PDE6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* detection of light stimulus (GO:0009583)9.91083449
2* detection of visible light (GO:0009584)9.75750293
3regulation of guanylate cyclase activity (GO:0031282)9.04666666
4* visual perception (GO:0007601)8.78663367
5* sensory perception of light stimulus (GO:0050953)8.68337778
6photoreceptor cell differentiation (GO:0046530)8.04830588
7eye photoreceptor cell differentiation (GO:0001754)8.04830588
8protein-chromophore linkage (GO:0018298)7.99230861
9* cellular response to light stimulus (GO:0071482)7.36553048
10* detection of external stimulus (GO:0009581)6.88991094
11* detection of abiotic stimulus (GO:0009582)6.75103614
12regulation of cGMP metabolic process (GO:0030823)6.65382764
13* retina development in camera-type eye (GO:0060041)6.39479985
14positive regulation of cGMP biosynthetic process (GO:0030828)5.94100506
15regulation of cGMP biosynthetic process (GO:0030826)5.57807463
16nonmotile primary cilium assembly (GO:0035058)5.27989269
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.24052441
18positive regulation of cGMP metabolic process (GO:0030825)5.23201489
19receptor guanylyl cyclase signaling pathway (GO:0007168)5.13589676
20* GMP metabolic process (GO:0046037)5.10708349
21cell morphogenesis involved in neuron differentiation (GO:0048667)4.91481830
22adaptation of signaling pathway (GO:0023058)4.80903530
23* cellular response to radiation (GO:0071478)4.71369612
24behavioral response to nicotine (GO:0035095)4.68001917
25positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.64787702
26detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.28726428
27protein prenylation (GO:0018342)4.26719304
28prenylation (GO:0097354)4.26719304
29regulation of clathrin-mediated endocytosis (GO:2000369)4.22567354
30regulation of voltage-gated calcium channel activity (GO:1901385)4.17502275
31* regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.14528126
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.10204552
33* sensory perception (GO:0007600)4.09852921
34protein polyglutamylation (GO:0018095)3.98128469
35negative regulation of receptor-mediated endocytosis (GO:0048261)3.87927065
36retina layer formation (GO:0010842)3.87258315
37neuron development (GO:0048666)3.86316465
38epithelial cilium movement (GO:0003351)3.82433818
39protein localization to synapse (GO:0035418)3.82285927
40* response to light stimulus (GO:0009416)3.80273892
41retina homeostasis (GO:0001895)3.75204192
42protein complex biogenesis (GO:0070271)3.57420623
43L-fucose catabolic process (GO:0042355)3.56666501
44fucose catabolic process (GO:0019317)3.56666501
45L-fucose metabolic process (GO:0042354)3.56666501
46estrogen biosynthetic process (GO:0006703)3.48126720
47negative regulation of cytosolic calcium ion concentration (GO:0051481)3.47537553
48platelet dense granule organization (GO:0060155)3.38320746
49short-term memory (GO:0007614)3.36366664
50positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.34925846
51regulation of short-term neuronal synaptic plasticity (GO:0048172)3.34429366
52cilium movement (GO:0003341)3.33761776
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.32127846
54regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.29230706
55regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.29230706
56mitochondrial respiratory chain complex I assembly (GO:0032981)3.21904706
57NADH dehydrogenase complex assembly (GO:0010257)3.21904706
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21904706
59cellular ketone body metabolic process (GO:0046950)3.20865486
60mitochondrial respiratory chain complex assembly (GO:0033108)3.20629436
61behavioral response to ethanol (GO:0048149)3.20111409
62chemosensory behavior (GO:0007635)3.17900472
63regulation of penile erection (GO:0060405)3.16514569
64regulation of cilium movement (GO:0003352)3.15199165
65positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.14701606
66respiratory chain complex IV assembly (GO:0008535)3.14506633
67positive regulation of sodium ion transmembrane transport (GO:1902307)3.13554870
68CDP-diacylglycerol biosynthetic process (GO:0016024)3.12981349
69response to pheromone (GO:0019236)3.10909718
70water-soluble vitamin biosynthetic process (GO:0042364)3.09499055
71peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.08151720
72tryptophan catabolic process (GO:0006569)3.07578667
73indole-containing compound catabolic process (GO:0042436)3.07578667
74indolalkylamine catabolic process (GO:0046218)3.07578667
75positive regulation of neurotransmitter transport (GO:0051590)3.07089392
76regulation of neurotransmitter uptake (GO:0051580)3.06072230
77cytochrome complex assembly (GO:0017004)3.04597539
78DNA deamination (GO:0045006)3.03592374
79response to histamine (GO:0034776)3.01909971
80membrane hyperpolarization (GO:0060081)2.96438679
81gamma-aminobutyric acid transport (GO:0015812)2.94117373
82kidney morphogenesis (GO:0060993)2.92452586
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.90474917
84CDP-diacylglycerol metabolic process (GO:0046341)2.90232202
85hindbrain development (GO:0030902)2.87370999
86axoneme assembly (GO:0035082)2.84753234
87negative regulation of telomere maintenance (GO:0032205)2.83658542
88negative regulation of transcription regulatory region DNA binding (GO:2000678)2.82471968
89ketone body metabolic process (GO:1902224)2.82304888
90indolalkylamine metabolic process (GO:0006586)2.81276698
91retinoid metabolic process (GO:0001523)2.80291459
92inositol phosphate catabolic process (GO:0071545)2.79917430
93synaptic vesicle maturation (GO:0016188)2.79481785
94arachidonic acid secretion (GO:0050482)2.76215442
95icosanoid secretion (GO:0032309)2.76215442
96cilium morphogenesis (GO:0060271)2.74128094
97phospholipid translocation (GO:0045332)2.72072260
98lipid translocation (GO:0034204)2.72072260
99membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.71853639
100tryptophan metabolic process (GO:0006568)2.71180889
101synaptic vesicle docking involved in exocytosis (GO:0016081)2.69638211
102axonemal dynein complex assembly (GO:0070286)2.69557070
103protein localization to cilium (GO:0061512)2.68334811
104cilium or flagellum-dependent cell motility (GO:0001539)2.68204187
105retinol metabolic process (GO:0042572)2.67783477
106preassembly of GPI anchor in ER membrane (GO:0016254)2.67724587
107negative regulation of cation channel activity (GO:2001258)2.67667373
108positive regulation of meiosis (GO:0045836)2.67614331
109mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65695608
110piRNA metabolic process (GO:0034587)2.65620487
111presynaptic membrane assembly (GO:0097105)2.65174043
112dentate gyrus development (GO:0021542)2.65074005
113dopamine receptor signaling pathway (GO:0007212)2.64814517
114neuronal action potential (GO:0019228)2.64610218
115negative regulation of calcium ion transmembrane transport (GO:1903170)2.64227385
116negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.64227385
117transmission of nerve impulse (GO:0019226)2.63944369
118lipoprotein transport (GO:0042953)2.63310251
119multicellular organism reproduction (GO:0032504)2.60010866
120* response to radiation (GO:0009314)2.59720304
121axon ensheathment in central nervous system (GO:0032291)2.59425974
122central nervous system myelination (GO:0022010)2.59425974
123diterpenoid metabolic process (GO:0016101)2.59309894
124negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.58309254
125G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56036200
126neuron fate determination (GO:0048664)2.56010851
127cilium organization (GO:0044782)2.55856740
128presynaptic membrane organization (GO:0097090)2.55032321
129intraciliary transport (GO:0042073)2.53602684
130positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.52874909
131mitochondrion transport along microtubule (GO:0047497)2.52356544
132establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.52356544
133negative regulation of appetite (GO:0032099)2.51680888
134negative regulation of response to food (GO:0032096)2.51680888
135glycerophospholipid catabolic process (GO:0046475)2.51201817
136nephron epithelium morphogenesis (GO:0072088)2.51161946
137nephron tubule morphogenesis (GO:0072078)2.51161946
138pyrimidine nucleobase catabolic process (GO:0006208)2.50797053
139mannosylation (GO:0097502)2.50043785
140cellular potassium ion homeostasis (GO:0030007)2.48110690
141positive regulation of oligodendrocyte differentiation (GO:0048714)2.47168347
142positive regulation of meiotic cell cycle (GO:0051446)2.46425456
143behavioral response to cocaine (GO:0048148)2.46280012
144regulation of meiosis I (GO:0060631)2.46031874
145cilium assembly (GO:0042384)2.45060066
146ubiquinone biosynthetic process (GO:0006744)2.44682710
147phosphorylated carbohydrate dephosphorylation (GO:0046838)2.44141194
148inositol phosphate dephosphorylation (GO:0046855)2.44141194
149regulation of action potential (GO:0098900)2.43929005
150kynurenine metabolic process (GO:0070189)2.43878259
151detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.41591768
152synaptic transmission, dopaminergic (GO:0001963)2.41500837
153post-embryonic morphogenesis (GO:0009886)2.40559928
154lactate metabolic process (GO:0006089)2.40485390
155regulation of glucokinase activity (GO:0033131)2.40476356
156regulation of hexokinase activity (GO:1903299)2.40476356
157sodium ion export (GO:0071436)2.39635719
158positive regulation of cyclase activity (GO:0031281)2.39525223
159positive regulation of amino acid transport (GO:0051957)2.39149740
160dopamine transport (GO:0015872)2.38772259
161spinal cord motor neuron differentiation (GO:0021522)2.38709807
162membrane depolarization during action potential (GO:0086010)2.38450565
163nucleobase catabolic process (GO:0046113)2.37166009
164terpenoid metabolic process (GO:0006721)2.36947783
165protein heterotetramerization (GO:0051290)2.36872004
166somite development (GO:0061053)2.36524187
167indole-containing compound metabolic process (GO:0042430)2.36090818
168aggressive behavior (GO:0002118)2.36003427
169* cellular response to abiotic stimulus (GO:0071214)2.35559626
170protein-cofactor linkage (GO:0018065)2.35223230
171tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.34865264
172RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.34865264
173positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.34809338
174* regulation of rhodopsin mediated signaling pathway (GO:0022400)18.0191874
175* rhodopsin mediated signaling pathway (GO:0016056)17.5977114
176retinal cone cell development (GO:0046549)14.5972225
177photoreceptor cell development (GO:0042461)13.1340553
178photoreceptor cell maintenance (GO:0045494)12.6405313
179eye photoreceptor cell development (GO:0042462)12.5219403
180detection of light stimulus involved in sensory perception (GO:0050962)10.8509991
181detection of light stimulus involved in visual perception (GO:0050908)10.8509991
182retinal rod cell development (GO:0046548)10.5013839
183* phototransduction (GO:0007602)10.3971997
184* phototransduction, visible light (GO:0007603)10.1774191
185positive regulation of guanylate cyclase activity (GO:0031284)10.0105076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.04056310
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.66541568
3ZNF274_21170338_ChIP-Seq_K562_Hela3.51571532
4EZH2_22144423_ChIP-Seq_EOC_Human3.35778950
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.22979045
6DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.92827902
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.77573731
8VDR_22108803_ChIP-Seq_LS180_Human2.62356649
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56579974
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48643018
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47966629
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.36930839
13DROSHA_22980978_ChIP-Seq_HELA_Human2.27780123
14GBX2_23144817_ChIP-Seq_PC3_Human2.20504257
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03965934
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00908615
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93261820
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.93147243
19FUS_26573619_Chip-Seq_HEK293_Human1.91872412
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89412284
21TAF15_26573619_Chip-Seq_HEK293_Human1.83985658
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81231991
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81124752
24SMAD3_21741376_ChIP-Seq_HESCs_Human1.79275487
25* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.79047665
26KDM2B_26808549_Chip-Seq_K562_Human1.78142557
27* EWS_26573619_Chip-Seq_HEK293_Human1.74935234
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.71826549
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67072739
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65454335
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.64071244
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63374292
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58501240
34AR_19668381_ChIP-Seq_PC3_Human1.56663299
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56525166
36ER_23166858_ChIP-Seq_MCF-7_Human1.55480712
37AR_21572438_ChIP-Seq_LNCaP_Human1.55005126
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54578012
39REST_21632747_ChIP-Seq_MESCs_Mouse1.53104467
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51259047
41TCF4_18268006_ChIP-ChIP_LS174T_Human1.50398812
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49150475
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48759143
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48590995
45NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.46531070
46P53_22127205_ChIP-Seq_FIBROBLAST_Human1.46417952
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46359091
48* EZH2_27294783_Chip-Seq_ESCs_Mouse1.46145139
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46053055
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45998044
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44944223
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44732507
53* CBX2_27304074_Chip-Seq_ESCs_Mouse1.43809782
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43756870
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42881190
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.41715902
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.41657918
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39513968
59AR_25329375_ChIP-Seq_VCAP_Human1.39445706
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.39018314
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38883083
62ELK4_26923725_Chip-Seq_MESODERM_Mouse1.38539079
63IRF1_19129219_ChIP-ChIP_H3396_Human1.38527119
64TP53_22573176_ChIP-Seq_HFKS_Human1.37615454
65CTCF_27219007_Chip-Seq_Bcells_Human1.36520535
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.35932700
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.35748689
68RNF2_27304074_Chip-Seq_NSC_Mouse1.35145889
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34986291
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34223623
71SOX2_19829295_ChIP-Seq_ESCs_Human1.34058750
72NANOG_19829295_ChIP-Seq_ESCs_Human1.34058750
73* SMC4_20622854_ChIP-Seq_HELA_Human1.31911645
74TCF4_23295773_ChIP-Seq_U87_Human1.31818322
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29909352
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.29909352
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.29734816
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.27946815
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.27941110
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26757262
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26757262
82EZH2_18974828_ChIP-Seq_MESCs_Mouse1.26431510
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.26431510
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25946754
85MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25893559
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.25327335
87P68_20966046_ChIP-Seq_HELA_Human1.25056089
88TBL1_22424771_ChIP-Seq_293T_Human1.25030273
89ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23833953
90CTCF_20526341_ChIP-Seq_ESCs_Human1.23486632
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23464049
92* RING1B_27294783_Chip-Seq_NPCs_Mouse1.23399469
93SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22595531
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22470723
95TCF4_22108803_ChIP-Seq_LS180_Human1.21755701
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21556384
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21536755
98CREB1_26743006_Chip-Seq_LNCaP_Human1.20705548
99KDM2B_26808549_Chip-Seq_JURKAT_Human1.20377052
100SMAD4_21799915_ChIP-Seq_A2780_Human1.20001722
101JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19960195
102JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19847664
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17222587
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16965395
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16142830
106NCOR_22424771_ChIP-Seq_293T_Human1.15788323
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15688799
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.15252652
109* RUNX2_22187159_ChIP-Seq_PCA_Human1.15092015
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14700977
111* TAF2_19829295_ChIP-Seq_ESCs_Human1.14222787
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13808167
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13020642
114MYC_18940864_ChIP-ChIP_HL60_Human1.12452084
115NFE2_27457419_Chip-Seq_LIVER_Mouse1.12117075
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10990244
117GATA3_21878914_ChIP-Seq_MCF-7_Human1.10149733
118WDR5_24793694_ChIP-Seq_LNCAP_Human1.10111631
119EGR1_19032775_ChIP-ChIP_M12_Human1.09349612
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.09093586
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08821866
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.08343232
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07892880
124AR_20517297_ChIP-Seq_VCAP_Human1.07818413
125BCAT_22108803_ChIP-Seq_LS180_Human1.07675979
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07472756
127P53_22387025_ChIP-Seq_ESCs_Mouse1.07414487
128CBP_21632823_ChIP-Seq_H3396_Human1.07189428
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06922348
130IGF1R_20145208_ChIP-Seq_DFB_Human1.06662298
131FLI1_21867929_ChIP-Seq_TH2_Mouse1.06524706
132STAT3_23295773_ChIP-Seq_U87_Human1.06441226
133* EZH2_27304074_Chip-Seq_ESCs_Mouse1.05779900
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05614766
135KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.05183205
136HTT_18923047_ChIP-ChIP_STHdh_Human1.04438122
137ISL1_27105846_Chip-Seq_CPCs_Mouse1.03751490
138SMAD4_21741376_ChIP-Seq_EPCs_Human1.03465376
139PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03312192
140POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03154542
141OCT1_27270436_Chip-Seq_PROSTATE_Human1.02730743
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02642884
143FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02048526
144SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00050533
145SA1_27219007_Chip-Seq_Bcells_Human0.99700865
146DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99618643
147* RNF2_27304074_Chip-Seq_ESCs_Mouse0.99371420
148TAL1_26923725_Chip-Seq_HPCs_Mouse0.99206856
149OCT4_19829295_ChIP-Seq_ESCs_Human0.99098953
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.98040306
151DPY_21335234_ChIP-Seq_ESCs_Mouse0.97862800
152P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.96689648
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.95125734
154EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94745936
155GF1_26923725_Chip-Seq_HPCs_Mouse0.92777336
156GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92536975
157RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92393257
158CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91142437
159YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88881258
160ERG_20517297_ChIP-Seq_VCAP_Human0.88665102
161* GATA1_19941827_ChIP-Seq_MEL_Mouse0.86957218
162DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86794569
163VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86551964
164* SMAD4_21741376_ChIP-Seq_ESCs_Human0.86347041
165LXR_22292898_ChIP-Seq_THP-1_Human0.85975878
166LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85810365
167IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84762047
168CBP_20019798_ChIP-Seq_JUKART_Human0.84762047
169* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84336144
170SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.84290447
171RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84001186
172P300_19829295_ChIP-Seq_ESCs_Human0.83908473
173SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83317601
174CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83170289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.82104628
2MP0005253_abnormal_eye_physiology7.04247580
3MP0006072_abnormal_retinal_apoptosis6.79519044
4MP0003950_abnormal_plasma_membrane4.55764325
5* MP0005195_abnormal_posterior_eye3.95306008
6MP0001324_abnormal_eye_pigmentation3.69718213
7MP0005391_vision/eye_phenotype3.44290262
8MP0003787_abnormal_imprinting3.28258044
9MP0002090_abnormal_vision2.79667519
10MP0008877_abnormal_DNA_methylation2.77000758
11MP0002837_dystrophic_cardiac_calcinosis2.64123500
12MP0005423_abnormal_somatic_nervous2.60459190
13* MP0002229_neurodegeneration2.50965362
14MP0005645_abnormal_hypothalamus_physiol2.43718558
15MP0001764_abnormal_homeostasis2.38009100
16MP0003195_calcinosis2.15611141
17MP0001986_abnormal_taste_sensitivity2.04631882
18MP0005646_abnormal_pituitary_gland2.04205555
19MP0003011_delayed_dark_adaptation10.8163168
20* MP0002752_abnormal_somatic_nervous1.92022967
21MP0002736_abnormal_nociception_after1.75065681
22MP0008872_abnormal_physiological_respon1.65484498
23MP0003122_maternal_imprinting1.63509423
24MP0003283_abnormal_digestive_organ1.61220143
25MP0002653_abnormal_ependyma_morphology1.58170073
26MP0000569_abnormal_digit_pigmentation1.50620100
27MP0003121_genomic_imprinting1.49751067
28MP0005075_abnormal_melanosome_morpholog1.49632178
29MP0004133_heterotaxia1.47462454
30MP0002938_white_spotting1.46334651
31MP0008875_abnormal_xenobiotic_pharmacok1.46111558
32MP0005379_endocrine/exocrine_gland_phen1.45687367
33MP0003136_yellow_coat_color1.44839049
34MP0002876_abnormal_thyroid_physiology1.43977022
35MP0001970_abnormal_pain_threshold1.42281484
36MP0002163_abnormal_gland_morphology1.40658608
37MP0001485_abnormal_pinna_reflex1.40520835
38* MP0002882_abnormal_neuron_morphology1.39674943
39MP0002557_abnormal_social/conspecific_i1.35507423
40MP0002735_abnormal_chemical_nociception1.34734821
41MP0005084_abnormal_gallbladder_morpholo1.33812476
42MP0001501_abnormal_sleep_pattern1.33166638
43MP0002733_abnormal_thermal_nociception1.31781182
44MP0002138_abnormal_hepatobiliary_system1.30050298
45MP0006276_abnormal_autonomic_nervous1.23570579
46MP0004019_abnormal_vitamin_homeostasis1.23169830
47MP0001502_abnormal_circadian_rhythm1.21884436
48MP0004885_abnormal_endolymph1.16216878
49MP0004233_abnormal_muscle_weight1.14097288
50MP0004147_increased_porphyrin_level1.12698121
51MP0000372_irregular_coat_pigmentation1.11372120
52MP0005197_abnormal_uvea_morphology1.09864205
53MP0005174_abnormal_tail_pigmentation1.06348216
54MP0001984_abnormal_olfaction1.06142120
55MP0008995_early_reproductive_senescence1.04904023
56MP0005187_abnormal_penis_morphology1.03078883
57MP0005671_abnormal_response_to1.02992838
58MP0005389_reproductive_system_phenotype1.00095206
59MP0000427_abnormal_hair_cycle0.99930515
60MP0002909_abnormal_adrenal_gland0.99171167
61MP0002160_abnormal_reproductive_system0.97879838
62MP0002822_catalepsy0.92500123
63MP0001919_abnormal_reproductive_system0.90817807
64MP0000566_synostosis0.90341093
65MP0005394_taste/olfaction_phenotype0.89884278
66MP0005499_abnormal_olfactory_system0.89884278
67MP0001944_abnormal_pancreas_morphology0.89367874
68MP0002234_abnormal_pharynx_morphology0.88392325
69MP0002693_abnormal_pancreas_physiology0.87479107
70MP0002127_abnormal_cardiovascular_syste0.84215661
71MP0004270_analgesia0.83549092
72MP0000955_abnormal_spinal_cord0.82577324
73MP0002332_abnormal_exercise_endurance0.82145472
74MP0002277_abnormal_respiratory_mucosa0.82133617
75MP0006292_abnormal_olfactory_placode0.81335541
76MP0005377_hearing/vestibular/ear_phenot0.80131818
77MP0003878_abnormal_ear_physiology0.80131818
78MP0008789_abnormal_olfactory_epithelium0.76334787
79MP0001440_abnormal_grooming_behavior0.75531978
80MP0002751_abnormal_autonomic_nervous0.75484043
81MP0000383_abnormal_hair_follicle0.74341288
82MP0005220_abnormal_exocrine_pancreas0.74259693
83MP0002272_abnormal_nervous_system0.73158102
84MP0002095_abnormal_skin_pigmentation0.72909092
85MP0001486_abnormal_startle_reflex0.69648273
86* MP0003634_abnormal_glial_cell0.67220923
87MP0001286_abnormal_eye_development0.59342111
88MP0003880_abnormal_central_pattern0.58886256
89MP0004859_abnormal_synaptic_plasticity0.54955246
90MP0005376_homeostasis/metabolism_phenot0.54533456
91MP0009046_muscle_twitch0.53708899
92MP0002734_abnormal_mechanical_nocicepti0.53206878
93MP0002064_seizures0.52722968
94MP0001963_abnormal_hearing_physiology0.52012536
95MP0003635_abnormal_synaptic_transmissio0.47514281
96MP0002067_abnormal_sensory_capabilities0.40851215
97MP0004782_abnormal_surfactant_physiolog0.40713263
98MP0004215_abnormal_myocardial_fiber0.38387253
99MP0002063_abnormal_learning/memory/cond0.38195337
100MP0005076_abnormal_cell_differentiation0.37183404
101MP0005248_abnormal_Harderian_gland0.36003865
102MP0003045_fibrosis0.34178732
103MP0002697_abnormal_eye_size0.33602308
104MP0004043_abnormal_pH_regulation0.33338221
105MP0002572_abnormal_emotion/affect_behav0.32996306
106MP0000465_gastrointestinal_hemorrhage0.32366654
107MP0000026_abnormal_inner_ear0.31509243
108MP0004085_abnormal_heartbeat0.31253344
109MP0004924_abnormal_behavior0.30550436
110MP0005386_behavior/neurological_phenoty0.30550436
111MP0009745_abnormal_behavioral_response0.29911670
112MP0004145_abnormal_muscle_electrophysio0.29743732
113MP0005193_abnormal_anterior_eye0.28098733
114MP0005620_abnormal_muscle_contractility0.27024769
115MP0009780_abnormal_chondrocyte_physiolo0.26982641
116MP0003252_abnormal_bile_duct0.26277229
117MP0000631_abnormal_neuroendocrine_gland0.26165921
118MP0005595_abnormal_vascular_smooth0.25543949
119MP0008569_lethality_at_weaning0.24803981
120MP0002928_abnormal_bile_duct0.24437481
121MP0003890_abnormal_embryonic-extraembry0.24161648
122MP0003632_abnormal_nervous_system0.23721228
123MP0001915_intracranial_hemorrhage0.23427510
124MP0010030_abnormal_orbit_morphology0.23359260
125MP0002152_abnormal_brain_morphology0.22961879
126MP0001968_abnormal_touch/_nociception0.22310232
127MP0002184_abnormal_innervation0.22149339
128MP0004811_abnormal_neuron_physiology0.21912556
129MP0002066_abnormal_motor_capabilities/c0.21808243
130MP0004142_abnormal_muscle_tone0.19593857
131MP0004742_abnormal_vestibular_system0.19488902
132* MP0002638_abnormal_pupillary_reflex0.18836184
133MP0000751_myopathy0.17612645
134MP0003633_abnormal_nervous_system0.17169692
135MP0003646_muscle_fatigue0.17101428
136MP0002102_abnormal_ear_morphology0.16188396
137MP0003943_abnormal_hepatobiliary_system0.15924508
138MP0010386_abnormal_urinary_bladder0.15600686
139MP0003638_abnormal_response/metabolism_0.14790608
140MP0001661_extended_life_span0.14707169
141MP0003631_nervous_system_phenotype0.13886757
142MP0002108_abnormal_muscle_morphology0.13882619
143MP0003329_amyloid_beta_deposits0.13376060
144MP0004036_abnormal_muscle_relaxation0.12988686
145MP0008961_abnormal_basal_metabolism0.12332706
146MP0001905_abnormal_dopamine_level0.12215949
147MP0000778_abnormal_nervous_system0.11837488
148MP0008004_abnormal_stomach_pH0.11093587
149MP0000647_abnormal_sebaceous_gland0.10662481
150MP0005330_cardiomyopathy0.10403737
151MP0005266_abnormal_metabolism0.10087167
152MP0008775_abnormal_heart_ventricle0.09628064
153MP0001177_atelectasis0.09525865

Predicted human phenotypes

RankGene SetZ-score
1Chorioretinal atrophy (HP:0000533)9.97799302
2Pigmentary retinal degeneration (HP:0001146)9.58262219
3* Abnormal rod and cone electroretinograms (HP:0008323)9.37508122
4Pendular nystagmus (HP:0012043)8.44859118
5Central scotoma (HP:0000603)8.23414690
6Attenuation of retinal blood vessels (HP:0007843)8.01714081
7Scotoma (HP:0000575)7.37821847
8Abolished electroretinogram (ERG) (HP:0000550)7.18723417
9Abnormality of macular pigmentation (HP:0008002)7.18246166
10Dyschromatopsia (HP:0007641)6.92299378
11Decreased central vision (HP:0007663)6.41426539
12* Type II diabetes mellitus (HP:0005978)5.69801672
13Keratoconus (HP:0000563)5.51977956
14Increased corneal curvature (HP:0100692)5.51977956
15* Photophobia (HP:0000613)5.50854348
16Vitreoretinal degeneration (HP:0000655)5.14305048
17Macular degeneration (HP:0000608)5.12510035
18Cone-rod dystrophy (HP:0000548)5.09649498
19Severe visual impairment (HP:0001141)4.94024740
20Constricted visual fields (HP:0001133)4.44185509
21Posterior subcapsular cataract (HP:0007787)4.40491675
22* Retinitis pigmentosa (HP:0000510)4.38905498
23Choroideremia (HP:0001139)4.33530734
24Decreased electroretinogram (ERG) amplitude (HP:0000654)3.61728260
25Nephronophthisis (HP:0000090)3.52290707
26Progressive visual loss (HP:0000529)3.24407019
27Abnormality of the renal medulla (HP:0100957)3.10060401
28Abnormality of the renal cortex (HP:0011035)2.97844107
29Retinal atrophy (HP:0001105)2.93576383
30Focal motor seizures (HP:0011153)2.88286020
31Polydipsia (HP:0001959)2.85359407
32Abnormal drinking behavior (HP:0030082)2.85359407
33Congenital, generalized hypertrichosis (HP:0004540)2.81396743
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.77647121
35Absent/shortened dynein arms (HP:0200106)2.77647121
36Abnormal respiratory motile cilium morphology (HP:0005938)2.67666565
37Abnormal respiratory epithelium morphology (HP:0012253)2.67666565
38Acute necrotizing encephalopathy (HP:0006965)2.67191444
39Gait imbalance (HP:0002141)2.63499974
40Subcapsular cataract (HP:0000523)2.63013791
41Hemiparesis (HP:0001269)2.61814564
42Optic disc pallor (HP:0000543)2.61629978
43Abnormal ciliary motility (HP:0012262)2.60993204
44Congenital primary aphakia (HP:0007707)2.60829402
45Progressive macrocephaly (HP:0004481)2.56914283
46Mitochondrial inheritance (HP:0001427)2.56832010
47* Wide nasal bridge (HP:0000431)2.53450826
48Congenital sensorineural hearing impairment (HP:0008527)2.48299213
49Increased CSF lactate (HP:0002490)2.44773011
50Focal seizures (HP:0007359)2.41694587
51Type II lissencephaly (HP:0007260)2.37840398
52Acute encephalopathy (HP:0006846)2.35961247
53Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.35690323
54Abnormal respiratory motile cilium physiology (HP:0012261)2.33440527
55Polyuria (HP:0000103)2.32108691
56Nephrogenic diabetes insipidus (HP:0009806)2.31037151
57Abnormal biliary tract physiology (HP:0012439)2.30852367
58Bile duct proliferation (HP:0001408)2.30852367
59Hypothermia (HP:0002045)2.29413331
60Tubular atrophy (HP:0000092)2.28550725
61Abnormal mitochondria in muscle tissue (HP:0008316)2.24581832
62Dialeptic seizures (HP:0011146)2.21922236
63Medial flaring of the eyebrow (HP:0010747)2.21849241
64Renal cortical cysts (HP:0000803)2.21093137
65Large for gestational age (HP:0001520)2.19250867
66Male pseudohermaphroditism (HP:0000037)2.14375687
67Intestinal atresia (HP:0011100)2.13067626
68Hepatocellular necrosis (HP:0001404)2.08467421
69Hypomagnesemia (HP:0002917)2.07077725
70Aplasia/Hypoplasia of the spleen (HP:0010451)2.05941362
71Hepatic necrosis (HP:0002605)2.04159455
72Hyperventilation (HP:0002883)2.02775678
73Polyphagia (HP:0002591)2.01340066
74Ketoacidosis (HP:0001993)2.00514014
75* Congenital stationary night blindness (HP:0007642)13.6422697
76Bony spicule pigmentary retinopathy (HP:0007737)12.3572278
77Absent rod-and cone-mediated responses on ERG (HP:0007688)10.9757605
78Poor coordination (HP:0002370)1.99153214
79Asplenia (HP:0001746)1.98920242
80Methylmalonic acidemia (HP:0002912)1.98331275
813-Methylglutaconic aciduria (HP:0003535)1.94843172
82Lipid accumulation in hepatocytes (HP:0006561)1.94702055
83Optic nerve hypoplasia (HP:0000609)1.93940009
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93740899
85Thyroiditis (HP:0100646)1.91043563
86Rhinitis (HP:0012384)1.90218247
87Abnormality of the labia minora (HP:0012880)1.89974159
88Severe muscular hypotonia (HP:0006829)1.85242569
89Increased hepatocellular lipid droplets (HP:0006565)1.83417041
90Inability to walk (HP:0002540)1.83053380
91Gaze-evoked nystagmus (HP:0000640)1.81259366
92Abnormal urine output (HP:0012590)1.80413249
93Limb dystonia (HP:0002451)1.79846851
94Methylmalonic aciduria (HP:0012120)1.79808627
95Vaginal atresia (HP:0000148)1.79804338
96Pachygyria (HP:0001302)1.79268211
97Lissencephaly (HP:0001339)1.78795335
98Ketosis (HP:0001946)1.78236853
99Tachypnea (HP:0002789)1.77765885
100Broad-based gait (HP:0002136)1.73233949
101Absence seizures (HP:0002121)1.73143232
102Genital tract atresia (HP:0001827)1.72927705
103Interstitial pulmonary disease (HP:0006530)1.65981627
104* Optic atrophy (HP:0000648)1.64952949
105True hermaphroditism (HP:0010459)1.62418871
106Pancreatic fibrosis (HP:0100732)1.51107787
107Aplasia/Hypoplasia of the lens (HP:0008063)1.48243734
108Horizontal nystagmus (HP:0000666)1.45360824
109Polar cataract (HP:0010696)1.43978700
110Severe Myopia (HP:0011003)1.36484368
111Dysdiadochokinesis (HP:0002075)1.35142359
112Cystic liver disease (HP:0006706)1.26029408
113Abnormality of the fovea (HP:0000493)1.25018215
114Pancreatic cysts (HP:0001737)1.21164937
115Aplasia/Hypoplasia of the fovea (HP:0008060)1.19074861
116Hypoplasia of the fovea (HP:0007750)1.19074861
117Astigmatism (HP:0000483)1.17941746
118Retinal detachment (HP:0000541)1.11250300
119Cerebellar dysplasia (HP:0007033)1.09960594
120Aplasia/Hypoplasia of the tongue (HP:0010295)1.08411557
121Epileptic encephalopathy (HP:0200134)1.08130231
122Specific learning disability (HP:0001328)1.07588571
123Broad foot (HP:0001769)1.07408952
124Left ventricular hypertrophy (HP:0001712)1.05650972
125Decreased testicular size (HP:0008734)1.01975790
126Asthma (HP:0002099)0.97814312
127Recurrent sinusitis (HP:0011108)0.95602717
128Sclerocornea (HP:0000647)0.94670586
129Chorioretinal coloboma (HP:0000567)0.93537283
130Aplasia/Hypoplasia of the macula (HP:0008059)0.92374785
131Visual hallucinations (HP:0002367)0.91545967
132Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.91289933
133Hypermetropia (HP:0000540)0.89544959
134Truncal ataxia (HP:0002078)0.89278083
135Furrowed tongue (HP:0000221)0.89023381
136Progressive cerebellar ataxia (HP:0002073)0.86733750
137Aplasia/Hypoplasia affecting the retina (HP:0008061)0.84848620
138Febrile seizures (HP:0002373)0.83248716
139Partial agenesis of the corpus callosum (HP:0001338)0.83093792
140Molar tooth sign on MRI (HP:0002419)0.82151276
141Abnormality of midbrain morphology (HP:0002418)0.82151276
142Abnormality of dental color (HP:0011073)0.79477395
143Anencephaly (HP:0002323)0.74879018
144Dental crowding (HP:0000678)0.73769998
145Hypodontia (HP:0000668)0.72762072
146Postaxial hand polydactyly (HP:0001162)0.72335732
147Short foot (HP:0001773)0.69527356
148Congenital hepatic fibrosis (HP:0002612)0.66665313
149Genetic anticipation (HP:0003743)0.66100628
150Abnormality of the lower motor neuron (HP:0002366)0.64959339
151Lymphopenia (HP:0001888)0.63558538
152Prolonged QT interval (HP:0001657)0.63284539
153Generalized myoclonic seizures (HP:0002123)0.61936222
154Hirsutism (HP:0001007)0.60963098
155Heterotopia (HP:0002282)0.60634829
156Postaxial foot polydactyly (HP:0001830)0.58746218
157Nephrotic syndrome (HP:0000100)0.58618028
158Chronic hepatic failure (HP:0100626)0.58430324
159Prominent nasal bridge (HP:0000426)0.57392605
160Abnormality of the parathyroid morphology (HP:0011766)0.57336587
161Abnormality of cells of the lymphoid lineage (HP:0012140)0.57217049
162Polycystic ovaries (HP:0000147)0.57104280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK8.24196505
2PINK13.04516583
3IRAK23.02547241
4ADRBK22.94073694
5BMPR1B2.79551595
6MAP4K22.73359187
7WNK32.71243162
8CASK2.58107849
9NUAK12.17906988
10ZAK2.02485777
11GRK110.3534752
12TXK1.96416240
13MAPK131.89972758
14MAP3K101.87068457
15MAPK151.75723690
16SIK21.74833803
17ACVR1B1.70437456
18WNK41.69749867
19OXSR11.60313228
20TLK11.57233874
21TAOK31.56852524
22FGFR21.54669749
23TNIK1.48748638
24DAPK21.48080074
25ADRBK11.44006573
26DYRK21.43942209
27STK391.41718669
28VRK11.32878345
29CAMK1G1.32023813
30MAPK71.29764569
31MAPK121.27909496
32VRK21.26282454
33EPHA41.25501642
34SGK2231.25490037
35SGK4941.25490037
36BRD41.25270895
37PRKD31.23850008
38RPS6KA41.21859787
39INSRR1.18582382
40MARK11.17983603
41PAK61.16478923
42CDK121.09774235
43HIPK21.09530514
44STK381.08825195
45ICK1.08734824
46NEK11.07515336
47CAMK1D1.04576023
48MAP3K41.03617194
49PRKCZ1.02253757
50CCNB11.01553651
51CAMKK21.01551516
52STK161.00373497
53TIE11.00141778
54PRKCH0.99803550
55CSNK1D0.98912383
56PNCK0.96589521
57TAF10.96407985
58PASK0.96398234
59SGK20.94389562
60PRKCE0.94014286
61BCKDK0.91477493
62ERBB20.90663084
63NLK0.87738382
64DYRK1A0.87673447
65TGFBR10.86538372
66MAP4K10.85676871
67CAMKK10.84067644
68MAPKAPK30.83912765
69AKT30.83107135
70SGK30.82925844
71CSNK1G10.80273688
72CSNK1G20.80260429
73TEC0.80084483
74PRKAA10.78713195
75KIT0.76514457
76CDK190.76217065
77PRKCQ0.75873730
78MAPKAPK50.72337646
79MST40.69994371
80PRKCI0.69058439
81ERBB30.68924777
82PRKCB0.67778984
83CSNK1G30.66946279
84WNK10.66843470
85IRAK10.66439069
86MAP2K60.66260990
87CAMK2D0.65848353
88GRK50.65814839
89ITK0.65735409
90PRKACG0.64674129
91IKBKB0.63325771
92FES0.61873189
93NEK20.61135709
94DYRK1B0.60916499
95CDK30.60632355
96PHKG20.60302948
97PHKG10.60302948
98NEK60.59043152
99RPS6KA30.58953849
100PLK20.57926616
101PTK2B0.56376502
102PRKAA20.56291635
103NME10.55787343
104SCYL20.55246380
105SYK0.50647303
106RPS6KA50.50580744
107MKNK20.48268816
108PRKD20.47485423
109SIK10.47450217
110CSNK1A10.46790845
111SGK10.46241721
112GSK3B0.46060611
113MARK30.46008896
114TTK0.46006559
115PDK20.44911454
116PLK30.44767195
117MAPK90.44632737
118MKNK10.43802061
119PRKDC0.43665199
120CAMK10.43090339
121PRKG10.42812475
122IRAK40.42220036
123MAPK140.42094882
124CDK50.41943315
125CAMK2A0.41187935
126STK38L0.40703739
127MAPK100.40652905
128PRKCG0.38680297
129CSNK1A1L0.36318922
130CAMK40.35949914
131CDK90.35946801
132MINK10.35499120
133LATS10.35395370
134CDK10.34998297
135MAP2K70.34504447
136PIK3CA0.34406258
137STK110.33860437
138FLT30.33658565
139MAP3K70.32753619
140AKT20.31880911
141STK30.31615898
142UHMK10.31340140
143PRKACA0.30525154
144MAP2K40.27446973
145PKN10.27031028
146PRKCA0.26716471
147FRK0.25844796
148CSNK1E0.24566248
149ALK0.24176243
150MAPK80.23902758
151CHEK10.22935450
152RPS6KB10.22919125
153PRPF4B0.22806876
154PAK30.22671608
155MYLK0.21412997
156CDC42BPA0.20730813
157ATM0.20426449
158NTRK20.20243831
159MAPK30.20040584
160NTRK30.19377461
161TNK20.18264578
162PDGFRB0.18038006

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.80836964
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.43369315
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.34558390
4Butanoate metabolism_Homo sapiens_hsa006502.14227264
5Parkinsons disease_Homo sapiens_hsa050122.08545828
6* Phototransduction_Homo sapiens_hsa0474415.8422861
7Protein export_Homo sapiens_hsa030601.98180332
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93748044
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.84623686
10Synaptic vesicle cycle_Homo sapiens_hsa047211.72937665
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61886198
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55635079
13Ether lipid metabolism_Homo sapiens_hsa005651.54955278
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54285208
15Regulation of autophagy_Homo sapiens_hsa041401.51847755
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.50298410
17Olfactory transduction_Homo sapiens_hsa047401.49799507
18Selenocompound metabolism_Homo sapiens_hsa004501.48919454
19Tryptophan metabolism_Homo sapiens_hsa003801.43701656
20Peroxisome_Homo sapiens_hsa041461.43420486
21Taste transduction_Homo sapiens_hsa047421.42039682
22Type I diabetes mellitus_Homo sapiens_hsa049401.41349907
23Homologous recombination_Homo sapiens_hsa034401.41067161
24Basal transcription factors_Homo sapiens_hsa030221.39701824
25Fanconi anemia pathway_Homo sapiens_hsa034601.37889613
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34952467
27Alzheimers disease_Homo sapiens_hsa050101.34533884
28Huntingtons disease_Homo sapiens_hsa050161.33049310
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32130387
30GABAergic synapse_Homo sapiens_hsa047271.31019117
31RNA polymerase_Homo sapiens_hsa030201.28970205
32Propanoate metabolism_Homo sapiens_hsa006401.15279879
33Asthma_Homo sapiens_hsa053101.11590007
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10141512
35Primary immunodeficiency_Homo sapiens_hsa053401.09513459
36Chemical carcinogenesis_Homo sapiens_hsa052041.07256847
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03700549
38RNA degradation_Homo sapiens_hsa030181.01946515
39Cholinergic synapse_Homo sapiens_hsa047250.99250101
40Primary bile acid biosynthesis_Homo sapiens_hsa001200.97191542
41Proteasome_Homo sapiens_hsa030500.94772900
42Retinol metabolism_Homo sapiens_hsa008300.94691746
43Arachidonic acid metabolism_Homo sapiens_hsa005900.94086304
44Circadian rhythm_Homo sapiens_hsa047100.93636825
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93106826
46Ovarian steroidogenesis_Homo sapiens_hsa049130.89434550
47Circadian entrainment_Homo sapiens_hsa047130.89377336
48Morphine addiction_Homo sapiens_hsa050320.89131664
49Ribosome_Homo sapiens_hsa030100.88683555
50Graft-versus-host disease_Homo sapiens_hsa053320.88499498
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.86229730
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84106972
53Allograft rejection_Homo sapiens_hsa053300.83186090
54Glutamatergic synapse_Homo sapiens_hsa047240.83161994
55Dopaminergic synapse_Homo sapiens_hsa047280.82945672
56Nitrogen metabolism_Homo sapiens_hsa009100.79808744
57Autoimmune thyroid disease_Homo sapiens_hsa053200.77489562
58beta-Alanine metabolism_Homo sapiens_hsa004100.76131866
59One carbon pool by folate_Homo sapiens_hsa006700.70372665
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70056283
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68956700
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68934972
63Sulfur metabolism_Homo sapiens_hsa009200.68641232
64Serotonergic synapse_Homo sapiens_hsa047260.67528914
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66577074
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64865978
67ABC transporters_Homo sapiens_hsa020100.64338538
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62018087
69Rheumatoid arthritis_Homo sapiens_hsa053230.61991334
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61359846
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60124150
72Metabolic pathways_Homo sapiens_hsa011000.58466426
73Insulin secretion_Homo sapiens_hsa049110.57668815
74Dorso-ventral axis formation_Homo sapiens_hsa043200.54354906
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53154282
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49917051
77Fructose and mannose metabolism_Homo sapiens_hsa000510.48645156
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48244826
79Histidine metabolism_Homo sapiens_hsa003400.46719464
80Nicotine addiction_Homo sapiens_hsa050330.46509313
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44865507
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44024235
83Oxytocin signaling pathway_Homo sapiens_hsa049210.43433165
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43048892
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42199843
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40879748
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39290888
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38722360
89Hedgehog signaling pathway_Homo sapiens_hsa043400.38592903
90Non-homologous end-joining_Homo sapiens_hsa034500.38133098
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37757283
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36285826
93Arginine biosynthesis_Homo sapiens_hsa002200.34342310
94cAMP signaling pathway_Homo sapiens_hsa040240.34048308
95Dilated cardiomyopathy_Homo sapiens_hsa054140.33477976
96Inositol phosphate metabolism_Homo sapiens_hsa005620.33444425
97Glycerolipid metabolism_Homo sapiens_hsa005610.33340862
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32535883
99Renin secretion_Homo sapiens_hsa049240.32131032
100mTOR signaling pathway_Homo sapiens_hsa041500.32101641
101Cardiac muscle contraction_Homo sapiens_hsa042600.31422791
102Fatty acid elongation_Homo sapiens_hsa000620.30787120
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30475369
104Salivary secretion_Homo sapiens_hsa049700.29865642
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.29860146
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28848995
107Caffeine metabolism_Homo sapiens_hsa002320.28841810
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28333196
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27718023
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.27394830
111Biosynthesis of amino acids_Homo sapiens_hsa012300.26316412
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.25492117
113Type II diabetes mellitus_Homo sapiens_hsa049300.25388577
114Gastric acid secretion_Homo sapiens_hsa049710.24691676
115Alcoholism_Homo sapiens_hsa050340.24021330
116Glucagon signaling pathway_Homo sapiens_hsa049220.23123655
117Galactose metabolism_Homo sapiens_hsa000520.23111072
118Lysine degradation_Homo sapiens_hsa003100.22575341
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22485236
120Chemokine signaling pathway_Homo sapiens_hsa040620.21583823
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.21438005
122Cocaine addiction_Homo sapiens_hsa050300.21097629
123Long-term potentiation_Homo sapiens_hsa047200.21091888
124HIF-1 signaling pathway_Homo sapiens_hsa040660.20934626
125Bile secretion_Homo sapiens_hsa049760.18277157
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17943726
127AMPK signaling pathway_Homo sapiens_hsa041520.17678313
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15786314
129* Purine metabolism_Homo sapiens_hsa002300.15273680
130Amphetamine addiction_Homo sapiens_hsa050310.14148231
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.13628667
132Ras signaling pathway_Homo sapiens_hsa040140.13502670
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12255591
134GnRH signaling pathway_Homo sapiens_hsa049120.12169489
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.12064061
136Pancreatic secretion_Homo sapiens_hsa049720.11129918
137mRNA surveillance pathway_Homo sapiens_hsa030150.10751014
138Mineral absorption_Homo sapiens_hsa049780.10578523
139Calcium signaling pathway_Homo sapiens_hsa040200.10131763
140Thyroid hormone synthesis_Homo sapiens_hsa049180.08602426
141Tight junction_Homo sapiens_hsa045300.08591209
142Insulin resistance_Homo sapiens_hsa049310.08095978
143Fat digestion and absorption_Homo sapiens_hsa049750.07963903
144Collecting duct acid secretion_Homo sapiens_hsa049660.07070853
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.06268511
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.06206027
147MAPK signaling pathway_Homo sapiens_hsa040100.05773558
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05450510
1492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.05069246
150Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.04886577
151Hippo signaling pathway_Homo sapiens_hsa043900.04535822
152Linoleic acid metabolism_Homo sapiens_hsa005910.04409539
153Renal cell carcinoma_Homo sapiens_hsa052110.04390455
154Glioma_Homo sapiens_hsa052140.03236087
155Choline metabolism in cancer_Homo sapiens_hsa052310.02704781
156Carbon metabolism_Homo sapiens_hsa012000.02321361
157Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.02022236
158Cysteine and methionine metabolism_Homo sapiens_hsa002700.01420243
159PI3K-Akt signaling pathway_Homo sapiens_hsa041510.00978887
160Vibrio cholerae infection_Homo sapiens_hsa051100.00709362
161Endocytosis_Homo sapiens_hsa041440.00483078
162Notch signaling pathway_Homo sapiens_hsa043300.00457317

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