PDCL3P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of natural killer cell differentiation (GO:0032825)6.03612085
2replication fork processing (GO:0031297)5.31502464
3response to pheromone (GO:0019236)4.94656901
4negative regulation of smooth muscle cell differentiation (GO:0051151)4.59853452
5positive regulation of interleukin-17 production (GO:0032740)4.54186661
6DNA double-strand break processing (GO:0000729)4.49989146
7regulation of vasculogenesis (GO:2001212)4.24515137
8CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.19514943
9ventricular trabecula myocardium morphogenesis (GO:0003222)4.13828468
10cytokine production involved in immune response (GO:0002367)4.06288422
11regulation of natural killer cell differentiation (GO:0032823)3.90450791
12Notch signaling involved in heart development (GO:0061314)3.82978887
13maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.80776912
14platelet dense granule organization (GO:0060155)3.65946092
15negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.64717177
16negative regulation of T-helper cell differentiation (GO:0045623)3.64717177
17L-fucose catabolic process (GO:0042355)3.64449145
18fucose catabolic process (GO:0019317)3.64449145
19L-fucose metabolic process (GO:0042354)3.64449145
20regulation of isotype switching to IgG isotypes (GO:0048302)3.62226384
21indolalkylamine metabolic process (GO:0006586)3.61305900
22multicellular organism reproduction (GO:0032504)3.60907704
23heart trabecula morphogenesis (GO:0061384)3.52957986
24production of molecular mediator of immune response (GO:0002440)3.49294105
25positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.43892216
26regulation of MHC class II biosynthetic process (GO:0045346)3.38479167
27DNA catabolic process, exonucleolytic (GO:0000738)3.35785329
28negative regulation of nitric oxide biosynthetic process (GO:0045019)3.34714357
29GTP biosynthetic process (GO:0006183)3.33726014
30tryptophan metabolic process (GO:0006568)3.33489126
31regulation of chronic inflammatory response (GO:0002676)3.31711811
32endoderm formation (GO:0001706)3.29282843
33indole-containing compound catabolic process (GO:0042436)3.27717013
34indolalkylamine catabolic process (GO:0046218)3.27717013
35tryptophan catabolic process (GO:0006569)3.27717013
36retinal cone cell development (GO:0046549)3.17425162
37negative regulation of alpha-beta T cell differentiation (GO:0046639)3.17259169
38lymphangiogenesis (GO:0001946)3.17238083
39negative regulation of protein localization to cell surface (GO:2000009)3.14628739
40regulation of relaxation of muscle (GO:1901077)3.10240270
41regulation of endothelial cell differentiation (GO:0045601)3.08886745
42cardiac right ventricle morphogenesis (GO:0003215)3.07786985
43regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.06721442
44positive regulation of B cell proliferation (GO:0030890)3.03129091
45positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.02818963
46positive regulation of DNA recombination (GO:0045911)3.00313257
47trabecula morphogenesis (GO:0061383)2.99549008
48water-soluble vitamin biosynthetic process (GO:0042364)2.99508744
49positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.99083615
50negative regulation of acute inflammatory response (GO:0002674)2.96820655
51proteasome assembly (GO:0043248)2.95518315
52regulation of podosome assembly (GO:0071801)2.92918555
53anterograde synaptic vesicle transport (GO:0048490)2.92543515
54positive regulation of isotype switching (GO:0045830)2.90054007
55negative regulation of calcium ion transport into cytosol (GO:0010523)2.88654817
56T-helper cell differentiation (GO:0042093)2.86726070
57CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.86726070
58mitochondrial DNA replication (GO:0006264)2.86259295
59T cell lineage commitment (GO:0002360)2.85132108
60negative regulation of systemic arterial blood pressure (GO:0003085)2.82182170
61regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.81790684
62natural killer cell differentiation (GO:0001779)2.81569214
63heart valve formation (GO:0003188)2.81515764
64primary amino compound metabolic process (GO:1901160)2.79879544
65UTP biosynthetic process (GO:0006228)2.79657870
66L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.78540870
67negative regulation of transcription regulatory region DNA binding (GO:2000678)2.77073165
68protein targeting to Golgi (GO:0000042)2.76656237
69valine metabolic process (GO:0006573)2.74877889
70indole-containing compound metabolic process (GO:0042430)2.73599851
71positive regulation of organelle assembly (GO:1902117)2.73530765
72establishment of protein localization to Golgi (GO:0072600)2.69905842
73positive regulation of interleukin-10 production (GO:0032733)2.69342815
74sprouting angiogenesis (GO:0002040)2.69036592
75RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.68748709
76DNA deamination (GO:0045006)2.66428601
77endothelial tube morphogenesis (GO:0061154)2.66264010
78morphogenesis of an endothelium (GO:0003159)2.66264010
79blood vessel maturation (GO:0001955)2.64181741
80cytokine biosynthetic process (GO:0042089)2.62533079
81pyrimidine dimer repair (GO:0006290)2.61526079
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60341412
83RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60341412
84negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.60158179
85positive regulation of interleukin-1 secretion (GO:0050716)2.59143625
86negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.58109046
87C4-dicarboxylate transport (GO:0015740)2.57169525
88response to lipoprotein particle (GO:0055094)2.55098906
89cullin deneddylation (GO:0010388)2.54111515
90endothelial cell differentiation (GO:0045446)2.53267821
91positive regulation of endothelial cell differentiation (GO:0045603)2.53026136
92respiratory chain complex IV assembly (GO:0008535)2.48882419
93lung lobe morphogenesis (GO:0060463)2.46517071
94positive regulation of natural killer cell activation (GO:0032816)2.46165442
95establishment of protein localization to mitochondrial membrane (GO:0090151)2.46060574
96phosphatidylserine acyl-chain remodeling (GO:0036150)2.45733005
97UTP metabolic process (GO:0046051)2.43721852
98positive regulation of cardiac muscle cell differentiation (GO:2000727)2.42296500
99ribosome assembly (GO:0042255)2.42025436
100heart trabecula formation (GO:0060347)2.41266888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.67363670
2ZNF274_21170338_ChIP-Seq_K562_Hela3.23951481
3ZFP57_27257070_Chip-Seq_ESCs_Mouse3.20379629
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.00647431
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.86628726
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64850020
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52541545
8EWS_26573619_Chip-Seq_HEK293_Human2.43714099
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.27179299
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.23426128
11P300_19829295_ChIP-Seq_ESCs_Human2.23038723
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19203815
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13084519
14VDR_22108803_ChIP-Seq_LS180_Human2.11606031
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07061454
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.04121894
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.00817329
18ELK1_19687146_ChIP-ChIP_HELA_Human1.96250987
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.94836106
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94626405
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.91814351
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.86285819
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82317228
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79365142
25BCAT_22108803_ChIP-Seq_LS180_Human1.79170389
26TAF15_26573619_Chip-Seq_HEK293_Human1.77667136
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75404447
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75119205
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73392460
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.73116892
31IGF1R_20145208_ChIP-Seq_DFB_Human1.70336217
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68852314
33GBX2_23144817_ChIP-Seq_PC3_Human1.66996951
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65702636
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63760752
36CBP_20019798_ChIP-Seq_JUKART_Human1.60429033
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60429033
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55433778
39GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.54734169
40FUS_26573619_Chip-Seq_HEK293_Human1.54461019
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54339275
42ER_23166858_ChIP-Seq_MCF-7_Human1.50059012
43SMAD4_21799915_ChIP-Seq_A2780_Human1.47718948
44STAT3_23295773_ChIP-Seq_U87_Human1.47089741
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46973107
46TCF4_22108803_ChIP-Seq_LS180_Human1.46462832
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45314649
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43425564
49AR_25329375_ChIP-Seq_VCAP_Human1.42857404
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41708394
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41472758
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.40665671
53CDX2_22108803_ChIP-Seq_LS180_Human1.40115693
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39475285
55TP53_22573176_ChIP-Seq_HFKS_Human1.38732334
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.38427977
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.37221567
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35914974
59SOX2_19829295_ChIP-Seq_ESCs_Human1.35800751
60NANOG_19829295_ChIP-Seq_ESCs_Human1.35800751
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.35757511
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35343018
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31273242
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30719345
65TCF4_23295773_ChIP-Seq_U87_Human1.30650898
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.30339394
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29999164
68RUNX2_22187159_ChIP-Seq_PCA_Human1.22515163
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22493951
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21618070
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18850889
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18710713
73VDR_23849224_ChIP-Seq_CD4+_Human1.17981975
74TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16920814
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16866883
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16154718
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15186504
78LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11584836
79TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10982146
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.10285514
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08577339
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08166967
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07394520
84AR_20517297_ChIP-Seq_VCAP_Human1.06429053
85FOXP3_21729870_ChIP-Seq_TREG_Human1.05998523
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05499426
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02628045
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02628045
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02347487
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01711935
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01695492
92IRF1_19129219_ChIP-ChIP_H3396_Human1.01451582
93CJUN_26792858_Chip-Seq_BT549_Human1.00227488
94FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00219530
95FOXA1_25329375_ChIP-Seq_VCAP_Human1.00219530
96FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99919946
97GATA3_26560356_Chip-Seq_TH2_Human0.99386021
98JUN_21703547_ChIP-Seq_K562_Human0.99361513
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.97899183
100SALL4_22934838_ChIP-ChIP_CD34+_Human0.97668657

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage3.73746647
2MP0002138_abnormal_hepatobiliary_system3.57805028
3MP0000569_abnormal_digit_pigmentation3.45040144
4MP0001873_stomach_inflammation3.30166666
5MP0001348_abnormal_lacrimal_gland3.20542228
6MP0000372_irregular_coat_pigmentation2.84690930
7MP0003011_delayed_dark_adaptation2.61780333
8MP0002102_abnormal_ear_morphology2.55415340
9MP0003195_calcinosis2.45102175
10MP0001879_abnormal_lymphatic_vessel2.26229021
11MP0005551_abnormal_eye_electrophysiolog2.22769990
12MP0004885_abnormal_endolymph2.17771191
13MP0002736_abnormal_nociception_after2.12185552
14MP0003646_muscle_fatigue1.93431577
15MP0003787_abnormal_imprinting1.91325235
16MP0004147_increased_porphyrin_level1.88947904
17MP0010368_abnormal_lymphatic_system1.87029681
18MP0004484_altered_response_of1.85883303
19MP0008872_abnormal_physiological_respon1.84127879
20MP0003880_abnormal_central_pattern1.80566991
21MP0008875_abnormal_xenobiotic_pharmacok1.78917764
22MP0008057_abnormal_DNA_replication1.71157282
23MP0004782_abnormal_surfactant_physiolog1.69210608
24MP0001485_abnormal_pinna_reflex1.67997543
25MP0004742_abnormal_vestibular_system1.66145985
26MP0003183_abnormal_peptide_metabolism1.62399126
27MP0003786_premature_aging1.62151077
28MP0005167_abnormal_blood-brain_barrier1.58151116
29MP0000465_gastrointestinal_hemorrhage1.55361118
30MP0002009_preneoplasia1.53554445
31MP0005310_abnormal_salivary_gland1.52657101
32MP0000613_abnormal_salivary_gland1.51822506
33MP0002254_reproductive_system_inflammat1.51144700
34MP0005253_abnormal_eye_physiology1.49820276
35MP0001968_abnormal_touch/_nociception1.46655329
36MP0009384_cardiac_valve_regurgitation1.45077625
37MP0008058_abnormal_DNA_repair1.44396328
38MP0005171_absent_coat_pigmentation1.41434160
39MP0006082_CNS_inflammation1.34300432
40MP0003943_abnormal_hepatobiliary_system1.31433678
41MP0006292_abnormal_olfactory_placode1.31036983
42MP0008775_abnormal_heart_ventricle1.30086895
43MP0005367_renal/urinary_system_phenotyp1.29761742
44MP0000516_abnormal_urinary_system1.29761742
45MP0008789_abnormal_olfactory_epithelium1.28109665
46MP0001986_abnormal_taste_sensitivity1.27087857
47MP0004215_abnormal_myocardial_fiber1.19178875
48MP0009780_abnormal_chondrocyte_physiolo1.17623755
49MP0003950_abnormal_plasma_membrane1.13171055
50MP0003567_abnormal_fetal_cardiomyocyte1.12109599
51MP0009840_abnormal_foam_cell1.10419051
52MP0006276_abnormal_autonomic_nervous1.10301337
53MP0002876_abnormal_thyroid_physiology1.09575564
54MP0003718_maternal_effect1.08943924
55MP0000427_abnormal_hair_cycle1.08881255
56MP0003878_abnormal_ear_physiology1.08690856
57MP0005377_hearing/vestibular/ear_phenot1.08690856
58MP0001835_abnormal_antigen_presentation1.07038567
59MP0005174_abnormal_tail_pigmentation1.06187756
60MP0001790_abnormal_immune_system1.04907204
61MP0005387_immune_system_phenotype1.04907204
62MP0005503_abnormal_tendon_morphology1.03186996
63MP0002127_abnormal_cardiovascular_syste1.00856387
64MP0002938_white_spotting1.00766231
65MP0002933_joint_inflammation1.00011597
66MP0006072_abnormal_retinal_apoptosis0.99854756
67MP0001486_abnormal_startle_reflex0.98219565
68MP0000767_abnormal_smooth_muscle0.96761107
69MP0002090_abnormal_vision0.96655126
70MP0001324_abnormal_eye_pigmentation0.96414666
71MP0003121_genomic_imprinting0.94217372
72MP0005187_abnormal_penis_morphology0.89043686
73MP0002282_abnormal_trachea_morphology0.88142327
74MP0005195_abnormal_posterior_eye0.85899543
75MP0002295_abnormal_pulmonary_circulatio0.83803367
76MP0003186_abnormal_redox_activity0.82276848
77MP0008877_abnormal_DNA_methylation0.82149308
78MP0001919_abnormal_reproductive_system0.81566160
79MP0001764_abnormal_homeostasis0.81563725
80MP0005389_reproductive_system_phenotype0.80694130
81MP0006138_congestive_heart_failure0.79068008
82MP0000026_abnormal_inner_ear0.79067629
83MP0005084_abnormal_gallbladder_morpholo0.78081739
84MP0002272_abnormal_nervous_system0.76857263
85MP0009745_abnormal_behavioral_response0.74627559
86MP0005395_other_phenotype0.73721539
87MP0006036_abnormal_mitochondrial_physio0.73589408
88MP0001800_abnormal_humoral_immune0.71489746
89MP0001293_anophthalmia0.70476577
90MP0001963_abnormal_hearing_physiology0.68022315
91MP0001119_abnormal_female_reproductive0.67627590
92MP0002233_abnormal_nose_morphology0.66704714
93MP0002751_abnormal_autonomic_nervous0.66420608
94MP0001502_abnormal_circadian_rhythm0.65742844
95MP0002168_other_aberrant_phenotype0.63440204
96MP0010678_abnormal_skin_adnexa0.62776459
97MP0005671_abnormal_response_to0.61798680
98MP0001853_heart_inflammation0.60197674
99MP0005000_abnormal_immune_tolerance0.57403583
100MP0000647_abnormal_sebaceous_gland0.56654844

Predicted human phenotypes

RankGene SetZ-score
1Chronic diarrhea (HP:0002028)3.85376989
2Occipital encephalocele (HP:0002085)3.26781844
3Chorioretinal atrophy (HP:0000533)3.25550267
4Abnormal biliary tract physiology (HP:0012439)3.19268926
5Bile duct proliferation (HP:0001408)3.19268926
6Pancreatic cysts (HP:0001737)2.97893314
7Pancreatic fibrosis (HP:0100732)2.86318651
8Chronic hepatic failure (HP:0100626)2.81876337
9Abnormality of B cell number (HP:0010975)2.75360751
10Bilateral microphthalmos (HP:0007633)2.74600399
11Aplasia/Hypoplasia of the spleen (HP:0010451)2.74050942
12IgG deficiency (HP:0004315)2.71921487
13True hermaphroditism (HP:0010459)2.70191232
14Abnormality of DNA repair (HP:0003254)2.69604003
15B lymphocytopenia (HP:0010976)2.57702467
16Dynein arm defect of respiratory motile cilia (HP:0012255)2.47505513
17Absent/shortened dynein arms (HP:0200106)2.47505513
18Absent eyebrow (HP:0002223)2.46491629
19Thyroiditis (HP:0100646)2.42208845
20Methylmalonic aciduria (HP:0012120)2.41917905
21Hematochezia (HP:0002573)2.39079182
22Parakeratosis (HP:0001036)2.32035493
23Constricted visual fields (HP:0001133)2.30071199
24Hypomagnesemia (HP:0002917)2.30069427
25Asplenia (HP:0001746)2.29703446
26Anophthalmia (HP:0000528)2.28479108
27Abnormality of the renal cortex (HP:0011035)2.28435342
28Keratoconus (HP:0000563)2.27546404
29Increased corneal curvature (HP:0100692)2.27546404
30Abnormality of the renal medulla (HP:0100957)2.27367414
31Conjugated hyperbilirubinemia (HP:0002908)2.26622562
32Hypoplastic pelvis (HP:0008839)2.24197827
33Abnormality of the ischium (HP:0003174)2.21257011
34Nephronophthisis (HP:0000090)2.20131880
35Hyperglycinemia (HP:0002154)2.19843265
36Ectopic kidney (HP:0000086)2.18877797
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.18484691
38Hypoplastic ischia (HP:0003175)2.18078409
39Hypophosphatemic rickets (HP:0004912)2.17216414
40Optic disc pallor (HP:0000543)2.16242151
41Recurrent sinusitis (HP:0011108)2.14329780
42Bilateral sensorineural hearing impairment (HP:0008619)2.12455301
43Progressive inability to walk (HP:0002505)2.11745894
44Congenital stationary night blindness (HP:0007642)2.11126293
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.10623337
46Colon cancer (HP:0003003)2.07979125
47Cone-rod dystrophy (HP:0000548)2.06250783
48Attenuation of retinal blood vessels (HP:0007843)2.03142527
49Hyperglycinuria (HP:0003108)2.03056164
50Abnormal respiratory epithelium morphology (HP:0012253)2.01363474
51Abnormal respiratory motile cilium morphology (HP:0005938)2.01363474
52Disproportionate short-trunk short stature (HP:0003521)2.01218659
53Polyuria (HP:0000103)1.99643170
54Molar tooth sign on MRI (HP:0002419)1.97182946
55Abnormality of midbrain morphology (HP:0002418)1.97182946
56Severe combined immunodeficiency (HP:0004430)1.96944828
57Volvulus (HP:0002580)1.95707892
58Short tibia (HP:0005736)1.92421384
59Action tremor (HP:0002345)1.91777628
60Inability to walk (HP:0002540)1.91744061
61Bell-shaped thorax (HP:0001591)1.90698301
62IgA deficiency (HP:0002720)1.90691706
63Anencephaly (HP:0002323)1.90125312
64Gaze-evoked nystagmus (HP:0000640)1.86265541
65Megalencephaly (HP:0001355)1.85838187
66Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85033021
67Ectropion (HP:0000656)1.84969376
68Abnormal ciliary motility (HP:0012262)1.84904940
69Dry hair (HP:0011359)1.83738103
70Facial diplegia (HP:0001349)1.82704363
71Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82664115
72Abnormal drinking behavior (HP:0030082)1.81713433
73Polydipsia (HP:0001959)1.81713433
74Pancreatic islet-cell hyperplasia (HP:0004510)1.81492504
75Pendular nystagmus (HP:0012043)1.81490090
76Spastic diplegia (HP:0001264)1.80733729
77Congenital hepatic fibrosis (HP:0002612)1.80039063
78Abnormal lung lobation (HP:0002101)1.79035978
79Portal hypertension (HP:0001409)1.78957744
80Stomach cancer (HP:0012126)1.78937939
81Increased CSF lactate (HP:0002490)1.78217877
82Abnormality of the ileum (HP:0001549)1.77946845
83Focal motor seizures (HP:0011153)1.77539843
84Medial flaring of the eyebrow (HP:0010747)1.77334799
85Large for gestational age (HP:0001520)1.77288533
86Aplasia/Hypoplasia of the scapulae (HP:0006713)1.76201532
87Hypoplastic scapulae (HP:0000882)1.76201532
88Fibular aplasia (HP:0002990)1.76028734
89Abnormality of chromosome stability (HP:0003220)1.75817886
90Methylmalonic acidemia (HP:0002912)1.74119935
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.72015510
92Prostate neoplasm (HP:0100787)1.71783777
93Tubular atrophy (HP:0000092)1.71753397
94Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71073232
95Stenosis of the external auditory canal (HP:0000402)1.69981897
96Absent eyelashes (HP:0000561)1.68634054
97Furrowed tongue (HP:0000221)1.68305258
98Neutropenia (HP:0001875)1.68274749
99Cupped ear (HP:0000378)1.68096021
100Meckel diverticulum (HP:0002245)1.66573320

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.24938548
2ACVR1B4.22887180
3PBK3.09834610
4BMPR1B3.04838005
5MST42.97906658
6FRK2.72511434
7EIF2AK32.55277693
8MAP4K22.46010730
9WNK32.23454731
10STK392.10474584
11MKNK22.05581850
12NUAK12.05308385
13GRK11.84440665
14TRIM281.84162115
15TLK11.83923123
16TGFBR21.76848442
17PLK21.75687344
18PINK11.71949641
19PDK21.61081458
20TGFBR11.50908525
21TAOK31.46727193
22NEK91.40515469
23TEC1.40445790
24ADRBK21.38167263
25INSRR1.37630766
26CSNK1G11.32836287
27MKNK11.30389032
28TNIK1.27483205
29SRPK11.23240556
30PIK3CG1.22558073
31VRK21.21057583
32OXSR11.20651317
33ERBB31.19254710
34PTK2B1.14251417
35CSNK1G31.13735162
36WNK41.09147208
37VRK11.08433863
38FER1.08025560
39ADRBK11.07135562
40MAP3K131.06412015
41NLK1.05895813
42BRD41.04537627
43CSNK1A1L1.01572588
44CASK1.01410697
45KDR1.01345314
46CSNK1G21.00008005
47CDK80.99813855
48BMPR20.95517690
49PAK30.93610783
50PLK30.92687938
51MOS0.91325556
52EIF2AK10.90280490
53NEK10.83194989
54BCR0.81943749
55GRK50.81669754
56STK100.80903651
57MET0.78063218
58BRSK20.76601378
59ZAK0.72334735
60PRKCE0.72081801
61MARK10.64268761
62MST1R0.62445419
63DYRK30.61401594
64PAK60.59380725
65KSR10.57549913
66SIK30.57074689
67IKBKB0.55842863
68BCKDK0.53995925
69FES0.52307797
70ITK0.51871750
71IGF1R0.50072493
72RAF10.48514943
73NTRK20.45509579
74CSF1R0.45257863
75EPHA40.44865753
76WEE10.44171919
77CSNK1A10.42990399
78BUB10.42563255
79TAF10.42339642
80PRKCI0.42264822
81EIF2AK20.41619691
82MAP2K60.40934164
83DYRK20.40245354
84IRAK10.40053477
85CAMK2D0.36443284
86PRKCQ0.35143018
87PRKG10.34519056
88ROCK10.33758263
89STK38L0.32753073
90MAP3K120.32236928
91RPS6KA40.31103819
92CAMK2A0.30795234
93MELK0.29729265
94EPHA30.28874372
95MAPKAPK50.27933168
96GSK3A0.25753229
97PLK40.25603249
98TNK20.24296957
99PLK10.22494391
100MAPK130.22449696

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.96722677
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.73685498
3Allograft rejection_Homo sapiens_hsa053303.15179158
4Autoimmune thyroid disease_Homo sapiens_hsa053203.09551616
5Proteasome_Homo sapiens_hsa030502.82757525
6Phototransduction_Homo sapiens_hsa047442.81068384
7Protein export_Homo sapiens_hsa030602.77703044
8Non-homologous end-joining_Homo sapiens_hsa034502.75218694
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.67297952
10RNA polymerase_Homo sapiens_hsa030202.46731961
11Basal transcription factors_Homo sapiens_hsa030222.27837091
12Caffeine metabolism_Homo sapiens_hsa002322.20441059
13Fanconi anemia pathway_Homo sapiens_hsa034602.03575964
14Homologous recombination_Homo sapiens_hsa034401.79723883
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76345883
16Primary immunodeficiency_Homo sapiens_hsa053401.71900663
17Linoleic acid metabolism_Homo sapiens_hsa005911.70531901
18Steroid biosynthesis_Homo sapiens_hsa001001.68083185
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56480139
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50247676
21RNA degradation_Homo sapiens_hsa030181.49242848
22Nucleotide excision repair_Homo sapiens_hsa034201.43732781
23Propanoate metabolism_Homo sapiens_hsa006401.39008146
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37344487
25Tryptophan metabolism_Homo sapiens_hsa003801.35769529
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33475922
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30918163
28Ether lipid metabolism_Homo sapiens_hsa005651.28739146
29Graft-versus-host disease_Homo sapiens_hsa053321.25761285
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20735927
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18414579
32Mismatch repair_Homo sapiens_hsa034301.08704318
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02903492
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02872075
35Nitrogen metabolism_Homo sapiens_hsa009101.02493229
36Type I diabetes mellitus_Homo sapiens_hsa049401.02040452
37Hematopoietic cell lineage_Homo sapiens_hsa046401.00510755
38Oxidative phosphorylation_Homo sapiens_hsa001900.99749707
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93989619
40One carbon pool by folate_Homo sapiens_hsa006700.89935781
41p53 signaling pathway_Homo sapiens_hsa041150.89320260
42Parkinsons disease_Homo sapiens_hsa050120.88413076
43Peroxisome_Homo sapiens_hsa041460.88069244
44Rheumatoid arthritis_Homo sapiens_hsa053230.86834241
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86686944
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86553248
47Pyrimidine metabolism_Homo sapiens_hsa002400.85120163
48Selenocompound metabolism_Homo sapiens_hsa004500.84925501
49Fatty acid elongation_Homo sapiens_hsa000620.84790876
50Base excision repair_Homo sapiens_hsa034100.84447642
51Fatty acid biosynthesis_Homo sapiens_hsa000610.81711629
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78138221
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.77198480
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.76465022
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75844264
56RNA transport_Homo sapiens_hsa030130.72146511
57Viral myocarditis_Homo sapiens_hsa054160.67785463
58Butanoate metabolism_Homo sapiens_hsa006500.66770578
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64902984
60Hedgehog signaling pathway_Homo sapiens_hsa043400.64544797
61Arachidonic acid metabolism_Homo sapiens_hsa005900.64402749
62Huntingtons disease_Homo sapiens_hsa050160.62469634
63Thyroid hormone synthesis_Homo sapiens_hsa049180.61675103
64Serotonergic synapse_Homo sapiens_hsa047260.60553992
65Purine metabolism_Homo sapiens_hsa002300.59635418
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57695862
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57501321
68Ovarian steroidogenesis_Homo sapiens_hsa049130.57317529
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57263767
70Basal cell carcinoma_Homo sapiens_hsa052170.54728918
71Circadian rhythm_Homo sapiens_hsa047100.54489232
72Dorso-ventral axis formation_Homo sapiens_hsa043200.54095512
73ABC transporters_Homo sapiens_hsa020100.50101926
74Glycerolipid metabolism_Homo sapiens_hsa005610.49887752
75Retinol metabolism_Homo sapiens_hsa008300.48425821
76beta-Alanine metabolism_Homo sapiens_hsa004100.48334691
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45654076
78Olfactory transduction_Homo sapiens_hsa047400.45603033
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44132827
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43947882
81TGF-beta signaling pathway_Homo sapiens_hsa043500.43881732
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43014175
83Morphine addiction_Homo sapiens_hsa050320.42104749
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40923113
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38927113
86Glutathione metabolism_Homo sapiens_hsa004800.38915650
87Complement and coagulation cascades_Homo sapiens_hsa046100.37671975
88Taste transduction_Homo sapiens_hsa047420.35616382
89Metabolic pathways_Homo sapiens_hsa011000.35197231
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33979530
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.33836788
92T cell receptor signaling pathway_Homo sapiens_hsa046600.33835792
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33710006
94Fatty acid metabolism_Homo sapiens_hsa012120.31151499
95Dopaminergic synapse_Homo sapiens_hsa047280.30724169
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28723851
97Chemical carcinogenesis_Homo sapiens_hsa052040.28493789
98Sulfur metabolism_Homo sapiens_hsa009200.27143159
99Systemic lupus erythematosus_Homo sapiens_hsa053220.25317468
100Antigen processing and presentation_Homo sapiens_hsa046120.24982545

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