Rank | Gene Set | Z-score |
---|---|---|
1 | positive regulation of gamma-delta T cell activation (GO:0046645) | 6.03857053 |
2 | regulation of gamma-delta T cell differentiation (GO:0045586) | 5.51929330 |
3 | negative T cell selection (GO:0043383) | 5.24662738 |
4 | L-phenylalanine catabolic process (GO:0006559) | 5.10934538 |
5 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 5.10934538 |
6 | valine metabolic process (GO:0006573) | 5.08866761 |
7 | regulation of gamma-delta T cell activation (GO:0046643) | 5.01123576 |
8 | negative thymic T cell selection (GO:0045060) | 4.96383352 |
9 | low-density lipoprotein particle clearance (GO:0034383) | 4.92273997 |
10 | regulation of sequestering of triglyceride (GO:0010889) | 4.91636225 |
11 | positive regulation of fatty acid beta-oxidation (GO:0032000) | 4.80442054 |
12 | complement activation, alternative pathway (GO:0006957) | 4.75285105 |
13 | alpha-linolenic acid metabolic process (GO:0036109) | 4.74608767 |
14 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 4.69888330 |
15 | L-phenylalanine metabolic process (GO:0006558) | 4.69888330 |
16 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.52313040 |
17 | positive regulation of granulocyte differentiation (GO:0030854) | 4.51952003 |
18 | response to interleukin-15 (GO:0070672) | 4.50796115 |
19 | aromatic amino acid family catabolic process (GO:0009074) | 4.41288064 |
20 | activated T cell proliferation (GO:0050798) | 4.39576793 |
21 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 4.39336006 |
22 | urea metabolic process (GO:0019627) | 4.38046944 |
23 | urea cycle (GO:0000050) | 4.38046944 |
24 | triglyceride catabolic process (GO:0019433) | 4.37025362 |
25 | positive T cell selection (GO:0043368) | 4.34331867 |
26 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 4.34054333 |
27 | negative regulation of macrophage derived foam cell differentiation (GO:0010745) | 4.33353953 |
28 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.26009215 |
29 | neutral lipid catabolic process (GO:0046461) | 4.23579075 |
30 | acylglycerol catabolic process (GO:0046464) | 4.23579075 |
31 | biotin metabolic process (GO:0006768) | 4.22587301 |
32 | regulation of triglyceride catabolic process (GO:0010896) | 4.18197764 |
33 | positive regulation of fatty acid oxidation (GO:0046321) | 4.11926464 |
34 | cellular response to interleukin-15 (GO:0071350) | 4.10758727 |
35 | acylglycerol homeostasis (GO:0055090) | 4.10044285 |
36 | triglyceride homeostasis (GO:0070328) | 4.10044285 |
37 | fatty acid beta-oxidation (GO:0006635) | 4.07514525 |
38 | plasma lipoprotein particle clearance (GO:0034381) | 4.01485939 |
39 | nitrogen cycle metabolic process (GO:0071941) | 3.96392092 |
40 | sulfur amino acid catabolic process (GO:0000098) | 3.95728070 |
41 | fatty acid transmembrane transport (GO:1902001) | 3.94912217 |
42 | interferon-gamma production (GO:0032609) | 3.94435571 |
43 | positive regulation of lipid catabolic process (GO:0050996) | 3.91318156 |
44 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.87910972 |
45 | peptidyl-glutamic acid carboxylation (GO:0017187) | 3.84648234 |
46 | protein carboxylation (GO:0018214) | 3.84648234 |
47 | negative regulation of T cell mediated immunity (GO:0002710) | 3.83802828 |
48 | fatty acid oxidation (GO:0019395) | 3.83100198 |
49 | regulation of fatty acid beta-oxidation (GO:0031998) | 3.82846647 |
50 | phospholipid homeostasis (GO:0055091) | 3.77132337 |
51 | lipid oxidation (GO:0034440) | 3.74669418 |
52 | indole-containing compound catabolic process (GO:0042436) | 3.74341640 |
53 | indolalkylamine catabolic process (GO:0046218) | 3.74341640 |
54 | tryptophan catabolic process (GO:0006569) | 3.74341640 |
55 | fatty acid catabolic process (GO:0009062) | 3.74294754 |
56 | T cell migration (GO:0072678) | 3.70722047 |
57 | tryptophan metabolic process (GO:0006568) | 3.70208107 |
58 | regulation of protein activation cascade (GO:2000257) | 3.68580619 |
59 | negative regulation of execution phase of apoptosis (GO:1900118) | 3.67559899 |
60 | regulation of cholesterol storage (GO:0010885) | 3.65723488 |
61 | T cell selection (GO:0045058) | 3.64882411 |
62 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.59485577 |
63 | regulation of regulatory T cell differentiation (GO:0045589) | 3.57589216 |
64 | phospholipid efflux (GO:0033700) | 3.57062641 |
65 | positive thymic T cell selection (GO:0045059) | 3.56871187 |
66 | tolerance induction (GO:0002507) | 3.56435840 |
67 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 3.54388375 |
68 | negative regulation of lipase activity (GO:0060192) | 3.54175109 |
69 | bile acid biosynthetic process (GO:0006699) | 3.53021669 |
70 | regulation of complement activation (GO:0030449) | 3.52966839 |
71 | tyrosine metabolic process (GO:0006570) | 3.52230558 |
72 | regulation of granulocyte differentiation (GO:0030852) | 3.51421064 |
73 | bile acid metabolic process (GO:0008206) | 3.50394903 |
74 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.45280827 |
75 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.44143154 |
76 | lipid storage (GO:0019915) | 3.43916917 |
77 | cytolysis (GO:0019835) | 3.43658180 |
78 | brown fat cell differentiation (GO:0050873) | 3.42442833 |
79 | carnitine shuttle (GO:0006853) | 3.41951601 |
80 | cellular extravasation (GO:0045123) | 3.41492060 |
81 | homocysteine metabolic process (GO:0050667) | 3.40260118 |
82 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.39219018 |
83 | fatty acid homeostasis (GO:0055089) | 3.36621796 |
84 | positive regulation of glycolytic process (GO:0045821) | 3.35875517 |
85 | monocarboxylic acid catabolic process (GO:0072329) | 3.35549654 |
86 | kynurenine metabolic process (GO:0070189) | 3.35072433 |
87 | acetyl-CoA metabolic process (GO:0006084) | 3.34468729 |
88 | cellular response to ethanol (GO:0071361) | 3.34453656 |
89 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.31845543 |
90 | amino-acid betaine metabolic process (GO:0006577) | 3.31254893 |
91 | branched-chain amino acid metabolic process (GO:0009081) | 3.29881726 |
92 | reverse cholesterol transport (GO:0043691) | 3.27020265 |
93 | bile acid and bile salt transport (GO:0015721) | 3.26578173 |
94 | thymic T cell selection (GO:0045061) | 3.25849650 |
95 | cysteine metabolic process (GO:0006534) | 3.24766234 |
96 | high-density lipoprotein particle remodeling (GO:0034375) | 3.24192694 |
97 | lysine metabolic process (GO:0006553) | 3.21853752 |
98 | lysine catabolic process (GO:0006554) | 3.21853752 |
99 | establishment of protein localization to Golgi (GO:0072600) | 3.19856297 |
100 | negative regulation of granulocyte differentiation (GO:0030853) | 3.17940098 |
101 | positive regulation of fatty acid metabolic process (GO:0045923) | 3.17805288 |
102 | negative regulation of fibrinolysis (GO:0051918) | 3.16528973 |
103 | regulation of fatty acid oxidation (GO:0046320) | 3.15753575 |
104 | histone H3-K4 trimethylation (GO:0080182) | 3.14390135 |
105 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.13188005 |
106 | tricarboxylic acid metabolic process (GO:0072350) | 3.12195113 |
107 | aromatic amino acid family metabolic process (GO:0009072) | 3.11916527 |
108 | negative regulation of lipid storage (GO:0010888) | 3.11019268 |
109 | regulation of fibrinolysis (GO:0051917) | 3.10948396 |
110 | complement activation (GO:0006956) | 3.10906775 |
111 | glycerolipid catabolic process (GO:0046503) | 3.10733530 |
112 | glyoxylate metabolic process (GO:0046487) | 3.09896695 |
113 | 2-oxoglutarate metabolic process (GO:0006103) | 3.09648102 |
114 | triglyceride metabolic process (GO:0006641) | 3.04742265 |
115 | plasma lipoprotein particle assembly (GO:0034377) | 3.04580143 |
116 | serine family amino acid catabolic process (GO:0009071) | 3.03244058 |
117 | positive regulation of cholesterol transport (GO:0032376) | 3.02801053 |
118 | positive regulation of sterol transport (GO:0032373) | 3.02801053 |
119 | branched-chain amino acid catabolic process (GO:0009083) | 3.02678664 |
120 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.01353371 |
121 | negative regulation of cell killing (GO:0031342) | 3.01353371 |
122 | regulation of triglyceride metabolic process (GO:0090207) | 3.01333310 |
123 | white fat cell differentiation (GO:0050872) | 3.00336742 |
124 | short-chain fatty acid metabolic process (GO:0046459) | 3.00299672 |
125 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.99614793 |
126 | protein targeting to Golgi (GO:0000042) | 2.98700610 |
127 | complement activation, classical pathway (GO:0006958) | 2.97557412 |
128 | plasma lipoprotein particle remodeling (GO:0034369) | 2.96444353 |
129 | protein-lipid complex remodeling (GO:0034368) | 2.96444353 |
130 | macromolecular complex remodeling (GO:0034367) | 2.96444353 |
131 | negative regulation of protein autophosphorylation (GO:0031953) | 2.95505782 |
132 | regulation of macrophage derived foam cell differentiation (GO:0010743) | 2.94481403 |
133 | acylglycerol metabolic process (GO:0006639) | 2.94137042 |
134 | histone H3-K36 demethylation (GO:0070544) | 2.93976276 |
135 | indolalkylamine metabolic process (GO:0006586) | 2.93363119 |
136 | alpha-amino acid catabolic process (GO:1901606) | 2.93112162 |
137 | alpha-beta T cell differentiation (GO:0046632) | 2.92583791 |
138 | organic acid catabolic process (GO:0016054) | 2.89994111 |
139 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.88525316 |
140 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 2.86115034 |
141 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 2.85592585 |
142 | diacylglycerol metabolic process (GO:0046339) | 2.85123952 |
143 | regulation of isotype switching to IgG isotypes (GO:0048302) | 2.77317505 |
144 | hepatocyte apoptotic process (GO:0097284) | 2.76561207 |
145 | production of molecular mediator involved in inflammatory response (GO:0002532) | 2.75636905 |
146 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 2.73875319 |
147 | B cell receptor signaling pathway (GO:0050853) | 2.72291039 |
148 | regulation of T cell tolerance induction (GO:0002664) | 2.71001881 |
149 | positive regulation of tolerance induction (GO:0002645) | 2.69803770 |
150 | negative regulation of leukocyte mediated immunity (GO:0002704) | 2.69746036 |
151 | dendritic cell migration (GO:0036336) | 2.67312155 |
152 | regulation of T cell mediated cytotoxicity (GO:0001914) | 2.66553408 |
153 | regulation of B cell differentiation (GO:0045577) | 2.66095335 |
154 | alpha-beta T cell activation (GO:0046631) | 2.65979950 |
155 | antigen processing and presentation via MHC class Ib (GO:0002475) | 2.64794902 |
156 | mast cell activation (GO:0045576) | 2.61534750 |
157 | leukocyte aggregation (GO:0070486) | 2.60823350 |
158 | negative regulation of adaptive immune response (GO:0002820) | 2.60012383 |
159 | T cell differentiation (GO:0030217) | 2.59795184 |
160 | monoubiquitinated protein deubiquitination (GO:0035520) | 2.59198415 |
161 | T cell receptor signaling pathway (GO:0050852) | 2.58530809 |
162 | protein K11-linked deubiquitination (GO:0035871) | 2.57393680 |
163 | negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642) | 2.55976343 |
164 | cellular ketone body metabolic process (GO:0046950) | 2.54608833 |
165 | positive regulation of B cell differentiation (GO:0045579) | 2.52934957 |
166 | antigen receptor-mediated signaling pathway (GO:0050851) | 2.52524122 |
167 | neural tube formation (GO:0001841) | 2.52330258 |
168 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 2.52044394 |
169 | regulation of natural killer cell mediated immunity (GO:0002715) | 2.52044394 |
170 | regulation of tolerance induction (GO:0002643) | 2.51855998 |
171 | detection of molecule of bacterial origin (GO:0032490) | 2.47697564 |
172 | negative regulation of phagocytosis (GO:0050765) | 2.47186117 |
173 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 2.45258841 |
174 | microglial cell activation (GO:0001774) | 2.44384424 |
175 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 2.41877407 |
176 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.39739367 |
177 | Peyers patch development (GO:0048541) | 2.38805481 |
178 | mucosal-associated lymphoid tissue development (GO:0048537) | 2.38805481 |
179 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.37557635 |
180 | T cell proliferation (GO:0042098) | 2.37160462 |
181 | negative regulation of immunoglobulin mediated immune response (GO:0002890) | 2.36586069 |
182 | negative regulation of B cell mediated immunity (GO:0002713) | 2.36586069 |
183 | myeloid leukocyte mediated immunity (GO:0002444) | 2.36140501 |
184 | T-helper cell differentiation (GO:0042093) | 2.35242532 |
185 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 2.35242532 |
186 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 2.33596654 |
187 | ketone body metabolic process (GO:1902224) | 2.33007701 |
188 | histone mRNA catabolic process (GO:0071044) | 2.32716410 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 6.89729341 |
2 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 6.59105565 |
3 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 5.51620951 |
4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 4.81954405 |
5 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 4.79171569 |
6 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 4.28031665 |
7 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 3.76151292 |
8 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 3.25594430 |
9 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.14914659 |
10 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 3.13084166 |
11 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 3.05974656 |
12 | GATA1_22025678_ChIP-Seq_K562_Human | 3.05341059 |
13 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.02459918 |
14 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.97183202 |
15 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.70270607 |
16 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.47994455 |
17 | * STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.45972175 |
18 | CLOCK_20551151_ChIP-Seq_293T_Human | 2.34776298 |
19 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.06950842 |
20 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.00691408 |
21 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.96057730 |
22 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.92079020 |
23 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.89635268 |
24 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.87154940 |
25 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.81967917 |
26 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.77336504 |
27 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.72078752 |
28 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.65586210 |
29 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.64332016 |
30 | * NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.64309083 |
31 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.63084627 |
32 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.57505488 |
33 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.50353119 |
34 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.48426520 |
35 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.47823378 |
36 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.46202226 |
37 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.45307612 |
38 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.44498740 |
39 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.42837630 |
40 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.40324544 |
41 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.37483174 |
42 | * RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.33752205 |
43 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.31891193 |
44 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.31165192 |
45 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.30864037 |
46 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.26948504 |
47 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.25499676 |
48 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.24726330 |
49 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.24132603 |
50 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.23504933 |
51 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.22642486 |
52 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.19236985 |
53 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.17800314 |
54 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.17213591 |
55 | MYB_26560356_Chip-Seq_TH2_Human | 1.17149402 |
56 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.17128697 |
57 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.16806146 |
58 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.16040066 |
59 | * PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 1.14580128 |
60 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 1.14469568 |
61 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 1.14309059 |
62 | MYB_26560356_Chip-Seq_TH1_Human | 1.12646761 |
63 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.12312555 |
64 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.10400652 |
65 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.10157848 |
66 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.09050418 |
67 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.08660655 |
68 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.08656965 |
69 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.07631081 |
70 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.06724682 |
71 | * SMRT_27268052_Chip-Seq_Bcells_Human | 1.06053054 |
72 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.04802197 |
73 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.02244017 |
74 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.01537859 |
75 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.01474959 |
76 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.01437445 |
77 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.00874213 |
78 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.00127955 |
79 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.00060786 |
80 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.99192087 |
81 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.97363617 |
82 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.97173157 |
83 | * FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.96422343 |
84 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 0.96324426 |
85 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.95504433 |
86 | P300_19829295_ChIP-Seq_ESCs_Human | 0.95132598 |
87 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.94589059 |
88 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.94264487 |
89 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.93583033 |
90 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.93021858 |
91 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.92991058 |
92 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.92545569 |
93 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.91875022 |
94 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.91871008 |
95 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.91782664 |
96 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.91653465 |
97 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.91099832 |
98 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.89459162 |
99 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.89436605 |
100 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.89436605 |
101 | GATA3_26560356_Chip-Seq_TH2_Human | 0.89246410 |
102 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.89140147 |
103 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.88471984 |
104 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.88403751 |
105 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.87987848 |
106 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87594778 |
107 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.87219021 |
108 | GATA2_19941826_ChIP-Seq_K562_Human | 0.87142620 |
109 | VDR_22108803_ChIP-Seq_LS180_Human | 0.87058092 |
110 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.86880461 |
111 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.86288372 |
112 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.86220205 |
113 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.84708795 |
114 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.84708795 |
115 | GATA1_19941826_ChIP-Seq_K562_Human | 0.84553951 |
116 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 0.83449438 |
117 | SPI1_23127762_ChIP-Seq_K562_Human | 0.82702042 |
118 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.81684345 |
119 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.81546686 |
120 | * AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.79558323 |
121 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 0.78082362 |
122 | MAF_26560356_Chip-Seq_TH1_Human | 0.77805494 |
123 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.76816400 |
124 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.75250786 |
125 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.75140763 |
126 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.73814201 |
127 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.73334390 |
128 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.73235676 |
129 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.72394835 |
130 | * UTX_26944678_Chip-Seq_JUKART_Human | 0.71974313 |
131 | MYC_22102868_ChIP-Seq_BL_Human | 0.71447975 |
132 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.70971854 |
133 | * FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.70403294 |
134 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.70099295 |
135 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.68834680 |
136 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.65973712 |
137 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.65486758 |
138 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.65144874 |
139 | GATA3_26560356_Chip-Seq_TH1_Human | 0.64908554 |
140 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.63886529 |
141 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.63711226 |
142 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.63406071 |
143 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.63369574 |
144 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.62953419 |
145 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.62627882 |
146 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.62591412 |
147 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.62559129 |
148 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.61998792 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 5.20253888 |
2 | MP0005670_abnormal_white_adipose | 5.06303981 |
3 | MP0005365_abnormal_bile_salt | 4.69603570 |
4 | MP0005360_urolithiasis | 4.15312469 |
5 | MP0005085_abnormal_gallbladder_physiolo | 3.88013735 |
6 | MP0003252_abnormal_bile_duct | 3.36702762 |
7 | MP0003191_abnormal_cellular_cholesterol | 3.26748890 |
8 | MP0010329_abnormal_lipoprotein_level | 3.23374579 |
9 | MP0005666_abnormal_adipose_tissue | 3.03247150 |
10 | MP0002009_preneoplasia | 2.45769593 |
11 | MP0004130_abnormal_muscle_cell | 2.43276160 |
12 | MP0008875_abnormal_xenobiotic_pharmacok | 2.43238466 |
13 | MP0004185_abnormal_adipocyte_glucose | 2.42772268 |
14 | MP0000569_abnormal_digit_pigmentation | 2.39012889 |
15 | MP0008057_abnormal_DNA_replication | 2.33355649 |
16 | MP0003787_abnormal_imprinting | 2.31387724 |
17 | MP0000609_abnormal_liver_physiology | 2.24652583 |
18 | MP0005375_adipose_tissue_phenotype | 2.16232681 |
19 | * MP0002118_abnormal_lipid_homeostasis | 2.14777610 |
20 | MP0005075_abnormal_melanosome_morpholog | 2.13657176 |
21 | MP0000013_abnormal_adipose_tissue | 2.09930231 |
22 | MP0002971_abnormal_brown_adipose | 1.96351108 |
23 | MP0004381_abnormal_hair_follicle | 1.91590380 |
24 | MP0002138_abnormal_hepatobiliary_system | 1.90177603 |
25 | MP0008877_abnormal_DNA_methylation | 1.88531974 |
26 | MP0009840_abnormal_foam_cell | 1.83860931 |
27 | * MP0005334_abnormal_fat_pad | 1.79830487 |
28 | MP0003300_gastrointestinal_ulcer | 1.79612353 |
29 | MP0002876_abnormal_thyroid_physiology | 1.70376455 |
30 | MP0001666_abnormal_nutrient_absorption | 1.68854586 |
31 | MP0002877_abnormal_melanocyte_morpholog | 1.68248223 |
32 | * MP0002078_abnormal_glucose_homeostasis | 1.64397303 |
33 | MP0003195_calcinosis | 1.64240623 |
34 | MP0000703_abnormal_thymus_morphology | 1.63507470 |
35 | MP0005332_abnormal_amino_acid | 1.60614977 |
36 | MP0005535_abnormal_body_temperature | 1.59612788 |
37 | MP0003868_abnormal_feces_composition | 1.55305990 |
38 | MP0000003_abnormal_adipose_tissue | 1.52636101 |
39 | MP0002405_respiratory_system_inflammati | 1.52473643 |
40 | MP0003724_increased_susceptibility_to | 1.51387180 |
41 | MP0001764_abnormal_homeostasis | 1.49694236 |
42 | MP0002398_abnormal_bone_marrow | 1.46176918 |
43 | MP0000689_abnormal_spleen_morphology | 1.44833272 |
44 | MP0002163_abnormal_gland_morphology | 1.43908982 |
45 | MP0002837_dystrophic_cardiac_calcinosis | 1.43121592 |
46 | MP0002396_abnormal_hematopoietic_system | 1.42165366 |
47 | MP0005671_abnormal_response_to | 1.41621188 |
48 | * MP0002693_abnormal_pancreas_physiology | 1.40808666 |
49 | MP0003866_abnormal_defecation | 1.39796240 |
50 | * MP0009115_abnormal_fat_cell | 1.39411677 |
51 | MP0000716_abnormal_immune_system | 1.38424627 |
52 | MP0006082_CNS_inflammation | 1.37939655 |
53 | MP0002928_abnormal_bile_duct | 1.37778318 |
54 | MP0002166_altered_tumor_susceptibility | 1.36594508 |
55 | MP0001944_abnormal_pancreas_morphology | 1.34945454 |
56 | MP0001661_extended_life_span | 1.33872923 |
57 | MP0002970_abnormal_white_adipose | 1.33674696 |
58 | MP0009643_abnormal_urine_homeostasis | 1.33151113 |
59 | MP0009333_abnormal_splenocyte_physiolog | 1.31679378 |
60 | MP0005319_abnormal_enzyme/_coenzyme | 1.28956268 |
61 | MP0000015_abnormal_ear_pigmentation | 1.28684579 |
62 | MP0001835_abnormal_antigen_presentation | 1.27624253 |
63 | MP0002722_abnormal_immune_system | 1.25728110 |
64 | MP0005174_abnormal_tail_pigmentation | 1.24527863 |
65 | MP0003959_abnormal_lean_body | 1.24384784 |
66 | MP0005448_abnormal_energy_balance | 1.23013793 |
67 | MP0000372_irregular_coat_pigmentation | 1.22517475 |
68 | MP0003436_decreased_susceptibility_to | 1.21627356 |
69 | MP0002638_abnormal_pupillary_reflex | 1.19641324 |
70 | MP0005310_abnormal_salivary_gland | 1.17743652 |
71 | MP0005220_abnormal_exocrine_pancreas | 1.17456256 |
72 | MP0005464_abnormal_platelet_physiology | 1.15969752 |
73 | MP0003690_abnormal_glial_cell | 1.14826208 |
74 | MP0003045_fibrosis | 1.13254516 |
75 | MP0005058_abnormal_lysosome_morphology | 1.13237647 |
76 | MP0003828_pulmonary_edema | 1.12800278 |
77 | MP0004019_abnormal_vitamin_homeostasis | 1.12098973 |
78 | MP0003183_abnormal_peptide_metabolism | 1.11373062 |
79 | MP0008469_abnormal_protein_level | 1.10739499 |
80 | MP0005083_abnormal_biliary_tract | 1.07802184 |
81 | MP0009763_increased_sensitivity_to | 1.07294418 |
82 | MP0005379_endocrine/exocrine_gland_phen | 1.06435240 |
83 | MP0000598_abnormal_liver_morphology | 1.05498525 |
84 | MP0009780_abnormal_chondrocyte_physiolo | 1.04425012 |
85 | MP0003763_abnormal_thymus_physiology | 1.03706836 |
86 | * MP0005584_abnormal_enzyme/coenzyme_acti | 1.01687014 |
87 | MP0002909_abnormal_adrenal_gland | 1.01049573 |
88 | MP0005645_abnormal_hypothalamus_physiol | 1.00633408 |
89 | MP0001800_abnormal_humoral_immune | 1.00322975 |
90 | MP0003303_peritoneal_inflammation | 0.99465174 |
91 | MP0010155_abnormal_intestine_physiology | 0.98921371 |
92 | MP0002429_abnormal_blood_cell | 0.98214766 |
93 | MP0008961_abnormal_basal_metabolism | 0.97868611 |
94 | MP0003806_abnormal_nucleotide_metabolis | 0.97277835 |
95 | MP0002148_abnormal_hypersensitivity_rea | 0.97238927 |
96 | MP0000371_diluted_coat_color | 0.97199619 |
97 | MP0002254_reproductive_system_inflammat | 0.96999983 |
98 | MP0004883_abnormal_blood_vessel | 0.96585587 |
99 | MP0001986_abnormal_taste_sensitivity | 0.94962028 |
100 | MP0001873_stomach_inflammation | 0.94852593 |
101 | MP0001790_abnormal_immune_system | 0.94812928 |
102 | MP0005387_immune_system_phenotype | 0.94812928 |
103 | MP0002933_joint_inflammation | 0.93416396 |
104 | MP0003646_muscle_fatigue | 0.90827583 |
105 | MP0002419_abnormal_innate_immunity | 0.90706252 |
106 | MP0001851_eye_inflammation | 0.90000192 |
107 | * MP0009642_abnormal_blood_homeostasis | 0.89953031 |
108 | MP0005647_abnormal_sex_gland | 0.89934070 |
109 | * MP0003953_abnormal_hormone_level | 0.89264936 |
110 | MP0003172_abnormal_lysosome_physiology | 0.89124204 |
111 | MP0001756_abnormal_urination | 0.88993937 |
112 | MP0001845_abnormal_inflammatory_respons | 0.88294896 |
113 | MP0002006_tumorigenesis | 0.85240601 |
114 | MP0005000_abnormal_immune_tolerance | 0.84920336 |
115 | MP0008438_abnormal_cutaneous_collagen | 0.83508185 |
116 | MP0000685_abnormal_immune_system | 0.83104147 |
117 | MP0009697_abnormal_copulation | 0.82768208 |
118 | * MP0005452_abnormal_adipose_tissue | 0.82113264 |
119 | MP0002168_other_aberrant_phenotype | 0.81781539 |
120 | MP0002723_abnormal_immune_serum | 0.81251843 |
121 | MP0002998_abnormal_bone_remodeling | 0.76605081 |
122 | MP0001533_abnormal_skeleton_physiology | 0.76033138 |
123 | MP0005408_hypopigmentation | 0.73792236 |
124 | MP0002452_abnormal_antigen_presenting | 0.73558519 |
125 | MP0003186_abnormal_redox_activity | 0.73319418 |
126 | MP0001501_abnormal_sleep_pattern | 0.73065098 |
127 | MP0009764_decreased_sensitivity_to | 0.71659946 |
128 | MP0005025_abnormal_response_to | 0.71504381 |
129 | MP0001881_abnormal_mammary_gland | 0.70753625 |
130 | MP0003705_abnormal_hypodermis_morpholog | 0.70063790 |
131 | MP0009672_abnormal_birth_weight | 0.69799643 |
132 | MP0002420_abnormal_adaptive_immunity | 0.67694091 |
133 | MP0001819_abnormal_immune_cell | 0.67404035 |
134 | MP0001853_heart_inflammation | 0.66411750 |
135 | MP0009785_altered_susceptibility_to | 0.65785948 |
136 | MP0002136_abnormal_kidney_physiology | 0.65688991 |
137 | MP0009765_abnormal_xenobiotic_induced | 0.61173949 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Complement deficiency (HP:0004431) | 6.00146495 |
2 | Hypoglycemic coma (HP:0001325) | 5.19953106 |
3 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 4.55098965 |
4 | Stomatitis (HP:0010280) | 4.47730746 |
5 | Systemic lupus erythematosus (HP:0002725) | 4.33489016 |
6 | Xanthomatosis (HP:0000991) | 4.31458911 |
7 | Deep venous thrombosis (HP:0002625) | 4.29753402 |
8 | Abnormality of complement system (HP:0005339) | 4.28841614 |
9 | Prolonged partial thromboplastin time (HP:0003645) | 4.26307720 |
10 | Hypoglycemic seizures (HP:0002173) | 4.25889342 |
11 | Intrahepatic cholestasis (HP:0001406) | 4.25692216 |
12 | Ketosis (HP:0001946) | 3.95089392 |
13 | Hyperglycinuria (HP:0003108) | 3.86640742 |
14 | Epidermoid cyst (HP:0200040) | 3.82912405 |
15 | Joint hemorrhage (HP:0005261) | 3.82232273 |
16 | Hyperinsulinemic hypoglycemia (HP:0000825) | 3.79120096 |
17 | Oligomenorrhea (HP:0000876) | 3.74580366 |
18 | Ketoacidosis (HP:0001993) | 3.74384011 |
19 | Hyperlipoproteinemia (HP:0010980) | 3.71186239 |
20 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 3.70681228 |
21 | Eczematoid dermatitis (HP:0000976) | 3.69172169 |
22 | Abnormality of the common coagulation pathway (HP:0010990) | 3.66361407 |
23 | Abnormality of the intrinsic pathway (HP:0010989) | 3.62919724 |
24 | Hypoalphalipoproteinemia (HP:0003233) | 3.59295507 |
25 | Myocardial infarction (HP:0001658) | 3.58299747 |
26 | Insulin-resistant diabetes mellitus (HP:0000831) | 3.48671890 |
27 | Severe combined immunodeficiency (HP:0004430) | 3.48150523 |
28 | Thyroiditis (HP:0100646) | 3.47901343 |
29 | Glomerulonephritis (HP:0000099) | 3.47541557 |
30 | Optic neuritis (HP:0100653) | 3.46548366 |
31 | Retrobulbar optic neuritis (HP:0100654) | 3.46548366 |
32 | Myositis (HP:0100614) | 3.38027296 |
33 | Conjugated hyperbilirubinemia (HP:0002908) | 3.32388045 |
34 | Recurrent fungal infections (HP:0002841) | 3.30881059 |
35 | Abnormality of glycine metabolism (HP:0010895) | 3.30185027 |
36 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.30185027 |
37 | Hyperglycemia (HP:0003074) | 3.30039337 |
38 | Recurrent bacterial skin infections (HP:0005406) | 3.29508324 |
39 | Hypobetalipoproteinemia (HP:0003563) | 3.28067157 |
40 | Hypolipoproteinemia (HP:0010981) | 3.27476856 |
41 | Symptomatic seizures (HP:0011145) | 3.26231225 |
42 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 3.26174530 |
43 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.21666081 |
44 | Hyperammonemia (HP:0001987) | 3.15473494 |
45 | Hyperglycinemia (HP:0002154) | 3.09604126 |
46 | Gastrointestinal infarctions (HP:0005244) | 3.08793870 |
47 | Orchitis (HP:0100796) | 3.08409121 |
48 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.04968068 |
49 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.01508693 |
50 | Recurrent abscess formation (HP:0002722) | 3.00644874 |
51 | Hematochezia (HP:0002573) | 2.94672295 |
52 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 2.87226271 |
53 | Hypertriglyceridemia (HP:0002155) | 2.86501409 |
54 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.81623216 |
55 | Recurrent cutaneous fungal infections (HP:0011370) | 2.81623216 |
56 | Spontaneous hematomas (HP:0007420) | 2.76714868 |
57 | Limb hypertonia (HP:0002509) | 2.76674797 |
58 | Skin nodule (HP:0200036) | 2.74921831 |
59 | T lymphocytopenia (HP:0005403) | 2.72839158 |
60 | Insulin resistance (HP:0000855) | 2.67964189 |
61 | Hypercholesterolemia (HP:0003124) | 2.66134367 |
62 | Prolonged bleeding time (HP:0003010) | 2.65636563 |
63 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.63005729 |
64 | Increased CSF protein (HP:0002922) | 2.62177437 |
65 | Recurrent skin infections (HP:0001581) | 2.61703837 |
66 | Generalized aminoaciduria (HP:0002909) | 2.61564877 |
67 | Pancreatitis (HP:0001733) | 2.59321451 |
68 | Combined immunodeficiency (HP:0005387) | 2.59039220 |
69 | Abnormality of T cell number (HP:0011839) | 2.58835801 |
70 | Abnormality of eosinophils (HP:0001879) | 2.57163753 |
71 | Leukocytosis (HP:0001974) | 2.54770010 |
72 | Renal cortical cysts (HP:0000803) | 2.54730624 |
73 | Abnormality of endocrine pancreas physiology (HP:0012093) | 2.51903024 |
74 | Abnormality of the pancreatic islet cells (HP:0006476) | 2.51903024 |
75 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.47982200 |
76 | Hemorrhage of the eye (HP:0011885) | 2.47784497 |
77 | Keratoconjunctivitis (HP:0001096) | 2.46099534 |
78 | Keratoconjunctivitis sicca (HP:0001097) | 2.46030826 |
79 | Pustule (HP:0200039) | 2.45823614 |
80 | Retinal atrophy (HP:0001105) | 2.45117372 |
81 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.44784352 |
82 | Late onset (HP:0003584) | 2.44779263 |
83 | Fat malabsorption (HP:0002630) | 2.43948632 |
84 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.43313017 |
85 | Autoimmune hemolytic anemia (HP:0001890) | 2.41829424 |
86 | Encephalitis (HP:0002383) | 2.41735600 |
87 | Abnormality of proline metabolism (HP:0010907) | 2.41301615 |
88 | Hydroxyprolinuria (HP:0003080) | 2.41301615 |
89 | Panhypogammaglobulinemia (HP:0003139) | 2.40999206 |
90 | IgG deficiency (HP:0004315) | 2.40632432 |
91 | Abnormality of purine metabolism (HP:0004352) | 2.39593562 |
92 | Abnormality of T cell physiology (HP:0011840) | 2.38377979 |
93 | Mucopolysacchariduria (HP:0008155) | 2.37087720 |
94 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.37087720 |
95 | Vasculitis (HP:0002633) | 2.36958088 |
96 | Stomach cancer (HP:0012126) | 2.36130124 |
97 | Chronic diarrhea (HP:0002028) | 2.33935007 |
98 | Acanthosis nigricans (HP:0000956) | 2.32373504 |
99 | Hemoptysis (HP:0002105) | 2.29335429 |
100 | Dysostosis multiplex (HP:0000943) | 2.28573241 |
101 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.27446081 |
102 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.27446081 |
103 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.27446081 |
104 | Abnormality of the renal cortex (HP:0011035) | 2.25744864 |
105 | Hypochromic microcytic anemia (HP:0004840) | 2.24119622 |
106 | Nephritis (HP:0000123) | 2.23952156 |
107 | Hypoplasia of the thymus (HP:0000778) | 2.23727082 |
108 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.22364496 |
109 | Pulmonary embolism (HP:0002204) | 2.22352691 |
110 | Abnormality of macrophages (HP:0004311) | 2.20060748 |
111 | Inflammation of the large intestine (HP:0002037) | 2.19744070 |
112 | Abnormality of methionine metabolism (HP:0010901) | 2.19263464 |
113 | Gingival bleeding (HP:0000225) | 2.19260329 |
114 | Abnormality of nucleobase metabolism (HP:0010932) | 2.18650173 |
115 | Recurrent viral infections (HP:0004429) | 2.18332502 |
116 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.18077255 |
117 | Dicarboxylic aciduria (HP:0003215) | 2.18077255 |
118 | Lymphopenia (HP:0001888) | 2.17499751 |
119 | Gaze-evoked nystagmus (HP:0000640) | 2.15606174 |
120 | Fair hair (HP:0002286) | 2.14634746 |
121 | Congenital stationary night blindness (HP:0007642) | 2.14472369 |
122 | Joint swelling (HP:0001386) | 2.12556952 |
123 | Meningitis (HP:0001287) | 2.11332284 |
124 | Menorrhagia (HP:0000132) | 2.10621627 |
125 | Hyperventilation (HP:0002883) | 2.09627908 |
126 | Recurrent bronchitis (HP:0002837) | 2.08975727 |
127 | Eosinophilia (HP:0001880) | 2.07781205 |
128 | IgM deficiency (HP:0002850) | 2.05582293 |
129 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.04722094 |
130 | Pulmonary infiltrates (HP:0002113) | 2.03873192 |
131 | Gingivitis (HP:0000230) | 2.03529176 |
132 | Hepatocellular carcinoma (HP:0001402) | 2.01516796 |
133 | Genetic anticipation (HP:0003743) | 2.01076536 |
134 | Hyperbilirubinemia (HP:0002904) | 2.00173271 |
135 | Arterial thrombosis (HP:0004420) | 2.00119842 |
136 | Granulocytopenia (HP:0001913) | 1.99314338 |
137 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 1.98935398 |
138 | Abnormality of B cell number (HP:0010975) | 1.98169803 |
139 | Upper motor neuron abnormality (HP:0002127) | 1.97045558 |
140 | Decreased circulating renin level (HP:0003351) | 1.97031392 |
141 | Gastrointestinal inflammation (HP:0004386) | 1.95381777 |
142 | Abnormal platelet volume (HP:0011876) | 1.95323336 |
143 | Mitral stenosis (HP:0001718) | 1.94951883 |
144 | Episodic fever (HP:0001954) | 1.94580787 |
145 | Generalized hypopigmentation of hair (HP:0011358) | 1.94209230 |
146 | Cerebral aneurysm (HP:0004944) | 1.91008182 |
147 | Papilledema (HP:0001085) | 1.90982010 |
148 | Hypochromic anemia (HP:0001931) | 1.90311135 |
149 | Albinism (HP:0001022) | 1.89643003 |
150 | Epistaxis (HP:0000421) | 1.89267748 |
151 | Acute hepatic failure (HP:0006554) | 1.88954434 |
152 | Abnormality of serum amino acid levels (HP:0003112) | 1.88820003 |
153 | Metabolic acidosis (HP:0001942) | 1.88723600 |
154 | Myoglobinuria (HP:0002913) | 1.88530941 |
155 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 1.88492843 |
156 | Hyperkalemia (HP:0002153) | 1.87641763 |
157 | Increased mean platelet volume (HP:0011877) | 1.87041765 |
158 | Intestinal atresia (HP:0011100) | 1.86556501 |
159 | Mediastinal lymphadenopathy (HP:0100721) | 1.86532167 |
160 | Glucose intolerance (HP:0000833) | 1.86363245 |
161 | Sensorimotor neuropathy (HP:0007141) | 1.85411083 |
162 | Enlarged kidneys (HP:0000105) | 1.84185242 |
163 | Attenuation of retinal blood vessels (HP:0007843) | 1.83085083 |
164 | Abnormality of T cells (HP:0002843) | 1.82573457 |
165 | Long foot (HP:0001833) | 1.82444673 |
166 | Chest pain (HP:0100749) | 1.82012012 |
167 | Elevated hepatic transaminases (HP:0002910) | 1.81401255 |
168 | Bone cyst (HP:0012062) | 1.81256785 |
169 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.80568555 |
170 | Pigmentary retinal degeneration (HP:0001146) | 1.79656372 |
171 | Growth hormone excess (HP:0000845) | 1.79624083 |
172 | Abnormality of the fingertips (HP:0001211) | 1.79564311 |
173 | Striae distensae (HP:0001065) | 1.79458780 |
174 | Neonatal hypoglycemia (HP:0001998) | 1.78772553 |
175 | Alveolar cell carcinoma (HP:0006519) | 1.77972716 |
176 | Abnormal glucose tolerance (HP:0001952) | 1.77318946 |
177 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.76763394 |
178 | Anorexia (HP:0002039) | 1.73547507 |
179 | Colitis (HP:0002583) | 1.71031972 |
180 | Slow saccadic eye movements (HP:0000514) | 1.70845010 |
181 | Progressive cerebellar ataxia (HP:0002073) | 1.70570944 |
182 | Truncal obesity (HP:0001956) | 1.69621695 |
Rank | Gene Set | Z-score |
---|---|---|
1 | INSRR | 4.54920790 |
2 | CAMK1D | 3.68667256 |
3 | TGFBR2 | 3.50423941 |
4 | SIK1 | 2.99052009 |
5 | CAMKK2 | 2.74613549 |
6 | CAMK1G | 2.71364872 |
7 | BCKDK | 2.62754077 |
8 | FRK | 2.60533473 |
9 | TAOK3 | 2.57055389 |
10 | TRIB3 | 2.56863192 |
11 | FGFR4 | 2.49706065 |
12 | IRAK3 | 2.31943458 |
13 | MAPK15 | 2.27463211 |
14 | ERN1 | 2.21147707 |
15 | JAK1 | 2.20340671 |
16 | FGFR3 | 2.02940954 |
17 | TXK | 2.02822221 |
18 | ITK | 1.89980905 |
19 | MAP4K1 | 1.89786819 |
20 | RIPK4 | 1.84696842 |
21 | FES | 1.76409713 |
22 | TYK2 | 1.69178972 |
23 | ACVR1B | 1.62571055 |
24 | MAP4K2 | 1.60277753 |
25 | BLK | 1.58986153 |
26 | JAK3 | 1.54237450 |
27 | NEK9 | 1.50998135 |
28 | PKN2 | 1.49549726 |
29 | FLT3 | 1.44251894 |
30 | JAK2 | 1.43755037 |
31 | MAP3K14 | 1.41478751 |
32 | CSF1R | 1.39307029 |
33 | CAMKK1 | 1.31954575 |
34 | FGFR2 | 1.31625501 |
35 | YES1 | 1.28709876 |
36 | CDK9 | 1.28488925 |
37 | PTK6 | 1.23396249 |
38 | PRKAA2 | 1.20470670 |
39 | MAP3K10 | 1.19283210 |
40 | ZAP70 | 1.19147490 |
41 | CSK | 1.18262935 |
42 | IRAK1 | 1.17534568 |
43 | PIK3CG | 1.17491658 |
44 | CDK6 | 1.13791455 |
45 | PDK3 | 1.12399968 |
46 | PDK4 | 1.12399968 |
47 | PRKCH | 1.07770264 |
48 | HIPK2 | 1.07128862 |
49 | MARK3 | 1.06646600 |
50 | IRAK4 | 1.06287209 |
51 | EPHA3 | 1.04061780 |
52 | MAP2K6 | 1.03188959 |
53 | PASK | 0.99949240 |
54 | TRPM7 | 0.97660906 |
55 | LATS1 | 0.97021865 |
56 | TEC | 0.96156168 |
57 | PDK2 | 0.95799776 |
58 | NLK | 0.95326709 |
59 | GRK7 | 0.93731552 |
60 | MAPK11 | 0.90188034 |
61 | PRPF4B | 0.86221017 |
62 | PDK1 | 0.85449984 |
63 | ADRBK2 | 0.84586044 |
64 | SGK3 | 0.83085530 |
65 | STK11 | 0.80765032 |
66 | WNK1 | 0.78868167 |
67 | CAMK4 | 0.78431249 |
68 | PDGFRA | 0.78161848 |
69 | PINK1 | 0.76162436 |
70 | IKBKE | 0.75987298 |
71 | PRKAA1 | 0.75245844 |
72 | STK10 | 0.75219825 |
73 | IGF1R | 0.74383141 |
74 | MAP3K2 | 0.72397753 |
75 | TBK1 | 0.71609034 |
76 | CAMK1 | 0.71361484 |
77 | SGK2 | 0.71270021 |
78 | KIT | 0.71221515 |
79 | LCK | 0.70597319 |
80 | PAK3 | 0.69485343 |
81 | GRK1 | 0.69317880 |
82 | MELK | 0.68408546 |
83 | AKT3 | 0.66185406 |
84 | BTK | 0.65239621 |
85 | CHUK | 0.65186484 |
86 | PIM1 | 0.65167892 |
87 | IRAK2 | 0.63412072 |
88 | GSK3A | 0.62558766 |
89 | PDPK1 | 0.62109637 |
90 | EEF2K | 0.58239549 |
91 | PDGFRB | 0.57992245 |
92 | SYK | 0.56528944 |
93 | CDK4 | 0.56506884 |
94 | HCK | 0.56363255 |
95 | SGK223 | 0.55788473 |
96 | SGK494 | 0.55788473 |
97 | WNK3 | 0.55414438 |
98 | DAPK2 | 0.55369613 |
99 | RPS6KB1 | 0.54809377 |
100 | TYRO3 | 0.54561700 |
101 | STK4 | 0.53962982 |
102 | BMPR2 | 0.53918320 |
103 | TAOK1 | 0.53898141 |
104 | RET | 0.53563749 |
105 | MARK2 | 0.52621430 |
106 | GRK6 | 0.52610440 |
107 | SGK1 | 0.52309049 |
108 | NUAK1 | 0.52288799 |
109 | MTOR | 0.51336962 |
110 | RIPK1 | 0.50749681 |
111 | PRKD3 | 0.50507852 |
112 | BMPR1B | 0.49444429 |
113 | MAPK7 | 0.48768951 |
114 | PIK3CA | 0.48612085 |
115 | MAP2K2 | 0.48466911 |
116 | MAP3K4 | 0.46781345 |
117 | CDK12 | 0.46429276 |
118 | MST1R | 0.45313171 |
119 | NEK6 | 0.44999475 |
120 | MAP3K1 | 0.44102017 |
121 | PRKCQ | 0.43429986 |
122 | MAP3K7 | 0.43279152 |
123 | SIK3 | 0.43148593 |
124 | LYN | 0.43021762 |
125 | MKNK2 | 0.42605307 |
126 | MAP2K3 | 0.42374400 |
127 | PRKD2 | 0.41329079 |
128 | INSR | 0.41160684 |
129 | BRD4 | 0.40806999 |
130 | TNK2 | 0.39736263 |
131 | EPHB1 | 0.37961797 |
132 | EIF2AK2 | 0.37226743 |
133 | * PRKACG | 0.37086604 |
134 | IKBKB | 0.37069007 |
135 | MAP3K6 | 0.35555898 |
136 | MAP3K13 | 0.34646178 |
137 | STK3 | 0.31286419 |
138 | MAPK12 | 0.31065705 |
139 | MAPK4 | 0.30378533 |
140 | ERBB4 | 0.29791421 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 3.31162863 |
2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.04933009 |
3 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.94580206 |
4 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.91311137 |
5 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.90099735 |
6 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.86939129 |
7 | PPAR signaling pathway_Homo sapiens_hsa03320 | 2.84403729 |
8 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.83505711 |
9 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.52152770 |
10 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.50344242 |
11 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.41779909 |
12 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 2.20943528 |
13 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.06948847 |
14 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.99206929 |
15 | Peroxisome_Homo sapiens_hsa04146 | 1.87531593 |
16 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.85529140 |
17 | ABC transporters_Homo sapiens_hsa02010 | 1.80466361 |
18 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.80224065 |
19 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.79533524 |
20 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.78704247 |
21 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.65445985 |
22 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.57238759 |
23 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.52947768 |
24 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.52668130 |
25 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.50486883 |
26 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.48386526 |
27 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.47639487 |
28 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.46720629 |
29 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.44912119 |
30 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.44054113 |
31 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.42679063 |
32 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.42513772 |
33 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.40942920 |
34 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.38778720 |
35 | * Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.34603401 |
36 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.32398890 |
37 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.32268795 |
38 | Lysine degradation_Homo sapiens_hsa00310 | 1.31801187 |
39 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.30761688 |
40 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.26530723 |
41 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.22278313 |
42 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.21865932 |
43 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.21597183 |
44 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.18973133 |
45 | Histidine metabolism_Homo sapiens_hsa00340 | 1.16794208 |
46 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.16527226 |
47 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.15475708 |
48 | Insulin resistance_Homo sapiens_hsa04931 | 1.15279103 |
49 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.12647820 |
50 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.11708558 |
51 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.11339946 |
52 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.11183502 |
53 | Circadian rhythm_Homo sapiens_hsa04710 | 1.09460486 |
54 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.09281345 |
55 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.09035434 |
56 | Allograft rejection_Homo sapiens_hsa05330 | 1.00215387 |
57 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.99919516 |
58 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.99469861 |
59 | Retinol metabolism_Homo sapiens_hsa00830 | 0.98002070 |
60 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.96357827 |
61 | Platelet activation_Homo sapiens_hsa04611 | 0.94084345 |
62 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.90562465 |
63 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.88040597 |
64 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.87415460 |
65 | Carbon metabolism_Homo sapiens_hsa01200 | 0.85816310 |
66 | Bile secretion_Homo sapiens_hsa04976 | 0.82467875 |
67 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.82365101 |
68 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.81712966 |
69 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.81460395 |
70 | Tuberculosis_Homo sapiens_hsa05152 | 0.80739960 |
71 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.78667293 |
72 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.75043255 |
73 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.74400612 |
74 | Hepatitis C_Homo sapiens_hsa05160 | 0.73045430 |
75 | Prion diseases_Homo sapiens_hsa05020 | 0.69975274 |
76 | Other glycan degradation_Homo sapiens_hsa00511 | 0.69151480 |
77 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.68160044 |
78 | Hepatitis B_Homo sapiens_hsa05161 | 0.67880966 |
79 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.66811348 |
80 | * Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.64622855 |
81 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.64141687 |
82 | Influenza A_Homo sapiens_hsa05164 | 0.63905950 |
83 | Malaria_Homo sapiens_hsa05144 | 0.63143964 |
84 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.63098394 |
85 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.60993715 |
86 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.59995748 |
87 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.59010110 |
88 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.58709434 |
89 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.58433353 |
90 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.57735846 |
91 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.57448480 |
92 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.56024268 |
93 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.54846852 |
94 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.54644747 |
95 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.53816741 |
96 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.51907736 |
97 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.51542771 |
98 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.51255141 |
99 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.50067333 |
100 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.48665755 |
101 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.48592238 |
102 | Lysosome_Homo sapiens_hsa04142 | 0.47925291 |
103 | * Insulin signaling pathway_Homo sapiens_hsa04910 | 0.47830176 |
104 | Endometrial cancer_Homo sapiens_hsa05213 | 0.46848631 |
105 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.45961569 |
106 | * Renin secretion_Homo sapiens_hsa04924 | 0.45533904 |
107 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.44142634 |
108 | Legionellosis_Homo sapiens_hsa05134 | 0.43105600 |
109 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.42956423 |
110 | Colorectal cancer_Homo sapiens_hsa05210 | 0.42283789 |
111 | Measles_Homo sapiens_hsa05162 | 0.42099906 |
112 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.41528795 |
113 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.41169271 |
114 | Phototransduction_Homo sapiens_hsa04744 | 0.41112528 |
115 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.40175671 |
116 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.39537846 |
117 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.37675826 |
118 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.36809110 |
119 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.34772666 |
120 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.34311773 |
121 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.33919057 |
122 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.33270681 |
123 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.33256852 |
124 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.32882790 |
125 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.29816561 |
126 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.29320224 |
127 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.27613033 |
128 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.25644501 |
129 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.25312051 |
130 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.25240653 |
131 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.24138484 |
132 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.23801383 |
133 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.23789412 |
134 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.23274559 |
135 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.22511186 |
136 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.21424261 |
137 | Leishmaniasis_Homo sapiens_hsa05140 | 0.20834332 |
138 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.20111512 |
139 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.17566811 |
140 | Pertussis_Homo sapiens_hsa05133 | 0.16648044 |