PDE4D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cAMP catabolic process (GO:0006198)5.70350973
2* cyclic nucleotide catabolic process (GO:0009214)5.10362739
3protein prenylation (GO:0018342)4.83884114
4prenylation (GO:0097354)4.83884114
5monoubiquitinated protein deubiquitination (GO:0035520)4.58178828
6postsynaptic membrane organization (GO:0001941)4.48629054
7neuron cell-cell adhesion (GO:0007158)4.42447545
8interkinetic nuclear migration (GO:0022027)4.42443934
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.37413240
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.31539587
11negative regulation of complement activation (GO:0045916)4.26746872
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.22199275
13neurotransmitter-gated ion channel clustering (GO:0072578)4.21741871
14vocalization behavior (GO:0071625)4.17506404
15presynaptic membrane assembly (GO:0097105)4.14922469
16positive regulation of vascular permeability (GO:0043117)4.08291387
17response to dexamethasone (GO:0071548)4.01104121
18neuronal action potential propagation (GO:0019227)3.98832186
19pericardium development (GO:0060039)3.89741550
20peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.86990050
21midgut development (GO:0007494)3.82542011
22citrulline biosynthetic process (GO:0019240)3.81787090
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.81674977
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.80083800
25positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.79087279
26synaptic vesicle exocytosis (GO:0016079)3.74416758
27nucleus localization (GO:0051647)3.72904549
28negative regulation of protein activation cascade (GO:2000258)3.70975442
29regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.69088647
30Rap protein signal transduction (GO:0032486)3.67349923
31regulation of glutamate receptor signaling pathway (GO:1900449)3.58934849
32* regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.57059021
33regulation of synaptic vesicle transport (GO:1902803)3.56885481
34regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.54094990
35regulation of energy homeostasis (GO:2000505)3.52318357
36skeletal muscle contraction (GO:0003009)3.51230023
37positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.47998317
38glutamate secretion (GO:0014047)3.47419859
39muscle filament sliding (GO:0030049)3.46278485
40actin-myosin filament sliding (GO:0033275)3.46278485
41nuclear pore complex assembly (GO:0051292)3.45246623
42hepatocyte differentiation (GO:0070365)3.44789132
43negative regulation of vascular permeability (GO:0043116)3.44473776
44glycogen catabolic process (GO:0005980)3.42951549
45* regulation of cell communication by electrical coupling (GO:0010649)3.42642044
46presynaptic membrane organization (GO:0097090)3.41364627
47regulation of skeletal muscle contraction (GO:0014819)3.41209789
48phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.40332286
49regulation of synaptic vesicle exocytosis (GO:2000300)3.39827203
50response to growth hormone (GO:0060416)3.38104707
51protein localization to synapse (GO:0035418)3.37931677
52sarcoplasmic reticulum calcium ion transport (GO:0070296)3.36563468
53pathway-restricted SMAD protein phosphorylation (GO:0060389)3.32852277
54regulation of short-term neuronal synaptic plasticity (GO:0048172)3.32528955
55synaptic vesicle endocytosis (GO:0048488)3.29516020
56protein K11-linked deubiquitination (GO:0035871)3.20542582
57regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.19473132
58glucan catabolic process (GO:0009251)3.19431305
59cGMP-mediated signaling (GO:0019934)3.17905474
60actin filament-based movement (GO:0030048)3.17173299
61inositol phosphate catabolic process (GO:0071545)3.15585127
62regulation of centriole replication (GO:0046599)3.15228612
63regulation of acyl-CoA biosynthetic process (GO:0050812)3.15120871
64positive regulation of odontogenesis (GO:0042482)3.13803564
65mechanosensory behavior (GO:0007638)3.12929788
66negative regulation of humoral immune response (GO:0002921)3.10507097
67membrane depolarization during action potential (GO:0086010)3.07814654
68homocysteine metabolic process (GO:0050667)3.07384064
69synaptic transmission, glutamatergic (GO:0035249)3.06856055
70fibroblast migration (GO:0010761)3.03850613
71negative regulation of dendrite development (GO:2000171)3.02301880
72negative regulation of B cell mediated immunity (GO:0002713)3.00867975
73negative regulation of immunoglobulin mediated immune response (GO:0002890)3.00867975
74cellular polysaccharide catabolic process (GO:0044247)2.98973151
75positive regulation of phosphatase activity (GO:0010922)2.98611953
76actomyosin structure organization (GO:0031032)2.95518929
77protein K48-linked deubiquitination (GO:0071108)2.95198118
78regulation of skeletal muscle cell differentiation (GO:2001014)2.93930837
79regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.93838749
80cerebellar Purkinje cell differentiation (GO:0021702)2.92036274
81neuron-neuron synaptic transmission (GO:0007270)2.91914083
82* regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.91580020
83startle response (GO:0001964)2.90852007
84regulation of steroid hormone biosynthetic process (GO:0090030)2.89696741
85neuromuscular synaptic transmission (GO:0007274)2.87552598
86regulation of synapse structural plasticity (GO:0051823)2.87204949
87striated muscle contraction (GO:0006941)2.87076442
88carnitine shuttle (GO:0006853)2.85951777
89locomotory exploration behavior (GO:0035641)2.85222155
90* regulation of relaxation of muscle (GO:1901077)2.84924670
91regulation of coenzyme metabolic process (GO:0051196)2.82485500
92regulation of cofactor metabolic process (GO:0051193)2.82485500
93actin-mediated cell contraction (GO:0070252)2.82242981
94axonal fasciculation (GO:0007413)2.81705081
95NADH metabolic process (GO:0006734)2.80373360
96cardiac myofibril assembly (GO:0055003)2.79453962
97cardiac muscle hypertrophy (GO:0003300)2.79322810
98proline transport (GO:0015824)2.75043646
99* regulation of actin filament-based movement (GO:1903115)2.74952520
100regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.74553214
101iron ion import (GO:0097286)2.74364166
102nuclear pore organization (GO:0006999)2.74201719
103neutrophil mediated immunity (GO:0002446)2.73841013
104striated muscle hypertrophy (GO:0014897)2.73563747
105oxygen transport (GO:0015671)2.72915945
106cytoplasmic mRNA processing body assembly (GO:0033962)2.72276467
107myeloid leukocyte mediated immunity (GO:0002444)2.72068191
108neurotransmitter secretion (GO:0007269)2.71646617
109protein K63-linked deubiquitination (GO:0070536)2.71526821
110long-term synaptic potentiation (GO:0060291)2.70659628
111genitalia morphogenesis (GO:0035112)2.68460754
112response to inactivity (GO:0014854)2.66404938
113regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.66306286
114striated muscle atrophy (GO:0014891)2.65900231
115positive regulation of neurotransmitter secretion (GO:0001956)2.65260694
116carnitine transmembrane transport (GO:1902603)2.64687082
117myotube cell development (GO:0014904)2.64535376
118ionotropic glutamate receptor signaling pathway (GO:0035235)2.64234617
119morphogenesis of an epithelial sheet (GO:0002011)2.63158245
120negative regulation of TOR signaling (GO:0032007)2.62405584
121response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.62244393
122regulation of p38MAPK cascade (GO:1900744)2.62145989
123skeletal muscle adaptation (GO:0043501)2.61408451
124polysaccharide catabolic process (GO:0000272)2.61368420
125regulation of respiratory system process (GO:0044065)2.61259435
126G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.58992304
127positive regulation of cation channel activity (GO:2001259)2.58514332
128cellular response to ethanol (GO:0071361)2.58474052
129negative regulation of hormone metabolic process (GO:0032351)2.58294405
130interferon-gamma production (GO:0032609)2.58247004
131citrulline metabolic process (GO:0000052)2.58148798
132cerebellar granule cell differentiation (GO:0021707)2.56384269
133negative regulation of dendrite morphogenesis (GO:0050774)2.55866354
134regulation of excitatory postsynaptic membrane potential (GO:0060079)2.55367487
135neuron recognition (GO:0008038)2.54872149
136negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.54662285
137dorsal/ventral axis specification (GO:0009950)2.54473173
138establishment of protein localization to Golgi (GO:0072600)2.54104319
139negative regulation of neurotransmitter secretion (GO:0046929)2.53214049
140positive regulation of cardiac muscle cell differentiation (GO:2000727)2.52439453
141positive regulation of synapse assembly (GO:0051965)2.51887814
142positive regulation of myoblast differentiation (GO:0045663)2.51318534
143positive regulation of astrocyte differentiation (GO:0048711)2.50885961
144positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.50060405
145striated muscle adaptation (GO:0014888)2.49954896
146pore complex assembly (GO:0046931)2.48566041
147tricarboxylic acid cycle (GO:0006099)2.48488443
148myofibril assembly (GO:0030239)2.48437946
149retrograde transport, vesicle recycling within Golgi (GO:0000301)2.48228915
150* cAMP metabolic process (GO:0046058)2.48091779
151* regulation of calcium ion transmembrane transporter activity (GO:1901019)2.48075077
152* regulation of calcium ion transmembrane transport (GO:1903169)2.48075077
153regulation of NFAT protein import into nucleus (GO:0051532)2.47924471
154regulation of synaptic transmission, glutamatergic (GO:0051966)2.47776293
155muscle cell cellular homeostasis (GO:0046716)2.47710714
156fatty acid transmembrane transport (GO:1902001)2.47196250
157membrane depolarization (GO:0051899)2.46024140
158inositol phosphate dephosphorylation (GO:0046855)2.45949396
159phosphorylated carbohydrate dephosphorylation (GO:0046838)2.45949396
160regulation of neurotransmitter secretion (GO:0046928)2.45612353
161urea cycle (GO:0000050)2.45277460
162* regulation of striated muscle contraction (GO:0006942)2.44968866
163sarcomere organization (GO:0045214)2.44542657
164regulation of synapse assembly (GO:0051963)2.44250506
165glutamate receptor signaling pathway (GO:0007215)2.41318852
166innervation (GO:0060384)2.40556239
167regulation of postsynaptic membrane potential (GO:0060078)2.39110303
168positive regulation of gamma-delta T cell activation (GO:0046645)2.39031777
169positive regulation of neurotransmitter transport (GO:0051590)2.38973937
170opioid receptor signaling pathway (GO:0038003)2.38509472
171detection of calcium ion (GO:0005513)2.38316513
172negative regulation of synaptic transmission, GABAergic (GO:0032229)2.36980741
173positive T cell selection (GO:0043368)2.36329066
174response to interleukin-15 (GO:0070672)2.36250464
175regulation of sarcomere organization (GO:0060297)2.35199883
176positive regulation of membrane potential (GO:0045838)2.34978058
177cardiac muscle contraction (GO:0060048)2.34860438
178behavioral response to pain (GO:0048266)2.33472435
179tolerance induction (GO:0002507)2.33468319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.95428297
2GBX2_23144817_ChIP-Seq_PC3_Human4.49100236
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.85775418
4* BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.36500548
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.01132725
6AR_21572438_ChIP-Seq_LNCaP_Human2.88875125
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.71276017
8TAF15_26573619_Chip-Seq_HEK293_Human2.62406399
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43635030
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42889998
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39152709
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35354547
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.27014138
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24933670
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22837806
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19279961
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.18319690
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16359439
19IGF1R_20145208_ChIP-Seq_DFB_Human2.12892976
20* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.11412630
21* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10439845
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10235572
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.02760291
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02660025
25* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93667228
26DROSHA_22980978_ChIP-Seq_HELA_Human1.93046035
27P300_19829295_ChIP-Seq_ESCs_Human1.92394284
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89746116
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88275421
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84870304
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84765170
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.82381216
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80873936
34REST_21632747_ChIP-Seq_MESCs_Mouse1.74228771
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73127180
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73127180
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68036390
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68030267
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68015660
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67981260
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.67180583
42ER_23166858_ChIP-Seq_MCF-7_Human1.64935666
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63788811
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.59977637
45FUS_26573619_Chip-Seq_HEK293_Human1.59105420
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.58356589
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.58356589
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.57935104
49SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55674524
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54431056
51FOXM1_26456572_ChIP-Seq_MCF-7_Human1.53484720
52AR_25329375_ChIP-Seq_VCAP_Human1.52678337
53* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51530900
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51269706
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.50689481
56* REST_18959480_ChIP-ChIP_MESCs_Mouse1.50272026
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.47262986
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45828699
59* SOX2_21211035_ChIP-Seq_LN229_Gbm1.45319960
60RARB_27405468_Chip-Seq_BRAIN_Mouse1.45286009
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43787703
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42422363
63* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.41283072
64* STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41209627
65* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41080269
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40527263
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.40347783
68RUNX_20019798_ChIP-Seq_JUKART_Human1.39286753
69* TCF4_23295773_ChIP-Seq_U87_Human1.38440345
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37658022
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.37294905
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.36166218
73* STAT3_23295773_ChIP-Seq_U87_Human1.35887680
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34222989
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.33434184
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32113512
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31612218
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31069240
79EWS_26573619_Chip-Seq_HEK293_Human1.30558999
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30339091
81CJUN_26792858_Chip-Seq_BT549_Human1.29951489
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29237393
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28340139
84GATA1_22025678_ChIP-Seq_K562_Human1.27312364
85* EP300_21415370_ChIP-Seq_HL-1_Mouse1.26328585
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.25989812
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.23484174
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.22650566
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.20469445
90TP53_16413492_ChIP-PET_HCT116_Human1.19498032
91PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19112957
92* SOX9_26525672_Chip-Seq_HEART_Mouse1.18617935
93* AR_19668381_ChIP-Seq_PC3_Human1.16905987
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.15671926
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.14106298
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.12498528
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12203426
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11633459
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.11493061
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10918146
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10406318
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.10360952
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09737403
104CBP_20019798_ChIP-Seq_JUKART_Human1.09159369
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09159369
106E2F1_18555785_Chip-Seq_ESCs_Mouse1.07953016
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07881595
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07458721
109* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07394639
110* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06111712
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04714638
112* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04636267
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03588675
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03022565
115FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02942100
116PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02888093
117RUNX2_22187159_ChIP-Seq_PCA_Human1.02868706
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02502712
119SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02041823
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.01240209
121RNF2_27304074_Chip-Seq_NSC_Mouse1.01131794
122Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01036761
123BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00772742
124CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00674948
125P53_22387025_ChIP-Seq_ESCs_Mouse0.99890124
126* SMAD3_21741376_ChIP-Seq_HESCs_Human0.99164372
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98873367
128* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98607855
129TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98604843
130BRD4_25478319_ChIP-Seq_HGPS_Human0.98549387
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.98084263
132PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98030242
133TP53_18474530_ChIP-ChIP_U2OS_Human0.97821592
134MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97587087
135BCAT_22108803_ChIP-Seq_LS180_Human0.97558897
136AHR_22903824_ChIP-Seq_MCF-7_Human0.95777609
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93850056
138KDM2B_26808549_Chip-Seq_REH_Human0.93357292
139EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92837907
140* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92827267
141SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92591311
142FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92070116
143STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89867751
144* JUN_21703547_ChIP-Seq_K562_Human0.88137658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract4.72190998
2MP0002009_preneoplasia4.11232820
3MP0008057_abnormal_DNA_replication3.57303327
4MP0004145_abnormal_muscle_electrophysio3.44858045
5MP0004859_abnormal_synaptic_plasticity3.24693760
6MP0003880_abnormal_central_pattern3.18327205
7MP0003646_muscle_fatigue3.10950578
8MP0000751_myopathy3.09980966
9MP0000749_muscle_degeneration3.07210970
10MP0002837_dystrophic_cardiac_calcinosis2.87384001
11MP0003787_abnormal_imprinting2.66908070
12MP0001188_hyperpigmentation2.56870445
13MP0003635_abnormal_synaptic_transmissio2.51743371
14MP0000003_abnormal_adipose_tissue2.25268602
15MP0004270_analgesia2.22071920
16MP0003950_abnormal_plasma_membrane2.08666245
17MP0009046_muscle_twitch2.06621483
18MP0003122_maternal_imprinting2.05080339
19MP0009745_abnormal_behavioral_response2.03794602
20MP0000733_abnormal_muscle_development2.02830046
21MP0006138_congestive_heart_failure2.01658857
22MP0002332_abnormal_exercise_endurance1.99145800
23MP0001968_abnormal_touch/_nociception1.99061927
24MP0001661_extended_life_span1.98897963
25MP0002063_abnormal_learning/memory/cond1.97386614
26MP0005645_abnormal_hypothalamus_physiol1.90927449
27MP0004215_abnormal_myocardial_fiber1.87999709
28MP0002736_abnormal_nociception_after1.86124311
29MP0002106_abnormal_muscle_physiology1.85568833
30MP0002166_altered_tumor_susceptibility1.85447993
31MP0002064_seizures1.76353825
32MP0004147_increased_porphyrin_level1.75369987
33MP0004036_abnormal_muscle_relaxation1.67243001
34MP0002572_abnormal_emotion/affect_behav1.62925028
35MP0002735_abnormal_chemical_nociception1.62242061
36MP0005369_muscle_phenotype1.61374575
37MP0004084_abnormal_cardiac_muscle1.60915545
38MP0002734_abnormal_mechanical_nocicepti1.58208291
39MP0002067_abnormal_sensory_capabilities1.57333976
40MP0002396_abnormal_hematopoietic_system1.57162628
41MP0005620_abnormal_muscle_contractility1.56859013
42MP0000569_abnormal_digit_pigmentation1.56761046
43MP0001529_abnormal_vocalization1.55275626
44MP0000759_abnormal_skeletal_muscle1.55008855
45MP0002184_abnormal_innervation1.54530951
46MP0008569_lethality_at_weaning1.54463243
47MP0005646_abnormal_pituitary_gland1.52015159
48MP0003121_genomic_imprinting1.51759469
49MP0010352_gastrointestinal_tract_polyps1.50966695
50MP0005423_abnormal_somatic_nervous1.50947305
51MP0003763_abnormal_thymus_physiology1.49751205
52MP0002272_abnormal_nervous_system1.41530981
53MP0001486_abnormal_startle_reflex1.39969685
54MP0000383_abnormal_hair_follicle1.37692642
55MP0004087_abnormal_muscle_fiber1.37537189
56MP0004924_abnormal_behavior1.35423228
57MP0005386_behavior/neurological_phenoty1.35423228
58MP0004130_abnormal_muscle_cell1.34922488
59MP0010630_abnormal_cardiac_muscle1.30091318
60MP0004484_altered_response_of1.27868704
61MP0001984_abnormal_olfaction1.25998240
62MP0002269_muscular_atrophy1.25927225
63MP0005248_abnormal_Harderian_gland1.21548912
64MP0000778_abnormal_nervous_system1.19678321
65MP0002557_abnormal_social/conspecific_i1.18651826
66MP0004510_myositis1.18370927
67MP0004233_abnormal_muscle_weight1.17976755
68MP0005076_abnormal_cell_differentiation1.16932956
69MP0003137_abnormal_impulse_conducting1.15863693
70MP0001501_abnormal_sleep_pattern1.15706035
71MP0002108_abnormal_muscle_morphology1.14711477
72MP0010678_abnormal_skin_adnexa1.14382898
73MP0005375_adipose_tissue_phenotype1.14181851
74MP0001502_abnormal_circadian_rhythm1.12905799
75MP0000747_muscle_weakness1.12407810
76MP0006276_abnormal_autonomic_nervous1.11374830
77MP0000015_abnormal_ear_pigmentation1.10246162
78MP0002822_catalepsy1.09796738
79MP0005171_absent_coat_pigmentation1.09394375
80MP0004811_abnormal_neuron_physiology1.08261340
81MP0000372_irregular_coat_pigmentation1.08134298
82MP0005220_abnormal_exocrine_pancreas1.06237565
83MP0004142_abnormal_muscle_tone1.05627444
84MP0002006_tumorigenesis1.05258360
85MP0002127_abnormal_cardiovascular_syste1.04142010
86MP0005085_abnormal_gallbladder_physiolo1.03321276
87MP0005266_abnormal_metabolism1.01915494
88MP0003091_abnormal_cell_migration0.98491590
89MP0004808_abnormal_hematopoietic_stem0.97256472
90MP0008775_abnormal_heart_ventricle0.96008884
91MP0001970_abnormal_pain_threshold0.94609942
92MP0004085_abnormal_heartbeat0.94567489
93* MP0002972_abnormal_cardiac_muscle0.94158272
94MP0005330_cardiomyopathy0.93570318
95MP0004742_abnormal_vestibular_system0.91294921
96MP0000013_abnormal_adipose_tissue0.90689471
97MP0001879_abnormal_lymphatic_vessel0.88957366
98MP0000955_abnormal_spinal_cord0.88691482
99MP0008961_abnormal_basal_metabolism0.87186006
100MP0005174_abnormal_tail_pigmentation0.86988840
101MP0002877_abnormal_melanocyte_morpholog0.86314441
102MP0002971_abnormal_brown_adipose0.85827448
103MP0005671_abnormal_response_to0.85054391
104MP0003172_abnormal_lysosome_physiology0.83708392
105MP0009703_decreased_birth_body0.83694739
106MP0003045_fibrosis0.83561601
107MP0002066_abnormal_motor_capabilities/c0.83534172
108MP0009780_abnormal_chondrocyte_physiolo0.80281356
109MP0001873_stomach_inflammation0.80248840
110MP0002733_abnormal_thermal_nociception0.79208401
111MP0002638_abnormal_pupillary_reflex0.78497783
112MP0002095_abnormal_skin_pigmentation0.77855284
113MP0003828_pulmonary_edema0.73038191
114MP0003183_abnormal_peptide_metabolism0.72614799
115MP0000750_abnormal_muscle_regeneration0.72510481
116MP0005253_abnormal_eye_physiology0.72250329
117MP0004134_abnormal_chest_morphology0.72216012
118MP0000230_abnormal_systemic_arterial0.71916093
119MP0002089_abnormal_postnatal_growth/wei0.71418541
120MP0002163_abnormal_gland_morphology0.67386205
121MP0000703_abnormal_thymus_morphology0.66986485
122MP0002882_abnormal_neuron_morphology0.66944574
123MP0003724_increased_susceptibility_to0.66083295
124MP0000266_abnormal_heart_morphology0.65787817
125MP0003879_abnormal_hair_cell0.65573308
126MP0001544_abnormal_cardiovascular_syste0.65568760
127MP0005385_cardiovascular_system_phenoty0.65568760
128MP0001348_abnormal_lacrimal_gland0.65345466
129MP0000427_abnormal_hair_cycle0.65313310
130MP0003959_abnormal_lean_body0.64821980
131MP0002168_other_aberrant_phenotype0.64781310
132MP0005075_abnormal_melanosome_morpholog0.63828047
133MP0003221_abnormal_cardiomyocyte_apopto0.62322466
134MP0001943_abnormal_respiration0.61733899
135MP0005409_darkened_coat_color0.60779741
136MP0000465_gastrointestinal_hemorrhage0.60348181
137MP0001851_eye_inflammation0.59434878
138MP0003633_abnormal_nervous_system0.58867357
139MP0002088_abnormal_embryonic_growth/wei0.56658563
140MP0009115_abnormal_fat_cell0.56656446
141MP0001784_abnormal_fluid_regulation0.56324787
142MP0002128_abnormal_blood_circulation0.56207342
143MP0010234_abnormal_vibrissa_follicle0.55981829
144MP0003656_abnormal_erythrocyte_physiolo0.54931645
145MP0008770_decreased_survivor_rate0.54886279
146MP0004043_abnormal_pH_regulation0.53520464
147MP0005584_abnormal_enzyme/coenzyme_acti0.52875243
148MP0003984_embryonic_growth_retardation0.51051929
149MP0005167_abnormal_blood-brain_barrier0.49767053
150MP0005535_abnormal_body_temperature0.46584129
151MP0005334_abnormal_fat_pad0.46322124

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.02757515
2Focal motor seizures (HP:0011153)4.77461436
3Muscle fiber inclusion bodies (HP:0100299)4.66085422
4Febrile seizures (HP:0002373)4.59551545
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.49196442
6Nemaline bodies (HP:0003798)3.98948801
7Epileptic encephalopathy (HP:0200134)3.89700316
8Muscle hypertrophy of the lower extremities (HP:0008968)3.75829239
9Fetal akinesia sequence (HP:0001989)3.61511276
10Exercise-induced muscle cramps (HP:0003710)3.60059445
11Cerebellar dysplasia (HP:0007033)3.57709112
12Calf muscle hypertrophy (HP:0008981)3.55037317
13Abnormality of the nasal septum (HP:0000419)3.54353780
14Abnormality of the ischium (HP:0003174)3.46488127
15Atonic seizures (HP:0010819)3.30928668
16Abnormal hair whorl (HP:0010721)3.26568952
17Hyporeflexia of lower limbs (HP:0002600)3.21148148
18Abnormality of the calf musculature (HP:0001430)3.19460009
19Broad-based gait (HP:0002136)3.18087928
20Type 1 muscle fiber predominance (HP:0003803)3.17114721
21Frequent falls (HP:0002359)3.14252075
22Calcaneovalgus deformity (HP:0001848)3.10235589
23Protruding tongue (HP:0010808)3.02978453
24Subaortic stenosis (HP:0001682)2.96266596
25Abnormality of the left ventricular outflow tract (HP:0011103)2.96266596
26Distal arthrogryposis (HP:0005684)2.94745784
27Myopathic facies (HP:0002058)2.91860573
28Focal seizures (HP:0007359)2.89271912
29Hyperventilation (HP:0002883)2.84583864
30Submucous cleft hard palate (HP:0000176)2.75786837
31Abnormal finger flexion creases (HP:0006143)2.74340001
32EMG: myopathic abnormalities (HP:0003458)2.72076071
33Deformed tarsal bones (HP:0008119)2.68730139
34Absence seizures (HP:0002121)2.67972538
35Short chin (HP:0000331)2.66089213
36Long clavicles (HP:0000890)2.64067984
37Subacute progressive viral hepatitis (HP:0006572)2.58902361
38Hyperkalemia (HP:0002153)2.55530702
39Increased circulating renin level (HP:0000848)2.53130289
40Weak cry (HP:0001612)2.52929522
41Poor eye contact (HP:0000817)2.52538426
42Myotonia (HP:0002486)2.51856873
43Abnormality of alanine metabolism (HP:0010916)2.48634323
44Hyperalaninemia (HP:0003348)2.48634323
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48634323
46Gaze-evoked nystagmus (HP:0000640)2.41906953
47Bundle branch block (HP:0011710)2.41814878
48Progressive cerebellar ataxia (HP:0002073)2.39175903
49Abnormality of B cell number (HP:0010975)2.37955925
50B lymphocytopenia (HP:0010976)2.37955925
51Abnormality of the calcaneus (HP:0008364)2.36402556
52Ulnar deviation of the wrist (HP:0003049)2.34346235
53Generalized muscle weakness (HP:0003324)2.33357689
54Oligomenorrhea (HP:0000876)2.31197827
55Lower limb amyotrophy (HP:0007210)2.29799596
56Type 2 muscle fiber atrophy (HP:0003554)2.28974023
57Nonprogressive disorder (HP:0003680)2.28248413
58Visual hallucinations (HP:0002367)2.27011315
59Papillary thyroid carcinoma (HP:0002895)2.26893168
60Alkalosis (HP:0001948)2.26631263
61Distal lower limb amyotrophy (HP:0008944)2.25760588
62Shoulder girdle muscle weakness (HP:0003547)2.24232871
63Bicuspid aortic valve (HP:0001647)2.23877840
64Round ear (HP:0100830)2.23380678
65Abnormality of skeletal muscle fiber size (HP:0012084)2.22093644
66Hypokalemic alkalosis (HP:0001949)2.21353119
67Difficulty running (HP:0009046)2.21213212
68Scanning speech (HP:0002168)2.18680716
69Dysmetric saccades (HP:0000641)2.14571048
70Broad face (HP:0000283)2.13022850
71Dislocated radial head (HP:0003083)2.11879102
72Neoplasm of the heart (HP:0100544)2.11860181
73Abnormality of the radial head (HP:0003995)2.10921760
74Myoglobinuria (HP:0002913)2.10554028
75Truncal obesity (HP:0001956)2.09385831
76Ulnar deviation of finger (HP:0009465)2.08674716
77Abnormality of the neuromuscular junction (HP:0003398)2.05913449
78Fatigable weakness (HP:0003473)2.05913449
79Thickened helices (HP:0000391)2.05684571
80Dialeptic seizures (HP:0011146)2.04463100
81EMG: neuropathic changes (HP:0003445)2.00740365
82Sudden death (HP:0001699)2.00388282
83Pelvic girdle muscle weakness (HP:0003749)2.00311971
84Heterotopia (HP:0002282)2.00064079
85Absent speech (HP:0001344)1.99936019
86Impaired vibration sensation in the lower limbs (HP:0002166)1.99918264
87Menstrual irregularities (HP:0000858)1.99885342
88Prolonged QT interval (HP:0001657)1.99856163
89Supraventricular tachycardia (HP:0004755)1.99791305
90Malignant hyperthermia (HP:0002047)1.99347000
91Increased variability in muscle fiber diameter (HP:0003557)1.98933197
92Abnormal social behavior (HP:0012433)1.98905094
93Impaired social interactions (HP:0000735)1.98905094
94Primary atrial arrhythmia (HP:0001692)1.97884600
95* Blue irides (HP:0000635)1.96649672
96Abnormal EKG (HP:0003115)1.95725006
97Muscular dystrophy (HP:0003560)1.95390786
98Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.95218084
99Cystic hygroma (HP:0000476)1.94544422
100Abnormality of the musculature of the pelvis (HP:0001469)1.93564461
101Abnormality of the hip-girdle musculature (HP:0001445)1.93564461
102Bulbar palsy (HP:0001283)1.92646061
103Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.92128857
104Urinary bladder sphincter dysfunction (HP:0002839)1.91966237
105Polyphagia (HP:0002591)1.90785967
106Supraventricular arrhythmia (HP:0005115)1.90574048
107Muscle stiffness (HP:0003552)1.90474084
108Hypoplasia of the iris (HP:0007676)1.90433614
109Widely spaced teeth (HP:0000687)1.90431348
110Atrial fibrillation (HP:0005110)1.90072843
111Hypoplastic ischia (HP:0003175)1.89928006
112Hypoventilation (HP:0002791)1.89487713
113Centrally nucleated skeletal muscle fibers (HP:0003687)1.88694801
114Abnormality of the labia minora (HP:0012880)1.88269435
115Prominent nose (HP:0000448)1.88089498
116Generalized tonic-clonic seizures (HP:0002069)1.87832230
117Narrow nasal bridge (HP:0000446)1.87248968
118Drooling (HP:0002307)1.86741927
119Excessive salivation (HP:0003781)1.86741927
120Aortic aneurysm (HP:0004942)1.85573165
121Muscle fiber splitting (HP:0003555)1.84523560
122Abnormal auditory evoked potentials (HP:0006958)1.83970277
123Lipoatrophy (HP:0100578)1.83628177
124Neuroendocrine neoplasm (HP:0100634)1.82765843
125Muscle fiber atrophy (HP:0100295)1.82595860
126Knee flexion contracture (HP:0006380)1.80758089
127Increased connective tissue (HP:0009025)1.80611407
128Truncal ataxia (HP:0002078)1.78449238
129* Fair hair (HP:0002286)1.78096876
130Tented upper lip vermilion (HP:0010804)1.76448810
131Abnormality of the epiphyses of the hand (HP:0005924)1.76110681
132Genetic anticipation (HP:0003743)1.75528787
133Rimmed vacuoles (HP:0003805)1.74210158
134Heterochromia iridis (HP:0001100)1.72962933
135Reduced subcutaneous adipose tissue (HP:0003758)1.72907972
136Fatigue (HP:0012378)1.72597618
137Hypoplastic nipples (HP:0002557)1.72321991
138Neck muscle weakness (HP:0000467)1.71284377
139Volvulus (HP:0002580)1.69439943
140Rhabdomyolysis (HP:0003201)1.69289231
141Left ventricular hypertrophy (HP:0001712)1.68724761
142Absent phalangeal crease (HP:0006109)1.68321437
143Steppage gait (HP:0003376)1.68055083
144Hypoplasia of the pons (HP:0012110)1.67150363
145Urinary urgency (HP:0000012)1.67080699
146Thyroiditis (HP:0100646)1.66754215
147Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.65559687
148Hypothermia (HP:0002045)1.64866439
149Abnormal eating behavior (HP:0100738)1.63621257
150Cubitus valgus (HP:0002967)1.63113939
151Osteolytic defects of the hand bones (HP:0009699)1.62882506
152Osteolytic defects of the phalanges of the hand (HP:0009771)1.62882506
153Failure to thrive in infancy (HP:0001531)1.62768594
154Abnormality of potassium homeostasis (HP:0011042)1.62350442
155Dilated cardiomyopathy (HP:0001644)1.62260088
156Growth hormone deficiency (HP:0000824)1.61532913
157Areflexia of lower limbs (HP:0002522)1.59790559
158Stereotypic behavior (HP:0000733)1.57729655

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.82193561
2SIK34.67412233
3STK393.53554846
4MAP2K73.49937903
5MAP3K123.30147050
6FRK3.23167296
7OBSCN3.11124401
8MAP3K42.96277508
9NTRK22.53439892
10WNK42.50001996
11MARK12.35368092
12OXSR12.24096300
13NTRK32.23015147
14TXK2.16692609
15LATS12.13921568
16PHKG22.10621890
17PHKG12.10621890
18CDK191.92386703
19BRD41.89725605
20DAPK11.89379123
21MAPK131.81976848
22KSR11.73489264
23TNIK1.64235756
24PRPF4B1.58374369
25MST1R1.58165778
26NEK61.57204546
27MUSK1.56566463
28EIF2AK31.51891062
29TSSK61.49811000
30SGK21.48755825
31MAP2K41.44324837
32ACVR1B1.27504795
33MINK11.25799784
34NLK1.24655991
35TTN1.22953030
36EEF2K1.21457063
37MAP3K71.20621835
38DAPK21.19787060
39ERBB31.19618040
40BMPR1B1.19046652
41AKT31.18123001
42PINK11.11378132
43STK38L1.10520110
44CCNB11.10360526
45STK241.09963274
46PLK21.08149014
47CAMKK21.07708336
48NME11.05164212
49MAPK111.00038668
50DMPK0.96201490
51CDK120.96164532
52FGFR30.92259291
53PDK30.92212956
54PDK40.92212956
55SGK30.91602152
56LATS20.88999717
57CDK80.88122267
58NEK10.85244638
59EPHA40.84887741
60VRK10.84220255
61PRKAA20.82749634
62CDK30.80120844
63MAPKAPK30.78454587
64CAMK10.78001250
65ZAK0.77613784
66MAPK120.74663476
67PDGFRB0.73828482
68PIK3CA0.73490389
69SIK20.73064009
70MET0.73027314
71CAMK40.71924056
72MELK0.70846259
73TEC0.69369371
74MAP3K60.68068980
75MARK20.67391962
76RPS6KB20.67348944
77SGK4940.67246574
78SGK2230.67246574
79TLK10.66998771
80RPS6KB10.66101075
81FER0.65911214
82BCR0.64623772
83EIF2AK20.64567599
84TGFBR20.64175138
85TAOK30.63648595
86TAOK20.63541635
87BRSK20.63121213
88CDK50.63084845
89FES0.62387500
90UHMK10.61653486
91EPHA30.58264472
92IRAK40.56663688
93MARK30.55768579
94SGK10.54867298
95MTOR0.54461974
96NTRK10.52704180
97MAP4K20.51169829
98CDK180.47638801
99CAMK2A0.46485334
100MAP3K140.46344860
101PDK20.46095014
102TRPM70.45936632
103PDK10.45754136
104MAPK100.45616898
105STK30.44965118
106PIK3CG0.43912568
107PRKCG0.43844507
108MAP2K60.43591578
109ITK0.43035141
110CAMK2B0.43033207
111ADRBK20.42698625
112CAMKK10.42350362
113PRKAA10.41828094
114ICK0.41443453
115GRK50.40234691
116JAK10.40012719
117PIM10.39524282
118RAF10.38460844
119TNK20.37969729
120CDK60.37867121
121TAOK10.37711042
122MYLK0.37620729
123INSRR0.37559601
124CAMK1G0.37253127
125PRKCH0.37180386
126MAPKAPK50.37020678
127BMPR20.36636670
128RET0.36569369
129MKNK20.36564940
130WNK10.36313378
131CAMK1D0.35528825
132SYK0.35446622
133MAP4K10.34758268
134STK380.33453721
135MAPK70.33352743
136RPS6KA30.32907578
137STK110.32760111
138MAPK40.32239978
139GSK3A0.32192253
140PRKCE0.32086037
141CAMK2D0.32006217
142LCK0.30537669
143IRAK20.30504367
144CHUK0.29894952
145FGFR20.29602109
146RPS6KA50.29589100
147MAPK80.28450419
148MAP2K10.27932239
149TIE10.27357911
150TGFBR10.26910376

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.90676888
2Nicotine addiction_Homo sapiens_hsa050332.78790939
3Synaptic vesicle cycle_Homo sapiens_hsa047212.29239262
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.26929231
5Olfactory transduction_Homo sapiens_hsa047402.12667891
6Circadian entrainment_Homo sapiens_hsa047132.09932089
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99592168
8* Morphine addiction_Homo sapiens_hsa050321.95768569
9Dilated cardiomyopathy_Homo sapiens_hsa054141.72660156
10Dorso-ventral axis formation_Homo sapiens_hsa043201.72496184
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.66025733
12Calcium signaling pathway_Homo sapiens_hsa040201.60543391
13GABAergic synapse_Homo sapiens_hsa047271.58324989
14ABC transporters_Homo sapiens_hsa020101.47860080
15Arginine biosynthesis_Homo sapiens_hsa002201.46782599
16Small cell lung cancer_Homo sapiens_hsa052221.45918323
17Dopaminergic synapse_Homo sapiens_hsa047281.44889265
18Insulin secretion_Homo sapiens_hsa049111.44615718
19Oxytocin signaling pathway_Homo sapiens_hsa049211.44511656
20Long-term potentiation_Homo sapiens_hsa047201.43774894
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42896590
22Glutamatergic synapse_Homo sapiens_hsa047241.42482178
23Amphetamine addiction_Homo sapiens_hsa050311.39940356
24Renin secretion_Homo sapiens_hsa049241.34415790
25Taste transduction_Homo sapiens_hsa047421.33543256
26Collecting duct acid secretion_Homo sapiens_hsa049661.31737822
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31198360
28Cholinergic synapse_Homo sapiens_hsa047251.31044496
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29069467
30Salivary secretion_Homo sapiens_hsa049701.27323015
31Circadian rhythm_Homo sapiens_hsa047101.27275418
32TGF-beta signaling pathway_Homo sapiens_hsa043501.21166595
33Long-term depression_Homo sapiens_hsa047301.20430830
34Serotonergic synapse_Homo sapiens_hsa047261.18778203
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18495926
36Viral myocarditis_Homo sapiens_hsa054161.16698062
37Gastric acid secretion_Homo sapiens_hsa049711.13295367
38Non-small cell lung cancer_Homo sapiens_hsa052231.12969501
39ErbB signaling pathway_Homo sapiens_hsa040121.12311528
40Focal adhesion_Homo sapiens_hsa045101.10037968
41Adherens junction_Homo sapiens_hsa045201.09634273
42Adipocytokine signaling pathway_Homo sapiens_hsa049201.09252756
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08694344
44Renal cell carcinoma_Homo sapiens_hsa052111.07707934
45MAPK signaling pathway_Homo sapiens_hsa040101.06840434
46Primary immunodeficiency_Homo sapiens_hsa053401.05638317
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05111860
48Pancreatic cancer_Homo sapiens_hsa052121.04953849
49Cardiac muscle contraction_Homo sapiens_hsa042601.04037638
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.04020331
51T cell receptor signaling pathway_Homo sapiens_hsa046601.03465912
52Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01766250
53Insulin signaling pathway_Homo sapiens_hsa049100.99435907
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99062729
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98674561
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98527689
57Regulation of autophagy_Homo sapiens_hsa041400.98447322
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97986756
59Alcoholism_Homo sapiens_hsa050340.97888725
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97631545
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97228744
62Type II diabetes mellitus_Homo sapiens_hsa049300.95958363
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93331544
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91354238
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89498983
66* cAMP signaling pathway_Homo sapiens_hsa040240.88518157
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87952279
68GnRH signaling pathway_Homo sapiens_hsa049120.86481565
69Vibrio cholerae infection_Homo sapiens_hsa051100.85599582
70Cocaine addiction_Homo sapiens_hsa050300.85366859
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83586475
72Glucagon signaling pathway_Homo sapiens_hsa049220.82246547
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.82179937
74Colorectal cancer_Homo sapiens_hsa052100.81622901
75Chronic myeloid leukemia_Homo sapiens_hsa052200.80504389
76MicroRNAs in cancer_Homo sapiens_hsa052060.80248022
77Axon guidance_Homo sapiens_hsa043600.80204662
78Systemic lupus erythematosus_Homo sapiens_hsa053220.79345696
79Gap junction_Homo sapiens_hsa045400.78365467
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78110019
81Glioma_Homo sapiens_hsa052140.76861092
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75232195
83ECM-receptor interaction_Homo sapiens_hsa045120.74614025
84Fatty acid biosynthesis_Homo sapiens_hsa000610.74184148
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73194254
86VEGF signaling pathway_Homo sapiens_hsa043700.73083609
87Ovarian steroidogenesis_Homo sapiens_hsa049130.71272528
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70375676
89Type I diabetes mellitus_Homo sapiens_hsa049400.69330835
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.68320787
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.67821627
92Inositol phosphate metabolism_Homo sapiens_hsa005620.67222908
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66312460
94FoxO signaling pathway_Homo sapiens_hsa040680.65159422
95Amoebiasis_Homo sapiens_hsa051460.64785608
96Prostate cancer_Homo sapiens_hsa052150.64746360
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63891356
98Acute myeloid leukemia_Homo sapiens_hsa052210.60741055
99Chemokine signaling pathway_Homo sapiens_hsa040620.60131927
100Lysine degradation_Homo sapiens_hsa003100.59604155
101Pathways in cancer_Homo sapiens_hsa052000.59239038
102AMPK signaling pathway_Homo sapiens_hsa041520.58587223
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58116750
104Platelet activation_Homo sapiens_hsa046110.57902440
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57759971
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.56738300
107Wnt signaling pathway_Homo sapiens_hsa043100.56484360
108mTOR signaling pathway_Homo sapiens_hsa041500.56032967
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55674329
110Endometrial cancer_Homo sapiens_hsa052130.55578831
111Hedgehog signaling pathway_Homo sapiens_hsa043400.55547757
112Measles_Homo sapiens_hsa051620.55508486
113Allograft rejection_Homo sapiens_hsa053300.55482440
114Hippo signaling pathway_Homo sapiens_hsa043900.55105931
115Ras signaling pathway_Homo sapiens_hsa040140.55030358
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54664656
117Proteoglycans in cancer_Homo sapiens_hsa052050.53872586
118Prolactin signaling pathway_Homo sapiens_hsa049170.53475052
119HIF-1 signaling pathway_Homo sapiens_hsa040660.51069680
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51007571
121Rheumatoid arthritis_Homo sapiens_hsa053230.50462170
122N-Glycan biosynthesis_Homo sapiens_hsa005100.50009720
123TNF signaling pathway_Homo sapiens_hsa046680.49677171
124Melanogenesis_Homo sapiens_hsa049160.49401615
125Osteoclast differentiation_Homo sapiens_hsa043800.48636459
126Estrogen signaling pathway_Homo sapiens_hsa049150.48544964
127Viral carcinogenesis_Homo sapiens_hsa052030.48207095
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47918779
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46989330
130B cell receptor signaling pathway_Homo sapiens_hsa046620.46691831
131Rap1 signaling pathway_Homo sapiens_hsa040150.46419719
132Hepatitis B_Homo sapiens_hsa051610.45843331
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45576632
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44585429
135Autoimmune thyroid disease_Homo sapiens_hsa053200.44239221
136Phagosome_Homo sapiens_hsa041450.43983554
137Choline metabolism in cancer_Homo sapiens_hsa052310.43735018
138Insulin resistance_Homo sapiens_hsa049310.43608199
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43535290

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