PDE4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.23818908
2axon ensheathment in central nervous system (GO:0032291)6.23818908
3positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.58670411
4negative regulation of cell killing (GO:0031342)4.24850709
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.24850709
6negative regulation of interleukin-12 production (GO:0032695)4.22550785
7response to peptidoglycan (GO:0032494)4.16737270
8modulation by symbiont of host defense response (GO:0052031)3.99334672
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.99334672
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.99334672
11positive regulation by organism of defense response of other organism involved in symbiotic interact3.99334672
12modulation by symbiont of host immune response (GO:0052553)3.99334672
13positive regulation by symbiont of host defense response (GO:0052509)3.99334672
14regulation of B cell receptor signaling pathway (GO:0050855)3.99049259
15germinal center formation (GO:0002467)3.93329226
16myelination (GO:0042552)3.89000206
17ensheathment of neurons (GO:0007272)3.88344754
18axon ensheathment (GO:0008366)3.88344754
19macrophage activation involved in immune response (GO:0002281)3.83382388
20detection of other organism (GO:0098543)3.78336692
21detection of molecule of bacterial origin (GO:0032490)3.75205502
22cellular extravasation (GO:0045123)3.70867487
23tolerance induction (GO:0002507)3.63538601
24regulation of gamma-delta T cell activation (GO:0046643)3.58826847
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.57488854
26regulation of interferon-beta biosynthetic process (GO:0045357)3.47673608
27negative regulation of neurotransmitter secretion (GO:0046929)3.47360241
28immunoglobulin mediated immune response (GO:0016064)3.44745522
29fatty acid elongation (GO:0030497)3.40821626
30neutrophil mediated immunity (GO:0002446)3.38971162
31interferon-gamma-mediated signaling pathway (GO:0060333)3.34112509
32long-chain fatty acid biosynthetic process (GO:0042759)3.32651839
33cellular response to type I interferon (GO:0071357)3.32359029
34type I interferon signaling pathway (GO:0060337)3.32359029
35microglial cell activation (GO:0001774)3.29677216
36antigen processing and presentation of endogenous antigen (GO:0019883)3.29176335
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.29086581
38detection of bacterium (GO:0016045)3.27870093
39response to type I interferon (GO:0034340)3.26953678
40negative regulation of T-helper cell differentiation (GO:0045623)3.26525836
41negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.26525836
42macrophage activation (GO:0042116)3.26138268
43detection of external biotic stimulus (GO:0098581)3.22739508
44response to protozoan (GO:0001562)3.15845549
45neutrophil activation involved in immune response (GO:0002283)3.14585012
46regulation of interleukin-8 biosynthetic process (GO:0045414)3.10986705
47negative regulation of neurotransmitter transport (GO:0051589)3.10384040
48regulation of interferon-alpha production (GO:0032647)3.08940384
49detection of biotic stimulus (GO:0009595)3.08381932
50negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.08094974
51virion attachment to host cell (GO:0019062)3.06484395
52adhesion of symbiont to host cell (GO:0044650)3.06484395
53regulation of germinal center formation (GO:0002634)3.04981155
54negative regulation of T cell mediated immunity (GO:0002710)3.04737029
55negative regulation of lymphocyte mediated immunity (GO:0002707)3.03150078
56response to interleukin-15 (GO:0070672)3.02712116
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.02288915
58positive regulation of heat generation (GO:0031652)3.01972990
59positive regulation of interleukin-17 production (GO:0032740)3.01966928
60production of molecular mediator involved in inflammatory response (GO:0002532)3.01000887
61positive regulation of interferon-alpha production (GO:0032727)2.97919048
62positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.97383200
63presynaptic membrane assembly (GO:0097105)2.96341841
64positive regulation of interleukin-1 beta secretion (GO:0050718)2.96231040
65presynaptic membrane organization (GO:0097090)2.95229534
66JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.94214857
67myelin maintenance (GO:0043217)2.93726292
68T cell migration (GO:0072678)2.93296904
69myeloid leukocyte mediated immunity (GO:0002444)2.92138731
70membrane raft organization (GO:0031579)2.90348868
71response to muramyl dipeptide (GO:0032495)2.89318663
72regulation of gamma-delta T cell differentiation (GO:0045586)2.88699370
73negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.86055744
74interferon-gamma production (GO:0032609)2.86003451
75regulation of antigen processing and presentation (GO:0002577)2.85693457
76positive regulation of NF-kappaB import into nucleus (GO:0042346)2.85222826
77regulation of alpha-beta T cell proliferation (GO:0046640)2.84588122
78cellular response to interleukin-15 (GO:0071350)2.84394638
79regulation of vitamin D biosynthetic process (GO:0060556)2.83922817
80NIK/NF-kappaB signaling (GO:0038061)2.83635452
81Rap protein signal transduction (GO:0032486)2.83109219
82regulation of type 2 immune response (GO:0002828)2.82602827
83regulation of interleukin-12 production (GO:0032655)2.81466716
84oligodendrocyte differentiation (GO:0048709)2.80575697
85regulation of interleukin-1 beta secretion (GO:0050706)2.80205098
86positive regulation of antigen processing and presentation (GO:0002579)2.79347564
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.79226762
88positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.78721595
89positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.78690535
90peptidyl-tyrosine autophosphorylation (GO:0038083)2.78212456
91L-amino acid import (GO:0043092)2.78173304
92response to host immune response (GO:0052572)2.76366489
93response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.76366489
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.75463199
95positive regulation of interleukin-1 secretion (GO:0050716)2.74151188
96membrane assembly (GO:0071709)2.72070321
97positive regulation of cellular amide metabolic process (GO:0034250)2.72010490
98negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.71082487
99regulation of T cell tolerance induction (GO:0002664)2.69965209
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.69644901
101positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.67546316
102negative regulation of cytokine production involved in immune response (GO:0002719)2.67403711
103negative thymic T cell selection (GO:0045060)2.66898344
104positive regulation of acute inflammatory response (GO:0002675)2.66141498
105nerve growth factor signaling pathway (GO:0038180)2.65575785
106response to lipoprotein particle (GO:0055094)2.63966980
107positive regulation of T-helper cell differentiation (GO:0045624)2.63352563
108regulation of memory T cell differentiation (GO:0043380)2.61774881
109T-helper 1 type immune response (GO:0042088)2.60185378
110myeloid dendritic cell differentiation (GO:0043011)2.59669461
111regulation of interleukin-17 production (GO:0032660)2.58643303
112regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.56960421
113photoreceptor cell differentiation (GO:0046530)2.55017027
114eye photoreceptor cell differentiation (GO:0001754)2.55017027
115neutrophil activation (GO:0042119)2.54981909
116regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.51091295
117mast cell activation (GO:0045576)2.49869291
118regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.48047721
119creatine metabolic process (GO:0006600)2.47138269
120positive regulation of gamma-delta T cell activation (GO:0046645)2.46457963
121regulation of interleukin-12 biosynthetic process (GO:0045075)2.45143328
122regulation of T-helper 1 cell differentiation (GO:0045625)2.43859353
123growth hormone receptor signaling pathway (GO:0060396)2.43464415
124adhesion of symbiont to host (GO:0044406)2.40738358
125regulation of T-helper 2 cell differentiation (GO:0045628)2.39735824
126granulocyte activation (GO:0036230)2.39454320
127regulation of T-helper cell differentiation (GO:0045622)2.39006965
128membrane tubulation (GO:0097320)2.38935042
129regulation of activation of Janus kinase activity (GO:0010533)2.38438930
130myeloid dendritic cell activation (GO:0001773)2.38136864
131negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.37511133
132positive regulation of T cell cytokine production (GO:0002726)2.33954460
133regulation of dendritic cell antigen processing and presentation (GO:0002604)2.31824415
134glycosylceramide metabolic process (GO:0006677)2.30275171
135positive regulation of type 2 immune response (GO:0002830)2.29217900
136amino acid import (GO:0043090)2.27967259
137positive regulation of glial cell differentiation (GO:0045687)2.27885605
138negative regulation of protein localization to cell surface (GO:2000009)2.27051333
139negative regulation of interleukin-10 production (GO:0032693)2.25396068
140positive regulation of oligodendrocyte differentiation (GO:0048714)2.24945364
141positive regulation of pseudopodium assembly (GO:0031274)2.22179945
142positive regulation of astrocyte differentiation (GO:0048711)2.20694877
143positive regulation of lipid kinase activity (GO:0090218)2.19573932
144positive regulation of interleukin-12 production (GO:0032735)2.19343576
145positive regulation of T-helper 1 type immune response (GO:0002827)2.18487279
146regulation of heat generation (GO:0031650)2.18267980
147leukocyte migration involved in inflammatory response (GO:0002523)2.17777529
148positive regulation of T cell mediated cytotoxicity (GO:0001916)2.16218057
149* positive regulation of interleukin-2 production (GO:0032743)2.15807338
150neuron remodeling (GO:0016322)2.15503220
151lipopolysaccharide-mediated signaling pathway (GO:0031663)2.14920503
152import into cell (GO:0098657)2.13387921
153mast cell degranulation (GO:0043303)2.12495659
154mast cell activation involved in immune response (GO:0002279)2.12495659
155myeloid cell activation involved in immune response (GO:0002275)2.12411336
156positive regulation of gliogenesis (GO:0014015)2.12115515
157positive regulation of interleukin-4 production (GO:0032753)2.11679288
158lymphoid progenitor cell differentiation (GO:0002320)2.11609810
159regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.11261685
160regulation of collateral sprouting (GO:0048670)2.11088984
161leukocyte aggregation (GO:0070486)2.10886915
162astrocyte development (GO:0014002)2.10474183
163negative regulation of exocytosis (GO:0045920)2.10417528
164regulation of T-helper 1 type immune response (GO:0002825)2.10360879
165serine transport (GO:0032329)2.09483288
166B cell receptor signaling pathway (GO:0050853)2.09389680
167leukocyte degranulation (GO:0043299)2.09063240
168amyloid precursor protein metabolic process (GO:0042982)2.08605070
169cellular response to growth hormone stimulus (GO:0071378)2.08552604
170glycerophospholipid catabolic process (GO:0046475)2.07244324
171positive regulation of interleukin-10 production (GO:0032733)2.06040674
172regulation of fever generation (GO:0031620)2.05528616
173interleukin-6-mediated signaling pathway (GO:0070102)2.05237352
174negative regulation of interleukin-17 production (GO:0032700)2.05041663
175defense response to protozoan (GO:0042832)2.04834355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.85748604
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.25375210
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.04572339
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.47809566
5GBX2_23144817_ChIP-Seq_PC3_Human2.37644713
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.36819011
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.27927737
8* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24016181
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.19531831
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.17523440
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12411631
12RUNX_20019798_ChIP-Seq_JUKART_Human2.04181086
13MYB_26560356_Chip-Seq_TH2_Human2.04135050
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95879098
15TAF15_26573619_Chip-Seq_HEK293_Human1.88567586
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87956329
17IRF8_27001747_Chip-Seq_BMDM_Mouse1.83281520
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81889678
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79479699
20GATA2_21666600_ChIP-Seq_HMVEC_Human1.76477851
21SCL_19346495_ChIP-Seq_HPC-7_Human1.76399470
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75622769
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74138359
24* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72082384
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70223712
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70161548
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70092170
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69289094
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65167338
30AR_21572438_ChIP-Seq_LNCaP_Human1.63259110
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61450569
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60709696
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56153947
34VDR_24763502_ChIP-Seq_THP-1_Human1.54812113
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53670628
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51789090
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50737349
38GATA1_22025678_ChIP-Seq_K562_Human1.49997600
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48814950
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47783181
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47172686
42VDR_24787735_ChIP-Seq_THP-1_Human1.46826523
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46661979
44* MYB_26560356_Chip-Seq_TH1_Human1.44975177
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44445905
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44445905
47SPI1_23547873_ChIP-Seq_NB4_Human1.42750112
48GATA3_27048872_Chip-Seq_THYMUS_Human1.41070793
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40024029
50MAF_26560356_Chip-Seq_TH1_Human1.40001800
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35199447
52* GATA3_26560356_Chip-Seq_TH2_Human1.33901483
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33496162
54* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33445693
55* DROSHA_22980978_ChIP-Seq_HELA_Human1.32980778
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31250303
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30811895
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30512167
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30366894
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29295301
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26961311
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26726160
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26726160
64ER_23166858_ChIP-Seq_MCF-7_Human1.26613213
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26397320
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.26388300
67PU_27001747_Chip-Seq_BMDM_Mouse1.26002471
68TCF7_22412390_ChIP-Seq_EML_Mouse1.24853973
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.24235647
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24027314
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.23739788
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22950606
73* EZH2_27304074_Chip-Seq_ESCs_Mouse1.20845765
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19782461
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18675313
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18361394
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17189625
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17148308
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.16801620
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15554637
81P300_19829295_ChIP-Seq_ESCs_Human1.12033335
82* UTX_26944678_Chip-Seq_JUKART_Human1.11135895
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.10738419
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10570254
85* SMAD3_21741376_ChIP-Seq_EPCs_Human1.08053141
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07539805
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06234313
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.04352372
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.01612216
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00570235
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00277413
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00198338
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99527469
94KDM2B_26808549_Chip-Seq_DND41_Human0.98451321
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.97755783
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97456300
97IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95434371
98GATA1_19941827_ChIP-Seq_MEL_Mouse0.95123534
99AHR_22903824_ChIP-Seq_MCF-7_Human0.94235201
100STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93734794
101* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93456089
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93311819
103RXR_22108803_ChIP-Seq_LS180_Human0.92786137
104SMRT_27268052_Chip-Seq_Bcells_Human0.91720399
105* SMAD4_21799915_ChIP-Seq_A2780_Human0.91411872
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89475742
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89108715
108GATA1_19941826_ChIP-Seq_K562_Human0.88635578
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.87958785
110MYC_22102868_ChIP-Seq_BL_Human0.87719735
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87562776
112VDR_21846776_ChIP-Seq_THP-1_Human0.87487496
113TP53_16413492_ChIP-PET_HCT116_Human0.86796775
114TP53_18474530_ChIP-ChIP_U2OS_Human0.86100780
115* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85640079
116P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85410149
117* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85170493
118EZH2_22144423_ChIP-Seq_EOC_Human0.84696124
119* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83754467
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83514638
121RARB_27405468_Chip-Seq_BRAIN_Mouse0.83370123
122* NANOG_18555785_Chip-Seq_ESCs_Mouse0.83003207
123SPI1_23127762_ChIP-Seq_K562_Human0.82406172
124TRIM28_21343339_ChIP-Seq_HEK293_Human0.82223470
125VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81581142
126CMYC_18555785_Chip-Seq_ESCs_Mouse0.81443205
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81294982
128* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80951126
129KDM2B_26808549_Chip-Seq_JURKAT_Human0.80688099
130SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80649177
131* EP300_21415370_ChIP-Seq_HL-1_Mouse0.80167864
132CJUN_26792858_Chip-Seq_BT549_Human0.79755509
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.79554560
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79483707
135KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.79177398
136KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.79177398
137KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.79177398
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78990466
139CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78822192
140CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78797657
141EGR1_19032775_ChIP-ChIP_M12_Human0.78503797
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.78452848
143MAF_26560356_Chip-Seq_TH2_Human0.78038273
144WT1_25993318_ChIP-Seq_PODOCYTE_Human0.77874014
145SUZ12_18555785_Chip-Seq_ESCs_Mouse0.77839666
146FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77318617
147POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.76534627
148TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76534627
149GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73607708
150FLI1_21867929_ChIP-Seq_TH2_Mouse0.71729846
151GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.70151372
152KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.69824207
153STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.69111260
154CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.68383516
155GATA2_22383799_ChIP-Seq_G1ME_Mouse0.67259142
156OCT4_21477851_ChIP-Seq_ESCs_Mouse0.61757826
157CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61395424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.68726069
2MP0003724_increased_susceptibility_to2.89541953
3MP0004510_myositis2.82215623
4MP0003880_abnormal_central_pattern2.79481552
5MP0005671_abnormal_response_to2.72974983
6MP0001835_abnormal_antigen_presentation2.59255680
7MP0002148_abnormal_hypersensitivity_rea2.49046633
8MP0009785_altered_susceptibility_to2.45936686
9MP0003690_abnormal_glial_cell2.35608542
10MP0003950_abnormal_plasma_membrane2.35449806
11MP0005387_immune_system_phenotype2.35027589
12MP0001790_abnormal_immune_system2.35027589
13MP0000685_abnormal_immune_system2.26239182
14MP0005000_abnormal_immune_tolerance2.22763717
15MP0001851_eye_inflammation2.01636368
16MP0004270_analgesia2.00471178
17MP0003303_peritoneal_inflammation1.99365995
18* MP0002419_abnormal_innate_immunity1.96803506
19MP0005025_abnormal_response_to1.95670755
20* MP0009764_decreased_sensitivity_to1.90672590
21* MP0002723_abnormal_immune_serum1.83597001
22MP0005171_absent_coat_pigmentation1.81617540
23MP0006082_CNS_inflammation1.79426143
24MP0001853_heart_inflammation1.77240920
25MP0004742_abnormal_vestibular_system1.75599056
26MP0001800_abnormal_humoral_immune1.75375827
27MP0002452_abnormal_antigen_presenting1.74778328
28MP0005409_darkened_coat_color1.72353198
29MP0000569_abnormal_digit_pigmentation1.65028909
30MP0004859_abnormal_synaptic_plasticity1.64362227
31MP0003075_altered_response_to1.59239129
32MP0001545_abnormal_hematopoietic_system1.58345429
33MP0005397_hematopoietic_system_phenotyp1.58345429
34* MP0002420_abnormal_adaptive_immunity1.57322103
35MP0004147_increased_porphyrin_level1.56978586
36MP0001486_abnormal_startle_reflex1.56797894
37* MP0001819_abnormal_immune_cell1.56062710
38MP0002272_abnormal_nervous_system1.51407960
39MP0002064_seizures1.51027741
40MP0001348_abnormal_lacrimal_gland1.49200568
41MP0008004_abnormal_stomach_pH1.47865195
42MP0002138_abnormal_hepatobiliary_system1.47737983
43MP0001905_abnormal_dopamine_level1.47148823
44MP0009745_abnormal_behavioral_response1.46956587
45MP0005310_abnormal_salivary_gland1.46920158
46MP0002254_reproductive_system_inflammat1.39338447
47MP0005166_decreased_susceptibility_to1.36094522
48MP0001501_abnormal_sleep_pattern1.34372666
49MP0004885_abnormal_endolymph1.33172403
50MP0003436_decreased_susceptibility_to1.29643775
51MP0003634_abnormal_glial_cell1.28840234
52MP0005423_abnormal_somatic_nervous1.28382833
53MP0009046_muscle_twitch1.27574922
54MP0008569_lethality_at_weaning1.24875713
55MP0003329_amyloid_beta_deposits1.23329388
56MP0003635_abnormal_synaptic_transmissio1.23201076
57MP0003828_pulmonary_edema1.23101792
58MP0005167_abnormal_blood-brain_barrier1.22063987
59MP0000689_abnormal_spleen_morphology1.21911630
60MP0002933_joint_inflammation1.20345635
61MP0008469_abnormal_protein_level1.18225594
62MP0002405_respiratory_system_inflammati1.18157572
63MP0002429_abnormal_blood_cell1.18020458
64MP0002722_abnormal_immune_system1.17783468
65MP0000604_amyloidosis1.14312072
66MP0003045_fibrosis1.13866789
67MP0003172_abnormal_lysosome_physiology1.13382372
68MP0009278_abnormal_bone_marrow1.13031315
69MP0001533_abnormal_skeleton_physiology1.12728986
70MP0004142_abnormal_muscle_tone1.11586930
71MP0005464_abnormal_platelet_physiology1.11355921
72MP0001879_abnormal_lymphatic_vessel1.10934173
73MP0000716_abnormal_immune_system1.10925023
74MP0008260_abnormal_autophagy1.10399754
75MP0001346_abnormal_lacrimal_gland1.10392604
76MP0001502_abnormal_circadian_rhythm1.09550317
77MP0000383_abnormal_hair_follicle1.09161695
78MP0004808_abnormal_hematopoietic_stem1.09155781
79MP0009333_abnormal_splenocyte_physiolog1.06885673
80MP0010155_abnormal_intestine_physiology1.05483192
81MP0003448_altered_tumor_morphology1.05351706
82MP0009780_abnormal_chondrocyte_physiolo1.04548264
83MP0003191_abnormal_cellular_cholesterol1.03790275
84MP0004381_abnormal_hair_follicle1.03578500
85MP0002166_altered_tumor_susceptibility1.03038311
86MP0004947_skin_inflammation1.02204966
87MP0003136_yellow_coat_color1.01057828
88MP0003866_abnormal_defecation1.00590412
89MP0003656_abnormal_erythrocyte_physiolo1.00485105
90MP0000703_abnormal_thymus_morphology1.00265523
91MP0003633_abnormal_nervous_system0.98162188
92MP0002006_tumorigenesis0.97919123
93MP0002009_preneoplasia0.94435668
94MP0003763_abnormal_thymus_physiology0.93666796
95MP0003183_abnormal_peptide_metabolism0.92916465
96MP0002398_abnormal_bone_marrow0.91419822
97MP0009765_abnormal_xenobiotic_induced0.90082833
98MP0001845_abnormal_inflammatory_respons0.89833475
99MP0002332_abnormal_exercise_endurance0.89082364
100MP0001188_hyperpigmentation0.88085647
101MP0000249_abnormal_blood_vessel0.87786782
102MP0005058_abnormal_lysosome_morphology0.87360394
103MP0002998_abnormal_bone_remodeling0.87350016
104MP0004883_abnormal_blood_vessel0.87089568
105MP0002822_catalepsy0.86885720
106MP0005390_skeleton_phenotype0.86458722
107MP0010352_gastrointestinal_tract_polyps0.86388037
108MP0004484_altered_response_of0.85329475
109MP0010678_abnormal_skin_adnexa0.85145867
110MP0003091_abnormal_cell_migration0.84989477
111MP0003631_nervous_system_phenotype0.84432470
112MP0002063_abnormal_learning/memory/cond0.82601654
113MP0001873_stomach_inflammation0.82051082
114MP0008874_decreased_physiological_sensi0.81346211
115MP0002229_neurodegeneration0.80239293
116MP0005164_abnormal_response_to0.80203916
117MP0002277_abnormal_respiratory_mucosa0.78987044
118MP0002572_abnormal_emotion/affect_behav0.78968464
119MP0005535_abnormal_body_temperature0.78739511
120MP0002735_abnormal_chemical_nociception0.77553127
121MP0000343_altered_response_to0.77110919
122MP0001986_abnormal_taste_sensitivity0.77059844
123MP0005174_abnormal_tail_pigmentation0.76382604
124MP0002734_abnormal_mechanical_nocicepti0.76290528
125MP0009763_increased_sensitivity_to0.75709414
126MP0003300_gastrointestinal_ulcer0.75687272
127MP0000465_gastrointestinal_hemorrhage0.73972580
128MP0001529_abnormal_vocalization0.73826794
129MP0002067_abnormal_sensory_capabilities0.73190144
130MP0001663_abnormal_digestive_system0.72694791
131MP0000858_altered_metastatic_potential0.71627801
132MP0003646_muscle_fatigue0.65704195
133MP0003221_abnormal_cardiomyocyte_apopto0.62746686
134MP0002132_abnormal_respiratory_system0.58350934
135MP0006054_spinal_hemorrhage0.57633010
136MP0002396_abnormal_hematopoietic_system0.53050825
137MP0008961_abnormal_basal_metabolism0.52535267
138MP0005451_abnormal_body_composition0.48682235

Predicted human phenotypes

RankGene SetZ-score
1Keratoconjunctivitis sicca (HP:0001097)4.35969548
2Neurofibrillary tangles (HP:0002185)4.27636803
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.16368306
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.16368306
5Parakeratosis (HP:0001036)4.08572709
6Keratoconjunctivitis (HP:0001096)4.06657491
7Peripheral hypomyelination (HP:0007182)3.90349568
8Hemoptysis (HP:0002105)3.66630154
9Gastrointestinal infarctions (HP:0005244)3.62775346
10Chronic otitis media (HP:0000389)3.57177028
11Stomatitis (HP:0010280)3.48424451
12White forelock (HP:0002211)3.35459040
13Gangrene (HP:0100758)3.32282186
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.25178858
15Elevated erythrocyte sedimentation rate (HP:0003565)3.24770628
16Onion bulb formation (HP:0003383)3.24325737
17Recurrent abscess formation (HP:0002722)3.16375175
18Eczematoid dermatitis (HP:0000976)3.15120469
19Encephalitis (HP:0002383)3.13880088
20Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.12393840
21Patchy hypopigmentation of hair (HP:0011365)3.09343959
22Chest pain (HP:0100749)3.09056236
23Gastrointestinal stroma tumor (HP:0100723)3.08239076
24Autoimmune hemolytic anemia (HP:0001890)3.00971423
25Arterial thrombosis (HP:0004420)2.99868567
26Recurrent bacterial skin infections (HP:0005406)2.99315381
27Supranuclear gaze palsy (HP:0000605)2.97743888
28Abnormality of macrophages (HP:0004311)2.94428701
29Recurrent skin infections (HP:0001581)2.94088654
30Slow saccadic eye movements (HP:0000514)2.88264723
31Sensory axonal neuropathy (HP:0003390)2.87490788
32Pulmonary embolism (HP:0002204)2.83789525
33Abnormality of the pleura (HP:0002103)2.82388256
34Abnormality of the corticospinal tract (HP:0002492)2.81043021
35Increased IgE level (HP:0003212)2.76153459
36Recurrent bronchitis (HP:0002837)2.69571478
37Dysmetria (HP:0001310)2.66827064
38Episodic fever (HP:0001954)2.64006984
39Retrobulbar optic neuritis (HP:0100654)2.63731137
40Optic neuritis (HP:0100653)2.63731137
41Cerebral hemorrhage (HP:0001342)2.60717693
42Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.58173607
43Hepatosplenomegaly (HP:0001433)2.57875366
44Scanning speech (HP:0002168)2.57434516
45Cerebral inclusion bodies (HP:0100314)2.56010580
46Intention tremor (HP:0002080)2.53396755
47Cellulitis (HP:0100658)2.53208121
48Agammaglobulinemia (HP:0004432)2.52406187
49Abnormality of T cells (HP:0002843)2.52266158
50Myositis (HP:0100614)2.51772722
51Vasculitis (HP:0002633)2.51333082
52Thickened helices (HP:0000391)2.50835798
53Recurrent fungal infections (HP:0002841)2.50398339
54Vertigo (HP:0002321)2.47769394
55Mediastinal lymphadenopathy (HP:0100721)2.47152792
56Pulmonary infiltrates (HP:0002113)2.46988555
57Urticaria (HP:0001025)2.46327252
58Abnormality of B cell number (HP:0010975)2.43047645
59Segmental peripheral demyelination/remyelination (HP:0003481)2.42398582
60Recurrent cutaneous fungal infections (HP:0011370)2.41389448
61Chronic mucocutaneous candidiasis (HP:0002728)2.41389448
62Hematochezia (HP:0002573)2.38712329
63Focal motor seizures (HP:0011153)2.37759593
64Anorexia (HP:0002039)2.37617389
65Eosinophilia (HP:0001880)2.37612918
66Nonprogressive disorder (HP:0003680)2.37159312
67Abnormality of the endocardium (HP:0004306)2.35641077
68Neoplasm of the tracheobronchial system (HP:0100552)2.33440752
69Abnormal hair whorl (HP:0010721)2.31659851
70Keratitis (HP:0000491)2.31439841
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.30207415
72Hemiplegia (HP:0002301)2.28375470
73Alveolar cell carcinoma (HP:0006519)2.28328157
74Sepsis (HP:0100806)2.26605922
75Orchitis (HP:0100796)2.26517451
76Panhypogammaglobulinemia (HP:0003139)2.23412610
77Subacute progressive viral hepatitis (HP:0006572)2.22906904
78Autoimmune thrombocytopenia (HP:0001973)2.22687559
79B lymphocytopenia (HP:0010976)2.22680270
80Gingivitis (HP:0000230)2.21820887
81IgG deficiency (HP:0004315)2.21168393
82Polyneuropathy (HP:0001271)2.20578717
83Axonal loss (HP:0003447)2.19565715
84Papilledema (HP:0001085)2.18961725
85Abnormal auditory evoked potentials (HP:0006958)2.18674709
86Lymphopenia (HP:0001888)2.15152508
87Xerostomia (HP:0000217)2.15069098
88Spastic gait (HP:0002064)2.15064868
89Widely spaced teeth (HP:0000687)2.14977231
90Glomerulopathy (HP:0100820)2.14872568
91Purpura (HP:0000979)2.10692895
92Granulocytopenia (HP:0001913)2.10595812
93Clumsiness (HP:0002312)2.09902511
94Restrictive lung disease (HP:0002091)2.09602268
95Amyloidosis (HP:0011034)2.08496118
96Abnormality of cells of the lymphoid lineage (HP:0012140)2.07848573
97Pustule (HP:0200039)2.06977731
98Inflammation of the large intestine (HP:0002037)2.06465445
99Myokymia (HP:0002411)2.06295575
100Abnormality of T cell number (HP:0011839)2.04115201
101Anhidrosis (HP:0000970)2.03109042
102Akinesia (HP:0002304)2.02942786
103Loss of speech (HP:0002371)2.02049917
104Progressive inability to walk (HP:0002505)2.01787979
105Spontaneous hematomas (HP:0007420)2.01748802
106Increased cerebral lipofuscin (HP:0011813)2.01747185
107Osteomyelitis (HP:0002754)2.01645202
108Hypoplasia of the iris (HP:0007676)2.00079112
109Disinhibition (HP:0000734)1.99761118
110Viral hepatitis (HP:0006562)1.99740029
111Premature skin wrinkling (HP:0100678)1.98845260
112Colitis (HP:0002583)1.98550257
113Depressed nasal tip (HP:0000437)1.98061659
114Abnormality of the prostate (HP:0008775)1.96933848
115Arthralgia (HP:0002829)1.96488538
116Recurrent viral infections (HP:0004429)1.95076867
117Weak cry (HP:0001612)1.94804742
118Epileptic encephalopathy (HP:0200134)1.94788240
119Joint swelling (HP:0001386)1.94739054
120Atonic seizures (HP:0010819)1.94474519
121Thyroiditis (HP:0100646)1.94118341
122Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93488898
123Meningitis (HP:0001287)1.92944904
124Abnormality of T cell physiology (HP:0011840)1.92794302
125Memory impairment (HP:0002354)1.92697163
126Abnormality of the pericardium (HP:0001697)1.91354096
127T lymphocytopenia (HP:0005403)1.90969823
128Abnormality of the peritoneum (HP:0002585)1.89803499
129Thick nail (HP:0001805)1.88939390
130Abnormality of eosinophils (HP:0001879)1.87878852
131Ankle clonus (HP:0011448)1.86523006
132Pulmonary artery stenosis (HP:0004415)1.86425899
133Obstructive lung disease (HP:0006536)1.85193673
134Chronic obstructive pulmonary disease (HP:0006510)1.85193673
135Amaurosis fugax (HP:0100576)1.85094544
136Severe combined immunodeficiency (HP:0004430)1.84533142
137Stomach cancer (HP:0012126)1.84425497
138Interstitial pulmonary disease (HP:0006530)1.84349535
139Autoamputation (HP:0001218)1.83337022
140Gastrointestinal inflammation (HP:0004386)1.82611806
141Difficulty running (HP:0009046)1.81352686
142Leukocytosis (HP:0001974)1.80664817
143Papilloma (HP:0012740)1.80283468
144Verrucae (HP:0200043)1.80283468
145Gaze-evoked nystagmus (HP:0000640)1.77849927
146Hypergammaglobulinemia (HP:0010702)1.76348999
147Increased IgM level (HP:0003496)1.75753362
148Conical tooth (HP:0000698)1.75277330
149Alacrima (HP:0000522)1.74695460
150Recurrent pneumonia (HP:0006532)1.74369212
151Abnormality of the periventricular white matter (HP:0002518)1.73732601
152Poor speech (HP:0002465)1.73606344
153Submucous cleft hard palate (HP:0000176)1.72566728
154Broad-based gait (HP:0002136)1.72472672
155Lower limb muscle weakness (HP:0007340)1.71596796
156Gingival bleeding (HP:0000225)1.71355433
157Fatigue (HP:0012378)1.71240011
158Abnormality of the columella (HP:0009929)1.70637698
159Diplopia (HP:0000651)1.68700953
160Abnormality of binocular vision (HP:0011514)1.68700953
161Recurrent gram-negative bacterial infections (HP:0005420)1.68434383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB13.61994657
2STK393.43161607
3MAP3K143.02385431
4TNIK2.95590078
5OXSR12.73316574
6RIPK42.33956339
7CDK192.25024919
8MAP3K132.22862275
9IKBKE1.95542289
10PKN11.92226753
11TAOK31.92124286
12TBK11.90061442
13MUSK1.89876005
14IKBKB1.81130869
15MAPKAPK51.80921055
16NEK61.80603162
17IRAK41.73122446
18KIT1.65600936
19TXK1.58593915
20ZAP701.57357355
21PRPF4B1.54585978
22MST41.53308950
23PDK21.49841420
24SIK31.49799429
25FES1.42221148
26CASK1.40888348
27MAP4K11.40185381
28MAP2K31.38414397
29TIE11.37154234
30BCR1.33519639
31FGR1.25981028
32PBK1.25390618
33NLK1.21059312
34RIPK11.19949861
35CLK11.18955659
36BMPR1B1.17932731
37BMPR21.16838452
38EPHA31.11589161
39MAP3K31.10773379
40JAK31.10388594
41WNK11.08184637
42FGFR21.06918733
43ITK1.05385389
44TNK21.04584163
45TYK21.04114093
46GRK71.03682670
47IRAK10.99582078
48GRK60.98472164
49MAPK150.96410307
50ADRBK20.95053473
51JAK10.93968935
52PRKCH0.92266359
53TEC0.90304026
54LCK0.89798917
55MET0.88508302
56MAPK120.88187065
57PRKCQ0.87970358
58CSF1R0.87810525
59CSK0.87517764
60SGK20.87233425
61TAOK10.86089725
62EPHA40.85689023
63MAP3K120.85175848
64ERN10.83263586
65NTRK10.80015667
66MAPK70.79923607
67UHMK10.79729369
68CAMK2B0.79249606
69FGFR30.78310625
70BTK0.78078817
71SIK20.77380063
72TAOK20.75807108
73CHUK0.75627857
74MATK0.75347115
75BLK0.75156235
76PRKCE0.74875254
77HIPK20.72687087
78SGK4940.72466711
79SGK2230.72466711
80TRPM70.71818283
81SYK0.71585733
82HCK0.71543362
83CAMK2D0.71369031
84PRKD20.71285608
85CSNK1A1L0.70283310
86WNK40.69774367
87MARK30.68889371
88ROCK20.67578063
89FYN0.66062028
90CDK50.63763613
91CSNK1G30.62213840
92SGK30.61646432
93PDPK10.61602437
94TYRO30.61296388
95TGFBR20.60141880
96PIK3CG0.59796329
97MAP3K50.58722350
98PDK10.57838481
99IRAK30.57380604
100PIM10.57082067
101JAK20.56436369
102RPS6KA50.56015211
103MAP3K110.55828404
104CAMKK20.54844838
105MAPK40.53791016
106NTRK20.53750241
107STK110.53139555
108BMX0.52682873
109CAMKK10.52366617
110BRD40.52043619
111MAP3K10.51991270
112DMPK0.51923816
113MARK20.51917326
114CAMK2G0.51749268
115KSR20.51170074
116LYN0.51163775
117STK100.51052143
118PTK2B0.49911461
119YES10.49665968
120IRAK20.49520026
121CAMK40.49060199
122CAMK2A0.48387741
123CDC42BPA0.48356816
124MAP2K20.47877579
125DYRK1A0.47671705
126PDGFRB0.47442989
127ABL10.47211135
128PAK60.46493397
129FGFR40.45492199
130CSNK1G10.44415553
131NUAK10.43856545
132MAP3K70.43527046
133MOS0.42702941
134DAPK20.42149177
135NTRK30.40193616
136EGFR0.40030511
137STK380.38072708
138ERBB30.36972165
139MARK10.35673242
140DYRK1B0.31669283

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051442.03164940
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91988120
3Allograft rejection_Homo sapiens_hsa053301.90795664
4Graft-versus-host disease_Homo sapiens_hsa053321.87399084
5Leishmaniasis_Homo sapiens_hsa051401.85218621
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.85159049
7Rheumatoid arthritis_Homo sapiens_hsa053231.84062752
8NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76648834
9Osteoclast differentiation_Homo sapiens_hsa043801.71086279
10African trypanosomiasis_Homo sapiens_hsa051431.69899153
11B cell receptor signaling pathway_Homo sapiens_hsa046621.65651583
12Ether lipid metabolism_Homo sapiens_hsa005651.50664270
13Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.48511921
14Chemokine signaling pathway_Homo sapiens_hsa040621.46281060
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45318707
16Viral myocarditis_Homo sapiens_hsa054161.42944016
17TNF signaling pathway_Homo sapiens_hsa046681.41122755
18Primary immunodeficiency_Homo sapiens_hsa053401.39907220
19Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.39136259
20Pertussis_Homo sapiens_hsa051331.38871052
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.37464572
22Autoimmune thyroid disease_Homo sapiens_hsa053201.32052056
23Fatty acid elongation_Homo sapiens_hsa000621.28972030
24Hematopoietic cell lineage_Homo sapiens_hsa046401.28378225
25Herpes simplex infection_Homo sapiens_hsa051681.27814477
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.27631891
27Antigen processing and presentation_Homo sapiens_hsa046121.26878475
28T cell receptor signaling pathway_Homo sapiens_hsa046601.26040653
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24269702
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23725305
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22914888
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21122540
33Type I diabetes mellitus_Homo sapiens_hsa049401.19552274
34Salmonella infection_Homo sapiens_hsa051321.19201954
35* Morphine addiction_Homo sapiens_hsa050321.15122711
36Asthma_Homo sapiens_hsa053101.15055451
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13817664
38Measles_Homo sapiens_hsa051621.12929371
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.12757504
40Glutamatergic synapse_Homo sapiens_hsa047241.11703281
41Sphingolipid metabolism_Homo sapiens_hsa006001.11281708
42Dorso-ventral axis formation_Homo sapiens_hsa043201.08985418
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08580488
44GABAergic synapse_Homo sapiens_hsa047271.07759215
45Sphingolipid signaling pathway_Homo sapiens_hsa040711.05135954
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03827463
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03333650
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01832938
49Steroid biosynthesis_Homo sapiens_hsa001001.01826846
50Axon guidance_Homo sapiens_hsa043600.98713767
51Serotonergic synapse_Homo sapiens_hsa047260.98706496
52Cocaine addiction_Homo sapiens_hsa050300.98524616
53Tuberculosis_Homo sapiens_hsa051520.97659186
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96940790
55Toxoplasmosis_Homo sapiens_hsa051450.96904120
56Circadian entrainment_Homo sapiens_hsa047130.91523509
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.90981410
58Platelet activation_Homo sapiens_hsa046110.89529160
59MAPK signaling pathway_Homo sapiens_hsa040100.88516902
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.86479844
61Long-term depression_Homo sapiens_hsa047300.85996011
62Shigellosis_Homo sapiens_hsa051310.85750267
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84837068
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84344977
65Renal cell carcinoma_Homo sapiens_hsa052110.83935089
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.83401264
67Cholinergic synapse_Homo sapiens_hsa047250.82247836
68Renin secretion_Homo sapiens_hsa049240.80799018
69Ras signaling pathway_Homo sapiens_hsa040140.80152442
70VEGF signaling pathway_Homo sapiens_hsa043700.79286710
71FoxO signaling pathway_Homo sapiens_hsa040680.78436331
72Type II diabetes mellitus_Homo sapiens_hsa049300.78076835
73Salivary secretion_Homo sapiens_hsa049700.77056978
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76712161
75Endocytosis_Homo sapiens_hsa041440.75894207
76Phagosome_Homo sapiens_hsa041450.75499947
77Legionellosis_Homo sapiens_hsa051340.74111088
78Olfactory transduction_Homo sapiens_hsa047400.73382630
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.72305135
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71223757
81Nicotine addiction_Homo sapiens_hsa050330.68803492
82Influenza A_Homo sapiens_hsa051640.68330884
83Lysosome_Homo sapiens_hsa041420.68313310
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67760794
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.66771712
86Gastric acid secretion_Homo sapiens_hsa049710.65573507
87Hepatitis C_Homo sapiens_hsa051600.65371581
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64624330
89ErbB signaling pathway_Homo sapiens_hsa040120.64369251
90Epstein-Barr virus infection_Homo sapiens_hsa051690.63700981
91Acute myeloid leukemia_Homo sapiens_hsa052210.62978195
92Pancreatic cancer_Homo sapiens_hsa052120.62402214
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62392054
94Non-small cell lung cancer_Homo sapiens_hsa052230.62016333
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60982968
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60240018
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59625721
98Oxytocin signaling pathway_Homo sapiens_hsa049210.59522503
99Chronic myeloid leukemia_Homo sapiens_hsa052200.58472405
100Staphylococcus aureus infection_Homo sapiens_hsa051500.58400211
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57933486
102* cAMP signaling pathway_Homo sapiens_hsa040240.57923482
103Calcium signaling pathway_Homo sapiens_hsa040200.56998174
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56918342
105GnRH signaling pathway_Homo sapiens_hsa049120.56412284
106Choline metabolism in cancer_Homo sapiens_hsa052310.55230836
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54905486
108Inositol phosphate metabolism_Homo sapiens_hsa005620.54546468
109Amoebiasis_Homo sapiens_hsa051460.54454436
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53347741
111Prolactin signaling pathway_Homo sapiens_hsa049170.53014176
112Endometrial cancer_Homo sapiens_hsa052130.51334904
113HIF-1 signaling pathway_Homo sapiens_hsa040660.51271958
114HTLV-I infection_Homo sapiens_hsa051660.50791774
115Hepatitis B_Homo sapiens_hsa051610.50447007
116Apoptosis_Homo sapiens_hsa042100.50048426
117Insulin resistance_Homo sapiens_hsa049310.49813314
118Notch signaling pathway_Homo sapiens_hsa043300.48979693
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48397042
120Amphetamine addiction_Homo sapiens_hsa050310.48083667
121Colorectal cancer_Homo sapiens_hsa052100.47768643
122Long-term potentiation_Homo sapiens_hsa047200.47442736
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46615668
124Estrogen signaling pathway_Homo sapiens_hsa049150.45417205
125Circadian rhythm_Homo sapiens_hsa047100.45297613
126Viral carcinogenesis_Homo sapiens_hsa052030.43013586
127mTOR signaling pathway_Homo sapiens_hsa041500.41796601
128Prion diseases_Homo sapiens_hsa050200.41744967
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39013345
130Rap1 signaling pathway_Homo sapiens_hsa040150.37358836
131Other glycan degradation_Homo sapiens_hsa005110.33386822

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