PDE6D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein polyglutamylation (GO:0018095)6.48106097
2sensory perception of chemical stimulus (GO:0007606)6.33162570
3protein insertion into membrane (GO:0051205)5.87347306
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.31556021
5regulation of female gonad development (GO:2000194)5.26981074
6DNA deamination (GO:0045006)4.91548882
7microtubule severing (GO:0051013)4.80307529
8ATP synthesis coupled proton transport (GO:0015986)4.73464296
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.73464296
10proteasome assembly (GO:0043248)4.66328803
11regulation of cilium movement (GO:0003352)4.62528717
12central nervous system myelination (GO:0022010)4.61868878
13axon ensheathment in central nervous system (GO:0032291)4.61868878
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.54713940
15protein neddylation (GO:0045116)4.52106657
16protein localization to cilium (GO:0061512)4.49538916
17axonemal dynein complex assembly (GO:0070286)4.44368445
18intraciliary transport (GO:0042073)4.23085916
19respiratory electron transport chain (GO:0022904)4.20036161
20electron transport chain (GO:0022900)4.10451204
21protein complex biogenesis (GO:0070271)4.08258832
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.01722548
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.01722548
24platelet dense granule organization (GO:0060155)3.94802352
25axoneme assembly (GO:0035082)3.92815135
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.88145727
27adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.82839767
28regulation of cellular amino acid metabolic process (GO:0006521)3.78786958
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.75393947
30DNA damage response, detection of DNA damage (GO:0042769)3.73854227
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.72270168
32cilium morphogenesis (GO:0060271)3.66575059
33DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.64153059
34mitochondrial respiratory chain complex assembly (GO:0033108)3.62913618
35termination of RNA polymerase III transcription (GO:0006386)3.60778483
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.60778483
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.60356330
38cilium movement (GO:0003341)3.58995483
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.52558661
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.52278257
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.51712143
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.51712143
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.51712143
44intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.51284524
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.51284524
46positive regulation of mitochondrial fission (GO:0090141)3.50036089
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.49522140
48negative regulation of ligase activity (GO:0051352)3.49522140
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.48757516
50pyrimidine nucleobase catabolic process (GO:0006208)3.48320849
51respiratory chain complex IV assembly (GO:0008535)3.47530443
52rhodopsin mediated signaling pathway (GO:0016056)3.44021242
53chaperone-mediated protein transport (GO:0072321)3.43708996
54piRNA metabolic process (GO:0034587)3.42429682
55regulation of rhodopsin mediated signaling pathway (GO:0022400)3.41210981
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.40038332
57photoreceptor cell differentiation (GO:0046530)3.38789323
58eye photoreceptor cell differentiation (GO:0001754)3.38789323
59regulation of microtubule-based movement (GO:0060632)3.34189202
60negative regulation of microtubule polymerization (GO:0031115)3.33452962
61detection of light stimulus involved in sensory perception (GO:0050962)3.30612618
62detection of light stimulus involved in visual perception (GO:0050908)3.30612618
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30470168
64signal transduction involved in cell cycle checkpoint (GO:0072395)3.30260284
65establishment of viral latency (GO:0019043)3.29184026
66signal transduction involved in DNA integrity checkpoint (GO:0072401)3.28862689
67signal transduction involved in DNA damage checkpoint (GO:0072422)3.28862689
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.27134995
69negative regulation of cytosolic calcium ion concentration (GO:0051481)3.25874679
70photoreceptor cell maintenance (GO:0045494)3.25448913
71base-excision repair, AP site formation (GO:0006285)3.17711540
72deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.17081515
73single fertilization (GO:0007338)3.15645605
74neuron cell-cell adhesion (GO:0007158)3.14884018
75hydrogen ion transmembrane transport (GO:1902600)3.14727013
76negative regulation of telomere maintenance (GO:0032205)3.14541725
77multicellular organism reproduction (GO:0032504)3.14457651
78epithelial cilium movement (GO:0003351)3.06773448
79potassium ion export (GO:0071435)3.06451147
80regulation of mitochondrial translation (GO:0070129)3.06378232
81positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06170808
82regulation of voltage-gated calcium channel activity (GO:1901385)3.00789755
83energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.00248347
84ATP hydrolysis coupled proton transport (GO:0015991)3.00248347
85anterograde synaptic vesicle transport (GO:0048490)2.99550124
86cytochrome complex assembly (GO:0017004)2.98075298
87regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.96342111
88regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.96342111
89histone H2A acetylation (GO:0043968)2.96235931
90proton transport (GO:0015992)2.96024947
91deoxyribonucleotide catabolic process (GO:0009264)2.94812516
92protein targeting to mitochondrion (GO:0006626)2.94084185
93positive regulation of ligase activity (GO:0051351)2.93571402
94epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93456332
95hydrogen transport (GO:0006818)2.88223992
96GTP biosynthetic process (GO:0006183)2.86346382
97pyrimidine nucleotide catabolic process (GO:0006244)2.86272493
98pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.85455292
99acrosome reaction (GO:0007340)2.85285603
100purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.83665940
101mannosylation (GO:0097502)2.83430132
102regulation of cellular amine metabolic process (GO:0033238)2.83177955
103establishment of integrated proviral latency (GO:0075713)2.82952414
104cilium or flagellum-dependent cell motility (GO:0001539)2.82920251
105dopamine receptor signaling pathway (GO:0007212)2.82888349
106deoxyribose phosphate catabolic process (GO:0046386)2.80857579
107protein localization to mitochondrion (GO:0070585)2.80217644
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.79848855
109oxidative phosphorylation (GO:0006119)2.78539819
110establishment of protein localization to mitochondrion (GO:0072655)2.78071876
111preassembly of GPI anchor in ER membrane (GO:0016254)2.77814254
112negative regulation of inclusion body assembly (GO:0090084)2.77644354
113pseudouridine synthesis (GO:0001522)2.77257892
114microtubule bundle formation (GO:0001578)2.76565321
115magnesium ion transport (GO:0015693)2.76472597
116centriole replication (GO:0007099)2.76147078
117de novo posttranslational protein folding (GO:0051084)2.74135387
1182-deoxyribonucleotide metabolic process (GO:0009394)2.73782769
119RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73348054
120establishment of mitochondrion localization (GO:0051654)2.73150927
121negative regulation of cation channel activity (GO:2001258)2.72672025
122GMP metabolic process (GO:0046037)2.70977039
123histone H2B ubiquitination (GO:0033523)2.70751640
124DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.70033511
125fertilization (GO:0009566)2.69710541
126de novo protein folding (GO:0006458)2.69353956
127positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.68998716
128auditory receptor cell differentiation (GO:0042491)2.67848388
129protein deneddylation (GO:0000338)2.66552013
130synaptic vesicle exocytosis (GO:0016079)2.66155378
131purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.65690093
132regulation of ubiquitin-protein transferase activity (GO:0051438)2.65350798
133deoxyribose phosphate metabolic process (GO:0019692)2.65272248
134substrate-independent telencephalic tangential migration (GO:0021826)2.65084800
135substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.65084800
136purine nucleoside triphosphate biosynthetic process (GO:0009145)2.64640413
137DNA double-strand break processing (GO:0000729)2.64329670
138purine deoxyribonucleotide metabolic process (GO:0009151)2.64298843
139L-methionine salvage (GO:0071267)2.62347477
140L-methionine biosynthetic process (GO:0071265)2.62347477
141amino acid salvage (GO:0043102)2.62347477
142purine deoxyribonucleotide catabolic process (GO:0009155)2.59545295
143negative regulation of heart rate (GO:0010459)2.59408748
144ATP biosynthetic process (GO:0006754)2.59167054
145positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.59011719
146ensheathment of neurons (GO:0007272)2.58739919
147axon ensheathment (GO:0008366)2.58739919
148adenosine metabolic process (GO:0046085)2.58688873
149fusion of sperm to egg plasma membrane (GO:0007342)2.56861496
150myelination (GO:0042552)2.55771671
151GPI anchor biosynthetic process (GO:0006506)2.55269683
152reproduction (GO:0000003)2.55216809
153sequestering of actin monomers (GO:0042989)2.54380130
154establishment of melanosome localization (GO:0032401)2.53593320
155regulation of synapse structural plasticity (GO:0051823)2.52720528
156response to pheromone (GO:0019236)2.51695683
157negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.51120852
158substantia nigra development (GO:0021762)2.49972178
159microtubule-based transport (GO:0010970)2.49543059
160regulation of neurotransmitter uptake (GO:0051580)2.48405880
161pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.47647773
162behavioral response to cocaine (GO:0048148)2.43184600
163motile cilium assembly (GO:0044458)2.43043949
164negative regulation of calcium ion transmembrane transport (GO:1903170)2.41168598
165negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.41168598
166cellular response to glucagon stimulus (GO:0071377)2.41020823
167mitochondrial respiratory chain complex I assembly (GO:0032981)2.40211543
168NADH dehydrogenase complex assembly (GO:0010257)2.40211543
169mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.40211543
170melanosome transport (GO:0032402)2.39084874
171potassium ion homeostasis (GO:0055075)2.38987959
172nonmotile primary cilium assembly (GO:0035058)2.38733285
173establishment of pigment granule localization (GO:0051905)2.37562460
174cilium assembly (GO:0042384)2.37164889
175negative regulation of execution phase of apoptosis (GO:1900118)2.36345261
176neuronal action potential (GO:0019228)2.33684897
177cilium organization (GO:0044782)2.33357976
178cullin deneddylation (GO:0010388)2.32634847
179sperm-egg recognition (GO:0035036)2.31203437
180cellular potassium ion transport (GO:0071804)2.29626781
181potassium ion transmembrane transport (GO:0071805)2.29626781
182guanosine-containing compound biosynthetic process (GO:1901070)2.29116221
183iron-sulfur cluster assembly (GO:0016226)2.29031851
184metallo-sulfur cluster assembly (GO:0031163)2.29031851
185binding of sperm to zona pellucida (GO:0007339)2.28422008
186DNA methylation involved in gamete generation (GO:0043046)2.27846857
187adult walking behavior (GO:0007628)2.27706513
188regulation of synaptic vesicle exocytosis (GO:2000300)2.27057356
189detection of light stimulus (GO:0009583)2.25823952
190sensory perception of smell (GO:0007608)10.4897756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.62197098
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.65449412
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.15468049
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.91372838
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81897410
6* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.80190970
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.58839923
8ELK1_19687146_ChIP-ChIP_HELA_Human2.39962897
9ZNF274_21170338_ChIP-Seq_K562_Hela2.28727289
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17472906
11* FOXP3_21729870_ChIP-Seq_TREG_Human2.16313954
12YY1_21170310_ChIP-Seq_MESCs_Mouse2.00034592
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94227684
14CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.90152899
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88051758
16E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87725938
17MYC_18940864_ChIP-ChIP_HL60_Human1.81039439
18* DCP1A_22483619_ChIP-Seq_HELA_Human1.80638141
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80117238
20GATA1_26923725_Chip-Seq_HPCs_Mouse1.77248858
21* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76246730
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76024216
23* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73856800
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.71749258
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69921495
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68721385
27ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64021678
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62825974
29SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.59778728
30CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59574683
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.58238778
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.55065287
33DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.54185858
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54183930
35VDR_22108803_ChIP-Seq_LS180_Human1.53594940
36EWS_26573619_Chip-Seq_HEK293_Human1.53594425
37NANOG_20526341_ChIP-Seq_ESCs_Human1.50534203
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49661008
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.47184526
40* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46691956
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45695667
42REST_21632747_ChIP-Seq_MESCs_Mouse1.44783063
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.43987929
44GBX2_23144817_ChIP-Seq_PC3_Human1.43683418
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41801908
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41451899
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39907451
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39536342
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36860287
50LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36839564
51RNF2_27304074_Chip-Seq_NSC_Mouse1.36119837
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33569140
53RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.32836193
54TTF2_22483619_ChIP-Seq_HELA_Human1.31922644
55SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.31685577
56* CTCF_20526341_ChIP-Seq_ESCs_Human1.31672780
57IRF1_19129219_ChIP-ChIP_H3396_Human1.31151422
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31057328
59TAF15_26573619_Chip-Seq_HEK293_Human1.29449561
60FUS_26573619_Chip-Seq_HEK293_Human1.28407387
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28404185
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.27527883
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26129608
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.26059728
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25499586
66OCT4_20526341_ChIP-Seq_ESCs_Human1.25265348
67TP53_22573176_ChIP-Seq_HFKS_Human1.24756181
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23891582
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21635615
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20208725
71TBX5_21415370_ChIP-Seq_HL-1_Mouse1.20093008
72CIITA_25753668_ChIP-Seq_RAJI_Human1.19237394
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.19034303
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17450304
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17349477
76* XRN2_22483619_ChIP-Seq_HELA_Human1.16586915
77* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16512445
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16187369
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.16157056
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.15786307
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14859693
82SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14770159
83* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14527451
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14348733
85* GABP_19822575_ChIP-Seq_HepG2_Human1.13664775
86IGF1R_20145208_ChIP-Seq_DFB_Human1.12093715
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.11788995
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10482520
89RARB_27405468_Chip-Seq_BRAIN_Mouse1.10357255
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10072248
91P300_19829295_ChIP-Seq_ESCs_Human1.09932344
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09442983
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08278153
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07622348
95EOMES_21245162_ChIP-Seq_HESCs_Human1.07546173
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07217443
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07176849
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07143757
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06801637
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06761262
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06527290
102KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06294543
103FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06099108
104BCOR_27268052_Chip-Seq_Bcells_Human1.05270948
105CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04393170
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04071458
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03531470
108* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02889516
109FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01891328
110RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01501562
111EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01501562
112OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01492649
113EZH2_27304074_Chip-Seq_ESCs_Mouse1.01254360
114STAT1_20625510_ChIP-Seq_HELA_Human1.01138144
115CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00444406
116TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00316599
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00195673
118E2F1_20622854_ChIP-Seq_HELA_Human0.98985543
119CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98903980
120* ETS1_20019798_ChIP-Seq_JURKAT_Human0.98268902
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97524289
122FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97140712
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.95519114
124TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95487163
125DROSHA_22980978_ChIP-Seq_HELA_Human0.95472995
126TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95347936
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93803650
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93264738
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93211849
130MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92668969
131E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91508035
132JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91427335
133NCOR_22424771_ChIP-Seq_293T_Human0.90564858
134IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89905273
135SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89707634
136TET1_21490601_ChIP-Seq_MESCs_Mouse0.89118966
137BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88969032
138* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88096471
139ELK1_22589737_ChIP-Seq_MCF10A_Human0.87726221
140* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87558097
141FOXP1_21924763_ChIP-Seq_HESCs_Human0.87201466
142PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86915693
143ZNF263_19887448_ChIP-Seq_K562_Human0.86872916
144* VDR_23849224_ChIP-Seq_CD4+_Human0.86381704
145PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86202774
146FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85840750
147SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85366823
148SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85134600
149RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85121032
150* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.83195606
151P68_20966046_ChIP-Seq_HELA_Human0.82802066
152FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82644684
153AR_20517297_ChIP-Seq_VCAP_Human0.82440214
154* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82379421
155CTCF_26484167_Chip-Seq_Bcells_Mouse0.82365839
156* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.81791529
157* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.81749403
158MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.81079891
159* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.81062526
160FOXA1_25329375_ChIP-Seq_VCAP_Human0.80503040
161FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80503040
162* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.76904142
163ERG_20887958_ChIP-Seq_HPC-7_Mouse0.75065366
164NANOG_18555785_ChIP-Seq_MESCs_Mouse0.74956379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction9.83462067
2MP0002102_abnormal_ear_morphology3.09645837
3MP0005410_abnormal_fertilization2.76338284
4MP0008789_abnormal_olfactory_epithelium2.62864413
5MP0005551_abnormal_eye_electrophysiolog2.59620367
6MP0008058_abnormal_DNA_repair2.51485079
7MP0003880_abnormal_central_pattern2.42582463
8MP0003806_abnormal_nucleotide_metabolis2.34894350
9MP0005499_abnormal_olfactory_system2.18553499
10MP0005394_taste/olfaction_phenotype2.18553499
11MP0002734_abnormal_mechanical_nocicepti2.10241735
12MP0004270_analgesia2.03968213
13MP0002184_abnormal_innervation2.00604986
14MP0001529_abnormal_vocalization2.00060117
15MP0002272_abnormal_nervous_system1.92558032
16MP0006072_abnormal_retinal_apoptosis1.89476380
17MP0001905_abnormal_dopamine_level1.87626174
18MP0003646_muscle_fatigue1.83496274
19MP0005075_abnormal_melanosome_morpholog1.81028703
20MP0000920_abnormal_myelination1.77688217
21MP0001485_abnormal_pinna_reflex1.76151476
22MP0002752_abnormal_somatic_nervous1.74151463
23MP0002653_abnormal_ependyma_morphology1.67264915
24MP0002735_abnormal_chemical_nociception1.60215465
25MP0002229_neurodegeneration1.59860569
26MP0000372_irregular_coat_pigmentation1.57487669
27MP0004859_abnormal_synaptic_plasticity1.54791241
28MP0003787_abnormal_imprinting1.54701692
29MP0003786_premature_aging1.53505429
30MP0004145_abnormal_muscle_electrophysio1.51719679
31MP0002882_abnormal_neuron_morphology1.51259525
32MP0003186_abnormal_redox_activity1.50632027
33MP0003634_abnormal_glial_cell1.49467448
34MP0005171_absent_coat_pigmentation1.49136957
35MP0001986_abnormal_taste_sensitivity1.46124349
36MP0001970_abnormal_pain_threshold1.46067799
37MP0006035_abnormal_mitochondrial_morpho1.45369690
38MP0003950_abnormal_plasma_membrane1.44518830
39MP0005423_abnormal_somatic_nervous1.43448637
40MP0000465_gastrointestinal_hemorrhage1.43177439
41MP0003635_abnormal_synaptic_transmissio1.42701466
42MP0001486_abnormal_startle_reflex1.38574471
43MP0001968_abnormal_touch/_nociception1.38263872
44MP0005253_abnormal_eye_physiology1.36141113
45MP0001188_hyperpigmentation1.35892678
46MP0005195_abnormal_posterior_eye1.33976998
47MP0004142_abnormal_muscle_tone1.33308325
48MP0002095_abnormal_skin_pigmentation1.32117309
49MP0000778_abnormal_nervous_system1.30307847
50MP0003121_genomic_imprinting1.28048105
51MP0008872_abnormal_physiological_respon1.21432508
52MP0003329_amyloid_beta_deposits1.18998090
53MP0000516_abnormal_urinary_system1.17880429
54MP0005367_renal/urinary_system_phenotyp1.17880429
55MP0010094_abnormal_chromosome_stability1.17656573
56MP0003698_abnormal_male_reproductive1.15972283
57MP0002064_seizures1.14328067
58MP0004811_abnormal_neuron_physiology1.14238885
59MP0002736_abnormal_nociception_after1.11003079
60MP0002733_abnormal_thermal_nociception1.10876094
61MP0006276_abnormal_autonomic_nervous1.10498520
62MP0005671_abnormal_response_to1.10093204
63MP0001929_abnormal_gametogenesis1.08792784
64MP0003122_maternal_imprinting1.08367599
65MP0008260_abnormal_autophagy1.07949511
66MP0005646_abnormal_pituitary_gland1.07162401
67MP0002822_catalepsy1.07148226
68MP0009697_abnormal_copulation1.06635976
69MP0000955_abnormal_spinal_cord1.06015160
70MP0002210_abnormal_sex_determination1.05885240
71MP0002067_abnormal_sensory_capabilities1.05723071
72MP0002938_white_spotting1.04883759
73MP0003693_abnormal_embryo_hatching1.04137609
74MP0002063_abnormal_learning/memory/cond0.99365482
75MP0004742_abnormal_vestibular_system0.98617254
76MP0002751_abnormal_autonomic_nervous0.98431043
77MP0002160_abnormal_reproductive_system0.97303325
78MP0002138_abnormal_hepatobiliary_system0.97152646
79MP0004036_abnormal_muscle_relaxation0.96473349
80MP0002557_abnormal_social/conspecific_i0.95918938
81MP0009046_muscle_twitch0.92469270
82MP0008877_abnormal_DNA_methylation0.92339178
83MP0003718_maternal_effect0.92137526
84MP0005645_abnormal_hypothalamus_physiol0.91225882
85MP0005084_abnormal_gallbladder_morpholo0.90753639
86MP0000631_abnormal_neuroendocrine_gland0.90220549
87MP0003136_yellow_coat_color0.89371751
88MP0000358_abnormal_cell_content/0.88852304
89MP0002234_abnormal_pharynx_morphology0.88848169
90MP0005623_abnormal_meninges_morphology0.88234451
91MP0008995_early_reproductive_senescence0.88172686
92MP0002152_abnormal_brain_morphology0.88163664
93MP0001502_abnormal_circadian_rhythm0.86325617
94MP0008569_lethality_at_weaning0.86244272
95MP0010386_abnormal_urinary_bladder0.83179527
96MP0002572_abnormal_emotion/affect_behav0.82983443
97MP0000751_myopathy0.82885924
98MP0008007_abnormal_cellular_replicative0.82511777
99MP0004233_abnormal_muscle_weight0.81753632
100MP0003137_abnormal_impulse_conducting0.80538225
101MP0002161_abnormal_fertility/fecundity0.80412545
102MP0000653_abnormal_sex_gland0.79175580
103MP0004957_abnormal_blastocyst_morpholog0.78636120
104MP0000749_muscle_degeneration0.78439619
105MP0001145_abnormal_male_reproductive0.78360947
106MP0009745_abnormal_behavioral_response0.78135825
107MP0004147_increased_porphyrin_level0.78038539
108MP0008932_abnormal_embryonic_tissue0.77369809
109MP0002066_abnormal_motor_capabilities/c0.77102889
110MP0002090_abnormal_vision0.76908235
111MP0001963_abnormal_hearing_physiology0.76807046
112MP0006036_abnormal_mitochondrial_physio0.76618070
113MP0004858_abnormal_nervous_system0.76026868
114MP0003111_abnormal_nucleus_morphology0.75903317
115MP0000747_muscle_weakness0.75901297
116MP0001324_abnormal_eye_pigmentation0.75391943
117MP0006292_abnormal_olfactory_placode0.74601973
118MP0005409_darkened_coat_color0.73920710
119MP0003011_delayed_dark_adaptation0.72834971
120MP0005408_hypopigmentation0.72482354
121MP0004215_abnormal_myocardial_fiber0.71234814
122MP0009333_abnormal_splenocyte_physiolog0.71009296
123MP0002069_abnormal_eating/drinking_beha0.70592924
124MP0003077_abnormal_cell_cycle0.70213277
125MP0004885_abnormal_endolymph0.69353879
126MP0000534_abnormal_ureter_morphology0.68258092
127MP0006054_spinal_hemorrhage0.67589672
128MP0005058_abnormal_lysosome_morphology0.67429600
129MP0002638_abnormal_pupillary_reflex0.64806320
130MP0003861_abnormal_nervous_system0.63987581
131MP0003879_abnormal_hair_cell0.63707143
132MP0003942_abnormal_urinary_system0.63371182
133MP0004924_abnormal_behavior0.59916691

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.15306373
2Abnormality of macular pigmentation (HP:0008002)5.23850303
3Abnormal respiratory motile cilium physiology (HP:0012261)5.08596204
4Bony spicule pigmentary retinopathy (HP:0007737)4.51198548
5Rhinitis (HP:0012384)4.23617542
6Hepatic necrosis (HP:0002605)4.14771394
7Severe visual impairment (HP:0001141)4.12752814
8Abnormal rod and cone electroretinograms (HP:0008323)4.10132347
9Abnormal ciliary motility (HP:0012262)4.07382162
10Congenital stationary night blindness (HP:0007642)4.00903514
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.94288836
12Central scotoma (HP:0000603)3.92380706
13Limb dystonia (HP:0002451)3.90143103
14Abnormal respiratory motile cilium morphology (HP:0005938)3.66527345
15Abnormal respiratory epithelium morphology (HP:0012253)3.66527345
16Chronic bronchitis (HP:0004469)3.49704320
17Gait imbalance (HP:0002141)3.46276695
18Increased hepatocellular lipid droplets (HP:0006565)3.40340869
19Medial flaring of the eyebrow (HP:0010747)3.35785120
20Myokymia (HP:0002411)3.33615324
21Congenital primary aphakia (HP:0007707)3.30050562
22Lipid accumulation in hepatocytes (HP:0006561)3.29557447
23Dynein arm defect of respiratory motile cilia (HP:0012255)3.28854673
24Absent/shortened dynein arms (HP:0200106)3.28854673
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.27160055
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.27160055
27Increased intramyocellular lipid droplets (HP:0012240)3.22556058
28Atrophy/Degeneration involving motor neurons (HP:0007373)3.21717868
29Abnormality of the anterior horn cell (HP:0006802)3.21578302
30Degeneration of anterior horn cells (HP:0002398)3.21578302
31Cerebral edema (HP:0002181)3.13231368
32True hermaphroditism (HP:0010459)3.05420964
33Pancreatic fibrosis (HP:0100732)3.04569337
34Renal Fanconi syndrome (HP:0001994)3.03122356
35Nephrogenic diabetes insipidus (HP:0009806)2.99984220
36* Retinal dysplasia (HP:0007973)2.99301263
37Neuroendocrine neoplasm (HP:0100634)2.95722931
38Lactic acidosis (HP:0003128)2.93162064
39Amyotrophic lateral sclerosis (HP:0007354)2.91116790
40Vaginal atresia (HP:0000148)2.88699191
41Increased serum lactate (HP:0002151)2.87134846
423-Methylglutaconic aciduria (HP:0003535)2.86081601
43Scotoma (HP:0000575)2.81638168
44Cerebral hypomyelination (HP:0006808)2.80769980
45Genital tract atresia (HP:0001827)2.78649693
46Nephronophthisis (HP:0000090)2.78608536
47Respiratory failure (HP:0002878)2.70649607
48Increased muscle lipid content (HP:0009058)2.69653817
49Type I transferrin isoform profile (HP:0003642)2.65905075
50Abnormal protein glycosylation (HP:0012346)2.56768649
51Abnormal glycosylation (HP:0012345)2.56768649
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.56768649
53Abnormal protein N-linked glycosylation (HP:0012347)2.56768649
54Acute necrotizing encephalopathy (HP:0006965)2.55595753
55Pancreatic cysts (HP:0001737)2.49954793
56Exercise intolerance (HP:0003546)2.48574937
57Methylmalonic aciduria (HP:0012120)2.48019703
58Polyphagia (HP:0002591)2.42963972
59Bronchiectasis (HP:0002110)2.39983610
60Palpitations (HP:0001962)2.39476940
61Aplasia/Hypoplasia of the lens (HP:0008063)2.39173205
62Pheochromocytoma (HP:0002666)2.39160881
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38815301
64Retinitis pigmentosa (HP:0000510)2.38365543
65Aplastic anemia (HP:0001915)2.36712085
66Dysphonia (HP:0001618)2.34874807
67Severe combined immunodeficiency (HP:0004430)2.34761835
68Dyschromatopsia (HP:0007641)2.34625875
69Supranuclear gaze palsy (HP:0000605)2.33429618
70Emotional lability (HP:0000712)2.30064041
71Constricted visual fields (HP:0001133)2.29270433
72Exertional dyspnea (HP:0002875)2.27953971
73Generalized aminoaciduria (HP:0002909)2.27559487
74Abnormal mitochondria in muscle tissue (HP:0008316)2.27001447
75Ankle clonus (HP:0011448)2.24587155
76Neurofibrillary tangles (HP:0002185)2.24191056
77* Abnormality of midbrain morphology (HP:0002418)2.20778027
78* Molar tooth sign on MRI (HP:0002419)2.20778027
79CNS demyelination (HP:0007305)2.19422635
80Methylmalonic acidemia (HP:0002912)2.18665988
81Peripheral hypomyelination (HP:0007182)2.18595208
82Reduced antithrombin III activity (HP:0001976)2.17449810
83Abnormality of the fovea (HP:0000493)2.15426283
84Type II lissencephaly (HP:0007260)2.15423870
85Torticollis (HP:0000473)2.13407964
86Increased corneal curvature (HP:0100692)2.11040702
87Keratoconus (HP:0000563)2.11040702
88Microvesicular hepatic steatosis (HP:0001414)2.10508287
89Mitochondrial inheritance (HP:0001427)2.08462062
90Lethargy (HP:0001254)2.08227803
91Abnormality of dentin (HP:0010299)2.07638508
92Aplasia/Hypoplasia of the tongue (HP:0010295)2.07495656
93Poor coordination (HP:0002370)2.06369695
94Progressive macrocephaly (HP:0004481)2.03274458
95Megalencephaly (HP:0001355)2.01137965
96Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00663866
97Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00451727
98Sclerocornea (HP:0000647)1.99987584
99Short tibia (HP:0005736)1.99105656
100Progressive microcephaly (HP:0000253)1.98366417
101Hypothermia (HP:0002045)1.97857518
102Acute encephalopathy (HP:0006846)1.97294475
103Anosmia (HP:0000458)1.96634024
104Respiratory difficulties (HP:0002880)1.96587277
105* Abolished electroretinogram (ERG) (HP:0000550)1.95326064
106Abnormal number of erythroid precursors (HP:0012131)1.94170065
107X-linked dominant inheritance (HP:0001423)1.93992174
108Anencephaly (HP:0002323)1.93813962
109Abnormality of the labia minora (HP:0012880)1.90764427
110Pachygyria (HP:0001302)1.90147321
111Gliosis (HP:0002171)1.89868210
112Leukodystrophy (HP:0002415)1.87283724
113Optic disc pallor (HP:0000543)1.87069719
114Sensory axonal neuropathy (HP:0003390)1.86904605
115Craniofacial dystonia (HP:0012179)1.85881189
116Hepatocellular necrosis (HP:0001404)1.85734114
117Abnormality of alanine metabolism (HP:0010916)1.85398857
118Hyperalaninemia (HP:0003348)1.85398857
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85398857
120Pendular nystagmus (HP:0012043)1.85136406
121Dicarboxylic aciduria (HP:0003215)1.84783753
122Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84783753
123Abnormality of the renal medulla (HP:0100957)1.84346236
124Combined immunodeficiency (HP:0005387)1.83407465
125Cerebellar dysplasia (HP:0007033)1.80880515
126Colon cancer (HP:0003003)1.80300071
127* Postaxial hand polydactyly (HP:0001162)1.80004483
128Occipital encephalocele (HP:0002085)1.79412401
129Neoplasm of the adrenal gland (HP:0100631)1.79277344
130Adrenal hypoplasia (HP:0000835)1.79234097
131Cortical dysplasia (HP:0002539)1.77990373
132Abnormality of the prostate (HP:0008775)1.77718355
133Atonic seizures (HP:0010819)1.77559404
134Abnormality of cells of the erythroid lineage (HP:0012130)1.76360124
135Cystic liver disease (HP:0006706)1.76349868
136Aplasia/Hypoplasia of the tibia (HP:0005772)1.76090782
137Cellular immunodeficiency (HP:0005374)1.76087113
138Attenuation of retinal blood vessels (HP:0007843)1.75832326
139Aplasia/hypoplasia of the uterus (HP:0008684)1.75534848
140IgG deficiency (HP:0004315)1.75360589
141Hyperglycinemia (HP:0002154)1.74623739
142Delusions (HP:0000746)1.74521214
143Increased serum pyruvate (HP:0003542)1.74170487
144Abnormality of glycolysis (HP:0004366)1.74170487
145Diminished motivation (HP:0000745)1.73842551
146Abnormality of lateral ventricle (HP:0030047)1.73634841
147Supernumerary spleens (HP:0009799)1.73315616
148Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73296257
149Left ventricular hypertrophy (HP:0001712)1.72601196
150Failure to thrive in infancy (HP:0001531)1.71934993
151CNS hypomyelination (HP:0003429)1.71839153
152Pancytopenia (HP:0001876)1.70610447
153Broad-based gait (HP:0002136)1.69910934
154Apathy (HP:0000741)1.69129941
155Focal dystonia (HP:0004373)1.68779100
156Thyroiditis (HP:0100646)1.68375247
157Tongue fasciculations (HP:0001308)1.67925676
158Focal motor seizures (HP:0011153)1.67861654
159Myotonia (HP:0002486)1.67737744
160Abnormality of the motor neurons (HP:0002450)1.67298128
161Broad foot (HP:0001769)1.65789183
162Increased CSF lactate (HP:0002490)1.64941433
163Decreased central vision (HP:0007663)1.63306875
164Termporal pattern (HP:0011008)1.63118683
165Insidious onset (HP:0003587)1.63118683
166Foot dorsiflexor weakness (HP:0009027)1.62320523
167Broad distal phalanx of finger (HP:0009836)1.61313356
168Neoplasm of the peripheral nervous system (HP:0100007)1.61069302
169Prolonged QT interval (HP:0001657)1.60402115
170Type II diabetes mellitus (HP:0005978)1.59519989
171Lissencephaly (HP:0001339)1.57653504

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF4.58727655
2TRIM283.25342664
3VRK23.08355898
4BCKDK2.94889248
5LIMK12.79005257
6STK392.78294959
7CDK192.67866711
8PHKG22.63339248
9PHKG12.63339248
10BRAF2.52710452
11KDR2.47023633
12PRKD32.34082369
13CAMKK22.20834839
14TESK12.14775087
15TESK22.01222645
16MAPKAPK52.00638661
17NUAK11.98073015
18CAMK2D1.97144987
19ICK1.91904960
20CDK81.88605496
21CSNK1G31.82335682
22ILK1.81829098
23MAP4K21.81379955
24PIM21.81052987
25DYRK21.79949736
26MUSK1.68646293
27KSR21.63245131
28CSNK1A1L1.58816482
29WNK31.57622034
30SRPK11.54261056
31OXSR11.53458579
32CAMK2B1.51551887
33MAP2K71.50560761
34PRPF4B1.48490673
35CASK1.47905804
36MAP3K121.42483328
37PBK1.38637914
38CSNK1G21.37946199
39INSRR1.37382678
40MINK11.37144191
41ZAK1.36486242
42SIK31.36163281
43CAMK2G1.35184681
44NTRK11.30987218
45PAK61.30545323
46UHMK11.30459578
47PDK21.30057838
48TNIK1.30011119
49IRAK11.29371897
50STK161.29255889
51IRAK21.27810592
52MARK11.26683979
53ERBB31.25368994
54RAF11.24885175
55CCNB11.20875454
56PAK31.20061762
57MAPK151.19791712
58PINK11.19459063
59ROCK21.18365710
60CSNK1G11.17834349
61BCR1.17810994
62MST41.14947138
63CDK141.14693856
64RPS6KA41.12446733
65TXK1.11202721
66MAP3K131.03703480
67WNK41.01208660
68MAPK130.99105620
69PKN10.95988821
70PLK30.95718363
71DYRK30.94706800
72KIT0.89556990
73MAP3K90.89123824
74NTRK20.88952254
75NEK10.88533461
76DAPK10.88047779
77NEK20.87663394
78HIPK20.85345154
79TLK10.85270658
80CDK180.84032192
81MARK20.83317500
82CDK150.81191712
83MAP3K60.80741789
84AURKA0.80346309
85TGFBR10.79751812
86CDK11A0.79519018
87NME20.79092262
88MOS0.77136659
89PAK10.75660092
90ADRBK20.74728523
91BUB10.74690136
92EPHA40.73126814
93SCYL20.71593685
94FLT30.70071194
95VRK10.69740377
96CAMKK10.68811427
97CAMK2A0.68763131
98PNCK0.66558384
99GRK50.66374698
100WNK10.64952490
101TAOK30.64749425
102CDK50.62471421
103STK240.62168146
104ATR0.61004093
105SGK2230.58469992
106SGK4940.58469992
107DYRK1A0.57577026
108GRK10.57419633
109PLK10.57019866
110DAPK30.55972078
111MAP3K40.55970495
112ABL20.55712928
113EIF2AK10.55330250
114CSF1R0.54693613
115FRK0.53702499
116MAP2K20.52436794
117FES0.51630837
118CHEK20.51556227
119MAPKAPK30.50941606
120BMPR1B0.50499803
121SYK0.50400510
122TEC0.49838682
123CDK90.47542159
124CSNK1A10.47440963
125PRKG20.47097060
126CDC70.46816709
127DYRK1B0.46342596
128RPS6KA50.46328606
129WEE10.46000450
130EIF2AK30.43695872
131TAF10.43126097
132LMTK20.42890528
133DAPK20.42885026
134PRKCG0.42071126
135MAP3K10.41782689
136GRK70.40571854
137PTK2B0.39667948
138ADRBK10.38920413
139MAP3K110.38510901
140CSNK2A10.38115691
141MAP4K10.37470557
142EPHA30.36688970
143AURKB0.36653975
144PLK20.35818362
145PRKD10.35527507
146CDK30.34777408
147PLK40.34592358
148PRKD20.34419356
149CLK10.34326121
150CAMK10.34195010
151BRSK10.32700345
152TTK0.32625234
153EIF2AK20.32573298
154NME10.30968425
155TAOK10.29195116
156PRKCE0.27705589

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047406.58624271
2Phototransduction_Homo sapiens_hsa047443.69511966
3Parkinsons disease_Homo sapiens_hsa050122.16946210
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.13841876
5Ribosome_Homo sapiens_hsa030101.98478921
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.93048673
7Fatty acid elongation_Homo sapiens_hsa000621.87676344
8Oxidative phosphorylation_Homo sapiens_hsa001901.86844083
9Synaptic vesicle cycle_Homo sapiens_hsa047211.86056166
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74505921
11SNARE interactions in vesicular transport_Homo sapiens_hsa041301.66496241
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60986407
13Morphine addiction_Homo sapiens_hsa050321.58640085
14Cardiac muscle contraction_Homo sapiens_hsa042601.58108555
15Huntingtons disease_Homo sapiens_hsa050161.56593839
16Protein export_Homo sapiens_hsa030601.54160223
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50374525
18Alzheimers disease_Homo sapiens_hsa050101.45285556
19Proteasome_Homo sapiens_hsa030501.40052102
20Dopaminergic synapse_Homo sapiens_hsa047281.39216677
21GABAergic synapse_Homo sapiens_hsa047271.38537808
22Basal transcription factors_Homo sapiens_hsa030221.38378407
23Circadian entrainment_Homo sapiens_hsa047131.36256221
24Sphingolipid metabolism_Homo sapiens_hsa006001.34172754
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30097846
26Primary immunodeficiency_Homo sapiens_hsa053401.28988171
27Oocyte meiosis_Homo sapiens_hsa041141.25390599
28RNA polymerase_Homo sapiens_hsa030201.24203125
29Vibrio cholerae infection_Homo sapiens_hsa051101.24043695
30Folate biosynthesis_Homo sapiens_hsa007901.22638537
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22633835
32Glutamatergic synapse_Homo sapiens_hsa047241.22516645
33Cholinergic synapse_Homo sapiens_hsa047251.21789724
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19949636
35Serotonergic synapse_Homo sapiens_hsa047261.18241582
36Peroxisome_Homo sapiens_hsa041461.17851116
37Ovarian steroidogenesis_Homo sapiens_hsa049131.17075978
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10365716
39Ether lipid metabolism_Homo sapiens_hsa005651.08841511
40Alcoholism_Homo sapiens_hsa050341.08515384
41Nicotine addiction_Homo sapiens_hsa050331.07143865
42Insulin secretion_Homo sapiens_hsa049111.06719272
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06042969
44Asthma_Homo sapiens_hsa053101.04849363
45Sulfur metabolism_Homo sapiens_hsa009201.02274600
46* Purine metabolism_Homo sapiens_hsa002300.99301621
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98873184
48Taste transduction_Homo sapiens_hsa047420.97674250
49Sulfur relay system_Homo sapiens_hsa041220.97300213
50DNA replication_Homo sapiens_hsa030300.96166352
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93127814
52cAMP signaling pathway_Homo sapiens_hsa040240.93003658
53Rheumatoid arthritis_Homo sapiens_hsa053230.91427408
54Gap junction_Homo sapiens_hsa045400.90303530
55Propanoate metabolism_Homo sapiens_hsa006400.89898963
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86267677
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85770324
58Autoimmune thyroid disease_Homo sapiens_hsa053200.85176432
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84693263
60Pyruvate metabolism_Homo sapiens_hsa006200.84102932
61GnRH signaling pathway_Homo sapiens_hsa049120.83896252
62N-Glycan biosynthesis_Homo sapiens_hsa005100.83460443
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83064678
64Regulation of autophagy_Homo sapiens_hsa041400.82421008
65Base excision repair_Homo sapiens_hsa034100.81446875
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79888597
67Butanoate metabolism_Homo sapiens_hsa006500.79748279
68RNA transport_Homo sapiens_hsa030130.79025585
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79005716
70Cell cycle_Homo sapiens_hsa041100.77517267
71Homologous recombination_Homo sapiens_hsa034400.77193296
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.77135231
73Metabolic pathways_Homo sapiens_hsa011000.76796407
74Allograft rejection_Homo sapiens_hsa053300.76295160
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75892816
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74579031
77Glutathione metabolism_Homo sapiens_hsa004800.74500876
78Graft-versus-host disease_Homo sapiens_hsa053320.72429277
79Endocytosis_Homo sapiens_hsa041440.72316613
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71473175
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71317896
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70796859
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.69706522
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69431353
85Gastric acid secretion_Homo sapiens_hsa049710.68299452
86Antigen processing and presentation_Homo sapiens_hsa046120.67479852
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.67279258
88Nucleotide excision repair_Homo sapiens_hsa034200.67018273
89Oxytocin signaling pathway_Homo sapiens_hsa049210.66271999
90Collecting duct acid secretion_Homo sapiens_hsa049660.65977066
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65013683
92VEGF signaling pathway_Homo sapiens_hsa043700.64854401
93Nitrogen metabolism_Homo sapiens_hsa009100.63202800
94Other glycan degradation_Homo sapiens_hsa005110.63166906
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.62965192
96Salivary secretion_Homo sapiens_hsa049700.62548604
97Type I diabetes mellitus_Homo sapiens_hsa049400.62510668
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61497125
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60698990
100Biosynthesis of amino acids_Homo sapiens_hsa012300.59746597
101Ras signaling pathway_Homo sapiens_hsa040140.57360855
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56326715
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.53116849
104Hematopoietic cell lineage_Homo sapiens_hsa046400.52667799
105Pyrimidine metabolism_Homo sapiens_hsa002400.51857987
106Renal cell carcinoma_Homo sapiens_hsa052110.51621250
107Cocaine addiction_Homo sapiens_hsa050300.51611543
108Dilated cardiomyopathy_Homo sapiens_hsa054140.50825543
109Calcium signaling pathway_Homo sapiens_hsa040200.50160964
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49167161
111Amphetamine addiction_Homo sapiens_hsa050310.48630847
112Estrogen signaling pathway_Homo sapiens_hsa049150.48503326
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48199545
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.47892884
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47600878
116Axon guidance_Homo sapiens_hsa043600.46927100
117Spliceosome_Homo sapiens_hsa030400.45726239
118Chemokine signaling pathway_Homo sapiens_hsa040620.45625014
119Long-term potentiation_Homo sapiens_hsa047200.45545333
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45487185
121Arachidonic acid metabolism_Homo sapiens_hsa005900.45070610
122Mismatch repair_Homo sapiens_hsa034300.44250297
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43708438
124Dorso-ventral axis formation_Homo sapiens_hsa043200.43521568
125Fatty acid metabolism_Homo sapiens_hsa012120.43410873
126Pancreatic cancer_Homo sapiens_hsa052120.43285201
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42982530
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42527623
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42460476
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.42415620
131Salmonella infection_Homo sapiens_hsa051320.42202674
132Tryptophan metabolism_Homo sapiens_hsa003800.42046525
133Shigellosis_Homo sapiens_hsa051310.42005107
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41899477
135Carbon metabolism_Homo sapiens_hsa012000.41157682
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41153196
137Systemic lupus erythematosus_Homo sapiens_hsa053220.40077893
138Colorectal cancer_Homo sapiens_hsa052100.39720428
139RNA degradation_Homo sapiens_hsa030180.39590105
140Linoleic acid metabolism_Homo sapiens_hsa005910.39568987
141Viral myocarditis_Homo sapiens_hsa054160.38334677
142Phagosome_Homo sapiens_hsa041450.38276234
143Steroid biosynthesis_Homo sapiens_hsa001000.37870378
144Fanconi anemia pathway_Homo sapiens_hsa034600.37282173
145Melanogenesis_Homo sapiens_hsa049160.36423527
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36279316
147Epstein-Barr virus infection_Homo sapiens_hsa051690.36004609
148Non-homologous end-joining_Homo sapiens_hsa034500.35383314
149alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34921675
150Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34532834
151Lysosome_Homo sapiens_hsa041420.34177380
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33852182
153Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33545196
154Long-term depression_Homo sapiens_hsa047300.33198705
155Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33020208
156Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29806657

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