PDE4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.34043519
2synaptic vesicle maturation (GO:0016188)5.01897827
3vocalization behavior (GO:0071625)4.93337421
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.91619685
5synaptic vesicle exocytosis (GO:0016079)4.88492966
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.75407827
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.70144932
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.68155014
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.65102640
10locomotory exploration behavior (GO:0035641)4.61947249
11glutamate secretion (GO:0014047)4.59721624
12regulation of synapse structural plasticity (GO:0051823)4.46199490
13regulation of glutamate receptor signaling pathway (GO:1900449)4.35836725
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.24865641
15cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.21603969
16regulation of synaptic vesicle exocytosis (GO:2000300)4.20657821
17protein localization to synapse (GO:0035418)4.14001931
18glutamate receptor signaling pathway (GO:0007215)3.94724800
19regulation of synaptic vesicle transport (GO:1902803)3.89364233
20neuron cell-cell adhesion (GO:0007158)3.87366014
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85437631
22synaptic transmission, glutamatergic (GO:0035249)3.84998148
23neuronal action potential propagation (GO:0019227)3.82757718
24activation of protein kinase A activity (GO:0034199)3.81389424
25cell communication by electrical coupling (GO:0010644)3.80142725
26regulation of neuronal synaptic plasticity (GO:0048168)3.79131537
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.79006047
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.72135529
29regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.70134056
30membrane depolarization during action potential (GO:0086010)3.69933434
31neurotransmitter secretion (GO:0007269)3.69450014
32negative regulation of erythrocyte differentiation (GO:0045647)3.69084402
33response to peptidoglycan (GO:0032494)3.68300281
34cellular potassium ion homeostasis (GO:0030007)3.67952806
35neuron-neuron synaptic transmission (GO:0007270)3.67160327
36* sensory perception of smell (GO:0007608)3.66698248
37regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.63540088
38detection of calcium ion (GO:0005513)3.61908753
39macrophage activation involved in immune response (GO:0002281)3.60396857
40long-term memory (GO:0007616)3.59171689
41exploration behavior (GO:0035640)3.58469026
42negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.55307268
43regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.52295507
44regulation of T-helper 2 cell differentiation (GO:0045628)3.51062962
45negative regulation of cytosolic calcium ion concentration (GO:0051481)3.50948416
46negative regulation of interleukin-12 production (GO:0032695)3.50722698
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.50554362
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.49113576
49sodium ion export (GO:0071436)3.48557620
50positive regulation of synapse maturation (GO:0090129)3.43118314
51neurotransmitter-gated ion channel clustering (GO:0072578)3.42166148
52positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.41996270
53regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.41281777
54cellular response to thyroid hormone stimulus (GO:0097067)3.41206605
55regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.40590445
56negative regulation of cell killing (GO:0031342)3.39889289
57negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.39889289
58lipopolysaccharide-mediated signaling pathway (GO:0031663)3.33630043
59regulation of membrane repolarization (GO:0060306)3.33478967
60regulation of postsynaptic membrane potential (GO:0060078)3.31928254
61regulation of cell communication by electrical coupling (GO:0010649)3.29767231
62positive regulation of membrane potential (GO:0045838)3.27598132
63regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.23470955
64regulation of vitamin D biosynthetic process (GO:0060556)3.23086650
65regulation of synaptic plasticity (GO:0048167)3.22270908
66gamma-aminobutyric acid signaling pathway (GO:0007214)3.22040765
67sarcoplasmic reticulum calcium ion transport (GO:0070296)3.21845155
68regulation of voltage-gated calcium channel activity (GO:1901385)3.19814542
69gamma-aminobutyric acid transport (GO:0015812)3.19706527
70regulation of dendritic spine morphogenesis (GO:0061001)3.17362482
71layer formation in cerebral cortex (GO:0021819)3.17229335
72cerebellar Purkinje cell differentiation (GO:0021702)3.16810774
73dendritic spine morphogenesis (GO:0060997)3.16279770
74membrane depolarization (GO:0051899)3.14839575
75cell communication involved in cardiac conduction (GO:0086065)3.13402640
76positive regulation of potassium ion transmembrane transport (GO:1901381)3.12433076
77positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.12267384
78G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.11693247
79positive regulation of neurotransmitter secretion (GO:0001956)3.11342163
80regulation of calcium ion transmembrane transport (GO:1903169)3.10935210
81regulation of calcium ion transmembrane transporter activity (GO:1901019)3.10935210
82glycine transport (GO:0015816)3.10748366
83potassium ion import (GO:0010107)3.10351861
84protein localization to endosome (GO:0036010)3.10091339
85proline transport (GO:0015824)3.09562575
86positive regulation of neurotransmitter transport (GO:0051590)3.08351069
87positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.07713977
88positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.07464290
89positive regulation of gamma-delta T cell activation (GO:0046645)3.06284428
90regulation of neurotransmitter secretion (GO:0046928)3.05960403
91neuron recognition (GO:0008038)3.05674334
92neurotransmitter transport (GO:0006836)3.04737742
93transmission of nerve impulse (GO:0019226)3.02128749
94synaptic vesicle endocytosis (GO:0048488)3.00118796
95positive regulation by symbiont of host defense response (GO:0052509)3.00008512
96modulation by symbiont of host defense response (GO:0052031)3.00008512
97modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.00008512
98modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.00008512
99positive regulation by organism of defense response of other organism involved in symbiotic interact3.00008512
100modulation by symbiont of host immune response (GO:0052553)3.00008512
101regulation of early endosome to late endosome transport (GO:2000641)2.98141584
102behavioral response to cocaine (GO:0048148)2.97615654
103regulation of synaptic transmission, glutamatergic (GO:0051966)2.96345372
104germinal center formation (GO:0002467)2.96305514
105barbed-end actin filament capping (GO:0051016)2.95660892
106negative regulation of synaptic transmission, GABAergic (GO:0032229)2.95315652
107cardiac muscle contraction (GO:0060048)2.94991777
108long-term synaptic potentiation (GO:0060291)2.94008759
109regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92446869
110striatum development (GO:0021756)2.92222155
111NIK/NF-kappaB signaling (GO:0038061)2.91759623
112regulation of vesicle fusion (GO:0031338)2.91341894
113regulation of synapse maturation (GO:0090128)2.91006412
114response to acidic pH (GO:0010447)2.88485922
115positive regulation of type 2 immune response (GO:0002830)2.85175281
116regulation of neurotransmitter transport (GO:0051588)2.84452748
117auditory behavior (GO:0031223)2.84066464
118negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.83659289
119myeloid dendritic cell differentiation (GO:0043011)2.83433907
120synaptic transmission (GO:0007268)2.83091925
121regulation of neurotransmitter levels (GO:0001505)2.81328216
122regulation of ARF protein signal transduction (GO:0032012)2.81234652
123behavioral fear response (GO:0001662)2.81220781
124behavioral defense response (GO:0002209)2.81220781
125positive regulation of dendritic spine development (GO:0060999)2.81104459
126regulation of dendritic spine development (GO:0060998)2.81022280
127plasma membrane repair (GO:0001778)2.80486942
128neuromuscular process controlling balance (GO:0050885)2.80261057
129negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.79861996
130positive regulation of chemokine biosynthetic process (GO:0045080)2.77657666
131adenosine receptor signaling pathway (GO:0001973)2.77570622
132response to muramyl dipeptide (GO:0032495)2.76720792
133regulation of mast cell degranulation (GO:0043304)2.73394808
134T-helper 1 type immune response (GO:0042088)2.68603056
135mannose metabolic process (GO:0006013)2.67201839
136positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.66638982
137regulation of membrane protein ectodomain proteolysis (GO:0051043)2.62878427
138virion attachment to host cell (GO:0019062)2.61266290
139adhesion of symbiont to host cell (GO:0044650)2.61266290
140positive regulation of protein dephosphorylation (GO:0035307)2.60815901
141neutrophil activation involved in immune response (GO:0002283)2.60688374
142activation of MAPKKK activity (GO:0000185)2.59212676
143L-amino acid import (GO:0043092)2.59124269
144regulation of leukocyte degranulation (GO:0043300)2.58325932
145stress fiber assembly (GO:0043149)2.57856214
146negative regulation of cytokine production involved in immune response (GO:0002719)2.56960123
147positive regulation of mast cell degranulation (GO:0043306)2.56253063
148positive regulation of mast cell activation involved in immune response (GO:0033008)2.56253063
149positive regulation of cellular amide metabolic process (GO:0034250)2.56131139
150response to thyroid hormone (GO:0097066)2.55643876
151regulation of type 2 immune response (GO:0002828)2.52777963
152glycosphingolipid catabolic process (GO:0046479)2.52075044
153positive regulation of mast cell activation (GO:0033005)2.48099309
154myeloid cell activation involved in immune response (GO:0002275)2.45129522
155modulation by symbiont of host cellular process (GO:0044068)2.44920285
156regulation of regulated secretory pathway (GO:1903305)2.44503994
157interferon-gamma-mediated signaling pathway (GO:0060333)2.44415949
158regulation of myeloid leukocyte mediated immunity (GO:0002886)2.43177034
159cytoskeletal anchoring at plasma membrane (GO:0007016)2.42148881
160regulation of mast cell activation involved in immune response (GO:0033006)2.41736433
161regulation of mononuclear cell migration (GO:0071675)2.40735838
162cortical actin cytoskeleton organization (GO:0030866)2.39867342
163regulation of chemokine biosynthetic process (GO:0045073)2.38769458
164regulation of podosome assembly (GO:0071801)2.36022989
165positive regulation of leukocyte degranulation (GO:0043302)2.35776057
166amino acid import (GO:0043090)2.33862763
167regulation of vitamin metabolic process (GO:0030656)2.33393032
168adhesion of symbiont to host (GO:0044406)2.32330202
169positive regulation of fibroblast migration (GO:0010763)2.30719193
170response to laminar fluid shear stress (GO:0034616)2.30691584
171regulation of gamma-delta T cell activation (GO:0046643)2.29893949
172regulation of macrophage cytokine production (GO:0010935)2.29287161
173positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.27540993
174signal complex assembly (GO:0007172)2.27368899
175macrophage activation (GO:0042116)2.26124324
176myeloid dendritic cell activation (GO:0001773)2.25336142
177regulation of interleukin-2 biosynthetic process (GO:0045076)2.25328492
178regulation of ARF GTPase activity (GO:0032312)2.24444168
179regulation of macrophage chemotaxis (GO:0010758)2.24104366
180immunoglobulin mediated immune response (GO:0016064)2.23671650
181glycolipid catabolic process (GO:0019377)2.23172520
182detection of molecule of bacterial origin (GO:0032490)2.23103240
183cellular response to nerve growth factor stimulus (GO:1990090)2.22771873
184response to nerve growth factor (GO:1990089)2.22771873
185positive regulation of heat generation (GO:0031652)2.20753960
186antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.20443029
187positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.20421154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.87334807
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.41020084
3GBX2_23144817_ChIP-Seq_PC3_Human3.32086720
4DROSHA_22980978_ChIP-Seq_HELA_Human3.01470968
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82535273
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80981651
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73536163
8LXR_22292898_ChIP-Seq_THP-1_Human2.71494442
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.61336717
10* RARB_27405468_Chip-Seq_BRAIN_Mouse2.59873144
11REST_21632747_ChIP-Seq_MESCs_Mouse2.56464954
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49125874
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49125874
14* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.48256006
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38573924
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37428016
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35988800
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32491343
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28670840
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.20885094
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20020231
22* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17003176
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13534073
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12633842
25* EZH2_27294783_Chip-Seq_ESCs_Mouse2.11447954
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.10828479
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09844531
28VDR_21846776_ChIP-Seq_THP-1_Human2.09166811
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08444134
30IRF8_22096565_ChIP-ChIP_GC-B_Human2.03721176
31* KDM2B_26808549_Chip-Seq_DND41_Human2.02741014
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.00985396
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00883206
34EED_16625203_ChIP-ChIP_MESCs_Mouse2.00281187
35* ELK3_25401928_ChIP-Seq_HUVEC_Human1.97534757
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.93810473
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90511620
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87514548
39* TCF7_22412390_ChIP-Seq_EML_Mouse1.85588248
40* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84881130
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.81629974
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79215051
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.77563783
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75871360
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74673185
46SPI1_23127762_ChIP-Seq_K562_Human1.73844141
47VDR_24763502_ChIP-Seq_THP-1_Human1.72705748
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70987026
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69710690
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69336389
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66968769
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65264849
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63905460
54* MYC_22102868_ChIP-Seq_BL_Human1.59901342
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.58072628
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57895386
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56680363
58SMAD4_21799915_ChIP-Seq_A2780_Human1.56364243
59* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55759628
60* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55047060
61AR_21572438_ChIP-Seq_LNCaP_Human1.54648391
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52608487
63TAF15_26573619_Chip-Seq_HEK293_Human1.51136365
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51008262
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50912271
66* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48444725
67MAF_26560356_Chip-Seq_TH1_Human1.47424382
68* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44737487
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44645149
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40694257
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39329626
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38930764
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38614756
74* KDM2B_26808549_Chip-Seq_JURKAT_Human1.38268055
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37678485
76* GATA1_19941827_ChIP-Seq_MEL_Mouse1.36835618
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.36570570
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36526452
79RACK7_27058665_Chip-Seq_MCF-7_Human1.36489232
80SMC4_20622854_ChIP-Seq_HELA_Human1.35869305
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35605149
82* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33440522
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.32297751
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31574059
85GATA1_19941826_ChIP-Seq_K562_Human1.30866666
86* P68_20966046_ChIP-Seq_HELA_Human1.30570865
87ZNF274_21170338_ChIP-Seq_K562_Hela1.30545728
88* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30225130
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29863127
90* ELF1_20517297_ChIP-Seq_JURKAT_Human1.28710311
91* RUNX1_22412390_ChIP-Seq_EML_Mouse1.28392130
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26601118
93* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25602166
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.24954515
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.23326857
96* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22858851
97RING1B_27294783_Chip-Seq_ESCs_Mouse1.22345833
98* MAF_26560356_Chip-Seq_TH2_Human1.20880102
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20295408
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19067744
101* BCOR_27268052_Chip-Seq_Bcells_Human1.19018057
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19003483
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18783299
104TET1_21451524_ChIP-Seq_MESCs_Mouse1.18516928
105RUNX_20019798_ChIP-Seq_JUKART_Human1.18432897
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.17963287
107BCL6_27268052_Chip-Seq_Bcells_Human1.16713613
108AR_19668381_ChIP-Seq_PC3_Human1.16113277
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16017262
110WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15990652
111VDR_24787735_ChIP-Seq_THP-1_Human1.14595840
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14487394
113* UTX_26944678_Chip-Seq_JUKART_Human1.14235478
114* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14100198
115ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13880055
116ERG_21242973_ChIP-ChIP_JURKAT_Human1.13828679
117DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13442780
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13228828
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12527122
120STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11558280
121NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11033129
122STAT3_23295773_ChIP-Seq_U87_Human1.09853003
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09548355
124* KDM2B_26808549_Chip-Seq_K562_Human1.09464155
125P300_19829295_ChIP-Seq_ESCs_Human1.09194211
126PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08695713
127* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08543952
128NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08468660
129SA1_27219007_Chip-Seq_Bcells_Human1.07508991
130AHR_22903824_ChIP-Seq_MCF-7_Human1.07051830
131ARNT_22903824_ChIP-Seq_MCF-7_Human1.05414137
132TCF4_23295773_ChIP-Seq_U87_Human1.05377846
133NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04638161
134P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04139769
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03554837
136ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03377904
137GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03280838
138PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01299683
139CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00501305
140ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00167089
141CBX2_27304074_Chip-Seq_ESCs_Mouse0.99984149
142P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99777225
143CLOCK_20551151_ChIP-Seq_293T_Human0.98909526
144SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98903321
145THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98843806
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98663572
147* CREB1_26743006_Chip-Seq_LNCaP_Human0.98626684
148AR_25329375_ChIP-Seq_VCAP_Human0.98509265
149LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98338978
150TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98237544
151SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98171003
152CTCF_27219007_Chip-Seq_Bcells_Human0.98095709
153GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97544672
154SMAD3_21741376_ChIP-Seq_HESCs_Human0.97507136
155CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97210063
156RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95397593
157TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94940144
158CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94334624
159TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93117604
160POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93117604
161SMAD4_21741376_ChIP-Seq_HESCs_Human0.92933347
162CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92348072
163* PRDM14_20953172_ChIP-Seq_ESCs_Human0.92246149
164PIAS1_25552417_ChIP-Seq_VCAP_Human0.90620268
165* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89490200
166SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89450125
167SMAD_19615063_ChIP-ChIP_OVARY_Human0.87812301
168ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87030683
169ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85703003
170OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85629434
171SMAD3_21741376_ChIP-Seq_ESCs_Human0.84737996
172* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84518643
173RING1B_27294783_Chip-Seq_NPCs_Mouse0.84377042
174SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83834631
175UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83577678
176WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83376919
177RUNX2_22187159_ChIP-Seq_PCA_Human0.81665872
178TET1_21490601_ChIP-Seq_MESCs_Mouse0.81155552
179BMI1_23680149_ChIP-Seq_NPCS_Mouse0.80558911
180RNF2_27304074_Chip-Seq_NSC_Mouse0.77827904

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.90474550
2MP0003880_abnormal_central_pattern4.39581360
3MP0003635_abnormal_synaptic_transmissio3.74709957
4MP0003303_peritoneal_inflammation3.60867695
5MP0001984_abnormal_olfaction3.22438644
6MP0009745_abnormal_behavioral_response3.09822751
7MP0005058_abnormal_lysosome_morphology3.09242406
8MP0006082_CNS_inflammation3.01619590
9MP0003436_decreased_susceptibility_to3.00611561
10MP0002837_dystrophic_cardiac_calcinosis2.99367612
11MP0000751_myopathy2.92072656
12MP0002064_seizures2.91350748
13MP0002063_abnormal_learning/memory/cond2.91003143
14MP0004270_analgesia2.86165399
15MP0009046_muscle_twitch2.84510813
16MP0002822_catalepsy2.80100905
17MP0003646_muscle_fatigue2.78493297
18MP0005451_abnormal_body_composition2.58425857
19MP0002272_abnormal_nervous_system2.47804411
20MP0002572_abnormal_emotion/affect_behav2.45127050
21MP0001486_abnormal_startle_reflex2.36675486
22MP0004215_abnormal_myocardial_fiber2.35112424
23MP0001968_abnormal_touch/_nociception2.31476694
24MP0009840_abnormal_foam_cell2.29911786
25MP0005423_abnormal_somatic_nervous2.28518944
26MP0003172_abnormal_lysosome_physiology2.24141060
27MP0002148_abnormal_hypersensitivity_rea2.19102316
28MP0000604_amyloidosis2.12923302
29MP0002734_abnormal_mechanical_nocicepti2.11955257
30MP0005000_abnormal_immune_tolerance2.08247715
31MP0005671_abnormal_response_to2.05894475
32MP0002419_abnormal_innate_immunity2.05051962
33MP0003690_abnormal_glial_cell2.04544431
34MP0003300_gastrointestinal_ulcer2.02732442
35MP0009785_altered_susceptibility_to2.00310295
36MP0001790_abnormal_immune_system1.97725456
37MP0005387_immune_system_phenotype1.97725456
38MP0001501_abnormal_sleep_pattern1.94528673
39MP0001835_abnormal_antigen_presentation1.92651029
40MP0009278_abnormal_bone_marrow1.89769206
41MP0000343_altered_response_to1.85734996
42MP0003724_increased_susceptibility_to1.83824847
43MP0008569_lethality_at_weaning1.83248135
44MP0001440_abnormal_grooming_behavior1.82653839
45MP0004145_abnormal_muscle_electrophysio1.80485467
46MP0005025_abnormal_response_to1.79687295
47MP0004084_abnormal_cardiac_muscle1.79192555
48MP0002735_abnormal_chemical_nociception1.79085686
49MP0002736_abnormal_nociception_after1.77932757
50MP0002067_abnormal_sensory_capabilities1.73957103
51MP0004036_abnormal_muscle_relaxation1.72307178
52MP0001533_abnormal_skeleton_physiology1.69927073
53MP0005166_decreased_susceptibility_to1.65530842
54MP0003705_abnormal_hypodermis_morpholog1.64305322
55MP0000749_muscle_degeneration1.63531238
56MP0002909_abnormal_adrenal_gland1.63239797
57MP0001970_abnormal_pain_threshold1.62221132
58MP0000685_abnormal_immune_system1.61745510
59MP0002998_abnormal_bone_remodeling1.58879135
60MP0003137_abnormal_impulse_conducting1.58442585
61MP0005646_abnormal_pituitary_gland1.57072311
62MP0005167_abnormal_blood-brain_barrier1.56582931
63MP0004947_skin_inflammation1.54813190
64MP0002184_abnormal_innervation1.54556942
65MP0002723_abnormal_immune_serum1.52695807
66MP0005386_behavior/neurological_phenoty1.49910669
67MP0004924_abnormal_behavior1.49910669
68MP0002557_abnormal_social/conspecific_i1.49174475
69MP0004085_abnormal_heartbeat1.48806074
70MP0004811_abnormal_neuron_physiology1.48649679
71MP0002452_abnormal_antigen_presenting1.48528732
72MP0004233_abnormal_muscle_weight1.45461924
73MP0004484_altered_response_of1.43807031
74MP0009780_abnormal_chondrocyte_physiolo1.41979715
75MP0008260_abnormal_autophagy1.41692094
76MP0003329_amyloid_beta_deposits1.39881771
77MP0003191_abnormal_cellular_cholesterol1.39497442
78MP0002733_abnormal_thermal_nociception1.38203747
79MP0001800_abnormal_humoral_immune1.38165089
80MP0004510_myositis1.37847237
81MP0003879_abnormal_hair_cell1.37345730
82MP0001348_abnormal_lacrimal_gland1.36003938
83MP0004858_abnormal_nervous_system1.32774380
84MP0000778_abnormal_nervous_system1.32204336
85MP0005620_abnormal_muscle_contractility1.31744882
86MP0004142_abnormal_muscle_tone1.31455321
87MP0003828_pulmonary_edema1.30512571
88MP0005330_cardiomyopathy1.28505058
89MP0001853_heart_inflammation1.28350274
90MP0003279_aneurysm1.27686366
91MP0002420_abnormal_adaptive_immunity1.27234713
92MP0001819_abnormal_immune_cell1.26786983
93MP0002066_abnormal_motor_capabilities/c1.24573882
94MP0002882_abnormal_neuron_morphology1.24161622
95MP0002254_reproductive_system_inflammat1.23560008
96MP0009764_decreased_sensitivity_to1.23385911
97MP0003633_abnormal_nervous_system1.21235798
98MP0004087_abnormal_muscle_fiber1.20653632
99MP0003448_altered_tumor_morphology1.20530872
100MP0002405_respiratory_system_inflammati1.19939296
101MP0001529_abnormal_vocalization1.19045553
102MP0002972_abnormal_cardiac_muscle1.18758576
103MP0005310_abnormal_salivary_gland1.17294028
104MP0000955_abnormal_spinal_cord1.16299016
105MP0001958_emphysema1.16274844
106MP0001502_abnormal_circadian_rhythm1.16204618
107MP0000858_altered_metastatic_potential1.15969518
108MP0004130_abnormal_muscle_cell1.15905897
109MP0003091_abnormal_cell_migration1.13849498
110MP0006276_abnormal_autonomic_nervous1.13076988
111MP0009333_abnormal_splenocyte_physiolog1.12025443
112MP0002106_abnormal_muscle_physiology1.11401611
113MP0005645_abnormal_hypothalamus_physiol1.09023985
114MP0000747_muscle_weakness1.08075238
115MP0001905_abnormal_dopamine_level1.06917640
116MP0001845_abnormal_inflammatory_respons1.06783723
117MP0001545_abnormal_hematopoietic_system1.03830794
118MP0005397_hematopoietic_system_phenotyp1.03830794
119MP0008438_abnormal_cutaneous_collagen1.01756888
120MP0005551_abnormal_eye_electrophysiolog1.01017775
121MP0003787_abnormal_imprinting1.00556388
122MP0003631_nervous_system_phenotype1.00278012
123MP0005410_abnormal_fertilization1.00266294
124MP0008775_abnormal_heart_ventricle0.97986321
125MP0005464_abnormal_platelet_physiology0.97792463
126MP0008469_abnormal_protein_level0.96980746
127MP0002269_muscular_atrophy0.96956829
128MP0008874_decreased_physiological_sensi0.96751141
129MP0005369_muscle_phenotype0.96169944
130MP0003656_abnormal_erythrocyte_physiolo0.94680935
131MP0008004_abnormal_stomach_pH0.93824440
132MP0003453_abnormal_keratinocyte_physiol0.93804478
133MP0000759_abnormal_skeletal_muscle0.93431169
134MP0002229_neurodegeneration0.93010749
135MP0001188_hyperpigmentation0.92092621
136MP0005394_taste/olfaction_phenotype0.91926862
137MP0005499_abnormal_olfactory_system0.91926862
138MP0002152_abnormal_brain_morphology0.91125323
139MP0005623_abnormal_meninges_morphology0.89474962
140MP0002877_abnormal_melanocyte_morpholog0.88161485
141MP0010155_abnormal_intestine_physiology0.87725494
142MP0005535_abnormal_body_temperature0.86508642
143MP0000716_abnormal_immune_system0.86040305
144MP0005390_skeleton_phenotype0.85475373
145MP0005165_increased_susceptibility_to0.85441232
146MP0008961_abnormal_basal_metabolism0.84827690
147MP0006138_congestive_heart_failure0.84670683
148MP0005666_abnormal_adipose_tissue0.83624992
149MP0003075_altered_response_to0.82746581
150MP0002933_joint_inflammation0.80875766
151MP0005670_abnormal_white_adipose0.80177685
152MP0001542_abnormal_bone_strength0.79763947
153MP0000733_abnormal_muscle_development0.79551991
154MP0001544_abnormal_cardiovascular_syste0.79143580
155MP0005385_cardiovascular_system_phenoty0.79143580
156MP0004885_abnormal_endolymph0.78735043
157MP0000013_abnormal_adipose_tissue0.75181306
158MP0002069_abnormal_eating/drinking_beha0.73950529
159MP0002332_abnormal_exercise_endurance0.72862336
160MP0002090_abnormal_vision0.71865000
161MP0003634_abnormal_glial_cell0.71082104
162MP0001485_abnormal_pinna_reflex0.70108108
163MP0008872_abnormal_physiological_respon0.69744127
164MP0000920_abnormal_myelination0.69697285
165MP0002752_abnormal_somatic_nervous0.69246225
166MP0005409_darkened_coat_color0.62466277
167MP0010630_abnormal_cardiac_muscle0.62382436
168MP0000750_abnormal_muscle_regeneration0.62033288

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.82161555
2Myokymia (HP:0002411)5.52299063
3Focal seizures (HP:0007359)5.11651211
4Visual hallucinations (HP:0002367)4.71187309
5Abnormality of liposaccharide metabolism (HP:0010968)4.52621357
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.52621357
7Abnormality of glycolipid metabolism (HP:0010969)4.52621357
8Sudden death (HP:0001699)4.52297264
9Febrile seizures (HP:0002373)4.42410951
10Atonic seizures (HP:0010819)4.35522402
11Epileptic encephalopathy (HP:0200134)4.25655300
12Exercise-induced myalgia (HP:0003738)3.83971849
13Neurofibrillary tangles (HP:0002185)3.78758981
14Atrial fibrillation (HP:0005110)3.76699423
15Progressive cerebellar ataxia (HP:0002073)3.75102029
16Bundle branch block (HP:0011710)3.71614222
17Primary atrial arrhythmia (HP:0001692)3.65732863
18Absence seizures (HP:0002121)3.64340849
19Ventricular fibrillation (HP:0001663)3.63009704
20Syncope (HP:0001279)3.58338822
21Prolonged QT interval (HP:0001657)3.58069501
22Calf muscle hypertrophy (HP:0008981)3.48732492
23Generalized tonic-clonic seizures (HP:0002069)3.47488187
24Supraventricular tachycardia (HP:0004755)3.47401633
25Dialeptic seizures (HP:0011146)3.42101862
26Muscle hypertrophy of the lower extremities (HP:0008968)3.36783708
27Supraventricular arrhythmia (HP:0005115)3.36524424
28Abnormality of macrophages (HP:0004311)3.33940022
29Dysostosis multiplex (HP:0000943)3.28270399
30Neuronal loss in central nervous system (HP:0002529)3.25641839
31Abnormal EKG (HP:0003115)3.15514887
32Cerebral inclusion bodies (HP:0100314)3.14963152
33Increased cerebral lipofuscin (HP:0011813)3.12522584
34Broad-based gait (HP:0002136)3.04826998
35Gaze-evoked nystagmus (HP:0000640)3.04762860
36Asymmetric septal hypertrophy (HP:0001670)3.03771302
37Dysmetric saccades (HP:0000641)3.03506324
38Axonal loss (HP:0003447)3.02577462
39Loss of speech (HP:0002371)3.01561545
40Systemic lupus erythematosus (HP:0002725)2.99300462
41Genetic anticipation (HP:0003743)2.98106225
42Depression (HP:0000716)2.91259266
43Abnormality of the calf musculature (HP:0001430)2.88945495
44Dysdiadochokinesis (HP:0002075)2.88729799
45Poor eye contact (HP:0000817)2.82745355
46Dysmetria (HP:0001310)2.77738399
47Impaired vibration sensation in the lower limbs (HP:0002166)2.77673673
48Vacuolated lymphocytes (HP:0001922)2.77266327
49Type 1 muscle fiber predominance (HP:0003803)2.76921567
50Anxiety (HP:0000739)2.76268455
51Postural instability (HP:0002172)2.73933577
52Hyperventilation (HP:0002883)2.73415702
53Apathy (HP:0000741)2.73197350
54Action tremor (HP:0002345)2.70976028
55Ankle clonus (HP:0011448)2.70353396
56Exercise-induced muscle cramps (HP:0003710)2.68951532
57Centrally nucleated skeletal muscle fibers (HP:0003687)2.68924550
58Urinary bladder sphincter dysfunction (HP:0002839)2.68867193
59Retinal dysplasia (HP:0007973)2.64074292
60Supranuclear gaze palsy (HP:0000605)2.62906668
61Distal lower limb muscle weakness (HP:0009053)2.60222966
62Central scotoma (HP:0000603)2.60186510
63Heart block (HP:0012722)2.60101735
64Impaired social interactions (HP:0000735)2.59274154
65Abnormal social behavior (HP:0012433)2.59274154
66Eczematoid dermatitis (HP:0000976)2.58137083
67Myotonia (HP:0002486)2.57498767
68Obstructive sleep apnea (HP:0002870)2.57221503
69Muscle fiber inclusion bodies (HP:0100299)2.56933059
70Diminished motivation (HP:0000745)2.56895662
71Ventricular arrhythmia (HP:0004308)2.52895211
72Nemaline bodies (HP:0003798)2.52807464
73Nuclear cataract (HP:0100018)2.52189798
74Truncal ataxia (HP:0002078)2.47949587
75Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.46482357
76Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45998367
77Abnormality of polysaccharide metabolism (HP:0011012)2.45998367
78Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45998367
79Increased connective tissue (HP:0009025)2.41920473
80Disinhibition (HP:0000734)2.40271026
81Distal lower limb amyotrophy (HP:0008944)2.39649199
82Left ventricular hypertrophy (HP:0001712)2.39018417
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.38709642
84Recurrent bacterial skin infections (HP:0005406)2.36333265
85Abnormal atrioventricular conduction (HP:0005150)2.36134431
86Absent/shortened dynein arms (HP:0200106)2.35625955
87Dynein arm defect of respiratory motile cilia (HP:0012255)2.35625955
88Recurrent abscess formation (HP:0002722)2.33893756
89Progressive inability to walk (HP:0002505)2.33454465
90Ventricular tachycardia (HP:0004756)2.30515919
91Mucopolysacchariduria (HP:0008155)2.30259732
92Urinary glycosaminoglycan excretion (HP:0003541)2.30259732
93Amblyopia (HP:0000646)2.27370594
94Lower limb amyotrophy (HP:0007210)2.26555663
95Amyloidosis (HP:0011034)2.26466815
96Torticollis (HP:0000473)2.26382456
97Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.26058218
98Orchitis (HP:0100796)2.26028456
99Abnormality of skeletal muscle fiber size (HP:0012084)2.25906486
100Mutism (HP:0002300)2.25357120
101Muscle fiber splitting (HP:0003555)2.24493932
102EMG: myopathic abnormalities (HP:0003458)2.23475077
103Peripheral hypomyelination (HP:0007182)2.23206010
104Atrioventricular block (HP:0001678)2.23031290
105Pheochromocytoma (HP:0002666)2.21462935
106Palpitations (HP:0001962)2.20629315
107Slow saccadic eye movements (HP:0000514)2.20207782
108Urinary urgency (HP:0000012)2.19718668
109Stomatitis (HP:0010280)2.18462023
110Mediastinal lymphadenopathy (HP:0100721)2.17058031
111Abnormality of the nasal mucosa (HP:0000433)2.16994111
112Impaired smooth pursuit (HP:0007772)2.16698579
113Myositis (HP:0100614)2.15243869
114Abnormality of the left ventricular outflow tract (HP:0011103)2.15083219
115Subaortic stenosis (HP:0001682)2.15083219
116Difficulty running (HP:0009046)2.14784037
117Hemiplegia (HP:0002301)2.13623131
118Optic neuritis (HP:0100653)2.13603452
119Retrobulbar optic neuritis (HP:0100654)2.13603452
120Abnormality of the lower motor neuron (HP:0002366)2.13069654
121Rapidly progressive (HP:0003678)2.11528517
122Limb dystonia (HP:0002451)2.10824181
123Myopathic facies (HP:0002058)2.07918000
124Gastrointestinal stroma tumor (HP:0100723)2.07614070
125Hemiparesis (HP:0001269)2.06655516
126Focal dystonia (HP:0004373)2.06215961
127Hyporeflexia of lower limbs (HP:0002600)2.05925998
128Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03899916
129Segmental peripheral demyelination/remyelination (HP:0003481)2.03687026
130Distal upper limb amyotrophy (HP:0007149)2.03462538
131Upper limb amyotrophy (HP:0009129)2.03462538
132Tetraplegia (HP:0002445)2.02837882
133Abnormal eating behavior (HP:0100738)2.02091599
134Abnormality of binocular vision (HP:0011514)2.01659900
135Diplopia (HP:0000651)2.01659900
136Bradykinesia (HP:0002067)2.01603871
137Absent speech (HP:0001344)2.00860539
138Scanning speech (HP:0002168)1.98871552
139Vertebral compression fractures (HP:0002953)1.97153058
140Bradycardia (HP:0001662)1.96851946
141Dementia (HP:0000726)1.96762940
142Achilles tendon contracture (HP:0001771)1.96621410
143Spastic gait (HP:0002064)1.96605163
144Frequent falls (HP:0002359)1.95974890
145Abnormal gallbladder physiology (HP:0012438)1.95659771
146Cholecystitis (HP:0001082)1.95659771
147Impaired vibratory sensation (HP:0002495)1.92485426
148Increased variability in muscle fiber diameter (HP:0003557)1.91995476
149Cerebral aneurysm (HP:0004944)1.91493620
150Rigidity (HP:0002063)1.91303811
151Neuroendocrine neoplasm (HP:0100634)1.90978935
152Epileptiform EEG discharges (HP:0011182)1.90974091
153Excessive salivation (HP:0003781)1.90366844
154Drooling (HP:0002307)1.90366844
155Personality changes (HP:0000751)1.88867772
156Spondylolisthesis (HP:0003302)1.88581808
157Stereotypic behavior (HP:0000733)1.88556435
158Myoglobinuria (HP:0002913)1.88483966
159Upper motor neuron abnormality (HP:0002127)1.88345041
160Inability to walk (HP:0002540)1.88211685
161Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88142613
162Lower limb muscle weakness (HP:0007340)1.87254787
163Delusions (HP:0000746)1.85010641
164Lipoatrophy (HP:0100578)1.84303252
165Craniofacial dystonia (HP:0012179)1.83195207
166Interstitial pulmonary disease (HP:0006530)1.83029169
167Abnormal respiratory motile cilium physiology (HP:0012261)1.82756575
168Purpura (HP:0000979)1.82661022
169Abnormality of saccadic eye movements (HP:0000570)1.82473103
170Chronic obstructive pulmonary disease (HP:0006510)1.81995427
171Obstructive lung disease (HP:0006536)1.81995427
172Myocardial infarction (HP:0001658)1.80257678
173Increased serum ferritin (HP:0003281)1.79229621
174Abnormality of the periventricular white matter (HP:0002518)1.78769028
175Annular pancreas (HP:0001734)1.77883772
176Slender build (HP:0001533)1.77326155
177Bulbar palsy (HP:0001283)1.76810969
178Nasal polyposis (HP:0100582)1.73736727
179Autoimmune thrombocytopenia (HP:0001973)1.73211318
180Ulnar deviation of the wrist (HP:0003049)1.73089309
181Emphysema (HP:0002097)1.72817295
182Foot dorsiflexor weakness (HP:0009027)1.72776358
183Insomnia (HP:0100785)1.72509412

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.39618858
2NTRK34.04543922
3IRAK32.98147445
4MAP3K42.67551194
5MAP3K92.65484885
6DAPK22.52450111
7MAP2K72.34846205
8PHKG12.30785434
9PHKG22.30785434
10PRKD32.29860197
11TAOK22.27064079
12PAK62.14844396
13DDR22.14485397
14MINK12.10698830
15MAP3K112.09541988
16MARK12.07143612
17MAP3K141.97429451
18TESK11.93584401
19ERN11.82602998
20CASK1.73181996
21MAP2K31.72910837
22NTRK21.68008824
23CAMKK11.62761968
24RIPK41.60911526
25MAP2K41.60692946
26STK381.60617496
27DAPK11.60118064
28TRIB31.59909579
29PRPF4B1.59583758
30DMPK1.54177592
31TNIK1.53363124
32MAP3K121.45817515
33CDK191.44495394
34PINK11.43324341
35BLK1.41730584
36MOS1.40429733
37FES1.40149843
38LATS21.40008971
39PLK21.39238620
40TBK11.37894110
41CDK51.37648733
42NME21.37185935
43MAPK131.36308095
44MAP3K11.35460107
45TYK21.31514126
46SIK21.31257764
47LMTK21.30832108
48MAP3K31.27420625
49CAMK11.23697311
50ARAF1.23216697
51TTN1.22308643
52GRK51.21905378
53KSR21.21143713
54PDK41.20495222
55PDK31.20495222
56CAMK2A1.19752663
57MATK1.19515590
58PRKCG1.17279182
59CAMK2D1.14697096
60MAP4K11.14457775
61CAMK2B1.12510736
62PTK2B1.08544510
63CSK1.07119029
64JAK11.05741323
65PAK31.04679151
66MARK21.03635921
67SIK31.02152657
68SIK10.99433028
69FGR0.97978535
70MUSK0.96305704
71ZAP700.92415657
72TESK20.91612536
73CAMKK20.91066722
74PNCK0.88835324
75TGFBR20.88834972
76KSR10.88789456
77TAOK10.88146650
78PDGFRA0.87257953
79PRKCH0.86133048
80ICK0.84451274
81CAMK1G0.84317337
82NTRK10.84050105
83SGK2230.83840309
84SGK4940.83840309
85UHMK10.82822832
86BMPR20.82579645
87STK110.81867889
88MAP3K70.80175927
89OBSCN0.79208661
90SGK20.78887749
91RIPK10.78842831
92DAPK30.78033935
93MAPK70.77542861
94PDK10.76820980
95CAMK2G0.76775145
96CAMK40.76010800
97MAP3K130.75963898
98NEK10.75075099
99CDC42BPA0.74181111
100PDPK10.73948843
101TYRO30.73683813
102MYLK0.73680313
103TNK20.72148020
104LIMK10.71207349
105JAK20.70986761
106SGK30.70206968
107IRAK20.69372919
108BRAF0.68247369
109CDK150.67380133
110CDK180.67371556
111SGK10.67222441
112PRKCE0.67117587
113JAK30.66202042
114IRAK40.65700229
115PIM20.62530932
116MAPK120.62511028
117PRKD20.62326017
118RAF10.61091360
119PKN10.60196792
120OXSR10.60167930
121ABL20.59378210
122IKBKB0.59068285
123EEF2K0.58925932
124DYRK1A0.58471952
125CDK11A0.58423181
126CDK140.57538943
127SYK0.57409655
128ALK0.57259121
129MAP2K60.56645108
130CDK120.56478961
131MAPK40.55615877
132TIE10.53528144
133NME10.52831223
134PRKG20.52558736
135CSNK1G20.51403837
136EPHB10.51166733
137WNK10.50492660
138RPS6KA30.47192237
139PDK20.45272869
140MAP3K50.44949177
141GRK70.44898131
142SMG10.43873408
143HCK0.43565587
144PRKD10.43284596
145RET0.43124358
146MAP3K60.42613576
147RPS6KA20.41589484
148ROCK20.41203264
149MAPKAPK50.41152319

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.79238422
2Nicotine addiction_Homo sapiens_hsa050333.38209097
3Synaptic vesicle cycle_Homo sapiens_hsa047212.88525352
4Circadian entrainment_Homo sapiens_hsa047132.78761934
5GABAergic synapse_Homo sapiens_hsa047272.59043903
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58494207
7* Morphine addiction_Homo sapiens_hsa050322.49386469
8Glutamatergic synapse_Homo sapiens_hsa047242.46503307
9Long-term potentiation_Homo sapiens_hsa047202.31971570
10Other glycan degradation_Homo sapiens_hsa005112.28032482
11Osteoclast differentiation_Homo sapiens_hsa043802.18317525
12Amphetamine addiction_Homo sapiens_hsa050312.17569603
13Salivary secretion_Homo sapiens_hsa049702.09148553
14Insulin secretion_Homo sapiens_hsa049112.06143378
15Cardiac muscle contraction_Homo sapiens_hsa042602.02217874
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94502911
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.94072229
18Dopaminergic synapse_Homo sapiens_hsa047281.93105305
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92255628
20Gastric acid secretion_Homo sapiens_hsa049711.91296336
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86767986
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86356333
23Cholinergic synapse_Homo sapiens_hsa047251.84926490
24Leishmaniasis_Homo sapiens_hsa051401.84888801
25Calcium signaling pathway_Homo sapiens_hsa040201.84396831
26Taste transduction_Homo sapiens_hsa047421.83033625
27Lysosome_Homo sapiens_hsa041421.79713073
28Dilated cardiomyopathy_Homo sapiens_hsa054141.74723306
29Oxytocin signaling pathway_Homo sapiens_hsa049211.72496860
30Tuberculosis_Homo sapiens_hsa051521.67557311
31Rheumatoid arthritis_Homo sapiens_hsa053231.67100668
32Renin secretion_Homo sapiens_hsa049241.58495238
33Prion diseases_Homo sapiens_hsa050201.54022515
34Pertussis_Homo sapiens_hsa051331.48802692
35Malaria_Homo sapiens_hsa051441.48663655
36B cell receptor signaling pathway_Homo sapiens_hsa046621.47853928
37TNF signaling pathway_Homo sapiens_hsa046681.46580049
38Staphylococcus aureus infection_Homo sapiens_hsa051501.46548429
39Serotonergic synapse_Homo sapiens_hsa047261.43716480
40Allograft rejection_Homo sapiens_hsa053301.42350900
41* cAMP signaling pathway_Homo sapiens_hsa040241.42053216
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.40585881
43Salmonella infection_Homo sapiens_hsa051321.38987487
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38694955
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37272111
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36576113
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36252093
48Graft-versus-host disease_Homo sapiens_hsa053321.34974930
49GnRH signaling pathway_Homo sapiens_hsa049121.33368890
50Cocaine addiction_Homo sapiens_hsa050301.31662884
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31260617
52NF-kappa B signaling pathway_Homo sapiens_hsa040641.29756288
53Long-term depression_Homo sapiens_hsa047301.29621684
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.28909059
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.26495464
56NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22839843
57Type II diabetes mellitus_Homo sapiens_hsa049301.18709822
58Toxoplasmosis_Homo sapiens_hsa051451.18441791
59Collecting duct acid secretion_Homo sapiens_hsa049661.18231499
60Gap junction_Homo sapiens_hsa045401.17033401
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15724712
62Acute myeloid leukemia_Homo sapiens_hsa052211.15039430
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11870947
64Autoimmune thyroid disease_Homo sapiens_hsa053201.07739851
65Vascular smooth muscle contraction_Homo sapiens_hsa042701.06881359
66Legionellosis_Homo sapiens_hsa051341.06477562
67Phagosome_Homo sapiens_hsa041451.06315504
68Pancreatic secretion_Homo sapiens_hsa049721.04250945
69Estrogen signaling pathway_Homo sapiens_hsa049151.03955530
70Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03860174
71Influenza A_Homo sapiens_hsa051641.03529766
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02178833
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01924805
74Viral myocarditis_Homo sapiens_hsa054161.01229392
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99559243
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98416208
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97799415
78T cell receptor signaling pathway_Homo sapiens_hsa046600.97090817
79Type I diabetes mellitus_Homo sapiens_hsa049400.96566435
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94257178
81Asthma_Homo sapiens_hsa053100.92596545
82Phototransduction_Homo sapiens_hsa047440.92329661
83Alzheimers disease_Homo sapiens_hsa050100.91891861
84African trypanosomiasis_Homo sapiens_hsa051430.91464329
85Amoebiasis_Homo sapiens_hsa051460.91043294
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89676539
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.88695936
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88473890
89Shigellosis_Homo sapiens_hsa051310.87769112
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86910199
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86609516
92Glioma_Homo sapiens_hsa052140.84819984
93Parkinsons disease_Homo sapiens_hsa050120.83632167
94Antigen processing and presentation_Homo sapiens_hsa046120.82656396
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82203373
96Bladder cancer_Homo sapiens_hsa052190.81935276
97Melanogenesis_Homo sapiens_hsa049160.81342391
98Oxidative phosphorylation_Homo sapiens_hsa001900.81022118
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80252522
100Glucagon signaling pathway_Homo sapiens_hsa049220.79819927
101Vibrio cholerae infection_Homo sapiens_hsa051100.77269735
102Hepatitis B_Homo sapiens_hsa051610.76997386
103Axon guidance_Homo sapiens_hsa043600.76967052
104ErbB signaling pathway_Homo sapiens_hsa040120.75615272
105Chronic myeloid leukemia_Homo sapiens_hsa052200.75016401
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74254065
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72769369
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.72131107
109Hematopoietic cell lineage_Homo sapiens_hsa046400.69873445
110Thyroid hormone synthesis_Homo sapiens_hsa049180.68444311
111Apoptosis_Homo sapiens_hsa042100.66962362
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.66919977
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66727034
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66235874
115Measles_Homo sapiens_hsa051620.65925444
116Prolactin signaling pathway_Homo sapiens_hsa049170.64420221
117MAPK signaling pathway_Homo sapiens_hsa040100.63840785
118Oocyte meiosis_Homo sapiens_hsa041140.63347854
119Hepatitis C_Homo sapiens_hsa051600.62382142
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60859690
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60546677
122Dorso-ventral axis formation_Homo sapiens_hsa043200.59038444
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.58095192
124Ovarian steroidogenesis_Homo sapiens_hsa049130.56162583
125Inositol phosphate metabolism_Homo sapiens_hsa005620.55542897
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54734894
127Herpes simplex infection_Homo sapiens_hsa051680.54293915
128Insulin signaling pathway_Homo sapiens_hsa049100.53961936
129Ras signaling pathway_Homo sapiens_hsa040140.53847620
130Circadian rhythm_Homo sapiens_hsa047100.53659988
131VEGF signaling pathway_Homo sapiens_hsa043700.53332248
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52622322
133Huntingtons disease_Homo sapiens_hsa050160.52225801
134Rap1 signaling pathway_Homo sapiens_hsa040150.52010666
135Choline metabolism in cancer_Homo sapiens_hsa052310.50132631
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49622348
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.48066404
138mTOR signaling pathway_Homo sapiens_hsa041500.37191653
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36811423
140Bile secretion_Homo sapiens_hsa049760.35029813
141Endocytosis_Homo sapiens_hsa041440.33746617
142Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32186849
143Fatty acid biosynthesis_Homo sapiens_hsa000610.31116255
144Renal cell carcinoma_Homo sapiens_hsa052110.30367007
145Nitrogen metabolism_Homo sapiens_hsa009100.29864783
146Non-small cell lung cancer_Homo sapiens_hsa052230.29083025
147HIF-1 signaling pathway_Homo sapiens_hsa040660.28733123
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.28692861
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.27599051
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27273199
151Chemokine signaling pathway_Homo sapiens_hsa040620.27099747
152Platelet activation_Homo sapiens_hsa046110.26221948
153Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25769212
154Alcoholism_Homo sapiens_hsa050340.25570868
155Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24621308

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