PDCL3P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of inclusion body assembly (GO:0090084)7.98572155
2protein refolding (GO:0042026)7.00837827
3negative regulation of mesenchymal cell apoptotic process (GO:2001054)6.23741658
4neuron fate determination (GO:0048664)5.66507120
5auditory receptor cell differentiation (GO:0042491)5.02968337
6axon ensheathment in central nervous system (GO:0032291)4.83787636
7central nervous system myelination (GO:0022010)4.83787636
8regulation of mesenchymal cell apoptotic process (GO:2001053)4.77677658
9nephron epithelium morphogenesis (GO:0072088)4.51553607
10nephron tubule morphogenesis (GO:0072078)4.51553607
11cellular ketone body metabolic process (GO:0046950)4.38404649
12regulation of inclusion body assembly (GO:0090083)4.33848501
13tolerance induction (GO:0002507)4.28544571
14negative regulation of oligodendrocyte differentiation (GO:0048715)4.27378745
15regulation of chronic inflammatory response (GO:0002676)4.23174991
16regulation of isotype switching to IgG isotypes (GO:0048302)4.17764534
17neuronal stem cell maintenance (GO:0097150)4.13458139
18production of molecular mediator of immune response (GO:0002440)4.02114797
19chaperone mediated protein folding requiring cofactor (GO:0051085)4.01595701
20negative regulation of astrocyte differentiation (GO:0048712)4.00435273
21regulation of microtubule-based movement (GO:0060632)4.00304704
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.95611548
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.95611548
24positive regulation of interleukin-17 production (GO:0032740)3.91962199
25ketone body metabolic process (GO:1902224)3.87227027
26cytokine production involved in immune response (GO:0002367)3.84272665
27pattern specification involved in kidney development (GO:0061004)3.78023353
28otic vesicle formation (GO:0030916)3.75756362
29nephron tubule formation (GO:0072079)3.68082191
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.67426606
31negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.62888802
32CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.59858781
33cellular response to interleukin-15 (GO:0071350)3.56597399
34mitochondrion morphogenesis (GO:0070584)3.51372166
35mannosylation (GO:0097502)3.48143897
36radial glial cell differentiation (GO:0060019)3.46086441
37multicellular organism reproduction (GO:0032504)3.45141063
38forebrain neuron differentiation (GO:0021879)3.44976930
39positive regulation of natural killer cell differentiation (GO:0032825)3.42592433
40response to interleukin-15 (GO:0070672)3.40071015
41DNA ligation (GO:0006266)3.36562744
42astrocyte differentiation (GO:0048708)3.36138130
43rRNA catabolic process (GO:0016075)3.35904090
44positive regulation of response to oxidative stress (GO:1902884)3.35784181
45positive regulation of cellular response to oxidative stress (GO:1900409)3.35784181
46negative regulation of T cell differentiation in thymus (GO:0033085)3.32656164
47mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.30959823
48cilium or flagellum-dependent cell motility (GO:0001539)3.26471576
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.17690056
50regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.10294082
51water-soluble vitamin biosynthetic process (GO:0042364)3.05987273
52S-adenosylmethionine metabolic process (GO:0046500)3.05921629
53cellular response to interferon-beta (GO:0035458)3.05916606
54positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.02306829
55positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.01473747
56meiosis I (GO:0007127)2.98184445
57negative regulation of glial cell differentiation (GO:0045686)2.97476322
58response to methylmercury (GO:0051597)2.97413758
59limb bud formation (GO:0060174)2.91618244
60male meiosis I (GO:0007141)2.90515285
61renal tubule morphogenesis (GO:0061333)2.87892992
62proteasome assembly (GO:0043248)2.86993304
63lysosome localization (GO:0032418)2.85706189
64preassembly of GPI anchor in ER membrane (GO:0016254)2.84649077
65regulation of podosome assembly (GO:0071801)2.82563078
66ATP synthesis coupled proton transport (GO:0015986)2.81213962
67energy coupled proton transport, down electrochemical gradient (GO:0015985)2.81213962
68regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.80659106
69regulation of immunoglobulin secretion (GO:0051023)2.76126805
70positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.74898415
71adenosine metabolic process (GO:0046085)2.74182038
72lipopolysaccharide biosynthetic process (GO:0009103)2.72681647
73heart valve formation (GO:0003188)2.72606482
74negative regulation of T-helper cell differentiation (GO:0045623)2.72599403
75negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.72599403
76positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.68709598
77positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)2.67464407
78negative regulation of acute inflammatory response (GO:0002674)2.67429918
79positive regulation of chemokine biosynthetic process (GO:0045080)2.66480102
80bundle of His cell to Purkinje myocyte communication (GO:0086069)2.64745670
81response to interferon-beta (GO:0035456)2.64466865
82DNA deamination (GO:0045006)2.62209096
83positive regulation of Notch signaling pathway (GO:0045747)2.62190908
84positive regulation of natural killer cell mediated immunity (GO:0002717)2.61538479
85regulation of hydrogen peroxide metabolic process (GO:0010310)2.59664032
86mitotic cell cycle arrest (GO:0071850)2.58907621
87sleep (GO:0030431)2.58373137
88response to misfolded protein (GO:0051788)2.57016990
89misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.55043258
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.54957760
91regulation of oligodendrocyte differentiation (GO:0048713)2.51596388
92anterograde axon cargo transport (GO:0008089)2.50869970
93sperm capacitation (GO:0048240)2.49386051
94negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.49321695
95notochord development (GO:0030903)2.49254799
96positive regulation of male gonad development (GO:2000020)2.48357921
97regulation of MHC class II biosynthetic process (GO:0045346)2.47741644
98positive regulation of interleukin-10 production (GO:0032733)2.45791608
99anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.44885333
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.44383273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.36428871
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.73107125
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.65264491
4TAF15_26573619_Chip-Seq_HEK293_Human3.63449859
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.55108440
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.23947368
7VDR_22108803_ChIP-Seq_LS180_Human3.04881092
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.72796168
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.62739576
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.57446907
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.43437286
12ZNF274_21170338_ChIP-Seq_K562_Hela2.25853481
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21449211
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13983126
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.10996486
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05455213
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93073042
18FOXA1_27270436_Chip-Seq_PROSTATE_Human1.89910656
19FOXA1_25329375_ChIP-Seq_VCAP_Human1.89910656
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.89710040
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.87785410
22MYC_18940864_ChIP-ChIP_HL60_Human1.78366734
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74094619
24MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.73787590
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71301412
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64878733
27GATA3_26560356_Chip-Seq_TH2_Human1.63924491
28IRF1_19129219_ChIP-ChIP_H3396_Human1.57157293
29TP53_22573176_ChIP-Seq_HFKS_Human1.56243882
30LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53574223
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.52566220
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51898048
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50856895
34EWS_26573619_Chip-Seq_HEK293_Human1.48889513
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43971922
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43971922
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43971922
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40831468
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.40282292
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.40249218
41MYC_19829295_ChIP-Seq_ESCs_Human1.39831261
42VDR_23849224_ChIP-Seq_CD4+_Human1.39358065
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38183578
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37681572
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37063041
46FUS_26573619_Chip-Seq_HEK293_Human1.35398227
47ER_23166858_ChIP-Seq_MCF-7_Human1.35275262
48HOXB7_26014856_ChIP-Seq_BT474_Human1.35048838
49AR_20517297_ChIP-Seq_VCAP_Human1.34880539
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34660919
51FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33548601
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.31199370
53TAF2_19829295_ChIP-Seq_ESCs_Human1.31158550
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30667019
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28234623
56TCF4_22108803_ChIP-Seq_LS180_Human1.22829443
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21138508
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19553951
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18003033
60CBP_20019798_ChIP-Seq_JUKART_Human1.17605272
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17605272
62VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17516840
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.17196193
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.16120975
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16005562
66RNF2_27304074_Chip-Seq_NSC_Mouse1.14163644
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13931538
68P300_19829295_ChIP-Seq_ESCs_Human1.12244272
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.11901084
70RUNX_20019798_ChIP-Seq_JUKART_Human1.09568742
71ELK1_19687146_ChIP-ChIP_HELA_Human1.09528179
72GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08997559
73ERG_20517297_ChIP-Seq_VCAP_Human1.05194525
74GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04315300
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02994708
76MYB_26560356_Chip-Seq_TH2_Human1.02474054
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02402955
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02321791
79IRF8_22096565_ChIP-ChIP_GC-B_Human1.02160884
80PHF8_20622853_ChIP-Seq_HELA_Human1.00617217
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99579027
82TAL1_26923725_Chip-Seq_HPCs_Mouse0.98948726
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98763285
84FOXP3_21729870_ChIP-Seq_TREG_Human0.98662327
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.97595152
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.97327577
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96787410
88AR_25329375_ChIP-Seq_VCAP_Human0.95673947
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.95671352
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95653013
91GATA3_26560356_Chip-Seq_TH1_Human0.93878881
92FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93838258
93NANOG_19829295_ChIP-Seq_ESCs_Human0.92550043
94SOX2_19829295_ChIP-Seq_ESCs_Human0.92550043
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92121939
96GATA6_21074721_ChIP-Seq_CACO-2_Human0.92017657
97DCP1A_22483619_ChIP-Seq_HELA_Human0.91425582
98GBX2_23144817_ChIP-Seq_PC3_Human0.91288346
99WDR5_24793694_ChIP-Seq_LNCAP_Human0.89418699
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89115661

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system3.93671655
2MP0004147_increased_porphyrin_level3.60289711
3MP0004885_abnormal_endolymph3.53389045
4MP0001873_stomach_inflammation3.01817417
5MP0004742_abnormal_vestibular_system2.94152310
6MP0008058_abnormal_DNA_repair2.91368052
7MP0002102_abnormal_ear_morphology2.88390658
8MP0009384_cardiac_valve_regurgitation2.72261034
9MP0008007_abnormal_cellular_replicative2.68931019
10MP0005084_abnormal_gallbladder_morpholo2.65237983
11MP0002638_abnormal_pupillary_reflex2.60664932
12MP0002736_abnormal_nociception_after2.52738406
13MP0001485_abnormal_pinna_reflex2.50540814
14MP0006072_abnormal_retinal_apoptosis2.45207919
15MP0001835_abnormal_antigen_presentation2.38131454
16MP0003136_yellow_coat_color2.32157328
17MP0005671_abnormal_response_to2.26183463
18MP0002277_abnormal_respiratory_mucosa2.23194782
19MP0008872_abnormal_physiological_respon2.22251430
20MP0002282_abnormal_trachea_morphology2.21536432
21MP0001968_abnormal_touch/_nociception2.18383632
22MP0000465_gastrointestinal_hemorrhage2.10485642
23MP0004145_abnormal_muscle_electrophysio2.10042701
24MP0001984_abnormal_olfaction1.96084090
25MP0000749_muscle_degeneration1.89197646
26MP0008877_abnormal_DNA_methylation1.78444274
27MP0005253_abnormal_eye_physiology1.74140680
28MP0004142_abnormal_muscle_tone1.67902889
29MP0005000_abnormal_immune_tolerance1.58407670
30MP0003763_abnormal_thymus_physiology1.54966206
31MP0005551_abnormal_eye_electrophysiolog1.52946915
32MP0002928_abnormal_bile_duct1.48137436
33MP0001800_abnormal_humoral_immune1.47804419
34MP0001790_abnormal_immune_system1.45860707
35MP0005387_immune_system_phenotype1.45860707
36MP0005646_abnormal_pituitary_gland1.43964955
37MP0003718_maternal_effect1.41533093
38MP0010094_abnormal_chromosome_stability1.41122670
39MP0001764_abnormal_homeostasis1.35410154
40MP0002653_abnormal_ependyma_morphology1.33202784
41MP0003878_abnormal_ear_physiology1.32061713
42MP0005377_hearing/vestibular/ear_phenot1.32061713
43MP0008875_abnormal_xenobiotic_pharmacok1.30767927
44MP0010368_abnormal_lymphatic_system1.28948852
45MP0001986_abnormal_taste_sensitivity1.28296031
46MP0006082_CNS_inflammation1.26722689
47MP0000343_altered_response_to1.25520689
48MP0002822_catalepsy1.20969623
49MP0003806_abnormal_nucleotide_metabolis1.19949240
50MP0001919_abnormal_reproductive_system1.19837767
51MP0001502_abnormal_circadian_rhythm1.18915620
52MP0003866_abnormal_defecation1.14643130
53MP0001348_abnormal_lacrimal_gland1.13766470
54MP0000026_abnormal_inner_ear1.06548303
55MP0002723_abnormal_immune_serum1.02312715
56MP0002452_abnormal_antigen_presenting0.98372735
57MP0001486_abnormal_startle_reflex0.97831848
58MP0009764_decreased_sensitivity_to0.96288831
59MP0005167_abnormal_blood-brain_barrier0.95909367
60MP0009745_abnormal_behavioral_response0.93342846
61MP0003195_calcinosis0.92799897
62MP0000049_abnormal_middle_ear0.91101750
63MP0005310_abnormal_salivary_gland0.86281290
64MP0002420_abnormal_adaptive_immunity0.86146556
65MP0005584_abnormal_enzyme/coenzyme_acti0.86084177
66MP0002876_abnormal_thyroid_physiology0.82982665
67MP0001819_abnormal_immune_cell0.81107706
68MP0001851_eye_inflammation0.78927925
69MP0005391_vision/eye_phenotype0.77898792
70MP0000685_abnormal_immune_system0.76037666
71MP0001963_abnormal_hearing_physiology0.75699588
72MP0005195_abnormal_posterior_eye0.75249219
73MP0003880_abnormal_central_pattern0.74731562
74MP0001270_distended_abdomen0.74492561
75MP0001929_abnormal_gametogenesis0.72137920
76MP0004510_myositis0.69577274
77MP0002249_abnormal_larynx_morphology0.68313462
78MP0003011_delayed_dark_adaptation0.65478879
79MP0002398_abnormal_bone_marrow0.64793014
80MP0003638_abnormal_response/metabolism_0.63424360
81MP0009785_altered_susceptibility_to0.63414117
82MP0002166_altered_tumor_susceptibility0.62479344
83MP0001243_abnormal_dermal_layer0.62076023
84MP0000716_abnormal_immune_system0.61847313
85MP0000516_abnormal_urinary_system0.61423909
86MP0005367_renal/urinary_system_phenotyp0.61423909
87MP0009333_abnormal_splenocyte_physiolog0.60528589
88MP0003724_increased_susceptibility_to0.58989490
89MP0005389_reproductive_system_phenotype0.57914978
90MP0002557_abnormal_social/conspecific_i0.57548414
91MP0000689_abnormal_spleen_morphology0.57456846
92MP0003137_abnormal_impulse_conducting0.57042206
93MP0002272_abnormal_nervous_system0.56033590
94MP0002693_abnormal_pancreas_physiology0.55458313
95MP0005075_abnormal_melanosome_morpholog0.55345980
96MP0001299_abnormal_eye_distance/0.54608288
97MP0001188_hyperpigmentation0.54406941
98MP0002405_respiratory_system_inflammati0.54048313
99MP0004043_abnormal_pH_regulation0.54041495
100MP0009840_abnormal_foam_cell0.53854371

Predicted human phenotypes

RankGene SetZ-score
111 pairs of ribs (HP:0000878)6.07478528
2Hypoplastic iliac wings (HP:0002866)4.59862830
3True hermaphroditism (HP:0010459)4.34677728
4Molar tooth sign on MRI (HP:0002419)3.53724725
5Abnormality of midbrain morphology (HP:0002418)3.53724725
6Severe muscular hypotonia (HP:0006829)3.23988616
7Missing ribs (HP:0000921)3.21458970
8Type I transferrin isoform profile (HP:0003642)3.20848817
9Congenital, generalized hypertrichosis (HP:0004540)3.15274131
10Morphological abnormality of the middle ear (HP:0008609)3.12119527
11Acute necrotizing encephalopathy (HP:0006965)3.06736933
12Morphological abnormality of the inner ear (HP:0011390)3.04670941
13Type II lissencephaly (HP:0007260)2.99259813
14Tubular atrophy (HP:0000092)2.98729573
15Exertional dyspnea (HP:0002875)2.93270108
16Cerebellar dysplasia (HP:0007033)2.89072963
17Abnormal ciliary motility (HP:0012262)2.87373065
18Abnormal respiratory epithelium morphology (HP:0012253)2.78671246
19Abnormal respiratory motile cilium morphology (HP:0005938)2.78671246
20Abnormality of the pons (HP:0007361)2.77728711
21Progressive microcephaly (HP:0000253)2.76077325
22Hypoplasia of the pons (HP:0012110)2.74792947
23Medial flaring of the eyebrow (HP:0010747)2.73491176
24Concave nail (HP:0001598)2.72779159
25Increased hepatocellular lipid droplets (HP:0006565)2.72448055
26Increased CSF lactate (HP:0002490)2.69684012
27Chronic sinusitis (HP:0011109)2.68087216
28Acute encephalopathy (HP:0006846)2.67931163
29Mitochondrial inheritance (HP:0001427)2.63436752
30Pancreatic cysts (HP:0001737)2.63206358
31Type 2 muscle fiber atrophy (HP:0003554)2.61120887
32Abnormal albumin level (HP:0012116)2.57289040
33Hypoalbuminemia (HP:0003073)2.57289040
34Abnormal mitochondria in muscle tissue (HP:0008316)2.55020159
35Aplasia/Hypoplasia of the sternum (HP:0006714)2.54721192
36Disproportionate short-trunk short stature (HP:0003521)2.52864109
37Cerebral hemorrhage (HP:0001342)2.49806151
38Pancreatic fibrosis (HP:0100732)2.48251435
39Hypoproteinemia (HP:0003075)2.47688083
40Thin ribs (HP:0000883)2.47454052
41Progressive macrocephaly (HP:0004481)2.45891578
42Progressive sensorineural hearing impairment (HP:0000408)2.45593581
43Lipid accumulation in hepatocytes (HP:0006561)2.42043634
44Abnormal respiratory motile cilium physiology (HP:0012261)2.39618068
45Dry hair (HP:0011359)2.37458553
46Mesangial abnormality (HP:0001966)2.36060668
47Fibular hypoplasia (HP:0003038)2.33707987
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.31185381
49Delayed CNS myelination (HP:0002188)2.27397346
50Muscle fiber atrophy (HP:0100295)2.22205679
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20722519
52Abnormal protein N-linked glycosylation (HP:0012347)2.20722519
53Abnormal protein glycosylation (HP:0012346)2.20722519
54Abnormal glycosylation (HP:0012345)2.20722519
55Hypoplastic ilia (HP:0000946)2.20007706
56Diaphragmatic weakness (HP:0009113)2.16178787
57Sex reversal (HP:0012245)2.15465393
58Abnormal sex determination (HP:0012244)2.15465393
59Rhinitis (HP:0012384)2.14392089
60Hypoglycemic seizures (HP:0002173)2.13023232
61Congenital stationary night blindness (HP:0007642)2.12178496
62Hepatocellular necrosis (HP:0001404)2.11604923
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11066364
64Abnormality of the wing of the ilium (HP:0011867)2.06723487
65Optic disc pallor (HP:0000543)2.05811096
66Birth length less than 3rd percentile (HP:0003561)2.05230904
67Respiratory distress (HP:0002098)2.03598762
68Chronic diarrhea (HP:0002028)2.02815300
69Hepatic necrosis (HP:0002605)2.02709712
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02435079
71Renal Fanconi syndrome (HP:0001994)2.01692824
72Bronchomalacia (HP:0002780)2.01399273
73Large for gestational age (HP:0001520)1.98998421
74Neonatal short-limb short stature (HP:0008921)1.96510672
75Increased serum pyruvate (HP:0003542)1.95335288
76Increased intramyocellular lipid droplets (HP:0012240)1.95230954
77Hypoglycemic coma (HP:0001325)1.94799541
78Abnormality of male internal genitalia (HP:0000022)1.93167836
79Gonadotropin excess (HP:0000837)1.90405756
80Nephronophthisis (HP:0000090)1.89956874
81Chronic otitis media (HP:0000389)1.89357150
82Abnormality of T cell number (HP:0011839)1.89203817
83Increased serum lactate (HP:0002151)1.89045734
84Nephrogenic diabetes insipidus (HP:0009806)1.88674470
85Male pseudohermaphroditism (HP:0000037)1.87170033
86Abnormal drinking behavior (HP:0030082)1.86525261
87Polydipsia (HP:0001959)1.86525261
88Glossoptosis (HP:0000162)1.86210352
89Symptomatic seizures (HP:0011145)1.85752200
90Brushfield spots (HP:0001088)1.85496062
91Optic nerve hypoplasia (HP:0000609)1.85234443
92Respiratory difficulties (HP:0002880)1.85032817
93Joint swelling (HP:0001386)1.84316882
94Leukodystrophy (HP:0002415)1.83897128
95Congenital primary aphakia (HP:0007707)1.82923511
96IgG deficiency (HP:0004315)1.80600741
97Decreased activity of mitochondrial respiratory chain (HP:0008972)1.80310233
98Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.80310233
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79069997
100Abnormality of methionine metabolism (HP:0010901)1.78772859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK68.97128052
2IRAK16.01341272
3TIE13.52308521
4WEE13.28251347
5MAPK152.69251867
6PNCK2.51397396
7MAP4K22.24158311
8TAOK32.16638312
9SCYL22.04093586
10INSRR1.93113434
11DAPK21.85235307
12CAMKK21.80371978
13MAPKAPK51.79038513
14GRK11.73210430
15MST41.68962088
16MAPKAPK31.66392669
17TESK11.62031486
18WNK41.50925759
19BUB11.46284887
20KIT1.41012242
21VRK11.39804508
22TLK11.35996927
23DYRK31.26054346
24ZAK1.22103197
25CASK1.18563892
26BMPR21.15414464
27PBK1.15092366
28VRK21.13897971
29LATS21.08346084
30ADRBK21.03485496
31PLK41.02594594
32EIF2AK21.00223526
33STK390.96042184
34PTK2B0.84337164
35PLK30.82604405
36EIF2AK10.80103952
37BRSK20.79805888
38MKNK20.78419240
39KDR0.75853483
40NUAK10.74331028
41CDK80.70246113
42MAP3K120.69131409
43FRK0.67777507
44MELK0.64741023
45JAK10.63865122
46OXSR10.63774845
47ACVR1B0.61250961
48EIF2AK30.59500701
49PDK20.59147726
50CLK10.56341752
51NEK10.54216800
52CSF1R0.53472840
53TEC0.52293175
54TXK0.50939836
55MYLK0.50059630
56MAP2K20.48320738
57MAP4K10.47661038
58BMPR1B0.47219012
59CAMK1D0.45880737
60FES0.44822765
61IKBKB0.44727401
62CDK30.43182822
63TAF10.41402385
64PIK3CG0.39917718
65NLK0.39514926
66ADRBK10.39347002
67SYK0.38207879
68ZAP700.37864572
69ROCK10.37295340
70JAK30.33478252
71PLK10.32772269
72TESK20.32660481
73PRKCE0.31764798
74DAPK10.31176550
75IGF1R0.30390095
76PAK60.28823261
77LYN0.28478503
78LCK0.28214071
79BCR0.26949852
80STK40.26661862
81TYK20.25918936
82PRKCG0.25849335
83NME10.25442203
84PKN10.24931988
85CAMKK10.24808980
86PAK10.23050827
87MATK0.21840875
88BRD40.20428110
89RPS6KA50.18868000
90MKNK10.18193897
91TRPM70.17275580
92MAP2K60.17170926
93RPS6KB20.16588345
94UHMK10.15761023
95MAP3K140.15433400
96TGFBR10.15038287
97ITK0.13866929
98MAPKAPK20.13289837
99EGFR0.13277494
100BLK0.12564749

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.00084279
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.63232079
3Allograft rejection_Homo sapiens_hsa053303.30490209
4Autoimmune thyroid disease_Homo sapiens_hsa053203.28567107
5Nitrogen metabolism_Homo sapiens_hsa009103.21516065
6Proteasome_Homo sapiens_hsa030503.20936246
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.10501282
8Antigen processing and presentation_Homo sapiens_hsa046122.90572712
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.76525097
10Graft-versus-host disease_Homo sapiens_hsa053322.41426578
11Protein export_Homo sapiens_hsa030602.20893714
12Oxidative phosphorylation_Homo sapiens_hsa001902.15514789
13Type I diabetes mellitus_Homo sapiens_hsa049402.14664014
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10019306
15Parkinsons disease_Homo sapiens_hsa050121.95984410
16Butanoate metabolism_Homo sapiens_hsa006501.94372750
17Legionellosis_Homo sapiens_hsa051341.93579839
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93152157
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.69353288
20RNA polymerase_Homo sapiens_hsa030201.57416898
21Phototransduction_Homo sapiens_hsa047441.51836867
22One carbon pool by folate_Homo sapiens_hsa006701.41030750
23Fatty acid biosynthesis_Homo sapiens_hsa000611.36806143
24Huntingtons disease_Homo sapiens_hsa050161.31955123
25Peroxisome_Homo sapiens_hsa041461.29315829
26RNA degradation_Homo sapiens_hsa030181.27394240
27Homologous recombination_Homo sapiens_hsa034401.26540054
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25971747
29Measles_Homo sapiens_hsa051621.22851282
30Rheumatoid arthritis_Homo sapiens_hsa053231.22067097
31Spliceosome_Homo sapiens_hsa030401.16888769
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15369294
33Hematopoietic cell lineage_Homo sapiens_hsa046401.07966704
34Alzheimers disease_Homo sapiens_hsa050101.05033510
35Linoleic acid metabolism_Homo sapiens_hsa005911.04989881
36Primary immunodeficiency_Homo sapiens_hsa053401.02900916
37Primary bile acid biosynthesis_Homo sapiens_hsa001200.97310196
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94109041
39Leishmaniasis_Homo sapiens_hsa051400.91198681
40Staphylococcus aureus infection_Homo sapiens_hsa051500.87784625
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85253665
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85142627
43Ether lipid metabolism_Homo sapiens_hsa005650.84216900
44Glycosaminoglycan degradation_Homo sapiens_hsa005310.84133627
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83811829
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82740857
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82336049
48Cardiac muscle contraction_Homo sapiens_hsa042600.82088541
49Influenza A_Homo sapiens_hsa051640.80465668
50Toxoplasmosis_Homo sapiens_hsa051450.80226598
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78453650
52Nicotine addiction_Homo sapiens_hsa050330.76968688
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75359464
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74306433
55Ribosome_Homo sapiens_hsa030100.72911697
56Epstein-Barr virus infection_Homo sapiens_hsa051690.72155169
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.71101068
58African trypanosomiasis_Homo sapiens_hsa051430.70542327
59Non-homologous end-joining_Homo sapiens_hsa034500.70223661
60Basal transcription factors_Homo sapiens_hsa030220.69332553
61Pyrimidine metabolism_Homo sapiens_hsa002400.67621038
62Viral myocarditis_Homo sapiens_hsa054160.66110824
63Purine metabolism_Homo sapiens_hsa002300.58651873
64Regulation of autophagy_Homo sapiens_hsa041400.58098057
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54009510
66RNA transport_Homo sapiens_hsa030130.51689133
67Olfactory transduction_Homo sapiens_hsa047400.50402377
68Morphine addiction_Homo sapiens_hsa050320.48772358
69Taste transduction_Homo sapiens_hsa047420.48676311
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48639820
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48241114
72GABAergic synapse_Homo sapiens_hsa047270.47361404
73Arachidonic acid metabolism_Homo sapiens_hsa005900.47088634
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.46138289
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.45106749
76Mineral absorption_Homo sapiens_hsa049780.44550244
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44514580
78Estrogen signaling pathway_Homo sapiens_hsa049150.43471752
79Systemic lupus erythematosus_Homo sapiens_hsa053220.43345520
80Fatty acid metabolism_Homo sapiens_hsa012120.41649959
81Tryptophan metabolism_Homo sapiens_hsa003800.39795465
82Ovarian steroidogenesis_Homo sapiens_hsa049130.39500832
83Herpes simplex infection_Homo sapiens_hsa051680.38074755
84Chemical carcinogenesis_Homo sapiens_hsa052040.37550748
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35557480
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34330155
87Notch signaling pathway_Homo sapiens_hsa043300.33912355
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32458730
89Metabolic pathways_Homo sapiens_hsa011000.30665145
90Nucleotide excision repair_Homo sapiens_hsa034200.29681882
91Propanoate metabolism_Homo sapiens_hsa006400.28203425
92T cell receptor signaling pathway_Homo sapiens_hsa046600.27912391
93p53 signaling pathway_Homo sapiens_hsa041150.27267256
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26842944
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26539529
96Arginine biosynthesis_Homo sapiens_hsa002200.25573615
97Renin-angiotensin system_Homo sapiens_hsa046140.24759952
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23261205
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21709210
100Prion diseases_Homo sapiens_hsa050200.21511998

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