PDE3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.55101069
2cardiac myofibril assembly (GO:0055003)5.24289749
3cellular response to epinephrine stimulus (GO:0071872)5.14424435
4response to epinephrine (GO:0071871)5.14151919
5coronary vasculature morphogenesis (GO:0060977)5.04691454
6midgut development (GO:0007494)4.98247939
7carnitine shuttle (GO:0006853)4.74207984
8regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.50340446
9adrenergic receptor signaling pathway (GO:0071875)4.50031109
10detection of calcium ion (GO:0005513)4.37953055
11myofibril assembly (GO:0030239)4.25399272
12heart trabecula formation (GO:0060347)4.08152889
13fatty acid transmembrane transport (GO:1902001)4.04972801
14atrial septum morphogenesis (GO:0060413)4.03108865
15negative regulation of striated muscle cell apoptotic process (GO:0010664)4.01894958
16regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.98895494
17sarcomere organization (GO:0045214)3.98103069
18cardiac muscle hypertrophy (GO:0003300)3.96475986
19cardiac muscle cell development (GO:0055013)3.96439027
20regulation of actin filament-based movement (GO:1903115)3.92156889
21regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.90625928
22neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.83663565
23positive regulation of heart rate (GO:0010460)3.80888203
24homocysteine metabolic process (GO:0050667)3.79453818
25cardiac cell development (GO:0055006)3.79016316
26carnitine transmembrane transport (GO:1902603)3.75875596
27striated muscle hypertrophy (GO:0014897)3.73890568
28negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.71042864
29cardiac right ventricle morphogenesis (GO:0003215)3.68869162
30response to caffeine (GO:0031000)3.63903005
31regulation of cardiac muscle cell contraction (GO:0086004)3.62890991
32heart valve formation (GO:0003188)3.58949900
33* cAMP catabolic process (GO:0006198)3.55542229
34cardiac muscle cell action potential involved in contraction (GO:0086002)3.51038963
35amino-acid betaine transport (GO:0015838)3.45810846
36carnitine transport (GO:0015879)3.45810846
37positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.44394265
38striated muscle contraction (GO:0006941)3.43603906
39glomerular basement membrane development (GO:0032836)3.41676939
40ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.39475007
41positive regulation of heart contraction (GO:0045823)3.39344032
42muscle hypertrophy (GO:0014896)3.38725986
43response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.36954886
44regulation of relaxation of muscle (GO:1901077)3.35565150
45negative regulation of smooth muscle cell differentiation (GO:0051151)3.34713375
46negative regulation of potassium ion transmembrane transport (GO:1901380)3.34502665
47positive regulation of cardiac muscle tissue growth (GO:0055023)3.33645687
48ventricular cardiac muscle cell development (GO:0055015)3.31601586
49regulation of cardiac muscle cell apoptotic process (GO:0010665)3.30206188
50cardiac muscle tissue morphogenesis (GO:0055008)3.29918638
51trabecula formation (GO:0060343)3.28392324
52regulation of cardioblast differentiation (GO:0051890)3.28198475
53* cyclic nucleotide catabolic process (GO:0009214)3.27707544
54cardiac muscle hypertrophy in response to stress (GO:0014898)3.25255439
55muscle hypertrophy in response to stress (GO:0003299)3.25255439
56cardiac muscle adaptation (GO:0014887)3.25255439
57sarcoplasmic reticulum calcium ion transport (GO:0070296)3.23317411
58adult heart development (GO:0007512)3.22024904
59positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.21952900
60sequestering of extracellular ligand from receptor (GO:0035581)3.20820234
61glomerulus development (GO:0032835)3.19182024
62desmosome organization (GO:0002934)3.18174620
63cardiac muscle contraction (GO:0060048)3.15870897
64ventricular cardiac muscle cell action potential (GO:0086005)3.14774501
65positive regulation of cardiac muscle tissue development (GO:0055025)3.13470664
66negative regulation of complement activation (GO:0045916)3.13339968
67regulation of sarcomere organization (GO:0060297)3.12968490
68pericardium development (GO:0060039)3.12044273
69endocardial cushion morphogenesis (GO:0003203)3.11498603
70muscle tissue morphogenesis (GO:0060415)3.10994036
71glomerular filtration (GO:0003094)3.10588435
72cell migration involved in heart development (GO:0060973)3.10041494
73retina vasculature morphogenesis in camera-type eye (GO:0061299)3.09617922
74actomyosin structure organization (GO:0031032)3.09593025
75outflow tract septum morphogenesis (GO:0003148)3.08248281
76cell proliferation involved in metanephros development (GO:0072203)3.07341292
77regulation of cardiac muscle contraction (GO:0055117)3.07061171
78positive regulation of heart growth (GO:0060421)3.05691389
79regulation of smooth muscle cell differentiation (GO:0051150)3.04966614
80response to catecholamine (GO:0071869)3.04796913
81response to monoamine (GO:0071867)3.04796913
82actin-mediated cell contraction (GO:0070252)3.04685406
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.03341907
84regulation of heart contraction (GO:0008016)3.02594233
85atrioventricular valve morphogenesis (GO:0003181)3.02447449
86cellular response to catecholamine stimulus (GO:0071870)2.98851427
87cellular response to monoamine stimulus (GO:0071868)2.98851427
88regulation of striated muscle cell apoptotic process (GO:0010662)2.98525267
89response to dexamethasone (GO:0071548)2.98520608
90vascular endothelial growth factor signaling pathway (GO:0038084)2.98082264
91regulation of striated muscle contraction (GO:0006942)2.97956166
92positive regulation of cardiac muscle cell proliferation (GO:0060045)2.97719057
93bundle of His cell to Purkinje myocyte communication (GO:0086069)2.97337073
94tonic smooth muscle contraction (GO:0014820)2.97190189
95relaxation of cardiac muscle (GO:0055119)2.94342751
96regulation of cell communication by electrical coupling (GO:0010649)2.93529292
97nuclear pore complex assembly (GO:0051292)2.91042262
98cell proliferation involved in kidney development (GO:0072111)2.90864988
99renal filtration (GO:0097205)2.88871324
100glomerular visceral epithelial cell development (GO:0072015)2.87733234
101response to inactivity (GO:0014854)2.85705991
102mesenchyme morphogenesis (GO:0072132)2.85090643
103regulation of cardiac muscle cell differentiation (GO:2000725)2.84047249
104regulation of skeletal muscle contraction (GO:0014819)2.83133420
105muscle filament sliding (GO:0030049)2.82809613
106actin-myosin filament sliding (GO:0033275)2.82809613
107regulation of calcium ion transmembrane transporter activity (GO:1901019)2.82531612
108regulation of calcium ion transmembrane transport (GO:1903169)2.82531612
109mesenchymal cell development (GO:0014031)2.81585672
110cell communication involved in cardiac conduction (GO:0086065)2.81515558
111ventricular trabecula myocardium morphogenesis (GO:0003222)2.81013449
112negative regulation of protein activation cascade (GO:2000258)2.80870913
113tricarboxylic acid cycle (GO:0006099)2.80666167
114regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.80417565
115smooth muscle tissue development (GO:0048745)2.79846459
116heart process (GO:0003015)2.79343733
117heart contraction (GO:0060047)2.79343733
118urea cycle (GO:0000050)2.78477622
119regulation of membrane repolarization (GO:0060306)2.78392055
120venous blood vessel morphogenesis (GO:0048845)2.75508965
121heart morphogenesis (GO:0003007)2.75322956
122regulation of ATP catabolic process (GO:1903289)2.74969834
123regulation of ATPase activity (GO:0043462)2.74969834
124citrulline biosynthetic process (GO:0019240)2.74418648
125notochord development (GO:0030903)2.74143098
126positive regulation of cardiac muscle cell differentiation (GO:2000727)2.73164880
127Notch signaling involved in heart development (GO:0061314)2.72735721
128regulation of cardiac muscle tissue growth (GO:0055021)2.72317037
129embryonic heart tube development (GO:0035050)2.71852265
130regulation of the force of heart contraction (GO:0002026)2.71537444
131* cGMP-mediated signaling (GO:0019934)2.70748741
132cellular response to glucagon stimulus (GO:0071377)2.67405558
133regulation of heart rate (GO:0002027)2.67393650
134membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.66517894
135gap junction assembly (GO:0016264)2.66446114
136negative regulation of heart contraction (GO:0045822)2.65957148
137metanephric mesenchyme development (GO:0072075)2.64211706
138regulation of cardiac muscle tissue development (GO:0055024)2.63394252
139heart valve morphogenesis (GO:0003179)2.62460853
140plasma membrane repair (GO:0001778)2.60648314
141regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.60171314
142regulation of vasculogenesis (GO:2001212)2.59658965
143cell communication by electrical coupling (GO:0010644)2.58064758
144regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.57848423
145cardiac muscle cell action potential (GO:0086001)2.57809746
146actin filament-based movement (GO:0030048)2.54429325
147regulation of non-canonical Wnt signaling pathway (GO:2000050)2.53666455
148positive regulation of muscle hypertrophy (GO:0014742)2.52358813

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.49866952
2EZH2_22144423_ChIP-Seq_EOC_Human3.51139489
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.45238868
4EP300_21415370_ChIP-Seq_HL-1_Mouse2.95612285
5GBX2_23144817_ChIP-Seq_PC3_Human2.66613990
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.55401431
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.54358245
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.49936915
9* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45666170
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43264805
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36472658
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.27935384
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.18862164
14* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.17669443
15ZNF263_19887448_ChIP-Seq_K562_Human2.13431390
16* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07363084
17* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07363084
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.06023208
19* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05083569
20* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02488518
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02273465
22GATA1_22025678_ChIP-Seq_K562_Human2.02116632
23* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96444037
24* EZH2_27304074_Chip-Seq_ESCs_Mouse1.94813042
25* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.94257391
26* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89114345
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.82417660
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.75629509
29* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71438941
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70516230
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.70430438
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69056671
33* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68690040
34AR_21572438_ChIP-Seq_LNCaP_Human1.68472862
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66389482
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.63911401
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62106507
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61500407
39* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59514420
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.54569935
41* BCAT_22108803_ChIP-Seq_LS180_Human1.53716060
42SMAD4_21799915_ChIP-Seq_A2780_Human1.51896639
43TP53_16413492_ChIP-PET_HCT116_Human1.51766042
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51570267
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.48019137
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.47501733
47VDR_22108803_ChIP-Seq_LS180_Human1.45399092
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44149347
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43818992
50* CJUN_26792858_Chip-Seq_BT549_Human1.43271712
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40477425
52* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40218052
53* ISL1_27105846_Chip-Seq_CPCs_Mouse1.39485444
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37687255
55* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37212492
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.34626126
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.33931513
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33764026
59* TBX20_22080862_ChIP-Seq_HEART_Mouse1.33195888
60* TBX20_22328084_ChIP-Seq_HEART_Mouse1.33195888
61DROSHA_22980978_ChIP-Seq_HELA_Human1.32504380
62AHR_22903824_ChIP-Seq_MCF-7_Human1.32355958
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30598580
64TAF15_26573619_Chip-Seq_HEK293_Human1.29556128
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29368319
66TCF4_18268006_ChIP-ChIP_LS174T_Human1.28468277
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27433740
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27357671
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.27167615
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26880053
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26880053
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26679638
73TP53_18474530_ChIP-ChIP_U2OS_Human1.26453734
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26170721
75PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.25700738
76* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25067333
77CLOCK_20551151_ChIP-Seq_293T_Human1.25048425
78SOX9_26525672_Chip-Seq_HEART_Mouse1.24797649
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23813606
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22801376
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22420360
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20448663
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20416630
84* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19948927
85MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19791047
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19436409
87* P300_19829295_ChIP-Seq_ESCs_Human1.18332400
88* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18271136
89* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.17914008
90* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17844861
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15793552
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15666090
93* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14501638
94* STAT3_23295773_ChIP-Seq_U87_Human1.13677317
95GATA2_21666600_ChIP-Seq_HMVEC_Human1.11727216
96* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11694008
97SMAD3_21741376_ChIP-Seq_HESCs_Human1.11455306
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.11169746
99* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10253555
100* FUS_26573619_Chip-Seq_HEK293_Human1.06954901
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06793516
102* EWS_26573619_Chip-Seq_HEK293_Human1.06544461
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06004027
104STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05722500
105GATA4_21415370_ChIP-Seq_HL-1_Mouse1.04846721
106E2F1_18555785_Chip-Seq_ESCs_Mouse1.04354068
107FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04034826
108SMAD4_21741376_ChIP-Seq_HESCs_Human1.03276063
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.02688075
110* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02649143
111* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02506956
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.02500467
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.02304263
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02237976
115RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01946786
116RING1B_27294783_Chip-Seq_ESCs_Mouse1.00562410
117AR_19668381_ChIP-Seq_PC3_Human1.00432426
118TBL1_22424771_ChIP-Seq_293T_Human0.98890573
119FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98638620
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98399399
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97679319
122* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96896904
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96571998
124AR_25329375_ChIP-Seq_VCAP_Human0.96455180
125RUNX2_22187159_ChIP-Seq_PCA_Human0.96392733
126* TCF4_23295773_ChIP-Seq_U87_Human0.95731809
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95265262
128ESR1_21235772_ChIP-Seq_MCF-7_Human0.94612726
129ZNF274_21170338_ChIP-Seq_K562_Hela0.94232172
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93331281
131* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92507363
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92423881
133* RING1B_27294783_Chip-Seq_NPCs_Mouse0.91408823
134* PRDM14_20953172_ChIP-Seq_ESCs_Human0.90831841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.01272217
2MP0004084_abnormal_cardiac_muscle3.73768968
3MP0000751_myopathy3.51944631
4MP0004215_abnormal_myocardial_fiber3.47215975
5MP0005503_abnormal_tendon_morphology3.23325991
6MP0009384_cardiac_valve_regurgitation3.12980044
7MP0004272_abnormal_basement_membrane2.88645614
8MP0010368_abnormal_lymphatic_system2.71637520
9MP0005330_cardiomyopathy2.70397185
10MP0008438_abnormal_cutaneous_collagen2.67148600
11MP0004036_abnormal_muscle_relaxation2.66049911
12MP0008775_abnormal_heart_ventricle2.64928777
13MP0003950_abnormal_plasma_membrane2.44412264
14MP0003279_aneurysm2.44064209
15MP0006138_congestive_heart_failure2.43843932
16MP0002972_abnormal_cardiac_muscle2.41466181
17MP0005670_abnormal_white_adipose2.32770870
18MP0002127_abnormal_cardiovascular_syste2.30157986
19MP0005620_abnormal_muscle_contractility2.18944779
20MP0004085_abnormal_heartbeat2.12080015
21MP0004484_altered_response_of2.06501822
22MP0003941_abnormal_skin_development2.04828480
23MP0000749_muscle_degeneration2.03244431
24MP0003137_abnormal_impulse_conducting2.02647481
25MP0003646_muscle_fatigue2.01492414
26MP0005385_cardiovascular_system_phenoty1.92094002
27MP0001544_abnormal_cardiovascular_syste1.92094002
28MP0001879_abnormal_lymphatic_vessel1.84439189
29MP0004087_abnormal_muscle_fiber1.73969913
30MP0002108_abnormal_muscle_morphology1.73398584
31MP0005275_abnormal_skin_tensile1.72371213
32MP0003136_yellow_coat_color1.71127829
33MP0010630_abnormal_cardiac_muscle1.69395702
34MP0002877_abnormal_melanocyte_morpholog1.69377791
35MP0003828_pulmonary_edema1.66204948
36MP0000767_abnormal_smooth_muscle1.58443753
37MP0003385_abnormal_body_wall1.55164888
38MP0001958_emphysema1.52848581
39MP0010386_abnormal_urinary_bladder1.50257597
40MP0005369_muscle_phenotype1.38899266
41MP0005623_abnormal_meninges_morphology1.38875159
42MP0000750_abnormal_muscle_regeneration1.36905560
43MP0005187_abnormal_penis_morphology1.35675083
44MP0009250_abnormal_appendicular_skeleto1.35092811
45MP0002295_abnormal_pulmonary_circulatio1.34493363
46MP0002106_abnormal_muscle_physiology1.33669597
47MP0004145_abnormal_muscle_electrophysio1.26656250
48MP0005595_abnormal_vascular_smooth1.24440802
49MP0001299_abnormal_eye_distance/1.23650502
50MP0000230_abnormal_systemic_arterial1.22632616
51MP0006072_abnormal_retinal_apoptosis1.21256091
52MP0000566_synostosis1.19967305
53MP0000579_abnormal_nail_morphology1.19686544
54MP0003122_maternal_imprinting1.16158475
55MP0004130_abnormal_muscle_cell1.14398994
56MP0010030_abnormal_orbit_morphology1.07886033
57MP0005409_darkened_coat_color1.07769843
58MP0003567_abnormal_fetal_cardiomyocyte1.07465333
59MP0003787_abnormal_imprinting1.07342250
60MP0005083_abnormal_biliary_tract1.06523939
61MP0002009_preneoplasia1.06304021
62MP0000462_abnormal_digestive_system1.04440684
63MP0000266_abnormal_heart_morphology1.04423882
64MP0010352_gastrointestinal_tract_polyps1.03908940
65MP0003935_abnormal_craniofacial_develop1.02951691
66MP0002822_catalepsy1.01490881
67MP0004233_abnormal_muscle_weight0.98590454
68MP0003942_abnormal_urinary_system0.98492908
69MP0002128_abnormal_blood_circulation0.97422657
70MP0000759_abnormal_skeletal_muscle0.96860049
71MP0000049_abnormal_middle_ear0.96176351
72MP0001270_distended_abdomen0.95972102
73MP0005248_abnormal_Harderian_gland0.95452533
74MP0002938_white_spotting0.95231106
75MP0005508_abnormal_skeleton_morphology0.95044787
76MP0001188_hyperpigmentation0.94856895
77MP0000372_irregular_coat_pigmentation0.94511706
78MP0010234_abnormal_vibrissa_follicle0.94140861
79MP0004510_myositis0.93043874
80MP0003045_fibrosis0.93010014
81MP0002269_muscular_atrophy0.92730050
82MP0003937_abnormal_limbs/digits/tail_de0.90606747
83MP0002925_abnormal_cardiovascular_devel0.88308466
84MP0000534_abnormal_ureter_morphology0.86689305
85MP0006054_spinal_hemorrhage0.85213057
86MP0005375_adipose_tissue_phenotype0.84404249
87MP0002249_abnormal_larynx_morphology0.84307800
88MP0001661_extended_life_span0.84277793
89MP0000428_abnormal_craniofacial_morphol0.83037465
90MP0005551_abnormal_eye_electrophysiolog0.80357320
91MP0000747_muscle_weakness0.79785611
92MP0000003_abnormal_adipose_tissue0.79107241
93MP0002638_abnormal_pupillary_reflex0.78821677
94MP0001614_abnormal_blood_vessel0.78542541
95MP0000537_abnormal_urethra_morphology0.78218607
96MP0003705_abnormal_hypodermis_morpholog0.77593133
97MP0005171_absent_coat_pigmentation0.76583110
98MP0005165_increased_susceptibility_to0.76262945
99MP0003984_embryonic_growth_retardation0.76025780
100MP0005257_abnormal_intraocular_pressure0.75432386
101MP0002088_abnormal_embryonic_growth/wei0.73991790
102MP0002332_abnormal_exercise_endurance0.73709667
103MP0002697_abnormal_eye_size0.73647385
104MP0004134_abnormal_chest_morphology0.73189545
105MP0000163_abnormal_cartilage_morphology0.73175809
106MP0000013_abnormal_adipose_tissue0.72145735
107MP0003283_abnormal_digestive_organ0.71768953
108MP0002282_abnormal_trachea_morphology0.71273184
109MP0002133_abnormal_respiratory_system0.71008332
110MP0005388_respiratory_system_phenotype0.71008332
111MP0000733_abnormal_muscle_development0.70997269
112MP0000762_abnormal_tongue_morphology0.70130768
113MP0009780_abnormal_chondrocyte_physiolo0.68058572
114MP0003121_genomic_imprinting0.66645171
115MP0003221_abnormal_cardiomyocyte_apopto0.65850577
116MP0005367_renal/urinary_system_phenotyp0.64979782
117MP0000516_abnormal_urinary_system0.64979782
118MP0002116_abnormal_craniofacial_bone0.64172321
119MP0003566_abnormal_cell_adhesion0.64168911
120MP0008004_abnormal_stomach_pH0.61025193
121MP0005666_abnormal_adipose_tissue0.60715356
122MP0002896_abnormal_bone_mineralization0.59670354
123MP0005253_abnormal_eye_physiology0.59140792
124MP0002090_abnormal_vision0.58358207
125MP0009697_abnormal_copulation0.57644521
126MP0008057_abnormal_DNA_replication0.57430876
127MP0001984_abnormal_olfaction0.54633562
128MP0010678_abnormal_skin_adnexa0.54564160
129MP0003091_abnormal_cell_migration0.53636547
130MP0000383_abnormal_hair_follicle0.51353327
131MP0005380_embryogenesis_phenotype0.50192506
132MP0001672_abnormal_embryogenesis/_devel0.50192506

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.41118927
2Atrial fibrillation (HP:0005110)4.76206801
3Primary atrial arrhythmia (HP:0001692)4.37136206
4Ventricular tachycardia (HP:0004756)4.30652256
5Broad metatarsal (HP:0001783)4.27152642
6Calf muscle hypertrophy (HP:0008981)4.22086236
7Supraventricular arrhythmia (HP:0005115)4.15582269
8Supraventricular tachycardia (HP:0004755)4.13508905
9Right ventricular cardiomyopathy (HP:0011663)4.05678447
10Abnormality of the calf musculature (HP:0001430)4.03098808
11Aortic aneurysm (HP:0004942)4.02171052
12Syncope (HP:0001279)3.98973175
13Prolonged QT interval (HP:0001657)3.83869717
14Asymmetric septal hypertrophy (HP:0001670)3.78844492
15Lipoatrophy (HP:0100578)3.77587623
16Muscle hypertrophy of the lower extremities (HP:0008968)3.69346316
17Pulmonary artery stenosis (HP:0004415)3.42754124
18Dysmetric saccades (HP:0000641)3.41119030
19Aortic dissection (HP:0002647)3.36497649
20Abnormality of the left ventricular outflow tract (HP:0011103)3.31450922
21Subaortic stenosis (HP:0001682)3.31450922
22Muscle fiber splitting (HP:0003555)3.30807767
23Midline defect of the nose (HP:0004122)3.15380914
24Hypoplastic ischia (HP:0003175)3.00464683
25Blue irides (HP:0000635)2.96922006
26Dilated cardiomyopathy (HP:0001644)2.94716077
27Short 4th metacarpal (HP:0010044)2.93408084
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.93408084
29Abnormality of the 4th metacarpal (HP:0010012)2.82687269
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.77460852
31Distal lower limb muscle weakness (HP:0009053)2.76911605
32Abnormality of the ischium (HP:0003174)2.74479902
33Abnormality of the parietal bone (HP:0002696)2.73685086
34Short hallux (HP:0010109)2.72881651
35Chorioretinal atrophy (HP:0000533)2.72377001
36Ragged-red muscle fibers (HP:0003200)2.67270626
37Ventricular arrhythmia (HP:0004308)2.62288836
38Hyporeflexia of lower limbs (HP:0002600)2.60859159
39Shallow orbits (HP:0000586)2.60010144
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.58598352
41Osteolytic defects of the hand bones (HP:0009699)2.58598352
42Areflexia of lower limbs (HP:0002522)2.54640004
43Exercise-induced myalgia (HP:0003738)2.48154538
44Bundle branch block (HP:0011710)2.46600293
45Aplasia/Hypoplasia of the hallux (HP:0008362)2.39638940
46EMG: neuropathic changes (HP:0003445)2.38921694
47Increased connective tissue (HP:0009025)2.38175986
48Abnormality of the tricuspid valve (HP:0001702)2.36785446
49Abnormal EKG (HP:0003115)2.34930660
50Aneurysm (HP:0002617)2.31711579
51Cerebral aneurysm (HP:0004944)2.30994723
52Ventricular fibrillation (HP:0001663)2.27823695
53Stroke (HP:0001297)2.26409814
54Exercise-induced muscle cramps (HP:0003710)2.25444876
55Bone cyst (HP:0012062)2.25442839
56Ankle contracture (HP:0006466)2.24357484
57Protrusio acetabuli (HP:0003179)2.23712682
58Premature rupture of membranes (HP:0001788)2.18677373
59Limited hip movement (HP:0008800)2.18643427
60Hip contracture (HP:0003273)2.17455812
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.15508341
62Submucous cleft hard palate (HP:0000176)2.14431456
63Vitreoretinal degeneration (HP:0000655)2.14074166
64Congenital sensorineural hearing impairment (HP:0008527)2.10700175
65Vascular tortuosity (HP:0004948)2.09518141
66Aplasia cutis congenita (HP:0001057)2.09272165
67Palpitations (HP:0001962)2.09037289
68Fair hair (HP:0002286)2.08188703
69Heart block (HP:0012722)2.06046919
70Short chin (HP:0000331)2.05615130
71Difficulty running (HP:0009046)2.04894616
72Myotonia (HP:0002486)2.04437179
73Spinal rigidity (HP:0003306)2.02686123
74Abnormal atrioventricular conduction (HP:0005150)2.01147939
75Hypoplastic left heart (HP:0004383)2.00259781
76Type 1 muscle fiber predominance (HP:0003803)1.99451379
77Neck muscle weakness (HP:0000467)1.98955518
78EMG: myopathic abnormalities (HP:0003458)1.98397810
79Scapular winging (HP:0003691)1.97914557
80Atrioventricular block (HP:0001678)1.93383051
81Bell-shaped thorax (HP:0001591)1.93122485
82Impaired pain sensation (HP:0007328)1.92320942
83Abnormality of pain sensation (HP:0010832)1.92320942
84Mesomelia (HP:0003027)1.91466304
85Abnormality of the nasal septum (HP:0000419)1.90981836
86Wormian bones (HP:0002645)1.90912615
87Left ventricular hypertrophy (HP:0001712)1.90843356
88Wrist flexion contracture (HP:0001239)1.89636301
89Abnormality of the right ventricle (HP:0001707)1.88647535
90Mitral stenosis (HP:0001718)1.87933841
91Palmoplantar keratoderma (HP:0000982)1.86871105
92Trigonocephaly (HP:0000243)1.86628500
93Bradycardia (HP:0001662)1.85702782
94Bladder diverticulum (HP:0000015)1.85582352
95Sudden cardiac death (HP:0001645)1.85398731
96Increased variability in muscle fiber diameter (HP:0003557)1.85358025
97Abnormality of the foot musculature (HP:0001436)1.84931625
98Nasolacrimal duct obstruction (HP:0000579)1.84720991
99Steppage gait (HP:0003376)1.84640445
100Abnormal auditory evoked potentials (HP:0006958)1.83718166
101Rimmed vacuoles (HP:0003805)1.83502070
102Overgrowth (HP:0001548)1.82518197
103Exostoses (HP:0100777)1.82010980
104Mildly elevated creatine phosphokinase (HP:0008180)1.81632376
105Vertebral arch anomaly (HP:0008438)1.81419643
106Knee flexion contracture (HP:0006380)1.80475953
107Rectal prolapse (HP:0002035)1.79363202
108Abnormality of glycolysis (HP:0004366)1.79126527
109Pheochromocytoma (HP:0002666)1.78510396
110Hypoventilation (HP:0002791)1.73659194
111Myoglobinuria (HP:0002913)1.73344087
112Toxemia of pregnancy (HP:0100603)1.72466885
113Scotoma (HP:0000575)1.71949788
114Muscular dystrophy (HP:0003560)1.70965385
115Lymphangioma (HP:0100764)1.70381367
116Centrally nucleated skeletal muscle fibers (HP:0003687)1.69947722
117Hypoplasia of the iris (HP:0007676)1.69296390
118Cerebellar dysplasia (HP:0007033)1.68499516
119Elbow flexion contracture (HP:0002987)1.68438745
120Central scotoma (HP:0000603)1.68007540
121Abnormality of alanine metabolism (HP:0010916)1.66872325
122Hyperalaninemia (HP:0003348)1.66872325
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66872325
124Broad ribs (HP:0000885)1.65893204
125Potter facies (HP:0002009)1.65803096
126Facial shape deformation (HP:0011334)1.65803096
127Abnormality of incisor morphology (HP:0011063)1.65650807
128Preaxial foot polydactyly (HP:0001841)1.65270582
129Papillary thyroid carcinoma (HP:0002895)1.64843545
130Wide anterior fontanel (HP:0000260)1.64628187
131Mild short stature (HP:0003502)1.63980408
132Alkalosis (HP:0001948)1.63774890
133Increased serum pyruvate (HP:0003542)1.63679835
134Mesangial abnormality (HP:0001966)1.60744172
135Abnormality of the lacrimal duct (HP:0011481)1.60380837
136Congenital stationary night blindness (HP:0007642)1.59683797
137Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.58625404
138Follicular hyperkeratosis (HP:0007502)1.58341911
139Abnormality of the nasolacrimal system (HP:0000614)1.58221705
140Aplasia involving bones of the extremities (HP:0009825)1.55989316
141Aplasia of the phalanges of the hand (HP:0009802)1.55989316
142Congestive heart failure (HP:0001635)1.55049428
143White forelock (HP:0002211)1.53662709
144Generalized muscle weakness (HP:0003324)1.52849464
145Increased circulating renin level (HP:0000848)1.51238669
146Subacute progressive viral hepatitis (HP:0006572)1.50239195
147Soft skin (HP:0000977)1.50050951
148Foot dorsiflexor weakness (HP:0009027)1.48167624
149Proximal amyotrophy (HP:0007126)1.47156564

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK5.53131944
2DMPK3.75051735
3TTN3.06723451
4LMTK22.93174092
5ZAK2.84764001
6TIE12.83024666
7INSRR2.68217480
8LATS12.64964711
9STK38L2.49395748
10OBSCN2.44779620
11PDGFRA2.43596147
12MST1R2.28429383
13EPHB22.28030827
14NUAK12.04899975
15PIK3CA2.03382677
16ACVR1B1.89638948
17PHKG21.89394080
18PHKG11.89394080
19PAK31.82984017
20AKT31.82202332
21EPHA31.73850046
22EEF2K1.62902422
23WNK41.59505870
24GRK71.59160366
25DDR21.57444491
26CDC42BPA1.56981154
27ROCK11.53759493
28FRK1.51134870
29NEK91.42092835
30BRSK21.41087908
31OXSR11.40235478
32STK241.39132939
33WNK11.38051323
34NEK11.37012890
35MKNK11.31552202
36PAK21.28388781
37CASK1.24013342
38PBK1.21782735
39PRKAA21.16054918
40MUSK1.14806964
41STK391.14048687
42PRKD11.13908967
43RIPK11.10855253
44FGFR21.09621299
45FER1.08901655
46NEK61.03784254
47STK41.00801746
48TGFBR21.00662688
49MAPKAPK51.00425336
50PDK40.99623644
51PDK30.99623644
52PDGFRB0.99235344
53MAPK120.99218730
54MARK10.98258878
55PRKCE0.97321096
56LATS20.91679563
57CAMK2D0.88818018
58RPS6KB20.85736128
59GRK10.85221882
60SIK10.85063776
61TGFBR10.84690783
62PINK10.83647155
63PRKAA10.81197162
64TRPM70.78183905
65MARK20.77619767
66ADRBK10.75791503
67PKN10.75374699
68SGK20.74602621
69MTOR0.72316244
70CAMK1G0.71968307
71STK380.70812208
72AKT20.70181602
73STK110.67390619
74CAMK2A0.67132774
75PRKCH0.67125084
76CAMK10.65960655
77CAMK40.65110759
78ICK0.64872999
79SGK4940.64852102
80SGK2230.64852102
81WEE10.62570021
82CDK90.60110271
83TRIB30.59471573
84MAP2K70.58252443
85CAMK2B0.57394850
86CAMKK20.54724189
87ROCK20.54685841
88MAPK70.54079396
89ILK0.54045012
90MET0.53854661
91PDK20.53753738
92CDK30.53722924
93MAP3K60.53376652
94SGK30.52633269
95ERBB20.52453053
96PRKD20.52018720
97PRKG10.50825950
98CAMK1D0.50279604
99PRKACB0.50185605
100STK30.48839877
101PTK2B0.48783061
102BRD40.48470858
103MAPKAPK30.47283220
104ERBB30.46895868
105MAP3K70.46471133
106CAMK2G0.46269822
107TTK0.45990359
108MAPK40.45484991
109FGFR10.44957154
110FGFR30.43547597
111PRKG20.43390436
112BMPR20.42797088
113RPS6KA50.42103285
114PRKD30.41944614
115PKN20.41486211
116* PRKACA0.39879934
117NTRK10.39164559
118MAPK110.38998690
119PIK3CG0.38083428
120SGK10.37780347
121LIMK10.36519953
122NLK0.34195301
123MELK0.34045489
124RPS6KL10.33009006
125RPS6KC10.33009006
126CDK60.32979844
127GSK3A0.32723875
128PTK20.32501706
129TLK10.32245011
130RET0.31790160
131KDR0.31430443
132SCYL20.30732757
133RPS6KA10.29612685
134PNCK0.29383974
135MAP3K40.28286081
136ERBB40.27793396
137MAPK130.26572542
138MAP2K10.25522758
139IGF1R0.24758126
140BCR0.23352106
141BMPR1B0.22923328
142PRKACG0.20251340

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054143.94958748
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.71232928
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.21977769
4Cardiac muscle contraction_Homo sapiens_hsa042602.49709781
5ECM-receptor interaction_Homo sapiens_hsa045122.48560476
6Arginine biosynthesis_Homo sapiens_hsa002202.44461903
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.39854085
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.27022575
9Nitrogen metabolism_Homo sapiens_hsa009102.23939704
10Vascular smooth muscle contraction_Homo sapiens_hsa042702.04522106
11Focal adhesion_Homo sapiens_hsa045102.04285971
12* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.76910782
13Adherens junction_Homo sapiens_hsa045201.59253281
14Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58112855
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56058466
16Pyruvate metabolism_Homo sapiens_hsa006201.52478320
17Phototransduction_Homo sapiens_hsa047441.46316738
18* Renin secretion_Homo sapiens_hsa049241.44863694
19Protein digestion and absorption_Homo sapiens_hsa049741.44487592
20Ovarian steroidogenesis_Homo sapiens_hsa049131.40480095
21Viral myocarditis_Homo sapiens_hsa054161.36960642
22Propanoate metabolism_Homo sapiens_hsa006401.30859826
23* cAMP signaling pathway_Homo sapiens_hsa040241.29096690
24Carbon metabolism_Homo sapiens_hsa012001.28176589
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25361727
26Oxytocin signaling pathway_Homo sapiens_hsa049211.24929582
27Basal cell carcinoma_Homo sapiens_hsa052171.22954583
28TGF-beta signaling pathway_Homo sapiens_hsa043501.22462883
29Amoebiasis_Homo sapiens_hsa051461.20491496
30Biosynthesis of amino acids_Homo sapiens_hsa012301.20266030
31Gap junction_Homo sapiens_hsa045401.20082249
32Axon guidance_Homo sapiens_hsa043601.18985587
33PPAR signaling pathway_Homo sapiens_hsa033201.18025832
34Calcium signaling pathway_Homo sapiens_hsa040201.15690762
35Circadian entrainment_Homo sapiens_hsa047131.15642145
36Insulin secretion_Homo sapiens_hsa049111.14008481
37Tight junction_Homo sapiens_hsa045301.12880523
38Dorso-ventral axis formation_Homo sapiens_hsa043201.09993618
39Hedgehog signaling pathway_Homo sapiens_hsa043401.09327757
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09256409
41Fatty acid degradation_Homo sapiens_hsa000711.04455781
42Melanoma_Homo sapiens_hsa052181.03654033
43Cocaine addiction_Homo sapiens_hsa050301.01091761
44Fatty acid metabolism_Homo sapiens_hsa012120.99026977
45Cholinergic synapse_Homo sapiens_hsa047250.98769189
46Bile secretion_Homo sapiens_hsa049760.98634281
47Proteoglycans in cancer_Homo sapiens_hsa052050.97667270
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97484095
49Salivary secretion_Homo sapiens_hsa049700.96047153
50Lysine degradation_Homo sapiens_hsa003100.92569132
51Parkinsons disease_Homo sapiens_hsa050120.91902055
52Gastric acid secretion_Homo sapiens_hsa049710.91710583
53Phenylalanine metabolism_Homo sapiens_hsa003600.91560944
54Serotonergic synapse_Homo sapiens_hsa047260.91012573
55Wnt signaling pathway_Homo sapiens_hsa043100.90722106
56Hippo signaling pathway_Homo sapiens_hsa043900.90374535
57Rap1 signaling pathway_Homo sapiens_hsa040150.85245466
58Alcoholism_Homo sapiens_hsa050340.83751980
59Alzheimers disease_Homo sapiens_hsa050100.82537092
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82355256
61PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82248213
62Fatty acid biosynthesis_Homo sapiens_hsa000610.81656089
63Taste transduction_Homo sapiens_hsa047420.80840688
64Small cell lung cancer_Homo sapiens_hsa052220.80828590
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80571330
66Mineral absorption_Homo sapiens_hsa049780.80553050
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80355481
68Oxidative phosphorylation_Homo sapiens_hsa001900.80196135
69Renal cell carcinoma_Homo sapiens_hsa052110.79398990
70Long-term depression_Homo sapiens_hsa047300.79219761
71Systemic lupus erythematosus_Homo sapiens_hsa053220.78845282
72Circadian rhythm_Homo sapiens_hsa047100.77970968
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76561266
74Pathways in cancer_Homo sapiens_hsa052000.76316990
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76139685
76ABC transporters_Homo sapiens_hsa020100.75313811
77Amphetamine addiction_Homo sapiens_hsa050310.75253431
78Notch signaling pathway_Homo sapiens_hsa043300.75129992
79Fatty acid elongation_Homo sapiens_hsa000620.74566845
80MicroRNAs in cancer_Homo sapiens_hsa052060.74406960
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73781111
82GnRH signaling pathway_Homo sapiens_hsa049120.72385073
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72168588
84Type II diabetes mellitus_Homo sapiens_hsa049300.72125776
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71728265
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71562883
87Ras signaling pathway_Homo sapiens_hsa040140.71409954
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70532889
89Platelet activation_Homo sapiens_hsa046110.69958361
90Pancreatic secretion_Homo sapiens_hsa049720.68099330
91Tryptophan metabolism_Homo sapiens_hsa003800.65981078
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65980941
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65795468
94Insulin resistance_Homo sapiens_hsa049310.65720576
95Glutamatergic synapse_Homo sapiens_hsa047240.63700889
96Melanogenesis_Homo sapiens_hsa049160.63401541
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.62829217
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.62356181
99Dopaminergic synapse_Homo sapiens_hsa047280.62321082
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61392217
101Estrogen signaling pathway_Homo sapiens_hsa049150.60393874
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.60316060
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59265744
104* Morphine addiction_Homo sapiens_hsa050320.59097363
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57092123
106MAPK signaling pathway_Homo sapiens_hsa040100.57087580
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.56580092
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56358664
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55819820
110Prostate cancer_Homo sapiens_hsa052150.55520807
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54342102
112Huntingtons disease_Homo sapiens_hsa050160.53778645
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53769496
114Glucagon signaling pathway_Homo sapiens_hsa049220.50139434
115Choline metabolism in cancer_Homo sapiens_hsa052310.49469198
116AMPK signaling pathway_Homo sapiens_hsa041520.49259374
117Arginine and proline metabolism_Homo sapiens_hsa003300.48239486
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47726463
119GABAergic synapse_Homo sapiens_hsa047270.44965416
120mTOR signaling pathway_Homo sapiens_hsa041500.44594530
121Thyroid hormone synthesis_Homo sapiens_hsa049180.41957716
122Tyrosine metabolism_Homo sapiens_hsa003500.41767085
123Sulfur metabolism_Homo sapiens_hsa009200.40662943
124Glioma_Homo sapiens_hsa052140.40449917
125Insulin signaling pathway_Homo sapiens_hsa049100.40063634
126Non-homologous end-joining_Homo sapiens_hsa034500.39780703
127Butanoate metabolism_Homo sapiens_hsa006500.39478592
128Fat digestion and absorption_Homo sapiens_hsa049750.39050869
129Pentose phosphate pathway_Homo sapiens_hsa000300.38629761
130Linoleic acid metabolism_Homo sapiens_hsa005910.35731743
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35157687
132FoxO signaling pathway_Homo sapiens_hsa040680.34787877
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.33402041
134Complement and coagulation cascades_Homo sapiens_hsa046100.31812574
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30495251

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