PDE4C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.03539533
2L-phenylalanine catabolic process (GO:0006559)7.03539533
3indole-containing compound catabolic process (GO:0042436)6.95827254
4indolalkylamine catabolic process (GO:0046218)6.95827254
5tryptophan catabolic process (GO:0006569)6.95827254
6aromatic amino acid family catabolic process (GO:0009074)6.94445072
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.69826931
8L-phenylalanine metabolic process (GO:0006558)6.69826931
9tryptophan metabolic process (GO:0006568)6.55480542
10glyoxylate metabolic process (GO:0046487)6.17591989
11kynurenine metabolic process (GO:0070189)5.94137175
12drug transmembrane transport (GO:0006855)5.93439604
13urate metabolic process (GO:0046415)5.87010981
14behavioral response to nicotine (GO:0035095)5.78512102
15cysteine metabolic process (GO:0006534)5.25808806
16lysine catabolic process (GO:0006554)5.22767685
17lysine metabolic process (GO:0006553)5.22767685
18bile acid biosynthetic process (GO:0006699)5.22178923
19serine family amino acid catabolic process (GO:0009071)5.20758555
20cellular biogenic amine catabolic process (GO:0042402)5.14802254
21amine catabolic process (GO:0009310)5.14802254
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.14759326
23indolalkylamine metabolic process (GO:0006586)5.10009092
24aromatic amino acid family metabolic process (GO:0009072)5.05845225
25L-fucose catabolic process (GO:0042355)4.96902316
26fucose catabolic process (GO:0019317)4.96902316
27L-fucose metabolic process (GO:0042354)4.96902316
28amino-acid betaine metabolic process (GO:0006577)4.96875515
29homocysteine metabolic process (GO:0050667)4.96046637
30drug transport (GO:0015893)4.83654280
31drug catabolic process (GO:0042737)4.76701278
32alpha-amino acid catabolic process (GO:1901606)4.65535941
33DNA deamination (GO:0045006)4.60506658
34urea cycle (GO:0000050)4.48277800
35urea metabolic process (GO:0019627)4.48277800
36triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.37999444
37bile acid metabolic process (GO:0008206)4.36233844
38response to pheromone (GO:0019236)4.35292548
39cellular glucuronidation (GO:0052695)4.33228147
40exogenous drug catabolic process (GO:0042738)4.27398588
41short-chain fatty acid metabolic process (GO:0046459)4.25515719
42cellular amino acid catabolic process (GO:0009063)4.25071975
43benzene-containing compound metabolic process (GO:0042537)4.24311737
44tyrosine metabolic process (GO:0006570)4.23985504
45sulfur amino acid catabolic process (GO:0000098)4.23348046
46NAD biosynthetic process (GO:0009435)4.23300504
47nitrogen cycle metabolic process (GO:0071941)4.14758164
48aldehyde catabolic process (GO:0046185)4.13127746
49regulation of cholesterol esterification (GO:0010872)4.13081571
50serine family amino acid metabolic process (GO:0009069)4.07445080
51uronic acid metabolic process (GO:0006063)4.06624812
52glucuronate metabolic process (GO:0019585)4.06624812
53gamma-aminobutyric acid transport (GO:0015812)4.04213627
54cellular ketone body metabolic process (GO:0046950)4.03981233
55cellular modified amino acid catabolic process (GO:0042219)3.99949905
56glutamate metabolic process (GO:0006536)3.99670896
57regulation of fibrinolysis (GO:0051917)3.98910302
58peptidyl-glutamic acid carboxylation (GO:0017187)3.98365699
59protein carboxylation (GO:0018214)3.98365699
60imidazole-containing compound metabolic process (GO:0052803)3.95512111
61organic cation transport (GO:0015695)3.92062734
62regulation of bile acid biosynthetic process (GO:0070857)3.90381543
63high-density lipoprotein particle remodeling (GO:0034375)3.90157614
64carnitine metabolic process (GO:0009437)3.88076022
65regulation of protein activation cascade (GO:2000257)3.86554506
66carboxylic acid catabolic process (GO:0046395)3.82644199
67organic acid catabolic process (GO:0016054)3.82644199
68triglyceride homeostasis (GO:0070328)3.82098660
69acylglycerol homeostasis (GO:0055090)3.82098660
70nicotinamide nucleotide biosynthetic process (GO:0019359)3.80881914
71pyridine nucleotide biosynthetic process (GO:0019363)3.80881914
72indole-containing compound metabolic process (GO:0042430)3.79549607
73coenzyme catabolic process (GO:0009109)3.77453790
74complement activation, alternative pathway (GO:0006957)3.76375246
75fatty acid beta-oxidation (GO:0006635)3.74564590
76alpha-linolenic acid metabolic process (GO:0036109)3.73695915
77negative regulation of fibrinolysis (GO:0051918)3.72556443
78water-soluble vitamin biosynthetic process (GO:0042364)3.70268817
79aspartate family amino acid catabolic process (GO:0009068)3.65070852
80fatty acid oxidation (GO:0019395)3.64476016
81lipid oxidation (GO:0034440)3.59671870
82branched-chain amino acid metabolic process (GO:0009081)3.59370916
83regulation of triglyceride catabolic process (GO:0010896)3.58911901
84glycine metabolic process (GO:0006544)3.58615639
85valine metabolic process (GO:0006573)3.57566133
86branched-chain amino acid catabolic process (GO:0009083)3.55944568
87regulation of complement activation (GO:0030449)3.55161608
88serine family amino acid biosynthetic process (GO:0009070)3.55051264
89monocarboxylic acid catabolic process (GO:0072329)3.54850683
90arginine metabolic process (GO:0006525)3.52776044
91bile acid and bile salt transport (GO:0015721)3.52503695
92dicarboxylic acid biosynthetic process (GO:0043650)3.52270211
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51397232
94acetyl-CoA metabolic process (GO:0006084)3.51020396
95response to mercury ion (GO:0046689)3.50619522
96aminoglycoside antibiotic metabolic process (GO:0030647)3.50065892
97negative regulation of cholesterol transport (GO:0032375)3.46183561
98negative regulation of sterol transport (GO:0032372)3.46183561
99ketone body metabolic process (GO:1902224)3.43876965
100plasma lipoprotein particle remodeling (GO:0034369)3.43012521
101protein-lipid complex remodeling (GO:0034368)3.43012521
102macromolecular complex remodeling (GO:0034367)3.43012521
103reverse cholesterol transport (GO:0043691)3.40516639
104fatty acid catabolic process (GO:0009062)3.40278489
105pyrimidine nucleoside catabolic process (GO:0046135)3.40024997
106regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.38630290
107phosphate ion transport (GO:0006817)3.37366464
1082-oxoglutarate metabolic process (GO:0006103)3.36820645
109detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.36281288
110ethanol oxidation (GO:0006069)3.32607510
111small molecule catabolic process (GO:0044282)3.27206923
112negative regulation of telomere maintenance (GO:0032205)3.25549109
113nephron epithelium morphogenesis (GO:0072088)3.23777476
114nephron tubule morphogenesis (GO:0072078)3.23777476
115platelet dense granule organization (GO:0060155)3.23360630
116protein complex biogenesis (GO:0070271)3.21813753
117mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17695472
118mitochondrial respiratory chain complex I assembly (GO:0032981)3.17695472
119NADH dehydrogenase complex assembly (GO:0010257)3.17695472
120axoneme assembly (GO:0035082)3.09098196
121negative regulation of mast cell activation (GO:0033004)3.04276440
122epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02708543
123protein polyglutamylation (GO:0018095)3.01582728
124detection of light stimulus involved in sensory perception (GO:0050962)3.00861521
125detection of light stimulus involved in visual perception (GO:0050908)3.00861521
126mitochondrial respiratory chain complex assembly (GO:0033108)3.00571455
127neuronal action potential (GO:0019228)2.97616202
128protein-cofactor linkage (GO:0018065)2.94306646
129sulfation (GO:0051923)2.93577947
130respiratory chain complex IV assembly (GO:0008535)2.91251935
131regulation of cilium movement (GO:0003352)2.90319420
132synaptic transmission, cholinergic (GO:0007271)2.89397416
133epithelial cilium movement (GO:0003351)2.88516122
134protein K11-linked deubiquitination (GO:0035871)2.85298932
135fucosylation (GO:0036065)2.83956685
136piRNA metabolic process (GO:0034587)2.83055561
137regulation of action potential (GO:0098900)2.81349505
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.80998054
139primary amino compound metabolic process (GO:1901160)2.76946865
140ubiquinone biosynthetic process (GO:0006744)2.76890021
141cellular response to ATP (GO:0071318)2.72692760
142multicellular organism reproduction (GO:0032504)2.71953536
143kidney morphogenesis (GO:0060993)2.69868667
144regulation of mesoderm development (GO:2000380)2.69755098
145retinal cone cell development (GO:0046549)2.68907844
146rRNA catabolic process (GO:0016075)2.68338456
147alanine transport (GO:0032328)2.67891564
148behavioral response to ethanol (GO:0048149)2.67446470
149proline transport (GO:0015824)2.66466488
150regulation of hexokinase activity (GO:1903299)2.63383316
151regulation of glucokinase activity (GO:0033131)2.63383316
152cytochrome complex assembly (GO:0017004)2.62945547
153membrane depolarization during action potential (GO:0086010)2.62764226
154mannosylation (GO:0097502)2.62492523
155renal tubule morphogenesis (GO:0061333)2.60776852
156reciprocal DNA recombination (GO:0035825)2.57321536
157reciprocal meiotic recombination (GO:0007131)2.57321536
158ubiquinone metabolic process (GO:0006743)2.57069420
159preassembly of GPI anchor in ER membrane (GO:0016254)2.56222411
160protein localization to cilium (GO:0061512)2.56192166
161positive regulation of fatty acid transport (GO:2000193)2.55839299
162L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55160800
163spinal cord motor neuron differentiation (GO:0021522)2.54335564
164nonmotile primary cilium assembly (GO:0035058)2.53666945
165negative regulation of cytosolic calcium ion concentration (GO:0051481)2.53522353
166photoreceptor cell development (GO:0042461)2.53364541
167sperm motility (GO:0030317)2.53282745
168regulation of rhodopsin mediated signaling pathway (GO:0022400)2.52902546
169auditory receptor cell stereocilium organization (GO:0060088)2.52735088
170energy coupled proton transport, down electrochemical gradient (GO:0015985)2.52673091
171ATP synthesis coupled proton transport (GO:0015986)2.52673091
172transepithelial transport (GO:0070633)2.52272036
173male meiosis I (GO:0007141)2.50094954
174negative regulation of reactive oxygen species metabolic process (GO:2000378)2.49610780
175dopamine transport (GO:0015872)2.47143779
176cilium morphogenesis (GO:0060271)2.46978922
177G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46639528
178positive regulation of triglyceride biosynthetic process (GO:0010867)2.46380057
179cilium movement (GO:0003341)2.46262118
180mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.45811615
181reflex (GO:0060004)2.45537302
182rhodopsin mediated signaling pathway (GO:0016056)2.43876018
183basic amino acid transport (GO:0015802)2.41154511
184action potential (GO:0001508)2.40666717
185photoreceptor cell maintenance (GO:0045494)2.39572983
186L-methionine biosynthetic process (GO:0071265)2.38810591

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.08009140
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.75574427
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.60310067
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.57384629
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.14575053
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.41906164
7ZNF274_21170338_ChIP-Seq_K562_Hela4.13635301
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.08893121
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.41658406
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.31971993
11EZH2_22144423_ChIP-Seq_EOC_Human2.97989930
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.60422678
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07474963
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02406986
15IGF1R_20145208_ChIP-Seq_DFB_Human1.92667149
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85522660
17FUS_26573619_Chip-Seq_HEK293_Human1.81420767
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79608714
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74889460
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73322396
21EWS_26573619_Chip-Seq_HEK293_Human1.71585859
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70669971
23ER_23166858_ChIP-Seq_MCF-7_Human1.68471562
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65160665
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64603776
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62557536
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61632051
28REST_21632747_ChIP-Seq_MESCs_Mouse1.56730213
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.54615905
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52610553
31TP53_22573176_ChIP-Seq_HFKS_Human1.52536026
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52523785
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.50141552
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49264270
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49016932
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48500855
37CBP_20019798_ChIP-Seq_JUKART_Human1.48500855
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.48094725
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.47419285
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47419285
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43775197
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42507912
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41837661
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41837661
45GBX2_23144817_ChIP-Seq_PC3_Human1.41626565
46KAP1_22055183_ChIP-Seq_ESCs_Mouse1.41359275
47* AR_25329375_ChIP-Seq_VCAP_Human1.40574139
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.39145793
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38149619
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37672549
51* GATA3_21878914_ChIP-Seq_MCF-7_Human1.37281669
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.37057814
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.36684478
54SOX2_19829295_ChIP-Seq_ESCs_Human1.36544715
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35042312
56STAT3_23295773_ChIP-Seq_U87_Human1.34889573
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34603690
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34515161
59HTT_18923047_ChIP-ChIP_STHdh_Human1.32371784
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29396763
61TCF4_23295773_ChIP-Seq_U87_Human1.29338727
62DROSHA_22980978_ChIP-Seq_HELA_Human1.29292976
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29292217
64HNF4A_19822575_ChIP-Seq_HepG2_Human1.28771346
65FOXA2_19822575_ChIP-Seq_HepG2_Human1.27091722
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27081746
67TCF4_22108803_ChIP-Seq_LS180_Human1.26058593
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23582703
69SMAD4_21799915_ChIP-Seq_A2780_Human1.23331767
70MYC_18940864_ChIP-ChIP_HL60_Human1.23093574
71HOXB7_26014856_ChIP-Seq_BT474_Human1.22674663
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.22036750
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20354962
74RUNX2_22187159_ChIP-Seq_PCA_Human1.19904191
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.19816881
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.18880417
77NCOR_22424771_ChIP-Seq_293T_Human1.18368678
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17827723
79AR_21572438_ChIP-Seq_LNCaP_Human1.17515369
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17515044
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17094864
82ERA_21632823_ChIP-Seq_H3396_Human1.17065850
83RNF2_27304074_Chip-Seq_NSC_Mouse1.16506245
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.15699670
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14957875
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14557241
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.13591787
88MYC_19829295_ChIP-Seq_ESCs_Human1.13571468
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13510881
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12615509
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12339625
92RUNX1_27457419_Chip-Seq_LIVER_Mouse1.11758807
93TAF2_19829295_ChIP-Seq_ESCs_Human1.11493361
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.11404720
95CRX_20693478_ChIP-Seq_RETINA_Mouse1.09801570
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08760819
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08617617
98JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08497117
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.07957814
100EED_16625203_ChIP-ChIP_MESCs_Mouse1.04057005
101REST_18959480_ChIP-ChIP_MESCs_Mouse1.03920258
102PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03723348
103NANOG_20526341_ChIP-Seq_ESCs_Human1.03486147
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.02995801
105ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02961181
106CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02874606
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01740282
108OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01595511
109EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01419089
110STAT1_17558387_ChIP-Seq_HELA_Human1.01067409
111P53_21459846_ChIP-Seq_SAOS-2_Human1.00479596
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00352577
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.00049295
114SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99987720
115OCT4_18555785_Chip-Seq_ESCs_Mouse0.99979411
116P53_22387025_ChIP-Seq_ESCs_Mouse0.99838908
117GABP_17652178_ChIP-ChIP_JURKAT_Human0.99722982
118RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99695573
119STAT3_18555785_Chip-Seq_ESCs_Mouse0.99458754
120TAF15_26573619_Chip-Seq_HEK293_Human0.99193586
121ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98905298
122SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98246945
123VDR_22108803_ChIP-Seq_LS180_Human0.97913593
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97829093
125JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97039874
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97020931
127EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96778380
128OCT4_20526341_ChIP-Seq_ESCs_Human0.96045317
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94429635
130ZFX_18555785_Chip-Seq_ESCs_Mouse0.91933293
131P300_18555785_Chip-Seq_ESCs_Mouse0.91770633
132NMYC_18555785_Chip-Seq_ESCs_Mouse0.90818332
133PU1_27457419_Chip-Seq_LIVER_Mouse0.90812719
134FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89309388
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.87692356
136SMAD1_18555785_Chip-Seq_ESCs_Mouse0.87546658
137E2F1_18555785_Chip-Seq_ESCs_Mouse0.87133669
138LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85348152
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84925986
140SOX2_18555785_Chip-Seq_ESCs_Mouse0.84283386
141GATA1_22025678_ChIP-Seq_K562_Human0.83884815
142KLF4_18555785_Chip-Seq_ESCs_Mouse0.83287300
143BCAT_22108803_ChIP-Seq_LS180_Human0.83285846
144GATA4_25053715_ChIP-Seq_YYC3_Human0.81290508
145AR_20517297_ChIP-Seq_VCAP_Human0.80784794
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79849763
147POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79527784
148TAL1_26923725_Chip-Seq_HPCs_Mouse0.78732318
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78725540
150IRF1_19129219_ChIP-ChIP_H3396_Human0.78713443
151AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77914966
152CTCF_18555785_Chip-Seq_ESCs_Mouse0.76881236
153CMYC_18555785_Chip-Seq_ESCs_Mouse0.76030652
154NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75341989
155NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75341989
156* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74422320
157* CDX2_22108803_ChIP-Seq_LS180_Human0.73430844
158PHF8_20622853_ChIP-Seq_HELA_Human0.71788206
159P300_19829295_ChIP-Seq_ESCs_Human0.71150811
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70692900
161AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.69593318
162EGR1_19032775_ChIP-ChIP_M12_Human0.68669709
163HNFA_21074721_ChIP-Seq_CACO-2_Human0.68621708
164CDX2_20551321_ChIP-Seq_CACO-2_Human0.68075685
165GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.67950137
166FOXH1_21741376_ChIP-Seq_EPCs_Human0.67172965
167* ESET_19884257_ChIP-Seq_ESCs_Mouse0.66495130
168KDM2B_26808549_Chip-Seq_REH_Human0.65894150
169SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.65293038
170PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.63885138
171MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.62422019
172GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.62224680
173NANOG_19829295_ChIP-Seq_ESCs_Human0.61794947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.50433630
2MP0002139_abnormal_hepatobiliary_system7.19298742
3MP0005085_abnormal_gallbladder_physiolo5.59232117
4MP0005365_abnormal_bile_salt5.27417685
5MP0008875_abnormal_xenobiotic_pharmacok4.53315033
6MP0003195_calcinosis4.23560759
7MP0003252_abnormal_bile_duct3.89810286
8MP0003283_abnormal_digestive_organ3.70005649
9MP0005332_abnormal_amino_acid3.62786947
10MP0004019_abnormal_vitamin_homeostasis3.39798880
11MP0002138_abnormal_hepatobiliary_system3.37682236
12MP0003806_abnormal_nucleotide_metabolis3.22471355
13MP0010329_abnormal_lipoprotein_level2.56006010
14MP0001968_abnormal_touch/_nociception2.45911787
15MP0005551_abnormal_eye_electrophysiolog2.40091414
16MP0002102_abnormal_ear_morphology2.39470076
17MP0004043_abnormal_pH_regulation2.37080894
18MP0008877_abnormal_DNA_methylation2.36395485
19MP0009643_abnormal_urine_homeostasis2.16398456
20MP0002876_abnormal_thyroid_physiology2.00308410
21MP0009745_abnormal_behavioral_response1.98106205
22MP0001666_abnormal_nutrient_absorption1.95641747
23MP0001764_abnormal_homeostasis1.93496772
24MP0001501_abnormal_sleep_pattern1.92218123
25MP0002736_abnormal_nociception_after1.89123334
26MP0005083_abnormal_biliary_tract1.88808510
27MP0009046_muscle_twitch1.88620660
28MP0002837_dystrophic_cardiac_calcinosis1.82820820
29MP0002272_abnormal_nervous_system1.77090687
30MP0001485_abnormal_pinna_reflex1.76988764
31MP0009697_abnormal_copulation1.76059944
32MP0002118_abnormal_lipid_homeostasis1.71169098
33MP0005636_abnormal_mineral_homeostasis1.70946640
34MP0004885_abnormal_endolymph1.70550977
35MP0004142_abnormal_muscle_tone1.67617868
36MP0006072_abnormal_retinal_apoptosis1.67207593
37MP0004133_heterotaxia1.65971554
38MP0009840_abnormal_foam_cell1.65942182
39MP0005319_abnormal_enzyme/_coenzyme1.64875274
40MP0005451_abnormal_body_composition1.63759946
41MP0002735_abnormal_chemical_nociception1.63360474
42MP0003880_abnormal_central_pattern1.63290792
43MP0000609_abnormal_liver_physiology1.62418772
44MP0005645_abnormal_hypothalamus_physiol1.58596294
45MP0003186_abnormal_redox_activity1.56406781
46MP0002638_abnormal_pupillary_reflex1.56165045
47MP0009764_decreased_sensitivity_to1.55140353
48MP0005584_abnormal_enzyme/coenzyme_acti1.54866447
49MP0000569_abnormal_digit_pigmentation1.53517926
50MP0005253_abnormal_eye_physiology1.51985879
51MP0000631_abnormal_neuroendocrine_gland1.49620409
52MP0002733_abnormal_thermal_nociception1.46638916
53MP0002938_white_spotting1.45404099
54MP0005410_abnormal_fertilization1.44208352
55MP0006276_abnormal_autonomic_nervous1.42404686
56MP0005647_abnormal_sex_gland1.39436214
57MP0005084_abnormal_gallbladder_morpholo1.39176352
58MP0002653_abnormal_ependyma_morphology1.38965157
59MP0003868_abnormal_feces_composition1.38826993
60MP0001756_abnormal_urination1.38671830
61MP0001970_abnormal_pain_threshold1.37725001
62MP0002064_seizures1.37353915
63MP0004145_abnormal_muscle_electrophysio1.36280277
64MP0002572_abnormal_emotion/affect_behav1.35697255
65MP0002136_abnormal_kidney_physiology1.35411386
66MP0001486_abnormal_startle_reflex1.32103216
67MP0003191_abnormal_cellular_cholesterol1.31034998
68MP0005670_abnormal_white_adipose1.30236251
69MP0002557_abnormal_social/conspecific_i1.28846881
70MP0001765_abnormal_ion_homeostasis1.28028180
71MP0003787_abnormal_imprinting1.25797017
72MP0001905_abnormal_dopamine_level1.23506533
73MP0002909_abnormal_adrenal_gland1.23268627
74MP0000427_abnormal_hair_cycle1.23187364
75MP0004742_abnormal_vestibular_system1.20953307
76MP0003724_increased_susceptibility_to1.18621259
77MP0005174_abnormal_tail_pigmentation1.16433396
78MP0002734_abnormal_mechanical_nocicepti1.12111693
79MP0001529_abnormal_vocalization1.10680567
80MP0002234_abnormal_pharynx_morphology1.09803588
81MP0002254_reproductive_system_inflammat1.09093707
82MP0004924_abnormal_behavior1.08434961
83MP0005386_behavior/neurological_phenoty1.08434961
84MP0008775_abnormal_heart_ventricle1.07420227
85MP0002928_abnormal_bile_duct1.06581554
86MP0005423_abnormal_somatic_nervous1.05973868
87MP0002067_abnormal_sensory_capabilities1.05970564
88MP0003119_abnormal_digestive_system1.05664851
89MP0002160_abnormal_reproductive_system1.05455501
90MP0002751_abnormal_autonomic_nervous1.04881629
91MP0001984_abnormal_olfaction1.04634706
92MP0005167_abnormal_blood-brain_barrier1.04286822
93MP0002063_abnormal_learning/memory/cond1.04107770
94MP0003635_abnormal_synaptic_transmissio1.03486294
95MP0004215_abnormal_myocardial_fiber1.00061731
96MP0005389_reproductive_system_phenotype0.98995192
97MP0005195_abnormal_posterior_eye0.98427953
98MP0003137_abnormal_impulse_conducting0.97683043
99MP0008469_abnormal_protein_level0.96056754
100MP0009642_abnormal_blood_homeostasis0.93700450
101MP0003698_abnormal_male_reproductive0.90843600
102MP0000566_synostosis0.90497566
103MP0006036_abnormal_mitochondrial_physio0.89905829
104MP0004085_abnormal_heartbeat0.89671614
105MP0002229_neurodegeneration0.88734195
106MP0005408_hypopigmentation0.88478581
107MP0000372_irregular_coat_pigmentation0.87718349
108MP0003122_maternal_imprinting0.87567751
109MP0000538_abnormal_urinary_bladder0.87554888
110MP0000026_abnormal_inner_ear0.85648131
111MP0009763_increased_sensitivity_to0.85283713
112MP0003878_abnormal_ear_physiology0.85000217
113MP0005377_hearing/vestibular/ear_phenot0.85000217
114MP0002752_abnormal_somatic_nervous0.83496080
115MP0000049_abnormal_middle_ear0.83371788
116MP0000598_abnormal_liver_morphology0.83132429
117MP0003011_delayed_dark_adaptation0.82944173
118MP0002184_abnormal_innervation0.80007826
119MP0001324_abnormal_eye_pigmentation0.79790294
120MP0001963_abnormal_hearing_physiology0.79646652
121MP0000383_abnormal_hair_follicle0.79054116
122MP0002078_abnormal_glucose_homeostasis0.76413011
123MP0004782_abnormal_surfactant_physiolog0.75385606
124MP0000230_abnormal_systemic_arterial0.74610819
125MP0010368_abnormal_lymphatic_system0.73703223
126MP0009765_abnormal_xenobiotic_induced0.73401390
127MP0001661_extended_life_span0.72783901
128MP0005220_abnormal_exocrine_pancreas0.72537053
129MP0005535_abnormal_body_temperature0.70846842
130MP0002168_other_aberrant_phenotype0.70687610
131MP0004147_increased_porphyrin_level0.70573950
132MP0004381_abnormal_hair_follicle0.66014724
133MP0005395_other_phenotype0.65997442
134MP0006292_abnormal_olfactory_placode0.64295634
135MP0005334_abnormal_fat_pad0.63719826
136MP0010386_abnormal_urinary_bladder0.59705233
137MP0005376_homeostasis/metabolism_phenot0.57897665
138MP0005646_abnormal_pituitary_gland0.53336319
139MP0003953_abnormal_hormone_level0.52918375
140MP0001835_abnormal_antigen_presentation0.50705560
141MP0000678_abnormal_parathyroid_gland0.49956801
142MP0008260_abnormal_autophagy0.48020362
143MP0002132_abnormal_respiratory_system0.47215024
144MP0002135_abnormal_kidney_morphology0.46034780
145MP0006082_CNS_inflammation0.45910677
146MP0001845_abnormal_inflammatory_respons0.45130907
147MP0009785_altered_susceptibility_to0.44332220
148MP0002971_abnormal_brown_adipose0.44302941
149MP0001790_abnormal_immune_system0.43886918
150MP0005387_immune_system_phenotype0.43886918
151MP0003638_abnormal_response/metabolism_0.42084095
152MP0003718_maternal_effect0.41888660
153MP0003690_abnormal_glial_cell0.41826954
154MP0001986_abnormal_taste_sensitivity0.41604851
155MP0003646_muscle_fatigue0.39890939
156MP0003879_abnormal_hair_cell0.39352491
157MP0006035_abnormal_mitochondrial_morpho0.36628593
158MP0001944_abnormal_pancreas_morphology0.34636405
159MP0001879_abnormal_lymphatic_vessel0.34229993
160MP0001177_atelectasis0.32958144
161MP0002098_abnormal_vibrissa_morphology0.32467248
162MP0009115_abnormal_fat_cell0.31869032
163MP0005075_abnormal_melanosome_morpholog0.31751528
164MP0000579_abnormal_nail_morphology0.31488428
165MP0000371_diluted_coat_color0.31068151
166MP0003656_abnormal_erythrocyte_physiolo0.29663600
167MP0003136_yellow_coat_color0.29376755
168MP0008872_abnormal_physiological_respon0.29362885
169MP0005448_abnormal_energy_balance0.29348240
170MP0001919_abnormal_reproductive_system0.28141559
171MP0003436_decreased_susceptibility_to0.28082412

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.66200359
2Intrahepatic cholestasis (HP:0001406)5.36545172
3Prolonged partial thromboplastin time (HP:0003645)4.81673454
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.68752831
5Hyperglycinuria (HP:0003108)4.68035407
6Abnormality of glutamine family amino acid metabolism (HP:0010902)4.46332415
7Pancreatic cysts (HP:0001737)4.28210136
8Joint hemorrhage (HP:0005261)4.17043801
9Xanthomatosis (HP:0000991)4.16081382
10Deep venous thrombosis (HP:0002625)4.13954374
11Gout (HP:0001997)4.08629490
12Abnormality of serine family amino acid metabolism (HP:0010894)4.07819633
13Abnormality of glycine metabolism (HP:0010895)4.07819633
14Abnormality of aspartate family amino acid metabolism (HP:0010899)3.99816968
15Hyperglycinemia (HP:0002154)3.95543637
16Generalized aminoaciduria (HP:0002909)3.94160343
17Conjugated hyperbilirubinemia (HP:0002908)3.92093849
18Congenital stationary night blindness (HP:0007642)3.87246436
19Proximal tubulopathy (HP:0000114)3.84003336
20Pancreatic fibrosis (HP:0100732)3.81336754
21Ketosis (HP:0001946)3.79747605
22Abnormality of midbrain morphology (HP:0002418)3.77867114
23Molar tooth sign on MRI (HP:0002419)3.77867114
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.73647213
25Abnormality of fatty-acid metabolism (HP:0004359)3.64323368
26True hermaphroditism (HP:0010459)3.61568892
27Hyperammonemia (HP:0001987)3.61274826
28Alkalosis (HP:0001948)3.55935562
29Hypokalemic alkalosis (HP:0001949)3.52246796
30Abnormality of purine metabolism (HP:0004352)3.51725312
31Nephronophthisis (HP:0000090)3.51523524
32Hyperactive renin-angiotensin system (HP:0000841)3.50899826
33Metabolic alkalosis (HP:0200114)3.44478974
34Abnormality of nucleobase metabolism (HP:0010932)3.43889682
35Hypobetalipoproteinemia (HP:0003563)3.40834248
36Increased circulating renin level (HP:0000848)3.34946790
37Polyuria (HP:0000103)3.33255530
38Hyperlipoproteinemia (HP:0010980)3.32163238
39Ketoacidosis (HP:0001993)3.31164765
40Abnormality of methionine metabolism (HP:0010901)3.30566684
41Hypomagnesemia (HP:0002917)3.30110738
42Abnormality of pyrimidine metabolism (HP:0004353)3.28218422
43Abnormal urine output (HP:0012590)3.26779473
44Type II lissencephaly (HP:0007260)3.24945657
45Vascular calcification (HP:0004934)3.22907315
46Hypoglycemic coma (HP:0001325)3.19543936
47Epidermoid cyst (HP:0200040)3.16284288
48Clumsiness (HP:0002312)3.13213631
49Glycosuria (HP:0003076)3.13070271
50Abnormality of urine glucose concentration (HP:0011016)3.13070271
51Complement deficiency (HP:0004431)3.08123919
52Delayed CNS myelination (HP:0002188)3.04670220
53Abnormality of renal excretion (HP:0011036)3.04592643
54Fat malabsorption (HP:0002630)3.03556988
55Renal cortical cysts (HP:0000803)3.03035274
56Increased purine levels (HP:0004368)3.00121030
57Hyperuricemia (HP:0002149)3.00121030
58Abnormality of chloride homeostasis (HP:0011422)2.98824818
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.97957279
60Abnormality of alanine metabolism (HP:0010916)2.97957279
61Hyperalaninemia (HP:0003348)2.97957279
62Abnormality of the renal medulla (HP:0100957)2.96002742
63Attenuation of retinal blood vessels (HP:0007843)2.94469546
64Enlarged kidneys (HP:0000105)2.92948174
65Abnormality of serum amino acid levels (HP:0003112)2.91135341
66Abolished electroretinogram (ERG) (HP:0000550)2.86954845
67Metabolic acidosis (HP:0001942)2.86043538
68Decreased circulating renin level (HP:0003351)2.82980882
69Abnormal drinking behavior (HP:0030082)2.80229136
70Polydipsia (HP:0001959)2.80229136
71Cardiovascular calcification (HP:0011915)2.76725857
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.76613077
73Dicarboxylic aciduria (HP:0003215)2.76613077
74Cystic liver disease (HP:0006706)2.74459744
75Abnormality of magnesium homeostasis (HP:0004921)2.70383379
76Pendular nystagmus (HP:0012043)2.68776669
77Rickets (HP:0002748)2.68463927
78Inability to walk (HP:0002540)2.67767534
79Hyperventilation (HP:0002883)2.66383595
80Hyperbilirubinemia (HP:0002904)2.64762441
81Abnormality of the common coagulation pathway (HP:0010990)2.63112746
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.62393360
83Lethargy (HP:0001254)2.61676127
84Tubular atrophy (HP:0000092)2.61227379
85Hypophosphatemic rickets (HP:0004912)2.59784785
86Large for gestational age (HP:0001520)2.59636187
87Hypolipoproteinemia (HP:0010981)2.58813780
88Hepatocellular carcinoma (HP:0001402)2.55097833
89Congenital, generalized hypertrichosis (HP:0004540)2.50983434
90Hypoglycemic seizures (HP:0002173)2.48585595
91Tetany (HP:0001281)2.47490561
92Renal tubular acidosis (HP:0001947)2.47484114
93Decreased central vision (HP:0007663)2.46042547
94Medial flaring of the eyebrow (HP:0010747)2.42769924
95Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.41086333
96Abnormality of proline metabolism (HP:0010907)2.40626274
97Hydroxyprolinuria (HP:0003080)2.40626274
98Progressive inability to walk (HP:0002505)2.39369453
99Hypoalphalipoproteinemia (HP:0003233)2.38412078
100Abnormality of renin-angiotensin system (HP:0000847)2.38349254
101Hyperaldosteronism (HP:0000859)2.38010526
102Sclerocornea (HP:0000647)2.37679600
103Abnormal rod and cone electroretinograms (HP:0008323)2.36430538
104Cerebellar dysplasia (HP:0007033)2.35826837
105Methylmalonic aciduria (HP:0012120)2.32800380
106Mitochondrial inheritance (HP:0001427)2.32587510
107Abnormality of the intrinsic pathway (HP:0010989)2.30000284
108Symptomatic seizures (HP:0011145)2.29530260
109Increased CSF lactate (HP:0002490)2.28775706
110Vomiting (HP:0002013)2.28614734
111Abnormality of the renal cortex (HP:0011035)2.27375617
112Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23401631
113Abnormality of renal resorption (HP:0011038)2.23104554
114Steatorrhea (HP:0002570)2.21887210
115Hyperphosphaturia (HP:0003109)2.21753360
116Dynein arm defect of respiratory motile cilia (HP:0012255)2.20628497
117Absent/shortened dynein arms (HP:0200106)2.20628497
118Hypercholesterolemia (HP:0003124)2.20178852
119Increased corneal curvature (HP:0100692)2.19649953
120Keratoconus (HP:0000563)2.19649953
121Methylmalonic acidemia (HP:0002912)2.17969316
122Abnormal urine phosphate concentration (HP:0012599)2.17407732
123Gaze-evoked nystagmus (HP:0000640)2.16669915
124Acute necrotizing encephalopathy (HP:0006965)2.15708956
125Hypophosphatemia (HP:0002148)2.15708599
126Cerebral edema (HP:0002181)2.15616806
127Disproportionate short-trunk short stature (HP:0003521)2.15350125
128Abnormality of complement system (HP:0005339)2.13913035
129Abnormal enzyme/coenzyme activity (HP:0012379)2.13291056
130Myocardial infarction (HP:0001658)2.13244908
131Chronic hepatic failure (HP:0100626)2.13148983
132Bile duct proliferation (HP:0001408)2.12535152
133Abnormal biliary tract physiology (HP:0012439)2.12535152
134Aplasia/Hypoplasia of the tibia (HP:0005772)2.11940559
135Abnormality of the pons (HP:0007361)2.10918854
136Renal tubular dysfunction (HP:0000124)2.10547719
137Concave nail (HP:0001598)2.07939637
138Furrowed tongue (HP:0000221)2.07615898
139Confusion (HP:0001289)2.07551829
140Hypothermia (HP:0002045)2.06787923
141Congenital sensorineural hearing impairment (HP:0008527)2.05762952
142Hepatocellular necrosis (HP:0001404)2.04990810
143Severe muscular hypotonia (HP:0006829)2.04187005
144Opisthotonus (HP:0002179)2.03383369
145Genetic anticipation (HP:0003743)2.03369582
146Nephrolithiasis (HP:0000787)2.03339333
147Chorioretinal atrophy (HP:0000533)2.02094555
148Mitral stenosis (HP:0001718)2.01988274
149Congenital hepatic fibrosis (HP:0002612)2.01519499
150Pancreatitis (HP:0001733)2.00617844
151Hypoplasia of the pons (HP:0012110)2.00615175
152Hepatic necrosis (HP:0002605)2.00614376
153Irritability (HP:0000737)2.00421600
154Anencephaly (HP:0002323)2.00410782
155Malnutrition (HP:0004395)1.98286172
156Lipid accumulation in hepatocytes (HP:0006561)1.98212313
157Aplasia/Hypoplasia of the patella (HP:0006498)1.97844661
158Progressive cerebellar ataxia (HP:0002073)1.97783790
159Abnormality of alkaline phosphatase activity (HP:0004379)1.97258061
160Renal salt wasting (HP:0000127)1.96216901
161Optic disc pallor (HP:0000543)1.94327496
162Aplasia/Hypoplasia of the tongue (HP:0010295)1.93635897
163Broad-based gait (HP:0002136)1.93137879
164Bony spicule pigmentary retinopathy (HP:0007737)1.92769395
165Acute encephalopathy (HP:0006846)1.90363588
166Abnormal respiratory epithelium morphology (HP:0012253)1.89684538
167Abnormal respiratory motile cilium morphology (HP:0005938)1.89684538
168Lissencephaly (HP:0001339)1.88868616
169Patellar aplasia (HP:0006443)1.87667850
170Male pseudohermaphroditism (HP:0000037)1.87112799
171Progressive macrocephaly (HP:0004481)1.85475973
172Febrile seizures (HP:0002373)1.85269143
173Abnormal mitochondria in muscle tissue (HP:0008316)1.84533349
174Gait imbalance (HP:0002141)1.84516093
175Tachypnea (HP:0002789)1.82258601
176Abnormal albumin level (HP:0012116)1.80828080
177Hypoalbuminemia (HP:0003073)1.80828080
178Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78570771
179Abnormality of macular pigmentation (HP:0008002)1.78517306
180Increased hepatocellular lipid droplets (HP:0006565)1.77549604
181Hemiparesis (HP:0001269)1.77143807
182Abnormal ciliary motility (HP:0012262)1.76508687
183Limb dystonia (HP:0002451)1.76398084
184Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76000934
185Stomach cancer (HP:0012126)1.74861741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.39883826
2INSRR4.15965817
3WNK43.87992648
4WNK33.78684864
5BCKDK3.71521034
6IRAK33.34988754
7OXSR13.25673816
8ZAK3.21813848
9MAP4K22.58186293
10STK38L2.49022679
11ACVR1B2.47261123
12FGFR42.44125932
13MAP3K142.28548960
14CASK2.15005347
15PINK12.06296463
16MAPK152.01100816
17TAOK31.91504499
18MAPK131.86564035
19IRAK21.84592631
20IRAK41.76790103
21TIE11.73179537
22DAPK21.72134999
23SGK21.72032012
24GRK11.69596113
25SIK11.64186219
26SGK2231.56489049
27SGK4941.56489049
28PHKG21.51112172
29PHKG11.51112172
30MAP3K41.45366311
31PIK3CG1.44535359
32AKT31.41404423
33PNCK1.40376994
34IRAK11.33303809
35MAP2K71.31871148
36TXK1.30730985
37ERBB41.26254028
38ADRBK11.21826487
39MARK11.16153124
40STK391.15737232
41CAMKK21.12420758
42MAPK111.11924722
43ERN11.10734214
44DYRK21.10404923
45SGK31.08204310
46TGFBR11.05629170
47PAK31.05365569
48MAPKAPK31.02709564
49BMPR21.02689546
50TYK21.00286626
51NTRK30.94343106
52BMPR1B0.93764812
53CDK30.91968435
54SIK30.91917684
55PRKAA20.89527763
56PLK40.87921236
57TEC0.82811866
58ADRBK20.81678641
59PKN10.81636916
60MAPKAPK50.81586635
61IKBKE0.80992792
62YES10.79159253
63MST1R0.73650749
64JAK10.71744650
65KDR0.71475702
66TAOK20.71349987
67NEK90.71164471
68PLK20.70933187
69PDK20.70214270
70FRK0.69537235
71MAPK70.68856791
72NME10.68416531
73EIF2AK20.67709466
74MKNK20.67188712
75EPHA40.65212473
76PRKAA10.64988478
77IKBKB0.64839506
78BTK0.64473071
79VRK10.64056295
80TGFBR20.63011959
81MAPK40.62954895
82NEK60.61878623
83CSNK1G20.61810461
84MAP3K70.61445866
85NUAK10.61231455
86CSNK1G10.60483652
87PTK2B0.60056892
88CHUK0.59994483
89GRK70.59647352
90PRKCI0.59440949
91CAMK10.59298093
92EPHA30.58494907
93CAMK1D0.58192559
94ABL20.58138131
95NEK20.57881644
96FGFR20.56948251
97PBK0.55824512
98CAMK2A0.55604953
99BRSK20.54235724
100NLK0.53474257
101TRIM280.53318405
102CSNK1G30.50290159
103FLT30.49130323
104NTRK20.48894269
105MAP2K40.48216842
106MYLK0.47731670
107STK40.46514162
108JAK20.46333228
109RPS6KA50.45668585
110GRK60.45443369
111* PRKACA0.44894035
112JAK30.44796690
113STK110.44755073
114STK160.44414326
115CAMK40.43137584
116WEE10.42396969
117MAP2K60.42330482
118TNK20.41504163
119DYRK1B0.41181003
120PRKCE0.40444257
121PRKD20.39579907
122CSNK1A10.39370824
123SGK10.39242389
124PRKCQ0.38224619
125CSNK1A1L0.38165447
126PRKACG0.38112737
127PRKG10.38043022
128OBSCN0.37276872
129PIM10.37195551
130MST40.37113763
131PRKCA0.36857330
132CAMK2G0.36509536
133GSK3A0.36423267
134PRKCZ0.36334847
135GRK50.35504155
136PIK3CA0.34412210
137CDK90.34401780
138CAMK1G0.33853922
139CSK0.33701415
140LYN0.33535762
141PRKCG0.33192393
142MAPK120.32993861
143PRKCD0.32737410
144LATS10.32593995
145KIT0.32559237
146TNIK0.32348358
147WNK10.32204305
148ITK0.30299777
149SIK20.30187772
150MUSK0.29878459
151MAP2K20.29592757
152CSNK1D0.29347482
153PLK30.28936973
154CAMKK10.27783026
155MKNK10.26909238
156MAP2K10.26397621
157CDK190.25651510
158EIF2AK30.25135016

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.84213229
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.48958317
3Tryptophan metabolism_Homo sapiens_hsa003802.88279657
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.83046153
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.72730783
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.68703593
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58770014
8Butanoate metabolism_Homo sapiens_hsa006502.57732133
9Phototransduction_Homo sapiens_hsa047442.56476451
10Peroxisome_Homo sapiens_hsa041462.56171711
11Fatty acid degradation_Homo sapiens_hsa000712.51299738
12Arginine biosynthesis_Homo sapiens_hsa002202.41196962
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37281669
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34650628
15Propanoate metabolism_Homo sapiens_hsa006402.23759094
16Complement and coagulation cascades_Homo sapiens_hsa046102.17143380
17beta-Alanine metabolism_Homo sapiens_hsa004102.15424597
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15145577
19Steroid hormone biosynthesis_Homo sapiens_hsa001402.06273452
20Histidine metabolism_Homo sapiens_hsa003402.04526038
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91642365
22Nicotine addiction_Homo sapiens_hsa050331.90655049
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.85672288
24Parkinsons disease_Homo sapiens_hsa050121.85658009
25Nitrogen metabolism_Homo sapiens_hsa009101.85131722
26Chemical carcinogenesis_Homo sapiens_hsa052041.81095930
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80694271
28Retinol metabolism_Homo sapiens_hsa008301.77595497
29Fatty acid metabolism_Homo sapiens_hsa012121.74240491
30Ether lipid metabolism_Homo sapiens_hsa005651.70503163
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69172950
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.68059519
33PPAR signaling pathway_Homo sapiens_hsa033201.66625051
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.62766704
35RNA polymerase_Homo sapiens_hsa030201.61170536
36Vitamin digestion and absorption_Homo sapiens_hsa049771.57272696
37Phenylalanine metabolism_Homo sapiens_hsa003601.56832952
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.56105002
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55415501
40Selenocompound metabolism_Homo sapiens_hsa004501.54002090
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.52415794
42Homologous recombination_Homo sapiens_hsa034401.51911812
43Starch and sucrose metabolism_Homo sapiens_hsa005001.51782096
44Cardiac muscle contraction_Homo sapiens_hsa042601.48991127
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46389419
46Sulfur metabolism_Homo sapiens_hsa009201.45918078
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42467461
48Pyruvate metabolism_Homo sapiens_hsa006201.41512243
49Staphylococcus aureus infection_Homo sapiens_hsa051501.40551254
50Folate biosynthesis_Homo sapiens_hsa007901.35989136
51Protein export_Homo sapiens_hsa030601.35638016
52Taste transduction_Homo sapiens_hsa047421.35190978
53Bile secretion_Homo sapiens_hsa049761.34395395
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34089649
55ABC transporters_Homo sapiens_hsa020101.33791778
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32799780
57Fatty acid elongation_Homo sapiens_hsa000621.31085070
58Arginine and proline metabolism_Homo sapiens_hsa003301.29758467
59Tyrosine metabolism_Homo sapiens_hsa003501.29004292
60Huntingtons disease_Homo sapiens_hsa050161.23779225
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20045003
62Alzheimers disease_Homo sapiens_hsa050101.14155434
63Basal transcription factors_Homo sapiens_hsa030221.13925613
64Insulin secretion_Homo sapiens_hsa049111.13243806
65Lysine degradation_Homo sapiens_hsa003101.12986676
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11809158
67Steroid biosynthesis_Homo sapiens_hsa001001.11118646
68* Morphine addiction_Homo sapiens_hsa050321.08965762
69Olfactory transduction_Homo sapiens_hsa047401.08061610
70Fanconi anemia pathway_Homo sapiens_hsa034601.07061661
71Caffeine metabolism_Homo sapiens_hsa002321.06786703
72GABAergic synapse_Homo sapiens_hsa047271.02014148
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.94228216
74Circadian entrainment_Homo sapiens_hsa047130.94114281
75Vitamin B6 metabolism_Homo sapiens_hsa007500.92128186
76Carbon metabolism_Homo sapiens_hsa012000.91257352
77RNA degradation_Homo sapiens_hsa030180.88878242
78Serotonergic synapse_Homo sapiens_hsa047260.88723031
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87498542
80Glutathione metabolism_Homo sapiens_hsa004800.87243776
81Glutamatergic synapse_Homo sapiens_hsa047240.86094000
82One carbon pool by folate_Homo sapiens_hsa006700.79243936
83Calcium signaling pathway_Homo sapiens_hsa040200.71969594
84Biosynthesis of amino acids_Homo sapiens_hsa012300.69941534
85Asthma_Homo sapiens_hsa053100.66450052
86Metabolic pathways_Homo sapiens_hsa011000.64237807
87Sulfur relay system_Homo sapiens_hsa041220.64136977
88Glycerolipid metabolism_Homo sapiens_hsa005610.63132971
89* Purine metabolism_Homo sapiens_hsa002300.62135305
90Salivary secretion_Homo sapiens_hsa049700.60864576
91Fat digestion and absorption_Homo sapiens_hsa049750.58026269
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55554022
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.49045078
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47101203
95Type I diabetes mellitus_Homo sapiens_hsa049400.46329672
96Dopaminergic synapse_Homo sapiens_hsa047280.45829963
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44828690
98Cocaine addiction_Homo sapiens_hsa050300.43536609
99Amphetamine addiction_Homo sapiens_hsa050310.43162374
100Circadian rhythm_Homo sapiens_hsa047100.41899698
101Arachidonic acid metabolism_Homo sapiens_hsa005900.41416494
102Pentose phosphate pathway_Homo sapiens_hsa000300.41246267
103Cholinergic synapse_Homo sapiens_hsa047250.40644239
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39210912
105Ribosome_Homo sapiens_hsa030100.38356627
106Other glycan degradation_Homo sapiens_hsa005110.38045560
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35080199
108Oxytocin signaling pathway_Homo sapiens_hsa049210.30076516
109Linoleic acid metabolism_Homo sapiens_hsa005910.26804074
110Galactose metabolism_Homo sapiens_hsa000520.24931501
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.21841108
112Fructose and mannose metabolism_Homo sapiens_hsa000510.20096769
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15332890
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.15279777
115Regulation of autophagy_Homo sapiens_hsa041400.13507691
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11685289
117Mineral absorption_Homo sapiens_hsa049780.11558615
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10132717
119Sphingolipid metabolism_Homo sapiens_hsa006000.09369283
120Insulin resistance_Homo sapiens_hsa049310.08182147
121Collecting duct acid secretion_Homo sapiens_hsa049660.08044871
122Protein digestion and absorption_Homo sapiens_hsa049740.05226118
123Fatty acid biosynthesis_Homo sapiens_hsa000610.04197122
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.03332441
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.02995654
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.02420573
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.02262426
128Ovarian steroidogenesis_Homo sapiens_hsa049130.00021790
129Prion diseases_Homo sapiens_hsa05020-0.0859907
130Glucagon signaling pathway_Homo sapiens_hsa04922-0.0841116
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0799400
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0666587
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0463479
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0398413
135Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0353537
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0314759
137Primary immunodeficiency_Homo sapiens_hsa05340-0.0182618
138Oxidative phosphorylation_Homo sapiens_hsa00190-0.0030346

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