PDE1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.22018565
2synaptic vesicle exocytosis (GO:0016079)5.88093555
3vocalization behavior (GO:0071625)5.50456697
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.38800523
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.33768089
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.31605460
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.28644757
8nucleobase catabolic process (GO:0046113)5.24163721
9glutamate secretion (GO:0014047)5.22911539
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.20819059
11protein-cofactor linkage (GO:0018065)5.17963939
12protein localization to synapse (GO:0035418)5.17549651
13ionotropic glutamate receptor signaling pathway (GO:0035235)5.10852724
14regulation of glutamate receptor signaling pathway (GO:1900449)5.07983138
15neuron cell-cell adhesion (GO:0007158)4.85312357
16regulation of synaptic vesicle exocytosis (GO:2000300)4.83388743
17glutamate receptor signaling pathway (GO:0007215)4.74690529
18neuron-neuron synaptic transmission (GO:0007270)4.56722852
19synaptic transmission, glutamatergic (GO:0035249)4.51168601
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.46898794
21locomotory exploration behavior (GO:0035641)4.45887431
22regulation of synaptic vesicle transport (GO:1902803)4.39231952
23presynaptic membrane assembly (GO:0097105)4.27429580
24neurotransmitter-gated ion channel clustering (GO:0072578)4.23810653
25synaptic vesicle maturation (GO:0016188)4.22799611
26neuronal action potential propagation (GO:0019227)4.22750328
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.22479574
28gamma-aminobutyric acid signaling pathway (GO:0007214)4.19329051
29establishment of mitochondrion localization (GO:0051654)4.16918777
30cell migration in hindbrain (GO:0021535)4.14951573
31regulation of excitatory postsynaptic membrane potential (GO:0060079)4.13128814
32negative regulation of synaptic transmission, GABAergic (GO:0032229)4.10291392
33long-term synaptic potentiation (GO:0060291)4.08916491
34exploration behavior (GO:0035640)4.04960285
35neuronal ion channel clustering (GO:0045161)4.02856793
36glycosphingolipid biosynthetic process (GO:0006688)3.98917213
37positive regulation of mitochondrial fission (GO:0090141)3.98341919
38positive regulation of neurotransmitter secretion (GO:0001956)3.96343458
39synapse assembly (GO:0007416)3.94216631
40regulation of postsynaptic membrane potential (GO:0060078)3.93475515
41presynaptic membrane organization (GO:0097090)3.93398230
42regulation of neuronal synaptic plasticity (GO:0048168)3.91812740
43neurotransmitter secretion (GO:0007269)3.91364024
44synaptic vesicle endocytosis (GO:0048488)3.91196507
45neuron recognition (GO:0008038)3.89030643
46response to histamine (GO:0034776)3.81964704
47positive regulation of synapse maturation (GO:0090129)3.73645282
48substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.73209450
49substrate-independent telencephalic tangential migration (GO:0021826)3.73209450
50postsynaptic membrane organization (GO:0001941)3.73202472
51regulation of synaptic plasticity (GO:0048167)3.71515098
52positive regulation of membrane potential (GO:0045838)3.70843387
53positive regulation of vesicle fusion (GO:0031340)3.70133134
54dicarboxylic acid catabolic process (GO:0043649)3.69529383
55positive regulation of neurotransmitter transport (GO:0051590)3.62299802
56long-term memory (GO:0007616)3.60645850
57G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.53196033
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52161178
59proline transport (GO:0015824)3.51527324
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50629972
61behavioral defense response (GO:0002209)3.50022857
62behavioral fear response (GO:0001662)3.50022857
63ATP hydrolysis coupled proton transport (GO:0015991)3.48878514
64energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.48878514
65startle response (GO:0001964)3.44853207
66axonal fasciculation (GO:0007413)3.42332502
67G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.41779371
68regulation of glutamate secretion (GO:0014048)3.39877895
69regulation of protein kinase A signaling (GO:0010738)3.39548214
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.39508123
71transferrin transport (GO:0033572)3.39351651
72calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.34622224
73regulation of neurotransmitter secretion (GO:0046928)3.34570406
74regulation of dendritic spine morphogenesis (GO:0061001)3.33595247
75cerebral cortex radially oriented cell migration (GO:0021799)3.32514923
76succinate metabolic process (GO:0006105)3.31950410
77fear response (GO:0042596)3.31919324
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.30225971
79behavioral response to cocaine (GO:0048148)3.30203719
80neurotransmitter transport (GO:0006836)3.30102256
81regulation of synapse structural plasticity (GO:0051823)3.29355139
82long term synaptic depression (GO:0060292)3.25106787
83neurotransmitter biosynthetic process (GO:0042136)3.24812817
84amino acid import (GO:0043090)3.24268599
85C4-dicarboxylate transport (GO:0015740)3.23123158
86regulation of vesicle fusion (GO:0031338)3.21619823
87detection of calcium ion (GO:0005513)3.18295124
88innervation (GO:0060384)3.18146357
89membrane depolarization (GO:0051899)3.18011860
90positive regulation of synaptic transmission (GO:0050806)3.17609757
91trivalent inorganic cation transport (GO:0072512)3.17064063
92ferric iron transport (GO:0015682)3.17064063
93transmission of nerve impulse (GO:0019226)3.15522362
94positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14231531
95dendrite morphogenesis (GO:0048813)3.12764382
96negative regulation of neurotransmitter transport (GO:0051589)3.12572020
97regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.12420139
98dendritic spine morphogenesis (GO:0060997)3.10968239
99regulation of female receptivity (GO:0045924)3.10685420
100behavioral response to ethanol (GO:0048149)3.10526745
101learning (GO:0007612)3.10072426
102serotonin metabolic process (GO:0042428)3.09988272
103regulation of neurotransmitter transport (GO:0051588)3.08879179
104synaptic transmission, dopaminergic (GO:0001963)3.06319650
105regulation of neurotransmitter levels (GO:0001505)3.05440910
106female mating behavior (GO:0060180)3.04909401
107cochlea development (GO:0090102)3.04531591
108regulation of synaptic transmission (GO:0050804)3.03257824
109regulation of synapse maturation (GO:0090128)3.02467198
110synaptic transmission (GO:0007268)3.02417220
111cellular response to ammonium ion (GO:0071242)3.02175960
112positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01054806
113regulation of dendritic spine development (GO:0060998)3.00714653
114positive regulation of dendritic spine morphogenesis (GO:0061003)3.00377664
115synaptic vesicle transport (GO:0048489)3.00362758
116establishment of synaptic vesicle localization (GO:0097480)3.00362758
117positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99932420
118organelle transport along microtubule (GO:0072384)2.98582267
119glycine transport (GO:0015816)2.97664334
120negative regulation of dendrite development (GO:2000171)2.96640198
121gamma-aminobutyric acid transport (GO:0015812)2.92952597
122positive regulation of synapse assembly (GO:0051965)2.91786151
123synapse organization (GO:0050808)2.87967536
124righting reflex (GO:0060013)2.86036814
125calcium ion-dependent exocytosis (GO:0017156)2.85646866
126regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84857061
127chemosensory behavior (GO:0007635)2.84028352
128layer formation in cerebral cortex (GO:0021819)2.83825783
129regulation of voltage-gated calcium channel activity (GO:1901385)2.83230345
130positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.81420736
131regulation of cell communication by electrical coupling (GO:0010649)2.81307038
132acidic amino acid transport (GO:0015800)2.81264312
133establishment of vesicle localization (GO:0051650)2.79711707
134regulation of mitochondrial fission (GO:0090140)2.77352239
135response to dietary excess (GO:0002021)2.76912083
136signal release (GO:0023061)2.70742225
137regulation of synapse assembly (GO:0051963)2.70512519
138positive regulation of amino acid transport (GO:0051957)2.70148694
139social behavior (GO:0035176)2.67769443
140intraspecies interaction between organisms (GO:0051703)2.67769443

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.19120850
2GBX2_23144817_ChIP-Seq_PC3_Human4.57908674
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10281908
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93509964
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90307318
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67611496
7REST_21632747_ChIP-Seq_MESCs_Mouse2.56767561
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53670937
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48514272
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48514272
11TAF15_26573619_Chip-Seq_HEK293_Human2.44092139
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42880556
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37551075
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.34703847
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.32352467
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30828172
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29430663
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27629857
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18035238
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.14981015
21* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10406271
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05193131
23DROSHA_22980978_ChIP-Seq_HELA_Human2.03142516
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02176562
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99759088
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.99675330
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96269219
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.94341789
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.93458447
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92054313
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90341087
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.89780353
33* P300_19829295_ChIP-Seq_ESCs_Human1.88298669
34AR_21572438_ChIP-Seq_LNCaP_Human1.82078428
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79328506
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73846593
37* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70428099
38VDR_22108803_ChIP-Seq_LS180_Human1.69454868
39* FUS_26573619_Chip-Seq_HEK293_Human1.59134182
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56264647
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56136916
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54290148
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.53759134
44ZNF274_21170338_ChIP-Seq_K562_Hela1.53369778
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51761071
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50416418
47AR_25329375_ChIP-Seq_VCAP_Human1.50048233
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49053136
49FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.48564357
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.48349382
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.46297602
52* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42725397
53* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40532290
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38080857
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37601062
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37393526
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32535349
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.31615985
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.31209384
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.31153642
61* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30820192
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28756038
63STAT3_23295773_ChIP-Seq_U87_Human1.28545706
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28313210
65EWS_26573619_Chip-Seq_HEK293_Human1.27711361
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.25425445
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24991439
68ER_23166858_ChIP-Seq_MCF-7_Human1.20552835
69* TCF4_23295773_ChIP-Seq_U87_Human1.20451422
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18735562
71RNF2_27304074_Chip-Seq_NSC_Mouse1.18721391
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18123654
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17899865
74* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16001929
75JUN_21703547_ChIP-Seq_K562_Human1.15953428
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15605888
77TP53_16413492_ChIP-PET_HCT116_Human1.15458222
78TP53_18474530_ChIP-ChIP_U2OS_Human1.15070271
79* NANOG_18555785_Chip-Seq_ESCs_Mouse1.13646357
80* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11887421
81RUNX2_22187159_ChIP-Seq_PCA_Human1.11816675
82IGF1R_20145208_ChIP-Seq_DFB_Human1.11644720
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.10682820
84BCAT_22108803_ChIP-Seq_LS180_Human1.10463875
85AR_19668381_ChIP-Seq_PC3_Human1.10289016
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.10153568
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08869985
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07917817
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07249297
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.05153070
91KDM2B_26808549_Chip-Seq_REH_Human1.05033694
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.04262448
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03912123
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03804281
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01950441
96SOX9_26525672_Chip-Seq_HEART_Mouse1.01823232
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00705956
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.00573526
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00541705
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99637767
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99637767
102LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99279730
103RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99055824
104P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98177278
105* E2F1_18555785_Chip-Seq_ESCs_Mouse0.97776736
106* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97734279
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97706813
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96602089
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96093504
110AHR_22903824_ChIP-Seq_MCF-7_Human0.95771028
111CBP_20019798_ChIP-Seq_JUKART_Human0.94723788
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94723788
113* P53_22387025_ChIP-Seq_ESCs_Mouse0.94627637
114SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93207313
115* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91973655
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91969561
117FLI1_21867929_ChIP-Seq_TH2_Mouse0.91625124
118* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91362380
119TAL1_26923725_Chip-Seq_HPCs_Mouse0.90740603
120PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89234592

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.21404475
2MP0003880_abnormal_central_pattern5.69014621
3MP0003635_abnormal_synaptic_transmissio4.18918180
4MP0009745_abnormal_behavioral_response3.55773226
5MP0002063_abnormal_learning/memory/cond3.47415273
6MP0001968_abnormal_touch/_nociception3.45775301
7MP0004270_analgesia3.43794063
8MP0002064_seizures3.31811785
9MP0002736_abnormal_nociception_after3.30606481
10MP0002572_abnormal_emotion/affect_behav3.05391435
11MP0009046_muscle_twitch2.92697081
12MP0001501_abnormal_sleep_pattern2.67649357
13MP0002272_abnormal_nervous_system2.65577990
14MP0001440_abnormal_grooming_behavior2.48050659
15MP0002735_abnormal_chemical_nociception2.48038225
16MP0002734_abnormal_mechanical_nocicepti2.43958403
17MP0001486_abnormal_startle_reflex2.37756347
18MP0009780_abnormal_chondrocyte_physiolo2.03432698
19MP0002067_abnormal_sensory_capabilities2.01671765
20MP0001986_abnormal_taste_sensitivity1.97376668
21MP0002837_dystrophic_cardiac_calcinosis1.97099938
22MP0001529_abnormal_vocalization1.87507443
23MP0001970_abnormal_pain_threshold1.81542103
24MP0006276_abnormal_autonomic_nervous1.80306415
25MP0003879_abnormal_hair_cell1.77921267
26MP0003787_abnormal_imprinting1.76507731
27MP0002733_abnormal_thermal_nociception1.74581736
28MP0002822_catalepsy1.74334162
29MP0005386_behavior/neurological_phenoty1.70814504
30MP0004924_abnormal_behavior1.70814504
31MP0005423_abnormal_somatic_nervous1.67057622
32MP0000778_abnormal_nervous_system1.66546890
33MP0005646_abnormal_pituitary_gland1.63927027
34MP0002557_abnormal_social/conspecific_i1.63506198
35MP0002184_abnormal_innervation1.61626858
36MP0001984_abnormal_olfaction1.59968663
37MP0004858_abnormal_nervous_system1.59624421
38MP0003329_amyloid_beta_deposits1.57485584
39MP0004811_abnormal_neuron_physiology1.55644392
40MP0002102_abnormal_ear_morphology1.53913514
41MP0001270_distended_abdomen1.51462610
42MP0001905_abnormal_dopamine_level1.51450872
43MP0001188_hyperpigmentation1.51288527
44MP0005645_abnormal_hypothalamus_physiol1.45356032
45MP0008569_lethality_at_weaning1.44728980
46MP0003121_genomic_imprinting1.44255859
47MP0002876_abnormal_thyroid_physiology1.38235049
48MP0003122_maternal_imprinting1.34370350
49MP0002066_abnormal_motor_capabilities/c1.31841311
50MP0002909_abnormal_adrenal_gland1.27442709
51MP0003633_abnormal_nervous_system1.25525452
52MP0004484_altered_response_of1.23737886
53MP0000955_abnormal_spinal_cord1.23567881
54MP0002882_abnormal_neuron_morphology1.20797213
55MP0003646_muscle_fatigue1.16435753
56MP0008872_abnormal_physiological_respon1.12880099
57MP0000751_myopathy1.11614391
58MP0000049_abnormal_middle_ear1.10031030
59MP0004142_abnormal_muscle_tone1.09171170
60MP0001502_abnormal_circadian_rhythm1.08919466
61MP0008789_abnormal_olfactory_epithelium1.08867066
62MP0004147_increased_porphyrin_level1.06933738
63MP0003631_nervous_system_phenotype1.05188908
64MP0003385_abnormal_body_wall1.05057741
65MP0008874_decreased_physiological_sensi1.03230556
66MP0004043_abnormal_pH_regulation0.98328001
67MP0002234_abnormal_pharynx_morphology0.98175685
68MP0002332_abnormal_exercise_endurance0.97678251
69MP0005535_abnormal_body_temperature0.96519684
70MP0001664_abnormal_digestion0.96502198
71MP0002751_abnormal_autonomic_nervous0.95017501
72MP0002152_abnormal_brain_morphology0.94359830
73MP0010386_abnormal_urinary_bladder0.93560506
74MP0000013_abnormal_adipose_tissue0.93530974
75MP0002069_abnormal_eating/drinking_beha0.93530890
76MP0000569_abnormal_digit_pigmentation0.91935848
77MP0002638_abnormal_pupillary_reflex0.89041231
78MP0001299_abnormal_eye_distance/0.88289693
79MP0001963_abnormal_hearing_physiology0.87231264
80MP0005253_abnormal_eye_physiology0.87101434
81MP0000920_abnormal_myelination0.86732250
82MP0004215_abnormal_myocardial_fiber0.86639040
83MP0004233_abnormal_muscle_weight0.86332585
84MP0005410_abnormal_fertilization0.86143697
85MP0005551_abnormal_eye_electrophysiolog0.86082803
86MP0004885_abnormal_endolymph0.85553367
87MP0004085_abnormal_heartbeat0.85444488
88MP0000516_abnormal_urinary_system0.84361802
89MP0005367_renal/urinary_system_phenotyp0.84361802
90MP0003221_abnormal_cardiomyocyte_apopto0.82108426
91MP0005171_absent_coat_pigmentation0.80940608
92MP0004145_abnormal_muscle_electrophysio0.80665972
93MP0003938_abnormal_ear_development0.78403049
94MP0004742_abnormal_vestibular_system0.76283686
95MP0002229_neurodegeneration0.74956294
96MP0002653_abnormal_ependyma_morphology0.73550372
97MP0003137_abnormal_impulse_conducting0.73456221
98MP0005394_taste/olfaction_phenotype0.69732779
99MP0005499_abnormal_olfactory_system0.69732779
100MP0008004_abnormal_stomach_pH0.69472236
101MP0003861_abnormal_nervous_system0.68857587
102MP0001765_abnormal_ion_homeostasis0.67914466
103MP0004510_myositis0.67556471
104MP0001177_atelectasis0.67307669
105MP0003690_abnormal_glial_cell0.65027071
106MP0008995_early_reproductive_senescence0.64953714
107MP0000604_amyloidosis0.64615871
108MP0003183_abnormal_peptide_metabolism0.64151310
109MP0003075_altered_response_to0.63503963
110MP0000750_abnormal_muscle_regeneration0.63040553
111MP0008877_abnormal_DNA_methylation0.62917793
112MP0000631_abnormal_neuroendocrine_gland0.62530727
113MP0005409_darkened_coat_color0.61119248
114MP0002752_abnormal_somatic_nervous0.60605935
115MP0005167_abnormal_blood-brain_barrier0.57465067
116MP0003632_abnormal_nervous_system0.56833679
117MP0000026_abnormal_inner_ear0.54137739
118MP0005623_abnormal_meninges_morphology0.52135061
119MP0004036_abnormal_muscle_relaxation0.52101533
120MP0001943_abnormal_respiration0.51025223
121MP0005620_abnormal_muscle_contractility0.50913372
122MP0005187_abnormal_penis_morphology0.50572949
123MP0003634_abnormal_glial_cell0.50464480
124MP0005595_abnormal_vascular_smooth0.49342851
125MP0001485_abnormal_pinna_reflex0.46183816
126MP0006292_abnormal_olfactory_placode0.46136054

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.72975635
2Focal seizures (HP:0007359)5.94882997
3Epileptic encephalopathy (HP:0200134)5.81254427
4Myokymia (HP:0002411)5.51994218
5Hyperventilation (HP:0002883)5.41572830
6Visual hallucinations (HP:0002367)5.31262043
7Atonic seizures (HP:0010819)5.23609021
8Febrile seizures (HP:0002373)4.70889607
9Absence seizures (HP:0002121)4.56902476
10Dialeptic seizures (HP:0011146)4.32153518
11Generalized tonic-clonic seizures (HP:0002069)4.10448493
12Progressive cerebellar ataxia (HP:0002073)3.98741406
13Broad-based gait (HP:0002136)3.80143007
14Limb dystonia (HP:0002451)3.64507898
15Amblyopia (HP:0000646)3.53878745
16Amyotrophic lateral sclerosis (HP:0007354)3.53543195
17Impaired vibration sensation in the lower limbs (HP:0002166)3.48875349
18Spastic tetraplegia (HP:0002510)3.37651888
19Spastic diplegia (HP:0001264)3.24344970
20Gaze-evoked nystagmus (HP:0000640)3.21306506
21Lissencephaly (HP:0001339)3.18511156
22Epileptiform EEG discharges (HP:0011182)3.06248954
23Poor eye contact (HP:0000817)3.05568114
24Drooling (HP:0002307)3.02211797
25Excessive salivation (HP:0003781)3.02211797
26Cerebral inclusion bodies (HP:0100314)2.99970543
27Truncal ataxia (HP:0002078)2.98188120
28Absent speech (HP:0001344)2.96804911
29Hepatoblastoma (HP:0002884)2.91504169
30Abnormal eating behavior (HP:0100738)2.88546119
31Anxiety (HP:0000739)2.87359622
32Absent/shortened dynein arms (HP:0200106)2.86959508
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.86959508
34Upper limb muscle weakness (HP:0003484)2.83891053
35Split foot (HP:0001839)2.83355095
36Dysmetria (HP:0001310)2.79433867
37Dysdiadochokinesis (HP:0002075)2.73854940
38Abnormality of the labia minora (HP:0012880)2.73002433
39Peripheral hypomyelination (HP:0007182)2.70442347
40Depression (HP:0000716)2.70235458
41Polyphagia (HP:0002591)2.68489766
42Lower limb muscle weakness (HP:0007340)2.66219792
43Unilateral renal agenesis (HP:0000122)2.65465141
44Abnormal social behavior (HP:0012433)2.64789644
45Impaired social interactions (HP:0000735)2.64789644
46Urinary bladder sphincter dysfunction (HP:0002839)2.62363182
47Diplopia (HP:0000651)2.61470870
48Abnormality of binocular vision (HP:0011514)2.61470870
49EEG with generalized epileptiform discharges (HP:0011198)2.61051643
50Protruding tongue (HP:0010808)2.58724671
51Impaired smooth pursuit (HP:0007772)2.55088193
52Poor suck (HP:0002033)2.51830451
53Supranuclear gaze palsy (HP:0000605)2.51213016
54Action tremor (HP:0002345)2.50743850
55Thyroid-stimulating hormone excess (HP:0002925)2.50081151
56Pachygyria (HP:0001302)2.49463971
57Inability to walk (HP:0002540)2.49277382
58Delusions (HP:0000746)2.47537793
59Gait imbalance (HP:0002141)2.45798733
60Impaired vibratory sensation (HP:0002495)2.45740787
61Termporal pattern (HP:0011008)2.45120708
62Insidious onset (HP:0003587)2.45120708
63Clonus (HP:0002169)2.41243843
64Type II lissencephaly (HP:0007260)2.41173987
65Dysmetric saccades (HP:0000641)2.40654722
66Genital tract atresia (HP:0001827)2.40616194
67Hypsarrhythmia (HP:0002521)2.39026528
68Cerebral hypomyelination (HP:0006808)2.38871021
69Postural instability (HP:0002172)2.38734416
70Abnormal hair whorl (HP:0010721)2.38102428
71Vaginal atresia (HP:0000148)2.37381643
72Abnormality of the musculature of the pelvis (HP:0001469)2.37070652
73Abnormality of the hip-girdle musculature (HP:0001445)2.37070652
74Pheochromocytoma (HP:0002666)2.34500436
75Medial flaring of the eyebrow (HP:0010747)2.33745424
76Bradykinesia (HP:0002067)2.29738110
77Fetal akinesia sequence (HP:0001989)2.29711133
78Generalized myoclonic seizures (HP:0002123)2.28171091
79Congenital primary aphakia (HP:0007707)2.22727606
80Status epilepticus (HP:0002133)2.22148338
81Blue irides (HP:0000635)2.21976700
82Hemiparesis (HP:0001269)2.17690719
83Nephrogenic diabetes insipidus (HP:0009806)2.16752628
84Fair hair (HP:0002286)2.14720521
85Progressive inability to walk (HP:0002505)2.14556182
86Hypoplasia of the corpus callosum (HP:0002079)2.14337271
87Neuroendocrine neoplasm (HP:0100634)2.14060855
88Abnormality of ocular smooth pursuit (HP:0000617)2.13739939
89Abnormality of the lower motor neuron (HP:0002366)2.12215271
90Scanning speech (HP:0002168)2.12163159
91Urinary urgency (HP:0000012)2.12032217
92Esotropia (HP:0000565)2.11994265
93Neurofibrillary tangles (HP:0002185)2.10759309
94Resting tremor (HP:0002322)2.10035849
95Acute necrotizing encephalopathy (HP:0006965)2.06915698
96Decreased lacrimation (HP:0000633)2.05059223
97Shoulder girdle muscle weakness (HP:0003547)2.04989844
98Focal dystonia (HP:0004373)2.04840890
99Broad alveolar ridges (HP:0000187)2.04780098
100Stereotypic behavior (HP:0000733)2.04717298
101Cortical dysplasia (HP:0002539)2.04271479
102Incomplete penetrance (HP:0003829)2.03943404
103Genetic anticipation (HP:0003743)2.03596360
104Abnormality of the corticospinal tract (HP:0002492)2.03576583
105Abnormality of salivation (HP:0100755)2.03171307
106Abnormal mitochondria in muscle tissue (HP:0008316)2.01612743
107Generalized hypopigmentation of hair (HP:0011358)2.00564058
108Aplasia/Hypoplasia of the brainstem (HP:0007362)2.00539116
109Hypoplasia of the brainstem (HP:0002365)2.00539116
110Poor coordination (HP:0002370)2.00395936
111Decreased testicular size (HP:0008734)1.99854935
112Intention tremor (HP:0002080)1.99015528
113Optic nerve hypoplasia (HP:0000609)1.98878792
114Atrophy/Degeneration involving motor neurons (HP:0007373)1.98129508
115Intellectual disability, severe (HP:0010864)1.96453917
116Degeneration of the lateral corticospinal tracts (HP:0002314)1.96004801
117Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96004801
118Retinal dysplasia (HP:0007973)1.95326138
119Ankle clonus (HP:0011448)1.95296935
120Progressive macrocephaly (HP:0004481)1.95279098
121Psychosis (HP:0000709)1.94966485
122Abnormal ciliary motility (HP:0012262)1.94781656
123Ulnar claw (HP:0001178)1.94387541
124Hyperthyroidism (HP:0000836)1.94181365
125Gait ataxia (HP:0002066)1.91084728
126Muscular hypotonia of the trunk (HP:0008936)1.90302710
127Spastic gait (HP:0002064)1.90263843
128Oligomenorrhea (HP:0000876)1.90134034
129Paraplegia (HP:0010550)1.89690042
130Torticollis (HP:0000473)1.88886012
131Dyskinesia (HP:0100660)1.87310264
132Failure to thrive in infancy (HP:0001531)1.87190760
133Specific learning disability (HP:0001328)1.86856325
134Narrow nasal bridge (HP:0000446)1.84823261
135Cholecystitis (HP:0001082)1.84243542
136Abnormal gallbladder physiology (HP:0012438)1.84243542
137Thickened helices (HP:0000391)1.84218849
138Mutism (HP:0002300)1.83394796
139Alacrima (HP:0000522)1.82308912
140Hypoventilation (HP:0002791)1.80934818
141Intellectual disability, progressive (HP:0006887)1.80094247
142Abnormal respiratory motile cilium morphology (HP:0005938)1.79967236
143Abnormal respiratory epithelium morphology (HP:0012253)1.79967236
144Morphological abnormality of the pyramidal tract (HP:0002062)1.79519715
145CNS hypomyelination (HP:0003429)1.78142184
146Increased circulating renin level (HP:0000848)1.76296643
147Spastic paraplegia (HP:0001258)1.75232359

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.59571001
2NTRK34.00495719
3CASK3.82727618
4MAP3K43.56679578
5MAP3K123.45726452
6MAP2K73.39504254
7RIPK43.20667668
8TRIM282.93642489
9CDK192.64201736
10PLK22.59321991
11MAP3K92.59030495
12DAPK22.40228454
13EPHA32.28510908
14MAP2K42.28121590
15DAPK12.24431549
16MINK12.21963689
17STK38L1.95619619
18MAP4K21.81311753
19PTK2B1.77749548
20OXSR11.74919387
21GRK51.73946412
22PRPF4B1.71876285
23BMPR21.64977900
24PNCK1.63502512
25CSNK1A1L1.62771360
26MARK11.61062644
27CSNK1G31.55223332
28FRK1.53012878
29DYRK21.43523588
30PAK61.40389433
31KSR11.39777809
32ARAF1.37094447
33AKT31.32940056
34NME11.30923007
35NTRK21.30055408
36CDK51.28359774
37ERBB31.26914089
38PRKCG1.26756625
39CAMK2A1.24727754
40KSR21.22162220
41CSNK1G11.17849117
42RPS6KA41.17368965
43FGR1.11389625
44TNIK1.10422478
45FES1.09384554
46PDK41.09269254
47PDK31.09269254
48MAP3K131.07540089
49MAPK131.04033995
50CAMK2B1.02523731
51SIK31.02217801
52CAMKK11.01636501
53PRKD31.00628304
54SIK21.00546935
55NTRK10.98794552
56CCNB10.95489738
57PHKG20.91303912
58PHKG10.91303912
59GRK70.88230979
60CAMK10.84172595
61STK380.84092510
62CAMKK20.82271221
63SGK2230.78872588
64SGK4940.78872588
65GRK60.78691975
66WNK30.77552819
67SGK20.76674849
68CDK180.75539345
69RAF10.73716133
70FGFR20.72764270
71LIMK10.72620899
72TESK10.72317039
73FER0.71666834
74BRD40.71224475
75CDK140.69631755
76CDK150.69520914
77DYRK1A0.68157764
78SGK10.66460071
79SRPK10.64748057
80PKN10.64416292
81BRAF0.64298341
82PRKCE0.63989067
83PDK10.62394198
84TAOK10.61972079
85TSSK60.61267257
86MAP3K60.60169470
87INSRR0.59644059
88CDK11A0.58895966
89MYLK0.58638881
90STK110.57785742
91PDK20.56741016
92ADRBK10.55408456
93CAMK2D0.53621584
94PDPK10.53391400
95UHMK10.52842290
96MAP3K20.52141854
97DAPK30.51835463
98LATS20.49331916
99CSNK1D0.49181372
100BCR0.48711983
101ADRBK20.48030137
102PAK30.47915175
103DYRK1B0.45695538
104PIM20.45648324
105CAMK40.43220313
106SGK30.43196593
107CSNK1A10.42941963
108MAP3K50.41740431
109MAP2K10.41189042
110TYRO30.41176884
111PRKCH0.38988429
112CAMK2G0.38769645
113ROCK20.38520322
114PRKACB0.38195858
115RET0.37169049
116TNK20.37168318
117LMTK20.36876179
118MAPK100.36842592
119PRKAA10.34395074
120MARK20.34305636
121MAP3K10.33972048
122PRKCZ0.33384711
123MAPK90.32741783
124WNK40.32384506
125PRKD10.32347382
126CSNK1G20.31308999
127PRKG10.31292480
128PLK30.30807516
129PINK10.30361444
130IRAK20.29942725
131RPS6KA30.29860491
132FYN0.29732415
133MAP3K70.29613219
134PRKACA0.29440438
135PRKD20.28477703
136DYRK30.27796753
137PRKACG0.26406953

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.31063897
2Synaptic vesicle cycle_Homo sapiens_hsa047213.62845088
3Long-term potentiation_Homo sapiens_hsa047202.95231246
4Collecting duct acid secretion_Homo sapiens_hsa049662.94211171
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.89925095
6Circadian entrainment_Homo sapiens_hsa047132.76482884
7Amphetamine addiction_Homo sapiens_hsa050312.73598337
8Glutamatergic synapse_Homo sapiens_hsa047242.54498658
9GABAergic synapse_Homo sapiens_hsa047272.48609640
10* Morphine addiction_Homo sapiens_hsa050322.41499582
11Salivary secretion_Homo sapiens_hsa049702.35937389
12* Olfactory transduction_Homo sapiens_hsa047402.21849442
13Dopaminergic synapse_Homo sapiens_hsa047282.12362048
14Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.04722996
15Butanoate metabolism_Homo sapiens_hsa006502.00073522
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99527576
17Insulin secretion_Homo sapiens_hsa049111.91417534
18Gastric acid secretion_Homo sapiens_hsa049711.87304686
19* Taste transduction_Homo sapiens_hsa047421.80665968
20* Renin secretion_Homo sapiens_hsa049241.79065392
21Long-term depression_Homo sapiens_hsa047301.78404846
22* Calcium signaling pathway_Homo sapiens_hsa040201.77399248
23Serotonergic synapse_Homo sapiens_hsa047261.77239530
24Vibrio cholerae infection_Homo sapiens_hsa051101.73492138
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71132409
26Oxytocin signaling pathway_Homo sapiens_hsa049211.62475161
27Cholinergic synapse_Homo sapiens_hsa047251.59317260
28Oxidative phosphorylation_Homo sapiens_hsa001901.47893589
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39532403
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.37225610
31beta-Alanine metabolism_Homo sapiens_hsa004101.33265303
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32703185
33Cocaine addiction_Homo sapiens_hsa050301.29605476
34cAMP signaling pathway_Homo sapiens_hsa040241.26594186
35GnRH signaling pathway_Homo sapiens_hsa049121.26280263
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21906117
37Alzheimers disease_Homo sapiens_hsa050101.21436626
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20740382
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20623452
40Gap junction_Homo sapiens_hsa045401.20064989
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14730334
42Cardiac muscle contraction_Homo sapiens_hsa042601.13176067
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09215785
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03623932
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98544763
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96610813
47Axon guidance_Homo sapiens_hsa043600.95765611
48Estrogen signaling pathway_Homo sapiens_hsa049150.94964420
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.94511939
50Phototransduction_Homo sapiens_hsa047440.94280758
51Glioma_Homo sapiens_hsa052140.92842512
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92634274
53Melanogenesis_Homo sapiens_hsa049160.91704792
54Type II diabetes mellitus_Homo sapiens_hsa049300.88791580
55ErbB signaling pathway_Homo sapiens_hsa040120.84138813
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83097728
57Rheumatoid arthritis_Homo sapiens_hsa053230.82732461
58Parkinsons disease_Homo sapiens_hsa050120.81555577
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77584268
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76755651
61Pancreatic secretion_Homo sapiens_hsa049720.73802982
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72969166
63Protein export_Homo sapiens_hsa030600.72270207
64Glucagon signaling pathway_Homo sapiens_hsa049220.72255278
65African trypanosomiasis_Homo sapiens_hsa051430.70747355
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70606876
67Thyroid hormone synthesis_Homo sapiens_hsa049180.68684791
68Oocyte meiosis_Homo sapiens_hsa041140.68498543
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66448470
70Huntingtons disease_Homo sapiens_hsa050160.64146921
71Fatty acid biosynthesis_Homo sapiens_hsa000610.63768044
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59911442
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59017826
74MAPK signaling pathway_Homo sapiens_hsa040100.58219324
75Dilated cardiomyopathy_Homo sapiens_hsa054140.57891995
76Choline metabolism in cancer_Homo sapiens_hsa052310.57845132
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57271214
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54827883
79Regulation of autophagy_Homo sapiens_hsa041400.54491401
80Ras signaling pathway_Homo sapiens_hsa040140.53888475
81AMPK signaling pathway_Homo sapiens_hsa041520.53523887
82Ether lipid metabolism_Homo sapiens_hsa005650.51798117
83Phagosome_Homo sapiens_hsa041450.48927156
84VEGF signaling pathway_Homo sapiens_hsa043700.47733506
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47730928
86Inositol phosphate metabolism_Homo sapiens_hsa005620.47117545
87Dorso-ventral axis formation_Homo sapiens_hsa043200.46823109
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46471630
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44315651
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.44006948
91Type I diabetes mellitus_Homo sapiens_hsa049400.42386473
92Rap1 signaling pathway_Homo sapiens_hsa040150.42136501
93Pyruvate metabolism_Homo sapiens_hsa006200.36710175
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35954971
95Steroid biosynthesis_Homo sapiens_hsa001000.33449423
96Wnt signaling pathway_Homo sapiens_hsa043100.32782618
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.30911263
98Hedgehog signaling pathway_Homo sapiens_hsa043400.29614884
99Circadian rhythm_Homo sapiens_hsa047100.29314730
100Linoleic acid metabolism_Homo sapiens_hsa005910.29297833
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28691743
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28679012
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28450296
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28032877
105Alcoholism_Homo sapiens_hsa050340.26914386
106ABC transporters_Homo sapiens_hsa020100.26732420
107Hippo signaling pathway_Homo sapiens_hsa043900.26218375
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.26179282
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25689853
110Arginine and proline metabolism_Homo sapiens_hsa003300.25596734
111Peroxisome_Homo sapiens_hsa041460.25329103
112Prion diseases_Homo sapiens_hsa050200.24925744
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24715731
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23924700
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23477691
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23239755
117Bile secretion_Homo sapiens_hsa049760.23090616
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21934270
119Arginine biosynthesis_Homo sapiens_hsa002200.19599027
120Insulin signaling pathway_Homo sapiens_hsa049100.19527129
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19337537
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18791568
123Ovarian steroidogenesis_Homo sapiens_hsa049130.17417079
124Mineral absorption_Homo sapiens_hsa049780.17407689
125Endocytosis_Homo sapiens_hsa041440.16685692

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