PDE6A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* regulation of rhodopsin mediated signaling pathway (GO:0022400)7.83861905
2* rhodopsin mediated signaling pathway (GO:0016056)7.72487789
3retinal cone cell development (GO:0046549)6.72092166
4photoreceptor cell maintenance (GO:0045494)6.50944144
5short-term memory (GO:0007614)6.42576905
6axon ensheathment in central nervous system (GO:0032291)5.80237998
7central nervous system myelination (GO:0022010)5.80237998
8photoreceptor cell development (GO:0042461)5.51830545
9detection of light stimulus involved in visual perception (GO:0050908)5.50845509
10detection of light stimulus involved in sensory perception (GO:0050962)5.50845509
11eye photoreceptor cell development (GO:0042462)5.35788606
12photoreceptor cell differentiation (GO:0046530)5.18668619
13eye photoreceptor cell differentiation (GO:0001754)5.18668619
14retinal rod cell development (GO:0046548)4.96638979
15presynaptic membrane assembly (GO:0097105)4.88885386
16behavioral response to nicotine (GO:0035095)4.63166737
17retina layer formation (GO:0010842)4.60675545
18* phototransduction (GO:0007602)4.52858090
19* phototransduction, visible light (GO:0007603)4.46951082
20* detection of visible light (GO:0009584)4.44248510
21fucose catabolic process (GO:0019317)4.39262859
22L-fucose metabolic process (GO:0042354)4.39262859
23L-fucose catabolic process (GO:0042355)4.39262859
24presynaptic membrane organization (GO:0097090)4.37967550
25* detection of light stimulus (GO:0009583)4.37879887
26negative regulation of execution phase of apoptosis (GO:1900118)4.31357093
27* visual perception (GO:0007601)4.18754538
28* sensory perception of light stimulus (GO:0050953)4.15551432
29tryptophan catabolic process (GO:0006569)4.14297597
30indole-containing compound catabolic process (GO:0042436)4.14297597
31indolalkylamine catabolic process (GO:0046218)4.14297597
32detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.10153459
33negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.08199007
34positive regulation of protein kinase C signaling (GO:0090037)3.97460718
35protein-chromophore linkage (GO:0018298)3.97296543
36kynurenine metabolic process (GO:0070189)3.89722805
37indolalkylamine metabolic process (GO:0006586)3.88043693
38nonmotile primary cilium assembly (GO:0035058)3.85100128
39positive regulation of guanylate cyclase activity (GO:0031284)3.83795379
40protein localization to synapse (GO:0035418)3.82422980
41fatty acid elongation (GO:0030497)3.81571447
42postsynaptic membrane organization (GO:0001941)3.78683349
43cellular ketone body metabolic process (GO:0046950)3.78150133
44response to pheromone (GO:0019236)3.77819955
45neuron cell-cell adhesion (GO:0007158)3.74514471
46neuronal action potential propagation (GO:0019227)3.69337510
47DNA deamination (GO:0045006)3.67999031
48limb bud formation (GO:0060174)3.67295608
49positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.52788015
50tryptophan metabolic process (GO:0006568)3.49654638
51ketone body metabolic process (GO:1902224)3.43942302
52neural tube formation (GO:0001841)3.42030372
53regulation of guanylate cyclase activity (GO:0031282)3.40868259
54respiratory chain complex IV assembly (GO:0008535)3.39407113
55piRNA metabolic process (GO:0034587)3.38819180
56righting reflex (GO:0060013)3.37474495
57water-soluble vitamin biosynthetic process (GO:0042364)3.36174421
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.35477032
59* detection of external stimulus (GO:0009581)3.34035523
60behavioral response to ethanol (GO:0048149)3.30040659
61* detection of abiotic stimulus (GO:0009582)3.28343749
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25021594
63neuron remodeling (GO:0016322)3.19955127
64negative regulation of cytosolic calcium ion concentration (GO:0051481)3.18411553
65platelet dense granule organization (GO:0060155)3.15559364
66* retina development in camera-type eye (GO:0060041)3.14701241
67omega-hydroxylase P450 pathway (GO:0097267)3.12430742
68reflex (GO:0060004)3.10534590
69cell morphogenesis involved in neuron differentiation (GO:0048667)3.08794270
70protein complex biogenesis (GO:0070271)3.07716594
71long-chain fatty acid biosynthetic process (GO:0042759)3.02466722
72protein K11-linked deubiquitination (GO:0035871)3.01791516
73cytochrome complex assembly (GO:0017004)2.99956332
74gamma-aminobutyric acid transport (GO:0015812)2.98943436
75epithelial cilium movement (GO:0003351)2.98809729
76indole-containing compound metabolic process (GO:0042430)2.96472527
77protein heterotetramerization (GO:0051290)2.96469228
78import into cell (GO:0098657)2.96384604
79kidney morphogenesis (GO:0060993)2.95236274
80organ growth (GO:0035265)2.93324000
81sulfation (GO:0051923)2.92256442
82regulation of hippo signaling (GO:0035330)2.92140456
83L-amino acid import (GO:0043092)2.91789785
84cornea development in camera-type eye (GO:0061303)2.91410768
85cellular biogenic amine catabolic process (GO:0042402)2.91054666
86amine catabolic process (GO:0009310)2.91054666
87preassembly of GPI anchor in ER membrane (GO:0016254)2.90250344
88regulation of catecholamine metabolic process (GO:0042069)2.89844748
89regulation of dopamine metabolic process (GO:0042053)2.89844748
90negative regulation of telomere maintenance (GO:0032205)2.87238620
91regulation of nuclear cell cycle DNA replication (GO:0033262)2.86895803
92* cellular response to light stimulus (GO:0071482)2.85330703
93mitochondrial respiratory chain complex assembly (GO:0033108)2.84884900
94cilium morphogenesis (GO:0060271)2.83671272
95myelination (GO:0042552)2.83585809
96mitochondrial respiratory chain complex I assembly (GO:0032981)2.82583905
97NADH dehydrogenase complex assembly (GO:0010257)2.82583905
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82583905
99ensheathment of neurons (GO:0007272)2.81677989
100axon ensheathment (GO:0008366)2.81677989
101melanin metabolic process (GO:0006582)2.80135913
102cranial nerve morphogenesis (GO:0021602)2.80131792
103protein polyglutamylation (GO:0018095)2.80025820
104positive regulation of synapse assembly (GO:0051965)2.78582370
105neuronal action potential (GO:0019228)2.78239871
106regulation of cGMP metabolic process (GO:0030823)2.77852230
107reciprocal meiotic recombination (GO:0007131)2.75650014
108reciprocal DNA recombination (GO:0035825)2.75650014
109regulation of timing of cell differentiation (GO:0048505)2.75431408
110negative regulation of mast cell activation (GO:0033004)2.75429456
111auditory receptor cell stereocilium organization (GO:0060088)2.74728999
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74558868
113regulation of protein kinase A signaling (GO:0010738)2.73908438
114recombinational repair (GO:0000725)2.73752170
115melanin biosynthetic process (GO:0042438)2.72360953
116negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.71828924
117positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.70588111
118double-strand break repair via homologous recombination (GO:0000724)2.70425565
119L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.69191348
120neuron recognition (GO:0008038)2.69004562
121DNA methylation involved in gamete generation (GO:0043046)2.68290344
122negative regulation of neurotransmitter transport (GO:0051589)2.67627229
123regulation of pigment cell differentiation (GO:0050932)2.66717851
124positive regulation of membrane potential (GO:0045838)2.66655449
125G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65696841
126rRNA catabolic process (GO:0016075)2.64744026
127cranial nerve structural organization (GO:0021604)2.64137097
128oligodendrocyte differentiation (GO:0048709)2.64042436
129regulation of hexokinase activity (GO:1903299)2.63446366
130regulation of glucokinase activity (GO:0033131)2.63446366
131replication fork processing (GO:0031297)2.62815906
132regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.62575791
133signal peptide processing (GO:0006465)2.60430618
134ionotropic glutamate receptor signaling pathway (GO:0035235)2.59263881
135startle response (GO:0001964)2.59156758
136proline transport (GO:0015824)2.59050154
137vocalization behavior (GO:0071625)2.58232842
138amino acid import (GO:0043090)2.57702725
139transmission of nerve impulse (GO:0019226)2.57371895
140regulation of meiosis I (GO:0060631)2.57033332
141phosphatidylinositol acyl-chain remodeling (GO:0036149)2.56998767
142cilium organization (GO:0044782)2.56728442
143inositol phosphate catabolic process (GO:0071545)2.56720318
144cerebral cortex radially oriented cell migration (GO:0021799)2.56346534
145regulation of development, heterochronic (GO:0040034)2.54433992
146RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.54235975
147positive regulation of protein tyrosine kinase activity (GO:0061098)2.53996490
148positive regulation of dendritic spine development (GO:0060999)2.53867285
149glutamate receptor signaling pathway (GO:0007215)2.53727629
150* sensory perception (GO:0007600)2.53155196
151inner ear receptor stereocilium organization (GO:0060122)2.53083495
152mannosylation (GO:0097502)2.52179155
153multicellular organism reproduction (GO:0032504)2.51900896
154metanephric nephron tubule development (GO:0072234)2.51658441
155metanephric tubule development (GO:0072170)2.51658441
156membrane assembly (GO:0071709)2.51373187
157regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.51232524
158endothelium development (GO:0003158)2.50518920
159dopamine transport (GO:0015872)2.50492995
160detection of mechanical stimulus involved in sensory perception (GO:0050974)2.50173260
161dendritic spine morphogenesis (GO:0060997)2.50126633
162aromatic amino acid family catabolic process (GO:0009074)2.49992602
163adult feeding behavior (GO:0008343)2.49567176
164benzene-containing compound metabolic process (GO:0042537)2.49299636
165cilium or flagellum-dependent cell motility (GO:0001539)2.49157295
166regulation of action potential (GO:0098900)2.47749335
167protein localization to cilium (GO:0061512)2.47668863
168cilium assembly (GO:0042384)2.47394437
169establishment of protein localization to Golgi (GO:0072600)2.47263924
170negative regulation of neurotransmitter secretion (GO:0046929)2.47013541
171positive regulation of cGMP biosynthetic process (GO:0030828)2.46759368
172cilium movement (GO:0003341)2.46399409
173protein-cofactor linkage (GO:0018065)2.46324998
174polyol catabolic process (GO:0046174)2.45977180
175regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.45691042
176negative regulation of DNA-dependent DNA replication (GO:2000104)2.45582378
177oxidative demethylation (GO:0070989)2.45517538
178prenylation (GO:0097354)2.45195022
179protein prenylation (GO:0018342)2.45195022
180primary amino compound metabolic process (GO:1901160)2.44742129
181regulation of neurotransmitter uptake (GO:0051580)2.44035848
182regulation of voltage-gated calcium channel activity (GO:1901385)2.43951422
183negative regulation of translation, ncRNA-mediated (GO:0040033)2.43787082
184regulation of translation, ncRNA-mediated (GO:0045974)2.43787082
185negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.43787082
186adaptation of signaling pathway (GO:0023058)2.42700343
187axoneme assembly (GO:0035082)2.41266285
188keratinocyte development (GO:0003334)2.39006097
189gamma-aminobutyric acid signaling pathway (GO:0007214)2.38205264
190synaptic transmission, dopaminergic (GO:0001963)2.36974646
191positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.36415360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.83942046
2ZNF274_21170338_ChIP-Seq_K562_Hela3.66315309
3GBX2_23144817_ChIP-Seq_PC3_Human3.28204762
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00414938
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.74543819
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71490626
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71411219
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.59350394
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.52874735
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50628537
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50628537
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48896046
13VDR_22108803_ChIP-Seq_LS180_Human2.45054249
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41869523
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39240567
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35803840
17TAF15_26573619_Chip-Seq_HEK293_Human2.35512303
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33332205
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.31712858
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.25228866
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17597387
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.15960214
23EWS_26573619_Chip-Seq_HEK293_Human2.12571535
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.10469304
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02934252
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01882866
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99010848
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.92762988
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.90114836
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.86601747
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83174602
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78916678
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78655660
34* AR_21572438_ChIP-Seq_LNCaP_Human1.78654823
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73658009
36RNF2_27304074_Chip-Seq_NSC_Mouse1.69564624
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68666422
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67259014
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65542794
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62713004
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60376967
42P300_19829295_ChIP-Seq_ESCs_Human1.59557598
43CBP_20019798_ChIP-Seq_JUKART_Human1.57215199
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57215199
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55254612
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.54481688
47TCF4_23295773_ChIP-Seq_U87_Human1.52605221
48ER_23166858_ChIP-Seq_MCF-7_Human1.50311248
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.48123753
50* AR_25329375_ChIP-Seq_VCAP_Human1.47766133
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46914242
52TP53_22573176_ChIP-Seq_HFKS_Human1.45337755
53* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45127300
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.44990157
55IGF1R_20145208_ChIP-Seq_DFB_Human1.44726559
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.41585138
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41538242
58* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38843360
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38118700
60IRF1_19129219_ChIP-ChIP_H3396_Human1.36246994
61NANOG_19829295_ChIP-Seq_ESCs_Human1.35774464
62SOX2_19829295_ChIP-Seq_ESCs_Human1.35774464
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.35179726
64TCF4_22108803_ChIP-Seq_LS180_Human1.35060956
65SMAD4_21799915_ChIP-Seq_A2780_Human1.34749277
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34515316
67REST_21632747_ChIP-Seq_MESCs_Mouse1.33432742
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31338637
69FUS_26573619_Chip-Seq_HEK293_Human1.31200095
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30880182
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.30234363
72* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29936632
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29101798
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28881437
75* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28330334
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27685732
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.27685732
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25675468
79* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25075543
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24754401
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24242564
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23439114
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22004436
84DROSHA_22980978_ChIP-Seq_HELA_Human1.20999695
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20215023
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.19622098
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19084759
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19019899
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.18744133
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.18299489
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.17400282
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17375559
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.17307949
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.17157781
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17040519
96GABP_17652178_ChIP-ChIP_JURKAT_Human1.16024519
97* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16021169
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14998025
99P300_18555785_Chip-Seq_ESCs_Mouse1.14846786
100MYC_18940864_ChIP-ChIP_HL60_Human1.14272595
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.13282944
102P53_22387025_ChIP-Seq_ESCs_Mouse1.12182982
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11968396
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.11864380
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10943706
106SMAD3_21741376_ChIP-Seq_HESCs_Human1.10654552
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10274321
108RUNX2_22187159_ChIP-Seq_PCA_Human1.08846221
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.08812314
110* CDX2_22108803_ChIP-Seq_LS180_Human1.08559241
111* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08266486
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07997571
113GATA3_21878914_ChIP-Seq_MCF-7_Human1.07892172
114* NCOR_22424771_ChIP-Seq_293T_Human1.07216684
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06303532
116* AR_20517297_ChIP-Seq_VCAP_Human1.06254483
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06155241
118EST1_17652178_ChIP-ChIP_JURKAT_Human1.05876653
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05582179
120ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04943467
121EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04843599
122TP53_18474530_ChIP-ChIP_U2OS_Human1.03775067
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03702477
124* HOXB7_26014856_ChIP-Seq_BT474_Human1.03580176
125KDM2B_26808549_Chip-Seq_REH_Human1.03047640
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03025774
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02323535
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.01621169
129RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01160958
130SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00991319
131SOX2_18555785_Chip-Seq_ESCs_Mouse1.00101620
132KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00091997
133OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99402865
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99126878
135TAL1_26923725_Chip-Seq_HPCs_Mouse0.98737860
136NMYC_18555785_Chip-Seq_ESCs_Mouse0.98677782
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98566505
138STAT3_18555785_Chip-Seq_ESCs_Mouse0.98403236
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96700386
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96700386
141KLF4_18555785_Chip-Seq_ESCs_Mouse0.95890978
142BCAT_22108803_ChIP-Seq_LS180_Human0.95851934
143REST_18959480_ChIP-ChIP_MESCs_Mouse0.95236324
144* STAT3_23295773_ChIP-Seq_U87_Human0.94845205
145AHR_22903824_ChIP-Seq_MCF-7_Human0.92051764
146OCT4_18555785_Chip-Seq_ESCs_Mouse0.92023293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation6.33726935
2MP0003136_yellow_coat_color5.22916381
3* MP0005551_abnormal_eye_electrophysiolog5.04829162
4MP0005409_darkened_coat_color4.01295358
5MP0006072_abnormal_retinal_apoptosis3.72295318
6MP0005253_abnormal_eye_physiology3.59733870
7MP0003880_abnormal_central_pattern3.49983927
8MP0001188_hyperpigmentation3.44554002
9MP0004381_abnormal_hair_follicle3.12805360
10MP0003195_calcinosis3.04729016
11MP0009379_abnormal_foot_pigmentation2.97140862
12MP0008877_abnormal_DNA_methylation2.83800796
13MP0000569_abnormal_digit_pigmentation2.80073322
14MP0005423_abnormal_somatic_nervous2.68393339
15MP0002837_dystrophic_cardiac_calcinosis2.42524040
16MP0002102_abnormal_ear_morphology2.30010214
17MP0003950_abnormal_plasma_membrane2.28938153
18* MP0005195_abnormal_posterior_eye2.22942984
19MP0005646_abnormal_pituitary_gland2.17035119
20MP0006292_abnormal_olfactory_placode2.07496113
21MP0004742_abnormal_vestibular_system1.99684685
22MP0002638_abnormal_pupillary_reflex1.97511039
23MP0001486_abnormal_startle_reflex1.94173543
24MP0003646_muscle_fatigue1.93422044
25MP0008875_abnormal_xenobiotic_pharmacok1.89502856
26MP0004147_increased_porphyrin_level1.89007755
27MP0000372_irregular_coat_pigmentation1.87360125
28MP0003787_abnormal_imprinting1.82475505
29* MP0002229_neurodegeneration1.78679034
30MP0008872_abnormal_physiological_respon1.78438062
31MP0004270_analgesia1.77487819
32MP0001968_abnormal_touch/_nociception1.77410395
33MP0005391_vision/eye_phenotype1.75813661
34MP0002272_abnormal_nervous_system1.75024857
35MP0001986_abnormal_taste_sensitivity1.73615781
36MP0000427_abnormal_hair_cycle1.73230075
37* MP0002752_abnormal_somatic_nervous1.71871350
38MP0004043_abnormal_pH_regulation1.71828126
39MP0001324_abnormal_eye_pigmentation1.66118744
40MP0002938_white_spotting1.61346977
41MP0002064_seizures1.51577336
42MP0009745_abnormal_behavioral_response1.48620220
43MP0000920_abnormal_myelination1.47178391
44MP0009046_muscle_twitch1.46738057
45MP0002090_abnormal_vision1.45530961
46MP0003635_abnormal_synaptic_transmissio1.44107811
47MP0002163_abnormal_gland_morphology1.43307676
48MP0004133_heterotaxia1.42091954
49* MP0002882_abnormal_neuron_morphology1.38168405
50MP0000778_abnormal_nervous_system1.37533771
51MP0005379_endocrine/exocrine_gland_phen1.35769769
52MP0000015_abnormal_ear_pigmentation1.35482492
53MP0002734_abnormal_mechanical_nocicepti1.34696269
54MP0004142_abnormal_muscle_tone1.33019553
55MP0002067_abnormal_sensory_capabilities1.32137587
56MP0006276_abnormal_autonomic_nervous1.28101722
57MP0009780_abnormal_chondrocyte_physiolo1.26698772
58MP0003938_abnormal_ear_development1.26060342
59MP0001905_abnormal_dopamine_level1.25216586
60MP0005084_abnormal_gallbladder_morpholo1.23994660
61MP0005075_abnormal_melanosome_morpholog1.23960003
62MP0000026_abnormal_inner_ear1.23844424
63MP0005171_absent_coat_pigmentation1.22906577
64MP0010386_abnormal_urinary_bladder1.22390233
65MP0004885_abnormal_endolymph1.20185786
66MP0005386_behavior/neurological_phenoty1.19688769
67MP0004924_abnormal_behavior1.19688769
68MP0002653_abnormal_ependyma_morphology1.18332221
69MP0004859_abnormal_synaptic_plasticity1.17154329
70MP0002572_abnormal_emotion/affect_behav1.16037028
71MP0002095_abnormal_skin_pigmentation1.15750422
72MP0000566_synostosis1.14400432
73MP0001963_abnormal_hearing_physiology1.13291110
74MP0005174_abnormal_tail_pigmentation1.12949955
75MP0001970_abnormal_pain_threshold1.09667385
76MP0002234_abnormal_pharynx_morphology1.07185675
77MP0008058_abnormal_DNA_repair1.04424336
78MP0002928_abnormal_bile_duct1.03937759
79MP0003718_maternal_effect1.02597567
80MP0001440_abnormal_grooming_behavior1.01514181
81MP0005389_reproductive_system_phenotype1.01439266
82MP0000631_abnormal_neuroendocrine_gland1.00631187
83MP0003634_abnormal_glial_cell1.00138052
84MP0002249_abnormal_larynx_morphology0.99518804
85MP0002160_abnormal_reproductive_system0.98241942
86MP0008995_early_reproductive_senescence0.95977091
87MP0002177_abnormal_outer_ear0.95091267
88MP0002184_abnormal_innervation0.95085947
89MP0002557_abnormal_social/conspecific_i0.93926662
90MP0004215_abnormal_myocardial_fiber0.93372028
91MP0002063_abnormal_learning/memory/cond0.92874644
92MP0002254_reproductive_system_inflammat0.92690080
93MP0000230_abnormal_systemic_arterial0.92577885
94MP0005167_abnormal_blood-brain_barrier0.92256456
95MP0004145_abnormal_muscle_electrophysio0.91107759
96MP0001502_abnormal_circadian_rhythm0.90834419
97MP0005085_abnormal_gallbladder_physiolo0.90001634
98MP0005410_abnormal_fertilization0.89579510
99MP0002735_abnormal_chemical_nociception0.89256057
100MP0003315_abnormal_perineum_morphology0.89100824
101MP0008260_abnormal_autophagy0.88903318
102MP0003121_genomic_imprinting0.87655370
103MP0009250_abnormal_appendicular_skeleto0.87358437
104MP0001764_abnormal_homeostasis0.86066282
105MP0003724_increased_susceptibility_to0.85438445
106MP0003698_abnormal_male_reproductive0.84967065
107MP0002909_abnormal_adrenal_gland0.84334268
108MP0005595_abnormal_vascular_smooth0.84093227
109MP0002693_abnormal_pancreas_physiology0.83517194
110MP0001501_abnormal_sleep_pattern0.83128746
111MP0000049_abnormal_middle_ear0.82646616
112MP0008057_abnormal_DNA_replication0.80384608
113MP0001661_extended_life_span0.78348706
114MP0001919_abnormal_reproductive_system0.78226041
115MP0003283_abnormal_digestive_organ0.77747897
116MP0003937_abnormal_limbs/digits/tail_de0.77340494
117MP0008569_lethality_at_weaning0.76247675
118MP0002751_abnormal_autonomic_nervous0.75911413
119MP0002277_abnormal_respiratory_mucosa0.75860174
120MP0005332_abnormal_amino_acid0.75631721
121MP0001929_abnormal_gametogenesis0.75224460
122MP0001529_abnormal_vocalization0.74898845
123MP0000647_abnormal_sebaceous_gland0.74597242
124MP0002733_abnormal_thermal_nociception0.73230425
125MP0002066_abnormal_motor_capabilities/c0.71916839
126MP0000762_abnormal_tongue_morphology0.71097880
127MP0000579_abnormal_nail_morphology0.70424325
128MP0001286_abnormal_eye_development0.68393271
129MP0008789_abnormal_olfactory_epithelium0.68028117
130MP0005394_taste/olfaction_phenotype0.67145205
131MP0005499_abnormal_olfactory_system0.67145205
132MP0002736_abnormal_nociception_after0.64963641
133MP0001984_abnormal_olfaction0.64764546
134MP0001340_abnormal_eyelid_morphology0.64437039
135MP0000955_abnormal_spinal_cord0.63953595
136MP0000467_abnormal_esophagus_morphology0.62900251
137MP0001346_abnormal_lacrimal_gland0.62819542
138MP0004019_abnormal_vitamin_homeostasis0.62800338
139MP0001485_abnormal_pinna_reflex0.61781711
140MP0005257_abnormal_intraocular_pressure0.61145554
141* MP0002152_abnormal_brain_morphology0.59857166
142MP0003385_abnormal_body_wall0.58796628
143MP0000462_abnormal_digestive_system0.57766905
144MP0005197_abnormal_uvea_morphology0.57270435
145MP0001664_abnormal_digestion0.57078734
146MP0000383_abnormal_hair_follicle0.56824504
147MP0002876_abnormal_thyroid_physiology0.55279914
148MP0000613_abnormal_salivary_gland0.54190620
149MP0005645_abnormal_hypothalamus_physiol0.51858700

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)9.21518192
2Absent rod-and cone-mediated responses on ERG (HP:0007688)7.69312242
3Bony spicule pigmentary retinopathy (HP:0007737)7.63615972
4Abnormal rod and cone electroretinograms (HP:0008323)6.91440285
5Dyschromatopsia (HP:0007641)6.02025226
6Decreased central vision (HP:0007663)5.46789296
7Abnormality of macular pigmentation (HP:0008002)5.25164335
8* Attenuation of retinal blood vessels (HP:0007843)5.00297912
9Central scotoma (HP:0000603)4.77432465
10Chorioretinal atrophy (HP:0000533)4.73076590
11Pigmentary retinal degeneration (HP:0001146)4.65930255
12Abolished electroretinogram (ERG) (HP:0000550)4.62367217
13Pancreatic cysts (HP:0001737)4.57780500
14Scotoma (HP:0000575)4.54370489
15Pendular nystagmus (HP:0012043)4.51171629
16Pancreatic fibrosis (HP:0100732)4.08280047
17Increased corneal curvature (HP:0100692)4.07139767
18Keratoconus (HP:0000563)4.07139767
19Molar tooth sign on MRI (HP:0002419)4.06470378
20Abnormality of midbrain morphology (HP:0002418)4.06470378
21* Photophobia (HP:0000613)3.64932068
22Severe visual impairment (HP:0001141)3.53904565
23Abnormality of the renal cortex (HP:0011035)3.40753400
24Retinitis pigmentosa (HP:0000510)3.28503887
25Macular degeneration (HP:0000608)3.28100435
26Abnormality of the renal medulla (HP:0100957)3.27460352
27Cone-rod dystrophy (HP:0000548)3.22534817
28Choroideremia (HP:0001139)3.20156938
29Abnormality of the axillary hair (HP:0100134)3.16564376
30Abnormality of secondary sexual hair (HP:0009888)3.16564376
31Type II lissencephaly (HP:0007260)3.12374546
32* Optic disc pallor (HP:0000543)3.06429258
33Congenital sensorineural hearing impairment (HP:0008527)3.04709495
34* Type II diabetes mellitus (HP:0005978)2.99101655
35Gaze-evoked nystagmus (HP:0000640)2.95309966
36Abnormal sex determination (HP:0012244)2.83196396
37Sex reversal (HP:0012245)2.83196396
38Cystic liver disease (HP:0006706)2.81916496
39Chronic hepatic failure (HP:0100626)2.74053815
40Vitreoretinal degeneration (HP:0000655)2.73510063
41Abnormal ciliary motility (HP:0012262)2.69127347
42Parakeratosis (HP:0001036)2.65635306
43Tubular atrophy (HP:0000092)2.64492562
44Absent/shortened dynein arms (HP:0200106)2.62445713
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.62445713
46Focal motor seizures (HP:0011153)2.60851223
47Large for gestational age (HP:0001520)2.59012711
48Inability to walk (HP:0002540)2.44318114
49Progressive inability to walk (HP:0002505)2.43998403
50Septo-optic dysplasia (HP:0100842)2.43412150
51Decreased electroretinogram (ERG) amplitude (HP:0000654)2.38463425
52Renal cortical cysts (HP:0000803)2.37454396
53Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.36541566
54Constricted visual fields (HP:0001133)2.35995333
55Polydipsia (HP:0001959)2.35809381
56Abnormal drinking behavior (HP:0030082)2.35809381
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.34370688
58Intestinal atresia (HP:0011100)2.31830520
59Sensory axonal neuropathy (HP:0003390)2.31490356
60Furrowed tongue (HP:0000221)2.31383360
61Abnormal respiratory motile cilium physiology (HP:0012261)2.26101562
62Cerebellar dysplasia (HP:0007033)2.25909291
63Concave nail (HP:0001598)2.23060154
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.22100408
65Sclerocornea (HP:0000647)2.21489870
66Lissencephaly (HP:0001339)2.20415968
67Hypothermia (HP:0002045)2.20299334
68Gait imbalance (HP:0002141)2.19618050
69Abnormality of the pons (HP:0007361)2.19063318
70Alacrima (HP:0000522)2.18700692
71Broad-based gait (HP:0002136)2.18347745
72Peripheral hypomyelination (HP:0007182)2.16479895
73Obstructive sleep apnea (HP:0002870)2.16308575
74Stomach cancer (HP:0012126)2.13999974
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11974758
76Abnormality of alanine metabolism (HP:0010916)2.11974758
77Hyperalaninemia (HP:0003348)2.11974758
78Medial flaring of the eyebrow (HP:0010747)2.11757675
79Volvulus (HP:0002580)2.10722665
80Absent septum pellucidum (HP:0001331)2.10240271
81Fair hair (HP:0002286)2.08500775
82Methylmalonic acidemia (HP:0002912)2.06591963
83Degeneration of the lateral corticospinal tracts (HP:0002314)2.06469624
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06469624
85Congenital primary aphakia (HP:0007707)2.06454733
86Hypoplasia of the pons (HP:0012110)2.05615919
87Widely spaced teeth (HP:0000687)2.04540532
88Anencephaly (HP:0002323)2.03597619
89Genetic anticipation (HP:0003743)2.02724727
90Decreased circulating renin level (HP:0003351)2.01569006
91Abnormal biliary tract physiology (HP:0012439)2.01363870
92Bile duct proliferation (HP:0001408)2.01363870
93Vaginal atresia (HP:0000148)2.00867690
94Abnormality of the septum pellucidum (HP:0007375)2.00774336
95Increased CSF lactate (HP:0002490)1.99322306
96Absent speech (HP:0001344)1.98690823
97Polyuria (HP:0000103)1.97477109
98Protruding tongue (HP:0010808)1.97386487
99Abnormal respiratory epithelium morphology (HP:0012253)1.96829401
100Abnormal respiratory motile cilium morphology (HP:0005938)1.96829401
101Congenital hepatic fibrosis (HP:0002612)1.95827357
102Genital tract atresia (HP:0001827)1.95408796
103Ketoacidosis (HP:0001993)1.93906545
104Acute necrotizing encephalopathy (HP:0006965)1.93759947
105Neurofibrillary tangles (HP:0002185)1.93336047
106Abnormality of the labia minora (HP:0012880)1.92862434
107Small hand (HP:0200055)1.92021721
108Optic nerve hypoplasia (HP:0000609)1.91707342
109Progressive macrocephaly (HP:0004481)1.91506351
110Methylmalonic aciduria (HP:0012120)1.90998791
111Congenital, generalized hypertrichosis (HP:0004540)1.90612921
112Chin dimple (HP:0010751)1.88790281
113Mitochondrial inheritance (HP:0001427)1.88702146
114Split foot (HP:0001839)1.88547782
115Esotropia (HP:0000565)1.88456159
116Severe muscular hypotonia (HP:0006829)1.85617518
117Male pseudohermaphroditism (HP:0000037)1.85234176
118Short tibia (HP:0005736)1.84483272
119Postaxial foot polydactyly (HP:0001830)1.82686500
120Dialeptic seizures (HP:0011146)1.82518363
121Aplasia/Hypoplasia of the lens (HP:0008063)1.82462429
122Thyroiditis (HP:0100646)1.82348022
123Aplasia/Hypoplasia of the uvula (HP:0010293)1.81845208
124Focal seizures (HP:0007359)1.81545182
1253-Methylglutaconic aciduria (HP:0003535)1.81143683
126Hypophosphatemic rickets (HP:0004912)1.79175201
127Ketosis (HP:0001946)1.77871270
128Hypoproteinemia (HP:0003075)1.76675845
129Decreased lacrimation (HP:0000633)1.76355410
130Nephrogenic diabetes insipidus (HP:0009806)1.76137480
131Epileptic encephalopathy (HP:0200134)1.75869641
132Prolonged partial thromboplastin time (HP:0003645)1.74490737
133Clumsiness (HP:0002312)1.74456919
134Astigmatism (HP:0000483)1.73116684
135Renal Fanconi syndrome (HP:0001994)1.72569156
136Retinal atrophy (HP:0001105)1.72455032
137Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71903003
138Progressive visual loss (HP:0000529)1.71284602
139Febrile seizures (HP:0002373)1.70398192
140Retinal dysplasia (HP:0007973)1.69502322
141Aplasia/Hypoplasia of the tibia (HP:0005772)1.69497452
142Thyroid-stimulating hormone excess (HP:0002925)1.68380667
143Increased hepatocellular lipid droplets (HP:0006565)1.67900784
144Overfolded helix (HP:0000396)1.64740339
145Progressive cerebellar ataxia (HP:0002073)1.62519933
146Nephronophthisis (HP:0000090)1.62227866
147Ulnar claw (HP:0001178)1.59522307
148White forelock (HP:0002211)1.57954495
149Posterior subcapsular cataract (HP:0007787)1.57828635
150Nasolacrimal duct obstruction (HP:0000579)1.56385307
151Nonprogressive disorder (HP:0003680)1.56245474
152Hyperventilation (HP:0002883)1.56229823
153Corneal dystrophy (HP:0001131)1.55738948
154Aplasia cutis congenita (HP:0001057)1.55292375
155True hermaphroditism (HP:0010459)1.54958016
156Hemiparesis (HP:0001269)1.52967639
157Stage 5 chronic kidney disease (HP:0003774)1.52723302
158Dysdiadochokinesis (HP:0002075)1.50908338
159Hypomagnesemia (HP:0002917)1.50855880
160Aplasia/Hypoplasia of the fovea (HP:0008060)1.50063855
161Hypoplasia of the fovea (HP:0007750)1.50063855
162Thickened helices (HP:0000391)1.49659955
163Dysmetria (HP:0001310)1.49515327
164Onion bulb formation (HP:0003383)1.48876753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.76410598
2CASK6.68825079
3GRK14.22850215
4MKNK24.04236638
5MAP4K23.09102443
6TLK12.83163282
7ZAK2.70443159
8STK392.70393219
9ACVR1B2.54824850
10BLK2.54596944
11WNK32.53990490
12NUAK12.52522986
13TNIK2.33875604
14PBK2.17069679
15FES2.13836531
16MKNK12.10036810
17PNCK2.08703691
18PKN12.03761962
19PHKG22.01921964
20PHKG12.01921964
21OXSR11.73941463
22MAPK131.53367652
23IRAK21.51887206
24TXK1.45165528
25DAPK21.35686199
26TRIM281.32482220
27MAPK151.30994440
28MUSK1.29325286
29INSRR1.29009857
30PAK31.26895767
31FGR1.25840493
32GRK51.18417260
33WNK41.13369295
34GRK71.12716215
35STK161.12125965
36NTRK31.11308717
37EPHA41.07474600
38IRAK11.06235976
39CAMK2B1.04904563
40STK38L1.03903991
41TGFBR10.99504680
42UHMK10.98573727
43PRKD20.98079538
44FER0.97841001
45CDK190.97380700
46MAP2K60.96942355
47CLK10.95532530
48PRPF4B0.94339200
49TAOK30.94113739
50TEC0.93855189
51DYRK1A0.93635249
52MAPK120.93372302
53WNK10.92329604
54KIT0.90760744
55TIE10.90004257
56MAP2K70.89550735
57NEK60.86247097
58CAMK2D0.86105466
59ADRBK20.85605399
60CAMK2A0.85115259
61MARK10.83393048
62MAPKAPK50.82837022
63PRKCG0.81387191
64MST40.81021341
65ROCK20.80187507
66PRKAA20.80001831
67YES10.78744424
68PIK3CG0.77416178
69PTK2B0.76727122
70FGFR20.76455177
71VRK10.74950121
72BMPR1B0.73599318
73MAPKAPK30.73438960
74EPHB20.72436221
75CSNK1G10.71973544
76ADRBK10.71387019
77ERBB30.70691848
78CDK30.70225117
79MARK20.68634286
80BCR0.68397562
81PIK3CA0.68298886
82PAK20.68148271
83CSNK1A1L0.68116567
84NME10.67962297
85STK30.67807901
86DYRK20.67559663
87IKBKB0.67452222
88CSNK1G30.66988016
89BCKDK0.66199754
90EPHA30.66024556
91NTRK20.65647132
92CAMKK20.65419773
93HIPK20.64907133
94CAMK10.64809901
95PRKCE0.64766325
96CAMK1G0.64558360
97PRKG10.63341906
98SIK20.62952253
99EIF2AK30.62771938
100BRSK20.62601033
101PLK30.61136120
102AKT30.59366369
103CDK50.58477698
104PAK60.58254988
105CSNK1G20.57476445
106SRPK10.57061617
107CAMK2G0.56828976
108CSNK1D0.53925379
109BMPR20.53125001
110EPHB10.52344207
111STK110.51943869
112VRK20.49757127
113LATS10.47769551
114PRKACA0.47347294
115TNK20.46426865
116NLK0.46029781
117PRKD10.45761685
118OBSCN0.45161805
119MAP2K20.44165555
120TRPM70.43680785
121FLT30.43120187
122RPS6KA50.41831095
123CSK0.40836029
124CSNK1A10.40763262
125MAP3K10.40513304
126PRKCI0.38702389
127PLK40.37739884
128RIPK40.36992567
129TAF10.36934033
130NME20.36508934
131PRKCQ0.35879577
132FYN0.34528131
133PLK20.33453948
134NTRK10.33230750
135PRKCA0.32611001
136MARK30.32172481
137CHUK0.31815799
138CSNK1E0.31713131
139MAP3K40.30625308
140PINK10.30564771
141EIF2AK20.30424183
142SGK4940.30401374
143SGK2230.30401374
144DAPK30.29634789
145PRKAA10.29412768
146NEK20.29302026
147CDK140.28950968

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.51457585
2Butanoate metabolism_Homo sapiens_hsa006502.42798640
3Nicotine addiction_Homo sapiens_hsa050332.34885790
4Homologous recombination_Homo sapiens_hsa034402.03958148
5Tryptophan metabolism_Homo sapiens_hsa003802.03026643
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01999293
7* Phototransduction_Homo sapiens_hsa0474410.2659615
8Caffeine metabolism_Homo sapiens_hsa002321.97048120
9Oxidative phosphorylation_Homo sapiens_hsa001901.94850831
10Selenocompound metabolism_Homo sapiens_hsa004501.92365194
11Glutamatergic synapse_Homo sapiens_hsa047241.87586965
12GABAergic synapse_Homo sapiens_hsa047271.85433654
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.83368694
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82964989
15Fatty acid elongation_Homo sapiens_hsa000621.79810191
16Serotonergic synapse_Homo sapiens_hsa047261.79572145
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73215948
18Morphine addiction_Homo sapiens_hsa050321.69246684
19Ether lipid metabolism_Homo sapiens_hsa005651.66559726
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58293316
21Basal transcription factors_Homo sapiens_hsa030221.57477006
22Propanoate metabolism_Homo sapiens_hsa006401.57315206
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56198984
24RNA polymerase_Homo sapiens_hsa030201.55098319
25Axon guidance_Homo sapiens_hsa043601.52056901
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.41118643
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.38807027
28Taste transduction_Homo sapiens_hsa047421.36169557
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36046927
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33186935
31Sphingolipid metabolism_Homo sapiens_hsa006001.32938583
32Cardiac muscle contraction_Homo sapiens_hsa042601.32397415
33Long-term depression_Homo sapiens_hsa047301.32006862
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29833630
35Alzheimers disease_Homo sapiens_hsa050101.29296581
36Salivary secretion_Homo sapiens_hsa049701.22137625
37Protein export_Homo sapiens_hsa030601.21944129
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21449522
39Circadian entrainment_Homo sapiens_hsa047131.17769693
40Sulfur metabolism_Homo sapiens_hsa009201.16687934
41Parkinsons disease_Homo sapiens_hsa050121.16276934
42Chemical carcinogenesis_Homo sapiens_hsa052041.15768431
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15105924
44Peroxisome_Homo sapiens_hsa041461.12145593
45RNA degradation_Homo sapiens_hsa030181.08739089
46Olfactory transduction_Homo sapiens_hsa047401.07459932
47Cholinergic synapse_Homo sapiens_hsa047251.07010493
48Linoleic acid metabolism_Homo sapiens_hsa005911.05138901
49Retinol metabolism_Homo sapiens_hsa008301.04907586
50Synaptic vesicle cycle_Homo sapiens_hsa047211.04555300
51One carbon pool by folate_Homo sapiens_hsa006701.01415236
52Arachidonic acid metabolism_Homo sapiens_hsa005900.98785255
53Renin secretion_Homo sapiens_hsa049240.98217092
54Calcium signaling pathway_Homo sapiens_hsa040200.97412548
55Dopaminergic synapse_Homo sapiens_hsa047280.93595607
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92152203
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.89678814
58Regulation of autophagy_Homo sapiens_hsa041400.89436758
59Glycerolipid metabolism_Homo sapiens_hsa005610.87327275
60Huntingtons disease_Homo sapiens_hsa050160.87308127
61Non-homologous end-joining_Homo sapiens_hsa034500.87273079
62Cocaine addiction_Homo sapiens_hsa050300.86253060
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86044043
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86026508
65Ribosome_Homo sapiens_hsa030100.84389632
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83348367
67Melanogenesis_Homo sapiens_hsa049160.83283027
68beta-Alanine metabolism_Homo sapiens_hsa004100.81771150
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80068081
70Insulin secretion_Homo sapiens_hsa049110.76186316
71Steroid biosynthesis_Homo sapiens_hsa001000.74432018
72Oxytocin signaling pathway_Homo sapiens_hsa049210.73118533
73Ras signaling pathway_Homo sapiens_hsa040140.72812107
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70627489
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.70239156
76Gastric acid secretion_Homo sapiens_hsa049710.70211097
77Wnt signaling pathway_Homo sapiens_hsa043100.70097746
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69923201
79Amphetamine addiction_Homo sapiens_hsa050310.69196382
80cAMP signaling pathway_Homo sapiens_hsa040240.69185046
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66154687
82Pancreatic secretion_Homo sapiens_hsa049720.65803569
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65348270
84Fatty acid degradation_Homo sapiens_hsa000710.64638703
85Metabolic pathways_Homo sapiens_hsa011000.63182155
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62843224
87Long-term potentiation_Homo sapiens_hsa047200.62471155
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62308882
89Histidine metabolism_Homo sapiens_hsa003400.62176622
90* Purine metabolism_Homo sapiens_hsa002300.62090414
91Fat digestion and absorption_Homo sapiens_hsa049750.62087458
92Collecting duct acid secretion_Homo sapiens_hsa049660.60026630
93Hedgehog signaling pathway_Homo sapiens_hsa043400.59509891
94ABC transporters_Homo sapiens_hsa020100.57563249
95Primary immunodeficiency_Homo sapiens_hsa053400.55146903
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54184300
97GnRH signaling pathway_Homo sapiens_hsa049120.53180940
98Circadian rhythm_Homo sapiens_hsa047100.52945109
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52409831
100Type I diabetes mellitus_Homo sapiens_hsa049400.52375469
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51487276
102Mineral absorption_Homo sapiens_hsa049780.51435299
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51027230
104Gap junction_Homo sapiens_hsa045400.49548864
105Autoimmune thyroid disease_Homo sapiens_hsa053200.48891526
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48648624
107Asthma_Homo sapiens_hsa053100.48245273
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48064905
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47837999
110Proteasome_Homo sapiens_hsa030500.46795585
111Ovarian steroidogenesis_Homo sapiens_hsa049130.46740008
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46614770
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.45670405
114Basal cell carcinoma_Homo sapiens_hsa052170.45536423
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.44419844
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44175699
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.42747113
118Fatty acid biosynthesis_Homo sapiens_hsa000610.42563843
119ErbB signaling pathway_Homo sapiens_hsa040120.42534227
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41427115
121Fatty acid metabolism_Homo sapiens_hsa012120.40859892
122Renal cell carcinoma_Homo sapiens_hsa052110.40579984
123Other glycan degradation_Homo sapiens_hsa005110.38753456
124MAPK signaling pathway_Homo sapiens_hsa040100.38344354
125Rheumatoid arthritis_Homo sapiens_hsa053230.37904858
126Vibrio cholerae infection_Homo sapiens_hsa051100.36900857
127Pyrimidine metabolism_Homo sapiens_hsa002400.36525709
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36064556
129Dilated cardiomyopathy_Homo sapiens_hsa054140.36017685
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.35708244
131Dorso-ventral axis formation_Homo sapiens_hsa043200.35664970
132Melanoma_Homo sapiens_hsa052180.35650138
133Graft-versus-host disease_Homo sapiens_hsa053320.33671438
134Choline metabolism in cancer_Homo sapiens_hsa052310.33318765
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33047250
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.32372505
137African trypanosomiasis_Homo sapiens_hsa051430.31760160
138Alcoholism_Homo sapiens_hsa050340.31321148
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.30808330
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30414736
141Tight junction_Homo sapiens_hsa045300.29149478
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27213639
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26316305
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26080433
145ECM-receptor interaction_Homo sapiens_hsa045120.26055135
146Fanconi anemia pathway_Homo sapiens_hsa034600.25803216
147Vitamin digestion and absorption_Homo sapiens_hsa049770.24967526
148Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24713846

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