PDE5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1type B pancreatic cell development (GO:0003323)6.25743899
2COPI coating of Golgi vesicle (GO:0048205)5.42021337
3Golgi transport vesicle coating (GO:0048200)5.42021337
4glandular epithelial cell development (GO:0002068)5.34818735
5endocrine pancreas development (GO:0031018)5.22346956
6glandular epithelial cell differentiation (GO:0002067)4.91984543
7peptide hormone processing (GO:0016486)4.71154468
8mesodermal cell differentiation (GO:0048333)4.66310543
9regulation of integrin-mediated signaling pathway (GO:2001044)4.64642438
10sequestering of extracellular ligand from receptor (GO:0035581)4.62202041
11columnar/cuboidal epithelial cell development (GO:0002066)4.52817121
12positive regulation of Rho protein signal transduction (GO:0035025)4.35559911
13endocardial cushion development (GO:0003197)4.33811250
14thrombin receptor signaling pathway (GO:0070493)4.28179940
15pericardium development (GO:0060039)4.22949723
16cellular response to vitamin D (GO:0071305)4.13108623
17cellular response to hepatocyte growth factor stimulus (GO:0035729)4.10537184
18response to hepatocyte growth factor (GO:0035728)4.10537184
19exocrine pancreas development (GO:0031017)4.02344210
20extracellular matrix assembly (GO:0085029)3.97114744
21negative regulation of keratinocyte proliferation (GO:0010839)3.88460037
22fibroblast migration (GO:0010761)3.85852450
23chondrocyte proliferation (GO:0035988)3.77303587
24mesenchymal-epithelial cell signaling (GO:0060638)3.75626120
25kidney mesenchyme development (GO:0072074)3.69281079
26negative regulation of hormone biosynthetic process (GO:0032353)3.67345422
27negative regulation of hormone metabolic process (GO:0032351)3.67345422
28type B pancreatic cell proliferation (GO:0044342)3.65464567
29protein targeting to Golgi (GO:0000042)3.64067199
30COPII vesicle coating (GO:0048208)3.59537276
31positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.59111582
32ganglion development (GO:0061548)3.58164586
33detection of calcium ion (GO:0005513)3.55278699
34maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.55099040
35sequestering of metal ion (GO:0051238)3.54712830
36collagen fibril organization (GO:0030199)3.53676420
37embryonic camera-type eye morphogenesis (GO:0048596)3.49806515
38smooth muscle tissue development (GO:0048745)3.48677118
39retrograde transport, vesicle recycling within Golgi (GO:0000301)3.47767864
40insulin secretion (GO:0030073)3.47744212
41positive regulation of fibroblast migration (GO:0010763)3.45804486
42platelet aggregation (GO:0070527)3.45551260
43regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.45287080
44extracellular fibril organization (GO:0043206)3.41407795
45negative regulation of protein localization to cell surface (GO:2000009)3.38308393
46positive regulation of endothelial cell apoptotic process (GO:2000353)3.36455020
47inner ear receptor cell development (GO:0060119)3.35989227
48membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.35160673
49metanephric mesenchyme development (GO:0072075)3.34110137
50signal peptide processing (GO:0006465)3.31766170
51ER overload response (GO:0006983)3.30676614
52mesenchymal cell differentiation involved in renal system development (GO:2001012)3.28549830
53mesenchymal cell differentiation involved in kidney development (GO:0072161)3.28549830
54protein localization to cell surface (GO:0034394)3.28236902
55positive regulation of hormone biosynthetic process (GO:0046886)3.26401265
56regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.26090734
57bone trabecula formation (GO:0060346)3.23312223
58intestinal epithelial cell development (GO:0060576)3.22522104
59retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.22246698
60cell migration involved in heart development (GO:0060973)3.20760407
61intestinal absorption (GO:0050892)3.20033631
62relaxation of smooth muscle (GO:0044557)3.19504082
63dorsal/ventral axis specification (GO:0009950)3.19071990
64protein localization to Golgi apparatus (GO:0034067)3.18109871
65somite development (GO:0061053)3.17521833
66lung lobe morphogenesis (GO:0060463)3.16676546
67membrane repolarization during action potential (GO:0086011)3.15025745
68toxin metabolic process (GO:0009404)3.14335057
69negative regulation of fibroblast apoptotic process (GO:2000270)3.13500994
70positive regulation of receptor recycling (GO:0001921)3.13451853
71establishment of protein localization to Golgi (GO:0072600)3.13043807
72protein maturation by protein folding (GO:0022417)3.12083591
73substrate adhesion-dependent cell spreading (GO:0034446)3.10742345
74negative regulation of smooth muscle cell migration (GO:0014912)3.09178578
75lung vasculature development (GO:0060426)3.09001991
76embryonic foregut morphogenesis (GO:0048617)3.08903840
77endodermal cell differentiation (GO:0035987)3.07175460
78regulation of type B pancreatic cell apoptotic process (GO:2000674)3.04780171
79protein heterotrimerization (GO:0070208)3.04705264
80activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.00716699
81negative chemotaxis (GO:0050919)3.00189395
82regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.98092820
83anterior/posterior axis specification, embryo (GO:0008595)2.95932455
84positive regulation of insulin secretion (GO:0032024)2.93947414
85pancreas development (GO:0031016)2.93069613
86regulation of insulin secretion (GO:0050796)2.92999098
87tonic smooth muscle contraction (GO:0014820)2.92838690
88intra-Golgi vesicle-mediated transport (GO:0006891)2.89730172
89negative regulation of glycogen biosynthetic process (GO:0045719)2.89539822
90polarized epithelial cell differentiation (GO:0030859)2.88879251
91regulation of transforming growth factor beta2 production (GO:0032909)2.86698410
92respiratory tube development (GO:0030323)2.86435727
93hypotonic response (GO:0006971)2.86194741
94establishment of apical/basal cell polarity (GO:0035089)2.83078371
95regulation of glucocorticoid metabolic process (GO:0031943)2.81852155
96fibril organization (GO:0097435)2.81692331
97positive regulation of nuclease activity (GO:0032075)2.81339597
98positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.80899230
99induction of positive chemotaxis (GO:0050930)2.80842570
100muscle cell migration (GO:0014812)2.80408887
101sphingosine metabolic process (GO:0006670)2.78895685
102negative regulation of norepinephrine secretion (GO:0010700)2.77517406
103cellular response to vitamin (GO:0071295)2.77371100
104regulation of glucocorticoid secretion (GO:2000849)2.76684352
105SMAD protein complex assembly (GO:0007183)2.76394964
106peptide hormone secretion (GO:0030072)2.75365665
107regulation of glomerular filtration (GO:0003093)2.73765188
108platelet degranulation (GO:0002576)2.73356192
109negative regulation of homotypic cell-cell adhesion (GO:0034111)2.72906433
110extracellular regulation of signal transduction (GO:1900115)2.72544721
111extracellular negative regulation of signal transduction (GO:1900116)2.72544721
112negative regulation of axon extension involved in axon guidance (GO:0048843)2.71944188
113peptide secretion (GO:0002790)2.71873046
114regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.70069248
115dermatan sulfate biosynthetic process (GO:0030208)2.69951929
116mesenchymal cell differentiation (GO:0048762)2.69590644
117negative regulation of glycoprotein biosynthetic process (GO:0010561)2.69472554
118UDP-N-acetylglucosamine metabolic process (GO:0006047)2.69437538
119interleukin-1-mediated signaling pathway (GO:0070498)2.69055331
120diol metabolic process (GO:0034311)2.68771046
121prostate gland growth (GO:0060736)2.68248479
122surfactant homeostasis (GO:0043129)2.67797096
123protein retention in ER lumen (GO:0006621)2.66980766
124vesicle coating (GO:0006901)2.66868275
125cell differentiation involved in metanephros development (GO:0072202)2.66198849
126hippo signaling (GO:0035329)2.65308845
127regulation of non-canonical Wnt signaling pathway (GO:2000050)2.64905008
128histone H3-K36 demethylation (GO:0070544)2.64689660
129regulation of steroid hormone biosynthetic process (GO:0090030)2.64049870
130negative regulation of platelet activation (GO:0010544)2.63166948
131cell adhesion mediated by integrin (GO:0033627)2.62264637
132regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.61631940
133myelin assembly (GO:0032288)2.61219622
134negative regulation of stem cell proliferation (GO:2000647)2.61108448
135regulation of peptide hormone secretion (GO:0090276)2.59515637
136regulation of keratinocyte proliferation (GO:0010837)2.59197784
137regulation of nuclease activity (GO:0032069)2.59010231
138regulation of corticosteroid hormone secretion (GO:2000846)2.55982869
139negative regulation of osteoblast proliferation (GO:0033689)2.54954362
140coronary vasculature morphogenesis (GO:0060977)2.53386856
141regulation of peptide secretion (GO:0002791)2.53083334
142gland morphogenesis (GO:0022612)2.52389085
143lung alveolus development (GO:0048286)2.50435795
144regulation of lipoprotein metabolic process (GO:0050746)2.49007528
145vascular endothelial growth factor signaling pathway (GO:0038084)2.48740318
146regulation of platelet aggregation (GO:0090330)2.47336925
147positive regulation of bone mineralization (GO:0030501)2.46912734
148cell-substrate junction assembly (GO:0007044)2.46704620
149negative regulation of bone resorption (GO:0045779)2.46260982
150endoplasmic reticulum unfolded protein response (GO:0030968)2.46141182
151positive regulation of SMAD protein import into nucleus (GO:0060391)2.45366447
152negative regulation of catecholamine secretion (GO:0033604)2.45328562
153regulation of hormone biosynthetic process (GO:0046885)2.45162050
154regulation of focal adhesion assembly (GO:0051893)2.45065575
155regulation of cell-substrate junction assembly (GO:0090109)2.45065575
156hindbrain development (GO:0030902)2.44624176
157positive regulation of keratinocyte differentiation (GO:0045618)2.44592947
158peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.43642956
159cellular response to unfolded protein (GO:0034620)2.43520157
160embryonic eye morphogenesis (GO:0048048)2.43303545
161cell-matrix adhesion (GO:0007160)2.42619925
162negative regulation of insulin secretion (GO:0046676)2.42491188
163regulation of osteoblast proliferation (GO:0033688)2.42296356
164insulin-like growth factor receptor signaling pathway (GO:0048009)2.42030935
165regulation of endothelial cell apoptotic process (GO:2000351)2.41863122
166midgut development (GO:0007494)2.41802448
167regulation of vitamin metabolic process (GO:0030656)2.41373658
168columnar/cuboidal epithelial cell differentiation (GO:0002065)2.40757466
169negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.40570712
170establishment or maintenance of monopolar cell polarity (GO:0061339)2.40493738
171establishment of monopolar cell polarity (GO:0061162)2.40493738
172regulation of cardioblast proliferation (GO:0003264)2.40053905
173regulation of secondary heart field cardioblast proliferation (GO:0003266)2.40053905
174intestinal cholesterol absorption (GO:0030299)2.39995594
175regulation of smooth muscle cell migration (GO:0014910)2.39535043
176platelet-derived growth factor receptor signaling pathway (GO:0048008)2.39372195
177regulation of male gonad development (GO:2000018)2.39212894
178establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.38286376
179positive regulation of catenin import into nucleus (GO:0035413)2.38256150
180dermatan sulfate metabolic process (GO:0030205)2.38167035
181lipid translocation (GO:0034204)2.37886845
182phospholipid translocation (GO:0045332)2.37886845
183peptide transport (GO:0015833)2.36994848
184negative regulation of focal adhesion assembly (GO:0051895)2.35022663
185negative regulation of cell junction assembly (GO:1901889)2.35022663
186negative regulation of adherens junction organization (GO:1903392)2.35022663
187positive regulation of focal adhesion assembly (GO:0051894)2.34409252
188positive regulation of cell junction assembly (GO:1901890)2.34409252
189regulation of adherens junction organization (GO:1903391)2.34221828
190cGMP-mediated signaling (GO:0019934)2.32786687
191phagocytosis, engulfment (GO:0006911)2.32054474
192negative regulation of protein localization to plasma membrane (GO:1903077)2.31205777
193adrenal gland development (GO:0030325)2.30295873
194blood vessel maturation (GO:0001955)2.29591113
195positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.29533075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.48313141
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.31695282
3GATA1_22025678_ChIP-Seq_K562_Human3.07167994
4GBX2_23144817_ChIP-Seq_PC3_Human2.61707165
5NRF2_20460467_ChIP-Seq_MEFs_Mouse2.28069965
6NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.28069965
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.24387731
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.18627760
9PIAS1_25552417_ChIP-Seq_VCAP_Human2.16181237
10ZNF217_24962896_ChIP-Seq_MCF-7_Human2.13803404
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.07933691
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.06269470
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.06085457
14* BRD4_25478319_ChIP-Seq_HGPS_Human1.96570208
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.94918965
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92230007
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91620298
18EZH2_22144423_ChIP-Seq_EOC_Human1.87285609
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.83597802
20IGF1R_20145208_ChIP-Seq_DFB_Human1.80809339
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.74869200
22* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73615924
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73193399
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.72284737
25* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.69253354
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61394589
27* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60282441
28FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59988605
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59294366
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.58761091
31SMAD4_21799915_ChIP-Seq_A2780_Human1.53174663
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.52977925
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52124814
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51915705
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51155759
36STAT3_23295773_ChIP-Seq_U87_Human1.50679935
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49158087
38BCAT_22108803_ChIP-Seq_LS180_Human1.47714906
39TAF15_26573619_Chip-Seq_HEK293_Human1.45235238
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43362909
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41181020
42* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39826036
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37450846
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.35401086
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.35180551
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34940185
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34772140
48ISL1_27105846_Chip-Seq_CPCs_Mouse1.34748584
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34260265
50* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33949653
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33698799
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32479638
53* NANOG_18555785_Chip-Seq_ESCs_Mouse1.31274142
54EWS_26573619_Chip-Seq_HEK293_Human1.30887461
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30797588
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.30343813
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.29605813
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29331416
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29331416
60* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29176002
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28457545
62AHR_22903824_ChIP-Seq_MCF-7_Human1.26977027
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26786281
64* RNF2_27304074_Chip-Seq_ESCs_Mouse1.26571079
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.26281694
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25863901
67YAP1_20516196_ChIP-Seq_MESCs_Mouse1.24211497
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23931866
69ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21883242
70* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21853432
71* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21755642
72* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21273390
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.20905895
74* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20759653
75TP53_18474530_ChIP-ChIP_U2OS_Human1.20360315
76* TCF4_23295773_ChIP-Seq_U87_Human1.20096620
77* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19398722
78ZNF274_21170338_ChIP-Seq_K562_Hela1.19296241
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18998342
80P300_19829295_ChIP-Seq_ESCs_Human1.18796848
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.18716030
82* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18645658
83JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18085444
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.17575352
85TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17302363
86TBX3_20139965_ChIP-Seq_MESCs_Mouse1.17112280
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16757358
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.16533716
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16208004
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15906230
91RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15751141
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15366053
93DROSHA_22980978_ChIP-Seq_HELA_Human1.15075504
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14934398
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14727732
96PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13938418
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.13627716
98RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12747516
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.12339882
100RUNX2_22187159_ChIP-Seq_PCA_Human1.11078428
101CDX2_22108803_ChIP-Seq_LS180_Human1.10305551
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.10296318
103PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09692228
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.09564651
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.09383614
106CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08486698
107FUS_26573619_Chip-Seq_HEK293_Human1.08186093
108* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07944898
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.07771041
110CJUN_26792858_Chip-Seq_BT549_Human1.07606672
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.07472881
112WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07265003
113SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07153809
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07071819
115TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06628189
116SOX2_20726797_ChIP-Seq_SW620_Human1.06604157
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06028427
118TP53_16413492_ChIP-PET_HCT116_Human1.05583749
119* KDM2B_26808549_Chip-Seq_REH_Human1.05341614
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04737973
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.04300943
122AR_25329375_ChIP-Seq_VCAP_Human1.03866710
123AR_19668381_ChIP-Seq_PC3_Human1.03595030
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03093582
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03047052
126TP63_23658742_ChIP-Seq_EP156T_Human1.02803098
127CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02738351
128* P53_22387025_ChIP-Seq_ESCs_Mouse1.02512270
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02283348
130ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02185525
131FLI1_21867929_ChIP-Seq_TH2_Mouse1.02109938
132OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00436107
133SMAD3_21741376_ChIP-Seq_HESCs_Human1.00222276
134POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99705695
135TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99366919
136SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99136798
137* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97912780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder4.56141008
2MP0003283_abnormal_digestive_organ4.34343171
3MP0005275_abnormal_skin_tensile4.19906595
4MP0002877_abnormal_melanocyte_morpholog4.10793345
5MP0000678_abnormal_parathyroid_gland3.85901750
6MP0003566_abnormal_cell_adhesion3.28227985
7MP0003279_aneurysm3.25025563
8MP0009780_abnormal_chondrocyte_physiolo3.12214509
9MP0002693_abnormal_pancreas_physiology3.05872971
10MP0008004_abnormal_stomach_pH3.02615873
11MP0001944_abnormal_pancreas_morphology2.93689209
12MP0003705_abnormal_hypodermis_morpholog2.88670579
13MP0000462_abnormal_digestive_system2.86950878
14MP0005464_abnormal_platelet_physiology2.80562296
15MP0010352_gastrointestinal_tract_polyps2.60415443
16MP0000013_abnormal_adipose_tissue2.54401778
17MP0004043_abnormal_pH_regulation2.48314862
18MP0002909_abnormal_adrenal_gland2.40687208
19MP0005379_endocrine/exocrine_gland_phen2.37871879
20MP0000516_abnormal_urinary_system2.36516081
21MP0005367_renal/urinary_system_phenotyp2.36516081
22MP0003950_abnormal_plasma_membrane2.32114756
23MP0006054_spinal_hemorrhage2.28058684
24MP0009384_cardiac_valve_regurgitation2.14538854
25MP0004084_abnormal_cardiac_muscle2.12914980
26MP0003091_abnormal_cell_migration2.00017997
27MP0004036_abnormal_muscle_relaxation1.93987901
28MP0004264_abnormal_extraembryonic_tissu1.92676706
29MP0000566_synostosis1.90534395
30MP0002896_abnormal_bone_mineralization1.87540041
31MP0001879_abnormal_lymphatic_vessel1.84073112
32MP0001188_hyperpigmentation1.79609315
33MP0005623_abnormal_meninges_morphology1.78422481
34MP0002295_abnormal_pulmonary_circulatio1.77909443
35MP0005220_abnormal_exocrine_pancreas1.76485293
36MP0003300_gastrointestinal_ulcer1.73207628
37MP0000767_abnormal_smooth_muscle1.72853149
38MP0001270_distended_abdomen1.70003975
39MP0000537_abnormal_urethra_morphology1.69808492
40MP0005023_abnormal_wound_healing1.67050271
41MP0005595_abnormal_vascular_smooth1.65145860
42MP0001542_abnormal_bone_strength1.61512479
43MP0005257_abnormal_intraocular_pressure1.61254217
44MP0006072_abnormal_retinal_apoptosis1.60718971
45MP0002234_abnormal_pharynx_morphology1.60577281
46MP0003787_abnormal_imprinting1.58287433
47MP0003122_maternal_imprinting1.57794554
48MP0000613_abnormal_salivary_gland1.53489766
49MP0003119_abnormal_digestive_system1.51859942
50MP0003941_abnormal_skin_development1.50389109
51MP0003183_abnormal_peptide_metabolism1.48468817
52MP0005171_absent_coat_pigmentation1.48408383
53MP0000538_abnormal_urinary_bladder1.47945511
54MP0004272_abnormal_basement_membrane1.45491978
55MP0005620_abnormal_muscle_contractility1.39480663
56MP0004134_abnormal_chest_morphology1.38930051
57MP0005248_abnormal_Harderian_gland1.38398962
58MP0003045_fibrosis1.34659173
59MP0003868_abnormal_feces_composition1.31817487
60MP0002108_abnormal_muscle_morphology1.28959266
61MP0002638_abnormal_pupillary_reflex1.27564017
62MP0002837_dystrophic_cardiac_calcinosis1.26894987
63MP0002128_abnormal_blood_circulation1.26705224
64MP0001664_abnormal_digestion1.26698331
65MP0000631_abnormal_neuroendocrine_gland1.24113643
66MP0002254_reproductive_system_inflammat1.23997342
67MP0000003_abnormal_adipose_tissue1.23001747
68MP0004782_abnormal_surfactant_physiolog1.21587281
69MP0001986_abnormal_taste_sensitivity1.21254666
70MP0010368_abnormal_lymphatic_system1.21215101
71MP0001765_abnormal_ion_homeostasis1.20247917
72MP0002138_abnormal_hepatobiliary_system1.19971696
73MP0003195_calcinosis1.19311816
74MP0002277_abnormal_respiratory_mucosa1.19153532
75MP0009250_abnormal_appendicular_skeleto1.18120888
76MP0005187_abnormal_penis_morphology1.17505044
77MP0003866_abnormal_defecation1.16630635
78MP0000534_abnormal_ureter_morphology1.15236976
79MP0002009_preneoplasia1.14549513
80MP0008775_abnormal_heart_ventricle1.14197404
81MP0002078_abnormal_glucose_homeostasis1.14193057
82MP0003935_abnormal_craniofacial_develop1.11947878
83MP0002928_abnormal_bile_duct1.11633265
84MP0004510_myositis1.10403354
85MP0003890_abnormal_embryonic-extraembry1.08249573
86MP0005164_abnormal_response_to1.07857617
87MP0004145_abnormal_muscle_electrophysio1.07504077
88MP0001299_abnormal_eye_distance/1.06891700
89MP0000470_abnormal_stomach_morphology1.06621777
90MP0002177_abnormal_outer_ear1.04863052
91MP0003937_abnormal_limbs/digits/tail_de1.04335079
92MP0005503_abnormal_tendon_morphology1.03697298
93MP0002938_white_spotting1.03530482
94MP0003121_genomic_imprinting1.03056866
95MP0005646_abnormal_pituitary_gland1.02876143
96MP0003385_abnormal_body_wall1.02517099
97MP0003115_abnormal_respiratory_system1.01676900
98MP0001958_emphysema1.01214879
99MP0004215_abnormal_myocardial_fiber0.99483372
100MP0000751_myopathy0.98312695
101MP0000428_abnormal_craniofacial_morphol0.98086921
102MP0002060_abnormal_skin_morphology0.95397971
103MP0006138_congestive_heart_failure0.92607449
104MP0004883_abnormal_blood_vessel0.92483691
105MP0008438_abnormal_cutaneous_collagen0.91032077
106MP0004085_abnormal_heartbeat0.89603521
107MP0000163_abnormal_cartilage_morphology0.89574283
108MP0005508_abnormal_skeleton_morphology0.89263880
109MP0006292_abnormal_olfactory_placode0.89019353
110MP0005645_abnormal_hypothalamus_physiol0.88204684
111MP0003828_pulmonary_edema0.87718925
112MP0001243_abnormal_dermal_layer0.87611856
113MP0001661_extended_life_span0.85977155
114MP0001849_ear_inflammation0.85230942
115MP0002876_abnormal_thyroid_physiology0.84920926
116MP0003942_abnormal_urinary_system0.83814086
117MP0000230_abnormal_systemic_arterial0.82025592
118MP0001614_abnormal_blood_vessel0.82016099
119MP0003953_abnormal_hormone_level0.79419909
120MP0000569_abnormal_digit_pigmentation0.79416745
121MP0004484_altered_response_of0.79233814
122MP0002116_abnormal_craniofacial_bone0.79019594
123MP0002168_other_aberrant_phenotype0.78804771
124MP0002115_abnormal_skeleton_extremities0.75513390
125MP0003252_abnormal_bile_duct0.74787972
126MP0009053_abnormal_anal_canal0.73928835
127MP0009697_abnormal_copulation0.73312146
128MP0005408_hypopigmentation0.72979731
129MP0005390_skeleton_phenotype0.72504327
130MP0002972_abnormal_cardiac_muscle0.71801648
131MP0003879_abnormal_hair_cell0.71571784
132MP0001346_abnormal_lacrimal_gland0.71451359
133MP0005388_respiratory_system_phenotype0.71437347
134MP0002133_abnormal_respiratory_system0.71437347
135MP0008995_early_reproductive_senescence0.70799476
136MP0005167_abnormal_blood-brain_barrier0.70567648
137MP0000049_abnormal_middle_ear0.70205458
138MP0000249_abnormal_blood_vessel0.69188116
139MP0002925_abnormal_cardiovascular_devel0.68860430
140MP0000681_abnormal_thyroid_gland0.68679226
141MP0002109_abnormal_limb_morphology0.67940678
142MP0001175_abnormal_lung_morphology0.67552677
143MP0003755_abnormal_palate_morphology0.67334062
144MP0001756_abnormal_urination0.67292982
145MP0002233_abnormal_nose_morphology0.67021630
146MP0000432_abnormal_head_morphology0.66287451
147MP0005085_abnormal_gallbladder_physiolo0.65981290
148MP0002102_abnormal_ear_morphology0.65902929
149MP0005197_abnormal_uvea_morphology0.65751062
150MP0000733_abnormal_muscle_development0.65336552
151MP0001502_abnormal_circadian_rhythm0.64069277
152MP0005381_digestive/alimentary_phenotyp0.63396937
153MP0002127_abnormal_cardiovascular_syste0.63337488
154MP0003448_altered_tumor_morphology0.62736154
155MP0005165_increased_susceptibility_to0.62306059
156MP0000427_abnormal_hair_cycle0.59976571
157MP0000465_gastrointestinal_hemorrhage0.59801541
158MP0001851_eye_inflammation0.59325526
159MP0004130_abnormal_muscle_cell0.58176781

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.17954393
2Symptomatic seizures (HP:0011145)5.42385708
3Premature rupture of membranes (HP:0001788)5.36327307
4Increased mean platelet volume (HP:0011877)5.34759671
5Protrusio acetabuli (HP:0003179)4.95209729
6Hyperinsulinemic hypoglycemia (HP:0000825)4.83678113
7Decreased circulating renin level (HP:0003351)4.74169665
8Abnormal platelet volume (HP:0011876)4.70235517
9Vascular tortuosity (HP:0004948)4.57478776
10Type 1 muscle fiber predominance (HP:0003803)4.43146974
11Abnormality of calcium-phosphate metabolism (HP:0100530)4.36936050
12Menorrhagia (HP:0000132)4.33982113
13Follicular hyperkeratosis (HP:0007502)4.32511247
14Hypoglycemic seizures (HP:0002173)4.32010332
15Arterial tortuosity (HP:0005116)4.24583127
16Insulin-resistant diabetes mellitus (HP:0000831)4.00863115
17Intestinal atresia (HP:0011100)3.80947798
18Ankle contracture (HP:0006466)3.78874331
19Soft skin (HP:0000977)3.78347182
20Prolonged bleeding time (HP:0003010)3.61644717
21Hyperglycemia (HP:0003074)3.59627673
22Hypokalemia (HP:0002900)3.50360274
23Abnormality of renin-angiotensin system (HP:0000847)3.37729013
24Pancreatic islet-cell hyperplasia (HP:0004510)3.30611504
25Thin bony cortex (HP:0002753)3.17558980
26Osteomalacia (HP:0002749)3.11396956
27Hypoplastic labia majora (HP:0000059)3.11019511
28Hyperactive renin-angiotensin system (HP:0000841)3.08501224
29Midline defect of the nose (HP:0004122)3.07846854
30Slender build (HP:0001533)3.03127190
31Generalized aminoaciduria (HP:0002909)3.01036610
32Abnormality of the right ventricle (HP:0001707)3.00666713
33Abnormal pancreas size (HP:0012094)3.00311482
34Bladder diverticulum (HP:0000015)2.96311328
35Overgrowth (HP:0001548)2.95350877
36Hyperparathyroidism (HP:0000843)2.95291623
37Large for gestational age (HP:0001520)2.95169728
38Spinal rigidity (HP:0003306)2.94476049
39Spondylolisthesis (HP:0003302)2.93611639
40Abnormality of potassium homeostasis (HP:0011042)2.92021031
41Wormian bones (HP:0002645)2.89149987
42Abnormality of the labia majora (HP:0012881)2.87420237
43Petechiae (HP:0000967)2.86522510
44Abnormality of the pancreatic islet cells (HP:0006476)2.86345582
45Abnormality of endocrine pancreas physiology (HP:0012093)2.86345582
46Hypoglycemic coma (HP:0001325)2.83494797
47Abnormality of dentin (HP:0010299)2.82435403
48Gingival bleeding (HP:0000225)2.76394726
49Neonatal short-limb short stature (HP:0008921)2.74746266
50Dilatation of the ascending aorta (HP:0005111)2.65749586
51Aortic aneurysm (HP:0004942)2.63626929
52Unilateral renal agenesis (HP:0000122)2.63618956
53Increased variability in muscle fiber diameter (HP:0003557)2.63137661
54Conjugated hyperbilirubinemia (HP:0002908)2.61708222
55Cervical subluxation (HP:0003308)2.61197217
56Widely patent fontanelles and sutures (HP:0004492)2.60847660
57Hyperkalemia (HP:0002153)2.57444882
58Mesomelia (HP:0003027)2.54738676
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.54256736
60Osteolytic defects of the hand bones (HP:0009699)2.54256736
61Epistaxis (HP:0000421)2.53586169
62Congenital sensorineural hearing impairment (HP:0008527)2.52945893
63Hypoventilation (HP:0002791)2.52714215
64Long toe (HP:0010511)2.52382554
65Absent eyebrow (HP:0002223)2.51469892
66Mitral valve prolapse (HP:0001634)2.50961773
67Shawl scrotum (HP:0000049)2.49784937
68Wide anterior fontanel (HP:0000260)2.48431548
69Hydroureter (HP:0000072)2.43656810
70Hyperlipoproteinemia (HP:0010980)2.41746637
71Bowel diverticulosis (HP:0005222)2.33622317
72Volvulus (HP:0002580)2.32543644
73Shallow orbits (HP:0000586)2.27335805
74Abnormality of skeletal muscle fiber size (HP:0012084)2.24178939
75Joint laxity (HP:0001388)2.23430535
76Blue sclerae (HP:0000592)2.21713277
77Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.21441811
78Abnormal delivery (HP:0001787)2.19865336
79Abdominal distention (HP:0003270)2.19537843
80Papillary thyroid carcinoma (HP:0002895)2.19154561
81Abnormal biliary tract morphology (HP:0012440)2.18883845
82Hypothermia (HP:0002045)2.18027048
83Nemaline bodies (HP:0003798)2.15149355
84Anteriorly placed anus (HP:0001545)2.14819073
85Mildly elevated creatine phosphokinase (HP:0008180)2.12859004
86Aplasia/Hypoplasia of the fovea (HP:0008060)2.12641263
87Hypoplasia of the fovea (HP:0007750)2.12641263
88Peritonitis (HP:0002586)2.11272060
89Flat capital femoral epiphysis (HP:0003370)2.11063447
90Aortic dissection (HP:0002647)2.10972582
91Complete atrioventricular canal defect (HP:0001674)2.09752167
92Mitral stenosis (HP:0001718)2.08037366
93Short hallux (HP:0010109)2.07145454
94Cardiovascular calcification (HP:0011915)2.05737212
95Abnormality of chloride homeostasis (HP:0011422)2.05409816
96Purpura (HP:0000979)2.04466527
97Increased corneal curvature (HP:0100692)2.04241154
98Keratoconus (HP:0000563)2.04241154
99Papilledema (HP:0001085)2.02532089
100Muscle fiber inclusion bodies (HP:0100299)2.01877812
101Labial hypoplasia (HP:0000066)1.99923218
102Coronal craniosynostosis (HP:0004440)1.99319458
103Hyperextensible skin (HP:0000974)1.98966581
104Hyperphosphatemia (HP:0002905)1.98279962
105Aplasia/Hypoplasia of the hallux (HP:0008362)1.97033854
106Subacute progressive viral hepatitis (HP:0006572)1.95058637
107Limited hip movement (HP:0008800)1.94161405
108Enlarged epiphyses (HP:0010580)1.93273507
109Wide cranial sutures (HP:0010537)1.92303361
110Congenital glaucoma (HP:0001087)1.92237367
111Bruising susceptibility (HP:0000978)1.90926344
112Conjunctival telangiectasia (HP:0000524)1.90419561
113Abnormality of the fovea (HP:0000493)1.88736862
114Metabolic alkalosis (HP:0200114)1.88093094
115Atrioventricular canal defect (HP:0006695)1.87175308
116Lip pit (HP:0100267)1.86566506
117Spontaneous hematomas (HP:0007420)1.85787125
118Increased density of long bones (HP:0006392)1.83034997
119Tibial bowing (HP:0002982)1.82722802
120Camptodactyly of toe (HP:0001836)1.81936613
121Hypocalcemia (HP:0002901)1.81533817
122Striae distensae (HP:0001065)1.81294980
123Increased circulating renin level (HP:0000848)1.81074393
124Hypoalphalipoproteinemia (HP:0003233)1.80490513
125Genu recurvatum (HP:0002816)1.80147609
126Fragile skin (HP:0001030)1.79649533
127Mild short stature (HP:0003502)1.78841901
128Round ear (HP:0100830)1.76962779
129Facial diplegia (HP:0001349)1.76236717
130Chronic bronchitis (HP:0004469)1.76022288
131Atonic seizures (HP:0010819)1.74818329
132Neoplasm of the heart (HP:0100544)1.74582323
133Broad ribs (HP:0000885)1.74352241
134Cystic liver disease (HP:0006706)1.74329691
135Hypophosphatemia (HP:0002148)1.74225552
136Hypoplastic female external genitalia (HP:0012815)1.74134806
137Insulin resistance (HP:0000855)1.73805934
138Abnormality of the common coagulation pathway (HP:0010990)1.73574042
139Aneurysm (HP:0002617)1.73278506
140Hematochezia (HP:0002573)1.73153540
141Knee flexion contracture (HP:0006380)1.72549377
142Abnormality of the fingertips (HP:0001211)1.72060780
143Elbow flexion contracture (HP:0002987)1.70614943
144Persistence of primary teeth (HP:0006335)1.70550697
145Thoracolumbar scoliosis (HP:0002944)1.69597757
146Hip contracture (HP:0003273)1.69267881
147Abnormality of the fetal cardiovascular system (HP:0010948)1.69170583
148Abnormal umbilical cord blood vessels (HP:0011403)1.69170583
149Single umbilical artery (HP:0001195)1.69170583
150Hypoplasia of the iris (HP:0007676)1.69114669
151Abnormal platelet function (HP:0011869)1.68546149
152Impaired platelet aggregation (HP:0003540)1.68546149
153Abnormality of the metopic suture (HP:0005556)1.67909128
154Progressive sensorineural hearing impairment (HP:0000408)1.67809842
155Hyperaldosteronism (HP:0000859)1.66744199
156Broad metatarsal (HP:0001783)1.65865588
157Bradycardia (HP:0001662)1.64849754
158Gastrointestinal atresia (HP:0002589)1.63730125
159Pulmonary artery stenosis (HP:0004415)1.63379358
160Acanthocytosis (HP:0001927)1.62921357
161Tetany (HP:0001281)1.62424834
162Femoral bowing (HP:0002980)1.62380596
163Distal arthrogryposis (HP:0005684)1.61840678
164Cerebral aneurysm (HP:0004944)1.61317348
165Popliteal pterygium (HP:0009756)1.61124415
166Cutaneous finger syndactyly (HP:0010554)1.60898289
167Protruding ear (HP:0000411)1.60320523
168Abnormality of the nasal septum (HP:0000419)1.59436901
169Hypoplasia of dental enamel (HP:0006297)1.59366809
170Abnormality of polysaccharide metabolism (HP:0011012)1.59046300
171Abnormality of glycosaminoglycan metabolism (HP:0004371)1.59046300
172Abnormality of mucopolysaccharide metabolism (HP:0011020)1.59046300
173Progressive hearing impairment (HP:0001730)1.58593446
174Potter facies (HP:0002009)1.57510253
175Facial shape deformation (HP:0011334)1.57510253
176Agitation (HP:0000713)1.56530327
177Atrophic scars (HP:0001075)1.56384982
178Prominent metopic ridge (HP:0005487)1.55593661
179Villous atrophy (HP:0011473)1.55271516
180Abnormality of small intestinal villus morphology (HP:0011472)1.55271516
181Ketoacidosis (HP:0001993)1.51983520
182Micronodular cirrhosis (HP:0001413)1.50671194
183Metaphyseal irregularity (HP:0003025)1.50426075
184Chronic hepatic failure (HP:0100626)1.49245581
185Aortic regurgitation (HP:0001659)1.47783981
186Cranial hyperostosis (HP:0004437)1.45517543

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.59568044
2FRK4.37361764
3TAOK34.03820833
4PASK3.24622923
5IRAK32.79488394
6GRK72.54237464
7PRKD32.47748406
8LATS12.47358563
9NUAK12.40433733
10ACVR1B2.28607261
11AKT32.23685057
12EPHA32.23587357
13HIPK22.14093332
14GRK52.07258331
15PDGFRA2.01920539
16MAP3K22.00629520
17TIE11.90346335
18CDC42BPA1.88255711
19ADRBK11.79184141
20MAPK151.78535192
21ADRBK21.77713332
22MYLK1.76752120
23PTK61.64472848
24BRD41.59489494
25PTK2B1.53595745
26MST41.43255641
27TRPM71.39531095
28ZAK1.38074179
29DMPK1.29459673
30EPHB21.29009912
31CAMKK21.26226270
32BMX1.25740306
33IRAK11.19633865
34FLT31.18103901
35FER1.14311278
36PNCK1.14308890
37PLK21.13861195
38PRKCH1.11260153
39IRAK21.08734658
40MAP3K11.06417847
41ILK1.05872431
42PRKD21.05601933
43PTK21.05073229
44NLK0.98947568
45RIPK10.96479598
46STK240.93878869
47CASK0.92908291
48STK380.82974851
49TNIK0.82675646
50TEC0.81602588
51SGK20.81420057
52WNK10.81268673
53NTRK10.78700041
54PDGFRB0.78364314
55FGFR30.78213001
56NTRK30.77930464
57BRSK20.77837164
58PRKCE0.76347074
59DAPK30.75652529
60DDR20.75280485
61STK30.74078108
62IRAK40.71377622
63MAP3K120.71250870
64STK38L0.71136527
65MAP2K10.69862205
66OBSCN0.68098639
67CHUK0.66799393
68FGFR20.66521366
69JAK10.66406308
70ITK0.65923420
71UHMK10.64791084
72WNK40.64179152
73TTN0.63440172
74MARK20.61815193
75MKNK20.61133245
76SGK30.60390496
77GRK60.59712014
78STK40.59253021
79ROCK20.58328820
80PRKAA10.57533697
81LMTK20.57129795
82TGFBR20.55257656
83CDK30.54939993
84CDK120.54634838
85MAP2K20.54225900
86PRKG20.53986051
87BMPR1B0.52969441
88GSK3A0.52498792
89ERBB40.51749979
90MAPKAPK30.50698314
91PRKAA20.50084298
92LIMK10.49373056
93MELK0.49072156
94ERBB30.48815037
95STK390.48313720
96SCYL20.48221266
97MET0.47739615
98GRK10.47029541
99KIT0.45800901
100CAMK1G0.45024940
101PAK10.44467155
102PIK3CG0.44116525
103ERBB20.43193894
104MAPK130.43066987
105PRKD10.42503093
106PIK3CA0.42020353
107CDK90.41785759
108* PRKG10.41727758
109RET0.40707753
110PAK30.39558636
111TGFBR10.38989929
112NEK60.38869780
113CSNK1A1L0.38860377
114IGF1R0.37611524
115PRKDC0.37489470
116CAMK1D0.37404876
117PAK20.37213676
118RPS6KA20.36276024
119CAMK2D0.36259907
120SGK4940.35786099
121SGK2230.35786099
122WNK30.34959965
123TXK0.34662072
124MAP3K70.34616599
125ROCK10.34416823
126RPS6KB10.34124040
127AKT10.33924220
128MAPK140.33821366
129ATM0.33255427
130SRPK10.32685597
131YES10.32603883
132MAP3K50.32308565
133BCR0.32264083
134CSNK1A10.31102407
135MTOR0.31027016
136NEK90.30319686
137CDK80.29817388
138CAMK2G0.29218447
139PKN20.29001228
140EIF2AK10.28921716
141CSF1R0.28616247
142FGFR10.28347722
143ZAP700.27125385
144CAMK2A0.25360569
145PRKCB0.24546064
146INSR0.24225823
147ABL10.22962474

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.81836212
2Protein export_Homo sapiens_hsa030602.96513451
3Insulin secretion_Homo sapiens_hsa049112.89871755
4Type II diabetes mellitus_Homo sapiens_hsa049302.29825851
5Sulfur metabolism_Homo sapiens_hsa009202.29152339
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.08610262
7Regulation of actin cytoskeleton_Homo sapiens_hsa048102.05459703
8Carbohydrate digestion and absorption_Homo sapiens_hsa049731.88871684
9Circadian rhythm_Homo sapiens_hsa047101.74515699
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.59131126
11Taste transduction_Homo sapiens_hsa047421.56651521
12Melanoma_Homo sapiens_hsa052181.56082824
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.50635815
14Type I diabetes mellitus_Homo sapiens_hsa049401.41446309
15Protein digestion and absorption_Homo sapiens_hsa049741.38174916
16Nitrogen metabolism_Homo sapiens_hsa009101.35433150
17Vascular smooth muscle contraction_Homo sapiens_hsa042701.31552139
18Pancreatic secretion_Homo sapiens_hsa049721.30115472
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22599334
20Cocaine addiction_Homo sapiens_hsa050301.21139164
21Thyroid hormone synthesis_Homo sapiens_hsa049181.21012330
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19857439
23Sphingolipid metabolism_Homo sapiens_hsa006001.18941014
24Complement and coagulation cascades_Homo sapiens_hsa046101.17303376
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.14317113
26Adherens junction_Homo sapiens_hsa045201.10526259
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10487321
28Vibrio cholerae infection_Homo sapiens_hsa051101.10382084
29ECM-receptor interaction_Homo sapiens_hsa045121.10152003
30Calcium signaling pathway_Homo sapiens_hsa040201.09234454
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08995297
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08808100
33* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08100096
34N-Glycan biosynthesis_Homo sapiens_hsa005101.03752878
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03398753
36Amphetamine addiction_Homo sapiens_hsa050311.02220113
37Rap1 signaling pathway_Homo sapiens_hsa040151.01998833
38Renin secretion_Homo sapiens_hsa049241.00947720
39Mineral absorption_Homo sapiens_hsa049781.00414443
40Glioma_Homo sapiens_hsa052140.99343282
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98459449
42Phospholipase D signaling pathway_Homo sapiens_hsa040720.96515800
43Prostate cancer_Homo sapiens_hsa052150.95617666
44Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95602420
45Ovarian steroidogenesis_Homo sapiens_hsa049130.95269129
46Prolactin signaling pathway_Homo sapiens_hsa049170.95116199
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93306135
48Cholinergic synapse_Homo sapiens_hsa047250.92406319
49Hedgehog signaling pathway_Homo sapiens_hsa043400.90929774
50Focal adhesion_Homo sapiens_hsa045100.90725598
51Circadian entrainment_Homo sapiens_hsa047130.87006789
52Basal cell carcinoma_Homo sapiens_hsa052170.86612485
53Serotonergic synapse_Homo sapiens_hsa047260.86247612
54Insulin resistance_Homo sapiens_hsa049310.85056301
55Melanogenesis_Homo sapiens_hsa049160.84430984
56Estrogen signaling pathway_Homo sapiens_hsa049150.84041278
57Dilated cardiomyopathy_Homo sapiens_hsa054140.81497408
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80751650
59Long-term depression_Homo sapiens_hsa047300.79257510
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78792293
61ABC transporters_Homo sapiens_hsa020100.78075304
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77248011
63Dorso-ventral axis formation_Homo sapiens_hsa043200.76831627
64Wnt signaling pathway_Homo sapiens_hsa043100.76116385
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75900381
66Inositol phosphate metabolism_Homo sapiens_hsa005620.74296104
67Long-term potentiation_Homo sapiens_hsa047200.71143804
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70958894
69Endometrial cancer_Homo sapiens_hsa052130.70765584
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.68718995
71Glucagon signaling pathway_Homo sapiens_hsa049220.68502452
72cAMP signaling pathway_Homo sapiens_hsa040240.68356125
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68340744
74Selenocompound metabolism_Homo sapiens_hsa004500.68153391
75Dopaminergic synapse_Homo sapiens_hsa047280.67080885
76Arachidonic acid metabolism_Homo sapiens_hsa005900.66929077
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65777753
78Tight junction_Homo sapiens_hsa045300.65206553
79Morphine addiction_Homo sapiens_hsa050320.64153133
80Other glycan degradation_Homo sapiens_hsa005110.64061949
81Endocytosis_Homo sapiens_hsa041440.62456959
82Renin-angiotensin system_Homo sapiens_hsa046140.62297270
83Choline metabolism in cancer_Homo sapiens_hsa052310.61890978
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61727627
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61465533
86Gastric acid secretion_Homo sapiens_hsa049710.60919710
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58291427
88Glutathione metabolism_Homo sapiens_hsa004800.57631193
89GABAergic synapse_Homo sapiens_hsa047270.57616320
90Hippo signaling pathway_Homo sapiens_hsa043900.57085025
91Fat digestion and absorption_Homo sapiens_hsa049750.56967662
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56324780
93FoxO signaling pathway_Homo sapiens_hsa040680.54927547
94Lysine degradation_Homo sapiens_hsa003100.53917582
95Gap junction_Homo sapiens_hsa045400.52618513
96TGF-beta signaling pathway_Homo sapiens_hsa043500.51407962
97MicroRNAs in cancer_Homo sapiens_hsa052060.51207071
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51205219
99Salivary secretion_Homo sapiens_hsa049700.50448235
100GnRH signaling pathway_Homo sapiens_hsa049120.50405319
101Proteoglycans in cancer_Homo sapiens_hsa052050.50185676
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49717514
103Glutamatergic synapse_Homo sapiens_hsa047240.49595789
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49384397
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49221976
106Lysosome_Homo sapiens_hsa041420.48803878
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.48425784
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48164738
109Amoebiasis_Homo sapiens_hsa051460.48080431
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47517603
111Platelet activation_Homo sapiens_hsa046110.47266173
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.46989848
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46619775
114Chronic myeloid leukemia_Homo sapiens_hsa052200.46500592
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46075043
116Axon guidance_Homo sapiens_hsa043600.45780856
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44414567
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.44250873
119Malaria_Homo sapiens_hsa051440.43998793
120Alcoholism_Homo sapiens_hsa050340.43104959
121Glycerolipid metabolism_Homo sapiens_hsa005610.42859050
122Small cell lung cancer_Homo sapiens_hsa052220.41916033
123Pathways in cancer_Homo sapiens_hsa052000.41060444
124Pancreatic cancer_Homo sapiens_hsa052120.40839879
125Renal cell carcinoma_Homo sapiens_hsa052110.40655588
126MAPK signaling pathway_Homo sapiens_hsa040100.40064206
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39929772
128Thyroid cancer_Homo sapiens_hsa052160.39642385
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39320203
130mTOR signaling pathway_Homo sapiens_hsa041500.38895791
131Ras signaling pathway_Homo sapiens_hsa040140.38265715
132Oxytocin signaling pathway_Homo sapiens_hsa049210.37716511

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