation_Homo sapiens_hsa046120.80382209
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79764174
55Chemical carcinogenesis_Homo sapiens_hsa052040.74206316
56Pyruvate metabolism_Homo sapiens_hsa006200.73045291
57Olfactory transduction_Homo sapiens_hsa047400.70888175
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69887542
59Caffeine metabolism_Homo sapiens_hsa002320.68091355
60Homologous recombination_Homo sapiens_hsa034400.65873334
61Metabolic pathways_Homo sapiens_hsa011000.64058839
62Purine metabolism_Homo sapiens_hsa002300.63312504
63Non-homologous end-joining_Homo sapiens_hsa034500.60061578
64Vibrio cholerae infection_Homo sapiens_hsa051100.59429197
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58947552
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58928544
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57803069
68Pyrimidine metabolism_Homo sapiens_hsa002400.57310664
69Primary immunodeficiency_Homo sapiens_hsa053400.54375205
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51938226
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51108632
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49587679
73Retinol metabolism_Homo sapiens_hsa008300.49385678
74Fatty acid degradation_Homo sapiens_hsa000710.48188731
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46786882
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.43642429
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43184164
78Synaptic vesicle cycle_Homo sapiens_hsa047210.42954038
79RNA transport_Homo sapiens_hsa030130.42593400
80Viral myocarditis_Homo sapiens_hsa054160.42514993
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.42062704
82Ribosome_Homo sapiens_hsa030100.40003983
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39392669
84Long-term depression_Homo sapiens_hsa047300.39329662
85Fatty acid metabolism_Homo sapiens_hsa012120.38401180
86Serotonergic synapse_Homo sapiens_hsa047260.38131695
87beta-Alanine metabolism_Homo sapiens_hsa004100.37604657
88Sphingolipid metabolism_Homo sapiens_hsa006000.36570689
89Glutathione metabolism_Homo sapiens_hsa004800.36540627
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36010803
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35108658
92Taste transduction_Homo sapiens_hsa047420.33710645
93Circadian entrainment_Homo sapiens_hsa047130.33655758
94Hematopoietic cell lineage_Homo sapiens_hsa046400.30210321
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28621222
96Salivary secretion_Homo sapiens_hsa049700.27020637
97Morphine addiction_Homo sapiens_hsa050320.25603486
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24776577
99Mineral absorption_Homo sapiens_hsa049780.23596586
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.23545946

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