PDE1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.62365894
2axonemal dynein complex assembly (GO:0070286)4.44471322
3sensory perception of smell (GO:0007608)4.40605781
4acrosome reaction (GO:0007340)4.33908795
5acrosome assembly (GO:0001675)4.29236785
6cardiac myofibril assembly (GO:0055003)4.16339199
7sarcomere organization (GO:0045214)4.11927998
8piRNA metabolic process (GO:0034587)4.08111070
9membrane depolarization during action potential (GO:0086010)4.03360210
10detection of calcium ion (GO:0005513)3.99162020
11cardiac muscle contraction (GO:0060048)3.94194282
12regulation of actin filament-based movement (GO:1903115)3.93039701
13regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.92757113
14sperm motility (GO:0030317)3.86642926
15response to pheromone (GO:0019236)3.86465079
16protein localization to cilium (GO:0061512)3.85672075
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.85608456
18fusion of sperm to egg plasma membrane (GO:0007342)3.79272116
19cellular potassium ion homeostasis (GO:0030007)3.71795257
20cilium movement (GO:0003341)3.71787479
21epithelial cilium movement (GO:0003351)3.70463706
22G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.69276814
23positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.67872176
24regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.64858967
25synaptic vesicle docking involved in exocytosis (GO:0016081)3.64058646
26positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.63769649
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.63604695
28negative regulation of cytosolic calcium ion concentration (GO:0051481)3.60570677
29neuron cell-cell adhesion (GO:0007158)3.59439721
30positive regulation of potassium ion transmembrane transport (GO:1901381)3.56992595
31calcium ion-dependent exocytosis (GO:0017156)3.56657986
32cell communication involved in cardiac conduction (GO:0086065)3.55722224
33multicellular organism reproduction (GO:0032504)3.55620190
34regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.53428226
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51692710
36detection of light stimulus involved in sensory perception (GO:0050962)3.50059458
37detection of light stimulus involved in visual perception (GO:0050908)3.50059458
38regulation of the force of heart contraction (GO:0002026)3.48976794
39axon ensheathment in central nervous system (GO:0032291)3.48972342
40central nervous system myelination (GO:0022010)3.48972342
41regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.48095223
42protein polyglutamylation (GO:0018095)3.46138767
43positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.44502932
44regulation of membrane repolarization (GO:0060306)3.42752612
45myofibril assembly (GO:0030239)3.39300423
46sperm capacitation (GO:0048240)3.38889633
47regulation of cilium movement (GO:0003352)3.38441543
48cerebellar Purkinje cell differentiation (GO:0021702)3.37537043
49regulation of cardiac muscle cell contraction (GO:0086004)3.36522536
50potassium ion export (GO:0071435)3.34854916
51regulation of cell communication by electrical coupling (GO:0010649)3.34287056
52cell communication by electrical coupling (GO:0010644)3.34166873
53urinary tract smooth muscle contraction (GO:0014848)3.32435705
54regulation of short-term neuronal synaptic plasticity (GO:0048172)3.32279271
55glutamate secretion (GO:0014047)3.27829404
56neuronal action potential (GO:0019228)3.24860245
57plasma membrane fusion (GO:0045026)3.24207199
58cellular response to epinephrine stimulus (GO:0071872)3.23698013
59ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.14858906
60negative regulation of protein localization to cell surface (GO:2000009)3.14111784
61positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.13441339
62male meiosis (GO:0007140)3.12252785
63sensory perception of chemical stimulus (GO:0007606)3.11926160
64potassium ion homeostasis (GO:0055075)3.10944203
65regulation of striated muscle contraction (GO:0006942)3.10781149
66actomyosin structure organization (GO:0031032)3.10624973
67regulation of cardiac muscle contraction (GO:0055117)3.09199087
68positive regulation of potassium ion transport (GO:0043268)3.08164243
69actin-myosin filament sliding (GO:0033275)3.07703228
70muscle filament sliding (GO:0030049)3.07703228
71negative regulation of inclusion body assembly (GO:0090084)3.07094359
72negative regulation of potassium ion transmembrane transport (GO:1901380)3.04767266
73calcium ion import (GO:0070509)3.03636000
74sperm-egg recognition (GO:0035036)3.02763851
75regulation of synaptic vesicle exocytosis (GO:2000300)3.02527786
76sodium ion export (GO:0071436)3.01369898
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99612436
78cardiac muscle cell development (GO:0055013)2.98208438
79actin-mediated cell contraction (GO:0070252)2.97826719
80membrane repolarization (GO:0086009)2.97595718
81neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.97347206
82response to epinephrine (GO:0071871)2.97145432
83motile cilium assembly (GO:0044458)2.94216914
84regulation of relaxation of muscle (GO:1901077)2.92936387
85membrane hyperpolarization (GO:0060081)2.92129018
86endocardial cushion development (GO:0003197)2.91968445
87sarcoplasmic reticulum calcium ion transport (GO:0070296)2.91672233
88cardiac muscle hypertrophy (GO:0003300)2.91241243
89regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.90342262
90cardiac muscle tissue morphogenesis (GO:0055008)2.89085336
91astrocyte development (GO:0014002)2.88622697
92negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.88523194
93heparin metabolic process (GO:0030202)2.87817081
94heparin biosynthetic process (GO:0030210)2.87817081
95axoneme assembly (GO:0035082)2.86945522
96relaxation of cardiac muscle (GO:0055119)2.86603374
97neuronal ion channel clustering (GO:0045161)2.84165091
98regulation of heart rate by cardiac conduction (GO:0086091)2.83103675
99positive regulation of action potential (GO:0045760)2.82394411
100negative regulation of dendrite development (GO:2000171)2.82140105
101cardiac cell development (GO:0055006)2.81932184
102ventricular cardiac muscle cell action potential (GO:0086005)2.81602545
103regulation of synapse structural plasticity (GO:0051823)2.79937912
104reproduction (GO:0000003)2.79676237
105negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79417940
106collagen fibril organization (GO:0030199)2.78191233
107positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.76965029
108synaptic vesicle maturation (GO:0016188)2.76546531
109eye photoreceptor cell differentiation (GO:0001754)2.76441743
110photoreceptor cell differentiation (GO:0046530)2.76441743
111cardiac conduction (GO:0061337)2.75951061
112regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.75247219
113neurotransmitter-gated ion channel clustering (GO:0072578)2.74500792
114positive regulation of synapse maturation (GO:0090129)2.73701711
115glutamate receptor signaling pathway (GO:0007215)2.73677589
116striated muscle hypertrophy (GO:0014897)2.72764155
117mating behavior (GO:0007617)2.72639369
118muscle tissue morphogenesis (GO:0060415)2.71799012
119regulation of calcium ion transmembrane transport (GO:1903169)2.70818440
120regulation of calcium ion transmembrane transporter activity (GO:1901019)2.70818440
121central nervous system projection neuron axonogenesis (GO:0021952)2.70640849
122cell migration involved in heart development (GO:0060973)2.70467950
123cerebellar granule cell differentiation (GO:0021707)2.70309953
124synaptic vesicle exocytosis (GO:0016079)2.69813497
125cell-cell recognition (GO:0009988)2.69688705
126protein localization to synapse (GO:0035418)2.68630418
127dendrite morphogenesis (GO:0048813)2.67256756
128regulation of heart rate (GO:0002027)2.67133592
129spermatid development (GO:0007286)2.65762219
130cell wall macromolecule metabolic process (GO:0044036)2.64735920
131cell wall macromolecule catabolic process (GO:0016998)2.64735920
132regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.63997564
133regulation of potassium ion transmembrane transport (GO:1901379)2.63549761
134striatum development (GO:0021756)2.63260212
135nonmotile primary cilium assembly (GO:0035058)2.63187883
136regulation of synaptic vesicle transport (GO:1902803)2.62537686
137neuronal action potential propagation (GO:0019227)2.62374861
138cellular response to catecholamine stimulus (GO:0071870)2.62104933
139cellular response to monoamine stimulus (GO:0071868)2.62104933
140single fertilization (GO:0007338)2.61313911
141axonal fasciculation (GO:0007413)2.61100514
142action potential (GO:0001508)2.60790131
143vocalization behavior (GO:0071625)2.60359495
144negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.60071243
145relaxation of smooth muscle (GO:0044557)2.58446361
146striated muscle contraction (GO:0006941)2.58261855
147positive regulation of cardiac muscle cell differentiation (GO:2000727)2.57829166
148positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.57351159
149relaxation of muscle (GO:0090075)2.56960971
150calcium-mediated signaling using intracellular calcium source (GO:0035584)2.54577960
151chondrocyte proliferation (GO:0035988)2.54012656
152regulation of heart contraction (GO:0008016)2.53493436
153extracellular matrix assembly (GO:0085029)2.48442387
154positive regulation of cation channel activity (GO:2001259)2.47190179
155actin filament depolymerization (GO:0030042)2.46837301
156activation of protein kinase A activity (GO:0034199)2.46204420
157positive regulation of heart rate (GO:0010460)2.45610692
158response to monoamine (GO:0071867)2.42334939
159response to catecholamine (GO:0071869)2.42334939
160gamma-aminobutyric acid signaling pathway (GO:0007214)2.41222808
161heart contraction (GO:0060047)2.39671789
162heart process (GO:0003015)2.39671789
163response to redox state (GO:0051775)2.39421228
164actin filament-based movement (GO:0030048)2.39382741
165cardiac muscle cell action potential (GO:0086001)2.38551898
166membrane assembly (GO:0071709)2.38038321
167positive regulation of heart contraction (GO:0045823)2.36251851
168cytoskeletal anchoring at plasma membrane (GO:0007016)2.36001038
169peripheral nervous system axon ensheathment (GO:0032292)2.34980335
170myelination in peripheral nervous system (GO:0022011)2.34980335
171peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.34720006
172regulation of voltage-gated calcium channel activity (GO:1901385)2.32716032
173negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.32609961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.40799998
2GBX2_23144817_ChIP-Seq_PC3_Human3.40305364
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.74822381
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.72003039
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.68155390
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45842953
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27368542
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.14979434
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10721460
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09845655
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.05118878
12DROSHA_22980978_ChIP-Seq_HELA_Human2.00958574
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00919653
14REST_21632747_ChIP-Seq_MESCs_Mouse1.96368827
15JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95810757
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94982602
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88640337
18TP53_16413492_ChIP-PET_HCT116_Human1.88005285
19TAF15_26573619_Chip-Seq_HEK293_Human1.82441126
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78726495
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78459514
22* EZH2_27294783_Chip-Seq_ESCs_Mouse1.78270634
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.77955647
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77646950
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77646950
26* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76095042
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74572649
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.73300662
29SMAD4_21799915_ChIP-Seq_A2780_Human1.72463874
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.71784079
31* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70155309
32* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69124627
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.66640618
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66398803
35TP53_18474530_ChIP-ChIP_U2OS_Human1.65580750
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.65407697
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65285064
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64966085
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64944869
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64944869
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59270568
42VDR_22108803_ChIP-Seq_LS180_Human1.58586658
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58389459
44* CJUN_26792858_Chip-Seq_BT549_Human1.57750556
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55351995
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54721971
47CTNNB1_20460455_ChIP-Seq_HCT116_Human1.51442504
48EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48033406
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46742234
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45503636
51* BRD4_25478319_ChIP-Seq_HGPS_Human1.45490393
52IGF1R_20145208_ChIP-Seq_DFB_Human1.43235570
53CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42602617
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42425786
55* STAT3_23295773_ChIP-Seq_U87_Human1.42115057
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41676941
57ZNF274_21170338_ChIP-Seq_K562_Hela1.38555496
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36464241
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36464241
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36177698
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36092973
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36032502
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35539615
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.35514752
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.34606016
66* TCF4_23295773_ChIP-Seq_U87_Human1.34418106
67* RNF2_27304074_Chip-Seq_NSC_Mouse1.33787983
68* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33559105
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33507102
70P300_19829295_ChIP-Seq_ESCs_Human1.33061528
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32775118
72* TBX20_22080862_ChIP-Seq_HEART_Mouse1.32524001
73* TBX20_22328084_ChIP-Seq_HEART_Mouse1.32524001
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.29708222
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29558321
76BCAT_22108803_ChIP-Seq_LS180_Human1.28171291
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.27448432
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26859896
79* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.26554897
80MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.23629449
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23284748
82RARB_27405468_Chip-Seq_BRAIN_Mouse1.20917256
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.20322113
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19732208
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.19520341
86* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19203676
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18433334
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18324209
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18191875
90AHR_22903824_ChIP-Seq_MCF-7_Human1.17805301
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.17698281
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17254558
93KDM2B_26808549_Chip-Seq_REH_Human1.15260915
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13346908
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12772297
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.12665707
97ER_23166858_ChIP-Seq_MCF-7_Human1.12231025
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.12200304
99* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11196656
100AR_21572438_ChIP-Seq_LNCaP_Human1.10855588
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10050040
102AR_25329375_ChIP-Seq_VCAP_Human1.09251138
103* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08810053
104SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08569104
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07246681
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06961913
107KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06660401
108ISL1_27105846_Chip-Seq_CPCs_Mouse1.06612520
109* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06489204
110SOX9_26525672_Chip-Seq_HEART_Mouse1.05743019
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.04764333
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02574633
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02220920
114FLI1_27457419_Chip-Seq_LIVER_Mouse1.02160423
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.02085407
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01658818
117P53_22387025_ChIP-Seq_ESCs_Mouse1.01537948
118* SMAD4_21741376_ChIP-Seq_HESCs_Human1.01268521
119PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01119766
120RING1B_27294783_Chip-Seq_ESCs_Mouse1.00753109
121TP53_23651856_ChIP-Seq_MEFs_Mouse1.00546706
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00294666
123TAL1_26923725_Chip-Seq_HPCs_Mouse0.99912595
124RUNX2_22187159_ChIP-Seq_PCA_Human0.99870969
125AR_19668381_ChIP-Seq_PC3_Human0.99795806
126TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99768135
127SMAD4_21741376_ChIP-Seq_EPCs_Human0.98579892
128SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98344303
129CMYC_18555785_Chip-Seq_ESCs_Mouse0.98049951
130IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97072832
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96400629
132CBP_20019798_ChIP-Seq_JUKART_Human0.96400629
133NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96136383
134SMAD3_21741376_ChIP-Seq_ESCs_Human0.95517828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001984_abnormal_olfaction4.33238895
2MP0008438_abnormal_cutaneous_collagen4.13343492
3MP0005410_abnormal_fertilization3.82124292
4MP0002837_dystrophic_cardiac_calcinosis2.79697213
5MP0001958_emphysema2.77876345
6MP0009046_muscle_twitch2.74188018
7MP0005503_abnormal_tendon_morphology2.69254328
8MP0002735_abnormal_chemical_nociception2.58386897
9MP0004270_analgesia2.45791525
10MP0002734_abnormal_mechanical_nocicepti2.40369736
11MP0003279_aneurysm2.38118531
12MP0004215_abnormal_myocardial_fiber2.34902402
13MP0004510_myositis2.25927718
14MP0010368_abnormal_lymphatic_system2.23102723
15MP0003705_abnormal_hypodermis_morpholog2.21915235
16MP0002272_abnormal_nervous_system2.20038878
17MP0003635_abnormal_synaptic_transmissio2.15931247
18MP0003950_abnormal_plasma_membrane2.14093662
19MP0002184_abnormal_innervation2.12923802
20MP0001485_abnormal_pinna_reflex2.09528068
21MP0001968_abnormal_touch/_nociception2.09003989
22MP0004859_abnormal_synaptic_plasticity2.08600799
23MP0005275_abnormal_skin_tensile2.07735384
24MP0005645_abnormal_hypothalamus_physiol2.06869779
25MP0005551_abnormal_eye_electrophysiolog2.06001809
26MP0003880_abnormal_central_pattern2.03540358
27MP0009384_cardiac_valve_regurgitation2.02450115
28MP0004742_abnormal_vestibular_system2.01404795
29MP0004272_abnormal_basement_membrane1.94313247
30MP0001486_abnormal_startle_reflex1.93904808
31MP0010386_abnormal_urinary_bladder1.92870240
32MP0004885_abnormal_endolymph1.91930087
33MP0003646_muscle_fatigue1.88322227
34MP0000778_abnormal_nervous_system1.85982904
35MP0009780_abnormal_chondrocyte_physiolo1.85040577
36MP0000569_abnormal_digit_pigmentation1.84483897
37MP0009745_abnormal_behavioral_response1.84413715
38MP0004084_abnormal_cardiac_muscle1.83697923
39MP0000751_myopathy1.83144481
40MP0002063_abnormal_learning/memory/cond1.81698965
41MP0002067_abnormal_sensory_capabilities1.80960833
42MP0004036_abnormal_muscle_relaxation1.79982415
43MP0002572_abnormal_emotion/affect_behav1.74648118
44MP0006072_abnormal_retinal_apoptosis1.74641599
45MP0003698_abnormal_male_reproductive1.71970933
46MP0006138_congestive_heart_failure1.71525457
47MP0005423_abnormal_somatic_nervous1.67604198
48MP0002736_abnormal_nociception_after1.64479742
49MP0005394_taste/olfaction_phenotype1.63563764
50MP0005499_abnormal_olfactory_system1.63563764
51MP0002064_seizures1.61029001
52MP0008569_lethality_at_weaning1.60227575
53MP0001986_abnormal_taste_sensitivity1.57727459
54MP0006276_abnormal_autonomic_nervous1.56251484
55MP0001970_abnormal_pain_threshold1.52737655
56MP0008789_abnormal_olfactory_epithelium1.50255904
57MP0004145_abnormal_muscle_electrophysio1.50053935
58MP0002653_abnormal_ependyma_morphology1.49960577
59MP0000749_muscle_degeneration1.45740342
60MP0000920_abnormal_myelination1.42078715
61MP0005670_abnormal_white_adipose1.41249941
62MP0004858_abnormal_nervous_system1.38404355
63MP0002909_abnormal_adrenal_gland1.37965251
64MP0002557_abnormal_social/conspecific_i1.37709674
65MP0001502_abnormal_circadian_rhythm1.36337908
66MP0002269_muscular_atrophy1.36301025
67MP0002882_abnormal_neuron_morphology1.35655117
68MP0003566_abnormal_cell_adhesion1.34535921
69MP0004085_abnormal_heartbeat1.34206433
70MP0003137_abnormal_impulse_conducting1.33905548
71MP0002822_catalepsy1.31992145
72MP0005385_cardiovascular_system_phenoty1.30951386
73MP0001544_abnormal_cardiovascular_syste1.30951386
74MP0003091_abnormal_cell_migration1.30005944
75MP0010630_abnormal_cardiac_muscle1.26103548
76MP0005646_abnormal_pituitary_gland1.24777804
77MP0000747_muscle_weakness1.24387468
78MP0000955_abnormal_spinal_cord1.23638078
79MP0008877_abnormal_DNA_methylation1.23582441
80MP0002733_abnormal_thermal_nociception1.23424541
81MP0002752_abnormal_somatic_nervous1.22501350
82MP0005386_behavior/neurological_phenoty1.22070624
83MP0004924_abnormal_behavior1.22070624
84MP0000013_abnormal_adipose_tissue1.20913590
85MP0005253_abnormal_eye_physiology1.20353838
86MP0000759_abnormal_skeletal_muscle1.20180414
87MP0004130_abnormal_muscle_cell1.19740162
88MP0005623_abnormal_meninges_morphology1.19393924
89MP0001440_abnormal_grooming_behavior1.19013781
90MP0002229_neurodegeneration1.17902111
91MP0004484_altered_response_of1.17898181
92MP0001929_abnormal_gametogenesis1.17456819
93MP0001188_hyperpigmentation1.16935799
94MP0002638_abnormal_pupillary_reflex1.16429852
95MP0004811_abnormal_neuron_physiology1.13650209
96MP0002295_abnormal_pulmonary_circulatio1.13268586
97MP0000534_abnormal_ureter_morphology1.13107068
98MP0002972_abnormal_cardiac_muscle1.12729545
99MP0003045_fibrosis1.12376762
100MP0002163_abnormal_gland_morphology1.11298239
101MP0005165_increased_susceptibility_to1.10731830
102MP0000767_abnormal_smooth_muscle1.09811120
103MP0008775_abnormal_heart_ventricle1.09712457
104MP0005620_abnormal_muscle_contractility1.09030812
105MP0005595_abnormal_vascular_smooth1.08105637
106MP0005023_abnormal_wound_healing1.04481488
107MP0002108_abnormal_muscle_morphology1.03960176
108MP0002127_abnormal_cardiovascular_syste1.01440996
109MP0001270_distended_abdomen1.00955946
110MP0002066_abnormal_motor_capabilities/c1.00744934
111MP0005257_abnormal_intraocular_pressure0.99858400
112MP0001879_abnormal_lymphatic_vessel0.99853375
113MP0003828_pulmonary_edema0.98699045
114MP0004043_abnormal_pH_regulation0.97850866
115MP0000750_abnormal_muscle_regeneration0.97407461
116MP0001299_abnormal_eye_distance/0.96717635
117MP0003329_amyloid_beta_deposits0.96207532
118MP0005369_muscle_phenotype0.96168466
119MP0001963_abnormal_hearing_physiology0.96006171
120MP0001348_abnormal_lacrimal_gland0.95263816
121MP0003879_abnormal_hair_cell0.94256413
122MP0003690_abnormal_glial_cell0.93567405
123MP0003634_abnormal_glial_cell0.89607313
124MP0005508_abnormal_skeleton_morphology0.89240619
125MP0001529_abnormal_vocalization0.88838676
126MP0001501_abnormal_sleep_pattern0.88773704
127MP0003283_abnormal_digestive_organ0.88472097
128MP0009250_abnormal_appendicular_skeleto0.87326889
129MP0002160_abnormal_reproductive_system0.86410265
130MP0002152_abnormal_brain_morphology0.86246735
131MP0000003_abnormal_adipose_tissue0.85796337
132MP0004142_abnormal_muscle_tone0.85426625
133MP0003183_abnormal_peptide_metabolism0.84798456
134MP0005171_absent_coat_pigmentation0.84362933
135MP0002896_abnormal_bone_mineralization0.82743806
136MP0002210_abnormal_sex_determination0.82215987
137MP0004087_abnormal_muscle_fiber0.81310847
138MP0003633_abnormal_nervous_system0.80945522
139MP0002234_abnormal_pharynx_morphology0.80038998
140MP0005330_cardiomyopathy0.78954140
141MP0005195_abnormal_posterior_eye0.78222287
142MP0005379_endocrine/exocrine_gland_phen0.78042783
143MP0002161_abnormal_fertility/fecundity0.76070072
144MP0001542_abnormal_bone_strength0.75810705
145MP0002128_abnormal_blood_circulation0.75161040
146MP0004233_abnormal_muscle_weight0.73546185
147MP0000733_abnormal_muscle_development0.72548124
148MP0002090_abnormal_vision0.72166016
149MP0005409_darkened_coat_color0.71616534
150MP0002106_abnormal_muscle_physiology0.71505597
151MP0005187_abnormal_penis_morphology0.71076750

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.88673143
2Absent/shortened dynein arms (HP:0200106)5.37918699
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.37918699
4Abnormal respiratory motile cilium physiology (HP:0012261)4.99784562
5Premature rupture of membranes (HP:0001788)4.52964801
6Abnormal respiratory epithelium morphology (HP:0012253)4.38360291
7Abnormal respiratory motile cilium morphology (HP:0005938)4.38360291
8Protrusio acetabuli (HP:0003179)4.37602795
9Abnormal ciliary motility (HP:0012262)4.32717750
10Rhinitis (HP:0012384)3.92535801
11Aortic aneurysm (HP:0004942)3.82548715
12Lipoatrophy (HP:0100578)3.74579202
13Chronic bronchitis (HP:0004469)3.67881227
14Aortic dissection (HP:0002647)3.64712089
15Febrile seizures (HP:0002373)3.61043413
16Congenital stationary night blindness (HP:0007642)3.55886365
17Central scotoma (HP:0000603)3.38637309
18Syncope (HP:0001279)3.37589587
19Prolonged QT interval (HP:0001657)3.26791487
20Atrial fibrillation (HP:0005110)3.26624168
21Sudden death (HP:0001699)3.23329071
22Focal motor seizures (HP:0011153)3.18085332
23Type 1 muscle fiber predominance (HP:0003803)3.14805431
24Right ventricular cardiomyopathy (HP:0011663)3.12955389
25Progressive cerebellar ataxia (HP:0002073)3.07820370
26Primary atrial arrhythmia (HP:0001692)3.06972698
27Vascular tortuosity (HP:0004948)3.05725473
28Broad metatarsal (HP:0001783)3.03908140
29Male infertility (HP:0003251)3.01640318
30Atrophic scars (HP:0001075)2.98589936
31Pheochromocytoma (HP:0002666)2.96438420
32Ventricular fibrillation (HP:0001663)2.89988147
33Arterial tortuosity (HP:0005116)2.86822085
34Abnormality of macular pigmentation (HP:0008002)2.85729604
35Supraventricular tachycardia (HP:0004755)2.85637841
36Atrioventricular block (HP:0001678)2.85252316
37Shallow orbits (HP:0000586)2.81354587
38Medial flaring of the eyebrow (HP:0010747)2.81119329
39Epileptic encephalopathy (HP:0200134)2.79681166
40Scanning speech (HP:0002168)2.78403996
41Muscle fiber splitting (HP:0003555)2.77521954
42Supraventricular arrhythmia (HP:0005115)2.74508558
43Dilated cardiomyopathy (HP:0001644)2.70450434
44Focal seizures (HP:0007359)2.70313791
45Nephronophthisis (HP:0000090)2.69395966
46Decreased central vision (HP:0007663)2.69190130
47Atonic seizures (HP:0010819)2.69000866
48Gaze-evoked nystagmus (HP:0000640)2.65524220
49Action tremor (HP:0002345)2.64156986
50Asymmetric septal hypertrophy (HP:0001670)2.63886207
51Neonatal short-limb short stature (HP:0008921)2.61692504
52Hypoplasia of the iris (HP:0007676)2.60410987
53Infertility (HP:0000789)2.60238188
54Bundle branch block (HP:0011710)2.60093546
55Neuroendocrine neoplasm (HP:0100634)2.59520951
56Wormian bones (HP:0002645)2.57752648
57Retinal dysplasia (HP:0007973)2.57431565
58Ankle contracture (HP:0006466)2.52445592
59Severe visual impairment (HP:0001141)2.50853763
60Gait imbalance (HP:0002141)2.50226919
61Palpitations (HP:0001962)2.48463476
62Soft skin (HP:0000977)2.46462804
63Abnormal EKG (HP:0003115)2.45568598
64Distal lower limb muscle weakness (HP:0009053)2.44053451
65Myokymia (HP:0002411)2.43342873
66Dysmetric saccades (HP:0000641)2.41111450
67Increased variability in muscle fiber diameter (HP:0003557)2.39795538
68Bladder diverticulum (HP:0000015)2.37479191
69Congenital primary aphakia (HP:0007707)2.33530836
70Calf muscle hypertrophy (HP:0008981)2.33319335
71EMG: myopathic abnormalities (HP:0003458)2.30098211
72Keratoconus (HP:0000563)2.29733757
73Increased corneal curvature (HP:0100692)2.29733757
74Nephrogenic diabetes insipidus (HP:0009806)2.28082250
75Absence seizures (HP:0002121)2.27726873
76Overgrowth (HP:0001548)2.27417752
77Scapular winging (HP:0003691)2.26801346
78Bronchiectasis (HP:0002110)2.24409655
79Spinal rigidity (HP:0003306)2.24224974
80Aneurysm (HP:0002617)2.23722054
81Abnormality of the renal medulla (HP:0100957)2.22689159
82Molar tooth sign on MRI (HP:0002419)2.22057178
83Abnormality of midbrain morphology (HP:0002418)2.22057178
84Mitral regurgitation (HP:0001653)2.21092695
85Subaortic stenosis (HP:0001682)2.20286461
86Abnormality of the left ventricular outflow tract (HP:0011103)2.20286461
87Muscle hypertrophy of the lower extremities (HP:0008968)2.19993578
88Left ventricular hypertrophy (HP:0001712)2.18539959
89Lower limb amyotrophy (HP:0007210)2.17178572
90Exercise-induced myalgia (HP:0003738)2.17142446
91Abnormal rod and cone electroretinograms (HP:0008323)2.15743496
92Mildly elevated creatine phosphokinase (HP:0008180)2.15156853
93Mitral stenosis (HP:0001718)2.13894078
94Wide anterior fontanel (HP:0000260)2.12430104
95Truncal ataxia (HP:0002078)2.10471412
96Coronal craniosynostosis (HP:0004440)2.10189333
97Osteolytic defects of the hand bones (HP:0009699)2.08555619
98Osteolytic defects of the phalanges of the hand (HP:0009771)2.08555619
99Fragile skin (HP:0001030)2.08150078
100Bowel diverticulosis (HP:0005222)2.05929959
101Follicular hyperkeratosis (HP:0007502)2.05067225
102Abnormality of the foot musculature (HP:0001436)2.03960425
103Abnormality of dentin (HP:0010299)2.01972947
104Abnormality of the lower motor neuron (HP:0002366)2.01041570
105Ulnar bowing (HP:0003031)2.01030329
106Insidious onset (HP:0003587)2.01015676
107Termporal pattern (HP:0011008)2.01015676
108Genital tract atresia (HP:0001827)2.00736162
109Anosmia (HP:0000458)1.99046978
110Generalized tonic-clonic seizures (HP:0002069)1.98014958
111Vaginal atresia (HP:0000148)1.96662434
112Aortic regurgitation (HP:0001659)1.96562090
113Bradycardia (HP:0001662)1.94971958
114Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.93777040
115Abnormality of the right ventricle (HP:0001707)1.92349406
116Scotoma (HP:0000575)1.92134941
117Neck muscle weakness (HP:0000467)1.91811338
118Increased connective tissue (HP:0009025)1.91774417
119Dialeptic seizures (HP:0011146)1.91149486
120Foot dorsiflexor weakness (HP:0009027)1.90780550
121Abnormal drinking behavior (HP:0030082)1.90410192
122Polydipsia (HP:0001959)1.90410192
123Tubulointerstitial nephritis (HP:0001970)1.89409483
124Heart block (HP:0012722)1.89102224
125Abnormality of skeletal muscle fiber size (HP:0012084)1.88557424
126Limited hip movement (HP:0008800)1.88513858
127Visual hallucinations (HP:0002367)1.88199928
128Genu recurvatum (HP:0002816)1.87970719
129EMG: neuropathic changes (HP:0003445)1.87376446
130Spondylolisthesis (HP:0003302)1.87276299
131Aplasia/Hypoplasia of the lens (HP:0008063)1.85666956
132Distal lower limb amyotrophy (HP:0008944)1.83649387
133Ventricular arrhythmia (HP:0004308)1.83227268
134Hypoventilation (HP:0002791)1.82419735
135Abnormality of cochlea (HP:0000375)1.81694308
136Poor coordination (HP:0002370)1.81576642
137Ventricular tachycardia (HP:0004756)1.81292782
138Bony spicule pigmentary retinopathy (HP:0007737)1.80139719
139Abnormality of the calf musculature (HP:0001430)1.78492619
140Dysmetria (HP:0001310)1.78436511
141Agitation (HP:0000713)1.77578509
142Lower limb muscle weakness (HP:0007340)1.77424246
143Hyporeflexia of lower limbs (HP:0002600)1.76204750
144Mitral valve prolapse (HP:0001634)1.75975256
145Vertebral arch anomaly (HP:0008438)1.75071592
146Hypothermia (HP:0002045)1.74457227
147Dilatation of the ascending aorta (HP:0005111)1.74405321
148Aplasia/Hypoplasia of the fovea (HP:0008060)1.74066342
149Hypoplasia of the fovea (HP:0007750)1.74066342
150Ulnar claw (HP:0001178)1.73752395
151Neurofibrillary tangles (HP:0002185)1.73121477
152Mild short stature (HP:0003502)1.72762336
153Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72505767
154Decreased circulating renin level (HP:0003351)1.72205182
155Cerebral aneurysm (HP:0004944)1.71892498
156Dyschromatopsia (HP:0007641)1.71385528
157Optic nerve hypoplasia (HP:0000609)1.71099020
158Hyperextensible skin (HP:0000974)1.71091499
159Abnormal atrioventricular conduction (HP:0005150)1.70983213
160Steppage gait (HP:0003376)1.70606763
161Peritonitis (HP:0002586)1.68671116
162Hammertoe (HP:0001765)1.68646833
163Specific learning disability (HP:0001328)1.68010810
164Morphological abnormality of the inner ear (HP:0011390)1.66302152
165Infantile muscular hypotonia (HP:0008947)1.65804260
166Difficulty climbing stairs (HP:0003551)1.65695248
167Abnormality of the corticospinal tract (HP:0002492)1.65533926
168Limb dystonia (HP:0002451)1.65467354
169Distal upper limb amyotrophy (HP:0007149)1.65410093
170Aplasia/Hypoplasia of the brainstem (HP:0007362)1.64908025
171Hypoplasia of the brainstem (HP:0002365)1.64908025
172Hyperventilation (HP:0002883)1.63955882
173Abnormality of the renal cortex (HP:0011035)1.63651115
174Abnormality of the fovea (HP:0000493)1.62476945
175Pancreatic fibrosis (HP:0100732)1.61002422

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK26.34995927
2MYLK5.18408153
3TTN3.80616930
4PDK33.69959716
5PDK43.69959716
6DMPK3.14149124
7PHKG23.08148543
8PHKG13.08148543
9NEK92.96025210
10CASK2.70998718
11LIMK12.37122974
12PDK22.26488566
13NTRK32.26131314
14MARK12.14033810
15STK392.05370887
16PDGFRA2.04500315
17DDR21.90869971
18LATS21.83906793
19PINK11.77084598
20PAK21.68773379
21MAP3K41.66169597
22MAP2K71.64305492
23STK38L1.51673567
24SGK2231.51392410
25SGK4941.51392410
26WNK41.49722955
27PTK21.49621350
28MAPK151.48091819
29CAMK2D1.47293937
30STK381.46595772
31LATS11.46549316
32PRKD31.46414885
33WNK11.44813667
34SGK21.44612402
35MET1.36772426
36MINK11.32690631
37MUSK1.23113628
38PRKG21.21422346
39NTRK21.20960163
40CAMKK21.19861019
41TRPM71.18279236
42PRPF4B1.17496734
43MAPK131.12941921
44ADRBK21.10196225
45IRAK11.08986193
46PIK3CA1.08758946
47INSRR1.08758276
48RIPK11.00565563
49PRKAA10.97765975
50PKN10.96451739
51STK240.96035123
52PDGFRB0.93881026
53TNIK0.93871628
54NTRK10.93413069
55BMPR1B0.92024109
56PLK20.91974624
57ICK0.91933591
58AKT30.91671874
59SGK30.89463349
60PAK30.88274914
61CAMK2A0.87784720
62PRKD20.87113912
63PNCK0.86983516
64PTK2B0.85714153
65CDC42BPA0.85265229
66UHMK10.85021354
67CDK30.84866763
68PAK60.84586267
69PRKCE0.82408620
70DAPK30.82305294
71CAMK1G0.80166613
72MAP3K20.79820266
73KSR20.79190986
74HIPK20.78319602
75OBSCN0.77101051
76IRAK20.75077671
77GRK50.71040456
78EPHA30.70542288
79CDK50.69927052
80PRKCG0.69913958
81ERBB40.69777456
82CAMK2B0.69522648
83CAMKK10.69386960
84CAMK40.69385680
85PRKCH0.69358376
86RET0.68938249
87CAMK10.66953654
88MARK20.66017710
89MAPK70.65064808
90CAMK2G0.63831192
91DAPK20.63667996
92DYRK1B0.63560742
93MOS0.62492310
94MAPK120.62390454
95FER0.62062909
96PRKG10.61994429
97ROCK10.60331208
98EPHA40.60328659
99MAP2K10.59186476
100MAPKAPK50.55831442
101DYRK1A0.55356988
102FRK0.54644349
103MAP3K60.53891614
104KSR10.53479939
105PRKACA0.53391313
106ERBB30.52834597
107PIK3CG0.52192851
108MAPK100.52120328
109MAP3K70.51391728
110MTOR0.50388208
111RPS6KA20.49612805
112MAP3K90.49413288
113EPHB20.48348585
114RPS6KA30.46834535
115SIK20.45928650
116CDK150.45198048
117PRKD10.43876826
118TESK10.42507480
119MAP2K40.42029481
120ROCK20.41784115
121CDK180.41762193
122SGK10.41620967
123STK110.41322835
124BCR0.39719629
125PRKACG0.39029694
126GRK70.38610709
127TGFBR20.38473306
128MAPK40.37709283
129OXSR10.37251215
130CDK11A0.36638516
131PDK10.36306176
132TIE10.35585058
133ADRBK10.35439512
134NEK60.34423902
135TYRO30.33836655
136PRKAA20.33783132
137BMPR20.33315280
138ERBB20.33243591
139GSK3A0.31902713

Predicted pathways (KEGG)

RankGene SetZ-score
1* Olfactory transduction_Homo sapiens_hsa047403.46808366
2Synaptic vesicle cycle_Homo sapiens_hsa047212.66643949
3Nicotine addiction_Homo sapiens_hsa050332.64548753
4* Taste transduction_Homo sapiens_hsa047422.45188636
5Insulin secretion_Homo sapiens_hsa049112.37629275
6GABAergic synapse_Homo sapiens_hsa047272.34159128
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33763903
8Circadian entrainment_Homo sapiens_hsa047132.32974752
9* Morphine addiction_Homo sapiens_hsa050322.32900826
10Cardiac muscle contraction_Homo sapiens_hsa042602.24607751
11Glutamatergic synapse_Homo sapiens_hsa047242.16142192
12ECM-receptor interaction_Homo sapiens_hsa045122.04790976
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.86143371
14Cholinergic synapse_Homo sapiens_hsa047251.83549480
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.83332308
16Focal adhesion_Homo sapiens_hsa045101.82567766
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74959865
18Dopaminergic synapse_Homo sapiens_hsa047281.69745940
19Amphetamine addiction_Homo sapiens_hsa050311.69168985
20Dilated cardiomyopathy_Homo sapiens_hsa054141.68872732
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.61261516
22Salivary secretion_Homo sapiens_hsa049701.58402533
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56490128
24Gastric acid secretion_Homo sapiens_hsa049711.56413576
25Serotonergic synapse_Homo sapiens_hsa047261.45090905
26Long-term potentiation_Homo sapiens_hsa047201.43949644
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.42179090
28* Calcium signaling pathway_Homo sapiens_hsa040201.41904297
29cAMP signaling pathway_Homo sapiens_hsa040241.39516545
30* Renin secretion_Homo sapiens_hsa049241.36620012
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36025183
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34726624
33Type II diabetes mellitus_Homo sapiens_hsa049301.34705144
34Collecting duct acid secretion_Homo sapiens_hsa049661.33402369
35Phototransduction_Homo sapiens_hsa047441.33349401
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27492438
37Oxytocin signaling pathway_Homo sapiens_hsa049211.25554129
38Adherens junction_Homo sapiens_hsa045201.25105154
39Dorso-ventral axis formation_Homo sapiens_hsa043201.20500980
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20231364
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20061676
42Vibrio cholerae infection_Homo sapiens_hsa051101.19299495
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17267281
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16065994
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15861703
46Glucagon signaling pathway_Homo sapiens_hsa049221.11451039
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06490248
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04642635
49Cocaine addiction_Homo sapiens_hsa050301.03555900
50Pancreatic secretion_Homo sapiens_hsa049721.03473484
51Proteoglycans in cancer_Homo sapiens_hsa052051.01852542
52Tight junction_Homo sapiens_hsa045300.99635601
53Hippo signaling pathway_Homo sapiens_hsa043900.99015471
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97182888
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97026614
56Amoebiasis_Homo sapiens_hsa051460.96888585
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93819184
58Axon guidance_Homo sapiens_hsa043600.93085007
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.92077811
60Protein digestion and absorption_Homo sapiens_hsa049740.91157216
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90533057
62Pyruvate metabolism_Homo sapiens_hsa006200.89635426
63Oxidative phosphorylation_Homo sapiens_hsa001900.87121502
64Huntingtons disease_Homo sapiens_hsa050160.86032647
65Gap junction_Homo sapiens_hsa045400.85382795
66Alzheimers disease_Homo sapiens_hsa050100.85379880
67Prion diseases_Homo sapiens_hsa050200.84320417
68Estrogen signaling pathway_Homo sapiens_hsa049150.82821439
69Propanoate metabolism_Homo sapiens_hsa006400.81303728
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79611809
71Long-term depression_Homo sapiens_hsa047300.78593722
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77288213
73ABC transporters_Homo sapiens_hsa020100.76806964
74Parkinsons disease_Homo sapiens_hsa050120.75088400
75GnRH signaling pathway_Homo sapiens_hsa049120.74077723
76Thyroid hormone synthesis_Homo sapiens_hsa049180.73593030
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71353058
78Circadian rhythm_Homo sapiens_hsa047100.69550103
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68898154
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67546765
81Inositol phosphate metabolism_Homo sapiens_hsa005620.67172518
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66681648
83Mineral absorption_Homo sapiens_hsa049780.66239273
84Ovarian steroidogenesis_Homo sapiens_hsa049130.65129896
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64600612
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.63145593
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61098011
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60271337
89Melanogenesis_Homo sapiens_hsa049160.59958155
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.59932044
91Oocyte meiosis_Homo sapiens_hsa041140.58721859
92MAPK signaling pathway_Homo sapiens_hsa040100.56833101
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.56368284
94Platelet activation_Homo sapiens_hsa046110.55545716
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.53100034
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50862869
97Insulin signaling pathway_Homo sapiens_hsa049100.50118834
98Renal cell carcinoma_Homo sapiens_hsa052110.49328967
99Alcoholism_Homo sapiens_hsa050340.48602079
100Wnt signaling pathway_Homo sapiens_hsa043100.48473572
101ErbB signaling pathway_Homo sapiens_hsa040120.47264499
102Melanoma_Homo sapiens_hsa052180.46647528
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46632879
104AMPK signaling pathway_Homo sapiens_hsa041520.46586236
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46411093
106Pathways in cancer_Homo sapiens_hsa052000.45524317
107Bile secretion_Homo sapiens_hsa049760.45115706
108Hedgehog signaling pathway_Homo sapiens_hsa043400.44667279
109Arginine and proline metabolism_Homo sapiens_hsa003300.43728693
110Small cell lung cancer_Homo sapiens_hsa052220.43494196
111MicroRNAs in cancer_Homo sapiens_hsa052060.43279271
112Ras signaling pathway_Homo sapiens_hsa040140.43090756
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41774787
114Choline metabolism in cancer_Homo sapiens_hsa052310.41212775
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40847970
116Sphingolipid metabolism_Homo sapiens_hsa006000.39762694
117TGF-beta signaling pathway_Homo sapiens_hsa043500.38059992
118Endometrial cancer_Homo sapiens_hsa052130.38049312
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37353622
120Glioma_Homo sapiens_hsa052140.36158927
121Rap1 signaling pathway_Homo sapiens_hsa040150.35273368
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.34617821
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.33468207
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32399469
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31964083
126Insulin resistance_Homo sapiens_hsa049310.31594967
127Colorectal cancer_Homo sapiens_hsa052100.30574506
128Endocytosis_Homo sapiens_hsa041440.30016195

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