PDE10A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic transmission, dopaminergic (GO:0001963)6.41504484
2prepulse inhibition (GO:0060134)6.34341290
3regulation of synapse structural plasticity (GO:0051823)6.24733108
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.78187625
5striatum development (GO:0021756)5.69886972
6adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.47721767
7adenosine receptor signaling pathway (GO:0001973)5.45352901
8locomotory exploration behavior (GO:0035641)5.37532675
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.09800779
10regulation of short-term neuronal synaptic plasticity (GO:0048172)5.06114069
11regulation of long-term neuronal synaptic plasticity (GO:0048169)4.96498644
12auditory behavior (GO:0031223)4.90354811
13negative regulation of cytosolic calcium ion concentration (GO:0051481)4.86887344
14response to amphetamine (GO:0001975)4.86850370
15synaptic vesicle maturation (GO:0016188)4.84538145
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.83062954
17behavioral response to cocaine (GO:0048148)4.77646351
18vocalization behavior (GO:0071625)4.76467722
19positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.71131168
20dopamine receptor signaling pathway (GO:0007212)4.68639396
21regulation of glutamate receptor signaling pathway (GO:1900449)4.66529656
22negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.66471088
23neurotransmitter-gated ion channel clustering (GO:0072578)4.63188303
24detection of light stimulus involved in visual perception (GO:0050908)4.57277134
25detection of light stimulus involved in sensory perception (GO:0050962)4.57277134
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.56858587
27regulation of neuronal synaptic plasticity (GO:0048168)4.51049608
28positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.50312110
29regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.49587299
30regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.49587299
31substrate-independent telencephalic tangential migration (GO:0021826)4.46164210
32substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.46164210
33regulation of dendritic spine morphogenesis (GO:0061001)4.42187467
34positive regulation of synaptic transmission, GABAergic (GO:0032230)4.39076816
35neuron-neuron synaptic transmission (GO:0007270)4.31479126
36positive regulation of neurotransmitter transport (GO:0051590)4.28925445
37ionotropic glutamate receptor signaling pathway (GO:0035235)4.20996767
38response to auditory stimulus (GO:0010996)4.19549098
39neuromuscular process controlling balance (GO:0050885)4.18915842
40regulation of synaptic transmission, glutamatergic (GO:0051966)4.10421290
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.07404014
42regulation of neurotransmitter uptake (GO:0051580)4.04246897
43G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.03059140
44peristalsis (GO:0030432)4.02105872
45regulation of glutamate secretion (GO:0014048)4.01504019
46protein localization to synapse (GO:0035418)4.00491868
47regulation of excitatory postsynaptic membrane potential (GO:0060079)4.00071623
48synaptic vesicle exocytosis (GO:0016079)3.99755933
49phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.97743550
50long-term memory (GO:0007616)3.97689866
51dendritic spine morphogenesis (GO:0060997)3.94913140
52synaptic transmission, glutamatergic (GO:0035249)3.94460461
53synaptic vesicle docking involved in exocytosis (GO:0016081)3.92120616
54regulation of synaptic vesicle exocytosis (GO:2000300)3.89010404
55transmission of nerve impulse (GO:0019226)3.87295758
56regulation of female receptivity (GO:0045924)3.84581462
57positive regulation of membrane potential (GO:0045838)3.83164794
58exploration behavior (GO:0035640)3.82137334
59neurotransmitter secretion (GO:0007269)3.80767124
60neuronal action potential propagation (GO:0019227)3.78935392
61presynaptic membrane assembly (GO:0097105)3.74624015
62behavioral response to nicotine (GO:0035095)3.74368716
63response to histamine (GO:0034776)3.72223535
64positive regulation of neurotransmitter secretion (GO:0001956)3.71946425
65visual learning (GO:0008542)3.70538937
66regulation of postsynaptic membrane potential (GO:0060078)3.69049599
67glutamate receptor signaling pathway (GO:0007215)3.68996485
68mechanosensory behavior (GO:0007638)3.66856738
69negative regulation of dendrite development (GO:2000171)3.61881297
70behavioral defense response (GO:0002209)3.59066954
71behavioral fear response (GO:0001662)3.59066954
72neuronal ion channel clustering (GO:0045161)3.57271571
73regulation of synaptic plasticity (GO:0048167)3.56961499
74activation of protein kinase A activity (GO:0034199)3.56275357
75regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.54574859
76postsynaptic membrane organization (GO:0001941)3.51494082
77layer formation in cerebral cortex (GO:0021819)3.51404175
78membrane hyperpolarization (GO:0060081)3.50426506
79* cAMP catabolic process (GO:0006198)3.49998666
80visual behavior (GO:0007632)3.49901005
81negative regulation of translation, ncRNA-mediated (GO:0040033)3.47254366
82regulation of translation, ncRNA-mediated (GO:0045974)3.47254366
83negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.47254366
84regulation of voltage-gated calcium channel activity (GO:1901385)3.46452603
85regulation of synaptic vesicle transport (GO:1902803)3.45632416
86establishment of protein localization to Golgi (GO:0072600)3.41726280
87gamma-aminobutyric acid transport (GO:0015812)3.41413055
88long-term synaptic potentiation (GO:0060291)3.40297575
89female mating behavior (GO:0060180)3.38887072
90response to amine (GO:0014075)3.37852651
91regulation of norepinephrine secretion (GO:0014061)3.35538450
92mating behavior (GO:0007617)3.35452850
93regulation of dendritic spine development (GO:0060998)3.35003022
94regulation of synaptic transmission, GABAergic (GO:0032228)3.33422392
95axonal fasciculation (GO:0007413)3.31225713
96neuron cell-cell adhesion (GO:0007158)3.30415099
97presynaptic membrane organization (GO:0097090)3.29767385
98neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.29382605
99regulation of Rap GTPase activity (GO:0032317)3.26327619
100cAMP biosynthetic process (GO:0006171)3.24843601
101learning (GO:0007612)3.23828392
102* cAMP metabolic process (GO:0046058)3.23002508
103regulation of synaptic transmission, dopaminergic (GO:0032225)3.22310014
104calcium ion import (GO:0070509)3.19738375
105membrane depolarization (GO:0051899)3.19723047
106fear response (GO:0042596)3.17657622
107dendrite morphogenesis (GO:0048813)3.17541852
108membrane depolarization during action potential (GO:0086010)3.17093855
109glutamate secretion (GO:0014047)3.15868927
110negative regulation of amino acid transport (GO:0051956)3.14512420
111drinking behavior (GO:0042756)3.13119198
112protein polyglutamylation (GO:0018095)3.11077312
113neuromuscular process (GO:0050905)3.10846603
114positive regulation of synaptic transmission (GO:0050806)3.09026608
115central nervous system projection neuron axonogenesis (GO:0021952)3.04601255
116* cyclic nucleotide catabolic process (GO:0009214)3.01782581
117protein targeting to Golgi (GO:0000042)3.00610487
118pyrimidine nucleobase catabolic process (GO:0006208)2.91268614
119limb development (GO:0060173)2.90959432
120appendage development (GO:0048736)2.90959432
121central nervous system neuron axonogenesis (GO:0021955)2.87455734
122G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.87147165
123neuron recognition (GO:0008038)2.86557055
124retrograde transport, vesicle recycling within Golgi (GO:0000301)2.84594768
125cellular response to sterol (GO:0036315)2.80951686
126alanine transport (GO:0032328)2.69167700
127artery development (GO:0060840)2.68126233
128proline transport (GO:0015824)2.67055594
129regulation of cilium movement (GO:0003352)2.66037580
130cellular response to cholesterol (GO:0071397)2.61967515
131protein localization to Golgi apparatus (GO:0034067)2.59011147
132cochlea development (GO:0090102)2.57817001
133response to pheromone (GO:0019236)2.55888619
134microtubule severing (GO:0051013)2.55857066
135cranial nerve morphogenesis (GO:0021602)2.55674122
136limb bud formation (GO:0060174)2.54241948
137negative regulation of axon guidance (GO:1902668)2.53747819
138establishment of nucleus localization (GO:0040023)2.52233858
139neuromuscular synaptic transmission (GO:0007274)2.48425400
140nucleobase catabolic process (GO:0046113)2.47869581
141retinal ganglion cell axon guidance (GO:0031290)2.47045897
142sperm motility (GO:0030317)2.46087435
143inner ear receptor stereocilium organization (GO:0060122)2.45186833
144somite rostral/caudal axis specification (GO:0032525)2.44489296
145synapse assembly (GO:0007416)2.43496417
146regulation of hippo signaling (GO:0035330)2.43429402
147regulation of sarcomere organization (GO:0060297)2.40439526
148negative regulation of axon extension involved in axon guidance (GO:0048843)2.37220786
149regulation of axon guidance (GO:1902667)2.36280499
150negative regulation of synaptic transmission, GABAergic (GO:0032229)2.35380739
151retina layer formation (GO:0010842)2.35316357
152nonmotile primary cilium assembly (GO:0035058)2.34946756
153regulation of action potential (GO:0098900)2.33700082
154L-fucose catabolic process (GO:0042355)2.32823314
155fucose catabolic process (GO:0019317)2.32823314
156L-fucose metabolic process (GO:0042354)2.32823314
157C4-dicarboxylate transport (GO:0015740)2.32008940
158intraciliary transport (GO:0042073)2.30871546
159acrosome reaction (GO:0007340)2.27466193
160cell migration in hindbrain (GO:0021535)2.26631062
161urinary tract smooth muscle contraction (GO:0014848)2.26559481
162dendrite development (GO:0016358)2.26463765
163acrosome assembly (GO:0001675)2.24956780
164spinal cord motor neuron differentiation (GO:0021522)2.24747033
165spinal cord development (GO:0021510)2.24550527
166regulation of axon extension involved in axon guidance (GO:0048841)2.24035303
167head development (GO:0060322)2.22616193
168sympathetic nervous system development (GO:0048485)2.21667364
169somite development (GO:0061053)2.21376144
170axonogenesis (GO:0007409)2.18290826
171tachykinin receptor signaling pathway (GO:0007217)2.17003487
172cAMP-mediated signaling (GO:0019933)2.16213908
173startle response (GO:0001964)2.14792566
174reflex (GO:0060004)2.14568134
175gamma-aminobutyric acid signaling pathway (GO:0007214)2.13736146
176cilium assembly (GO:0042384)2.13350058
177prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.12674156
178synapse organization (GO:0050808)2.12354692
179cilium organization (GO:0044782)2.12320285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.03340527
2* RARB_27405468_Chip-Seq_BRAIN_Mouse3.89331505
3GBX2_23144817_ChIP-Seq_PC3_Human3.44183228
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11722333
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05874362
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93302270
7DROSHA_22980978_ChIP-Seq_HELA_Human2.84565219
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.77760491
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66132131
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66081500
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66081500
12REST_21632747_ChIP-Seq_MESCs_Mouse2.64302667
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58876812
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54554637
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54397835
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51358569
17* EZH2_27304074_Chip-Seq_ESCs_Mouse2.41134845
18FUS_26573619_Chip-Seq_HEK293_Human2.36787133
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28091882
20* CBX2_27304074_Chip-Seq_ESCs_Mouse2.27954312
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27036142
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24874403
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22738189
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.20671660
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.17258658
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.17134554
27AR_21572438_ChIP-Seq_LNCaP_Human2.13907729
28* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11261770
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07968058
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05256034
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92845451
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.92812487
33IGF1R_20145208_ChIP-Seq_DFB_Human1.87590645
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.86721350
35VDR_22108803_ChIP-Seq_LS180_Human1.86216820
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.84803433
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77069289
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68226776
39* RNF2_27304074_Chip-Seq_NSC_Mouse1.67342506
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63487046
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63099038
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60548144
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57270541
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56427684
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56303086
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56111423
47EWS_26573619_Chip-Seq_HEK293_Human1.53910377
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52294876
49TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45646397
50* SMAD4_21799915_ChIP-Seq_A2780_Human1.44688255
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44384534
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44384534
53TAF15_26573619_Chip-Seq_HEK293_Human1.42898935
54BCAT_22108803_ChIP-Seq_LS180_Human1.41662225
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36895516
56* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36593644
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36171094
58* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35777812
59* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33679818
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32822875
61CBP_20019798_ChIP-Seq_JUKART_Human1.32822875
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32068513
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.30673771
64KDM2B_26808549_Chip-Seq_K562_Human1.29952245
65* SMAD3_21741376_ChIP-Seq_EPCs_Human1.29909037
66ER_23166858_ChIP-Seq_MCF-7_Human1.27631037
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27474232
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27064519
69STAT3_23295773_ChIP-Seq_U87_Human1.26880639
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26262583
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26198716
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26184284
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25860661
74* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25664571
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.25085957
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24903336
77* AR_19668381_ChIP-Seq_PC3_Human1.23878389
78* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19975450
79* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17547117
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14543062
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13952533
82CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13708500
83* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13594988
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13149737
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.12844600
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11830375
87P300_19829295_ChIP-Seq_ESCs_Human1.11608600
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11452823
89* RING1B_27294783_Chip-Seq_NPCs_Mouse1.10829308
90AHR_22903824_ChIP-Seq_MCF-7_Human1.10627045
91TCF4_22108803_ChIP-Seq_LS180_Human1.09807096
92TP53_18474530_ChIP-ChIP_U2OS_Human1.09459076
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.09304710
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08730666
95TBL1_22424771_ChIP-Seq_293T_Human1.08634380
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08417236
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08343408
98* TCF4_23295773_ChIP-Seq_U87_Human1.06598071
99ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05970205
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04815065
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03985840
102SMAD_19615063_ChIP-ChIP_OVARY_Human1.03566114
103* SMAD3_21741376_ChIP-Seq_HESCs_Human1.03155633
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02368275
105CTCF_27219007_Chip-Seq_Bcells_Human1.01432051
106* KDM2B_26808549_Chip-Seq_REH_Human1.01294936
107MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01249329
108AR_25329375_ChIP-Seq_VCAP_Human1.00912818
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00709342
110SOX9_26525672_Chip-Seq_HEART_Mouse1.00664983
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00288314
112* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00230501
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98806038
114ARNT_22903824_ChIP-Seq_MCF-7_Human0.98621455
115RUNX2_22187159_ChIP-Seq_PCA_Human0.96941273
116RXR_22108803_ChIP-Seq_LS180_Human0.96496646
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96450098
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.95698512
119TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95414564
120ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94341810
121CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94152012
122* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93017345
123* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92886477
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92775125
125TP53_16413492_ChIP-PET_HCT116_Human0.92708554
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92639630
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.92133340
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.91849655
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91346270
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90332695
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90073857
132GATA1_26923725_Chip-Seq_HPCs_Mouse0.89898455
133* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89562518
134ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89388587
135* KLF4_19829295_ChIP-Seq_ESCs_Human0.88057994
136ZNF274_21170338_ChIP-Seq_K562_Hela0.87876139
137TET1_21490601_ChIP-Seq_MESCs_Mouse0.86603825
138PRDM14_20953172_ChIP-Seq_ESCs_Human0.86138569
139* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85600324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy9.60708673
2MP0004859_abnormal_synaptic_plasticity6.12809234
3MP0003880_abnormal_central_pattern4.02096733
4MP0003635_abnormal_synaptic_transmissio4.01999300
5MP0009745_abnormal_behavioral_response3.69076360
6* MP0002063_abnormal_learning/memory/cond3.39029967
7MP0004270_analgesia3.27099567
8MP0001529_abnormal_vocalization2.98267036
9MP0002064_seizures2.91274817
10MP0009046_muscle_twitch2.85572725
11MP0001486_abnormal_startle_reflex2.75409059
12* MP0002572_abnormal_emotion/affect_behav2.70925856
13MP0002909_abnormal_adrenal_gland2.57285772
14MP0002272_abnormal_nervous_system2.45668287
15MP0001968_abnormal_touch/_nociception2.44944269
16MP0005423_abnormal_somatic_nervous2.30769179
17MP0005646_abnormal_pituitary_gland2.25140211
18MP0003136_yellow_coat_color2.14265127
19MP0002638_abnormal_pupillary_reflex2.09755259
20MP0005409_darkened_coat_color2.05629688
21MP0002734_abnormal_mechanical_nocicepti2.05031995
22MP0004924_abnormal_behavior2.01581120
23MP0005386_behavior/neurological_phenoty2.01581120
24MP0001501_abnormal_sleep_pattern1.97999760
25MP0002234_abnormal_pharynx_morphology1.94567164
26MP0000566_synostosis1.93773289
27MP0001188_hyperpigmentation1.79776865
28MP0008569_lethality_at_weaning1.72110010
29MP0001970_abnormal_pain_threshold1.69479036
30MP0000049_abnormal_middle_ear1.67658087
31MP0002733_abnormal_thermal_nociception1.66450627
32MP0004811_abnormal_neuron_physiology1.65729955
33MP0001984_abnormal_olfaction1.62388164
34MP0002736_abnormal_nociception_after1.58138217
35* MP0002557_abnormal_social/conspecific_i1.55714821
36MP0001440_abnormal_grooming_behavior1.55663305
37MP0006292_abnormal_olfactory_placode1.55625903
38MP0009780_abnormal_chondrocyte_physiolo1.54047014
39MP0003937_abnormal_limbs/digits/tail_de1.51418969
40MP0002067_abnormal_sensory_capabilities1.50481332
41MP0004133_heterotaxia1.50450051
42MP0000026_abnormal_inner_ear1.48117186
43MP0002938_white_spotting1.45439901
44MP0005253_abnormal_eye_physiology1.42491301
45MP0003119_abnormal_digestive_system1.36075280
46MP0003879_abnormal_hair_cell1.33784927
47MP0004885_abnormal_endolymph1.33113687
48MP0002735_abnormal_chemical_nociception1.32970650
49MP0003633_abnormal_nervous_system1.31728141
50MP0010030_abnormal_orbit_morphology1.31513652
51MP0001177_atelectasis1.30932442
52MP0002184_abnormal_innervation1.27521589
53MP0008874_decreased_physiological_sensi1.26935938
54MP0003075_altered_response_to1.26128938
55* MP0002066_abnormal_motor_capabilities/c1.24465978
56MP0001905_abnormal_dopamine_level1.23630655
57MP0002102_abnormal_ear_morphology1.23271737
58MP0000955_abnormal_spinal_cord1.22782676
59MP0000569_abnormal_digit_pigmentation1.22131459
60MP0000534_abnormal_ureter_morphology1.22080435
61MP0008872_abnormal_physiological_respon1.20435878
62MP0000013_abnormal_adipose_tissue1.15690663
63MP0005167_abnormal_blood-brain_barrier1.15328908
64MP0003755_abnormal_palate_morphology1.14967339
65MP0000778_abnormal_nervous_system1.14369640
66MP0003938_abnormal_ear_development1.13345357
67MP0002751_abnormal_autonomic_nervous1.13340690
68MP0002233_abnormal_nose_morphology1.13033850
69MP0009250_abnormal_appendicular_skeleto1.12834113
70MP0003861_abnormal_nervous_system1.12070129
71MP0003329_amyloid_beta_deposits1.12051711
72MP0006072_abnormal_retinal_apoptosis1.10975279
73MP0002882_abnormal_neuron_morphology1.10502561
74MP0005187_abnormal_penis_morphology1.10407569
75MP0005195_abnormal_posterior_eye1.08681972
76MP0001286_abnormal_eye_development1.06004566
77MP0004085_abnormal_heartbeat1.05632062
78MP0003942_abnormal_urinary_system1.04919650
79MP0005410_abnormal_fertilization1.02805383
80MP0005391_vision/eye_phenotype1.02483448
81MP0004858_abnormal_nervous_system1.01718049
82MP0003631_nervous_system_phenotype1.01323074
83MP0004145_abnormal_muscle_electrophysio1.00616057
84MP0003890_abnormal_embryonic-extraembry0.99810062
85MP0003283_abnormal_digestive_organ0.99757391
86MP0002697_abnormal_eye_size0.99423944
87MP0008961_abnormal_basal_metabolism0.98933701
88MP0002932_abnormal_joint_morphology0.97813080
89MP0005171_absent_coat_pigmentation0.97270295
90MP0003385_abnormal_body_wall0.96089758
91MP0000383_abnormal_hair_follicle0.95207631
92MP0003935_abnormal_craniofacial_develop0.93116125
93MP0005367_renal/urinary_system_phenotyp0.92551959
94MP0000516_abnormal_urinary_system0.92551959
95MP0003690_abnormal_glial_cell0.92457004
96MP0003698_abnormal_male_reproductive0.92411856
97MP0004215_abnormal_myocardial_fiber0.91713500
98MP0000537_abnormal_urethra_morphology0.91284845
99MP0002069_abnormal_eating/drinking_beha0.90717360
100MP0002249_abnormal_larynx_morphology0.90424528
101MP0001502_abnormal_circadian_rhythm0.90081416
102MP0002152_abnormal_brain_morphology0.89767334
103MP0001293_anophthalmia0.89434100
104MP0002090_abnormal_vision0.89212739
105MP0010234_abnormal_vibrissa_follicle0.88968087
106MP0005535_abnormal_body_temperature0.86336907
107MP0000428_abnormal_craniofacial_morphol0.86304580
108MP0008789_abnormal_olfactory_epithelium0.85241029
109MP0002116_abnormal_craniofacial_bone0.82710711
110MP0005645_abnormal_hypothalamus_physiol0.82642208
111MP0003787_abnormal_imprinting0.82454014
112MP0004142_abnormal_muscle_tone0.80409547
113MP0000920_abnormal_myelination0.80029435
114MP0000631_abnormal_neuroendocrine_gland0.73039588
115MP0002229_neurodegeneration0.72796096
116MP0005394_taste/olfaction_phenotype0.71940749
117MP0005499_abnormal_olfactory_system0.71940749
118MP0003137_abnormal_impulse_conducting0.70385010
119MP0000751_myopathy0.68177045
120MP0003634_abnormal_glial_cell0.64552304
121MP0006276_abnormal_autonomic_nervous0.64120335
122MP0004742_abnormal_vestibular_system0.56372519
123MP0004043_abnormal_pH_regulation0.56175184
124MP0001485_abnormal_pinna_reflex0.55034501
125MP0001664_abnormal_digestion0.54487008
126MP0003632_abnormal_nervous_system0.54242141
127MP0005551_abnormal_eye_electrophysiolog0.53893177
128MP0001943_abnormal_respiration0.47743836
129MP0000604_amyloidosis0.45499137
130MP0005166_decreased_susceptibility_to0.45151769
131MP0001299_abnormal_eye_distance/0.43978241
132* MP0003956_abnormal_body_size0.43096858
133MP0002752_abnormal_somatic_nervous0.41399201
134MP0000003_abnormal_adipose_tissue0.41367291
135MP0010769_abnormal_survival0.40351148
136MP0005620_abnormal_muscle_contractility0.39840997
137MP0010770_preweaning_lethality0.38801785
138MP0002082_postnatal_lethality0.38801785
139MP0010768_mortality/aging0.37290492
140MP0003122_maternal_imprinting0.37217988
141MP0001963_abnormal_hearing_physiology0.37205163
142MP0000230_abnormal_systemic_arterial0.37164119
143MP0001765_abnormal_ion_homeostasis0.35925206
144MP0010386_abnormal_urinary_bladder0.35803595
145MP0004036_abnormal_muscle_relaxation0.35292103
146MP0004233_abnormal_muscle_weight0.34308425

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)9.70761517
2Focal motor seizures (HP:0011153)7.77036797
3Congenital stationary night blindness (HP:0007642)5.83270932
4Focal seizures (HP:0007359)5.68602953
5Abnormality of macular pigmentation (HP:0008002)5.19708422
6Severe visual impairment (HP:0001141)5.07090226
7Resting tremor (HP:0002322)4.88224263
8Hypoplasia of the fovea (HP:0007750)4.55853096
9Aplasia/Hypoplasia of the fovea (HP:0008060)4.55853096
10Torticollis (HP:0000473)4.55491058
11Central scotoma (HP:0000603)4.53005901
12Annular pancreas (HP:0001734)4.42264750
13Action tremor (HP:0002345)4.36276856
14Abnormal rod and cone electroretinograms (HP:0008323)4.17762698
15Poor eye contact (HP:0000817)4.14427970
16Visual hallucinations (HP:0002367)3.93998036
17Focal dystonia (HP:0004373)3.87695832
18Broad-based gait (HP:0002136)3.87656809
19Anxiety (HP:0000739)3.85067654
20Ankle clonus (HP:0011448)3.83688621
21Craniofacial dystonia (HP:0012179)3.83240587
22Dysdiadochokinesis (HP:0002075)3.79663372
23Abnormality of the fovea (HP:0000493)3.77370075
24Abnormal social behavior (HP:0012433)3.74878265
25Impaired social interactions (HP:0000735)3.74878265
26Impaired vibration sensation in the lower limbs (HP:0002166)3.68726889
27Gaze-evoked nystagmus (HP:0000640)3.65408381
28Scanning speech (HP:0002168)3.59351863
29Ankyloglossia (HP:0010296)3.57036764
30Depression (HP:0000716)3.56905950
31Dysmetric saccades (HP:0000641)3.52450675
32Epileptic encephalopathy (HP:0200134)3.50075251
33Urinary bladder sphincter dysfunction (HP:0002839)3.39226018
34Febrile seizures (HP:0002373)3.35756920
35Generalized tonic-clonic seizures (HP:0002069)3.33961923
36Prolonged QT interval (HP:0001657)3.25271471
37Stereotypic behavior (HP:0000733)3.17611737
38Absence seizures (HP:0002121)3.17311593
39Truncal ataxia (HP:0002078)3.09273530
40Dysmetria (HP:0001310)3.06236658
41Urinary urgency (HP:0000012)3.03829898
42Progressive cerebellar ataxia (HP:0002073)3.02292125
43Scotoma (HP:0000575)3.01330492
44Dialeptic seizures (HP:0011146)3.00715256
45Impaired smooth pursuit (HP:0007772)2.98396430
46Lower limb amyotrophy (HP:0007210)2.97659973
47Pointed chin (HP:0000307)2.97358941
48Postural instability (HP:0002172)2.94006787
49Aplasia/Hypoplasia of the macula (HP:0008059)2.87991677
50Atrioventricular block (HP:0001678)2.87807327
51Atonic seizures (HP:0010819)2.85239893
52Abnormal EKG (HP:0003115)2.83040916
53Intention tremor (HP:0002080)2.78075279
54Papilledema (HP:0001085)2.75867617
55Polygenic inheritance (HP:0010982)2.71825295
56Abnormality of midbrain morphology (HP:0002418)2.68077360
57Molar tooth sign on MRI (HP:0002419)2.68077360
58Spastic gait (HP:0002064)2.67956143
59Abnormal eating behavior (HP:0100738)2.66678744
60Abnormality of oral frenula (HP:0000190)2.65993737
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.65790204
62Abnormality of the ischium (HP:0003174)2.65746176
63Impaired vibratory sensation (HP:0002495)2.65630172
64Aplasia/Hypoplasia affecting the retina (HP:0008061)2.63710162
65Limb dystonia (HP:0002451)2.60171008
66Hyperventilation (HP:0002883)2.58847463
67Nephronophthisis (HP:0000090)2.57844479
68Albinism (HP:0001022)2.54647320
69Supranuclear gaze palsy (HP:0000605)2.50668028
70Limb hypertonia (HP:0002509)2.49326941
71Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.48535276
72Abnormality of ocular smooth pursuit (HP:0000617)2.47646117
73Megalencephaly (HP:0001355)2.47585802
74Bradykinesia (HP:0002067)2.45862263
75Decreased central vision (HP:0007663)2.40744892
76Cerebellar dysplasia (HP:0007033)2.40220282
77Distal lower limb amyotrophy (HP:0008944)2.39220492
78Clonus (HP:0002169)2.37212779
79Amblyopia (HP:0000646)2.37085948
80Heart block (HP:0012722)2.36533803
81Attenuation of retinal blood vessels (HP:0007843)2.34923397
82Short 4th metacarpal (HP:0010044)2.34651427
83Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.34651427
84Rib fusion (HP:0000902)2.33858631
85Retinal dysplasia (HP:0007973)2.32815764
86Hypoplastic ischia (HP:0003175)2.32413164
87Type II lissencephaly (HP:0007260)2.31898497
88Incomplete penetrance (HP:0003829)2.28918284
89Abnormality of the lower motor neuron (HP:0002366)2.26026895
90Abnormality of the renal medulla (HP:0100957)2.22048443
91Renal cortical cysts (HP:0000803)2.21961779
92Abnormality of the renal cortex (HP:0011035)2.19025199
93Chronic hepatic failure (HP:0100626)2.16928899
94Insidious onset (HP:0003587)2.15268031
95Termporal pattern (HP:0011008)2.15268031
96Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.15002679
97Abnormal atrioventricular conduction (HP:0005150)2.14992006
98Hemiparesis (HP:0001269)2.14979630
99Optic nerve hypoplasia (HP:0000609)2.14727556
100Midline defect of the nose (HP:0004122)2.14675441
101Pancreatic fibrosis (HP:0100732)2.14461547
102Lower limb muscle weakness (HP:0007340)2.13611904
103Abnormality of saccadic eye movements (HP:0000570)2.13587707
104Intestinal atresia (HP:0011100)2.13178854
105Mutism (HP:0002300)2.12805565
106Preaxial foot polydactyly (HP:0001841)2.12130953
107True hermaphroditism (HP:0010459)2.11526571
108Epileptiform EEG discharges (HP:0011182)2.09805420
109Progressive inability to walk (HP:0002505)2.08757325
110Cutaneous finger syndactyly (HP:0010554)2.08728801
111Genetic anticipation (HP:0003743)2.07984980
112EEG with generalized epileptiform discharges (HP:0011198)2.05725665
113Pancreatic cysts (HP:0001737)2.05423569
114Proximal tubulopathy (HP:0000114)2.03376363
115Status epilepticus (HP:0002133)2.02734905
116Abnormality of the 4th metacarpal (HP:0010012)2.02336940
117Drooling (HP:0002307)2.02115210
118Excessive salivation (HP:0003781)2.02115210
119Distal upper limb amyotrophy (HP:0007149)2.01982843
120Upper limb amyotrophy (HP:0009129)2.01982843
121Hypsarrhythmia (HP:0002521)2.01792400
122Pachygyria (HP:0001302)2.00672383
123Ventricular fibrillation (HP:0001663)2.00186336
124Hemiplegia (HP:0002301)1.99926335
125Short tibia (HP:0005736)1.99589147
126Abnormality of the pubic bones (HP:0003172)1.99114278
127Lower limb asymmetry (HP:0100559)1.97831184
128Truncus arteriosus (HP:0001660)1.97801837
129Primary atrial arrhythmia (HP:0001692)1.97233169
130Polydipsia (HP:0001959)1.96531061
131Abnormal drinking behavior (HP:0030082)1.96531061
132Atrial fibrillation (HP:0005110)1.94880503
133Bifid tongue (HP:0010297)1.94082282
134Tubulointerstitial nephritis (HP:0001970)1.93363636
135Fetal akinesia sequence (HP:0001989)1.92977256
136Bony spicule pigmentary retinopathy (HP:0007737)1.92426380
137Obsessive-compulsive behavior (HP:0000722)1.91041244
138Bowel incontinence (HP:0002607)1.90688604
139Neuronal loss in central nervous system (HP:0002529)1.88787526
140Neurofibrillary tangles (HP:0002185)1.86675640
141Tubular atrophy (HP:0000092)1.86669456
142Gait ataxia (HP:0002066)1.86355182
143Lissencephaly (HP:0001339)1.85352221
144Abnormality of the periventricular white matter (HP:0002518)1.85297802
145Anophthalmia (HP:0000528)1.85081781
146Increased corneal curvature (HP:0100692)1.84914040
147Keratoconus (HP:0000563)1.84914040
148Chorioretinal atrophy (HP:0000533)1.84810865
149Obstructive sleep apnea (HP:0002870)1.84803316
150Onion bulb formation (HP:0003383)1.83866157
151Sclerocornea (HP:0000647)1.83648970
152Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83302577
153Supraventricular tachycardia (HP:0004755)1.82768333
154Spinal canal stenosis (HP:0003416)1.81746378
155Oligodactyly (hands) (HP:0001180)1.80549618
156Blue irides (HP:0000635)1.78568554
157Bundle branch block (HP:0011710)1.77249934
158Dysphonia (HP:0001618)1.77018730
159Supraventricular arrhythmia (HP:0005115)1.76085204
160Astigmatism (HP:0000483)1.71508537
161Acute lymphatic leukemia (HP:0006721)1.70756714
162Medial flaring of the eyebrow (HP:0010747)1.70102868
163Genital tract atresia (HP:0001827)1.69919774
164Patellar aplasia (HP:0006443)1.69620138
165Gait imbalance (HP:0002141)1.68010345
166Median cleft lip (HP:0000161)1.67226949
167Protruding tongue (HP:0010808)1.67126234
168Preaxial hand polydactyly (HP:0001177)1.66393495
169Vaginal atresia (HP:0000148)1.65942928
170Partial agenesis of the corpus callosum (HP:0001338)1.65669672
171Abnormality of the aortic arch (HP:0012303)1.65617999
172Cutaneous syndactyly (HP:0012725)1.62957972
173Inability to walk (HP:0002540)1.61270355
174Small hand (HP:0200055)1.61260073
175Highly arched eyebrow (HP:0002553)1.61058770
176Aplasia/Hypoplasia of the lens (HP:0008063)1.58438378
177Absent speech (HP:0001344)1.57599909
178Bilateral microphthalmos (HP:0007633)1.56954588
179Postaxial hand polydactyly (HP:0001162)1.56301220
180Cystic liver disease (HP:0006706)1.56253358
181Aplasia/Hypoplasia of the patella (HP:0006498)1.52527396
182Morphological abnormality of the middle ear (HP:0008609)1.52321838
183Renal hypoplasia (HP:0000089)1.52100967
184Abnormality of the labia minora (HP:0012880)1.51267914
185Exotropia (HP:0000577)1.50123916
186Ectopic kidney (HP:0000086)1.49144709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.97178350
2FRK4.55764723
3NTRK34.18823889
4MAP3K93.18308354
5BRD43.01515185
6DAPK22.84137617
7RIPK42.71632351
8PRKD32.62529479
9KSR22.54829913
10PNCK2.54082260
11CAMKK12.49364663
12INSRR2.26032645
13NTRK12.16800820
14MINK12.15662812
15NTRK22.09918886
16MARK12.07974892
17MAP4K22.01854647
18CAMKK21.97602969
19MAP3K41.95453248
20FES1.93409740
21KSR11.77369444
22BMPR1B1.76599749
23STK391.72086756
24TAOK11.68834664
25TNIK1.66906265
26CDK51.59347813
27WNK41.57461601
28ACVR1B1.55657455
29MAP3K131.54594334
30DAPK11.53282463
31MAP3K21.52904313
32PAK61.51350838
33STK38L1.50061329
34ARAF1.49072751
35EPHB21.47088404
36CSNK1A1L1.41720841
37CAMK1G1.40204044
38MAP2K71.38913496
39ADRBK21.36885223
40SIK21.35308019
41TYRO31.33502359
42GRK11.25096612
43MKNK21.24570377
44PAK31.23773839
45PRPF4B1.18191312
46CSNK1G11.17735597
47SGK2231.16882016
48SGK4941.16882016
49AKT31.14226512
50LATS11.13452007
51CSNK1G31.12754868
52OXSR11.12501589
53SGK21.11518723
54RAF11.11090992
55BMPR21.10362881
56MET1.09570517
57MAP2K41.08414983
58DYRK21.06847386
59ZAK1.06048495
60SGK31.00559372
61PRKCH0.99851173
62STK380.96855251
63MAPK150.96335423
64PINK10.95221657
65MARK20.94845719
66ERBB30.94007120
67TIE10.93647808
68PLK40.93464862
69BCR0.92658023
70RIPK10.90577515
71SGK10.87731600
72MAPK130.86668374
73STK110.84549598
74PRKCG0.84535772
75CDK120.83037142
76RET0.82847668
77UHMK10.80967793
78DDR20.80003576
79CAMK2A0.79417030
80MKNK10.78881960
81CAMK2B0.78569984
82PDPK10.77039536
83CAMK1D0.76911751
84CDK180.76217297
85CDK150.74080166
86PKN10.72605563
87CAMK10.71588292
88PDK10.70977158
89LATS20.70815681
90CDK140.69797213
91MAP3K10.68819147
92PTK2B0.68549395
93NEK60.68275140
94EPHA30.67172672
95CASK0.64672643
96CDK11A0.62813406
97ALK0.62442244
98MAP2K10.62363110
99ADRBK10.61719370
100WEE10.61520263
101NEK10.60505663
102TGFBR10.59586465
103RPS6KA30.58151343
104FYN0.56648851
105MUSK0.55740721
106PRKCZ0.55388656
107TNK20.54513981
108TRIB30.54087858
109WNK10.53511666
110CAMK40.53336724
111LMTK20.53234108
112ROCK10.52302563
113MAPKAPK50.51780133
114PRKD20.51693157
115SCYL20.51248800
116MAP3K120.51051205
117GRK50.49602026
118MAPK100.49152242
119TLK10.48987676
120DMPK0.48175318
121MAPK70.47480104
122PHKG10.47257046
123PHKG20.47257046
124PRKG10.46413041
125CDK30.46250118
126PRKAA10.46191296
127BRSK10.45879889
128DAPK30.45254324
129CSNK1D0.44923196
130NUAK10.44388724
131CSNK1E0.43946221
132DYRK30.43729370
133NEK20.41998561
134MAP3K70.41587746
135BRSK20.41418568
136RPS6KB10.41157001
137TRPM70.41032266
138PRKCB0.39183824
139FGFR20.39164403
140NME10.38943110
141PRKCE0.38675567
142CAMK2D0.38248363
143PLK20.37415349
144CDC42BPA0.37154319
145PDGFRA0.36804670
146CAMK2G0.35486353
147BRAF0.35271406
148CSNK1G20.32691669
149RPS6KA20.32169531
150PRKACG0.30922883
151CSNK1A10.30264037
152WNK30.29597869
153MOS0.29430397
154* PRKACA0.28592721
155MAPK80.27635484
156HCK0.26485465
157PRKCA0.26061401
158DYRK1A0.25868120

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.79421171
2Nicotine addiction_Homo sapiens_hsa050332.86842451
3Circadian entrainment_Homo sapiens_hsa047132.86252237
4Amphetamine addiction_Homo sapiens_hsa050312.83388364
5* Morphine addiction_Homo sapiens_hsa050322.82741870
6Cocaine addiction_Homo sapiens_hsa050302.82575263
7GABAergic synapse_Homo sapiens_hsa047272.72004617
8Long-term potentiation_Homo sapiens_hsa047202.65439044
9Glutamatergic synapse_Homo sapiens_hsa047242.57220043
10Dopaminergic synapse_Homo sapiens_hsa047282.50778589
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42985991
12Synaptic vesicle cycle_Homo sapiens_hsa047212.42486144
13Cholinergic synapse_Homo sapiens_hsa047252.33063622
14Renin secretion_Homo sapiens_hsa049242.13646316
15Salivary secretion_Homo sapiens_hsa049702.10275212
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.99103528
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94464599
18Oxytocin signaling pathway_Homo sapiens_hsa049211.78242858
19Insulin secretion_Homo sapiens_hsa049111.77805696
20Gastric acid secretion_Homo sapiens_hsa049711.76915007
21Calcium signaling pathway_Homo sapiens_hsa040201.75666166
22Gap junction_Homo sapiens_hsa045401.72076990
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71809936
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71142772
25Serotonergic synapse_Homo sapiens_hsa047261.65031707
26Long-term depression_Homo sapiens_hsa047301.58794706
27Hedgehog signaling pathway_Homo sapiens_hsa043401.57673895
28Nitrogen metabolism_Homo sapiens_hsa009101.53620079
29Fatty acid biosynthesis_Homo sapiens_hsa000611.50766294
30Taste transduction_Homo sapiens_hsa047421.47720184
31GnRH signaling pathway_Homo sapiens_hsa049121.46375500
32cAMP signaling pathway_Homo sapiens_hsa040241.42787292
33Basal cell carcinoma_Homo sapiens_hsa052171.41693993
34Selenocompound metabolism_Homo sapiens_hsa004501.35389618
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30538078
36Hippo signaling pathway_Homo sapiens_hsa043901.25961305
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18406299
38Glioma_Homo sapiens_hsa052141.17780451
39Lysine degradation_Homo sapiens_hsa003101.16470054
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15281861
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13288048
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12221381
43Estrogen signaling pathway_Homo sapiens_hsa049151.10746784
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09878318
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08881404
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.08775823
47Type II diabetes mellitus_Homo sapiens_hsa049301.07332390
48Linoleic acid metabolism_Homo sapiens_hsa005911.05780212
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.04501595
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01212442
51Ether lipid metabolism_Homo sapiens_hsa005651.00320666
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00187637
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98389311
54Alcoholism_Homo sapiens_hsa050340.97793169
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95880577
56Melanogenesis_Homo sapiens_hsa049160.94953113
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.94383384
58Fanconi anemia pathway_Homo sapiens_hsa034600.93586981
59ErbB signaling pathway_Homo sapiens_hsa040120.92367577
60TGF-beta signaling pathway_Homo sapiens_hsa043500.90778533
61Non-small cell lung cancer_Homo sapiens_hsa052230.90559595
62Phototransduction_Homo sapiens_hsa047440.89351117
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89311412
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86177618
65Axon guidance_Homo sapiens_hsa043600.85052690
66Oocyte meiosis_Homo sapiens_hsa041140.84950247
67Basal transcription factors_Homo sapiens_hsa030220.83993671
68Dilated cardiomyopathy_Homo sapiens_hsa054140.83472643
69Pancreatic secretion_Homo sapiens_hsa049720.81318205
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.81296275
71Rap1 signaling pathway_Homo sapiens_hsa040150.80326354
72Thyroid hormone synthesis_Homo sapiens_hsa049180.77215344
73beta-Alanine metabolism_Homo sapiens_hsa004100.77119109
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76712538
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75400893
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74217438
77Dorso-ventral axis formation_Homo sapiens_hsa043200.73877843
78ECM-receptor interaction_Homo sapiens_hsa045120.72388367
79Choline metabolism in cancer_Homo sapiens_hsa052310.72292960
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69550397
81Tryptophan metabolism_Homo sapiens_hsa003800.67903307
82MAPK signaling pathway_Homo sapiens_hsa040100.67523310
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66545463
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.66484872
85ABC transporters_Homo sapiens_hsa020100.66110057
86Type I diabetes mellitus_Homo sapiens_hsa049400.65209222
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64015429
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63226118
89Cardiac muscle contraction_Homo sapiens_hsa042600.62908141
90Protein digestion and absorption_Homo sapiens_hsa049740.61631874
91VEGF signaling pathway_Homo sapiens_hsa043700.60773762
92Collecting duct acid secretion_Homo sapiens_hsa049660.60182131
93Chemokine signaling pathway_Homo sapiens_hsa040620.59894656
94Tight junction_Homo sapiens_hsa045300.59713858
95mTOR signaling pathway_Homo sapiens_hsa041500.58916359
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57712477
97Ras signaling pathway_Homo sapiens_hsa040140.55233512
98Bile secretion_Homo sapiens_hsa049760.55063004
99Homologous recombination_Homo sapiens_hsa034400.53691294
100Glucagon signaling pathway_Homo sapiens_hsa049220.52349449
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.51966914
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51822269
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51142579
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50056782
105Endometrial cancer_Homo sapiens_hsa052130.49986201
106Platelet activation_Homo sapiens_hsa046110.49427293
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49030770
108Sphingolipid metabolism_Homo sapiens_hsa006000.48882161
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48659796
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.47717999
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46526234
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46374753
113Alzheimers disease_Homo sapiens_hsa050100.45842206
114Ovarian steroidogenesis_Homo sapiens_hsa049130.44309834
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43538763
116Endocytosis_Homo sapiens_hsa041440.43043201
117Circadian rhythm_Homo sapiens_hsa047100.42599585
118Prion diseases_Homo sapiens_hsa050200.41797392
119Inositol phosphate metabolism_Homo sapiens_hsa005620.40478250
120African trypanosomiasis_Homo sapiens_hsa051430.40337488
121Retinol metabolism_Homo sapiens_hsa008300.40010650
122Vibrio cholerae infection_Homo sapiens_hsa051100.38289835
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37863628
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37700521
125Renal cell carcinoma_Homo sapiens_hsa052110.37396193
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36935169
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36784787
128Thyroid cancer_Homo sapiens_hsa052160.36130801
129Insulin signaling pathway_Homo sapiens_hsa049100.35674889
130Histidine metabolism_Homo sapiens_hsa003400.34570298
131Regulation of autophagy_Homo sapiens_hsa041400.34098044
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.32552848
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32377421
134Huntingtons disease_Homo sapiens_hsa050160.31968250
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29804697
136Butanoate metabolism_Homo sapiens_hsa006500.28609061
137Arginine biosynthesis_Homo sapiens_hsa002200.27265400
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24442267
139Wnt signaling pathway_Homo sapiens_hsa043100.23589708

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