PDE12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.66362698
2kynurenine metabolic process (GO:0070189)5.06387387
3indole-containing compound catabolic process (GO:0042436)4.81588498
4indolalkylamine catabolic process (GO:0046218)4.81588498
5tryptophan catabolic process (GO:0006569)4.81588498
6indolalkylamine metabolic process (GO:0006586)4.49592581
7fucose catabolic process (GO:0019317)4.45402478
8L-fucose metabolic process (GO:0042354)4.45402478
9L-fucose catabolic process (GO:0042355)4.45402478
10maturation of SSU-rRNA (GO:0030490)4.24972444
11tryptophan metabolic process (GO:0006568)4.17895004
12DNA deamination (GO:0045006)4.10000333
13signal peptide processing (GO:0006465)4.03826520
14regulation of hippo signaling (GO:0035330)3.97891162
15ribosomal small subunit assembly (GO:0000028)3.96393075
16ribosomal large subunit biogenesis (GO:0042273)3.95578967
17DNA replication initiation (GO:0006270)3.89726521
18detection of light stimulus involved in sensory perception (GO:0050962)3.86451370
19detection of light stimulus involved in visual perception (GO:0050908)3.86451370
20detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.83445230
21viral transcription (GO:0019083)3.77834211
22neural tube formation (GO:0001841)3.73201672
23translational termination (GO:0006415)3.70781266
24protein K11-linked deubiquitination (GO:0035871)3.65782022
25positive regulation of developmental pigmentation (GO:0048087)3.56923219
26telomere maintenance via semi-conservative replication (GO:0032201)3.54813459
27ribonucleoprotein complex biogenesis (GO:0022613)3.52104549
28DNA strand elongation involved in DNA replication (GO:0006271)3.50495017
29ribosomal small subunit biogenesis (GO:0042274)3.48851234
30negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.48012789
31negative regulation of translation, ncRNA-mediated (GO:0040033)3.48012789
32regulation of translation, ncRNA-mediated (GO:0045974)3.48012789
33snRNA transcription (GO:0009301)3.46130273
34CENP-A containing nucleosome assembly (GO:0034080)3.45783099
35DNA strand elongation (GO:0022616)3.43850792
36indole-containing compound metabolic process (GO:0042430)3.41511968
37ribosome biogenesis (GO:0042254)3.41445871
38DNA unwinding involved in DNA replication (GO:0006268)3.34640069
39chromatin remodeling at centromere (GO:0031055)3.34595165
40negative regulation of mast cell activation (GO:0033004)3.33333911
41viral mRNA export from host cell nucleus (GO:0046784)3.30546039
42cellular ketone body metabolic process (GO:0046950)3.27608987
43translational initiation (GO:0006413)3.25794380
44protein K48-linked deubiquitination (GO:0071108)3.24227709
45translational elongation (GO:0006414)3.19639146
46DNA replication checkpoint (GO:0000076)3.19582383
47water-soluble vitamin biosynthetic process (GO:0042364)3.19162210
48SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.17002691
49UDP-N-acetylglucosamine metabolic process (GO:0006047)3.16832651
50folic acid-containing compound biosynthetic process (GO:0009396)3.16731510
51serotonin metabolic process (GO:0042428)3.16207838
52double-strand break repair via homologous recombination (GO:0000724)3.15978954
53recombinational repair (GO:0000725)3.14589902
54telomere maintenance via recombination (GO:0000722)3.11443888
55reflex (GO:0060004)3.10338063
56monoubiquitinated protein deubiquitination (GO:0035520)3.10249498
57cotranslational protein targeting to membrane (GO:0006613)3.10168648
58rRNA processing (GO:0006364)3.10032118
59regulation of pigment cell differentiation (GO:0050932)3.10017745
60DNA replication-independent nucleosome organization (GO:0034724)3.09268912
61DNA replication-independent nucleosome assembly (GO:0006336)3.09268912
62rRNA catabolic process (GO:0016075)3.09183936
63protein targeting to ER (GO:0045047)3.08626842
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08556079
65cellular response to ATP (GO:0071318)3.06204915
66methionine biosynthetic process (GO:0009086)3.05428912
67sulfation (GO:0051923)3.04376339
68replicative senescence (GO:0090399)3.04229445
69nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01896847
70rRNA metabolic process (GO:0016072)3.01148943
71L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.01042850
72histone-serine phosphorylation (GO:0035404)3.00130941
73regulation of gene silencing by RNA (GO:0060966)2.99562003
74regulation of posttranscriptional gene silencing (GO:0060147)2.99562003
75regulation of gene silencing by miRNA (GO:0060964)2.99562003
76ketone body metabolic process (GO:1902224)2.99280915
77cytoplasmic mRNA processing body assembly (GO:0033962)2.97877392
78primary amino compound metabolic process (GO:1901160)2.97115618
79positive regulation of gamma-delta T cell activation (GO:0046645)2.96279692
80protein K63-linked deubiquitination (GO:0070536)2.94578950
81regulation of establishment of cell polarity (GO:2000114)2.94433991
82cAMP catabolic process (GO:0006198)2.94114561
83establishment of protein localization to endoplasmic reticulum (GO:0072599)2.92974751
84mitotic recombination (GO:0006312)2.92853034
85oxidative demethylation (GO:0070989)2.92296288
86pseudouridine synthesis (GO:0001522)2.91801293
87nuclear pore complex assembly (GO:0051292)2.90914698
88interkinetic nuclear migration (GO:0022027)2.90361236
89viral life cycle (GO:0019058)2.90071318
90proteasome assembly (GO:0043248)2.85605886
91telomere maintenance via telomere lengthening (GO:0010833)2.84354555
92protein localization to endoplasmic reticulum (GO:0070972)2.84265074
93establishment of protein localization to Golgi (GO:0072600)2.83042223
94cellular protein complex disassembly (GO:0043624)2.82756838
95amine catabolic process (GO:0009310)2.81742471
96cellular biogenic amine catabolic process (GO:0042402)2.81742471
97mitotic nuclear envelope disassembly (GO:0007077)2.80783939
98neuronal action potential (GO:0019228)2.80624098
99regulation of action potential (GO:0098900)2.80156478
100negative regulation of DNA-dependent DNA replication (GO:2000104)2.80111742
101somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.78574218
102isotype switching (GO:0045190)2.78574218
103somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.78574218
104formation of translation preinitiation complex (GO:0001731)2.78388986
105nuclear pore organization (GO:0006999)2.77959578
106ribosome assembly (GO:0042255)2.77438912
107mitotic metaphase plate congression (GO:0007080)2.76797585
108gamma-aminobutyric acid transport (GO:0015812)2.76378345
109prenylation (GO:0097354)2.75979409
110protein prenylation (GO:0018342)2.75979409
111kinetochore organization (GO:0051383)2.74812137
112meiotic chromosome segregation (GO:0045132)2.73908826
113response to pheromone (GO:0019236)2.73434864
114cornea development in camera-type eye (GO:0061303)2.72310027
115cyclic nucleotide catabolic process (GO:0009214)2.71408356
116transcription elongation from RNA polymerase III promoter (GO:0006385)2.71022766
117termination of RNA polymerase III transcription (GO:0006386)2.71022766
118retinal cone cell development (GO:0046549)2.70382196
119proline transport (GO:0015824)2.69716326
120termination of RNA polymerase I transcription (GO:0006363)2.69388343
121negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66647069
122behavioral response to ethanol (GO:0048149)2.66440032
123magnesium ion transport (GO:0015693)2.65743016
124nuclear-transcribed mRNA catabolic process (GO:0000956)2.65612207
125acrosome assembly (GO:0001675)2.65047788
126protein localization to chromosome, centromeric region (GO:0071459)2.65032105
127nucleobase biosynthetic process (GO:0046112)2.64236975
128negative regulation by host of viral transcription (GO:0043922)2.64120624
129regulation of nuclear cell cycle DNA replication (GO:0033262)2.62909931
130benzene-containing compound metabolic process (GO:0042537)2.61738249
131spliceosomal snRNP assembly (GO:0000387)2.61710571
132DNA replication-dependent nucleosome assembly (GO:0006335)2.61486959
133DNA replication-dependent nucleosome organization (GO:0034723)2.61486959
134L-methionine salvage (GO:0071267)2.60936029
135L-methionine biosynthetic process (GO:0071265)2.60936029
136amino acid salvage (GO:0043102)2.60936029
137somite rostral/caudal axis specification (GO:0032525)2.60664292
138protein K6-linked ubiquitination (GO:0085020)2.60220051
139microtubule anchoring (GO:0034453)2.60056450
140reciprocal meiotic recombination (GO:0007131)2.59861136
141reciprocal DNA recombination (GO:0035825)2.59861136
142translation (GO:0006412)2.59669131
143protein polyglutamylation (GO:0018095)2.59284011
144protein localization to kinetochore (GO:0034501)2.59264156
145histone exchange (GO:0043486)2.59226581
146nuclear envelope disassembly (GO:0051081)2.59189476
147membrane disassembly (GO:0030397)2.59189476
148cellular response to ethanol (GO:0071361)2.58168218
149deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.57912988
150cell morphogenesis involved in neuron differentiation (GO:0048667)2.56937190
151replication fork processing (GO:0031297)2.56896469
152kinetochore assembly (GO:0051382)2.56383216
153endosome to melanosome transport (GO:0035646)2.55745716
154endosome to pigment granule transport (GO:0043485)2.55745716
155mRNA catabolic process (GO:0006402)2.55630821
156auditory receptor cell stereocilium organization (GO:0060088)2.54336969
157negative regulation of systemic arterial blood pressure (GO:0003085)2.54062049
158ubiquinone biosynthetic process (GO:0006744)2.54032641
159cellular component biogenesis (GO:0044085)2.53314077
160positive regulation of steroid hormone secretion (GO:2000833)2.53226658
161preassembly of GPI anchor in ER membrane (GO:0016254)2.52303735
162alanine transport (GO:0032328)2.52270786
163nucleotide-excision repair, DNA gap filling (GO:0006297)2.52176860
164tRNA methylation (GO:0030488)2.51772528
165peptidyl-histidine modification (GO:0018202)2.51715703
166metaphase plate congression (GO:0051310)2.51422254
167cilium morphogenesis (GO:0060271)2.50624491
168negative regulation of telomere maintenance (GO:0032205)2.50069425
169regulation of RIG-I signaling pathway (GO:0039535)2.49741642
170protein complex disassembly (GO:0043241)2.49390552
171RNA catabolic process (GO:0006401)2.49282746
172regulation of glucokinase activity (GO:0033131)2.48671713
173regulation of hexokinase activity (GO:1903299)2.48671713
174transcription elongation from RNA polymerase I promoter (GO:0006362)2.47847346
175G1/S transition of mitotic cell cycle (GO:0000082)2.46455506
176cell cycle G1/S phase transition (GO:0044843)2.46455506
177histone mRNA metabolic process (GO:0008334)2.44608169
178regulation of histone H3-K9 methylation (GO:0051570)2.40487493
179transcription from RNA polymerase I promoter (GO:0006360)2.39128712
180NIK/NF-kappaB signaling (GO:0038061)2.38833121
181purine nucleobase biosynthetic process (GO:0009113)2.35997506
182mitotic G2 DNA damage checkpoint (GO:0007095)2.35832262
183telomere organization (GO:0032200)2.35254085
184telomere maintenance (GO:0000723)2.35214961
185macromolecular complex disassembly (GO:0032984)2.34374911
186rRNA modification (GO:0000154)2.34226165
187ncRNA processing (GO:0034470)2.33959769
188transcription-coupled nucleotide-excision repair (GO:0006283)2.33662929
189DNA-templated transcription, termination (GO:0006353)2.31575639
190mismatch repair (GO:0006298)2.31427362
191establishment of chromosome localization (GO:0051303)2.31085756
192mitotic G2/M transition checkpoint (GO:0044818)2.30625512
193maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.30590512
194regulation of double-strand break repair via homologous recombination (GO:0010569)2.30227542
195nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.30065477
196somatic recombination of immunoglobulin gene segments (GO:0016447)2.29961128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.41227114
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.95491269
3ZNF274_21170338_ChIP-Seq_K562_Hela3.81551068
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.55525495
5VDR_22108803_ChIP-Seq_LS180_Human3.18973635
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.14363209
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.13649296
8GBX2_23144817_ChIP-Seq_PC3_Human3.09005747
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.99431536
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.94836520
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92886611
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.78429322
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76544404
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.76009622
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.72951380
16EWS_26573619_Chip-Seq_HEK293_Human2.67923670
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.62230742
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.55947221
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55941490
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.53882010
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.47934551
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.47555210
23* ETS1_20019798_ChIP-Seq_JURKAT_Human2.45357345
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42322567
25TAF15_26573619_Chip-Seq_HEK293_Human2.42271043
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42265647
27FUS_26573619_Chip-Seq_HEK293_Human2.41734741
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.40014542
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39430889
30IGF1R_20145208_ChIP-Seq_DFB_Human2.39074507
31EGR1_19374776_ChIP-ChIP_THP-1_Human2.37122184
32ELK1_19687146_ChIP-ChIP_HELA_Human2.33839969
33* VDR_23849224_ChIP-Seq_CD4+_Human2.32074369
34FLI1_27457419_Chip-Seq_LIVER_Mouse2.27948855
35CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23300701
36* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.22539732
37ER_23166858_ChIP-Seq_MCF-7_Human2.16351782
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13359519
39NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07014530
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06222883
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04467709
42P300_19829295_ChIP-Seq_ESCs_Human2.02940209
43EZH2_22144423_ChIP-Seq_EOC_Human1.98302246
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98113837
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96562642
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.95649622
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93451848
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.93278784
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93074951
50FOXP3_21729870_ChIP-Seq_TREG_Human1.92370480
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92070366
52* XRN2_22483619_ChIP-Seq_HELA_Human1.90299797
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89862832
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.87176324
55AR_21572438_ChIP-Seq_LNCaP_Human1.84070590
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80786199
57DCP1A_22483619_ChIP-Seq_HELA_Human1.80291742
58* STAT3_23295773_ChIP-Seq_U87_Human1.79284216
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79076203
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77822301
61TTF2_22483619_ChIP-Seq_HELA_Human1.77257819
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74303303
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71942560
64MYC_22102868_ChIP-Seq_BL_Human1.68885444
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68350248
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68318161
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67229548
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66596677
69IRF1_19129219_ChIP-ChIP_H3396_Human1.64455066
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60894837
71AR_21909140_ChIP-Seq_LNCAP_Human1.60382831
72STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59502393
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58619693
74SMAD4_21799915_ChIP-Seq_A2780_Human1.57978254
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56988120
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56216595
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54118186
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54060065
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51508151
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50910629
81GABP_19822575_ChIP-Seq_HepG2_Human1.50547904
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.49883755
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48986157
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48012175
85CBP_20019798_ChIP-Seq_JUKART_Human1.48012175
86TCF4_23295773_ChIP-Seq_U87_Human1.46795136
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46635840
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45860431
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45793031
90BCAT_22108803_ChIP-Seq_LS180_Human1.45739691
91SPI1_23547873_ChIP-Seq_NB4_Human1.45282029
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44704631
93* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43064370
94AR_25329375_ChIP-Seq_VCAP_Human1.42887512
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42303815
96CIITA_25753668_ChIP-Seq_RAJI_Human1.41485796
97IRF8_22096565_ChIP-ChIP_GC-B_Human1.39248686
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36172542
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34943532
100TP53_16413492_ChIP-PET_HCT116_Human1.33322886
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32812165
102YY1_21170310_ChIP-Seq_MESCs_Mouse1.32750550
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.32625726
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31992413
105* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31692114
106STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31644874
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31484711
108* FLI1_21867929_ChIP-Seq_TH2_Mouse1.30927954
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30128028
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30128028
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29132923
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29007986
113MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28557616
114MYB_26560356_Chip-Seq_TH2_Human1.28467341
115MYC_18940864_ChIP-ChIP_HL60_Human1.28317670
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28005890
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.27304154
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26128729
119NFE2_27457419_Chip-Seq_LIVER_Mouse1.24685519
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.23394609
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22582634
122TP53_22573176_ChIP-Seq_HFKS_Human1.22527579
123STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22221274
124MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21699925
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21519867
126MYB_26560356_Chip-Seq_TH1_Human1.21219669
127TP63_17297297_ChIP-ChIP_HaCaT_Human1.20983474
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20727779
129TCF4_22108803_ChIP-Seq_LS180_Human1.20630993
130RUNX2_22187159_ChIP-Seq_PCA_Human1.20541933
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18962077
132THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18352316
133VDR_21846776_ChIP-Seq_THP-1_Human1.17757983
134PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16135246
135CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15709866
136SRF_21415370_ChIP-Seq_HL-1_Mouse1.14607069
137E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14310236
138MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13790404
139NANOG_18555785_Chip-Seq_ESCs_Mouse1.13711630
140SMAD4_21741376_ChIP-Seq_EPCs_Human1.13024397
141CBX2_27304074_Chip-Seq_ESCs_Mouse1.12001002
142SCL_19346495_ChIP-Seq_HPC-7_Human1.11710747
143NANOG_19829295_ChIP-Seq_ESCs_Human1.11469813
144SOX2_19829295_ChIP-Seq_ESCs_Human1.11469813
145ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10937246
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09796381
147ELK1_22589737_ChIP-Seq_MCF10A_Human1.09354511
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09318241
149CRX_20693478_ChIP-Seq_RETINA_Mouse1.08598928
150P53_22387025_ChIP-Seq_ESCs_Mouse1.05740873
151ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05506717
152AHR_22903824_ChIP-Seq_MCF-7_Human1.05402866
153TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05041355
154ARNT_22903824_ChIP-Seq_MCF-7_Human1.04035859
155TFEB_21752829_ChIP-Seq_HELA_Human1.03696260
156IRF8_21731497_ChIP-ChIP_J774_Mouse1.03613691
157* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03081511
158BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03066728
159EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02582807
160KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02291241
161* CDX2_22108803_ChIP-Seq_LS180_Human1.01730299
162SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00285946
163E2F1_18555785_Chip-Seq_ESCs_Mouse1.00215435
164HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99944563
165HOXB7_26014856_ChIP-Seq_BT474_Human0.99198837
166PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99012457
167FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97074328
168FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96559815
169KDM5A_27292631_Chip-Seq_BREAST_Human0.96411845
170STAT3_18555785_Chip-Seq_ESCs_Mouse0.96361498
171SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96205036
172E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96100250
173JUN_21703547_ChIP-Seq_K562_Human0.95308083
174REST_21632747_ChIP-Seq_MESCs_Mouse0.95140660
175* FOXA1_25329375_ChIP-Seq_VCAP_Human0.94998435
176* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94998435
177FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94301487
178GATA3_21878914_ChIP-Seq_MCF-7_Human0.94026685
179MAF_26560356_Chip-Seq_TH1_Human0.93621630
180RUNX1_22412390_ChIP-Seq_EML_Mouse0.93485600
181STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91310140
182* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86427457
183CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86314409
184POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85693444
185UTX_26944678_Chip-Seq_JUKART_Human0.85360252
186* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.85165804
187HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84171133
188KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83579171

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.75737159
2MP0003693_abnormal_embryo_hatching3.81555135
3MP0008057_abnormal_DNA_replication3.77452794
4MP0010094_abnormal_chromosome_stability3.45937825
5MP0003195_calcinosis3.45544680
6MP0003111_abnormal_nucleus_morphology3.04978205
7MP0002396_abnormal_hematopoietic_system2.97445791
8MP0008058_abnormal_DNA_repair2.80690182
9MP0003077_abnormal_cell_cycle2.73247986
10MP0008007_abnormal_cellular_replicative2.70695236
11MP0000427_abnormal_hair_cycle2.56920152
12MP0004957_abnormal_blastocyst_morpholog2.47255862
13MP0003763_abnormal_thymus_physiology2.41544217
14MP0009046_muscle_twitch2.26225250
15MP0004043_abnormal_pH_regulation2.25479082
16MP0003646_muscle_fatigue2.20879686
17MP0000490_abnormal_crypts_of2.17731567
18MP0005551_abnormal_eye_electrophysiolog2.16840527
19MP0003890_abnormal_embryonic-extraembry2.09119268
20MP0008961_abnormal_basal_metabolism2.00682223
21MP0002132_abnormal_respiratory_system1.97475994
22MP0003724_increased_susceptibility_to1.96046958
23MP0005451_abnormal_body_composition1.92320837
24MP0002876_abnormal_thyroid_physiology1.92174495
25MP0006072_abnormal_retinal_apoptosis1.87233073
26MP0005253_abnormal_eye_physiology1.81812992
27MP0004142_abnormal_muscle_tone1.80459698
28MP0001968_abnormal_touch/_nociception1.77746957
29MP0002638_abnormal_pupillary_reflex1.77605963
30MP0001485_abnormal_pinna_reflex1.77470839
31MP0001800_abnormal_humoral_immune1.75868345
32MP0002398_abnormal_bone_marrow1.75129735
33MP0001501_abnormal_sleep_pattern1.75086099
34MP0009785_altered_susceptibility_to1.68218954
35MP0005671_abnormal_response_to1.65257903
36MP0004381_abnormal_hair_follicle1.64937338
37MP0005645_abnormal_hypothalamus_physiol1.62708484
38MP0001853_heart_inflammation1.62582381
39MP0009745_abnormal_behavioral_response1.62414981
40MP0002148_abnormal_hypersensitivity_rea1.61620501
41MP0002452_abnormal_antigen_presenting1.61307328
42MP0002723_abnormal_immune_serum1.60931241
43MP0002420_abnormal_adaptive_immunity1.60920079
44MP0003136_yellow_coat_color1.60570942
45MP0009333_abnormal_splenocyte_physiolog1.60442645
46MP0001835_abnormal_antigen_presentation1.59851271
47MP0005000_abnormal_immune_tolerance1.59828054
48MP0000703_abnormal_thymus_morphology1.58770527
49MP0002722_abnormal_immune_system1.58250008
50MP0010386_abnormal_urinary_bladder1.58042271
51MP0001819_abnormal_immune_cell1.57759469
52MP0002405_respiratory_system_inflammati1.57623821
53MP0008932_abnormal_embryonic_tissue1.55532322
54MP0002938_white_spotting1.55058734
55MP0001545_abnormal_hematopoietic_system1.54462002
56MP0005397_hematopoietic_system_phenotyp1.54462002
57MP0002160_abnormal_reproductive_system1.52789332
58MP0003436_decreased_susceptibility_to1.48732516
59MP0003786_premature_aging1.48430101
60MP0000716_abnormal_immune_system1.47655645
61MP0000689_abnormal_spleen_morphology1.47629421
62MP0004808_abnormal_hematopoietic_stem1.47313906
63MP0005187_abnormal_penis_morphology1.46431729
64MP0005171_absent_coat_pigmentation1.45726082
65MP0009379_abnormal_foot_pigmentation1.45712994
66MP0010352_gastrointestinal_tract_polyps1.44358550
67MP0000465_gastrointestinal_hemorrhage1.43979333
68MP0002006_tumorigenesis1.43107241
69MP0005387_immune_system_phenotype1.40864026
70MP0001790_abnormal_immune_system1.40864026
71MP0008875_abnormal_xenobiotic_pharmacok1.39181033
72MP0002166_altered_tumor_susceptibility1.39179264
73MP0000631_abnormal_neuroendocrine_gland1.37971403
74MP0001986_abnormal_taste_sensitivity1.37537718
75MP0002019_abnormal_tumor_incidence1.37388531
76MP0000350_abnormal_cell_proliferation1.36802078
77MP0010155_abnormal_intestine_physiology1.36597842
78MP0005025_abnormal_response_to1.35213590
79MP0002429_abnormal_blood_cell1.34898713
80MP0000685_abnormal_immune_system1.34165460
81MP0005409_darkened_coat_color1.33469554
82MP0009697_abnormal_copulation1.29646720
83MP0003880_abnormal_central_pattern1.26340492
84MP0000015_abnormal_ear_pigmentation1.24866724
85MP0004742_abnormal_vestibular_system1.23352181
86MP0008872_abnormal_physiological_respon1.22934566
87MP0000647_abnormal_sebaceous_gland1.22855226
88MP0001919_abnormal_reproductive_system1.22577295
89MP0005389_reproductive_system_phenotype1.22419249
90MP0002928_abnormal_bile_duct1.21490657
91MP0008877_abnormal_DNA_methylation1.21430108
92MP0004924_abnormal_behavior1.21264011
93MP0005386_behavior/neurological_phenoty1.21264011
94MP0002234_abnormal_pharynx_morphology1.21138872
95MP0004947_skin_inflammation1.21135084
96MP0002419_abnormal_innate_immunity1.21053354
97MP0002277_abnormal_respiratory_mucosa1.19588621
98MP0002064_seizures1.18796255
99MP0000372_irregular_coat_pigmentation1.18186921
100MP0002272_abnormal_nervous_system1.17908418
101MP0002067_abnormal_sensory_capabilities1.17562569
102MP0003950_abnormal_plasma_membrane1.16547217
103MP0004215_abnormal_myocardial_fiber1.15243523
104MP0005167_abnormal_blood-brain_barrier1.14494326
105MP0001873_stomach_inflammation1.13453102
106MP0002736_abnormal_nociception_after1.13244999
107MP0005266_abnormal_metabolism1.12950658
108MP0003718_maternal_effect1.12875795
109MP0000371_diluted_coat_color1.12680941
110MP0002009_preneoplasia1.12617703
111MP0005174_abnormal_tail_pigmentation1.11412557
112MP0002933_joint_inflammation1.10490358
113MP0002837_dystrophic_cardiac_calcinosis1.10241160
114MP0003937_abnormal_limbs/digits/tail_de1.08823026
115MP0004130_abnormal_muscle_cell1.08556450
116MP0005310_abnormal_salivary_gland1.07140880
117MP0000538_abnormal_urinary_bladder1.06817360
118MP0000383_abnormal_hair_follicle1.06505332
119MP0002735_abnormal_chemical_nociception1.06256981
120MP0002572_abnormal_emotion/affect_behav1.05143583
121MP0004133_heterotaxia1.02905763
122MP0002095_abnormal_skin_pigmentation1.02686155
123MP0010307_abnormal_tumor_latency1.02009956
124MP0005075_abnormal_melanosome_morpholog1.01746715
125MP0010678_abnormal_skin_adnexa1.01703188
126MP0005195_abnormal_posterior_eye1.01049004
127MP0000313_abnormal_cell_death1.00929191
128MP0001486_abnormal_startle_reflex0.97609875
129MP0006276_abnormal_autonomic_nervous0.97272169
130MP0000858_altered_metastatic_potential0.96541178
131MP0001324_abnormal_eye_pigmentation0.96303641
132MP0002557_abnormal_social/conspecific_i0.96253129
133MP0005085_abnormal_gallbladder_physiolo0.94819764
134MP0001529_abnormal_vocalization0.94663632
135MP0001730_embryonic_growth_arrest0.94024026
136MP0004147_increased_porphyrin_level0.93788199
137MP0003448_altered_tumor_morphology0.93442621
138MP0005464_abnormal_platelet_physiology0.93028402
139MP0003300_gastrointestinal_ulcer0.92208916
140MP0001216_abnormal_epidermal_layer0.91881688
141MP0001845_abnormal_inflammatory_respons0.91430792
142MP0006292_abnormal_olfactory_placode0.90792226
143MP0005670_abnormal_white_adipose0.89964050
144MP0003252_abnormal_bile_duct0.88363779
145MP0002653_abnormal_ependyma_morphology0.87736717
146MP0005647_abnormal_sex_gland0.87731827
147MP0005379_endocrine/exocrine_gland_phen0.86708501
148MP0005646_abnormal_pituitary_gland0.85056254
149MP0004145_abnormal_muscle_electrophysio0.84884395
150MP0003828_pulmonary_edema0.84672443
151MP0004885_abnormal_endolymph0.84403186
152MP0003959_abnormal_lean_body0.83702378
153MP0005391_vision/eye_phenotype0.83300501
154MP0002138_abnormal_hepatobiliary_system0.82754206
155MP0006054_spinal_hemorrhage0.81247127
156MP0002733_abnormal_thermal_nociception0.80741614
157MP0003186_abnormal_redox_activity0.80442642
158MP0000778_abnormal_nervous_system0.78833480
159MP0002877_abnormal_melanocyte_morpholog0.78405638
160MP0002102_abnormal_ear_morphology0.78154236
161MP0005410_abnormal_fertilization0.77574885
162MP0005380_embryogenesis_phenotype0.75715798
163MP0001672_abnormal_embryogenesis/_devel0.75715798
164MP0001697_abnormal_embryo_size0.74802034
165MP0002210_abnormal_sex_determination0.74210267
166MP0003453_abnormal_keratinocyte_physiol0.74065467
167MP0008995_early_reproductive_senescence0.73101232
168MP0005501_abnormal_skin_physiology0.73064425
169MP0001970_abnormal_pain_threshold0.72419327
170MP0002090_abnormal_vision0.71893257
171MP0005448_abnormal_energy_balance0.71107165
172MP0002080_prenatal_lethality0.70976628
173MP0001191_abnormal_skin_condition0.70957785
174MP0001851_eye_inflammation0.69807059
175MP0000477_abnormal_intestine_morphology0.69346527
176MP0003567_abnormal_fetal_cardiomyocyte0.68920024
177MP0001915_intracranial_hemorrhage0.68364047
178MP0003866_abnormal_defecation0.65566925
179MP0001533_abnormal_skeleton_physiology0.65248360
180MP0002163_abnormal_gland_morphology0.64551489

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.07041372
2Reticulocytopenia (HP:0001896)4.48485001
3Abnormality of cells of the erythroid lineage (HP:0012130)4.22021233
4Pancreatic cysts (HP:0001737)4.13529898
5Hyperventilation (HP:0002883)4.11184471
6Chromsome breakage (HP:0040012)3.98969785
7Birth length less than 3rd percentile (HP:0003561)3.95890745
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.95611341
9Abnormality of alanine metabolism (HP:0010916)3.95611341
10Hyperalaninemia (HP:0003348)3.95611341
11Abnormal number of erythroid precursors (HP:0012131)3.93777105
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.89341567
13Abnormality of midbrain morphology (HP:0002418)3.85314829
14Molar tooth sign on MRI (HP:0002419)3.85314829
15Genetic anticipation (HP:0003743)3.38123367
16Pancreatic fibrosis (HP:0100732)3.36540864
17Pallor (HP:0000980)3.26845125
18Protruding tongue (HP:0010808)3.25573242
19True hermaphroditism (HP:0010459)3.23521267
20Nephronophthisis (HP:0000090)3.23496732
21Abnormality of the renal cortex (HP:0011035)3.21403455
22Progressive inability to walk (HP:0002505)3.16292992
23Fair hair (HP:0002286)3.09995350
24Large for gestational age (HP:0001520)2.99095815
25Clumsiness (HP:0002312)2.99063123
26Type II lissencephaly (HP:0007260)2.98212454
27Abnormality of the preputium (HP:0100587)2.97569442
28Inability to walk (HP:0002540)2.97505336
29Abnormality of the renal medulla (HP:0100957)2.95995391
30Concave nail (HP:0001598)2.87518003
31Gaze-evoked nystagmus (HP:0000640)2.86840859
32IgM deficiency (HP:0002850)2.81731740
33Panhypogammaglobulinemia (HP:0003139)2.81480638
34Macrocytic anemia (HP:0001972)2.80408377
35Abnormality of chromosome stability (HP:0003220)2.80089317
36Attenuation of retinal blood vessels (HP:0007843)2.77930882
37Chronic hepatic failure (HP:0100626)2.74498460
38Abnormality of the columella (HP:0009929)2.73487228
39Absent thumb (HP:0009777)2.62986639
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.61984846
41Oral leukoplakia (HP:0002745)2.59264281
42Lissencephaly (HP:0001339)2.58112660
43Breast hypoplasia (HP:0003187)2.54167405
44Abnormality of the pons (HP:0007361)2.53635612
45B lymphocytopenia (HP:0010976)2.52765090
46Abnormality of B cell number (HP:0010975)2.52765090
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.52705922
48Generalized hypopigmentation of hair (HP:0011358)2.50638775
49Aplastic anemia (HP:0001915)2.50239638
50Selective tooth agenesis (HP:0001592)2.49638650
51Recurrent viral infections (HP:0004429)2.47137550
52Broad-based gait (HP:0002136)2.45673879
53Tubular atrophy (HP:0000092)2.45560911
54Progressive cerebellar ataxia (HP:0002073)2.43526834
55Lymphoma (HP:0002665)2.42790397
56Furrowed tongue (HP:0000221)2.42775307
57T lymphocytopenia (HP:0005403)2.42273728
58Meckel diverticulum (HP:0002245)2.42199136
59Renal cortical cysts (HP:0000803)2.42097952
60Recurrent fungal infections (HP:0002841)2.39246915
61Hypoplasia of the pons (HP:0012110)2.38382453
62Abnormality of T cell number (HP:0011839)2.38295645
63Cystic liver disease (HP:0006706)2.38157694
64Aplasia/Hypoplasia of the tibia (HP:0005772)2.34705297
65Myelodysplasia (HP:0002863)2.31511659
66Ectopic kidney (HP:0000086)2.31260555
67Rough bone trabeculation (HP:0100670)2.30259177
68Patellar aplasia (HP:0006443)2.29432232
69Reduced antithrombin III activity (HP:0001976)2.29424986
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.29245245
71Abnormality of the ileum (HP:0001549)2.29088464
72Duplicated collecting system (HP:0000081)2.29007434
73Sparse eyelashes (HP:0000653)2.28383521
74Sclerocornea (HP:0000647)2.26376640
75Bone marrow hypocellularity (HP:0005528)2.26069894
76Pulmonary fibrosis (HP:0002206)2.25427141
77Medial flaring of the eyebrow (HP:0010747)2.22610249
78Decreased circulating renin level (HP:0003351)2.21866785
7911 pairs of ribs (HP:0000878)2.20969633
80Abnormality of the renal collecting system (HP:0004742)2.20363535
81Clubbing of toes (HP:0100760)2.19651425
82Widely spaced teeth (HP:0000687)2.18737737
83Eosinophilia (HP:0001880)2.18682712
84Sparse scalp hair (HP:0002209)2.17999547
85Thrombocytosis (HP:0001894)2.16001824
86Aplasia/Hypoplasia of the patella (HP:0006498)2.15686992
87Absent speech (HP:0001344)2.15154159
88Abnormal rod and cone electroretinograms (HP:0008323)2.13378497
89Abnormality of T cells (HP:0002843)2.13109148
90Central scotoma (HP:0000603)2.13008258
91Prolonged bleeding time (HP:0003010)2.11787174
92Type I transferrin isoform profile (HP:0003642)2.11636636
93Cerebellar dysplasia (HP:0007033)2.10639381
94Short middle phalanx of the 5th finger (HP:0004220)2.10413673
95Abnormality of the prostate (HP:0008775)2.09563756
96Granulocytopenia (HP:0001913)2.08383619
97Myositis (HP:0100614)2.06681605
98Muscle fiber atrophy (HP:0100295)2.06613437
99Febrile seizures (HP:0002373)2.06598614
100Pendular nystagmus (HP:0012043)2.06060941
101Severe combined immunodeficiency (HP:0004430)2.05403946
102Abolished electroretinogram (ERG) (HP:0000550)2.05399135
103Alopecia of scalp (HP:0002293)2.05262638
104Eczematoid dermatitis (HP:0000976)2.04541590
105Small hand (HP:0200055)2.04074426
106Stomach cancer (HP:0012126)2.04042207
107Mediastinal lymphadenopathy (HP:0100721)2.03847606
108Abnormality of macular pigmentation (HP:0008002)2.03728180
109Chorioretinal atrophy (HP:0000533)2.02784607
110Abnormal drinking behavior (HP:0030082)2.01783936
111Polydipsia (HP:0001959)2.01783936
112Petechiae (HP:0000967)2.00725561
113Leukopenia (HP:0001882)2.00379446
114Squamous cell carcinoma (HP:0002860)2.00304398
115Stenosis of the external auditory canal (HP:0000402)2.00302451
116Congenital hepatic fibrosis (HP:0002612)1.99419311
117Hypoplasia of the fovea (HP:0007750)1.99133326
118Aplasia/Hypoplasia of the fovea (HP:0008060)1.99133326
119IgG deficiency (HP:0004315)1.99069194
120Keratoconus (HP:0000563)1.98656869
121Increased corneal curvature (HP:0100692)1.98656869
122Elevated erythrocyte sedimentation rate (HP:0003565)1.97285525
123Hypoplastic labia majora (HP:0000059)1.96840611
124Upper limb muscle weakness (HP:0003484)1.96486532
125Partial agenesis of the corpus callosum (HP:0001338)1.96054367
126Triphalangeal thumb (HP:0001199)1.96010978
127Premature graying of hair (HP:0002216)1.95517441
128Recurrent cutaneous fungal infections (HP:0011370)1.94747314
129Chronic mucocutaneous candidiasis (HP:0002728)1.94747314
130Aplasia/Hypoplasia of the tongue (HP:0010295)1.93676993
131Optic neuritis (HP:0100653)1.92964678
132Retrobulbar optic neuritis (HP:0100654)1.92964678
133Abnormality of DNA repair (HP:0003254)1.92350200
134Abnormality of the fovea (HP:0000493)1.91786754
135Severe muscular hypotonia (HP:0006829)1.91621241
136Autoimmune hemolytic anemia (HP:0001890)1.90772891
137Optic nerve coloboma (HP:0000588)1.90717577
138Abnormality of the heme biosynthetic pathway (HP:0010472)1.90499046
139Colon cancer (HP:0003003)1.90336626
140Stomatitis (HP:0010280)1.90064420
141Small intestinal stenosis (HP:0012848)1.89432444
142Duodenal stenosis (HP:0100867)1.89432444
143Prostate neoplasm (HP:0100787)1.88972681
144Abnormality of eosinophils (HP:0001879)1.88939945
145Albinism (HP:0001022)1.88712416
146Acute myeloid leukemia (HP:0004808)1.87988537
147Abnormality of the labia majora (HP:0012881)1.87296491
148Medulloblastoma (HP:0002885)1.86963704
149Carpal bone hypoplasia (HP:0001498)1.85431850
150Recurrent abscess formation (HP:0002722)1.85386480
151Blepharitis (HP:0000498)1.84629269
152Type 2 muscle fiber atrophy (HP:0003554)1.84504426
153Highly arched eyebrow (HP:0002553)1.84018056
154Ectropion (HP:0000656)1.79701621
155Abnormal trabecular bone morphology (HP:0100671)1.79613997
156Sloping forehead (HP:0000340)1.79408891
157Amaurosis fugax (HP:0100576)1.79167740
158Entropion (HP:0000621)1.78855066
159Abnormality of T cell physiology (HP:0011840)1.78561835
160Abnormal delayed hypersensitivity skin test (HP:0002963)1.78271259
161Chronic obstructive pulmonary disease (HP:0006510)1.78066114
162Obstructive lung disease (HP:0006536)1.78066114
163Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77351801
164Absent radius (HP:0003974)1.77304721
165Combined immunodeficiency (HP:0005387)1.77183846
166Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74712377
167Severe visual impairment (HP:0001141)1.74688529
168Bony spicule pigmentary retinopathy (HP:0007737)1.74587980
169Global brain atrophy (HP:0002283)1.74316337
170Congenital, generalized hypertrichosis (HP:0004540)1.74066363
171Drooling (HP:0002307)1.73150568
172Intellectual disability, progressive (HP:0006887)1.73064456
173Erythema (HP:0010783)1.72919152
174Decreased central vision (HP:0007663)1.71899231
175Scotoma (HP:0000575)1.71282833
176Nephrogenic diabetes insipidus (HP:0009806)1.67953055
177Astigmatism (HP:0000483)1.66568990
178Anencephaly (HP:0002323)1.66256805
179Gait imbalance (HP:0002141)1.65876081
180Dandy-Walker malformation (HP:0001305)1.65289442
181Acute lymphatic leukemia (HP:0006721)1.64657061
182Congenital primary aphakia (HP:0007707)1.63786546
183Polyuria (HP:0000103)1.62706078
184Congenital sensorineural hearing impairment (HP:0008527)1.61405426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.22571842
2MKNK26.21472439
3MKNK14.53330997
4TNIK3.77982582
5NME22.83266915
6STK162.54943091
7INSRR2.48230908
8WEE12.46599419
9CAMKK22.39091063
10AKT32.35491357
11GRK12.17502238
12PNCK2.15457536
13SRPK12.11175899
14MAP4K11.98640500
15CAMK1D1.93207452
16WNK31.89100292
17BUB11.82032769
18WNK41.81035866
19CDC71.80151249
20BLK1.79286053
21DYRK31.77528727
22TLK11.74967446
23MAP3K141.73306668
24RPS6KA41.73214995
25PIM21.72274552
26ACVR1B1.64019732
27STK101.61846226
28VRK11.59643643
29ZAK1.58889844
30TXK1.57109317
31MAP3K41.56554814
32CAMK1G1.50899434
33CASK1.46314013
34IRAK31.45441046
35NEK21.43504994
36EIF2AK21.41585078
37MAPK131.38643865
38NLK1.38333876
39IRAK41.37961389
40STK391.37585539
41TSSK61.37373280
42EPHA21.37326134
43STK38L1.35880512
44RPS6KB21.34923748
45TEC1.32358356
46ATR1.26439009
47JAK31.25792450
48EIF2AK11.25323245
49TAOK31.24285248
50TTK1.21629158
51EIF2AK31.16859809
52CDK71.15553735
53OXSR11.15352154
54ADRBK11.13099398
55IKBKB1.11423317
56CHEK21.07950575
57ZAP701.05752933
58PINK11.04516687
59CDK41.03035197
60AURKB1.02640126
61PAK31.02291298
62ITK1.00896746
63PIM10.96163783
64MAP2K70.94700166
65PLK10.93753245
66ERBB30.93557585
67MAP3K30.91397129
68BRD40.90987675
69PBK0.90822610
70TYK20.90389900
71STK40.88425013
72KDR0.87885143
73TGFBR10.87614714
74AURKA0.85738702
75RPS6KA50.84829677
76MST40.84438869
77PLK40.83297796
78CLK10.80933865
79MAP3K80.79413854
80IKBKE0.79328454
81PRKAA20.77185718
82BRSK20.77131301
83CSNK1A1L0.76529484
84BTK0.76325696
85CHUK0.73745040
86MAPK150.73329378
87CHEK10.72734033
88PTK2B0.72112431
89EEF2K0.72061492
90TIE10.71453497
91ATM0.69303899
92TBK10.68458139
93CSNK1G20.67415998
94LCK0.67245467
95CDK90.65574943
96KIT0.65460982
97PRKCG0.62047502
98TAF10.61277602
99PRKAA10.61256236
100IRAK10.61139141
101CDK120.58985355
102MAPKAPK50.58651748
103LYN0.56757295
104BMPR1B0.56325229
105TRPM70.56051745
106PRKCE0.53950699
107PASK0.53323973
108CSNK1G10.53286126
109SCYL20.52372862
110MAP3K110.51662913
111FLT30.51101512
112MAPKAPK30.51011000
113CDK80.49942384
114BCR0.49858171
115MELK0.49440845
116TGFBR20.49091481
117SYK0.48726951
118DAPK20.48602316
119RIPK10.47838197
120PLK30.47559341
121CSNK2A10.47472266
122TAOK20.47207328
123CSNK1G30.46902974
124CSNK2A20.45487195
125SGK20.44798237
126PIK3CG0.43755426
127TESK20.43752497
128MAPKAPK20.43196233
129NUAK10.41907749
130NTRK30.41619612
131LATS10.41609524
132NEK90.41561485
133MAP4K20.40259065
134CDK20.39499721
135GRK60.39011347
136MUSK0.38523025
137CAMK40.38200381
138CDK60.37406178
139DYRK20.37265019
140PIK3CA0.36750142
141MAP2K30.35504131
142ADRBK20.34444270
143CSNK1D0.34025342
144CAMK2A0.33874923
145TRIM280.33655133
146CAMKK10.33361286
147CAMK10.32867428
148MAPK110.32168045
149NEK60.31494523
150CDK30.31056759
151MAP3K100.30765305
152PKN10.30628880
153STK110.30430024
154FER0.29788600
155STK30.28646614
156CSNK1A10.26165306
157RPS6KA60.25158203
158PRKACA0.23644726

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.67985995
2Ribosome_Homo sapiens_hsa030103.42482856
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.94195732
4Mismatch repair_Homo sapiens_hsa034302.90191553
5RNA polymerase_Homo sapiens_hsa030202.84711670
6Homologous recombination_Homo sapiens_hsa034402.55418788
7Spliceosome_Homo sapiens_hsa030402.53766231
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.45064289
9Linoleic acid metabolism_Homo sapiens_hsa005912.34397184
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.34225982
11Nitrogen metabolism_Homo sapiens_hsa009102.34092836
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.31121492
13Base excision repair_Homo sapiens_hsa034102.30194324
14Butanoate metabolism_Homo sapiens_hsa006502.26805161
15RNA transport_Homo sapiens_hsa030132.26177390
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.24016271
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.23746964
18Nicotine addiction_Homo sapiens_hsa050332.20178124
19Pyrimidine metabolism_Homo sapiens_hsa002402.12500622
20Non-homologous end-joining_Homo sapiens_hsa034502.11998872
21Proteasome_Homo sapiens_hsa030502.10121946
22p53 signaling pathway_Homo sapiens_hsa041152.08717244
23Nucleotide excision repair_Homo sapiens_hsa034202.08655950
24Fanconi anemia pathway_Homo sapiens_hsa034602.08285014
25Cell cycle_Homo sapiens_hsa041102.08189335
26Phototransduction_Homo sapiens_hsa047442.07812312
27Tryptophan metabolism_Homo sapiens_hsa003802.04221692
28One carbon pool by folate_Homo sapiens_hsa006702.02700503
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94774237
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88597999
31Primary immunodeficiency_Homo sapiens_hsa053401.78268549
32Fatty acid biosynthesis_Homo sapiens_hsa000611.72586774
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.71156587
34Basal transcription factors_Homo sapiens_hsa030221.71117685
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.62497767
36RNA degradation_Homo sapiens_hsa030181.61878656
37Ether lipid metabolism_Homo sapiens_hsa005651.59760988
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.58284424
39ABC transporters_Homo sapiens_hsa020101.58140714
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56350719
41Herpes simplex infection_Homo sapiens_hsa051681.50300784
42Systemic lupus erythematosus_Homo sapiens_hsa053221.49435740
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46996872
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46817096
45Measles_Homo sapiens_hsa051621.46015173
46Taste transduction_Homo sapiens_hsa047421.35622843
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.33331761
48Caffeine metabolism_Homo sapiens_hsa002321.29858858
49Epstein-Barr virus infection_Homo sapiens_hsa051691.27738071
50Dorso-ventral axis formation_Homo sapiens_hsa043201.24963740
51Morphine addiction_Homo sapiens_hsa050321.22812190
52Antigen processing and presentation_Homo sapiens_hsa046121.21585347
53Hematopoietic cell lineage_Homo sapiens_hsa046401.21486403
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20358848
55Sulfur metabolism_Homo sapiens_hsa009201.18321296
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14944092
57NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14070427
58Serotonergic synapse_Homo sapiens_hsa047261.12910754
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12539599
60Purine metabolism_Homo sapiens_hsa002301.08528343
61Graft-versus-host disease_Homo sapiens_hsa053321.06940370
62Intestinal immune network for IgA production_Homo sapiens_hsa046721.05815986
63Leishmaniasis_Homo sapiens_hsa051401.03947764
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02439102
65mRNA surveillance pathway_Homo sapiens_hsa030151.02337081
66Olfactory transduction_Homo sapiens_hsa047401.01697709
67Viral carcinogenesis_Homo sapiens_hsa052031.01083542
68Legionellosis_Homo sapiens_hsa051340.97437726
69Allograft rejection_Homo sapiens_hsa053300.96502908
70Apoptosis_Homo sapiens_hsa042100.94464466
71Autoimmune thyroid disease_Homo sapiens_hsa053200.94287571
72Protein export_Homo sapiens_hsa030600.94009295
73Glutamatergic synapse_Homo sapiens_hsa047240.90888169
74Chemical carcinogenesis_Homo sapiens_hsa052040.90469440
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88394321
76T cell receptor signaling pathway_Homo sapiens_hsa046600.87315826
77Small cell lung cancer_Homo sapiens_hsa052220.86568800
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86131546
79Folate biosynthesis_Homo sapiens_hsa007900.86088977
80HTLV-I infection_Homo sapiens_hsa051660.85622145
81Propanoate metabolism_Homo sapiens_hsa006400.84736423
82Hepatitis B_Homo sapiens_hsa051610.84678247
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84123439
84GABAergic synapse_Homo sapiens_hsa047270.83760490
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.83614390
86Influenza A_Homo sapiens_hsa051640.83063597
87Malaria_Homo sapiens_hsa051440.82671051
88Lysine degradation_Homo sapiens_hsa003100.82587697
89Calcium signaling pathway_Homo sapiens_hsa040200.82475892
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79980423
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78379871
92Circadian entrainment_Homo sapiens_hsa047130.76498230
93Insulin secretion_Homo sapiens_hsa049110.76400993
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74885625
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73575361
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73551788
97Ovarian steroidogenesis_Homo sapiens_hsa049130.73161573
98Histidine metabolism_Homo sapiens_hsa003400.73156624
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71515545
100TNF signaling pathway_Homo sapiens_hsa046680.70324770
101Glycerolipid metabolism_Homo sapiens_hsa005610.69489638
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68475161
103Asthma_Homo sapiens_hsa053100.67894795
104Retinol metabolism_Homo sapiens_hsa008300.67260917
105Osteoclast differentiation_Homo sapiens_hsa043800.64800594
106Shigellosis_Homo sapiens_hsa051310.64556097
107MicroRNAs in cancer_Homo sapiens_hsa052060.62779568
108B cell receptor signaling pathway_Homo sapiens_hsa046620.61682291
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61618248
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61048598
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60051190
112Cholinergic synapse_Homo sapiens_hsa047250.59277670
113Oxidative phosphorylation_Homo sapiens_hsa001900.58093915
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57780648
115Toxoplasmosis_Homo sapiens_hsa051450.57728500
116Peroxisome_Homo sapiens_hsa041460.56451802
117beta-Alanine metabolism_Homo sapiens_hsa004100.56399242
118Acute myeloid leukemia_Homo sapiens_hsa052210.54978671
119Long-term depression_Homo sapiens_hsa047300.54568254
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.54125126
121Viral myocarditis_Homo sapiens_hsa054160.54043674
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52787365
123Vitamin digestion and absorption_Homo sapiens_hsa049770.51580777
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.51066210
125Steroid biosynthesis_Homo sapiens_hsa001000.48847641
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48745391
127Pertussis_Homo sapiens_hsa051330.48462059
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.47238774
129Type II diabetes mellitus_Homo sapiens_hsa049300.45624044
130Tuberculosis_Homo sapiens_hsa051520.45354461
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43851348
132TGF-beta signaling pathway_Homo sapiens_hsa043500.43762635
133Alcoholism_Homo sapiens_hsa050340.42132086
134Mineral absorption_Homo sapiens_hsa049780.41945886
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41546937
136Melanoma_Homo sapiens_hsa052180.41409271
137Oxytocin signaling pathway_Homo sapiens_hsa049210.39920608
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39337346
139Chronic myeloid leukemia_Homo sapiens_hsa052200.38701691
140Hippo signaling pathway_Homo sapiens_hsa043900.38054902
141Dopaminergic synapse_Homo sapiens_hsa047280.37609600
142Circadian rhythm_Homo sapiens_hsa047100.36626087
143MAPK signaling pathway_Homo sapiens_hsa040100.35999512
144Type I diabetes mellitus_Homo sapiens_hsa049400.35633075
145Salivary secretion_Homo sapiens_hsa049700.35564122
146Pathways in cancer_Homo sapiens_hsa052000.35159437
147Thyroid cancer_Homo sapiens_hsa052160.34710379
148Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34686909
149Regulation of autophagy_Homo sapiens_hsa041400.33823444
150Metabolic pathways_Homo sapiens_hsa011000.33760601
151Colorectal cancer_Homo sapiens_hsa052100.33060973
152Hepatitis C_Homo sapiens_hsa051600.32605084
153Arachidonic acid metabolism_Homo sapiens_hsa005900.32391903
154Prostate cancer_Homo sapiens_hsa052150.32360661
155Pentose phosphate pathway_Homo sapiens_hsa000300.32187406
156Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30470400
157Sulfur relay system_Homo sapiens_hsa041220.30405329
158Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29250553
159Notch signaling pathway_Homo sapiens_hsa043300.27398441
160Leukocyte transendothelial migration_Homo sapiens_hsa046700.26979838
161Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26792687
162Huntingtons disease_Homo sapiens_hsa050160.26756104
163Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26535692
164Salmonella infection_Homo sapiens_hsa051320.25526280
165Sphingolipid metabolism_Homo sapiens_hsa006000.24493091
166Glutathione metabolism_Homo sapiens_hsa004800.24244925
167Selenocompound metabolism_Homo sapiens_hsa004500.24059824
168Pancreatic cancer_Homo sapiens_hsa052120.23789395

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