PDDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.80223084
2ribosomal small subunit assembly (GO:0000028)5.33039436
3positive regulation of CREB transcription factor activity (GO:0032793)5.28762087
4L-fucose catabolic process (GO:0042355)4.71845005
5fucose catabolic process (GO:0019317)4.71845005
6L-fucose metabolic process (GO:0042354)4.71845005
7DNA deamination (GO:0045006)4.66253426
8response to pheromone (GO:0019236)4.63258063
9positive regulation of fatty acid beta-oxidation (GO:0032000)4.00236004
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.97970227
11protein import into peroxisome matrix (GO:0016558)3.93427136
12signal peptide processing (GO:0006465)3.88429332
13negative regulation of telomere maintenance (GO:0032205)3.81823401
14negative regulation of synaptic transmission, GABAergic (GO:0032229)3.77782643
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.71100444
16regulation of hippo signaling (GO:0035330)3.65997470
17cotranslational protein targeting to membrane (GO:0006613)3.64939874
18regulation of mitochondrial translation (GO:0070129)3.63233545
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.61474111
20termination of RNA polymerase III transcription (GO:0006386)3.61474111
21protein targeting to ER (GO:0045047)3.56894844
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.55083907
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.55083907
24regulation of histone phosphorylation (GO:0033127)3.52792247
25regulation of nuclear cell cycle DNA replication (GO:0033262)3.52139329
26nephron tubule morphogenesis (GO:0072078)3.51925838
27nephron epithelium morphogenesis (GO:0072088)3.51925838
28urinary tract smooth muscle contraction (GO:0014848)3.50862888
29proteasome assembly (GO:0043248)3.48333374
30positive regulation of fatty acid oxidation (GO:0046321)3.47615914
31L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.44641235
32protein localization to endoplasmic reticulum (GO:0070972)3.42820985
33kynurenine metabolic process (GO:0070189)3.42154713
34metallo-sulfur cluster assembly (GO:0031163)3.41624586
35iron-sulfur cluster assembly (GO:0016226)3.41624586
36fucosylation (GO:0036065)3.41584631
37viral transcription (GO:0019083)3.35779354
38negative regulation of reactive oxygen species metabolic process (GO:2000378)3.34711191
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.32479315
40cytochrome complex assembly (GO:0017004)3.31644502
41respiratory chain complex IV assembly (GO:0008535)3.29654987
42protein complex biogenesis (GO:0070271)3.25118223
43regulation of respiratory system process (GO:0044065)3.23003835
44deoxyribose phosphate biosynthetic process (GO:0046385)3.18636263
452-deoxyribonucleotide biosynthetic process (GO:0009265)3.18636263
46positive regulation of triglyceride biosynthetic process (GO:0010867)3.18538470
47sequestering of actin monomers (GO:0042989)3.17347944
48tRNA methylation (GO:0030488)3.14056259
49indole-containing compound catabolic process (GO:0042436)3.12680247
50indolalkylamine catabolic process (GO:0046218)3.12680247
51tryptophan catabolic process (GO:0006569)3.12680247
52histone-serine phosphorylation (GO:0035404)3.11951979
53cellular response to exogenous dsRNA (GO:0071360)3.11338489
54telomere maintenance via semi-conservative replication (GO:0032201)3.10637642
55viral protein processing (GO:0019082)3.09610300
56translational termination (GO:0006415)3.08802987
57primary amino compound metabolic process (GO:1901160)3.06095616
58pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.05657499
597-methylguanosine mRNA capping (GO:0006370)3.05517072
60negative regulation of translation, ncRNA-mediated (GO:0040033)3.04601018
61regulation of translation, ncRNA-mediated (GO:0045974)3.04601018
62negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.04601018
63opioid receptor signaling pathway (GO:0038003)3.02988141
64RNA capping (GO:0036260)3.02766019
657-methylguanosine RNA capping (GO:0009452)3.02766019
66nucleoside diphosphate catabolic process (GO:0009134)3.02733627
67postsynaptic membrane organization (GO:0001941)3.02234836
68mannosylation (GO:0097502)3.02185978
69cellular ketone body metabolic process (GO:0046950)3.02060534
70positive regulation of sodium ion transmembrane transport (GO:1902307)2.97758076
71rRNA modification (GO:0000154)2.96701056
72membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.93795828
73deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.93761589
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.91967951
75synaptic vesicle docking involved in exocytosis (GO:0016081)2.91594610
76sulfate transport (GO:0008272)2.90711396
77response to interferon-beta (GO:0035456)2.90098824
78regulation of hydrogen peroxide metabolic process (GO:0010310)2.89487283
79protein deneddylation (GO:0000338)2.89233380
80positive regulation of protein kinase C signaling (GO:0090037)2.88800029
81regulation of triglyceride biosynthetic process (GO:0010866)2.87951753
82mitochondrial respiratory chain complex assembly (GO:0033108)2.87502068
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87134790
84NAD biosynthetic process (GO:0009435)2.86960371
85translational elongation (GO:0006414)2.86657269
86platelet dense granule organization (GO:0060155)2.86650925
87positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.85993699
88purine deoxyribonucleotide catabolic process (GO:0009155)2.85629255
89positive regulation of histone acetylation (GO:0035066)2.85555414
90cellular response to ATP (GO:0071318)2.85549188
91peristalsis (GO:0030432)2.85344682
92dermatan sulfate metabolic process (GO:0030205)2.84707939
93ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.84159099
94gamma-aminobutyric acid transport (GO:0015812)2.83491104
95regulation of posttranscriptional gene silencing (GO:0060147)2.83453680
96regulation of gene silencing by miRNA (GO:0060964)2.83453680
97regulation of gene silencing by RNA (GO:0060966)2.83453680
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83235617
99mitochondrial respiratory chain complex I assembly (GO:0032981)2.83235617
100NADH dehydrogenase complex assembly (GO:0010257)2.83235617
101endosome to pigment granule transport (GO:0043485)2.83127811
102endosome to melanosome transport (GO:0035646)2.83127811
103cullin deneddylation (GO:0010388)2.82730877
104ribosomal small subunit biogenesis (GO:0042274)2.82300701
105viral mRNA export from host cell nucleus (GO:0046784)2.81807330
106regulation of fatty acid beta-oxidation (GO:0031998)2.81301322
107GMP metabolic process (GO:0046037)2.81086787
108negative regulation of macroautophagy (GO:0016242)2.80514577
109rRNA methylation (GO:0031167)2.79546850
110translation (GO:0006412)2.79250826
111basic amino acid transport (GO:0015802)2.79181477
112meiotic chromosome segregation (GO:0045132)2.78319652
113tRNA modification (GO:0006400)2.76888913
114antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.76844295
115tRNA processing (GO:0008033)2.76721836
116kidney morphogenesis (GO:0060993)2.76322413
117regulation of short-term neuronal synaptic plasticity (GO:0048172)2.76257374
118dermatan sulfate biosynthetic process (GO:0030208)2.76244564
119negative regulation of leukocyte chemotaxis (GO:0002689)2.73876251
120deoxyribonucleotide catabolic process (GO:0009264)2.73560481
121DNA damage response, detection of DNA damage (GO:0042769)2.72517105
122telomere maintenance via recombination (GO:0000722)2.71621587
123peptidyl-histidine modification (GO:0018202)2.70900501
124neuronal action potential (GO:0019228)2.70842738
125macroautophagy (GO:0016236)2.70290659
126transcription-coupled nucleotide-excision repair (GO:0006283)2.69995033
127response to misfolded protein (GO:0051788)2.69716752
128negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69541429
129ribosomal large subunit biogenesis (GO:0042273)2.67726742
130lymphoid progenitor cell differentiation (GO:0002320)2.67581000
131polyketide metabolic process (GO:0030638)2.67215063
132doxorubicin metabolic process (GO:0044598)2.67215063
133daunorubicin metabolic process (GO:0044597)2.67215063
134DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.66840946
135serotonin metabolic process (GO:0042428)2.66774005
136signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.65715451
137signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.65715451
138signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.65715451
139viral life cycle (GO:0019058)2.65444302
140cell migration in hindbrain (GO:0021535)2.65182188
141maturation of SSU-rRNA (GO:0030490)2.64187398
142central nervous system myelination (GO:0022010)2.64051749
143axon ensheathment in central nervous system (GO:0032291)2.64051749
144pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.62429316
145indole-containing compound metabolic process (GO:0042430)2.62366442
146signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.61685198
147intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.61685198
148indolalkylamine metabolic process (GO:0006586)2.61495645
149cornea development in camera-type eye (GO:0061303)2.61393770
150DNA damage induced protein phosphorylation (GO:0006975)2.60809157
151cellular response to interferon-beta (GO:0035458)2.59963939
152positive regulation of protein acetylation (GO:1901985)2.59515229
153positive regulation of peptidyl-lysine acetylation (GO:2000758)2.59515229
154GDP-mannose metabolic process (GO:0019673)2.59373011
155nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.59371431
156regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.58730811
157atrial cardiac muscle cell action potential (GO:0086014)2.58725991
158interleukin-1-mediated signaling pathway (GO:0070498)2.58520427
159neurotransmitter metabolic process (GO:0042133)2.58249643
160tryptophan metabolic process (GO:0006568)2.58130800
1612-deoxyribonucleotide metabolic process (GO:0009394)2.57593555
162membrane repolarization during action potential (GO:0086011)2.57591750
163misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.57118080
164membrane depolarization during action potential (GO:0086010)2.56975277
165amino acid salvage (GO:0043102)2.56910532
166L-methionine salvage (GO:0071267)2.56910532
167L-methionine biosynthetic process (GO:0071265)2.56910532
168guanosine-containing compound biosynthetic process (GO:1901070)2.56462689
169ketone body metabolic process (GO:1902224)2.56274311
170poly(A)+ mRNA export from nucleus (GO:0016973)2.56117161
171cardiovascular system development (GO:0072358)2.55988661
172regulation of respiratory gaseous exchange (GO:0043576)2.55786257
173pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.55524679
174alanine transport (GO:0032328)2.55123882
175pseudouridine synthesis (GO:0001522)2.53959071
176deoxyribonucleotide biosynthetic process (GO:0009263)2.53862171
177positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.53854977
178DNA catabolic process, exonucleolytic (GO:0000738)2.53435153
179epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53000330
180DNA strand elongation involved in DNA replication (GO:0006271)2.51593866
181DNA ligation (GO:0006266)2.51250673
182DNA strand elongation (GO:0022616)2.50480507
183deoxyribose phosphate catabolic process (GO:0046386)2.50043118
184cellular response to cholesterol (GO:0071397)2.49806551
185negative regulation of sodium ion transport (GO:0010766)2.49759561
186exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49584332
187sulfate transmembrane transport (GO:1902358)2.49171027
188nonmotile primary cilium assembly (GO:0035058)2.48909481
189organelle disassembly (GO:1903008)2.47960745
190GPI anchor biosynthetic process (GO:0006506)2.47885556
191cellular protein complex disassembly (GO:0043624)2.47528689
192signal transduction involved in cell cycle checkpoint (GO:0072395)2.47178326
193signal transduction involved in DNA integrity checkpoint (GO:0072401)2.47124988
194regulation of mesoderm development (GO:2000380)2.46295477
195transmission of nerve impulse (GO:0019226)2.46077457
196positive regulation of histone deacetylation (GO:0031065)2.44049224
197snRNA transcription (GO:0009301)2.43548084
198positive regulation of guanylate cyclase activity (GO:0031284)2.42391993
199detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.42309457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.43987168
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.35005294
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.11890028
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.00467818
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.84614921
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66368402
7ZNF274_21170338_ChIP-Seq_K562_Hela3.63761004
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.49535258
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.45984436
10E2F7_22180533_ChIP-Seq_HELA_Human3.02117487
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94262678
12DROSHA_22980978_ChIP-Seq_HELA_Human2.89935221
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.86266546
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.83911182
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.81321005
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.79330963
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.78496234
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.72794392
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.72391930
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.68046627
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.67686151
22VDR_23849224_ChIP-Seq_CD4+_Human2.63086900
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.56623125
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.55313076
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.48796212
26* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45234498
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.40973055
28FOXP3_21729870_ChIP-Seq_TREG_Human2.38179905
29CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35767043
30HOXB4_20404135_ChIP-ChIP_EML_Mouse2.32961104
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.29562332
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.29538776
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26833889
34EZH2_27294783_Chip-Seq_ESCs_Mouse2.24956143
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24087229
36REST_21632747_ChIP-Seq_MESCs_Mouse2.19139194
37SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13086081
38ELK1_19687146_ChIP-ChIP_HELA_Human2.08782355
39YY1_21170310_ChIP-Seq_MESCs_Mouse2.08367168
40MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08152863
41EED_16625203_ChIP-ChIP_MESCs_Mouse2.07217025
42ERG_20887958_ChIP-Seq_HPC-7_Mouse2.05725910
43JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00701809
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99705972
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97687087
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96524638
47* P68_20966046_ChIP-Seq_HELA_Human1.96243166
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.90337310
49XRN2_22483619_ChIP-Seq_HELA_Human1.88704736
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.88278896
51ERA_21632823_ChIP-Seq_H3396_Human1.87515489
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87259889
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.85154745
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84516560
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.83486916
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.80602395
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.78497047
58CTCF_27219007_Chip-Seq_Bcells_Human1.78452094
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.78412029
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.77103136
61DCP1A_22483619_ChIP-Seq_HELA_Human1.77046572
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76454521
63AR_21572438_ChIP-Seq_LNCaP_Human1.74816516
64GABP_19822575_ChIP-Seq_HepG2_Human1.74140440
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71051103
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.70034601
67E2F1_20622854_ChIP-Seq_HELA_Human1.69836871
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69693208
69CIITA_25753668_ChIP-Seq_RAJI_Human1.69186228
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64310920
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64275404
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64054153
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.63152170
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63084179
75TTF2_22483619_ChIP-Seq_HELA_Human1.62507910
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61859562
77* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61022461
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60078393
79* PHF8_20622854_ChIP-Seq_HELA_Human1.59974846
80SPI1_23547873_ChIP-Seq_NB4_Human1.59405203
81* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.58940007
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.56307096
83LXR_22292898_ChIP-Seq_THP-1_Human1.54698026
84SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54466965
85MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54466306
86TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.54388082
87RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53705211
88EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53705211
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53663549
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52856749
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50904038
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50781351
93NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48433773
94* BCL6_27268052_Chip-Seq_Bcells_Human1.47807756
95* OCT4_19829295_ChIP-Seq_ESCs_Human1.47706530
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46784599
97CTCF_20526341_ChIP-Seq_ESCs_Human1.45888305
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.45715084
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.45332591
100IRF1_19129219_ChIP-ChIP_H3396_Human1.44378700
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44308254
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43383304
103BCOR_27268052_Chip-Seq_Bcells_Human1.43047974
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42682385
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40684583
106MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40346913
107TAF2_19829295_ChIP-Seq_ESCs_Human1.39291389
108TET1_21451524_ChIP-Seq_MESCs_Mouse1.37501455
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37367985
110STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35851372
111TP53_22127205_ChIP-Seq_IMR90_Human1.35496374
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35122484
113* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34820357
114E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33599596
115VDR_22108803_ChIP-Seq_LS180_Human1.33450030
116SMC4_20622854_ChIP-Seq_HELA_Human1.31946636
117SCL_19346495_ChIP-Seq_HPC-7_Human1.31587800
118* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30684932
119TP63_22573176_ChIP-Seq_HFKS_Human1.29988325
120* YY1_22570637_ChIP-Seq_MALME-3M_Human1.29330008
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27544288
122ELK1_22589737_ChIP-Seq_MCF10A_Human1.26996072
123TP63_19390658_ChIP-ChIP_HaCaT_Human1.26726942
124P53_21459846_ChIP-Seq_SAOS-2_Human1.25641219
125RAC3_21632823_ChIP-Seq_H3396_Human1.25090184
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24832979
127SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23948872
128GATA3_21878914_ChIP-Seq_MCF-7_Human1.22505482
129MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.22261505
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22128743
131EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21775512
132SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20725474
133CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20461497
134* TP53_23651856_ChIP-Seq_MEFs_Mouse1.20090285
135LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19535088
136TP53_20018659_ChIP-ChIP_R1E_Mouse1.19457233
137* OCT4_20526341_ChIP-Seq_ESCs_Human1.19330836
138* SA1_27219007_Chip-Seq_Bcells_Human1.18887925
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18677645
140TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17137628
141RARB_24833708_ChIP-Seq_LIVER_Mouse1.15831149
142MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15756868
143ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15582801
144ELF1_20517297_ChIP-Seq_JURKAT_Human1.14629194
145P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.11961303
146RING1B_27294783_Chip-Seq_ESCs_Mouse1.11728816
147ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10054203
148BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09533322
149KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09004483
150ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08600563
151SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07721630
152P300_27268052_Chip-Seq_Bcells_Human1.07366563
153NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07285107
154SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06637725
155CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05803861
156VDR_21846776_ChIP-Seq_THP-1_Human1.05732944
157TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05465990
158GBX2_23144817_ChIP-Seq_PC3_Human1.05133798
159* SMAD4_21741376_ChIP-Seq_ESCs_Human1.04991057
160NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.04824374
161SA1_27219007_Chip-Seq_ERYTHROID_Human1.04639770
162KDM2B_26808549_Chip-Seq_K562_Human1.03841463
163GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02925556
164RARA_24833708_ChIP-Seq_LIVER_Mouse1.02724261
165HOXB7_26014856_ChIP-Seq_BT474_Human1.02635410
166MYC_18940864_ChIP-ChIP_HL60_Human1.02453998
167CREB1_26743006_Chip-Seq_LNCaP_Human1.02399069
168BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01776753
169* KLF4_19829295_ChIP-Seq_ESCs_Human1.01716876
170RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01655653
171RARB_27405468_Chip-Seq_BRAIN_Mouse1.00672519
172NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00529235
173PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00424264
174MYC_19829295_ChIP-Seq_ESCs_Human0.99789533
175BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98798565
176RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97868340
177TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97628541
178FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96582614
179TFEB_21752829_ChIP-Seq_HELA_Human0.96503806
180PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96079075
181CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92917970
182MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92548509
183POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92526511
184GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91627808
185KDM5A_27292631_Chip-Seq_BREAST_Human0.89182918
186* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88306438
187PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87824528
188FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.83709403
189MYB_26560356_Chip-Seq_TH2_Human0.75064010
190RUNX1_22412390_ChIP-Seq_EML_Mouse0.74354072
191* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.73849106
192EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.73833966
193SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.73502155
194PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.73225803
195KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.73116647
196SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70339357

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity3.73609246
2MP0006292_abnormal_olfactory_placode3.26137706
3MP0005379_endocrine/exocrine_gland_phen3.13143351
4MP0004043_abnormal_pH_regulation3.12410183
5MP0003646_muscle_fatigue3.02285055
6MP0004130_abnormal_muscle_cell2.88344384
7MP0004147_increased_porphyrin_level2.82394406
8MP0008058_abnormal_DNA_repair2.79012472
9MP0001835_abnormal_antigen_presentation2.47653097
10MP0009046_muscle_twitch2.46990778
11MP0005075_abnormal_melanosome_morpholog2.40609472
12MP0003283_abnormal_digestive_organ2.40058748
13MP0009745_abnormal_behavioral_response2.38970233
14MP0002396_abnormal_hematopoietic_system2.34046623
15MP0001968_abnormal_touch/_nociception2.33982656
16MP0002148_abnormal_hypersensitivity_rea2.27535709
17MP0005671_abnormal_response_to2.27530439
18MP0004133_heterotaxia2.23890270
19MP0002638_abnormal_pupillary_reflex2.20936352
20MP0002653_abnormal_ependyma_morphology2.20569951
21MP0003763_abnormal_thymus_physiology2.19184458
22MP0005167_abnormal_blood-brain_barrier2.18470586
23MP0003693_abnormal_embryo_hatching2.16793144
24MP0003878_abnormal_ear_physiology2.12737518
25MP0005377_hearing/vestibular/ear_phenot2.12737518
26MP0002064_seizures2.12716852
27MP0002163_abnormal_gland_morphology2.12413608
28MP0003195_calcinosis2.06948487
29MP0004885_abnormal_endolymph2.02088341
30MP0002063_abnormal_learning/memory/cond1.96402115
31MP0001188_hyperpigmentation1.96311679
32MP0009785_altered_susceptibility_to1.93778710
33MP0005551_abnormal_eye_electrophysiolog1.92416040
34MP0010386_abnormal_urinary_bladder1.92266753
35MP0000685_abnormal_immune_system1.90319435
36MP0008872_abnormal_physiological_respon1.88617555
37MP0008007_abnormal_cellular_replicative1.85992003
38MP0001970_abnormal_pain_threshold1.84946278
39MP0001485_abnormal_pinna_reflex1.84882906
40MP0008875_abnormal_xenobiotic_pharmacok1.83550501
41MP0003635_abnormal_synaptic_transmissio1.83110102
42MP0001502_abnormal_circadian_rhythm1.82976198
43MP0002733_abnormal_thermal_nociception1.80991208
44MP0002572_abnormal_emotion/affect_behav1.79427468
45MP0009379_abnormal_foot_pigmentation1.76808630
46MP0008057_abnormal_DNA_replication1.75209715
47MP0002132_abnormal_respiratory_system1.74752728
48MP0003183_abnormal_peptide_metabolism1.71223963
49MP0001790_abnormal_immune_system1.69736948
50MP0005387_immune_system_phenotype1.69736948
51MP0005174_abnormal_tail_pigmentation1.69713407
52MP0003136_yellow_coat_color1.69342761
53MP0000015_abnormal_ear_pigmentation1.68489112
54MP0002009_preneoplasia1.67255470
55MP0010094_abnormal_chromosome_stability1.63673287
56MP0002272_abnormal_nervous_system1.63345926
57MP0004742_abnormal_vestibular_system1.62785119
58MP0001486_abnormal_startle_reflex1.62609847
59MP0002876_abnormal_thyroid_physiology1.61711470
60MP0000372_irregular_coat_pigmentation1.60260246
61MP0002095_abnormal_skin_pigmentation1.57722361
62MP0000566_synostosis1.57235740
63MP0005025_abnormal_response_to1.55187378
64MP0002277_abnormal_respiratory_mucosa1.55097641
65MP0002420_abnormal_adaptive_immunity1.54821149
66MP0005000_abnormal_immune_tolerance1.54208818
67MP0001800_abnormal_humoral_immune1.53294246
68MP0001819_abnormal_immune_cell1.53042282
69MP0001501_abnormal_sleep_pattern1.52701862
70MP0002723_abnormal_immune_serum1.52224639
71MP0002557_abnormal_social/conspecific_i1.49553821
72MP0004859_abnormal_synaptic_plasticity1.47971986
73MP0005423_abnormal_somatic_nervous1.46966950
74MP0004142_abnormal_muscle_tone1.46661847
75MP0002398_abnormal_bone_marrow1.46288992
76MP0009384_cardiac_valve_regurgitation1.43785414
77MP0005645_abnormal_hypothalamus_physiol1.43504373
78MP0002452_abnormal_antigen_presenting1.41397276
79MP0000778_abnormal_nervous_system1.41193887
80MP0002751_abnormal_autonomic_nervous1.41106442
81MP0008789_abnormal_olfactory_epithelium1.40324433
82MP0008877_abnormal_DNA_methylation1.37312755
83MP0005386_behavior/neurological_phenoty1.37229603
84MP0004924_abnormal_behavior1.37229603
85MP0008260_abnormal_autophagy1.37117652
86MP0009333_abnormal_splenocyte_physiolog1.36856733
87MP0003436_decreased_susceptibility_to1.36145448
88MP0000490_abnormal_crypts_of1.35963076
89MP0000716_abnormal_immune_system1.35023591
90MP0003137_abnormal_impulse_conducting1.34826927
91MP0002693_abnormal_pancreas_physiology1.34548911
92MP0004858_abnormal_nervous_system1.34189931
93MP0000569_abnormal_digit_pigmentation1.34003539
94MP0002734_abnormal_mechanical_nocicepti1.33416470
95MP0002067_abnormal_sensory_capabilities1.32655296
96MP0003724_increased_susceptibility_to1.32502917
97MP0000538_abnormal_urinary_bladder1.31142573
98MP0010030_abnormal_orbit_morphology1.29401804
99MP0002419_abnormal_innate_immunity1.28563229
100MP0000681_abnormal_thyroid_gland1.27351336
101MP0008961_abnormal_basal_metabolism1.24649997
102MP0009840_abnormal_foam_cell1.24516069
103MP0001905_abnormal_dopamine_level1.24158854
104MP0000427_abnormal_hair_cycle1.22589638
105MP0003866_abnormal_defecation1.21908523
106MP0003077_abnormal_cell_cycle1.20632718
107MP0005084_abnormal_gallbladder_morpholo1.20275104
108MP0000689_abnormal_spleen_morphology1.20002474
109MP0002429_abnormal_blood_cell1.19368887
110MP0005310_abnormal_salivary_gland1.18539272
111MP0003787_abnormal_imprinting1.18368461
112MP0005448_abnormal_energy_balance1.18129927
113MP0000026_abnormal_inner_ear1.17569717
114MP0003119_abnormal_digestive_system1.17302284
115MP0003122_maternal_imprinting1.17296596
116MP0002249_abnormal_larynx_morphology1.15671308
117MP0005464_abnormal_platelet_physiology1.14019685
118MP0000678_abnormal_parathyroid_gland1.13734817
119MP0002722_abnormal_immune_system1.11250873
120MP0002938_white_spotting1.09331355
121MP0001764_abnormal_homeostasis1.09186427
122MP0001873_stomach_inflammation1.09108408
123MP0003786_premature_aging1.06959065
124MP0006276_abnormal_autonomic_nervous1.06752026
125MP0003186_abnormal_redox_activity1.05493259
126MP0001664_abnormal_digestion1.05024358
127MP0005360_urolithiasis1.04765021
128MP0001853_heart_inflammation1.04114375
129MP0000230_abnormal_systemic_arterial1.03890312
130MP0002166_altered_tumor_susceptibility1.01867925
131MP0002405_respiratory_system_inflammati1.00196918
132MP0000703_abnormal_thymus_morphology0.99291622
133MP0000955_abnormal_spinal_cord0.98968530
134MP0000631_abnormal_neuroendocrine_gland0.98032947
135MP0002882_abnormal_neuron_morphology0.97141624
136MP0004957_abnormal_blastocyst_morpholog0.96893026
137MP0001663_abnormal_digestive_system0.96590048
138MP0002160_abnormal_reproductive_system0.96350082
139MP0004145_abnormal_muscle_electrophysio0.95637720
140MP0005503_abnormal_tendon_morphology0.95485121
141MP0008775_abnormal_heart_ventricle0.95103070
142MP0006072_abnormal_retinal_apoptosis0.94950297
143MP0001348_abnormal_lacrimal_gland0.94577383
144MP0004381_abnormal_hair_follicle0.93956141
145MP0005499_abnormal_olfactory_system0.92957189
146MP0005394_taste/olfaction_phenotype0.92957189
147MP0005195_abnormal_posterior_eye0.92637726
148MP0010329_abnormal_lipoprotein_level0.91241646
149MP0001845_abnormal_inflammatory_respons0.91116890
150MP0004808_abnormal_hematopoietic_stem0.90495463
151MP0003011_delayed_dark_adaptation0.90166951
152MP0002184_abnormal_innervation0.90151883
153MP0010155_abnormal_intestine_physiology0.89888262
154MP0004782_abnormal_surfactant_physiolog0.89470405
155MP0001963_abnormal_hearing_physiology0.89459638
156MP0005409_darkened_coat_color0.89024737
157MP0005595_abnormal_vascular_smooth0.87979988
158MP0000613_abnormal_salivary_gland0.87168775
159MP0005253_abnormal_eye_physiology0.86415107
160MP0001944_abnormal_pancreas_morphology0.86222783
161MP0005646_abnormal_pituitary_gland0.86131564
162MP0002752_abnormal_somatic_nervous0.85866040
163MP0000470_abnormal_stomach_morphology0.85847062
164MP0002152_abnormal_brain_morphology0.85546904
165MP0008932_abnormal_embryonic_tissue0.85308209
166MP0002736_abnormal_nociception_after0.84682094
167MP0002735_abnormal_chemical_nociception0.84223051
168MP0000465_gastrointestinal_hemorrhage0.84033714
169MP0001529_abnormal_vocalization0.84013549
170MP0003329_amyloid_beta_deposits0.83493241
171MP0009697_abnormal_copulation0.82160044
172MP0005408_hypopigmentation0.81637385
173MP0003879_abnormal_hair_cell0.81405425
174MP0000049_abnormal_middle_ear0.81059479
175MP0005389_reproductive_system_phenotype0.80714874
176MP0002102_abnormal_ear_morphology0.80642113
177MP0000383_abnormal_hair_follicle0.80318997
178MP0002933_joint_inflammation0.79851830
179MP0002006_tumorigenesis0.79051231
180MP0002066_abnormal_motor_capabilities/c0.78624652
181MP0002928_abnormal_bile_duct0.77838779
182MP0002234_abnormal_pharynx_morphology0.75378862
183MP0005171_absent_coat_pigmentation0.75055681
184MP0005381_digestive/alimentary_phenotyp0.74860629

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.06976909
2Breast hypoplasia (HP:0003187)4.69516868
3Hypothermia (HP:0002045)4.21949001
4Type I transferrin isoform profile (HP:0003642)3.98612687
5Patellar aplasia (HP:0006443)3.95820332
6Aplastic anemia (HP:0001915)3.79972843
7Abnormality of alanine metabolism (HP:0010916)3.77132850
8Hyperalaninemia (HP:0003348)3.77132850
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.77132850
10Type II lissencephaly (HP:0007260)3.75586558
11Aplasia/Hypoplasia of the patella (HP:0006498)3.73069313
12Protruding tongue (HP:0010808)3.66709317
13Hyperventilation (HP:0002883)3.66545041
14Large for gestational age (HP:0001520)3.66324451
15Clumsiness (HP:0002312)3.54979397
16Genetic anticipation (HP:0003743)3.50456707
17Congenital stationary night blindness (HP:0007642)3.43939259
18Nephronophthisis (HP:0000090)3.05343947
19Mesangial abnormality (HP:0001966)2.99493189
20Abnormal number of erythroid precursors (HP:0012131)2.95710948
21Acute necrotizing encephalopathy (HP:0006965)2.92242816
22Abnormal protein glycosylation (HP:0012346)2.90491319
23Abnormal glycosylation (HP:0012345)2.90491319
24Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.90491319
25Abnormal protein N-linked glycosylation (HP:0012347)2.90491319
26Increased neuronal autofluorescent lipopigment (HP:0002074)2.88119601
27Abnormality of cells of the erythroid lineage (HP:0012130)2.87239010
28Bronchomalacia (HP:0002780)2.82754888
29Attenuation of retinal blood vessels (HP:0007843)2.82746210
30Thrombocytosis (HP:0001894)2.81632309
31Partial agenesis of the corpus callosum (HP:0001338)2.81004105
32Inability to walk (HP:0002540)2.76332011
33Cystic liver disease (HP:0006706)2.76327137
34Reticulocytopenia (HP:0001896)2.73557310
35Concave nail (HP:0001598)2.71405059
36Severe muscular hypotonia (HP:0006829)2.69131403
37Decreased activity of mitochondrial respiratory chain (HP:0008972)2.68790624
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.68790624
39Hepatocellular necrosis (HP:0001404)2.68299617
40Hepatic necrosis (HP:0002605)2.67731762
41Progressive cerebellar ataxia (HP:0002073)2.67276934
42Mitochondrial inheritance (HP:0001427)2.67095156
43True hermaphroditism (HP:0010459)2.62471511
44Recurrent abscess formation (HP:0002722)2.61878560
45Pancreatic fibrosis (HP:0100732)2.59302596
46Abnormal mitochondria in muscle tissue (HP:0008316)2.57017263
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.56836722
48Tubular atrophy (HP:0000092)2.56619721
49IgM deficiency (HP:0002850)2.55279007
50Cerebellar dysplasia (HP:0007033)2.54335016
51Abnormality of the renal medulla (HP:0100957)2.53435740
52Intestinal atresia (HP:0011100)2.53293344
53Reduced antithrombin III activity (HP:0001976)2.52256847
54Pancreatic cysts (HP:0001737)2.52012676
55Abnormality of the anterior horn cell (HP:0006802)2.51989674
56Degeneration of anterior horn cells (HP:0002398)2.51989674
57Microvesicular hepatic steatosis (HP:0001414)2.51297429
58Slender long bone (HP:0003100)2.50865854
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.50271118
60Decreased circulating renin level (HP:0003351)2.49522561
61Lissencephaly (HP:0001339)2.47417528
62Pendular nystagmus (HP:0012043)2.38571081
63Global brain atrophy (HP:0002283)2.35484646
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.35407999
65Increased CSF lactate (HP:0002490)2.35352472
66Recurrent bacterial skin infections (HP:0005406)2.33065229
67Elevated erythrocyte sedimentation rate (HP:0003565)2.32133134
68Abnormality of the pons (HP:0007361)2.30639338
69Generalized aminoaciduria (HP:0002909)2.30505537
70Chorioretinal atrophy (HP:0000533)2.28100206
71Optic nerve coloboma (HP:0000588)2.26952953
72Broad metatarsal (HP:0001783)2.25382627
733-Methylglutaconic aciduria (HP:0003535)2.24820892
74Vacuolated lymphocytes (HP:0001922)2.24593218
75Renovascular hypertension (HP:0100817)2.24533780
76Progressive macrocephaly (HP:0004481)2.24173164
77Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.21570177
7811 pairs of ribs (HP:0000878)2.20305003
79Increased cerebral lipofuscin (HP:0011813)2.19874941
80Chromsome breakage (HP:0040012)2.17789795
81Petechiae (HP:0000967)2.17294740
82Hyperacusis (HP:0010780)2.15050817
83Severe visual impairment (HP:0001141)2.14332235
84Myositis (HP:0100614)2.13624273
85Furrowed tongue (HP:0000221)2.12543194
86Tachypnea (HP:0002789)2.12225692
87Spastic tetraparesis (HP:0001285)2.10683599
88Hypoplasia of the pons (HP:0012110)2.10580567
89Abnormality of the renal cortex (HP:0011035)2.09967860
90Median cleft lip (HP:0000161)2.08502185
91Medial flaring of the eyebrow (HP:0010747)2.07918088
92Bone marrow hypocellularity (HP:0005528)2.07114289
93Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06544118
94Abnormal rod and cone electroretinograms (HP:0008323)2.05612827
95Tracheomalacia (HP:0002779)2.04038248
96Progressive inability to walk (HP:0002505)2.03990635
97Abnormal delayed hypersensitivity skin test (HP:0002963)2.03130061
98Increased serum lactate (HP:0002151)2.02925347
99Sclerocornea (HP:0000647)2.02642265
100Acute encephalopathy (HP:0006846)2.02267365
101Neutropenia (HP:0001875)2.01815822
102Broad-based gait (HP:0002136)2.00496454
103Impaired smooth pursuit (HP:0007772)2.00230046
104Chronic hepatic failure (HP:0100626)1.99370378
105Hypoplastic ischia (HP:0003175)1.98943770
106Abnormal hair whorl (HP:0010721)1.98503027
107Macroglossia (HP:0000158)1.97321665
108Nephrogenic diabetes insipidus (HP:0009806)1.96932446
109Polydipsia (HP:0001959)1.95532356
110Abnormal drinking behavior (HP:0030082)1.95532356
111Conical tooth (HP:0000698)1.95532326
112Increased IgM level (HP:0003496)1.95261452
113Pallor (HP:0000980)1.94359323
114Flat cornea (HP:0007720)1.94143556
115Osteomalacia (HP:0002749)1.93519245
116Acute lymphatic leukemia (HP:0006721)1.93332610
117Abnormality of binocular vision (HP:0011514)1.92113807
118Diplopia (HP:0000651)1.92113807
119Lymphoma (HP:0002665)1.92073406
120Abnormality of the vertebral endplates (HP:0005106)1.92034432
121Poor head control (HP:0002421)1.91170751
122Microretrognathia (HP:0000308)1.91036702
123Elfin facies (HP:0004428)1.90817060
124Aplasia/hypoplasia of the uterus (HP:0008684)1.90241141
125Rectal prolapse (HP:0002035)1.90145637
126Pancytopenia (HP:0001876)1.89171109
127Congenital, generalized hypertrichosis (HP:0004540)1.88962499
128Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88563338
129Renal cortical cysts (HP:0000803)1.88281643
130Panhypogammaglobulinemia (HP:0003139)1.87228465
131Bulbous nose (HP:0000414)1.86950600
132Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86950027
133Premature graying of hair (HP:0002216)1.86430737
134Aplasia/Hypoplasia of the fovea (HP:0008060)1.85891614
135Hypoplasia of the fovea (HP:0007750)1.85891614
136Prolonged QT interval (HP:0001657)1.83904288
137Rib fusion (HP:0000902)1.83475509
138Patchy hypopigmentation of hair (HP:0011365)1.83403527
139Keratoconus (HP:0000563)1.83314375
140Increased corneal curvature (HP:0100692)1.83314375
141Meningitis (HP:0001287)1.83186862
142Abnormality of midbrain morphology (HP:0002418)1.81042863
143Molar tooth sign on MRI (HP:0002419)1.81042863
144Retinal dysplasia (HP:0007973)1.80058390
145Intellectual disability, severe (HP:0010864)1.77002681
146Anterior segment dysgenesis (HP:0007700)1.74966294
147Abnormality of T cell physiology (HP:0011840)1.74896492
148Tongue fasciculations (HP:0001308)1.74391874
149Cerebral palsy (HP:0100021)1.74096055
150Lactic acidosis (HP:0003128)1.73964519
151Abnormality of the renal collecting system (HP:0004742)1.73806450
152Agnosia (HP:0010524)1.73736123
153Cerebral hypomyelination (HP:0006808)1.73129056
154Congenital primary aphakia (HP:0007707)1.72868401
155Brushfield spots (HP:0001088)1.72642500
156Renal Fanconi syndrome (HP:0001994)1.72142653
157Abnormality of the preputium (HP:0100587)1.72068085
158Confusion (HP:0001289)1.70693448
159High pitched voice (HP:0001620)1.67814546
160Dry hair (HP:0011359)1.66797095
161Type 2 muscle fiber atrophy (HP:0003554)1.66577658
162Duplicated collecting system (HP:0000081)1.66013897
163Exercise intolerance (HP:0003546)1.65555687
164Macrocytic anemia (HP:0001972)1.65453684
165Abnormal biliary tract physiology (HP:0012439)1.64982817
166Bile duct proliferation (HP:0001408)1.64982817
167Abnormality of the aortic arch (HP:0012303)1.64563626
168Prominent supraorbital ridges (HP:0000336)1.64089063
169Short femoral neck (HP:0100864)1.63035642
170Asplenia (HP:0001746)1.62614451
171Preaxial hand polydactyly (HP:0001177)1.62237795
172Granulocytopenia (HP:0001913)1.62236489
173Abnormality of the diencephalon (HP:0010662)1.61536576
174Gait imbalance (HP:0002141)1.61227695
175Basal ganglia calcification (HP:0002135)1.60443035
176Alkalosis (HP:0001948)1.59911201
177Hemiparesis (HP:0001269)1.59602110
178Pachygyria (HP:0001302)1.59601125
179Abnormality of the ileum (HP:0001549)1.59365855
180Chronic otitis media (HP:0000389)1.59275283
181Abnormality of macrophages (HP:0004311)1.58589695
182Myelodysplasia (HP:0002863)1.58341266
183Bilateral microphthalmos (HP:0007633)1.57962618
184White forelock (HP:0002211)1.57910268
185Megalocornea (HP:0000485)1.57760919
186Abnormality of the vitreous humor (HP:0004327)1.57568451
187Turricephaly (HP:0000262)1.57434858
188Widely spaced teeth (HP:0000687)1.57039966
189Polyuria (HP:0000103)1.56238657

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.22545794
2WNK43.41967168
3DAPK23.34739440
4TRIB33.31770970
5FRK3.04742602
6FLT32.89332479
7IRAK42.62974743
8CAMK1D2.51844976
9CAMKK12.31130387
10EEF2K2.27953563
11SIK22.20177461
12VRK12.19674996
13MKNK22.17717788
14MAPK152.15021963
15PASK2.08562050
16CASK2.02087522
17INSRR1.97047816
18KIT1.96646436
19TXK1.92251158
20IRAK31.91445516
21TLK11.91155639
22MKNK11.86306592
23TEC1.78679445
24MAP3K121.77482081
25ADRBK21.76866371
26PIM21.73600932
27CAMK1G1.70230792
28TYRO31.67378306
29BMPR1B1.64895415
30TNIK1.63147166
31MAP4K11.57466401
32ZAK1.57001320
33MAP3K141.55296603
34ADRBK11.53106415
35DYRK31.53056671
36CDK191.51329003
37YES11.51017881
38AKT31.49742063
39SRPK11.38926976
40MAPKAPK31.38723124
41NME21.37729352
42BTK1.35923757
43PRPF4B1.33582460
44JAK31.32533974
45EIF2AK31.31599807
46PINK11.30828927
47ZAP701.28376145
48NTRK31.27225030
49BRAF1.25095810
50PIK3CG1.24862406
51BRSK21.23165070
52CDK81.19664656
53ARAF1.18269361
54MAP2K71.16792117
55MAP3K71.16776431
56TYK21.15082633
57NTRK21.14521602
58NEK21.13384749
59TSSK61.11197483
60ICK1.09482162
61IKBKE1.07715944
62CLK11.07538536
63MAP2K21.06069013
64CAMK11.05569678
65MARK11.05539067
66PNCK1.03543264
67IKBKB1.02776118
68WNK11.02648338
69NLK1.02257156
70SYK1.01907020
71EIF2AK21.01759204
72CCNB10.99365792
73SIK30.98217499
74ERBB30.93966021
75PTK2B0.92931177
76MET0.92803003
77IRAK10.91684408
78BUB10.91661111
79NME10.90996596
80MUSK0.89853646
81MAPK110.87932045
82BMPR20.87914153
83PLK40.87333466
84IRAK20.87248086
85MAP2K10.86990326
86PAK60.86108644
87TNK20.85763496
88TESK20.85446794
89NTRK10.83754200
90MAP3K110.83502787
91TAOK30.82170872
92DYRK20.82056910
93PRKD20.78582508
94LYN0.78001264
95SIK10.76240307
96ACVR1B0.74932227
97NEK60.74706753
98CDK70.74040617
99TGFBR10.74015547
100CAMK40.73831432
101NEK90.73468987
102WEE10.71807703
103BLK0.71571595
104STK110.71419498
105MAPK130.71295702
106SGK20.71113164
107CDC42BPA0.69965085
108PTK60.67975373
109ATR0.67342532
110HIPK20.66152432
111PIK3CA0.65692269
112TBK10.65661530
113PRKAA10.65002063
114BMX0.64036804
115MYLK0.63829413
116CAMKK20.62952042
117STK390.62124755
118PRKCG0.61232988
119CSF1R0.61138604
120PIM10.61075342
121MAP2K60.60549957
122OXSR10.59489516
123PRKCI0.59275602
124MATK0.58619668
125PRKAA20.58334494
126RPS6KA20.57707912
127MAP3K130.57502829
128MARK20.56981024
129PHKG10.56538936
130PHKG20.56538936
131PKN10.55132590
132LIMK10.54372505
133PRKCH0.54028843
134MAPKAPK50.53591462
135MAP2K40.53232204
136PRKD30.53139581
137CHUK0.52924968
138GRK70.52710090
139LCK0.52655526
140PLK30.51704642
141RPS6KA50.51465987
142TRPM70.51434447
143TESK10.50817336
144CSNK2A10.50342435
145PRKCZ0.50241089
146EIF2AK10.49536231
147RPS6KA60.48656543
148MST40.47772675
149GRK10.46862799
150CHEK20.46674242
151UHMK10.44633652
152PDGFRB0.44416102
153MELK0.44015781
154RPS6KC10.43251534
155RPS6KL10.43251534
156WNK30.42873059
157SGK4940.42168497
158SGK2230.42168497
159PDPK10.41896757
160RPS6KA40.41197292
161STK380.41103345
162MAPK120.41095395
163PAK30.35078451
164EPHB20.34986612
165MTOR0.34066092
166ITK0.33506856
167EPHA40.32145574
168ERBB20.32098022
169MAP3K40.29693510
170PDK10.29083346
171CAMK2A0.28921772
172MAPK80.28475474

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.93482347
2Ribosome_Homo sapiens_hsa030103.78887272
3RNA polymerase_Homo sapiens_hsa030203.12872246
4DNA replication_Homo sapiens_hsa030303.05282660
5Proteasome_Homo sapiens_hsa030502.97869564
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.87505665
7Mismatch repair_Homo sapiens_hsa034302.79123446
8Base excision repair_Homo sapiens_hsa034102.57153053
9Selenocompound metabolism_Homo sapiens_hsa004502.54193436
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.52924741
11Nitrogen metabolism_Homo sapiens_hsa009102.52856439
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.52223927
13Homologous recombination_Homo sapiens_hsa034402.49180774
14Nicotine addiction_Homo sapiens_hsa050332.38645470
15Pyrimidine metabolism_Homo sapiens_hsa002402.30390558
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.21763927
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.17031144
18ABC transporters_Homo sapiens_hsa020102.13545805
19Oxidative phosphorylation_Homo sapiens_hsa001902.06242793
20Fanconi anemia pathway_Homo sapiens_hsa034601.98241364
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.98155315
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.95723680
23Spliceosome_Homo sapiens_hsa030401.92630810
24Nucleotide excision repair_Homo sapiens_hsa034201.89482298
25Morphine addiction_Homo sapiens_hsa050321.83941489
26Non-homologous end-joining_Homo sapiens_hsa034501.78460977
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75575345
28Parkinsons disease_Homo sapiens_hsa050121.73294312
29Basal transcription factors_Homo sapiens_hsa030221.71833903
30Butanoate metabolism_Homo sapiens_hsa006501.70344338
31Ether lipid metabolism_Homo sapiens_hsa005651.70331820
32Insulin secretion_Homo sapiens_hsa049111.66002198
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51569618
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51240542
35Purine metabolism_Homo sapiens_hsa002301.49974951
36Folate biosynthesis_Homo sapiens_hsa007901.49695091
37Glutamatergic synapse_Homo sapiens_hsa047241.48838224
38Circadian entrainment_Homo sapiens_hsa047131.48786245
39Primary immunodeficiency_Homo sapiens_hsa053401.46031313
40Huntingtons disease_Homo sapiens_hsa050161.43285428
41Regulation of autophagy_Homo sapiens_hsa041401.41846585
42Other glycan degradation_Homo sapiens_hsa005111.37755276
43RNA degradation_Homo sapiens_hsa030181.36490134
44Taste transduction_Homo sapiens_hsa047421.34507931
45Tryptophan metabolism_Homo sapiens_hsa003801.29887399
46Calcium signaling pathway_Homo sapiens_hsa040201.29485506
47Ovarian steroidogenesis_Homo sapiens_hsa049131.28000266
48Allograft rejection_Homo sapiens_hsa053301.27733660
49Fatty acid biosynthesis_Homo sapiens_hsa000611.26738134
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25038224
51GABAergic synapse_Homo sapiens_hsa047271.24848218
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19090317
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17256767
54Lysine degradation_Homo sapiens_hsa003101.16706598
55Cholinergic synapse_Homo sapiens_hsa047251.15733735
56Histidine metabolism_Homo sapiens_hsa003401.14465042
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.11110929
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06996868
59Gastric acid secretion_Homo sapiens_hsa049711.05950043
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05746697
61Vibrio cholerae infection_Homo sapiens_hsa051101.05723747
62Alzheimers disease_Homo sapiens_hsa050101.05416095
63Type I diabetes mellitus_Homo sapiens_hsa049401.05067120
64Olfactory transduction_Homo sapiens_hsa047401.04227503
65Herpes simplex infection_Homo sapiens_hsa051681.03338743
66N-Glycan biosynthesis_Homo sapiens_hsa005101.02923752
67VEGF signaling pathway_Homo sapiens_hsa043701.02801045
68One carbon pool by folate_Homo sapiens_hsa006701.02127637
69RNA transport_Homo sapiens_hsa030131.01870727
70Serotonergic synapse_Homo sapiens_hsa047261.01066088
71Glycerolipid metabolism_Homo sapiens_hsa005611.00971927
72Arachidonic acid metabolism_Homo sapiens_hsa005900.99963261
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99880838
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99065455
75Cocaine addiction_Homo sapiens_hsa050300.97807162
76Measles_Homo sapiens_hsa051620.97359776
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.95913428
78Cell cycle_Homo sapiens_hsa041100.95472330
79Epstein-Barr virus infection_Homo sapiens_hsa051690.95425268
80Dopaminergic synapse_Homo sapiens_hsa047280.95157494
81Oxytocin signaling pathway_Homo sapiens_hsa049210.92237646
82Autoimmune thyroid disease_Homo sapiens_hsa053200.90842910
83Bile secretion_Homo sapiens_hsa049760.89946457
84Basal cell carcinoma_Homo sapiens_hsa052170.89515504
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.89106620
86Bladder cancer_Homo sapiens_hsa052190.88344159
87Long-term depression_Homo sapiens_hsa047300.86218355
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85736086
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85394858
90Legionellosis_Homo sapiens_hsa051340.85264066
91Dorso-ventral axis formation_Homo sapiens_hsa043200.84301404
92Hematopoietic cell lineage_Homo sapiens_hsa046400.83487235
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82576246
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.82506761
95Salivary secretion_Homo sapiens_hsa049700.82197207
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79659163
97Axon guidance_Homo sapiens_hsa043600.78758052
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77726785
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76057346
100Collecting duct acid secretion_Homo sapiens_hsa049660.75191906
101cAMP signaling pathway_Homo sapiens_hsa040240.74309126
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73912999
103Asthma_Homo sapiens_hsa053100.70452414
104Antigen processing and presentation_Homo sapiens_hsa046120.69690967
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69103350
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68744435
107MAPK signaling pathway_Homo sapiens_hsa040100.68259182
108Amphetamine addiction_Homo sapiens_hsa050310.66142009
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65193108
110Graft-versus-host disease_Homo sapiens_hsa053320.65151488
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64903008
112Rheumatoid arthritis_Homo sapiens_hsa053230.63314316
113Hedgehog signaling pathway_Homo sapiens_hsa043400.63078621
114p53 signaling pathway_Homo sapiens_hsa041150.62557807
115Sulfur metabolism_Homo sapiens_hsa009200.62087103
116Vitamin digestion and absorption_Homo sapiens_hsa049770.61903759
117GnRH signaling pathway_Homo sapiens_hsa049120.61483175
118Type II diabetes mellitus_Homo sapiens_hsa049300.60742432
119Sphingolipid metabolism_Homo sapiens_hsa006000.60722414
120Leishmaniasis_Homo sapiens_hsa051400.60261959
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59161551
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59115244
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58488288
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57420889
125Thyroid hormone synthesis_Homo sapiens_hsa049180.54980166
126Phagosome_Homo sapiens_hsa041450.54159662
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.53655612
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53567129
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53467293
130Metabolic pathways_Homo sapiens_hsa011000.53108262
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52801548
132Estrogen signaling pathway_Homo sapiens_hsa049150.52570069
133Hippo signaling pathway_Homo sapiens_hsa043900.51842816
134Fatty acid elongation_Homo sapiens_hsa000620.49565477
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49306576
136Influenza A_Homo sapiens_hsa051640.48639004
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48423374
138Lysosome_Homo sapiens_hsa041420.48112329
139Mineral absorption_Homo sapiens_hsa049780.47821317
140Sulfur relay system_Homo sapiens_hsa041220.47700477
141Phototransduction_Homo sapiens_hsa047440.47148702
142Pertussis_Homo sapiens_hsa051330.46544281
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45424736
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.45277401
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.44612443
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42876020
147beta-Alanine metabolism_Homo sapiens_hsa004100.41900759
148Arginine and proline metabolism_Homo sapiens_hsa003300.41304697
149Fat digestion and absorption_Homo sapiens_hsa049750.40667389
150Glycosaminoglycan degradation_Homo sapiens_hsa005310.39944232
151Apoptosis_Homo sapiens_hsa042100.39846775
152Phospholipase D signaling pathway_Homo sapiens_hsa040720.38424592
153Galactose metabolism_Homo sapiens_hsa000520.37589483
154Shigellosis_Homo sapiens_hsa051310.37152245
155cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36455913
156mRNA surveillance pathway_Homo sapiens_hsa030150.34889072
157Linoleic acid metabolism_Homo sapiens_hsa005910.34541460
158Circadian rhythm_Homo sapiens_hsa047100.34520112
159Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34151592
160Ras signaling pathway_Homo sapiens_hsa040140.34100194
161Synaptic vesicle cycle_Homo sapiens_hsa047210.34042068
162Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33365140
163Systemic lupus erythematosus_Homo sapiens_hsa053220.33143497
164Notch signaling pathway_Homo sapiens_hsa043300.32977947
165TNF signaling pathway_Homo sapiens_hsa046680.32384328
166Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31890465
167Peroxisome_Homo sapiens_hsa041460.30528893
168Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30142882
169Drug metabolism - other enzymes_Homo sapiens_hsa009830.29989565
170Acute myeloid leukemia_Homo sapiens_hsa052210.29549162
171Caffeine metabolism_Homo sapiens_hsa002320.29266341
172Melanogenesis_Homo sapiens_hsa049160.28923008
173Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28629126
174Pentose phosphate pathway_Homo sapiens_hsa000300.28515221
175Choline metabolism in cancer_Homo sapiens_hsa052310.28460855
176Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26719021
177Alcoholism_Homo sapiens_hsa050340.26475530
178Chemical carcinogenesis_Homo sapiens_hsa052040.25510590
179Hepatitis B_Homo sapiens_hsa051610.24518932

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