ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fucose catabolic process (GO:0019317)	7.01239525
2	L-fucose metabolic process (GO:0042354)	7.01239525
3	L-fucose catabolic process (GO:0042355)	7.01239525
4	negative regulation of type 2 immune response (GO:0002829)	6.98900515
5	negative regulation of gluconeogenesis (GO:0045721)	6.84864025
6	relaxation of smooth muscle (GO:0044557)	6.71016208
7	relaxation of cardiac muscle (GO:0055119)	5.96497435
8	auditory receptor cell stereocilium organization (GO:0060088)	5.85460292
9	regulation of T-helper 1 cell differentiation (GO:0045625)	5.79669713
10	parturition (GO:0007567)	5.78044333
11	negative regulation of T-helper cell differentiation (GO:0045623)	5.48667231
12	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	5.48667231
13	post-embryonic morphogenesis (GO:0009886)	5.37683208
14	negative regulation of cAMP-mediated signaling (GO:0043951)	5.30286226
15	positive regulation of T-helper 1 type immune response (GO:0002827)	5.26345332
16	T cell migration (GO:0072678)	5.24651993
17	relaxation of muscle (GO:0090075)	5.08304384
18	cellular ketone body metabolic process (GO:0046950)	4.67560836
19	inner ear receptor stereocilium organization (GO:0060122)	4.64938915
20	regulation of skeletal muscle contraction (GO:0014819)	4.60740530
21	intestinal cholesterol absorption (GO:0030299)	4.44196474
22	regulation of T-helper 2 cell differentiation (GO:0045628)	4.33827948
23	negative regulation of cardiac muscle hypertrophy (GO:0010614)	4.32256781
24	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	4.30199409
25	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	4.25747970
26	branched-chain amino acid metabolic process (GO:0009081)	4.23073709
27	positive regulation of monocyte chemotaxis (GO:0090026)	4.20100323
28	xenobiotic catabolic process (GO:0042178)	4.18771090
29	ketone body metabolic process (GO:1902224)	4.10085844
30	regulation of type B pancreatic cell apoptotic process (GO:2000674)	4.08658282
31	branched-chain amino acid catabolic process (GO:0009083)	4.05172546
32	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.97175673
33	regulation of T-helper 1 type immune response (GO:0002825)	3.97038150
34	glycerophospholipid catabolic process (GO:0046475)	3.96264852
35	positive regulation of transcription regulatory region DNA binding (GO:2000679)	3.94316693
36	negative regulation of muscle hypertrophy (GO:0014741)	3.92223074
37	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.88254159
38	actin-myosin filament sliding (GO:0033275)	3.87865824
39	muscle filament sliding (GO:0030049)	3.87865824
40	potassium ion import (GO:0010107)	3.82141355
41	detection of light stimulus involved in sensory perception (GO:0050962)	3.79521937
42	detection of light stimulus involved in visual perception (GO:0050908)	3.79521937
43	regulation of T cell chemotaxis (GO:0010819)	3.76804698
44	positive regulation of T cell chemotaxis (GO:0010820)	3.76804698
45	negative regulation of alpha-beta T cell differentiation (GO:0046639)	3.61806157
46	sarcoplasmic reticulum calcium ion transport (GO:0070296)	3.56246482
47	negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)	3.54373656
48	negative regulation of muscle contraction (GO:0045932)	3.53321817
49	pigment granule transport (GO:0051904)	3.47255958
50	oxaloacetate metabolic process (GO:0006107)	3.45304687
51	negative regulation of smooth muscle contraction (GO:0045986)	3.44669170
52	fucose metabolic process (GO:0006004)	3.38341923
53	skeletal muscle contraction (GO:0003009)	3.36537631
54	amino-acid betaine transport (GO:0015838)	3.32417550
55	carnitine transport (GO:0015879)	3.32417550
56	positive regulation of protein homodimerization activity (GO:0090073)	3.28751680
57	positive regulation of T-helper cell differentiation (GO:0045624)	3.28525957
58	phenylpropanoid metabolic process (GO:0009698)	3.25138825
59	carnitine shuttle (GO:0006853)	3.21512331
60	negative regulation of alpha-beta T cell activation (GO:0046636)	3.21474588
61	actin-mediated cell contraction (GO:0070252)	3.19677732
62	establishment of pigment granule localization (GO:0051905)	3.19604709
63	vasodilation (GO:0042311)	3.15369977
64	negative regulation of receptor activity (GO:2000272)	3.11640323
65	positive regulation of vascular permeability (GO:0043117)	3.11231685
66	creatine metabolic process (GO:0006600)	3.10779727
67	negative regulation of calcium ion transmembrane transport (GO:1903170)	3.06077167
68	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	3.06077167
69	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.05598154
70	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.05150132
71	positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)	3.03004196
72	brain morphogenesis (GO:0048854)	3.02685673
73	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.00260505
74	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.00016331
75	regulation of cAMP-mediated signaling (GO:0043949)	2.94046433
76	cytidine metabolic process (GO:0046087)	2.92594272
77	cytidine catabolic process (GO:0006216)	2.92594272
78	cytidine deamination (GO:0009972)	2.92594272
79	actin filament-based movement (GO:0030048)	2.89532389
80	nitric oxide mediated signal transduction (GO:0007263)	2.88165366
81	fucosylation (GO:0036065)	2.84861040
82	regulation of gamma-delta T cell differentiation (GO:0045586)	2.82319444
83	succinate metabolic process (GO:0006105)	2.80322832
84	pigment granule localization (GO:0051875)	2.79244597
85	lysine catabolic process (GO:0006554)	2.77426553
86	lysine metabolic process (GO:0006553)	2.77426553
87	regulation of striated muscle contraction (GO:0006942)	2.77238471
88	lymphocyte chemotaxis (GO:0048247)	2.75389313
89	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.75243669
90	coenzyme catabolic process (GO:0009109)	2.75142016
91	positive regulation of gamma-delta T cell activation (GO:0046645)	2.74340350
92	regulation of type 2 immune response (GO:0002828)	2.73602870
93	regulation of relaxation of muscle (GO:1901077)	2.72640637
94	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	2.72105297
95	regulation of uterine smooth muscle contraction (GO:0070472)	2.69802887
96	positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)	2.68232756
97	mature B cell differentiation involved in immune response (GO:0002313)	2.67876364
98	fatty acid transmembrane transport (GO:1902001)	2.67447091
99	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.67412427
100	adenosine receptor signaling pathway (GO:0001973)	2.67142044

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT6_21828071_ChIP-Seq_BEAS2B_Human	6.50508326
2	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	6.19799959
3	EZH2_22144423_ChIP-Seq_EOC_Human	5.67593779
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.35078734
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.23563598
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.95447345
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.71421302
8	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.68744392
9	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.35636236
10	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.30393570
11	HTT_18923047_ChIP-ChIP_STHdh_Human	2.06414494
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.04822494
13	VDR_22108803_ChIP-Seq_LS180_Human	1.99466327
14	IGF1R_20145208_ChIP-Seq_DFB_Human	1.92486773
15	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.76700059
16	GATA1_22025678_ChIP-Seq_K562_Human	1.74091752
17	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.71030918
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.68020851
19	GBX2_23144817_ChIP-Seq_PC3_Human	1.53809500
20	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.52880923
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.50843929
22	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.44974769
23	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.43630264
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.41236832
25	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.39081741
26	STAT1_20625510_ChIP-Seq_HELA_Human	1.38897906
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.38863159
28	FUS_26573619_Chip-Seq_HEK293_Human	1.37322769
29	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.36412129
30	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.32547840
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31833579
32	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.31494939
33	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.29975576
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.28258268
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.27034736
36	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23859806
37	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.22951953
38	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.18841289
39	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.18339330
40	RUNX_20019798_ChIP-Seq_JUKART_Human	1.17565245
41	ZNF274_21170338_ChIP-Seq_K562_Hela	1.17475189
42	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.16137917
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.13535483
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.13535483
45	IRF1_19129219_ChIP-ChIP_H3396_Human	1.12401608
46	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.11222725
47	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.10892501
48	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.10342111
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.10255064
50	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.09159173
51	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.07904292
52	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07082693
53	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.06613321
54	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.05292864
55	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.04779961
56	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03945191
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.02107069
58	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.00802462
59	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.00067414
60	MYB_26560356_Chip-Seq_TH2_Human	0.98767589
61	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.98419714
62	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.98215244
63	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.97946080
64	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.97946080
65	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.97068650
66	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.96695475
67	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.95973240
68	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.95178137
69	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.93497111
70	EWS_26573619_Chip-Seq_HEK293_Human	0.92539226
71	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.85948549
72	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.85668849
73	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.84375660
74	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.84033133
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.83944158
76	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.83742733
77	AR_20517297_ChIP-Seq_VCAP_Human	0.83045498
78	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.82624102
79	TAF2_19829295_ChIP-Seq_ESCs_Human	0.82362095
80	PHF8_20622853_ChIP-Seq_HELA_Human	0.82100538
81	BCAT_22108803_ChIP-Seq_LS180_Human	0.81023687
82	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.80393952
83	STAT1_17558387_ChIP-Seq_HELA_Human	0.80364332
84	LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.80359393
85	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.80077973
86	NCOR_22424771_ChIP-Seq_293T_Human	0.80039305
87	DROSHA_22980978_ChIP-Seq_HELA_Human	0.79949922
88	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.79673793
89	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.79265861
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.79182124
91	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.79043696
92	GATA3_26560356_Chip-Seq_TH2_Human	0.77173497
93	CJUN_26792858_Chip-Seq_BT549_Human	0.75938248
94	P300_19829295_ChIP-Seq_ESCs_Human	0.75788915
95	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.75281922
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.75166239
97	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.75137622
98	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.73330430
99	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.72381403
100	TCF4_23295773_ChIP-Seq_U87_Human	0.71255022

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001661_extended_life_span	5.71060655
2	MP0005377_hearing/vestibular/ear_phenot	5.14602888
3	MP0003878_abnormal_ear_physiology	5.14602888
4	MP0004145_abnormal_muscle_electrophysio	3.51434832
5	MP0008775_abnormal_heart_ventricle	3.22557675
6	MP0003879_abnormal_hair_cell	3.16025277
7	MP0003646_muscle_fatigue	3.03172904
8	MP0003283_abnormal_digestive_organ	2.77321894
9	MP0000751_myopathy	2.66417148
10	MP0005220_abnormal_exocrine_pancreas	2.53808569
11	MP0005187_abnormal_penis_morphology	2.40750835
12	MP0004272_abnormal_basement_membrane	2.37454293
13	MP0000343_altered_response_to	2.33143511
14	MP0002272_abnormal_nervous_system	2.32018404
15	MP0003045_fibrosis	2.18566809
16	MP0001485_abnormal_pinna_reflex	2.07523033
17	MP0006276_abnormal_autonomic_nervous	2.03668254
18	MP0006072_abnormal_retinal_apoptosis	1.96625628
19	MP0010329_abnormal_lipoprotein_level	1.93309136
20	MP0004883_abnormal_blood_vessel	1.85870572
21	MP0001502_abnormal_circadian_rhythm	1.83555922
22	MP0000749_muscle_degeneration	1.81071768
23	MP0009780_abnormal_chondrocyte_physiolo	1.77990978
24	MP0002971_abnormal_brown_adipose	1.76045153
25	MP0002837_dystrophic_cardiac_calcinosis	1.71533980
26	MP0004215_abnormal_myocardial_fiber	1.69220694
27	MP0004924_abnormal_behavior	1.67507938
28	MP0005386_behavior/neurological_phenoty	1.67507938
29	MP0005332_abnormal_amino_acid	1.58807439
30	MP0005551_abnormal_eye_electrophysiolog	1.56451648
31	MP0002106_abnormal_muscle_physiology	1.55934883
32	MP0003959_abnormal_lean_body	1.49696110
33	MP0005084_abnormal_gallbladder_morpholo	1.49487472
34	MP0002928_abnormal_bile_duct	1.38251474
35	MP0005620_abnormal_muscle_contractility	1.31835670
36	MP0005595_abnormal_vascular_smooth	1.30883422
37	MP0006036_abnormal_mitochondrial_physio	1.28129504
38	MP0001984_abnormal_olfaction	1.27003659
39	MP0005671_abnormal_response_to	1.25726229
40	MP0001501_abnormal_sleep_pattern	1.21800597
41	MP0004036_abnormal_muscle_relaxation	1.20985549
42	MP0000230_abnormal_systemic_arterial	1.20946480
43	MP0002090_abnormal_vision	1.19454850
44	MP0005369_muscle_phenotype	1.19129830
45	MP0009785_altered_susceptibility_to	1.19120413
46	MP0005266_abnormal_metabolism	1.18297964
47	MP0005164_abnormal_response_to	1.13254345
48	MP0004087_abnormal_muscle_fiber	1.13062933
49	MP0003183_abnormal_peptide_metabolism	1.11870693
50	MP0001486_abnormal_startle_reflex	1.10781656
51	MP0002277_abnormal_respiratory_mucosa	1.08612090
52	MP0005166_decreased_susceptibility_to	1.08435856
53	MP0002972_abnormal_cardiac_muscle	1.07609194
54	MP0005058_abnormal_lysosome_morphology	0.98369756
55	MP0004084_abnormal_cardiac_muscle	0.98242012
56	MP0005584_abnormal_enzyme/coenzyme_acti	0.95737426
57	MP0001544_abnormal_cardiovascular_syste	0.94132314
58	MP0005385_cardiovascular_system_phenoty	0.94132314
59	MP0005535_abnormal_body_temperature	0.94049374
60	MP0001324_abnormal_eye_pigmentation	0.92677347
61	MP0003075_altered_response_to	0.91464373
62	MP0002405_respiratory_system_inflammati	0.88845691
63	MP0001756_abnormal_urination	0.86267374
64	MP0004742_abnormal_vestibular_system	0.85928714
65	MP0005330_cardiomyopathy	0.84787956
66	MP0004085_abnormal_heartbeat	0.84607717
67	MP0003567_abnormal_fetal_cardiomyocyte	0.83743294
68	MP0003638_abnormal_response/metabolism_	0.83719223
69	MP0005448_abnormal_energy_balance	0.83617523
70	MP0003690_abnormal_glial_cell	0.82674728
71	MP0001727_abnormal_embryo_implantation	0.82640582
72	MP0001944_abnormal_pancreas_morphology	0.81751369
73	MP0004147_increased_porphyrin_level	0.81689500
74	MP0003632_abnormal_nervous_system	0.80679304
75	MP0000747_muscle_weakness	0.79905090
76	MP0002876_abnormal_thyroid_physiology	0.77636763
77	MP0005670_abnormal_white_adipose	0.77373148
78	MP0002163_abnormal_gland_morphology	0.77182241
79	MP0003866_abnormal_defecation	0.75102998
80	MP0005379_endocrine/exocrine_gland_phen	0.75074846
81	MP0002269_muscular_atrophy	0.74505975
82	MP0003329_amyloid_beta_deposits	0.74205092
83	MP0002693_abnormal_pancreas_physiology	0.73941441
84	MP0008961_abnormal_basal_metabolism	0.73835650
85	MP0000750_abnormal_muscle_regeneration	0.73768196
86	MP0009643_abnormal_urine_homeostasis	0.73460428
87	MP0001664_abnormal_digestion	0.72934181
88	MP0002736_abnormal_nociception_after	0.72818273
89	MP0003300_gastrointestinal_ulcer	0.72779292
90	MP0005319_abnormal_enzyme/_coenzyme	0.72717111
91	MP0001881_abnormal_mammary_gland	0.70201873
92	MP0003252_abnormal_bile_duct	0.69113375
93	MP0002332_abnormal_exercise_endurance	0.67232786
94	MP0000639_abnormal_adrenal_gland	0.65515049
95	MP0003787_abnormal_imprinting	0.63616801
96	MP0000681_abnormal_thyroid_gland	0.62705100
97	MP0000604_amyloidosis	0.60888352
98	MP0010630_abnormal_cardiac_muscle	0.59273077
99	MP0001963_abnormal_hearing_physiology	0.59234267
100	MP0005165_increased_susceptibility_to	0.58944272

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Bilateral sensorineural hearing impairment (HP:0008619)	6.12349867
2	Polyphagia (HP:0002591)	5.83406700
3	Muscle fiber inclusion bodies (HP:0100299)	4.15876435
4	Nemaline bodies (HP:0003798)	4.07382192
5	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.97422481
6	Hypothermia (HP:0002045)	3.88722453
7	Asymmetric septal hypertrophy (HP:0001670)	3.83475082
8	Abnormality of the diencephalon (HP:0010662)	3.82108767
9	Exercise-induced myalgia (HP:0003738)	3.71954855
10	Gastrointestinal infarctions (HP:0005244)	3.50569720
11	Abnormal eating behavior (HP:0100738)	3.48076842
12	Type 1 muscle fiber predominance (HP:0003803)	3.44794499
13	Long clavicles (HP:0000890)	3.26575892
14	Areflexia of lower limbs (HP:0002522)	3.19175551
15	Hypergonadotropic hypogonadism (HP:0000815)	3.14430544
16	Distal arthrogryposis (HP:0005684)	3.09612152
17	Peritonitis (HP:0002586)	3.08766932
18	Ankyloglossia (HP:0010296)	3.05965683
19	Arthropathy (HP:0003040)	3.05491770
20	Aplastic anemia (HP:0001915)	3.02468817
21	Progressive muscle weakness (HP:0003323)	3.01459915
22	Abnormality of dental color (HP:0011073)	3.00634404
23	Muscle hypertrophy of the lower extremities (HP:0008968)	2.99769059
24	Delayed puberty (HP:0000823)	2.97805288
25	Truncus arteriosus (HP:0001660)	2.97480778
26	Exercise-induced muscle cramps (HP:0003710)	2.92280869
27	Short 1st metacarpal (HP:0010034)	2.89819464
28	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.89819464
29	Round ear (HP:0100830)	2.87584906
30	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.85419913
31	Abolished electroretinogram (ERG) (HP:0000550)	2.76883856
32	Calf muscle hypertrophy (HP:0008981)	2.75364627
33	Bundle branch block (HP:0011710)	2.73947396
34	Toxemia of pregnancy (HP:0100603)	2.72884517
35	Abnormality of oral frenula (HP:0000190)	2.67061708
36	EMG: myopathic abnormalities (HP:0003458)	2.64326603
37	Increased intramyocellular lipid droplets (HP:0012240)	2.64000601
38	Hyporeflexia of lower limbs (HP:0002600)	2.63712312
39	Abnormality of the calf musculature (HP:0001430)	2.63654337
40	Abnormality of skeletal muscle fiber size (HP:0012084)	2.62429456
41	Abnormality of the 1st metacarpal (HP:0010009)	2.52171304
42	Vertigo (HP:0002321)	2.50739182
43	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.49100231
44	Retinal atrophy (HP:0001105)	2.48835985
45	Increased muscle lipid content (HP:0009058)	2.47672778
46	Acute hepatic failure (HP:0006554)	2.47594550
47	Short hallux (HP:0010109)	2.45514018
48	Myoglobinuria (HP:0002913)	2.40753724
49	Increased variability in muscle fiber diameter (HP:0003557)	2.39255338
50	Adactyly (HP:0009776)	2.37796316
51	Increased CSF protein (HP:0002922)	2.35818786
52	Distal lower limb muscle weakness (HP:0009053)	2.35710475
53	Muscle fiber splitting (HP:0003555)	2.34235354
54	Hyponatremia (HP:0002902)	2.33679323
55	T lymphocytopenia (HP:0005403)	2.29674755
56	Abnormality of lateral ventricle (HP:0030047)	2.29446820
57	Sudden death (HP:0001699)	2.28201860
58	Renal cortical cysts (HP:0000803)	2.25527313
59	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.24896500
60	3-Methylglutaconic aciduria (HP:0003535)	2.23877725
61	Ulnar deviation of the wrist (HP:0003049)	2.23575070
62	Cardiomegaly (HP:0001640)	2.23176845
63	Fetal akinesia sequence (HP:0001989)	2.20115370
64	J-shaped sella turcica (HP:0002680)	2.16320459
65	Heart block (HP:0012722)	2.13807168
66	Ulnar deviation of finger (HP:0009465)	2.12943231
67	Medial flaring of the eyebrow (HP:0010747)	2.12821213
68	Palpitations (HP:0001962)	2.12703565
69	Abnormality of fatty-acid metabolism (HP:0004359)	2.09167648
70	Progressive neurologic deterioration (HP:0002344)	2.08716702
71	Hemiplegia (HP:0002301)	2.08271351
72	Limb hypertonia (HP:0002509)	2.08079283
73	Hypomagnesemia (HP:0002917)	2.06729891
74	Malignant hyperthermia (HP:0002047)	2.04077536
75	Hepatic necrosis (HP:0002605)	1.99172988
76	Ulnar deviation of the hand or of fingers of the hand (HP:0001193)	1.98636410
77	Increased hepatocellular lipid droplets (HP:0006565)	1.98367869
78	Left ventricular hypertrophy (HP:0001712)	1.97673845
79	Ketosis (HP:0001946)	1.96194200
80	Tetraplegia (HP:0002445)	1.95812844
81	Ventricular tachycardia (HP:0004756)	1.95756660
82	Growth hormone deficiency (HP:0000824)	1.94809029
83	Lipid accumulation in hepatocytes (HP:0006561)	1.93766458
84	Hyperinsulinemic hypoglycemia (HP:0000825)	1.93155834
85	Polyuria (HP:0000103)	1.89489147
86	Rhabdomyolysis (HP:0003201)	1.87866853
87	Atrioventricular block (HP:0001678)	1.85991996
88	Abnormality of renal resorption (HP:0011038)	1.84817589
89	Abnormality of sodium homeostasis (HP:0010931)	1.83883177
90	Abnormal atrioventricular conduction (HP:0005150)	1.83236547
91	Abnormality of T cell number (HP:0011839)	1.83224321
92	Renal Fanconi syndrome (HP:0001994)	1.82496696
93	Abnormality of magnesium homeostasis (HP:0004921)	1.80463230
94	Protruding tongue (HP:0010808)	1.79823468
95	Hydroureter (HP:0000072)	1.79718311
96	Exertional dyspnea (HP:0002875)	1.78371504
97	Congenital sensorineural hearing impairment (HP:0008527)	1.78332816
98	Short phalanx of the thumb (HP:0009660)	1.77962346
99	Hepatocellular necrosis (HP:0001404)	1.76025368
100	Abnormality of macrophages (HP:0004311)	1.74133541

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K10	3.77754975
2	OBSCN	3.72065458
3	BLK	3.63317507
4	MAP2K6	2.93130353
5	TTN	2.72509923
6	FRK	2.60751954
7	PHKG2	2.49469187
8	PHKG1	2.49469187
9	LMTK2	2.45780597
10	MAP3K4	2.33252024
11	TAF1	2.27189670
12	PASK	2.15514815
13	FLT3	1.87344056
14	SYK	1.78501941
15	ABL2	1.75639200
16	ITK	1.71758753
17	PINK1	1.71294670
18	MAP4K2	1.60329650
19	JAK2	1.58313304
20	TEC	1.49548635
21	MAPKAPK3	1.48229464
22	TXK	1.45325179
23	NUAK1	1.43730779
24	PIK3CA	1.43026049
25	VRK2	1.34669733
26	PRKG1	1.21560040
27	CSF1R	1.21010327
28	VRK1	1.19514083
29	NME2	1.15775355
30	PRKCQ	1.15757551
31	TESK2	1.13862249
32	BCKDK	1.13706928
33	IKBKB	1.10147086
34	TBK1	1.09622278
35	KIT	1.08702542
36	MAPK15	1.07652525
37	PKN2	1.04795420
38	PRKG2	1.04689465
39	PRKCE	1.04565565
40	MST4	1.03704575
41	EIF2AK3	1.02314855
42	JAK3	1.01858356
43	MAP4K1	1.01580338
44	KDR	0.96381329
45	MAP3K7	0.94386065
46	BTK	0.93620804
47	CAMK2D	0.92829509
48	GRK7	0.91852900
49	FES	0.90494580
50	LYN	0.89430820
51	TSSK6	0.89350432
52	MYLK	0.88956854
53	TRPM7	0.86286784
54	EIF2AK2	0.85841128
55	ZAP70	0.85820812
56	ADRBK2	0.83903311
57	MAPK12	0.83546692
58	GRK1	0.76878442
59	HIPK2	0.73620840
60	DAPK2	0.73138959
61	MAPK9	0.72050741
62	MARK1	0.71508060
63	ERBB3	0.68848276
64	TIE1	0.68125307
65	CCNB1	0.65548249
66	IGF1R	0.64433412
67	ADRBK1	0.62859516
68	MAPK7	0.61432632
69	EGFR	0.59825462
70	CSK	0.59775602
71	MUSK	0.57331015
72	TNK2	0.56570403
73	MARK2	0.56230524
74	MAP3K2	0.56044577
75	LCK	0.55929718
76	PIK3CG	0.54467180
77	INSR	0.53389190
78	TAOK1	0.52340631
79	RPS6KA1	0.51445631
80	CAMK4	0.50610535
81	IKBKE	0.50422431
82	MAPK3	0.50197474
83	AURKA	0.49890357
84	DAPK1	0.49017637
85	MAPK4	0.48020884
86	PRKACA	0.47356998
87	ABL1	0.47110837
88	RPS6KA6	0.45715891
89	PLK1	0.42866295
90	FYN	0.42549863
91	PRKCA	0.41739657
92	PRKACB	0.41726998
93	NTRK3	0.41474857
94	TYK2	0.38447990
95	PRKCH	0.38447849
96	MAPK13	0.37441190
97	CAMK2A	0.36744887
98	MAPK1	0.35741760
99	GSK3A	0.35668849
100	MAP2K3	0.35124063

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.78156306
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.62285384
3	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	3.22543091
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.85808024
5	Butanoate metabolism_Homo sapiens_hsa00650	2.35916786
6	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.30406462
7	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.24018274
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.11017679
9	Dilated cardiomyopathy_Homo sapiens_hsa05414	2.06613355
10	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	2.03215207
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.86984384
12	Propanoate metabolism_Homo sapiens_hsa00640	1.82440949
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.77903089
14	Gastric acid secretion_Homo sapiens_hsa04971	1.71742293
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.65933797
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.59484648
17	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.51668699
18	Fatty acid degradation_Homo sapiens_hsa00071	1.49728841
19	Primary immunodeficiency_Homo sapiens_hsa05340	1.47490519
20	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.44797925
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.43136256
22	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.37251600
23	Parkinsons disease_Homo sapiens_hsa05012	1.35907850
24	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.34417202
25	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.33537623
26	Phenylalanine metabolism_Homo sapiens_hsa00360	1.30551068
27	Renin secretion_Homo sapiens_hsa04924	1.27512916
28	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.24840154
29	Olfactory transduction_Homo sapiens_hsa04740	1.24233097
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.22882735
31	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.20296931
32	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.18651366
33	Collecting duct acid secretion_Homo sapiens_hsa04966	1.18469907
34	Platelet activation_Homo sapiens_hsa04611	1.13788835
35	Circadian entrainment_Homo sapiens_hsa04713	1.11844499
36	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.09500115
37	Insulin secretion_Homo sapiens_hsa04911	1.07909043
38	Peroxisome_Homo sapiens_hsa04146	1.06825450
39	Taste transduction_Homo sapiens_hsa04742	1.02708313
40	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.01319901
41	Salivary secretion_Homo sapiens_hsa04970	1.00193050
42	Leishmaniasis_Homo sapiens_hsa05140	0.99243331
43	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.96120444
44	Long-term depression_Homo sapiens_hsa04730	0.94740064
45	Shigellosis_Homo sapiens_hsa05131	0.94397134
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93173209
47	Phototransduction_Homo sapiens_hsa04744	0.91209168
48	Alzheimers disease_Homo sapiens_hsa05010	0.86894044
49	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.81782130
50	Regulation of autophagy_Homo sapiens_hsa04140	0.81658393
51	Glucagon signaling pathway_Homo sapiens_hsa04922	0.80936824
52	Nitrogen metabolism_Homo sapiens_hsa00910	0.79763000
53	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.79461164
54	Fatty acid elongation_Homo sapiens_hsa00062	0.76664181
55	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.76270955
56	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.75231036
57	Type I diabetes mellitus_Homo sapiens_hsa04940	0.71908859
58	Proteasome_Homo sapiens_hsa03050	0.71694586
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70031061
60	Arginine biosynthesis_Homo sapiens_hsa00220	0.69455044
61	Serotonergic synapse_Homo sapiens_hsa04726	0.68625554
62	Circadian rhythm_Homo sapiens_hsa04710	0.67832242
63	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.67676581
64	GnRH signaling pathway_Homo sapiens_hsa04912	0.67269798
65	Allograft rejection_Homo sapiens_hsa05330	0.66841895
66	Pancreatic secretion_Homo sapiens_hsa04972	0.63968250
67	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.63270568
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.63180335
69	RNA degradation_Homo sapiens_hsa03018	0.62789950
70	ABC transporters_Homo sapiens_hsa02010	0.62418681
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.60336181
72	Prolactin signaling pathway_Homo sapiens_hsa04917	0.58871915
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58003654
74	Huntingtons disease_Homo sapiens_hsa05016	0.57790777
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.56337460
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.55800815
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.52881021
78	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.52433745
79	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.51511978
80	Antigen processing and presentation_Homo sapiens_hsa04612	0.50654699
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.50260555
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.47640984
83	Graft-versus-host disease_Homo sapiens_hsa05332	0.46526068
84	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.46329599
85	Mineral absorption_Homo sapiens_hsa04978	0.44140131
86	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.44036992
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43868978
88	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.43223322
89	cAMP signaling pathway_Homo sapiens_hsa04024	0.42088746
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.41381470
91	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.41368844
92	Histidine metabolism_Homo sapiens_hsa00340	0.40696436
93	MAPK signaling pathway_Homo sapiens_hsa04010	0.38864668
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38317276
95	Rheumatoid arthritis_Homo sapiens_hsa05323	0.36821329
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36542190
97	GABAergic synapse_Homo sapiens_hsa04727	0.35773043
98	Chemokine signaling pathway_Homo sapiens_hsa04062	0.35645363
99	Osteoclast differentiation_Homo sapiens_hsa04380	0.35514287
100	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.34676006

PDE4DIPP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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