PDE4DIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)8.01761875
2actin-myosin filament sliding (GO:0033275)7.25878275
3muscle filament sliding (GO:0030049)7.25878275
4cardiac myofibril assembly (GO:0055003)6.98410976
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.87640069
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.82944099
7myofibril assembly (GO:0030239)6.78810942
8plasma membrane repair (GO:0001778)6.55620917
9regulation of skeletal muscle contraction (GO:0014819)6.53594937
10regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.35471015
11negative regulation of potassium ion transmembrane transport (GO:1901380)6.17235152
12sarcoplasmic reticulum calcium ion transport (GO:0070296)6.14552710
13regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.08376291
14actin-mediated cell contraction (GO:0070252)6.00299484
15cardiac muscle contraction (GO:0060048)5.86988124
16regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.46408941
17regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.41942724
18regulation of relaxation of muscle (GO:1901077)5.37373086
19striated muscle contraction (GO:0006941)5.26478407
20regulation of actin filament-based movement (GO:1903115)5.22620147
21actomyosin structure organization (GO:0031032)5.21148960
22regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.17422382
23cardiac muscle cell development (GO:0055013)5.16501715
24tricarboxylic acid cycle (GO:0006099)5.13852871
25carnitine shuttle (GO:0006853)5.10004294
26regulation of cell communication by electrical coupling (GO:0010649)5.01566304
27ventricular cardiac muscle cell action potential (GO:0086005)5.00156756
28cardiac cell development (GO:0055006)4.82949846
29cardiac muscle hypertrophy (GO:0003300)4.73437835
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.70285596
31regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.63151711
32skeletal muscle contraction (GO:0003009)4.62366677
33adult heart development (GO:0007512)4.62130790
34actin filament-based movement (GO:0030048)4.58666422
35striated muscle hypertrophy (GO:0014897)4.56487702
36cell communication involved in cardiac conduction (GO:0086065)4.52205398
37regulation of membrane repolarization (GO:0060306)4.49226719
38regulation of striated muscle contraction (GO:0006942)4.45274806
39response to muscle activity (GO:0014850)4.43196628
40cardiac muscle tissue morphogenesis (GO:0055008)4.42625729
41fatty acid transmembrane transport (GO:1902001)4.40010199
42bundle of His cell to Purkinje myocyte communication (GO:0086069)4.39362128
43response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.37783378
44regulation of sarcomere organization (GO:0060297)4.26996852
45regulation of acyl-CoA biosynthetic process (GO:0050812)4.23617853
46cell communication by electrical coupling (GO:0010644)4.12486729
47muscle tissue morphogenesis (GO:0060415)4.04823990
48regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.04190453
49positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.03485415
50ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.02483885
51muscle hypertrophy (GO:0014896)3.98695257
52creatine metabolic process (GO:0006600)3.96014137
53regulation of coenzyme metabolic process (GO:0051196)3.83762458
54regulation of cofactor metabolic process (GO:0051193)3.83762458
55heart trabecula formation (GO:0060347)3.83640809
56carnitine transmembrane transport (GO:1902603)3.79555152
57regulation of calcium ion transmembrane transport (GO:1903169)3.77360156
58regulation of calcium ion transmembrane transporter activity (GO:1901019)3.77360156
59regulation of the force of heart contraction (GO:0002026)3.76863816
60cardiac muscle cell action potential (GO:0086001)3.74074676
61response to inactivity (GO:0014854)3.73991586
62skeletal muscle adaptation (GO:0043501)3.72909670
63muscle contraction (GO:0006936)3.72196053
64cardiac muscle cell action potential involved in contraction (GO:0086002)3.70269109
65muscle cell cellular homeostasis (GO:0046716)3.66933331
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63122287
67regulation of cardiac muscle contraction (GO:0055117)3.60545172
68heart process (GO:0003015)3.60140204
69heart contraction (GO:0060047)3.60140204
70regulation of heart rate (GO:0002027)3.52987800
71regulation of cardiac muscle cell contraction (GO:0086004)3.52066608
72positive regulation of cation channel activity (GO:2001259)3.51287400
73negative regulation of protein localization to cell surface (GO:2000009)3.49925470
742-oxoglutarate metabolic process (GO:0006103)3.49670871
75negative regulation of potassium ion transport (GO:0043267)3.49655186
76amino-acid betaine transport (GO:0015838)3.49080336
77carnitine transport (GO:0015879)3.49080336
78relaxation of cardiac muscle (GO:0055119)3.46500624
79cardiac muscle hypertrophy in response to stress (GO:0014898)3.46459109
80muscle hypertrophy in response to stress (GO:0003299)3.46459109
81cardiac muscle adaptation (GO:0014887)3.46459109
82muscle system process (GO:0003012)3.45436124
83striated muscle adaptation (GO:0014888)3.44658830
84cardiac conduction (GO:0061337)3.41792450
85detection of calcium ion (GO:0005513)3.40177924
86NADH metabolic process (GO:0006734)3.37257850
87striated muscle cell development (GO:0055002)3.36620216
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.36301545
89glycogen catabolic process (GO:0005980)3.29658847
90myotube cell development (GO:0014904)3.29621654
91skeletal muscle fiber development (GO:0048741)3.28935490
92regulation of heart rate by cardiac conduction (GO:0086091)3.28733444
93regulation of heart contraction (GO:0008016)3.27606979
94relaxation of muscle (GO:0090075)3.27040660
95response to epinephrine (GO:0071871)3.21128045
96regulation of ATPase activity (GO:0043462)3.19274552
97regulation of ATP catabolic process (GO:1903289)3.19274552
98response to caffeine (GO:0031000)3.18727628
99cellular response to epinephrine stimulus (GO:0071872)3.18120463
100positive regulation of heart rate (GO:0010460)3.18030711
101regulation of sulfur metabolic process (GO:0042762)3.14217007
102muscle fiber development (GO:0048747)3.12499491
103regulation of sequestering of triglyceride (GO:0010889)3.11925574
104aspartate family amino acid catabolic process (GO:0009068)3.10565141
105muscle adaptation (GO:0043500)3.09455659
106glucan catabolic process (GO:0009251)3.09361041
107positive regulation of heart contraction (GO:0045823)3.07457300
108muscle atrophy (GO:0014889)3.01518411
109striated muscle atrophy (GO:0014891)3.01431045
110regulation of muscle contraction (GO:0006937)2.99311104
111regulation of cation channel activity (GO:2001257)2.95911945
112negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.95024411
113negative regulation of calcium ion transmembrane transport (GO:1903170)2.93432089
114negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.93432089
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.92829833
116skeletal muscle tissue development (GO:0007519)2.89142696
117regulation of muscle system process (GO:0090257)2.88071263
118membrane depolarization during action potential (GO:0086010)2.77530240
119macroautophagy (GO:0016236)2.73068593
120neuronal action potential propagation (GO:0019227)2.66347310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.85083516
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.81460890
3EP300_21415370_ChIP-Seq_HL-1_Mouse3.39292386
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.00113282
5TBX20_22328084_ChIP-Seq_HEART_Mouse2.85587961
6TBX20_22080862_ChIP-Seq_HEART_Mouse2.85587961
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.46706436
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37364602
9ZNF263_19887448_ChIP-Seq_K562_Human2.20601954
10DROSHA_22980978_ChIP-Seq_HELA_Human2.15144972
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09989513
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08840808
13MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.01536639
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.99022385
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93412917
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.89696384
17* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83144856
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.81991967
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73969550
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72242944
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71431367
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.57166445
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55683525
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.54622366
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.51709581
26* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51273579
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51056685
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51056685
29* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48724851
30CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48292646
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46712744
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46607033
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45593122
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.45212194
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43703347
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.39718133
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36586614
38* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36526941
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36000319
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36000319
41CTCF_27219007_Chip-Seq_Bcells_Human1.35990426
42* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35482136
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32731335
44* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32535621
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.32282232
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32117677
47ZNF274_21170338_ChIP-Seq_K562_Hela1.29975574
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28719623
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24812428
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24448854
51GATA4_21415370_ChIP-Seq_HL-1_Mouse1.23678004
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22768087
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22634184
54IGF1R_20145208_ChIP-Seq_DFB_Human1.21392350
55* LXR_22158963_ChIP-Seq_LIVER_Mouse1.20199405
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18943180
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18626097
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16945524
59TP53_16413492_ChIP-PET_HCT116_Human1.16480101
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14862459
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14607854
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14239031
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14187892
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.11565842
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11413495
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11255662
67* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11146667
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09686241
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08413487
70* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08224061
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07337179
72TCF4_23295773_ChIP-Seq_U87_Human1.07017187
73* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06681410
74* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06339052
75* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06311358
76PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06255432
77AR_21572438_ChIP-Seq_LNCaP_Human1.06147612
78VDR_22108803_ChIP-Seq_LS180_Human1.05492700
79* STAT3_23295773_ChIP-Seq_U87_Human1.05303340
80SMAD3_21741376_ChIP-Seq_HESCs_Human1.05106731
81CJUN_26792858_Chip-Seq_BT549_Human1.04813697
82* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04762067
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.03974832
84* SMAD4_21741376_ChIP-Seq_HESCs_Human1.03885388
85* KDM2B_26808549_Chip-Seq_K562_Human1.03658410
86* FOXA2_19822575_ChIP-Seq_HepG2_Human1.03558905
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03101823
88RXR_22158963_ChIP-Seq_LIVER_Mouse1.02376737
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00881528
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00876338
91CLOCK_20551151_ChIP-Seq_293T_Human1.00122864
92* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99909583
93* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99526378
94* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99202092
95GBX2_23144817_ChIP-Seq_PC3_Human0.98480033
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98144677
97* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98027014
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97923284
99AHR_22903824_ChIP-Seq_MCF-7_Human0.97460517
100ISL1_27105846_Chip-Seq_CPCs_Mouse0.97409726
101ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96922426
102ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96335689
103EZH2_27294783_Chip-Seq_NPCs_Mouse0.95815805
104TRIM28_21343339_ChIP-Seq_HEK293_Human0.95386387
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94997181
106YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94562546
107SMAD3_21741376_ChIP-Seq_EPCs_Human0.94513611
108TP63_22573176_ChIP-Seq_HFKS_Human0.93396974
109SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92280318
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91377489
111* AR_19668381_ChIP-Seq_PC3_Human0.90814271
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90514104
113SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90405077
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90205852
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90061365
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89846401
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89644164
118TAF15_26573619_Chip-Seq_HEK293_Human0.89469405
119* REST_18959480_ChIP-ChIP_MESCs_Mouse0.89351477
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.89075276
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88322840
122BCAT_22108803_ChIP-Seq_LS180_Human0.88102784
123CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87887110
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.87877677
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86926594
126* SMAD4_21799915_ChIP-Seq_A2780_Human0.86801438
127NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86286431
128* KDM2B_26808549_Chip-Seq_DND41_Human0.85810309
129* LXR_22292898_ChIP-Seq_THP-1_Human0.85476723
130REST_21632747_ChIP-Seq_MESCs_Mouse0.84387809
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83764535
132OCT4_20526341_ChIP-Seq_ESCs_Human0.83104088
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.82850913
134* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81692890
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81468293
136GATA1_22025678_ChIP-Seq_K562_Human0.81387465
137KLF4_19829295_ChIP-Seq_ESCs_Human0.81221592
138EED_16625203_ChIP-ChIP_MESCs_Mouse0.81182614
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80850391
140SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79930290
141GATA1_19941826_ChIP-Seq_K562_Human0.78962341
142FOXH1_21741376_ChIP-Seq_ESCs_Human0.78103438
143* RUNX1_27514584_Chip-Seq_MCF-7_Human0.77978281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.56214437
2MP0003646_muscle_fatigue5.75703909
3MP0000751_myopathy5.47245691
4MP0004084_abnormal_cardiac_muscle4.78395252
5MP0000749_muscle_degeneration4.31710992
6MP0004215_abnormal_myocardial_fiber4.23990675
7MP0004036_abnormal_muscle_relaxation4.08617224
8MP0004145_abnormal_muscle_electrophysio3.46782242
9MP0005330_cardiomyopathy3.42718968
10MP0004087_abnormal_muscle_fiber3.11583492
11MP0005620_abnormal_muscle_contractility2.79813294
12MP0002106_abnormal_muscle_physiology2.78377396
13MP0004130_abnormal_muscle_cell2.75533612
14MP0000750_abnormal_muscle_regeneration2.73547207
15MP0002972_abnormal_cardiac_muscle2.72660466
16MP0002269_muscular_atrophy2.62068539
17MP0003137_abnormal_impulse_conducting2.61046163
18MP0000747_muscle_weakness2.55855021
19MP0008775_abnormal_heart_ventricle2.39151009
20MP0000759_abnormal_skeletal_muscle2.30476001
21MP0005369_muscle_phenotype2.29828297
22MP0004484_altered_response_of2.24815295
23MP0010630_abnormal_cardiac_muscle2.19073225
24MP0005385_cardiovascular_system_phenoty2.16477941
25MP0001544_abnormal_cardiovascular_syste2.16477941
26MP0005451_abnormal_body_composition2.14738977
27MP0006138_congestive_heart_failure1.95635512
28MP0004233_abnormal_muscle_weight1.90709456
29MP0004085_abnormal_heartbeat1.90590330
30MP0004510_myositis1.85047834
31MP0003221_abnormal_cardiomyocyte_apopto1.63055303
32MP0003828_pulmonary_edema1.49030317
33MP0006036_abnormal_mitochondrial_physio1.49025372
34MP0005666_abnormal_adipose_tissue1.46887644
35MP0002332_abnormal_exercise_endurance1.40406879
36MP0002127_abnormal_cardiovascular_syste1.33750740
37MP0005670_abnormal_white_adipose1.33144325
38MP0003950_abnormal_plasma_membrane1.31933198
39MP0002108_abnormal_muscle_morphology1.17263680
40MP0005167_abnormal_blood-brain_barrier1.17049088
41MP0002234_abnormal_pharynx_morphology1.16596038
42MP0003879_abnormal_hair_cell1.13969332
43MP0009840_abnormal_foam_cell1.13392387
44MP0004185_abnormal_adipocyte_glucose1.13321114
45MP0005375_adipose_tissue_phenotype1.06792426
46MP0002909_abnormal_adrenal_gland1.05928939
47MP0003690_abnormal_glial_cell1.05776628
48MP0001501_abnormal_sleep_pattern1.03122606
49MP0009780_abnormal_chondrocyte_physiolo1.00892083
50MP0002064_seizures0.96143438
51MP0004859_abnormal_synaptic_plasticity0.95964988
52MP0004043_abnormal_pH_regulation0.95312180
53MP0004270_analgesia0.95211901
54MP0000013_abnormal_adipose_tissue0.95172966
55MP0006035_abnormal_mitochondrial_morpho0.92728965
56MP0000266_abnormal_heart_morphology0.92566138
57MP0000733_abnormal_muscle_development0.85083336
58MP0005423_abnormal_somatic_nervous0.84246209
59MP0002822_catalepsy0.81030399
60MP0002734_abnormal_mechanical_nocicepti0.79173316
61MP0005165_increased_susceptibility_to0.78425944
62MP0000230_abnormal_systemic_arterial0.78015823
63MP0000920_abnormal_myelination0.77995913
64MP0000343_altered_response_to0.76291417
65MP0008004_abnormal_stomach_pH0.75300921
66MP0005266_abnormal_metabolism0.75235052
67MP0010368_abnormal_lymphatic_system0.75151073
68MP0003633_abnormal_nervous_system0.74717023
69MP0001984_abnormal_olfaction0.74549357
70MP0001661_extended_life_span0.73895149
71MP0008961_abnormal_basal_metabolism0.73154829
72MP0003705_abnormal_hypodermis_morpholog0.73014334
73MP0003567_abnormal_fetal_cardiomyocyte0.72325092
74MP0002971_abnormal_brown_adipose0.71959990
75MP0003303_peritoneal_inflammation0.71527511
76MP0000003_abnormal_adipose_tissue0.70997288
77MP0005058_abnormal_lysosome_morphology0.70975214
78MP0001486_abnormal_startle_reflex0.67143779
79MP0005187_abnormal_penis_morphology0.66715161
80MP0005623_abnormal_meninges_morphology0.65685803
81MP0002078_abnormal_glucose_homeostasis0.65635794
82MP0003279_aneurysm0.60773652
83MP0003656_abnormal_erythrocyte_physiolo0.59874744
84MP0002128_abnormal_blood_circulation0.59104984
85MP0003045_fibrosis0.58074886
86MP0008569_lethality_at_weaning0.57609606
87MP0005535_abnormal_body_temperature0.54967264
88MP0003634_abnormal_glial_cell0.54743804
89MP0005166_decreased_susceptibility_to0.54367525
90MP0004924_abnormal_behavior0.54088261
91MP0005386_behavior/neurological_phenoty0.54088261
92MP0000604_amyloidosis0.51364992
93MP0003631_nervous_system_phenotype0.51241478
94MP0003075_altered_response_to0.51033197
95MP0002067_abnormal_sensory_capabilities0.50574844
96MP0005595_abnormal_vascular_smooth0.50310695
97MP0003635_abnormal_synaptic_transmissio0.49428287
98MP0002572_abnormal_emotion/affect_behav0.48411382
99MP0001299_abnormal_eye_distance/0.48368545
100MP0003195_calcinosis0.46530041
101MP0002735_abnormal_chemical_nociception0.45038969
102MP0005319_abnormal_enzyme/_coenzyme0.43202992
103MP0005275_abnormal_skin_tensile0.43135328
104MP0005334_abnormal_fat_pad0.42335464
105MP0003806_abnormal_nucleotide_metabolis0.42041664
106MP0002118_abnormal_lipid_homeostasis0.37822543
107MP0004147_increased_porphyrin_level0.35956809
108MP0003948_abnormal_gas_homeostasis0.34844625
109MP0005085_abnormal_gallbladder_physiolo0.34663034
110MP0003329_amyloid_beta_deposits0.34132465
111MP0000767_abnormal_smooth_muscle0.32678616
112MP0004858_abnormal_nervous_system0.32550684
113MP0003566_abnormal_cell_adhesion0.32333363
114MP0002272_abnormal_nervous_system0.32083378
115MP0009745_abnormal_behavioral_response0.31956728
116MP0001440_abnormal_grooming_behavior0.31813638
117MP0003252_abnormal_bile_duct0.31582563
118MP0009046_muscle_twitch0.31398022
119MP0001879_abnormal_lymphatic_vessel0.31120730
120MP0002063_abnormal_learning/memory/cond0.29831884
121MP0000579_abnormal_nail_morphology0.29086140
122MP0002896_abnormal_bone_mineralization0.28730142
123MP0008874_decreased_physiological_sensi0.28070756
124MP0008438_abnormal_cutaneous_collagen0.27771240
125MP0005584_abnormal_enzyme/coenzyme_acti0.27483991
126MP0002066_abnormal_motor_capabilities/c0.27370137
127MP0002925_abnormal_cardiovascular_devel0.27358619

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.26016820
2Exercise-induced myalgia (HP:0003738)6.73350375
3Calf muscle hypertrophy (HP:0008981)6.61862690
4Muscle hypertrophy of the lower extremities (HP:0008968)6.37888825
5Exercise-induced muscle cramps (HP:0003710)6.27831213
6Muscle fiber splitting (HP:0003555)6.03379759
7Ventricular tachycardia (HP:0004756)5.65790448
8Abnormality of the calf musculature (HP:0001430)5.33676282
9Hyporeflexia of lower limbs (HP:0002600)5.31096798
10Atrial fibrillation (HP:0005110)4.96320986
11Myoglobinuria (HP:0002913)4.93257438
12Primary atrial arrhythmia (HP:0001692)4.64826997
13Muscle fiber inclusion bodies (HP:0100299)4.60021263
14EMG: myopathic abnormalities (HP:0003458)4.56629139
15Subaortic stenosis (HP:0001682)4.53468421
16Abnormality of the left ventricular outflow tract (HP:0011103)4.53468421
17Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.48366297
18Supraventricular tachycardia (HP:0004755)4.46783115
19Difficulty running (HP:0009046)4.45122085
20Right ventricular cardiomyopathy (HP:0011663)4.41014721
21Supraventricular arrhythmia (HP:0005115)4.37272251
22Lipoatrophy (HP:0100578)4.34153181
23Increased connective tissue (HP:0009025)4.30211859
24Bundle branch block (HP:0011710)4.24290863
25Type 1 muscle fiber predominance (HP:0003803)4.13372940
26Syncope (HP:0001279)4.13222445
27Prolonged QT interval (HP:0001657)3.91873374
28Myotonia (HP:0002486)3.83875697
29Nemaline bodies (HP:0003798)3.78370455
30Dilated cardiomyopathy (HP:0001644)3.74540695
31Asymmetric septal hypertrophy (HP:0001670)3.71478855
32Rhabdomyolysis (HP:0003201)3.59516203
33Palpitations (HP:0001962)3.59045854
34Ventricular arrhythmia (HP:0004308)3.53769512
35Heart block (HP:0012722)3.41571683
36Difficulty climbing stairs (HP:0003551)3.32465305
37Ventricular fibrillation (HP:0001663)3.30953613
38Abnormal atrioventricular conduction (HP:0005150)3.21714963
39Atrioventricular block (HP:0001678)3.21377320
40Increased variability in muscle fiber diameter (HP:0003557)3.07937060
41Muscle stiffness (HP:0003552)2.98741443
42Abnormality of skeletal muscle fiber size (HP:0012084)2.97132343
43Distal arthrogryposis (HP:0005684)2.95997425
44Abnormal EKG (HP:0003115)2.88771124
45Neck muscle weakness (HP:0000467)2.78238365
46Fetal akinesia sequence (HP:0001989)2.77827197
47Myopathic facies (HP:0002058)2.63476704
48Ketoacidosis (HP:0001993)2.63379376
49Areflexia of lower limbs (HP:0002522)2.62522069
50Round ear (HP:0100830)2.61487672
51Malignant hyperthermia (HP:0002047)2.58643371
52Rimmed vacuoles (HP:0003805)2.57057420
53Bulbar palsy (HP:0001283)2.55755112
54Distal lower limb muscle weakness (HP:0009053)2.55310129
55Left ventricular hypertrophy (HP:0001712)2.53739859
56Calcaneovalgus deformity (HP:0001848)2.53359407
57Hypoplastic ischia (HP:0003175)2.50050681
58Limb-girdle muscle atrophy (HP:0003797)2.49101753
59Mildly elevated creatine phosphokinase (HP:0008180)2.39972499
60EMG: neuropathic changes (HP:0003445)2.39772608
61Absent phalangeal crease (HP:0006109)2.38237021
62Testicular atrophy (HP:0000029)2.30482470
63Distal lower limb amyotrophy (HP:0008944)2.29595364
64Muscular dystrophy (HP:0003560)2.23634111
65Gowers sign (HP:0003391)2.22427784
66Abnormality of the ischium (HP:0003174)2.22164091
67Steppage gait (HP:0003376)2.21353211
68Deformed tarsal bones (HP:0008119)2.20544436
69Hypoglycemic coma (HP:0001325)2.20334025
70Palmoplantar keratoderma (HP:0000982)2.14023415
71Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.12760518
72Ulnar deviation of the wrist (HP:0003049)2.12500842
73Dysmetric saccades (HP:0000641)2.11851567
74Spinal rigidity (HP:0003306)2.10830263
75Proximal amyotrophy (HP:0007126)2.10471741
76Abnormality of the shoulder girdle musculature (HP:0001435)2.08755226
77Frequent falls (HP:0002359)2.08675952
78Facial diplegia (HP:0001349)2.05929674
79Abnormality of the foot musculature (HP:0001436)2.05154423
80Central scotoma (HP:0000603)2.04702082
81Lower limb amyotrophy (HP:0007210)2.03950513
82Scapular winging (HP:0003691)2.03431349
83Generalized muscle weakness (HP:0003324)2.03215479
84Foot dorsiflexor weakness (HP:0009027)2.01192017
85Hyperinsulinemic hypoglycemia (HP:0000825)1.99153141
86Abnormal finger flexion creases (HP:0006143)1.96384484
87Ketosis (HP:0001946)1.96325069
88Weak cry (HP:0001612)1.95321780
89Hepatic necrosis (HP:0002605)1.94640628
90Pheochromocytoma (HP:0002666)1.93627529
91Abnormal mitochondria in muscle tissue (HP:0008316)1.92703043
92Slender build (HP:0001533)1.91679718
93Centrally nucleated skeletal muscle fibers (HP:0003687)1.86442720
94Large for gestational age (HP:0001520)1.85405886
95Acute necrotizing encephalopathy (HP:0006965)1.82030669
96Sudden cardiac death (HP:0001645)1.79668664
97Progressive muscle weakness (HP:0003323)1.78162550
98Respiratory insufficiency due to muscle weakness (HP:0002747)1.78141547
99Limb-girdle muscle weakness (HP:0003325)1.77399020
100Hyperglycemia (HP:0003074)1.75246203
101Conjunctival hamartoma (HP:0100780)1.75227077
102Abnormality of fatty-acid metabolism (HP:0004359)1.74706250
103Congestive heart failure (HP:0001635)1.73733181
104Increased muscle lipid content (HP:0009058)1.72861131
105Hamartoma of the eye (HP:0010568)1.72740004
106Waddling gait (HP:0002515)1.72102206
107Hip contracture (HP:0003273)1.71422049
108Cholelithiasis (HP:0001081)1.70010995
109Abnormality of the neuromuscular junction (HP:0003398)1.69450805
110Fatigable weakness (HP:0003473)1.69450805
111Broad metatarsal (HP:0001783)1.68641691
112Hyperkalemia (HP:0002153)1.66619363
113Abnormality of dicarboxylic acid metabolism (HP:0010995)1.66519003
114Dicarboxylic aciduria (HP:0003215)1.66519003
115Ragged-red muscle fibers (HP:0003200)1.66345485
116Nonprogressive disorder (HP:0003680)1.62230729
117Difficulty walking (HP:0002355)1.60593455
118Limited hip movement (HP:0008800)1.54537308
119Lower limb muscle weakness (HP:0007340)1.41891389
120Diaphragmatic weakness (HP:0009113)1.41503224
121Focal motor seizures (HP:0011153)1.41492486
122Febrile seizures (HP:0002373)1.40270125
123Rapidly progressive (HP:0003678)1.40015984
124Postural instability (HP:0002172)1.39015051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.63651294
2OBSCN5.61218615
3PHKG14.59007841
4PHKG24.59007841
5LMTK23.24550674
6PDK32.99668062
7PDK42.99668062
8DMPK2.87866461
9PINK12.50604108
10TRIB32.42092433
11MUSK2.22410139
12MYLK2.22134349
13PKN22.01624467
14PIK3CA1.99046020
15BCKDK1.91515159
16NEK11.91165809
17PDK21.82990248
18FRK1.65170393
19MAP3K71.42789498
20INSRR1.38055472
21NME11.36904788
22TIE11.29420249
23PAK31.25714209
24EPHA31.24412972
25CAMK2D1.18267638
26MAPK121.15128606
27STK241.12668928
28PRKD11.11640687
29DDR21.10069556
30PIK3CG1.07355696
31RIPK11.02886107
32PRKAA10.98731249
33MARK10.98727999
34STK380.96583119
35ROCK10.94380200
36GRK70.93260915
37WNK40.91230791
38PKN10.88818381
39MAP2K30.88574552
40CASK0.87670051
41PRKD30.87575920
42CDC42BPA0.87062737
43MOS0.86398708
44PRKAA20.84625685
45MAP2K40.84556888
46CAMK2B0.83602073
47CCNB10.81428979
48ILK0.77705165
49LIMK10.77302966
50MAP3K40.76132456
51ZAK0.75790469
52PAK60.74265017
53WNK10.71580904
54PDGFRA0.71314876
55MAP3K50.70907844
56TGFBR20.69942161
57CAMK2A0.69468820
58MAPK40.67471557
59EEF2K0.66738461
60CAMK40.66247260
61LATS20.65753742
62MAPK130.64655083
63SIK10.63918400
64STK38L0.59189546
65MAP3K130.55982894
66EPHA40.55559359
67IRAK30.55330921
68ICK0.55107314
69MAP3K30.54843709
70PRKCH0.54601900
71TAOK10.54248707
72CAMK10.53312835
73MAP3K60.52890662
74PDPK10.52216134
75AKT30.51876984
76EPHB10.51794685
77SGK30.51502779
78CAMK2G0.51483042
79ROCK20.50309455
80NTRK20.50109377
81MAPKAPK30.49722130
82PRKACB0.49253219
83PTK2B0.48602096
84NTRK30.48332709
85MAP2K10.47012203
86MAP2K60.46513331
87LATS10.46497051
88KSR20.45766450
89MAPK100.45304622
90SGK10.44569727
91UHMK10.44324701
92KSR10.44101256
93MARK30.43341433
94ERBB30.42832218
95DAPK20.42630945
96DAPK30.42580203
97PRKACA0.42052551
98PRKACG0.42023625
99RET0.41933241
100PDK10.41908372
101PRKCE0.41616082
102TRPM70.41076997
103TBK10.38129211
104AKT20.36227422
105PTK60.35888019
106BLK0.35437571
107RPS6KA30.35244268
108FGFR30.35037904
109JAK20.34521984
110MAPK110.34431284
111MARK20.33745347
112STK110.33451142
113CAMKK10.33274791
114STK390.33017734
115ACVR1B0.32865483
116TAOK20.32469271
117SGK20.32156627
118PRPF4B0.31754372
119CAMK1G0.30854041
120PRKG10.30634923
121MAP3K90.30537159
122MAP3K10.29961270
123FER0.29689329
124SGK2230.27317772
125SGK4940.27317772
126RPS6KC10.25208269
127RPS6KL10.25208269
128CDK50.22868366
129MTOR0.22684265
130NEK90.22173911
131MAPK70.22057463
132JAK10.19680236

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.73125627
2Cardiac muscle contraction_Homo sapiens_hsa042603.77809097
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.63195418
4Dilated cardiomyopathy_Homo sapiens_hsa054143.60879765
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.51393275
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39414713
7Propanoate metabolism_Homo sapiens_hsa006402.72658826
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.63529953
9Fatty acid degradation_Homo sapiens_hsa000712.35116025
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.02152444
11Parkinsons disease_Homo sapiens_hsa050122.00807788
12Carbon metabolism_Homo sapiens_hsa012001.95183503
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92672465
14Oxidative phosphorylation_Homo sapiens_hsa001901.85972565
15Fatty acid metabolism_Homo sapiens_hsa012121.82383720
16Alzheimers disease_Homo sapiens_hsa050101.66058992
17Butanoate metabolism_Homo sapiens_hsa006501.47990947
18Pyruvate metabolism_Homo sapiens_hsa006201.45389943
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35856059
20Glucagon signaling pathway_Homo sapiens_hsa049221.33334087
21Viral myocarditis_Homo sapiens_hsa054161.30766694
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27032958
23Starch and sucrose metabolism_Homo sapiens_hsa005001.25226869
24Insulin resistance_Homo sapiens_hsa049311.21393082
25cGMP-PKG signaling pathway_Homo sapiens_hsa040221.21092306
26Oxytocin signaling pathway_Homo sapiens_hsa049211.20102905
27Calcium signaling pathway_Homo sapiens_hsa040201.16558214
28Type II diabetes mellitus_Homo sapiens_hsa049301.14624301
29Insulin signaling pathway_Homo sapiens_hsa049101.14213866
30Insulin secretion_Homo sapiens_hsa049111.13384323
31Huntingtons disease_Homo sapiens_hsa050161.13258251
32Arginine biosynthesis_Homo sapiens_hsa002201.12359718
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09165445
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07222210
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.06318898
36PPAR signaling pathway_Homo sapiens_hsa033201.02527869
37Circadian entrainment_Homo sapiens_hsa047131.00903500
38Gastric acid secretion_Homo sapiens_hsa049710.96379216
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91667158
40Biosynthesis of amino acids_Homo sapiens_hsa012300.91369712
41Renin secretion_Homo sapiens_hsa049240.89551257
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.86481668
43AMPK signaling pathway_Homo sapiens_hsa041520.84042632
44Synaptic vesicle cycle_Homo sapiens_hsa047210.82459702
45Nicotine addiction_Homo sapiens_hsa050330.81850755
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81043916
47Fatty acid elongation_Homo sapiens_hsa000620.80953164
48Tryptophan metabolism_Homo sapiens_hsa003800.80132710
49Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79980124
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79934392
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75312425
52Lysine degradation_Homo sapiens_hsa003100.74677702
53Mineral absorption_Homo sapiens_hsa049780.73292925
54Circadian rhythm_Homo sapiens_hsa047100.71772242
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70724018
56Olfactory transduction_Homo sapiens_hsa047400.70190803
57cAMP signaling pathway_Homo sapiens_hsa040240.69601057
58ABC transporters_Homo sapiens_hsa020100.69401315
59Focal adhesion_Homo sapiens_hsa045100.69182700
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67108002
61beta-Alanine metabolism_Homo sapiens_hsa004100.66709778
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66595978
63Fatty acid biosynthesis_Homo sapiens_hsa000610.66397970
64Cholinergic synapse_Homo sapiens_hsa047250.66313587
65Tight junction_Homo sapiens_hsa045300.65944745
66Nitrogen metabolism_Homo sapiens_hsa009100.64704723
67Phenylalanine metabolism_Homo sapiens_hsa003600.64679960
68Long-term depression_Homo sapiens_hsa047300.64468309
69Prion diseases_Homo sapiens_hsa050200.64023580
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63024941
71GnRH signaling pathway_Homo sapiens_hsa049120.62665707
72GABAergic synapse_Homo sapiens_hsa047270.61090947
73Long-term potentiation_Homo sapiens_hsa047200.60708328
74Arginine and proline metabolism_Homo sapiens_hsa003300.59779676
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59659726
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59255643
77Lysosome_Homo sapiens_hsa041420.58763782
78Salivary secretion_Homo sapiens_hsa049700.58220796
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57472393
80Galactose metabolism_Homo sapiens_hsa000520.54647026
81Bile secretion_Homo sapiens_hsa049760.52754778
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51827224
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.51515332
84Glioma_Homo sapiens_hsa052140.51054726
85HIF-1 signaling pathway_Homo sapiens_hsa040660.50837915
86Other glycan degradation_Homo sapiens_hsa005110.50743394
87Morphine addiction_Homo sapiens_hsa050320.50613475
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.48890474
89Fructose and mannose metabolism_Homo sapiens_hsa000510.48236721
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48153674
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47772433
92Glutamatergic synapse_Homo sapiens_hsa047240.47225259
93FoxO signaling pathway_Homo sapiens_hsa040680.46728286
94Amphetamine addiction_Homo sapiens_hsa050310.46121460
95Taste transduction_Homo sapiens_hsa047420.44524497
96Dorso-ventral axis formation_Homo sapiens_hsa043200.44311174
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44179199
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44000311
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.43960425
100Pertussis_Homo sapiens_hsa051330.43468669
101Gap junction_Homo sapiens_hsa045400.43372809
102Dopaminergic synapse_Homo sapiens_hsa047280.42209235
103Cocaine addiction_Homo sapiens_hsa050300.41760058
104Osteoclast differentiation_Homo sapiens_hsa043800.41367353
105Pancreatic secretion_Homo sapiens_hsa049720.41318521
106Platelet activation_Homo sapiens_hsa046110.40400820
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38766654
108ErbB signaling pathway_Homo sapiens_hsa040120.38435467
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38113912
110Prolactin signaling pathway_Homo sapiens_hsa049170.37576835
111mTOR signaling pathway_Homo sapiens_hsa041500.36976624
112Peroxisome_Homo sapiens_hsa041460.36885855
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36721093
114TNF signaling pathway_Homo sapiens_hsa046680.36471375
115ECM-receptor interaction_Homo sapiens_hsa045120.35598527
116Estrogen signaling pathway_Homo sapiens_hsa049150.28751135
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28695405
118Amoebiasis_Homo sapiens_hsa051460.28512676
119Adherens junction_Homo sapiens_hsa045200.28419193
120Fat digestion and absorption_Homo sapiens_hsa049750.28365998
121Renal cell carcinoma_Homo sapiens_hsa052110.26776712
122VEGF signaling pathway_Homo sapiens_hsa043700.26007362
123Ovarian steroidogenesis_Homo sapiens_hsa049130.25063825
124MAPK signaling pathway_Homo sapiens_hsa040100.24369618
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22656125

Most similar genes based on co-expression Upload to Enrichr

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