PDE3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.03857053
2regulation of gamma-delta T cell differentiation (GO:0045586)5.51929330
3negative T cell selection (GO:0043383)5.24662738
4L-phenylalanine catabolic process (GO:0006559)5.10934538
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.10934538
6valine metabolic process (GO:0006573)5.08866761
7regulation of gamma-delta T cell activation (GO:0046643)5.01123576
8negative thymic T cell selection (GO:0045060)4.96383352
9low-density lipoprotein particle clearance (GO:0034383)4.92273997
10regulation of sequestering of triglyceride (GO:0010889)4.91636225
11positive regulation of fatty acid beta-oxidation (GO:0032000)4.80442054
12complement activation, alternative pathway (GO:0006957)4.75285105
13alpha-linolenic acid metabolic process (GO:0036109)4.74608767
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.69888330
15L-phenylalanine metabolic process (GO:0006558)4.69888330
16regulation of B cell receptor signaling pathway (GO:0050855)4.52313040
17positive regulation of granulocyte differentiation (GO:0030854)4.51952003
18response to interleukin-15 (GO:0070672)4.50796115
19aromatic amino acid family catabolic process (GO:0009074)4.41288064
20activated T cell proliferation (GO:0050798)4.39576793
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.39336006
22urea metabolic process (GO:0019627)4.38046944
23urea cycle (GO:0000050)4.38046944
24triglyceride catabolic process (GO:0019433)4.37025362
25positive T cell selection (GO:0043368)4.34331867
26triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.34054333
27negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.33353953
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.26009215
29neutral lipid catabolic process (GO:0046461)4.23579075
30acylglycerol catabolic process (GO:0046464)4.23579075
31biotin metabolic process (GO:0006768)4.22587301
32regulation of triglyceride catabolic process (GO:0010896)4.18197764
33positive regulation of fatty acid oxidation (GO:0046321)4.11926464
34cellular response to interleukin-15 (GO:0071350)4.10758727
35acylglycerol homeostasis (GO:0055090)4.10044285
36triglyceride homeostasis (GO:0070328)4.10044285
37fatty acid beta-oxidation (GO:0006635)4.07514525
38plasma lipoprotein particle clearance (GO:0034381)4.01485939
39nitrogen cycle metabolic process (GO:0071941)3.96392092
40sulfur amino acid catabolic process (GO:0000098)3.95728070
41fatty acid transmembrane transport (GO:1902001)3.94912217
42interferon-gamma production (GO:0032609)3.94435571
43positive regulation of lipid catabolic process (GO:0050996)3.91318156
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.87910972
45peptidyl-glutamic acid carboxylation (GO:0017187)3.84648234
46protein carboxylation (GO:0018214)3.84648234
47negative regulation of T cell mediated immunity (GO:0002710)3.83802828
48fatty acid oxidation (GO:0019395)3.83100198
49regulation of fatty acid beta-oxidation (GO:0031998)3.82846647
50phospholipid homeostasis (GO:0055091)3.77132337
51lipid oxidation (GO:0034440)3.74669418
52indole-containing compound catabolic process (GO:0042436)3.74341640
53indolalkylamine catabolic process (GO:0046218)3.74341640
54tryptophan catabolic process (GO:0006569)3.74341640
55fatty acid catabolic process (GO:0009062)3.74294754
56T cell migration (GO:0072678)3.70722047
57tryptophan metabolic process (GO:0006568)3.70208107
58regulation of protein activation cascade (GO:2000257)3.68580619
59negative regulation of execution phase of apoptosis (GO:1900118)3.67559899
60regulation of cholesterol storage (GO:0010885)3.65723488
61T cell selection (GO:0045058)3.64882411
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.59485577
63regulation of regulatory T cell differentiation (GO:0045589)3.57589216
64phospholipid efflux (GO:0033700)3.57062641
65positive thymic T cell selection (GO:0045059)3.56871187
66tolerance induction (GO:0002507)3.56435840
67phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.54388375
68negative regulation of lipase activity (GO:0060192)3.54175109
69bile acid biosynthetic process (GO:0006699)3.53021669
70regulation of complement activation (GO:0030449)3.52966839
71tyrosine metabolic process (GO:0006570)3.52230558
72regulation of granulocyte differentiation (GO:0030852)3.51421064
73bile acid metabolic process (GO:0008206)3.50394903
74antigen processing and presentation of endogenous antigen (GO:0019883)3.45280827
75negative regulation of lymphocyte mediated immunity (GO:0002707)3.44143154
76lipid storage (GO:0019915)3.43916917
77cytolysis (GO:0019835)3.43658180
78brown fat cell differentiation (GO:0050873)3.42442833
79carnitine shuttle (GO:0006853)3.41951601
80cellular extravasation (GO:0045123)3.41492060
81homocysteine metabolic process (GO:0050667)3.40260118
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.39219018
83fatty acid homeostasis (GO:0055089)3.36621796
84positive regulation of glycolytic process (GO:0045821)3.35875517
85monocarboxylic acid catabolic process (GO:0072329)3.35549654
86kynurenine metabolic process (GO:0070189)3.35072433
87acetyl-CoA metabolic process (GO:0006084)3.34468729
88cellular response to ethanol (GO:0071361)3.34453656
89regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.31845543
90amino-acid betaine metabolic process (GO:0006577)3.31254893
91branched-chain amino acid metabolic process (GO:0009081)3.29881726
92reverse cholesterol transport (GO:0043691)3.27020265
93bile acid and bile salt transport (GO:0015721)3.26578173
94thymic T cell selection (GO:0045061)3.25849650
95cysteine metabolic process (GO:0006534)3.24766234
96high-density lipoprotein particle remodeling (GO:0034375)3.24192694
97lysine metabolic process (GO:0006553)3.21853752
98lysine catabolic process (GO:0006554)3.21853752
99establishment of protein localization to Golgi (GO:0072600)3.19856297
100negative regulation of granulocyte differentiation (GO:0030853)3.17940098
101positive regulation of fatty acid metabolic process (GO:0045923)3.17805288
102negative regulation of fibrinolysis (GO:0051918)3.16528973
103regulation of fatty acid oxidation (GO:0046320)3.15753575
104histone H3-K4 trimethylation (GO:0080182)3.14390135
105antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.13188005
106tricarboxylic acid metabolic process (GO:0072350)3.12195113
107aromatic amino acid family metabolic process (GO:0009072)3.11916527
108negative regulation of lipid storage (GO:0010888)3.11019268
109regulation of fibrinolysis (GO:0051917)3.10948396
110complement activation (GO:0006956)3.10906775
111glycerolipid catabolic process (GO:0046503)3.10733530
112glyoxylate metabolic process (GO:0046487)3.09896695
1132-oxoglutarate metabolic process (GO:0006103)3.09648102
114triglyceride metabolic process (GO:0006641)3.04742265
115plasma lipoprotein particle assembly (GO:0034377)3.04580143
116serine family amino acid catabolic process (GO:0009071)3.03244058
117positive regulation of cholesterol transport (GO:0032376)3.02801053
118positive regulation of sterol transport (GO:0032373)3.02801053
119branched-chain amino acid catabolic process (GO:0009083)3.02678664
120negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.01353371
121negative regulation of cell killing (GO:0031342)3.01353371
122regulation of triglyceride metabolic process (GO:0090207)3.01333310
123white fat cell differentiation (GO:0050872)3.00336742
124short-chain fatty acid metabolic process (GO:0046459)3.00299672
125regulation of alpha-beta T cell proliferation (GO:0046640)2.99614793
126protein targeting to Golgi (GO:0000042)2.98700610
127complement activation, classical pathway (GO:0006958)2.97557412
128plasma lipoprotein particle remodeling (GO:0034369)2.96444353
129protein-lipid complex remodeling (GO:0034368)2.96444353
130macromolecular complex remodeling (GO:0034367)2.96444353
131negative regulation of protein autophosphorylation (GO:0031953)2.95505782
132regulation of macrophage derived foam cell differentiation (GO:0010743)2.94481403
133acylglycerol metabolic process (GO:0006639)2.94137042
134histone H3-K36 demethylation (GO:0070544)2.93976276
135indolalkylamine metabolic process (GO:0006586)2.93363119
136alpha-amino acid catabolic process (GO:1901606)2.93112162
137alpha-beta T cell differentiation (GO:0046632)2.92583791
138organic acid catabolic process (GO:0016054)2.89994111
139negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.88525316
140regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.86115034
141positive regulation of alpha-beta T cell proliferation (GO:0046641)2.85592585
142diacylglycerol metabolic process (GO:0046339)2.85123952
143regulation of isotype switching to IgG isotypes (GO:0048302)2.77317505
144hepatocyte apoptotic process (GO:0097284)2.76561207
145production of molecular mediator involved in inflammatory response (GO:0002532)2.75636905
146retrograde transport, vesicle recycling within Golgi (GO:0000301)2.73875319
147B cell receptor signaling pathway (GO:0050853)2.72291039
148regulation of T cell tolerance induction (GO:0002664)2.71001881
149positive regulation of tolerance induction (GO:0002645)2.69803770
150negative regulation of leukocyte mediated immunity (GO:0002704)2.69746036
151dendritic cell migration (GO:0036336)2.67312155
152regulation of T cell mediated cytotoxicity (GO:0001914)2.66553408
153regulation of B cell differentiation (GO:0045577)2.66095335
154alpha-beta T cell activation (GO:0046631)2.65979950
155antigen processing and presentation via MHC class Ib (GO:0002475)2.64794902
156mast cell activation (GO:0045576)2.61534750
157leukocyte aggregation (GO:0070486)2.60823350
158negative regulation of adaptive immune response (GO:0002820)2.60012383
159T cell differentiation (GO:0030217)2.59795184
160monoubiquitinated protein deubiquitination (GO:0035520)2.59198415
161T cell receptor signaling pathway (GO:0050852)2.58530809
162protein K11-linked deubiquitination (GO:0035871)2.57393680
163negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.55976343
164cellular ketone body metabolic process (GO:0046950)2.54608833
165positive regulation of B cell differentiation (GO:0045579)2.52934957
166antigen receptor-mediated signaling pathway (GO:0050851)2.52524122
167neural tube formation (GO:0001841)2.52330258
168regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.52044394
169regulation of natural killer cell mediated immunity (GO:0002715)2.52044394
170regulation of tolerance induction (GO:0002643)2.51855998
171detection of molecule of bacterial origin (GO:0032490)2.47697564
172negative regulation of phagocytosis (GO:0050765)2.47186117
173CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.45258841
174microglial cell activation (GO:0001774)2.44384424
175regulation of leukocyte mediated cytotoxicity (GO:0001910)2.41877407
176positive regulation of T cell mediated cytotoxicity (GO:0001916)2.39739367
177Peyers patch development (GO:0048541)2.38805481
178mucosal-associated lymphoid tissue development (GO:0048537)2.38805481
179negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.37557635
180T cell proliferation (GO:0042098)2.37160462
181negative regulation of immunoglobulin mediated immune response (GO:0002890)2.36586069
182negative regulation of B cell mediated immunity (GO:0002713)2.36586069
183myeloid leukocyte mediated immunity (GO:0002444)2.36140501
184T-helper cell differentiation (GO:0042093)2.35242532
185CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.35242532
186regulation of interleukin-2 biosynthetic process (GO:0045076)2.33596654
187ketone body metabolic process (GO:1902224)2.33007701
188histone mRNA catabolic process (GO:0071044)2.32716410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.89729341
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.59105565
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.51620951
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.81954405
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.79171569
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.28031665
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.76151292
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.25594430
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.14914659
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.13084166
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.05974656
12GATA1_22025678_ChIP-Seq_K562_Human3.05341059
13IRF8_22096565_ChIP-ChIP_GC-B_Human3.02459918
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.97183202
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.70270607
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.47994455
17* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.45972175
18CLOCK_20551151_ChIP-Seq_293T_Human2.34776298
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06950842
20RUNX_20019798_ChIP-Seq_JUKART_Human2.00691408
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.96057730
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92079020
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89635268
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.87154940
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.81967917
26IGF1R_20145208_ChIP-Seq_DFB_Human1.77336504
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72078752
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.65586210
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.64332016
30* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64309083
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63084627
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57505488
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50353119
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.48426520
35ER_23166858_ChIP-Seq_MCF-7_Human1.47823378
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.46202226
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45307612
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44498740
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42837630
40TAF15_26573619_Chip-Seq_HEK293_Human1.40324544
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37483174
42* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.33752205
43CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31891193
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.31165192
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30864037
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26948504
47SCL_19346495_ChIP-Seq_HPC-7_Human1.25499676
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24726330
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.24132603
50ZNF274_21170338_ChIP-Seq_K562_Hela1.23504933
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22642486
52GBX2_23144817_ChIP-Seq_PC3_Human1.19236985
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17800314
54* STAT3_23295773_ChIP-Seq_U87_Human1.17213591
55MYB_26560356_Chip-Seq_TH2_Human1.17149402
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17128697
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16806146
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.16040066
59* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.14580128
60OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14469568
61PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14309059
62MYB_26560356_Chip-Seq_TH1_Human1.12646761
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12312555
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.10400652
65GATA3_27048872_Chip-Seq_THYMUS_Human1.10157848
66VDR_24787735_ChIP-Seq_THP-1_Human1.09050418
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08660655
68SPI1_23547873_ChIP-Seq_NB4_Human1.08656965
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.07631081
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06724682
71* SMRT_27268052_Chip-Seq_Bcells_Human1.06053054
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04802197
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.02244017
74SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01537859
75* HNF4A_19822575_ChIP-Seq_HepG2_Human1.01474959
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01437445
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00874213
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00127955
79* TCF4_23295773_ChIP-Seq_U87_Human1.00060786
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99192087
81BCAT_22108803_ChIP-Seq_LS180_Human0.97363617
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97173157
83* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96422343
84MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96324426
85FOXO3_23340844_ChIP-Seq_DLD1_Human0.95504433
86P300_19829295_ChIP-Seq_ESCs_Human0.95132598
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94589059
88NOTCH1_21737748_ChIP-Seq_TLL_Human0.94264487
89GATA2_21666600_ChIP-Seq_HMVEC_Human0.93583033
90GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93021858
91CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92991058
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92545569
93P53_22387025_ChIP-Seq_ESCs_Mouse0.91875022
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91871008
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91782664
96NANOG_18555785_Chip-Seq_ESCs_Mouse0.91653465
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91099832
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89459162
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89436605
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89436605
101GATA3_26560356_Chip-Seq_TH2_Human0.89246410
102SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89140147
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88471984
104TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.88403751
105FOXA1_25552417_ChIP-Seq_VCAP_Human0.87987848
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87594778
107E2F1_18555785_Chip-Seq_ESCs_Mouse0.87219021
108GATA2_19941826_ChIP-Seq_K562_Human0.87142620
109VDR_22108803_ChIP-Seq_LS180_Human0.87058092
110SMAD4_21799915_ChIP-Seq_A2780_Human0.86880461
111PU_27001747_Chip-Seq_BMDM_Mouse0.86288372
112CMYC_18555785_Chip-Seq_ESCs_Mouse0.86220205
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84708795
114CBP_20019798_ChIP-Seq_JUKART_Human0.84708795
115GATA1_19941826_ChIP-Seq_K562_Human0.84553951
116OCT4_18555785_Chip-Seq_ESCs_Mouse0.83449438
117SPI1_23127762_ChIP-Seq_K562_Human0.82702042
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81684345
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81546686
120* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79558323
121* TCF7_22412390_ChIP-Seq_EML_Mouse0.78082362
122MAF_26560356_Chip-Seq_TH1_Human0.77805494
123* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.76816400
124SMAD_19615063_ChIP-ChIP_OVARY_Human0.75250786
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75140763
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73814201
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.73334390
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73235676
129GATA2_22383799_ChIP-Seq_G1ME_Mouse0.72394835
130* UTX_26944678_Chip-Seq_JUKART_Human0.71974313
131MYC_22102868_ChIP-Seq_BL_Human0.71447975
132CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.70971854
133* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.70403294
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.70099295
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.68834680
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.65973712
137POU3F2_20337985_ChIP-ChIP_501MEL_Human0.65486758
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65144874
139GATA3_26560356_Chip-Seq_TH1_Human0.64908554
140GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.63886529
141CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.63711226
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63406071
143GATA4_25053715_ChIP-Seq_YYC3_Human0.63369574
144STAT4_19710469_ChIP-ChIP_TH1__Mouse0.62953419
145LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.62627882
146GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62591412
147MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.62559129
148LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.61998792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.20253888
2MP0005670_abnormal_white_adipose5.06303981
3MP0005365_abnormal_bile_salt4.69603570
4MP0005360_urolithiasis4.15312469
5MP0005085_abnormal_gallbladder_physiolo3.88013735
6MP0003252_abnormal_bile_duct3.36702762
7MP0003191_abnormal_cellular_cholesterol3.26748890
8MP0010329_abnormal_lipoprotein_level3.23374579
9MP0005666_abnormal_adipose_tissue3.03247150
10MP0002009_preneoplasia2.45769593
11MP0004130_abnormal_muscle_cell2.43276160
12MP0008875_abnormal_xenobiotic_pharmacok2.43238466
13MP0004185_abnormal_adipocyte_glucose2.42772268
14MP0000569_abnormal_digit_pigmentation2.39012889
15MP0008057_abnormal_DNA_replication2.33355649
16MP0003787_abnormal_imprinting2.31387724
17MP0000609_abnormal_liver_physiology2.24652583
18MP0005375_adipose_tissue_phenotype2.16232681
19* MP0002118_abnormal_lipid_homeostasis2.14777610
20MP0005075_abnormal_melanosome_morpholog2.13657176
21MP0000013_abnormal_adipose_tissue2.09930231
22MP0002971_abnormal_brown_adipose1.96351108
23MP0004381_abnormal_hair_follicle1.91590380
24MP0002138_abnormal_hepatobiliary_system1.90177603
25MP0008877_abnormal_DNA_methylation1.88531974
26MP0009840_abnormal_foam_cell1.83860931
27* MP0005334_abnormal_fat_pad1.79830487
28MP0003300_gastrointestinal_ulcer1.79612353
29MP0002876_abnormal_thyroid_physiology1.70376455
30MP0001666_abnormal_nutrient_absorption1.68854586
31MP0002877_abnormal_melanocyte_morpholog1.68248223
32* MP0002078_abnormal_glucose_homeostasis1.64397303
33MP0003195_calcinosis1.64240623
34MP0000703_abnormal_thymus_morphology1.63507470
35MP0005332_abnormal_amino_acid1.60614977
36MP0005535_abnormal_body_temperature1.59612788
37MP0003868_abnormal_feces_composition1.55305990
38MP0000003_abnormal_adipose_tissue1.52636101
39MP0002405_respiratory_system_inflammati1.52473643
40MP0003724_increased_susceptibility_to1.51387180
41MP0001764_abnormal_homeostasis1.49694236
42MP0002398_abnormal_bone_marrow1.46176918
43MP0000689_abnormal_spleen_morphology1.44833272
44MP0002163_abnormal_gland_morphology1.43908982
45MP0002837_dystrophic_cardiac_calcinosis1.43121592
46MP0002396_abnormal_hematopoietic_system1.42165366
47MP0005671_abnormal_response_to1.41621188
48* MP0002693_abnormal_pancreas_physiology1.40808666
49MP0003866_abnormal_defecation1.39796240
50* MP0009115_abnormal_fat_cell1.39411677
51MP0000716_abnormal_immune_system1.38424627
52MP0006082_CNS_inflammation1.37939655
53MP0002928_abnormal_bile_duct1.37778318
54MP0002166_altered_tumor_susceptibility1.36594508
55MP0001944_abnormal_pancreas_morphology1.34945454
56MP0001661_extended_life_span1.33872923
57MP0002970_abnormal_white_adipose1.33674696
58MP0009643_abnormal_urine_homeostasis1.33151113
59MP0009333_abnormal_splenocyte_physiolog1.31679378
60MP0005319_abnormal_enzyme/_coenzyme1.28956268
61MP0000015_abnormal_ear_pigmentation1.28684579
62MP0001835_abnormal_antigen_presentation1.27624253
63MP0002722_abnormal_immune_system1.25728110
64MP0005174_abnormal_tail_pigmentation1.24527863
65MP0003959_abnormal_lean_body1.24384784
66MP0005448_abnormal_energy_balance1.23013793
67MP0000372_irregular_coat_pigmentation1.22517475
68MP0003436_decreased_susceptibility_to1.21627356
69MP0002638_abnormal_pupillary_reflex1.19641324
70MP0005310_abnormal_salivary_gland1.17743652
71MP0005220_abnormal_exocrine_pancreas1.17456256
72MP0005464_abnormal_platelet_physiology1.15969752
73MP0003690_abnormal_glial_cell1.14826208
74MP0003045_fibrosis1.13254516
75MP0005058_abnormal_lysosome_morphology1.13237647
76MP0003828_pulmonary_edema1.12800278
77MP0004019_abnormal_vitamin_homeostasis1.12098973
78MP0003183_abnormal_peptide_metabolism1.11373062
79MP0008469_abnormal_protein_level1.10739499
80MP0005083_abnormal_biliary_tract1.07802184
81MP0009763_increased_sensitivity_to1.07294418
82MP0005379_endocrine/exocrine_gland_phen1.06435240
83MP0000598_abnormal_liver_morphology1.05498525
84MP0009780_abnormal_chondrocyte_physiolo1.04425012
85MP0003763_abnormal_thymus_physiology1.03706836
86* MP0005584_abnormal_enzyme/coenzyme_acti1.01687014
87MP0002909_abnormal_adrenal_gland1.01049573
88MP0005645_abnormal_hypothalamus_physiol1.00633408
89MP0001800_abnormal_humoral_immune1.00322975
90MP0003303_peritoneal_inflammation0.99465174
91MP0010155_abnormal_intestine_physiology0.98921371
92MP0002429_abnormal_blood_cell0.98214766
93MP0008961_abnormal_basal_metabolism0.97868611
94MP0003806_abnormal_nucleotide_metabolis0.97277835
95MP0002148_abnormal_hypersensitivity_rea0.97238927
96MP0000371_diluted_coat_color0.97199619
97MP0002254_reproductive_system_inflammat0.96999983
98MP0004883_abnormal_blood_vessel0.96585587
99MP0001986_abnormal_taste_sensitivity0.94962028
100MP0001873_stomach_inflammation0.94852593
101MP0001790_abnormal_immune_system0.94812928
102MP0005387_immune_system_phenotype0.94812928
103MP0002933_joint_inflammation0.93416396
104MP0003646_muscle_fatigue0.90827583
105MP0002419_abnormal_innate_immunity0.90706252
106MP0001851_eye_inflammation0.90000192
107* MP0009642_abnormal_blood_homeostasis0.89953031
108MP0005647_abnormal_sex_gland0.89934070
109* MP0003953_abnormal_hormone_level0.89264936
110MP0003172_abnormal_lysosome_physiology0.89124204
111MP0001756_abnormal_urination0.88993937
112MP0001845_abnormal_inflammatory_respons0.88294896
113MP0002006_tumorigenesis0.85240601
114MP0005000_abnormal_immune_tolerance0.84920336
115MP0008438_abnormal_cutaneous_collagen0.83508185
116MP0000685_abnormal_immune_system0.83104147
117MP0009697_abnormal_copulation0.82768208
118* MP0005452_abnormal_adipose_tissue0.82113264
119MP0002168_other_aberrant_phenotype0.81781539
120MP0002723_abnormal_immune_serum0.81251843
121MP0002998_abnormal_bone_remodeling0.76605081
122MP0001533_abnormal_skeleton_physiology0.76033138
123MP0005408_hypopigmentation0.73792236
124MP0002452_abnormal_antigen_presenting0.73558519
125MP0003186_abnormal_redox_activity0.73319418
126MP0001501_abnormal_sleep_pattern0.73065098
127MP0009764_decreased_sensitivity_to0.71659946
128MP0005025_abnormal_response_to0.71504381
129MP0001881_abnormal_mammary_gland0.70753625
130MP0003705_abnormal_hypodermis_morpholog0.70063790
131MP0009672_abnormal_birth_weight0.69799643
132MP0002420_abnormal_adaptive_immunity0.67694091
133MP0001819_abnormal_immune_cell0.67404035
134MP0001853_heart_inflammation0.66411750
135MP0009785_altered_susceptibility_to0.65785948
136MP0002136_abnormal_kidney_physiology0.65688991
137MP0009765_abnormal_xenobiotic_induced0.61173949

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)6.00146495
2Hypoglycemic coma (HP:0001325)5.19953106
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.55098965
4Stomatitis (HP:0010280)4.47730746
5Systemic lupus erythematosus (HP:0002725)4.33489016
6Xanthomatosis (HP:0000991)4.31458911
7Deep venous thrombosis (HP:0002625)4.29753402
8Abnormality of complement system (HP:0005339)4.28841614
9Prolonged partial thromboplastin time (HP:0003645)4.26307720
10Hypoglycemic seizures (HP:0002173)4.25889342
11Intrahepatic cholestasis (HP:0001406)4.25692216
12Ketosis (HP:0001946)3.95089392
13Hyperglycinuria (HP:0003108)3.86640742
14Epidermoid cyst (HP:0200040)3.82912405
15Joint hemorrhage (HP:0005261)3.82232273
16Hyperinsulinemic hypoglycemia (HP:0000825)3.79120096
17Oligomenorrhea (HP:0000876)3.74580366
18Ketoacidosis (HP:0001993)3.74384011
19Hyperlipoproteinemia (HP:0010980)3.71186239
20Abnormality of monocarboxylic acid metabolism (HP:0010996)3.70681228
21Eczematoid dermatitis (HP:0000976)3.69172169
22Abnormality of the common coagulation pathway (HP:0010990)3.66361407
23Abnormality of the intrinsic pathway (HP:0010989)3.62919724
24Hypoalphalipoproteinemia (HP:0003233)3.59295507
25Myocardial infarction (HP:0001658)3.58299747
26Insulin-resistant diabetes mellitus (HP:0000831)3.48671890
27Severe combined immunodeficiency (HP:0004430)3.48150523
28Thyroiditis (HP:0100646)3.47901343
29Glomerulonephritis (HP:0000099)3.47541557
30Optic neuritis (HP:0100653)3.46548366
31Retrobulbar optic neuritis (HP:0100654)3.46548366
32Myositis (HP:0100614)3.38027296
33Conjugated hyperbilirubinemia (HP:0002908)3.32388045
34Recurrent fungal infections (HP:0002841)3.30881059
35Abnormality of glycine metabolism (HP:0010895)3.30185027
36Abnormality of serine family amino acid metabolism (HP:0010894)3.30185027
37Hyperglycemia (HP:0003074)3.30039337
38Recurrent bacterial skin infections (HP:0005406)3.29508324
39Hypobetalipoproteinemia (HP:0003563)3.28067157
40Hypolipoproteinemia (HP:0010981)3.27476856
41Symptomatic seizures (HP:0011145)3.26231225
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.26174530
43Elevated erythrocyte sedimentation rate (HP:0003565)3.21666081
44Hyperammonemia (HP:0001987)3.15473494
45Hyperglycinemia (HP:0002154)3.09604126
46Gastrointestinal infarctions (HP:0005244)3.08793870
47Orchitis (HP:0100796)3.08409121
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.04968068
49Abnormality of fatty-acid metabolism (HP:0004359)3.01508693
50Recurrent abscess formation (HP:0002722)3.00644874
51Hematochezia (HP:0002573)2.94672295
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.87226271
53Hypertriglyceridemia (HP:0002155)2.86501409
54Chronic mucocutaneous candidiasis (HP:0002728)2.81623216
55Recurrent cutaneous fungal infections (HP:0011370)2.81623216
56Spontaneous hematomas (HP:0007420)2.76714868
57Limb hypertonia (HP:0002509)2.76674797
58Skin nodule (HP:0200036)2.74921831
59T lymphocytopenia (HP:0005403)2.72839158
60Insulin resistance (HP:0000855)2.67964189
61Hypercholesterolemia (HP:0003124)2.66134367
62Prolonged bleeding time (HP:0003010)2.65636563
63Recurrent gram-negative bacterial infections (HP:0005420)2.63005729
64Increased CSF protein (HP:0002922)2.62177437
65Recurrent skin infections (HP:0001581)2.61703837
66Generalized aminoaciduria (HP:0002909)2.61564877
67Pancreatitis (HP:0001733)2.59321451
68Combined immunodeficiency (HP:0005387)2.59039220
69Abnormality of T cell number (HP:0011839)2.58835801
70Abnormality of eosinophils (HP:0001879)2.57163753
71Leukocytosis (HP:0001974)2.54770010
72Renal cortical cysts (HP:0000803)2.54730624
73Abnormality of endocrine pancreas physiology (HP:0012093)2.51903024
74Abnormality of the pancreatic islet cells (HP:0006476)2.51903024
75Pancreatic islet-cell hyperplasia (HP:0004510)2.47982200
76Hemorrhage of the eye (HP:0011885)2.47784497
77Keratoconjunctivitis (HP:0001096)2.46099534
78Keratoconjunctivitis sicca (HP:0001097)2.46030826
79Pustule (HP:0200039)2.45823614
80Retinal atrophy (HP:0001105)2.45117372
81Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.44784352
82Late onset (HP:0003584)2.44779263
83Fat malabsorption (HP:0002630)2.43948632
84Abnormality of sulfur amino acid metabolism (HP:0004339)2.43313017
85Autoimmune hemolytic anemia (HP:0001890)2.41829424
86Encephalitis (HP:0002383)2.41735600
87Abnormality of proline metabolism (HP:0010907)2.41301615
88Hydroxyprolinuria (HP:0003080)2.41301615
89Panhypogammaglobulinemia (HP:0003139)2.40999206
90IgG deficiency (HP:0004315)2.40632432
91Abnormality of purine metabolism (HP:0004352)2.39593562
92Abnormality of T cell physiology (HP:0011840)2.38377979
93Mucopolysacchariduria (HP:0008155)2.37087720
94Urinary glycosaminoglycan excretion (HP:0003541)2.37087720
95Vasculitis (HP:0002633)2.36958088
96Stomach cancer (HP:0012126)2.36130124
97Chronic diarrhea (HP:0002028)2.33935007
98Acanthosis nigricans (HP:0000956)2.32373504
99Hemoptysis (HP:0002105)2.29335429
100Dysostosis multiplex (HP:0000943)2.28573241
101Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27446081
102Abnormality of polysaccharide metabolism (HP:0011012)2.27446081
103Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27446081
104Abnormality of the renal cortex (HP:0011035)2.25744864
105Hypochromic microcytic anemia (HP:0004840)2.24119622
106Nephritis (HP:0000123)2.23952156
107Hypoplasia of the thymus (HP:0000778)2.23727082
108Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22364496
109Pulmonary embolism (HP:0002204)2.22352691
110Abnormality of macrophages (HP:0004311)2.20060748
111Inflammation of the large intestine (HP:0002037)2.19744070
112Abnormality of methionine metabolism (HP:0010901)2.19263464
113Gingival bleeding (HP:0000225)2.19260329
114Abnormality of nucleobase metabolism (HP:0010932)2.18650173
115Recurrent viral infections (HP:0004429)2.18332502
116Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18077255
117Dicarboxylic aciduria (HP:0003215)2.18077255
118Lymphopenia (HP:0001888)2.17499751
119Gaze-evoked nystagmus (HP:0000640)2.15606174
120Fair hair (HP:0002286)2.14634746
121Congenital stationary night blindness (HP:0007642)2.14472369
122Joint swelling (HP:0001386)2.12556952
123Meningitis (HP:0001287)2.11332284
124Menorrhagia (HP:0000132)2.10621627
125Hyperventilation (HP:0002883)2.09627908
126Recurrent bronchitis (HP:0002837)2.08975727
127Eosinophilia (HP:0001880)2.07781205
128IgM deficiency (HP:0002850)2.05582293
129Neoplasm of the tracheobronchial system (HP:0100552)2.04722094
130Pulmonary infiltrates (HP:0002113)2.03873192
131Gingivitis (HP:0000230)2.03529176
132Hepatocellular carcinoma (HP:0001402)2.01516796
133Genetic anticipation (HP:0003743)2.01076536
134Hyperbilirubinemia (HP:0002904)2.00173271
135Arterial thrombosis (HP:0004420)2.00119842
136Granulocytopenia (HP:0001913)1.99314338
137Abnormal delayed hypersensitivity skin test (HP:0002963)1.98935398
138Abnormality of B cell number (HP:0010975)1.98169803
139Upper motor neuron abnormality (HP:0002127)1.97045558
140Decreased circulating renin level (HP:0003351)1.97031392
141Gastrointestinal inflammation (HP:0004386)1.95381777
142Abnormal platelet volume (HP:0011876)1.95323336
143Mitral stenosis (HP:0001718)1.94951883
144Episodic fever (HP:0001954)1.94580787
145Generalized hypopigmentation of hair (HP:0011358)1.94209230
146Cerebral aneurysm (HP:0004944)1.91008182
147Papilledema (HP:0001085)1.90982010
148Hypochromic anemia (HP:0001931)1.90311135
149Albinism (HP:0001022)1.89643003
150Epistaxis (HP:0000421)1.89267748
151Acute hepatic failure (HP:0006554)1.88954434
152Abnormality of serum amino acid levels (HP:0003112)1.88820003
153Metabolic acidosis (HP:0001942)1.88723600
154Myoglobinuria (HP:0002913)1.88530941
155Abnormality of cells of the lymphoid lineage (HP:0012140)1.88492843
156Hyperkalemia (HP:0002153)1.87641763
157Increased mean platelet volume (HP:0011877)1.87041765
158Intestinal atresia (HP:0011100)1.86556501
159Mediastinal lymphadenopathy (HP:0100721)1.86532167
160Glucose intolerance (HP:0000833)1.86363245
161Sensorimotor neuropathy (HP:0007141)1.85411083
162Enlarged kidneys (HP:0000105)1.84185242
163Attenuation of retinal blood vessels (HP:0007843)1.83085083
164Abnormality of T cells (HP:0002843)1.82573457
165Long foot (HP:0001833)1.82444673
166Chest pain (HP:0100749)1.82012012
167Elevated hepatic transaminases (HP:0002910)1.81401255
168Bone cyst (HP:0012062)1.81256785
169Abnormal rod and cone electroretinograms (HP:0008323)1.80568555
170Pigmentary retinal degeneration (HP:0001146)1.79656372
171Growth hormone excess (HP:0000845)1.79624083
172Abnormality of the fingertips (HP:0001211)1.79564311
173Striae distensae (HP:0001065)1.79458780
174Neonatal hypoglycemia (HP:0001998)1.78772553
175Alveolar cell carcinoma (HP:0006519)1.77972716
176Abnormal glucose tolerance (HP:0001952)1.77318946
177Abnormality of pyrimidine metabolism (HP:0004353)1.76763394
178Anorexia (HP:0002039)1.73547507
179Colitis (HP:0002583)1.71031972
180Slow saccadic eye movements (HP:0000514)1.70845010
181Progressive cerebellar ataxia (HP:0002073)1.70570944
182Truncal obesity (HP:0001956)1.69621695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.54920790
2CAMK1D3.68667256
3TGFBR23.50423941
4SIK12.99052009
5CAMKK22.74613549
6CAMK1G2.71364872
7BCKDK2.62754077
8FRK2.60533473
9TAOK32.57055389
10TRIB32.56863192
11FGFR42.49706065
12IRAK32.31943458
13MAPK152.27463211
14ERN12.21147707
15JAK12.20340671
16FGFR32.02940954
17TXK2.02822221
18ITK1.89980905
19MAP4K11.89786819
20RIPK41.84696842
21FES1.76409713
22TYK21.69178972
23ACVR1B1.62571055
24MAP4K21.60277753
25BLK1.58986153
26JAK31.54237450
27NEK91.50998135
28PKN21.49549726
29FLT31.44251894
30JAK21.43755037
31MAP3K141.41478751
32CSF1R1.39307029
33CAMKK11.31954575
34FGFR21.31625501
35YES11.28709876
36CDK91.28488925
37PTK61.23396249
38PRKAA21.20470670
39MAP3K101.19283210
40ZAP701.19147490
41CSK1.18262935
42IRAK11.17534568
43PIK3CG1.17491658
44CDK61.13791455
45PDK31.12399968
46PDK41.12399968
47PRKCH1.07770264
48HIPK21.07128862
49MARK31.06646600
50IRAK41.06287209
51EPHA31.04061780
52MAP2K61.03188959
53PASK0.99949240
54TRPM70.97660906
55LATS10.97021865
56TEC0.96156168
57PDK20.95799776
58NLK0.95326709
59GRK70.93731552
60MAPK110.90188034
61PRPF4B0.86221017
62PDK10.85449984
63ADRBK20.84586044
64SGK30.83085530
65STK110.80765032
66WNK10.78868167
67CAMK40.78431249
68PDGFRA0.78161848
69PINK10.76162436
70IKBKE0.75987298
71PRKAA10.75245844
72STK100.75219825
73IGF1R0.74383141
74MAP3K20.72397753
75TBK10.71609034
76CAMK10.71361484
77SGK20.71270021
78KIT0.71221515
79LCK0.70597319
80PAK30.69485343
81GRK10.69317880
82MELK0.68408546
83AKT30.66185406
84BTK0.65239621
85CHUK0.65186484
86PIM10.65167892
87IRAK20.63412072
88GSK3A0.62558766
89PDPK10.62109637
90EEF2K0.58239549
91PDGFRB0.57992245
92SYK0.56528944
93CDK40.56506884
94HCK0.56363255
95SGK2230.55788473
96SGK4940.55788473
97WNK30.55414438
98DAPK20.55369613
99RPS6KB10.54809377
100TYRO30.54561700
101STK40.53962982
102BMPR20.53918320
103TAOK10.53898141
104RET0.53563749
105MARK20.52621430
106GRK60.52610440
107SGK10.52309049
108NUAK10.52288799
109MTOR0.51336962
110RIPK10.50749681
111PRKD30.50507852
112BMPR1B0.49444429
113MAPK70.48768951
114PIK3CA0.48612085
115MAP2K20.48466911
116MAP3K40.46781345
117CDK120.46429276
118MST1R0.45313171
119NEK60.44999475
120MAP3K10.44102017
121PRKCQ0.43429986
122MAP3K70.43279152
123SIK30.43148593
124LYN0.43021762
125MKNK20.42605307
126MAP2K30.42374400
127PRKD20.41329079
128INSR0.41160684
129BRD40.40806999
130TNK20.39736263
131EPHB10.37961797
132EIF2AK20.37226743
133* PRKACG0.37086604
134IKBKB0.37069007
135MAP3K60.35555898
136MAP3K130.34646178
137STK30.31286419
138MAPK120.31065705
139MAPK40.30378533
140ERBB40.29791421

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.31162863
2Nitrogen metabolism_Homo sapiens_hsa009103.04933009
3Propanoate metabolism_Homo sapiens_hsa006402.94580206
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.91311137
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.90099735
6Fatty acid degradation_Homo sapiens_hsa000712.86939129
7PPAR signaling pathway_Homo sapiens_hsa033202.84403729
8Staphylococcus aureus infection_Homo sapiens_hsa051502.83505711
9Complement and coagulation cascades_Homo sapiens_hsa046102.52152770
10Tryptophan metabolism_Homo sapiens_hsa003802.50344242
11Fatty acid metabolism_Homo sapiens_hsa012122.41779909
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.20943528
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06948847
14Arginine biosynthesis_Homo sapiens_hsa002201.99206929
15Peroxisome_Homo sapiens_hsa041461.87531593
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85529140
17ABC transporters_Homo sapiens_hsa020101.80466361
18Fatty acid biosynthesis_Homo sapiens_hsa000611.80224065
19Butanoate metabolism_Homo sapiens_hsa006501.79533524
20beta-Alanine metabolism_Homo sapiens_hsa004101.78704247
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65445985
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.57238759
23Dorso-ventral axis formation_Homo sapiens_hsa043201.52947768
24Sulfur metabolism_Homo sapiens_hsa009201.52668130
25Selenocompound metabolism_Homo sapiens_hsa004501.50486883
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48386526
27Caffeine metabolism_Homo sapiens_hsa002321.47639487
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46720629
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44912119
30Glycerolipid metabolism_Homo sapiens_hsa005611.44054113
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42679063
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42513772
33Fat digestion and absorption_Homo sapiens_hsa049751.40942920
34Pyruvate metabolism_Homo sapiens_hsa006201.38778720
35* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.34603401
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32398890
37Phenylalanine metabolism_Homo sapiens_hsa003601.32268795
38Lysine degradation_Homo sapiens_hsa003101.31801187
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30761688
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.26530723
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22278313
42Linoleic acid metabolism_Homo sapiens_hsa005911.21865932
43Graft-versus-host disease_Homo sapiens_hsa053321.21597183
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.18973133
45Histidine metabolism_Homo sapiens_hsa003401.16794208
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16527226
47Chemokine signaling pathway_Homo sapiens_hsa040621.15475708
48Insulin resistance_Homo sapiens_hsa049311.15279103
49Tyrosine metabolism_Homo sapiens_hsa003501.12647820
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.11708558
51Non-small cell lung cancer_Homo sapiens_hsa052231.11339946
52Starch and sucrose metabolism_Homo sapiens_hsa005001.11183502
53Circadian rhythm_Homo sapiens_hsa047101.09460486
54Inositol phosphate metabolism_Homo sapiens_hsa005621.09281345
55Adipocytokine signaling pathway_Homo sapiens_hsa049201.09035434
56Allograft rejection_Homo sapiens_hsa053301.00215387
57Chemical carcinogenesis_Homo sapiens_hsa052040.99919516
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99469861
59Retinol metabolism_Homo sapiens_hsa008300.98002070
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96357827
61Platelet activation_Homo sapiens_hsa046110.94084345
62Type II diabetes mellitus_Homo sapiens_hsa049300.90562465
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88040597
64AMPK signaling pathway_Homo sapiens_hsa041520.87415460
65Carbon metabolism_Homo sapiens_hsa012000.85816310
66Bile secretion_Homo sapiens_hsa049760.82467875
67Herpes simplex infection_Homo sapiens_hsa051680.82365101
68Fatty acid elongation_Homo sapiens_hsa000620.81712966
69TNF signaling pathway_Homo sapiens_hsa046680.81460395
70Tuberculosis_Homo sapiens_hsa051520.80739960
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78667293
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75043255
73Ether lipid metabolism_Homo sapiens_hsa005650.74400612
74Hepatitis C_Homo sapiens_hsa051600.73045430
75Prion diseases_Homo sapiens_hsa050200.69975274
76Other glycan degradation_Homo sapiens_hsa005110.69151480
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68160044
78Hepatitis B_Homo sapiens_hsa051610.67880966
79mTOR signaling pathway_Homo sapiens_hsa041500.66811348
80* Glucagon signaling pathway_Homo sapiens_hsa049220.64622855
81Primary immunodeficiency_Homo sapiens_hsa053400.64141687
82Influenza A_Homo sapiens_hsa051640.63905950
83Malaria_Homo sapiens_hsa051440.63143964
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63098394
85Osteoclast differentiation_Homo sapiens_hsa043800.60993715
86Regulation of autophagy_Homo sapiens_hsa041400.59995748
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59010110
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58709434
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58433353
90Vitamin B6 metabolism_Homo sapiens_hsa007500.57735846
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57448480
92Folate biosynthesis_Homo sapiens_hsa007900.56024268
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54846852
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54644747
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53816741
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.51907736
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51542771
98Choline metabolism in cancer_Homo sapiens_hsa052310.51255141
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50067333
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.48665755
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48592238
102Lysosome_Homo sapiens_hsa041420.47925291
103* Insulin signaling pathway_Homo sapiens_hsa049100.47830176
104Endometrial cancer_Homo sapiens_hsa052130.46848631
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.45961569
106* Renin secretion_Homo sapiens_hsa049240.45533904
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44142634
108Legionellosis_Homo sapiens_hsa051340.43105600
109T cell receptor signaling pathway_Homo sapiens_hsa046600.42956423
110Colorectal cancer_Homo sapiens_hsa052100.42283789
111Measles_Homo sapiens_hsa051620.42099906
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41528795
113VEGF signaling pathway_Homo sapiens_hsa043700.41169271
114Phototransduction_Homo sapiens_hsa047440.41112528
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.40175671
116Antigen processing and presentation_Homo sapiens_hsa046120.39537846
117Vitamin digestion and absorption_Homo sapiens_hsa049770.37675826
118B cell receptor signaling pathway_Homo sapiens_hsa046620.36809110
119Biosynthesis of amino acids_Homo sapiens_hsa012300.34772666
120Acute myeloid leukemia_Homo sapiens_hsa052210.34311773
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33919057
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.33270681
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.33256852
124Pentose phosphate pathway_Homo sapiens_hsa000300.32882790
125Autoimmune thyroid disease_Homo sapiens_hsa053200.29816561
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.29320224
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27613033
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25644501
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25312051
130Prolactin signaling pathway_Homo sapiens_hsa049170.25240653
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24138484
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23801383
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23789412
134Toxoplasmosis_Homo sapiens_hsa051450.23274559
135Hematopoietic cell lineage_Homo sapiens_hsa046400.22511186
136Type I diabetes mellitus_Homo sapiens_hsa049400.21424261
137Leishmaniasis_Homo sapiens_hsa051400.20834332
138FoxO signaling pathway_Homo sapiens_hsa040680.20111512
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17566811
140Pertussis_Homo sapiens_hsa051330.16648044

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