PDE11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)9.12600582
2melanin metabolic process (GO:0006582)6.84871528
3behavioral response to nicotine (GO:0035095)6.22013881
4melanin biosynthetic process (GO:0042438)6.13861725
5N-acetylneuraminate metabolic process (GO:0006054)6.08074723
6amino sugar catabolic process (GO:0046348)5.86466166
7secondary metabolite biosynthetic process (GO:0044550)5.35846948
8short-term memory (GO:0007614)5.27050121
9facial nerve structural organization (GO:0021612)4.65376400
10presynaptic membrane assembly (GO:0097105)4.43024763
11neuronal action potential propagation (GO:0019227)4.42109129
12indolalkylamine metabolic process (GO:0006586)4.31323140
13postsynaptic membrane organization (GO:0001941)4.31021631
14tryptophan catabolic process (GO:0006569)4.25849840
15indole-containing compound catabolic process (GO:0042436)4.25849840
16indolalkylamine catabolic process (GO:0046218)4.25849840
17cranial nerve morphogenesis (GO:0021602)4.24006170
18kynurenine metabolic process (GO:0070189)4.18471939
19bone trabecula formation (GO:0060346)4.03252574
20negative regulation of heart rate (GO:0010459)4.02517293
21water-soluble vitamin biosynthetic process (GO:0042364)3.82948350
22DNA deamination (GO:0045006)3.79029900
23righting reflex (GO:0060013)3.78034471
24proteasome assembly (GO:0043248)3.76575733
25cranial nerve structural organization (GO:0021604)3.75308730
26piRNA metabolic process (GO:0034587)3.74498419
27arginine catabolic process (GO:0006527)3.73917738
28presynaptic membrane organization (GO:0097090)3.73900571
29sulfation (GO:0051923)3.73823904
30gamma-aminobutyric acid transport (GO:0015812)3.65381653
31negative regulation of cytosolic calcium ion concentration (GO:0051481)3.61530832
32tryptophan metabolic process (GO:0006568)3.58976575
33negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.58935147
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.58111040
35fucose catabolic process (GO:0019317)3.57072662
36L-fucose metabolic process (GO:0042354)3.57072662
37L-fucose catabolic process (GO:0042355)3.57072662
38positive regulation of dendritic spine morphogenesis (GO:0061003)3.55954762
39mesenchymal cell differentiation involved in kidney development (GO:0072161)3.55351423
40mesenchymal cell differentiation involved in renal system development (GO:2001012)3.55351423
41N-acetylglucosamine metabolic process (GO:0006044)3.54345212
42positive regulation of cell cycle G2/M phase transition (GO:1902751)3.45275284
43positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.45275284
44cellular ketone body metabolic process (GO:0046950)3.42696278
45DNA ligation (GO:0006266)3.42170444
46response to folic acid (GO:0051593)3.41859654
47androgen biosynthetic process (GO:0006702)3.39253945
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38488753
49indole-containing compound metabolic process (GO:0042430)3.35883401
50viral transcription (GO:0019083)3.35807954
51regulation of pigment cell differentiation (GO:0050932)3.35488859
52response to pheromone (GO:0019236)3.35436572
53detection of light stimulus involved in visual perception (GO:0050908)3.29580803
54detection of light stimulus involved in sensory perception (GO:0050962)3.29580803
55protein localization to synapse (GO:0035418)3.28821051
56positive regulation of dendritic spine development (GO:0060999)3.28312582
57cellular biogenic amine catabolic process (GO:0042402)3.28093743
58amine catabolic process (GO:0009310)3.28093743
59primary amino compound metabolic process (GO:1901160)3.27975860
60positive regulation of synaptic transmission, GABAergic (GO:0032230)3.25351737
61positive regulation of protein homodimerization activity (GO:0090073)3.22305708
62ionotropic glutamate receptor signaling pathway (GO:0035235)3.21156193
63negative regulation of calcium ion transport into cytosol (GO:0010523)3.20768724
64behavioral response to ethanol (GO:0048149)3.19522448
65GMP metabolic process (GO:0046037)3.19486563
66developmental pigmentation (GO:0048066)3.19305512
67lymphoid progenitor cell differentiation (GO:0002320)3.18898536
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16009972
69neuron cell-cell adhesion (GO:0007158)3.14826353
70regulation of timing of cell differentiation (GO:0048505)3.14727091
71ketone body metabolic process (GO:1902224)3.13007309
72nephron tubule formation (GO:0072079)3.11996609
73negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.11784297
74translational termination (GO:0006415)3.11452708
75regulation of development, heterochronic (GO:0040034)3.11357730
76superoxide anion generation (GO:0042554)3.11164839
77forebrain neuron development (GO:0021884)3.10748929
78mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.10349868
79cell proliferation in forebrain (GO:0021846)3.08376115
80negative regulation of leukocyte chemotaxis (GO:0002689)3.07696725
81cellular response to ATP (GO:0071318)3.07683987
82protein polyglutamylation (GO:0018095)3.07341891
83central nervous system neuron axonogenesis (GO:0021955)3.06556493
84serotonin metabolic process (GO:0042428)3.04421978
85axoneme assembly (GO:0035082)3.03094040
86mesonephros development (GO:0001823)3.02295714
87negative regulation of transcription regulatory region DNA binding (GO:2000678)3.01855203
88protein heterotetramerization (GO:0051290)3.01200612
89viral genome replication (GO:0019079)3.00858328
90generation of neurons (GO:0048699)3.00004015
91peptidyl-arginine omega-N-methylation (GO:0035247)2.95508908
92centriole assembly (GO:0098534)2.93697397
93vocalization behavior (GO:0071625)2.90078588
94positive regulation of synapse assembly (GO:0051965)2.89517348
95dopamine transport (GO:0015872)2.87841860
96reflex (GO:0060004)2.86891651
97response to water (GO:0009415)2.86820277
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85008304
99positive regulation of cAMP-mediated signaling (GO:0043950)2.82288893
100transmission of nerve impulse (GO:0019226)2.81785172
101neuronal action potential (GO:0019228)2.79926482
102sympathetic nervous system development (GO:0048485)2.78053604
103glucosamine-containing compound metabolic process (GO:1901071)2.77300814
104cytochrome complex assembly (GO:0017004)2.75886394
105protein complex biogenesis (GO:0070271)2.75741676
106negative regulation of appetite (GO:0032099)2.75123355
107negative regulation of response to food (GO:0032096)2.75123355
108regulation of rhodopsin mediated signaling pathway (GO:0022400)2.73841290
109respiratory chain complex IV assembly (GO:0008535)2.73388545
110positive regulation of hair follicle development (GO:0051798)2.72741391
111positive regulation of hair cycle (GO:0042635)2.72741391
112regulation of mesoderm development (GO:2000380)2.72364515
113ribosomal large subunit biogenesis (GO:0042273)2.72350644
114serotonin receptor signaling pathway (GO:0007210)2.72031599
115embryonic epithelial tube formation (GO:0001838)2.71443367
116cornea development in camera-type eye (GO:0061303)2.71195592
117regulation of action potential (GO:0098900)2.71060052
118positive regulation of membrane potential (GO:0045838)2.70772012
119response to muscle activity (GO:0014850)2.70592419
120cell differentiation involved in metanephros development (GO:0072202)2.69392108
121multicellular organism reproduction (GO:0032504)2.69332084
122regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.67938045
123synaptic transmission, cholinergic (GO:0007271)2.67885335
124negative regulation of systemic arterial blood pressure (GO:0003085)2.67769778
125somite development (GO:0061053)2.66558446
126positive regulation of fatty acid oxidation (GO:0046321)2.65702256
127mitochondrial respiratory chain complex I assembly (GO:0032981)2.65117774
128NADH dehydrogenase complex assembly (GO:0010257)2.65117774
129mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65117774
130protein localization to cilium (GO:0061512)2.64637712
131opioid receptor signaling pathway (GO:0038003)2.64635646
132enteric nervous system development (GO:0048484)2.63617373
133DNA methylation involved in gamete generation (GO:0043046)2.63533719
134rhodopsin mediated signaling pathway (GO:0016056)2.63487518
135pattern specification involved in kidney development (GO:0061004)2.61799533
136epithelial cilium movement (GO:0003351)2.61525257
137membrane depolarization during action potential (GO:0086010)2.60752595
138regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.60300262
139SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.59649611
140epithelial tube formation (GO:0072175)2.58926890
141phosphatidylinositol acyl-chain remodeling (GO:0036149)2.58648210
142drug catabolic process (GO:0042737)2.58215352
143glutamate receptor signaling pathway (GO:0007215)2.57857974
144kidney morphogenesis (GO:0060993)2.57799697
145cotranslational protein targeting to membrane (GO:0006613)2.57731259
146aromatic amino acid family catabolic process (GO:0009074)2.57335233
147regulation of synaptic transmission, GABAergic (GO:0032228)2.56533269
148spinal cord motor neuron differentiation (GO:0021522)2.56195618
149regulation of acrosome reaction (GO:0060046)2.55896191
150photoreceptor cell maintenance (GO:0045494)2.55436105
151protein targeting to ER (GO:0045047)2.54351355
152negative regulation of mast cell activation (GO:0033004)2.54184418
153regulation of neurotransmitter uptake (GO:0051580)2.54164568
154detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.53253291
155G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51894295
156mitochondrial respiratory chain complex assembly (GO:0033108)2.51344945
157cytidine deamination (GO:0009972)2.51296062
158cytidine metabolic process (GO:0046087)2.51296062
159cytidine catabolic process (GO:0006216)2.51296062
160adaptation of signaling pathway (GO:0023058)2.51292431
161regulation of relaxation of muscle (GO:1901077)2.50195702
162positive regulation of protein kinase C signaling (GO:0090037)2.48963539
163phenol-containing compound biosynthetic process (GO:0046189)2.48837535
164benzene-containing compound metabolic process (GO:0042537)2.48750386
165photoreceptor cell development (GO:0042461)2.48381930
166thyroid hormone metabolic process (GO:0042403)2.47637325
167positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.47600790
168platelet dense granule organization (GO:0060155)2.46423792
169regulation of cell communication by electrical coupling (GO:0010649)2.46095395
170oxidative demethylation (GO:0070989)2.45927616
171nonmotile primary cilium assembly (GO:0035058)2.45015450
172exogenous drug catabolic process (GO:0042738)2.41776364
173secondary metabolic process (GO:0019748)2.41640044
174peptidyl-arginine methylation (GO:0018216)2.41525505
175peptidyl-arginine N-methylation (GO:0035246)2.41525505
176positive regulation of meiosis (GO:0045836)2.39716026
177establishment of protein localization to endoplasmic reticulum (GO:0072599)2.39150761
178parturition (GO:0007567)2.38866865
179detection of mechanical stimulus involved in sensory perception (GO:0050974)2.38728490
180regulation of sequestering of triglyceride (GO:0010889)2.38243901
1813-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.38164163
182purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.38164163
183adult feeding behavior (GO:0008343)2.38150254
184aromatic amino acid family metabolic process (GO:0009072)2.38047958
185RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.37955199
186positive regulation of fatty acid transport (GO:2000193)2.37918985
187neural tube formation (GO:0001841)2.37766432
188neuromuscular synaptic transmission (GO:0007274)2.37699733
189protein localization to endoplasmic reticulum (GO:0070972)2.36287484
190preassembly of GPI anchor in ER membrane (GO:0016254)2.36176506
191regulation of hippo signaling (GO:0035330)2.35879250
192protein neddylation (GO:0045116)2.35598610
193retinal cone cell development (GO:0046549)2.34763211
194positive regulation of fatty acid beta-oxidation (GO:0032000)2.34469847
195glyoxylate metabolic process (GO:0046487)2.33973802
196negative regulation of telomere maintenance (GO:0032205)2.32616754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.96784869
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.95727344
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.98319972
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.31624087
5ZNF274_21170338_ChIP-Seq_K562_Hela3.25412604
6* GBX2_23144817_ChIP-Seq_PC3_Human3.09938492
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77664416
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.71565507
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69581154
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67651940
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67651940
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63615192
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.60730039
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.55044897
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47148167
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.41666636
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41426150
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40464556
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39226036
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.17294950
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.15726498
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07691855
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06941695
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.04618923
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00107675
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99236120
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.94662568
28FUS_26573619_Chip-Seq_HEK293_Human1.91236374
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85477947
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.84448215
31EWS_26573619_Chip-Seq_HEK293_Human1.83745274
32TAF15_26573619_Chip-Seq_HEK293_Human1.83065859
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.82868859
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81513055
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.80098683
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79433944
37* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77969258
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77893006
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72094603
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.71550459
41AR_21572438_ChIP-Seq_LNCaP_Human1.69123325
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65814264
43* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60858328
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.60366302
45CBP_20019798_ChIP-Seq_JUKART_Human1.58144910
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58144910
47RNF2_27304074_Chip-Seq_NSC_Mouse1.55864229
48BCAT_22108803_ChIP-Seq_LS180_Human1.54513021
49* STAT3_23295773_ChIP-Seq_U87_Human1.51533502
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.51306984
51* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50689442
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.50611965
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49610442
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49610442
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48703263
56IRF1_19129219_ChIP-ChIP_H3396_Human1.48370688
57* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46015547
58* TCF4_23295773_ChIP-Seq_U87_Human1.45590247
59* P53_22387025_ChIP-Seq_ESCs_Mouse1.43094646
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39497890
61* NANOG_18555785_Chip-Seq_ESCs_Mouse1.38922470
62P300_19829295_ChIP-Seq_ESCs_Human1.37626112
63NANOG_19829295_ChIP-Seq_ESCs_Human1.37419955
64SOX2_19829295_ChIP-Seq_ESCs_Human1.37419955
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35585662
66* RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35545628
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35439052
68* E2F1_18555785_Chip-Seq_ESCs_Mouse1.35290914
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35119430
70* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34439798
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32724551
72* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31835619
73TP53_22573176_ChIP-Seq_HFKS_Human1.31641099
74* NMYC_18555785_Chip-Seq_ESCs_Mouse1.30916869
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30032766
76TCF4_22108803_ChIP-Seq_LS180_Human1.29990139
77* P300_18555785_Chip-Seq_ESCs_Mouse1.29722970
78SMAD4_21799915_ChIP-Seq_A2780_Human1.29100191
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28714229
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28495663
81TP53_20018659_ChIP-ChIP_R1E_Mouse1.27379929
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.27318205
83* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.27191219
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.26364208
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25479694
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25435803
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24967687
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.24029064
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.23440759
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22485082
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21959517
92ER_23166858_ChIP-Seq_MCF-7_Human1.21586322
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.21065489
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.20224559
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18867038
96* STAT3_18555785_Chip-Seq_ESCs_Mouse1.18828154
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.18265008
98CDX2_20551321_ChIP-Seq_CACO-2_Human1.18149482
99FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17527280
100FOXA1_25329375_ChIP-Seq_VCAP_Human1.17527280
101* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17190195
102NCOR_22424771_ChIP-Seq_293T_Human1.15811949
103REST_21632747_ChIP-Seq_MESCs_Mouse1.15510604
104* SOX2_18555785_Chip-Seq_ESCs_Mouse1.14205324
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13214260
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12814508
107* CTCF_18555785_Chip-Seq_ESCs_Mouse1.12710658
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11460581
109OCT4_18555785_Chip-Seq_ESCs_Mouse1.11275486
110GATA3_21878914_ChIP-Seq_MCF-7_Human1.11135594
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11118449
112AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10721363
113ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10020978
114POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09902913
115RING1B_27294783_Chip-Seq_NPCs_Mouse1.09534006
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09434214
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08703748
118KLF4_18555785_Chip-Seq_ESCs_Mouse1.08659271
119ZFX_18555785_Chip-Seq_ESCs_Mouse1.08605267
120PU1_27457419_Chip-Seq_LIVER_Mouse1.08324927
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07809354
122RING1B_27294783_Chip-Seq_ESCs_Mouse1.07692580
123LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05491616
124CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04893832
125CDX2_22108803_ChIP-Seq_LS180_Human1.04578596
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04565593
127TP53_18474530_ChIP-ChIP_U2OS_Human1.04243314
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03812701
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03750056
130WT1_19549856_ChIP-ChIP_CCG9911_Human1.02573186
131KDM2B_26808549_Chip-Seq_REH_Human1.02212038
132EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01317620
133EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00496052
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99990410
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99424391
136FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99345293
137* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99200092
138FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98789061
139VDR_22108803_ChIP-Seq_LS180_Human0.98215534
140LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95317141
141SMAD1_18555785_Chip-Seq_ESCs_Mouse0.94910537
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.94564835
143TAL1_26923725_Chip-Seq_HPCs_Mouse0.94038576
144MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92489106
145DROSHA_22980978_ChIP-Seq_HELA_Human0.92049255
146AR_25329375_ChIP-Seq_VCAP_Human0.91896931
147* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91558315
148SMAD3_21741376_ChIP-Seq_HESCs_Human0.90429763
149IGF1R_20145208_ChIP-Seq_DFB_Human0.90222382
150* RUNX2_22187159_ChIP-Seq_PCA_Human0.89807653

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.61334329
2MP0000372_irregular_coat_pigmentation4.37644214
3MP0001188_hyperpigmentation4.17747466
4MP0005409_darkened_coat_color3.91796208
5MP0009379_abnormal_foot_pigmentation3.69731443
6MP0002102_abnormal_ear_morphology3.23168405
7MP0004381_abnormal_hair_follicle3.22778605
8MP0003195_calcinosis3.16350398
9MP0005171_absent_coat_pigmentation3.15266785
10MP0003880_abnormal_central_pattern2.99905131
11MP0002837_dystrophic_cardiac_calcinosis2.91097522
12MP0006292_abnormal_olfactory_placode2.80219274
13MP0004145_abnormal_muscle_electrophysio2.68979720
14MP0000015_abnormal_ear_pigmentation2.62433847
15MP0001986_abnormal_taste_sensitivity2.57458055
16MP0005646_abnormal_pituitary_gland2.56067674
17MP0001968_abnormal_touch/_nociception2.51247727
18MP0005174_abnormal_tail_pigmentation2.30103581
19MP0008260_abnormal_autophagy2.17932843
20MP0002876_abnormal_thyroid_physiology2.12499419
21MP0002735_abnormal_chemical_nociception2.04906241
22MP0002736_abnormal_nociception_after2.04020659
23MP0008877_abnormal_DNA_methylation2.00616593
24MP0005257_abnormal_intraocular_pressure1.98103797
25MP0001485_abnormal_pinna_reflex1.95410985
26MP0003315_abnormal_perineum_morphology1.88447581
27MP0000569_abnormal_digit_pigmentation1.82652552
28MP0006276_abnormal_autonomic_nervous1.81747114
29MP0008872_abnormal_physiological_respon1.78033146
30MP0002095_abnormal_skin_pigmentation1.75258160
31MP0004885_abnormal_endolymph1.74274035
32MP0004142_abnormal_muscle_tone1.65479161
33MP0002067_abnormal_sensory_capabilities1.64086986
34MP0002138_abnormal_hepatobiliary_system1.59810159
35MP0005408_hypopigmentation1.58771067
36MP0004130_abnormal_muscle_cell1.57949377
37MP0002638_abnormal_pupillary_reflex1.49766012
38MP0003724_increased_susceptibility_to1.47692051
39MP0001486_abnormal_startle_reflex1.47444720
40MP0002249_abnormal_larynx_morphology1.47336514
41MP0003011_delayed_dark_adaptation1.45333889
42MP0004043_abnormal_pH_regulation1.42756831
43MP0002177_abnormal_outer_ear1.42528067
44MP0004742_abnormal_vestibular_system1.38271754
45MP0004215_abnormal_myocardial_fiber1.37017687
46MP0002751_abnormal_autonomic_nervous1.36878245
47MP0005075_abnormal_melanosome_morpholog1.36584973
48MP0000566_synostosis1.33082444
49MP0002653_abnormal_ependyma_morphology1.32982501
50MP0002734_abnormal_mechanical_nocicepti1.32100022
51MP0002277_abnormal_respiratory_mucosa1.31893454
52MP0008875_abnormal_xenobiotic_pharmacok1.31389217
53MP0005670_abnormal_white_adipose1.31202500
54MP0003646_muscle_fatigue1.28888208
55MP0001970_abnormal_pain_threshold1.26845857
56MP0004133_heterotaxia1.26599122
57MP0000681_abnormal_thyroid_gland1.26399878
58MP0008789_abnormal_olfactory_epithelium1.24763139
59MP0002938_white_spotting1.24312040
60MP0003938_abnormal_ear_development1.24283458
61MP0004147_increased_porphyrin_level1.24040676
62MP0002272_abnormal_nervous_system1.22792268
63MP0003635_abnormal_synaptic_transmissio1.20709971
64MP0005389_reproductive_system_phenotype1.20561526
65MP0000026_abnormal_inner_ear1.20298283
66* MP0009745_abnormal_behavioral_response1.19355414
67MP0002064_seizures1.19220388
68MP0002184_abnormal_innervation1.18513433
69MP0008775_abnormal_heart_ventricle1.18431739
70MP0000049_abnormal_middle_ear1.15944886
71MP0005084_abnormal_gallbladder_morpholo1.15047689
72* MP0002557_abnormal_social/conspecific_i1.13783576
73MP0002733_abnormal_thermal_nociception1.10573139
74MP0004859_abnormal_synaptic_plasticity1.09579351
75MP0005360_urolithiasis1.08135141
76MP0000230_abnormal_systemic_arterial1.07749837
77MP0005394_taste/olfaction_phenotype1.07177366
78MP0005499_abnormal_olfactory_system1.07177366
79MP0009046_muscle_twitch1.03948977
80MP0003787_abnormal_imprinting1.03255969
81MP0002572_abnormal_emotion/affect_behav1.01994263
82MP0000778_abnormal_nervous_system1.01771046
83MP0005085_abnormal_gallbladder_physiolo1.01437672
84MP0001919_abnormal_reproductive_system0.99488510
85MP0005410_abnormal_fertilization0.98478088
86MP0005195_abnormal_posterior_eye0.98035248
87MP0009250_abnormal_appendicular_skeleto0.94950567
88MP0000427_abnormal_hair_cycle0.94886645
89MP0005167_abnormal_blood-brain_barrier0.94808468
90MP0002752_abnormal_somatic_nervous0.94406493
91MP0003137_abnormal_impulse_conducting0.93916421
92MP0005165_increased_susceptibility_to0.93685906
93MP0000613_abnormal_salivary_gland0.93666487
94MP0002160_abnormal_reproductive_system0.92218620
95MP0002928_abnormal_bile_duct0.91478147
96MP0001501_abnormal_sleep_pattern0.91298290
97MP0001963_abnormal_hearing_physiology0.90534728
98MP0001502_abnormal_circadian_rhythm0.90405128
99MP0005332_abnormal_amino_acid0.88715201
100MP0005386_behavior/neurological_phenoty0.88383111
101MP0004924_abnormal_behavior0.88383111
102MP0001663_abnormal_digestive_system0.88049076
103MP0000678_abnormal_parathyroid_gland0.87955489
104MP0001984_abnormal_olfaction0.87565615
105MP0010386_abnormal_urinary_bladder0.86283621
106MP0009780_abnormal_chondrocyte_physiolo0.85913464
107MP0008995_early_reproductive_senescence0.85464157
108MP0002234_abnormal_pharynx_morphology0.85042971
109MP0001186_pigmentation_phenotype0.84962261
110MP0000631_abnormal_neuroendocrine_gland0.84760428
111MP0003385_abnormal_body_wall0.84429329
112MP0008569_lethality_at_weaning0.84222666
113MP0003937_abnormal_limbs/digits/tail_de0.84043080
114MP0006072_abnormal_retinal_apoptosis0.82697821
115MP0003638_abnormal_response/metabolism_0.82274792
116MP0002075_abnormal_coat/hair_pigmentati0.82011821
117MP0003252_abnormal_bile_duct0.81322581
118MP0000371_diluted_coat_color0.81208550
119MP0004085_abnormal_heartbeat0.81208430
120MP0009764_decreased_sensitivity_to0.80082153
121MP0010329_abnormal_lipoprotein_level0.77813020
122MP0002229_neurodegeneration0.77678332
123MP0004134_abnormal_chest_morphology0.77203222
124MP0000579_abnormal_nail_morphology0.77072848
125MP0001664_abnormal_digestion0.76794778
126MP0002163_abnormal_gland_morphology0.76254795
127MP0005379_endocrine/exocrine_gland_phen0.76172558
128MP0001440_abnormal_grooming_behavior0.75595004
129MP0001905_abnormal_dopamine_level0.74789802
130MP0005377_hearing/vestibular/ear_phenot0.74319306
131MP0003878_abnormal_ear_physiology0.74319306
132MP0002148_abnormal_hypersensitivity_rea0.73963990
133MP0005551_abnormal_eye_electrophysiolog0.72410743
134MP0002063_abnormal_learning/memory/cond0.71338993
135MP0002882_abnormal_neuron_morphology0.70784886
136MP0003718_maternal_effect0.68519913
137MP0003303_peritoneal_inflammation0.67894949
138MP0005645_abnormal_hypothalamus_physiol0.67131330
139MP0004270_analgesia0.65669660
140MP0009785_altered_susceptibility_to0.61150076
141MP0005253_abnormal_eye_physiology0.59635920
142MP0003786_premature_aging0.59367587
143MP0005381_digestive/alimentary_phenotyp0.58099536
144MP0001324_abnormal_eye_pigmentation0.57588017
145MP0003879_abnormal_hair_cell0.57463487
146MP0000955_abnormal_spinal_cord0.57386414

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.52538491
2Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.37042605
3Pancreatic fibrosis (HP:0100732)4.21113331
4Hypoplasia of the fovea (HP:0007750)4.06517918
5Aplasia/Hypoplasia of the fovea (HP:0008060)4.06517918
6Reduced antithrombin III activity (HP:0001976)4.01899279
7True hermaphroditism (HP:0010459)3.99865872
8Type I transferrin isoform profile (HP:0003642)3.99122191
9Split foot (HP:0001839)3.98917912
10Focal motor seizures (HP:0011153)3.92816154
11Congenital stationary night blindness (HP:0007642)3.91418943
12Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.62903432
13Abnormality of midbrain morphology (HP:0002418)3.61902005
14Molar tooth sign on MRI (HP:0002419)3.61902005
15Increased hepatocellular lipid droplets (HP:0006565)3.55922140
16Nephronophthisis (HP:0000090)3.54474802
17Severe visual impairment (HP:0001141)3.47887479
18Abolished electroretinogram (ERG) (HP:0000550)3.44497713
193-Methylglutaconic aciduria (HP:0003535)3.38726022
20Pendular nystagmus (HP:0012043)3.37339916
21Abnormality of the renal cortex (HP:0011035)3.31211719
22Dry hair (HP:0011359)3.29837916
23Abnormality of the fovea (HP:0000493)3.25826242
24Testicular atrophy (HP:0000029)3.20095484
25Optic disc pallor (HP:0000543)3.18098168
26Renal Fanconi syndrome (HP:0001994)3.15687522
27Abnormality of the renal medulla (HP:0100957)3.09278046
28Hypothermia (HP:0002045)3.06253465
29Aplasia/Hypoplasia of the macula (HP:0008059)3.06227646
30Nonprogressive disorder (HP:0003680)3.06031305
31Type II lissencephaly (HP:0007260)2.98396354
32Keratoconus (HP:0000563)2.92254745
33Increased corneal curvature (HP:0100692)2.92254745
34Progressive external ophthalmoplegia (HP:0000590)2.89947688
35Febrile seizures (HP:0002373)2.85390003
36Lipid accumulation in hepatocytes (HP:0006561)2.80042298
37Horizontal nystagmus (HP:0000666)2.76787529
38Abnormality of magnesium homeostasis (HP:0004921)2.72848847
39Attenuation of retinal blood vessels (HP:0007843)2.72659910
40Mitochondrial inheritance (HP:0001427)2.72480197
41Decreased central vision (HP:0007663)2.70704797
42Abnormal rod and cone electroretinograms (HP:0008323)2.70428544
43Cystic liver disease (HP:0006706)2.68589681
44Congenital, generalized hypertrichosis (HP:0004540)2.66406024
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.65635456
46Tubular atrophy (HP:0000092)2.64664869
47Congenital sensorineural hearing impairment (HP:0008527)2.63641032
48Microvesicular hepatic steatosis (HP:0001414)2.62275915
49Renal cortical cysts (HP:0000803)2.61012298
50Concave nail (HP:0001598)2.58571511
51Genetic anticipation (HP:0003743)2.56587025
52Ocular albinism (HP:0001107)2.55676041
53Sex reversal (HP:0012245)2.55538115
54Abnormal sex determination (HP:0012244)2.55538115
55Decreased circulating renin level (HP:0003351)2.55442051
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.54770374
57Progressive cerebellar ataxia (HP:0002073)2.54242026
58Blue irides (HP:0000635)2.53041107
59Acute necrotizing encephalopathy (HP:0006965)2.52897472
60Hypomagnesemia (HP:0002917)2.52023123
61Aplasia/Hypoplasia affecting the retina (HP:0008061)2.51768913
62Aplasia/Hypoplasia of the spleen (HP:0010451)2.50977118
63Gaze-evoked nystagmus (HP:0000640)2.49902184
64Hepatocellular necrosis (HP:0001404)2.48611043
65Hyperventilation (HP:0002883)2.48305806
66Exertional dyspnea (HP:0002875)2.46857838
67Chronic hepatic failure (HP:0100626)2.46601411
68Thyroid-stimulating hormone excess (HP:0002925)2.46428716
69Asplenia (HP:0001746)2.45944252
70Medial flaring of the eyebrow (HP:0010747)2.44709047
71Sensory axonal neuropathy (HP:0003390)2.44382361
72Sclerocornea (HP:0000647)2.44139187
73Abnormality of the phalanges of the hallux (HP:0010057)2.41183317
74Methylmalonic acidemia (HP:0002912)2.40005206
75Polydipsia (HP:0001959)2.39323100
76Abnormal drinking behavior (HP:0030082)2.39323100
77Iris hypopigmentation (HP:0007730)2.36481619
78Inability to walk (HP:0002540)2.36468888
79Stage 5 chronic kidney disease (HP:0003774)2.32486022
80Oligodactyly (hands) (HP:0001180)2.29580200
81Abnormality of alanine metabolism (HP:0010916)2.29088750
82Hyperalaninemia (HP:0003348)2.29088750
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29088750
84Abnormality of calcium-phosphate metabolism (HP:0100530)2.28893509
85Hyperphosphaturia (HP:0003109)2.27104514
86Furrowed tongue (HP:0000221)2.25823758
87Abnormal urine phosphate concentration (HP:0012599)2.25816028
88Abnormal protein glycosylation (HP:0012346)2.22669652
89Abnormal glycosylation (HP:0012345)2.22669652
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22669652
91Abnormal protein N-linked glycosylation (HP:0012347)2.22669652
92Abnormality of the axillary hair (HP:0100134)2.21627030
93Abnormality of secondary sexual hair (HP:0009888)2.21627030
94Aplasia/Hypoplasia of the tongue (HP:0010295)2.20276409
95Large for gestational age (HP:0001520)2.19508022
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19453939
97Obstructive lung disease (HP:0006536)2.18606903
98Chronic obstructive pulmonary disease (HP:0006510)2.18606903
99Chorioretinal atrophy (HP:0000533)2.17898370
100Basal ganglia calcification (HP:0002135)2.17426392
101Methylmalonic aciduria (HP:0012120)2.17189596
102Short tibia (HP:0005736)2.15545894
103Capillary hemangiomas (HP:0005306)2.15477365
104Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15258910
105Progressive macrocephaly (HP:0004481)2.14902265
106Male pseudohermaphroditism (HP:0000037)2.14632774
107Hyperglycinemia (HP:0002154)2.13087588
108Abnormal hemoglobin (HP:0011902)2.10885588
109Impaired proprioception (HP:0010831)2.10562425
110Anencephaly (HP:0002323)2.10219781
111Renal tubular dysfunction (HP:0000124)2.09792185
112Abnormality of the renal collecting system (HP:0004742)2.07740763
113Dyschromatopsia (HP:0007641)2.07681786
114Meningitis (HP:0001287)2.06993210
115Patchy hypopigmentation of hair (HP:0011365)2.04928542
116Ulnar claw (HP:0001178)2.04820421
117Aplasia/hypoplasia of the uterus (HP:0008684)2.04210471
118Progressive inability to walk (HP:0002505)2.04087783
119Aplasia/Hypoplasia of the tibia (HP:0005772)2.03457879
120Hypoplasia of the uterus (HP:0000013)2.03343373
121Clumsiness (HP:0002312)2.02917966
122Congenital hepatic fibrosis (HP:0002612)2.02370370
123Abnormality of renal resorption (HP:0011038)2.01642582
124Increased CSF lactate (HP:0002490)2.00847904
125Bony spicule pigmentary retinopathy (HP:0007737)1.99862640
126Reticulocytopenia (HP:0001896)1.99341990
127Abnormal biliary tract physiology (HP:0012439)1.99011284
128Bile duct proliferation (HP:0001408)1.99011284
129White forelock (HP:0002211)1.98839960
130Stomatitis (HP:0010280)1.98248756
131Oligodactyly (HP:0012165)1.96842160
132Broad-based gait (HP:0002136)1.94323537
133Abnormal mitochondria in muscle tissue (HP:0008316)1.93555474
134Abnormality of pyrimidine metabolism (HP:0004353)1.93513825
135Lower limb hyperreflexia (HP:0002395)1.93336189
136Intestinal atresia (HP:0011100)1.92644999
137Postaxial foot polydactyly (HP:0001830)1.92602807
138Abnormal hair laboratory examination (HP:0003328)1.91736010
139Polyuria (HP:0000103)1.91304244
140Absent/shortened dynein arms (HP:0200106)1.90683460
141Dynein arm defect of respiratory motile cilia (HP:0012255)1.90683460
142Recurrent cutaneous fungal infections (HP:0011370)1.90291417
143Chronic mucocutaneous candidiasis (HP:0002728)1.90291417
144Abnormality of the phalanges of the 2nd finger (HP:0009541)1.90288664
145Optic nerve hypoplasia (HP:0000609)1.87458566
146Cerebellar dysplasia (HP:0007033)1.84382593
147Gait imbalance (HP:0002141)1.84134990
148Absent septum pellucidum (HP:0001331)1.83067389
149Increased intramyocellular lipid droplets (HP:0012240)1.82843160
150Hemiparesis (HP:0001269)1.82546485
151Myokymia (HP:0002411)1.80603631
152Lissencephaly (HP:0001339)1.80527541
153Abnormal respiratory motile cilium morphology (HP:0005938)1.80285796
154Abnormal respiratory epithelium morphology (HP:0012253)1.80285796
155Abnormality of the septum pellucidum (HP:0007375)1.80093090
156Macrocytic anemia (HP:0001972)1.79793958
157Ketosis (HP:0001946)1.78550048
158Congenital primary aphakia (HP:0007707)1.78081397
159Midline defect of the nose (HP:0004122)1.77936899
160Severe muscular hypotonia (HP:0006829)1.77878591
161Hypophosphatemic rickets (HP:0004912)1.77626551
162Supernumerary spleens (HP:0009799)1.77608342
163Aplasia cutis congenita (HP:0001057)1.76901784
164Triphalangeal thumb (HP:0001199)1.75103067
165Renal dysplasia (HP:0000110)1.74037643
166Small hand (HP:0200055)1.73657440
167Acute encephalopathy (HP:0006846)1.73053135
168Abnormality of macular pigmentation (HP:0008002)1.72727773
169Genital tract atresia (HP:0001827)1.72264209
170Tachypnea (HP:0002789)1.68932307
171Focal seizures (HP:0007359)1.66587615
172Ketoacidosis (HP:0001993)1.66172093
173Aplasia/Hypoplasia of the patella (HP:0006498)1.65883150
174Hypoplasia of the pons (HP:0012110)1.65712362
175Abnormal ciliary motility (HP:0012262)1.65017726
176Duplicated collecting system (HP:0000081)1.64924193
177Fair hair (HP:0002286)1.64303646
178Hypoproteinemia (HP:0003075)1.63973730

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.33828596
2FRK6.22482144
3TLK15.47530039
4MKNK24.47814499
5NME24.45403436
6MAPK132.85411527
7TAOK32.80809945
8TNIK2.70050265
9MKNK12.61277575
10MAP4K22.35043482
11WNK32.33882180
12FES2.32617546
13MUSK2.30258023
14IRAK32.18055888
15INSRR2.17278776
16ZAK2.13550706
17SRPK12.05596410
18WNK42.04000823
19NUAK11.96466783
20MAP3K41.88089872
21OBSCN1.86714552
22RIPK41.86228628
23ACVR1B1.78322780
24MAP2K71.71115396
25NTRK31.67891914
26PRKD21.65243062
27PHKG11.55020994
28PHKG21.55020994
29IRAK11.53760720
30GRK51.50632279
31TEC1.45897063
32OXSR11.45274066
33IRAK41.42339381
34IRAK21.41668993
35STK161.40305107
36BLK1.38505574
37NME11.37627241
38TIE11.32018002
39PRPF4B1.28835627
40MST1R1.25331194
41BMPR21.17581190
42MAPK111.16821616
43CDK191.15996667
44MAP3K121.15968474
45YES11.15328223
46MAPK121.15282988
47TXK1.13745717
48BCKDK1.07400028
49STK38L1.04083885
50PNCK1.03237666
51EIF2AK21.01990353
52CAMK10.95027972
53EIF2AK30.93958689
54MAPKAPK30.93820515
55ADRBK20.93133370
56NTRK20.92477833
57TRIM280.86313863
58DYRK20.85380422
59TNK20.84335190
60FER0.81249849
61PAK30.79701582
62CLK10.79024381
63CAMK2B0.79017313
64PIK3CA0.78876019
65GRK10.78574958
66MARK10.76761124
67TGFBR10.75753968
68PIK3CG0.73820431
69PRKCI0.67495330
70CAMK2A0.67450923
71VRK10.64996570
72ITK0.64090942
73FGFR20.63860985
74GRK70.63173417
75STK380.62868443
76DAPK30.61952705
77SYK0.60511139
78CSNK1G10.60327628
79UHMK10.58989932
80FGR0.56937877
81ERBB20.56672199
82MST40.55502406
83PRKG20.54642629
84CSNK1A10.54234722
85EIF2AK10.54079470
86HIPK20.53758548
87CSNK1A1L0.53171685
88VRK20.52368398
89PRKCE0.51832232
90LYN0.50884885
91EPHB20.50742170
92NLK0.50263250
93AKT30.49511515
94ADRBK10.49130913
95EPHA40.48904363
96CSK0.48186282
97RPS6KA50.47313644
98STK110.46679686
99PRKCG0.46180918
100PRKAA20.45955483
101CAMKK20.45804188
102PIM20.45533058
103BTK0.45459525
104MAPK40.44362350
105PLK40.43821992
106GRK60.42962521
107DAPK20.42904475
108PRKCZ0.42828222
109CDK30.42019367
110SIK20.41753729
111KIT0.39359644
112BCR0.39093479
113LCK0.38857187
114CAMK2D0.38678561
115STK390.38369019
116BMPR1B0.37639230
117IGF1R0.37557556
118DYRK1A0.37411367
119CAMK2G0.37132863
120PRKAA10.36956968
121* PRKACA0.36573157
122MARK30.34959535
123SGK10.34707583
124CSNK1G30.34060606
125BRAF0.33924492
126CSNK1D0.32786394
127SGK2230.32064075
128SGK4940.32064075
129PRKACG0.31926715
130PRKG10.31861981
131MAP2K10.31520010
132MAP3K140.31365535
133PKN10.30845571
134PINK10.30256608
135MAP2K40.28842146
136CHUK0.28675427
137CAMK40.28326580
138SGK20.28151750
139MAPKAPK50.27285188
140CDK50.26184628
141PRKCQ0.25297254
142CDK140.24690851
143MAP2K60.24456347
144CDK80.23810790
145IKBKE0.23603519
146PRKCD0.23231185
147CSNK1G20.21387480
148IKBKB0.20640082
149PRKCA0.19676393
150PBK0.19550498
151PLK20.18779502
152PTK2B0.18682684

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.79352552
2Oxidative phosphorylation_Homo sapiens_hsa001903.04612685
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.95135353
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.88425118
5Phototransduction_Homo sapiens_hsa047442.87410358
6Linoleic acid metabolism_Homo sapiens_hsa005912.74270982
7Nicotine addiction_Homo sapiens_hsa050332.51685615
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.46519145
9Nitrogen metabolism_Homo sapiens_hsa009102.41653586
10Butanoate metabolism_Homo sapiens_hsa006502.31232486
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.18403176
12Parkinsons disease_Homo sapiens_hsa050122.12257274
13Tryptophan metabolism_Homo sapiens_hsa003802.11044494
14Caffeine metabolism_Homo sapiens_hsa002322.09673094
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05313298
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.02719695
17Alzheimers disease_Homo sapiens_hsa050102.01445374
18Taste transduction_Homo sapiens_hsa047421.97833075
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90768756
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88089749
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.86464534
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78170214
23RNA polymerase_Homo sapiens_hsa030201.69538564
24Glutamatergic synapse_Homo sapiens_hsa047241.68730027
25Homologous recombination_Homo sapiens_hsa034401.58872761
26Retinol metabolism_Homo sapiens_hsa008301.55747153
27Arachidonic acid metabolism_Homo sapiens_hsa005901.52576325
28Huntingtons disease_Homo sapiens_hsa050161.51843861
29Fanconi anemia pathway_Homo sapiens_hsa034601.51336514
30Selenocompound metabolism_Homo sapiens_hsa004501.49345779
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46538245
32Propanoate metabolism_Homo sapiens_hsa006401.45720542
33Chemical carcinogenesis_Homo sapiens_hsa052041.45279917
34Graft-versus-host disease_Homo sapiens_hsa053321.45234802
35Protein export_Homo sapiens_hsa030601.45027482
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44685523
37Melanogenesis_Homo sapiens_hsa049161.41107198
38Serotonergic synapse_Homo sapiens_hsa047261.39401235
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38032803
40Collecting duct acid secretion_Homo sapiens_hsa049661.37928178
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33856367
42* Morphine addiction_Homo sapiens_hsa050321.30538208
43Long-term depression_Homo sapiens_hsa047301.30253754
44Olfactory transduction_Homo sapiens_hsa047401.29789830
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29200401
46Cardiac muscle contraction_Homo sapiens_hsa042601.26469049
47Synaptic vesicle cycle_Homo sapiens_hsa047211.25733267
48Salivary secretion_Homo sapiens_hsa049701.25245844
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.24627859
50Circadian entrainment_Homo sapiens_hsa047131.22909601
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20317285
52Peroxisome_Homo sapiens_hsa041461.19728603
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18123542
54ABC transporters_Homo sapiens_hsa020101.14771524
55GABAergic synapse_Homo sapiens_hsa047271.12803875
56Sulfur metabolism_Homo sapiens_hsa009201.08448792
57Glycerolipid metabolism_Homo sapiens_hsa005611.06737727
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05412868
59Cholinergic synapse_Homo sapiens_hsa047251.02287153
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01806499
61Calcium signaling pathway_Homo sapiens_hsa040201.01472678
62Allograft rejection_Homo sapiens_hsa053301.01427447
63Insulin secretion_Homo sapiens_hsa049110.99175813
64beta-Alanine metabolism_Homo sapiens_hsa004100.98621299
65RNA degradation_Homo sapiens_hsa030180.98274142
66Fat digestion and absorption_Homo sapiens_hsa049750.97395581
67Rheumatoid arthritis_Homo sapiens_hsa053230.96843532
68Primary immunodeficiency_Homo sapiens_hsa053400.95544129
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94104051
70Wnt signaling pathway_Homo sapiens_hsa043100.93340369
71Sphingolipid metabolism_Homo sapiens_hsa006000.93330029
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92642959
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.91568809
74Autoimmune thyroid disease_Homo sapiens_hsa053200.90690988
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88531941
76Hematopoietic cell lineage_Homo sapiens_hsa046400.86200609
77Basal cell carcinoma_Homo sapiens_hsa052170.85679351
78Long-term potentiation_Homo sapiens_hsa047200.85454151
79Sulfur relay system_Homo sapiens_hsa041220.83695595
80Type I diabetes mellitus_Homo sapiens_hsa049400.83419659
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82877320
82One carbon pool by folate_Homo sapiens_hsa006700.81325304
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80365278
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.80321364
85Fatty acid degradation_Homo sapiens_hsa000710.79007549
86Vitamin digestion and absorption_Homo sapiens_hsa049770.79002915
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78483582
88Basal transcription factors_Homo sapiens_hsa030220.76638449
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75993253
90Axon guidance_Homo sapiens_hsa043600.75159753
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.74467016
92Measles_Homo sapiens_hsa051620.72733844
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72678038
94African trypanosomiasis_Homo sapiens_hsa051430.72475461
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70805638
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70697861
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69256365
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66172789
99Other glycan degradation_Homo sapiens_hsa005110.64625645
100Malaria_Homo sapiens_hsa051440.64325593
101Dorso-ventral axis formation_Homo sapiens_hsa043200.63750390
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62604709
103Vibrio cholerae infection_Homo sapiens_hsa051100.61979666
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61403383
105cAMP signaling pathway_Homo sapiens_hsa040240.61337191
106Asthma_Homo sapiens_hsa053100.60443358
107Histidine metabolism_Homo sapiens_hsa003400.59530551
108Fatty acid biosynthesis_Homo sapiens_hsa000610.59373904
109Metabolic pathways_Homo sapiens_hsa011000.58786197
110Pyrimidine metabolism_Homo sapiens_hsa002400.58398860
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57676043
112Regulation of autophagy_Homo sapiens_hsa041400.53230772
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53117006
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.52801216
115Melanoma_Homo sapiens_hsa052180.52743233
116Dopaminergic synapse_Homo sapiens_hsa047280.51741147
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.51681059
118Renin secretion_Homo sapiens_hsa049240.50774922
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50508824
120Amphetamine addiction_Homo sapiens_hsa050310.49140545
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48965079
122Arginine and proline metabolism_Homo sapiens_hsa003300.48938644
123Fatty acid metabolism_Homo sapiens_hsa012120.48765122
124Thyroid cancer_Homo sapiens_hsa052160.48254194
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.47845953
126Pertussis_Homo sapiens_hsa051330.47379299
127Hedgehog signaling pathway_Homo sapiens_hsa043400.46776822
128* Purine metabolism_Homo sapiens_hsa002300.46483587
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.46075635
130Tyrosine metabolism_Homo sapiens_hsa003500.45535168
131Circadian rhythm_Homo sapiens_hsa047100.44735990
132Mineral absorption_Homo sapiens_hsa049780.44706742
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43877614
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43516904
135Starch and sucrose metabolism_Homo sapiens_hsa005000.43491011
136GnRH signaling pathway_Homo sapiens_hsa049120.42889703
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42007766
138Ovarian steroidogenesis_Homo sapiens_hsa049130.41741165
139PPAR signaling pathway_Homo sapiens_hsa033200.38152653
140Gastric acid secretion_Homo sapiens_hsa049710.36927999
141Leishmaniasis_Homo sapiens_hsa051400.36146141
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.33869532
143Ras signaling pathway_Homo sapiens_hsa040140.33223153
144Ether lipid metabolism_Homo sapiens_hsa005650.33052773
145Phagosome_Homo sapiens_hsa041450.32535434
146Pancreatic secretion_Homo sapiens_hsa049720.28523701
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28510877

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