PDE7A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of granulocyte differentiation (GO:0030854)4.73298511
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.60526204
3negative regulation of T cell mediated immunity (GO:0002710)4.22700337
4mitotic sister chromatid cohesion (GO:0007064)4.14368613
5T cell migration (GO:0072678)4.08918244
6nuclear pore complex assembly (GO:0051292)4.05033734
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.03448291
8antigen processing and presentation of endogenous antigen (GO:0019883)3.96980853
9regulation of B cell differentiation (GO:0045577)3.94068679
10mucosal-associated lymphoid tissue development (GO:0048537)3.90720879
11Peyers patch development (GO:0048541)3.90720879
12positive regulation of B cell differentiation (GO:0045579)3.89564700
13nuclear pore organization (GO:0006999)3.86247943
14pre-miRNA processing (GO:0031054)3.78055642
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.72305964
16cytoplasmic mRNA processing body assembly (GO:0033962)3.68380906
17leukocyte aggregation (GO:0070486)3.65510649
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.62793596
19negative regulation of cell killing (GO:0031342)3.62793596
20negative regulation of histone methylation (GO:0031061)3.57861947
21modulation by symbiont of host defense response (GO:0052031)3.53946069
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.53946069
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.53946069
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.53946069
25modulation by symbiont of host immune response (GO:0052553)3.53946069
26positive regulation by symbiont of host defense response (GO:0052509)3.53946069
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.52285056
28positive regulation of gamma-delta T cell activation (GO:0046645)3.51992987
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.47771944
30negative regulation of erythrocyte differentiation (GO:0045647)3.46945564
31phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.42317244
32negative T cell selection (GO:0043383)3.37604117
33cellular extravasation (GO:0045123)3.33762126
34detection of other organism (GO:0098543)3.29490446
35regulation of granulocyte differentiation (GO:0030852)3.29095822
36positive regulation of alpha-beta T cell proliferation (GO:0046641)3.28301480
37regulation of RNA export from nucleus (GO:0046831)3.26631183
38histone H3-K4 trimethylation (GO:0080182)3.26286733
39negative thymic T cell selection (GO:0045060)3.24691900
40detection of bacterium (GO:0016045)3.22491691
41natural killer cell differentiation (GO:0001779)3.17906399
42regulation of histone H3-K9 methylation (GO:0051570)3.14082266
43dosage compensation (GO:0007549)3.12716085
44neutrophil activation involved in immune response (GO:0002283)3.11434799
45interkinetic nuclear migration (GO:0022027)3.06810654
46B cell proliferation (GO:0042100)3.05809116
47response to muramyl dipeptide (GO:0032495)3.04768022
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.04334390
49response to interleukin-15 (GO:0070672)3.02959689
50positive thymic T cell selection (GO:0045059)3.02406243
51positive T cell selection (GO:0043368)2.98617052
52negative regulation of leukocyte mediated immunity (GO:0002704)2.96973999
53negative regulation of interleukin-12 production (GO:0032695)2.96754228
54DNA unwinding involved in DNA replication (GO:0006268)2.96347718
55regulation of interleukin-2 biosynthetic process (GO:0045076)2.95995835
56regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95811323
57response to peptidoglycan (GO:0032494)2.92379113
58alpha-beta T cell differentiation (GO:0046632)2.91913692
59regulation of gamma-delta T cell differentiation (GO:0045586)2.91353080
60regulation of tolerance induction (GO:0002643)2.87471487
61negative regulation of translation, ncRNA-mediated (GO:0040033)2.86294223
62regulation of translation, ncRNA-mediated (GO:0045974)2.86294223
63negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86294223
64pore complex assembly (GO:0046931)2.85889412
65negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.85886680
66alpha-beta T cell activation (GO:0046631)2.85208646
67interferon-gamma production (GO:0032609)2.84822628
68activated T cell proliferation (GO:0050798)2.84817480
69positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.84605814
70type I interferon signaling pathway (GO:0060337)2.82349482
71cellular response to type I interferon (GO:0071357)2.82349482
72cellular response to interleukin-15 (GO:0071350)2.82345561
73response to type I interferon (GO:0034340)2.81939225
74histone H3-K9 methylation (GO:0051567)2.81125068
75T cell selection (GO:0045058)2.80141633
76mast cell activation (GO:0045576)2.79926387
77positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.79017250
78macrophage activation involved in immune response (GO:0002281)2.78882805
79histone H3-K36 demethylation (GO:0070544)2.78762996
80regulation of MHC class I biosynthetic process (GO:0045343)2.78023268
81DNA topological change (GO:0006265)2.77753699
82mRNA splice site selection (GO:0006376)2.76169435
83positive regulation of tolerance induction (GO:0002645)2.75876930
84histone H4-K16 acetylation (GO:0043984)2.75874515
85thymic T cell selection (GO:0045061)2.75313637
86lymphocyte homeostasis (GO:0002260)2.71819453
87positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.71662367
88T cell differentiation (GO:0030217)2.71173640
89B cell receptor signaling pathway (GO:0050853)2.70975228
90peptidyl-lysine trimethylation (GO:0018023)2.69186210
91myeloid cell activation involved in immune response (GO:0002275)2.67467697
92regulation of necroptotic process (GO:0060544)2.67121668
93alternative mRNA splicing, via spliceosome (GO:0000380)2.66633665
94regulation of regulatory T cell differentiation (GO:0045589)2.65844148
95negative regulation of adaptive immune response (GO:0002820)2.65259530
96regulation of alpha-beta T cell activation (GO:0046634)2.64586520
97response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.61085979
98response to host immune response (GO:0052572)2.61085979
99T cell proliferation (GO:0042098)2.61053518
100regulation of gamma-delta T cell activation (GO:0046643)2.60158107
101mature B cell differentiation (GO:0002335)2.59778841
1023-UTR-mediated mRNA stabilization (GO:0070935)2.59328476
103histone H3-K4 methylation (GO:0051568)2.58467695
104negative regulation of RNA splicing (GO:0033119)2.57976301
105positive regulation of alpha-beta T cell activation (GO:0046635)2.57975166
106immunoglobulin mediated immune response (GO:0016064)2.57659739
107regulation of sister chromatid cohesion (GO:0007063)2.56028055
108negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.55775353
109negative regulation of T-helper cell differentiation (GO:0045623)2.55775353
110histone H3-K9 modification (GO:0061647)2.55685212
111positive regulation of gene expression, epigenetic (GO:0045815)2.53928758
112regulation of histone methylation (GO:0031060)2.53373989
113peptidyl-lysine dimethylation (GO:0018027)2.52345624
114histone lysine methylation (GO:0034968)2.51277423
115V(D)J recombination (GO:0033151)2.51143189
116regulation of interleukin-12 biosynthetic process (GO:0045075)2.50519703
117regulation of B cell receptor signaling pathway (GO:0050855)2.47507283
118negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.47101341
119peptidyl-lysine methylation (GO:0018022)2.41344739
120regulation of T cell tolerance induction (GO:0002664)2.40931070
121positive regulation of RNA splicing (GO:0033120)2.37956843
122T cell costimulation (GO:0031295)2.37288212
123positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.36329214
124positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.36329214
125positive regulation of mitotic sister chromatid separation (GO:1901970)2.36329214
126positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.34746217
127lymphocyte costimulation (GO:0031294)2.34216556
128negative regulation of mRNA processing (GO:0050686)2.33925757
129regulation of DNA endoreduplication (GO:0032875)2.33187556
130DNA duplex unwinding (GO:0032508)2.31862531
131regulation of nucleobase-containing compound transport (GO:0032239)2.30839199
132DNA geometric change (GO:0032392)2.30603585
133regulation of histone H3-K4 methylation (GO:0051569)2.30156235
134mRNA stabilization (GO:0048255)2.29851356
135RNA stabilization (GO:0043489)2.29851356
136histone H3-K9 demethylation (GO:0033169)2.28764688
137histone lysine demethylation (GO:0070076)2.27692406
138regulation of alpha-beta T cell proliferation (GO:0046640)2.26484929
139positive regulation of histone deacetylation (GO:0031065)2.26280132
140antigen receptor-mediated signaling pathway (GO:0050851)2.25485474
141cellular response to zinc ion (GO:0071294)2.25271446
142positive regulation of interleukin-2 production (GO:0032743)2.25219237
143T cell homeostasis (GO:0043029)2.23415553
144histone mRNA catabolic process (GO:0071044)2.23406720
145regulation of mRNA stability (GO:0043488)2.22747581
146glial cell proliferation (GO:0014009)2.21247116
147histone methylation (GO:0016571)2.20191523
148regulation of histone H3-K27 methylation (GO:0061085)2.20191468
149negative regulation of histone modification (GO:0031057)2.20190507
150B cell homeostasis (GO:0001782)2.20134379
151sister chromatid segregation (GO:0000819)2.19688555
152positive regulation of chromosome segregation (GO:0051984)2.19373270
153T cell receptor signaling pathway (GO:0050852)2.18586894
154kinetochore organization (GO:0051383)2.18048962
155negative regulation of B cell proliferation (GO:0030889)2.18032369
156histone demethylation (GO:0016577)2.17497499
157chromatin assembly (GO:0031497)2.17454663
158tyrosine phosphorylation of STAT protein (GO:0007260)2.16653780
159regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.16474858
160positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.16474858
161mitotic chromosome condensation (GO:0007076)2.15974461
162regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.15170781
163positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.15170781
164positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.14396744
165tolerance induction (GO:0002507)2.14187937
166positive regulation of mRNA catabolic process (GO:0061014)2.13244209
167negative regulation of chromatin modification (GO:1903309)2.12587762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.64029221
2* FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.81128278
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.41426874
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.47488537
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.23825165
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.08165876
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.02628583
8MYC_22102868_ChIP-Seq_BL_Human2.99540666
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.92458290
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.89351564
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.79584228
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.74540786
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73858660
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.69135620
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.61777145
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.51850354
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51698938
18SPI1_23547873_ChIP-Seq_NB4_Human2.29191892
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25361537
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.25071468
21* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.24452833
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.19741597
23RUNX_20019798_ChIP-Seq_JUKART_Human2.12424897
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08859377
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08321705
26GATA1_22025678_ChIP-Seq_K562_Human2.07559849
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98519814
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96202854
29CIITA_25753668_ChIP-Seq_RAJI_Human1.84799402
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83255524
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79154646
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76641656
33MYB_26560356_Chip-Seq_TH2_Human1.74060764
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70893235
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69953186
36TCF7_22412390_ChIP-Seq_EML_Mouse1.69182598
37* SPI1_23127762_ChIP-Seq_K562_Human1.63684214
38MAF_26560356_Chip-Seq_TH1_Human1.62643028
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59844832
40VDR_24787735_ChIP-Seq_THP-1_Human1.59212566
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57439397
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.57416274
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.56485871
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56014154
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.53532647
46VDR_21846776_ChIP-Seq_THP-1_Human1.53327005
47MYB_26560356_Chip-Seq_TH1_Human1.53145203
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51954200
49GATA3_26560356_Chip-Seq_TH2_Human1.51264622
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50548914
51KDM2B_26808549_Chip-Seq_DND41_Human1.50009471
52UTX_26944678_Chip-Seq_JUKART_Human1.48592490
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.48132271
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37311847
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34812422
56PKCTHETA_26484144_Chip-Seq_BREAST_Human1.32967045
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32874984
58PU_27001747_Chip-Seq_BMDM_Mouse1.32147374
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29788805
60FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.27766930
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27309807
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.26002811
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25117601
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.23327055
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23134770
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22965036
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22808532
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22808532
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22808532
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19836945
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.19476732
72EWS_26573619_Chip-Seq_HEK293_Human1.18307236
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17856971
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17753741
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17038783
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15305069
77* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15233173
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15026708
79ELK1_19687146_ChIP-ChIP_HELA_Human1.12186137
80FUS_26573619_Chip-Seq_HEK293_Human1.10208557
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10021316
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08675832
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07977058
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07714267
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07454896
86SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06515707
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05039563
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03458254
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.02327692
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01669764
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98902856
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98850945
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98400192
94ESR1_20079471_ChIP-ChIP_T-47D_Human0.98307853
95PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98254300
96CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97390385
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97242165
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95701517
99NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94099627
100FOXP3_21729870_ChIP-Seq_TREG_Human0.94010826
101SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93910725
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93547739
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93547739
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91450044
105MAF_26560356_Chip-Seq_TH2_Human0.91285872
106GATA1_19941827_ChIP-Seq_MEL_Mouse0.91125626
107TP53_16413492_ChIP-PET_HCT116_Human0.90794146
108TCF4_18268006_ChIP-ChIP_LS174T_Human0.90506460
109POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89767400
110MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88594837
111SCL_19346495_ChIP-Seq_HPC-7_Human0.87905518
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87064953
113GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86890408
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86546709
115* VDR_24763502_ChIP-Seq_THP-1_Human0.85622851
116GATA3_27048872_Chip-Seq_THYMUS_Human0.84162675
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82908915
118BRD4_25478319_ChIP-Seq_HGPS_Human0.82095205
119RUNX1_22412390_ChIP-Seq_EML_Mouse0.81767448
120LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81650855
121IRF8_22096565_ChIP-ChIP_GC-B_Human0.81494925
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81365575
123CHD1_26751641_Chip-Seq_LNCaP_Human0.81265383
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81214087
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80959489
126SOX2_16153702_ChIP-ChIP_HESCs_Human0.80809113
127NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80312442
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80217610
129FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80078930
130GATA3_26560356_Chip-Seq_TH1_Human0.79378811
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79003843
132SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.78662181
133SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.78662181
134POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77716215
135ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77506119
136E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.77035414
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76888625
138MYC_19079543_ChIP-ChIP_MESCs_Mouse0.76550851
139ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.76266375
140NANOG_21062744_ChIP-ChIP_HESCs_Human0.76192933
141ETS1_22383799_ChIP-Seq_G1ME_Mouse0.76100543
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.76062951
143HOXB4_20404135_ChIP-ChIP_EML_Mouse0.76057955
144FLI1_27457419_Chip-Seq_LIVER_Mouse0.75663593
145VDR_23849224_ChIP-Seq_CD4+_Human0.75566452
146AHR_22903824_ChIP-Seq_MCF-7_Human0.75474496
147* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.75468936
148SMRT_27268052_Chip-Seq_Bcells_Human0.74774771
149RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74593809
150SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.74183628
151* KDM5A_27292631_Chip-Seq_BREAST_Human0.73946232
152SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.73473292
153NOTCH1_21737748_ChIP-Seq_TLL_Human0.71809145

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.03508092
2MP0000569_abnormal_digit_pigmentation2.77700378
3MP0003724_increased_susceptibility_to2.75650392
4MP0003303_peritoneal_inflammation2.71829017
5MP0003763_abnormal_thymus_physiology2.52647265
6MP0008057_abnormal_DNA_replication2.52311598
7MP0000537_abnormal_urethra_morphology2.42028935
8MP0003436_decreased_susceptibility_to2.38336530
9MP0003121_genomic_imprinting2.32734333
10MP0010094_abnormal_chromosome_stability2.11488065
11MP0005025_abnormal_response_to2.09042046
12MP0002419_abnormal_innate_immunity2.03876704
13MP0005076_abnormal_cell_differentiation1.99820717
14MP0000733_abnormal_muscle_development1.98478882
15MP0009785_altered_susceptibility_to1.88373736
16MP0003077_abnormal_cell_cycle1.88333663
17MP0004381_abnormal_hair_follicle1.84685888
18* MP0001800_abnormal_humoral_immune1.83886863
19MP0001790_abnormal_immune_system1.82769417
20MP0005387_immune_system_phenotype1.82769417
21MP0002396_abnormal_hematopoietic_system1.80813723
22MP0010352_gastrointestinal_tract_polyps1.80064613
23MP0000685_abnormal_immune_system1.76185537
24MP0003828_pulmonary_edema1.74458415
25MP0000703_abnormal_thymus_morphology1.68388649
26MP0003567_abnormal_fetal_cardiomyocyte1.65111211
27MP0010234_abnormal_vibrissa_follicle1.62793963
28MP0009333_abnormal_splenocyte_physiolog1.62551254
29MP0002009_preneoplasia1.62250638
30MP0003111_abnormal_nucleus_morphology1.61799300
31MP0005075_abnormal_melanosome_morpholog1.58277337
32MP0004808_abnormal_hematopoietic_stem1.58246485
33MP0002398_abnormal_bone_marrow1.54902101
34MP0002166_altered_tumor_susceptibility1.53007187
35MP0004197_abnormal_fetal_growth/weight/1.45480743
36MP0002148_abnormal_hypersensitivity_rea1.42960405
37MP0003646_muscle_fatigue1.41630431
38MP0003890_abnormal_embryonic-extraembry1.39523278
39MP0005397_hematopoietic_system_phenotyp1.36337376
40MP0001545_abnormal_hematopoietic_system1.36337376
41MP0008877_abnormal_DNA_methylation1.35779274
42MP0002452_abnormal_antigen_presenting1.33453679
43MP0001835_abnormal_antigen_presentation1.32206489
44MP0003866_abnormal_defecation1.31038562
45MP0002420_abnormal_adaptive_immunity1.27861777
46MP0004947_skin_inflammation1.26859697
47MP0003221_abnormal_cardiomyocyte_apopto1.26352646
48MP0005671_abnormal_response_to1.26000371
49MP0004130_abnormal_muscle_cell1.25823954
50MP0008961_abnormal_basal_metabolism1.25663554
51MP0009703_decreased_birth_body1.25146889
52MP0005310_abnormal_salivary_gland1.25069529
53MP0000716_abnormal_immune_system1.24017840
54MP0003123_paternal_imprinting1.23737348
55MP0001845_abnormal_inflammatory_respons1.23287732
56MP0000350_abnormal_cell_proliferation1.22964977
57MP0001819_abnormal_immune_cell1.22571367
58MP0008058_abnormal_DNA_repair1.22131657
59MP0008260_abnormal_autophagy1.22029706
60MP0001851_eye_inflammation1.20715818
61MP0005464_abnormal_platelet_physiology1.20170769
62MP0003385_abnormal_body_wall1.19232215
63MP0003937_abnormal_limbs/digits/tail_de1.18721488
64MP0004185_abnormal_adipocyte_glucose1.18354007
65MP0008007_abnormal_cellular_replicative1.17025802
66MP0003935_abnormal_craniofacial_develop1.15278936
67MP0001730_embryonic_growth_arrest1.15184126
68MP0002084_abnormal_developmental_patter1.15086447
69MP0000428_abnormal_craniofacial_morphol1.14901079
70MP0002006_tumorigenesis1.13711325
71MP0010678_abnormal_skin_adnexa1.13289728
72MP0003656_abnormal_erythrocyte_physiolo1.12491116
73MP0002085_abnormal_embryonic_tissue1.12163081
74MP0000778_abnormal_nervous_system1.10192144
75MP0002723_abnormal_immune_serum1.09771031
76MP0002722_abnormal_immune_system1.08994942
77MP0006082_CNS_inflammation1.08053593
78MP0006292_abnormal_olfactory_placode1.06648319
79MP0000689_abnormal_spleen_morphology1.06340123
80MP0000383_abnormal_hair_follicle1.06233289
81MP0002925_abnormal_cardiovascular_devel1.05544252
82MP0001672_abnormal_embryogenesis/_devel1.05423996
83MP0005380_embryogenesis_phenotype1.05423996
84MP0001873_stomach_inflammation1.05186337
85MP0000490_abnormal_crypts_of1.05071525
86MP0002088_abnormal_embryonic_growth/wei1.04978715
87MP0009672_abnormal_birth_weight1.03780636
88MP0002019_abnormal_tumor_incidence1.03599240
89MP0003984_embryonic_growth_retardation1.03554541
90MP0004084_abnormal_cardiac_muscle1.01224278
91MP0003300_gastrointestinal_ulcer1.00760724
92MP0005451_abnormal_body_composition0.98584096
93MP0003091_abnormal_cell_migration0.97657264
94MP0003941_abnormal_skin_development0.97616118
95MP0004957_abnormal_blastocyst_morpholog0.96818413
96MP0002429_abnormal_blood_cell0.96597579
97MP0010630_abnormal_cardiac_muscle0.96597049
98MP0000432_abnormal_head_morphology0.95625917
99MP0001293_anophthalmia0.95546562
100MP0003861_abnormal_nervous_system0.94328560
101MP0005000_abnormal_immune_tolerance0.93868149
102MP0002086_abnormal_extraembryonic_tissu0.92045513
103MP0001697_abnormal_embryo_size0.91526253
104MP0003755_abnormal_palate_morphology0.89135617
105MP0004134_abnormal_chest_morphology0.88328713
106MP0004087_abnormal_muscle_fiber0.87561975
107MP0009278_abnormal_bone_marrow0.87277550
108MP0010307_abnormal_tumor_latency0.86632641
109MP0002106_abnormal_muscle_physiology0.86478397
110MP0000465_gastrointestinal_hemorrhage0.85596461
111MP0002932_abnormal_joint_morphology0.85558877
112MP0001853_heart_inflammation0.85485863
113MP0003938_abnormal_ear_development0.84284105
114MP0000759_abnormal_skeletal_muscle0.84002670
115MP0002163_abnormal_gland_morphology0.83593299
116MP0006054_spinal_hemorrhage0.81973156
117MP0003115_abnormal_respiratory_system0.80465541
118MP0004484_altered_response_of0.79451072
119MP0001784_abnormal_fluid_regulation0.79110008
120MP0002177_abnormal_outer_ear0.78459090
121MP0001879_abnormal_lymphatic_vessel0.78342946
122MP0002933_joint_inflammation0.78264736
123MP0004145_abnormal_muscle_electrophysio0.77618128
124MP0000858_altered_metastatic_potential0.77419253
125MP0002405_respiratory_system_inflammati0.77327698
126MP0002116_abnormal_craniofacial_bone0.76944501
127MP0000751_myopathy0.76827430
128MP0008469_abnormal_protein_level0.76551345
129MP0004883_abnormal_blood_vessel0.76148502
130MP0003122_maternal_imprinting0.75839085
131MP0001286_abnormal_eye_development0.75666385
132MP0002233_abnormal_nose_morphology0.75161917
133MP0010155_abnormal_intestine_physiology0.74395852
134MP0001299_abnormal_eye_distance/0.74261102
135MP0000566_synostosis0.73661992
136MP0002080_prenatal_lethality0.73638665
137MP0008789_abnormal_olfactory_epithelium0.73287883
138MP0005174_abnormal_tail_pigmentation0.73159730
139MP0004036_abnormal_muscle_relaxation0.73040656
140MP0002998_abnormal_bone_remodeling0.73029319
141MP0000313_abnormal_cell_death0.73018578
142MP0001533_abnormal_skeleton_physiology0.72510857
143MP0002092_abnormal_eye_morphology0.72250495
144MP0002277_abnormal_respiratory_mucosa0.70262765
145MP0003183_abnormal_peptide_metabolism0.69932169
146MP0002132_abnormal_respiratory_system0.69675617
147MP0008995_early_reproductive_senescence0.66291591
148MP0009764_decreased_sensitivity_to0.65187520
149MP0002138_abnormal_hepatobiliary_system0.65152426
150MP0004510_myositis0.62523460
151MP0000015_abnormal_ear_pigmentation0.60903685
152MP0003172_abnormal_lysosome_physiology0.59401332
153MP0005666_abnormal_adipose_tissue0.59372044
154MP0002127_abnormal_cardiovascular_syste0.59212138
155MP0001663_abnormal_digestive_system0.53364550

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.41755538
2Recurrent bacterial skin infections (HP:0005406)4.09516626
3Recurrent abscess formation (HP:0002722)3.91359720
4Meningitis (HP:0001287)3.46444564
5Myositis (HP:0100614)3.45043557
6Encephalitis (HP:0002383)3.42220695
7Stomatitis (HP:0010280)3.40241514
8Retrobulbar optic neuritis (HP:0100654)3.29863967
9Optic neuritis (HP:0100653)3.29863967
10Gastrointestinal infarctions (HP:0005244)3.17875605
11Abnormality of the fingertips (HP:0001211)3.17431100
12Mediastinal lymphadenopathy (HP:0100721)3.15041100
13Elevated erythrocyte sedimentation rate (HP:0003565)3.14642877
14Recurrent skin infections (HP:0001581)3.00638588
15Orchitis (HP:0100796)2.92032661
16Vasculitis (HP:0002633)2.91706103
17Acute lymphatic leukemia (HP:0006721)2.91214773
18Spontaneous hematomas (HP:0007420)2.88623015
19Volvulus (HP:0002580)2.84649607
20Autoimmune hemolytic anemia (HP:0001890)2.81552659
21Leukocytosis (HP:0001974)2.75290440
22Short 4th metacarpal (HP:0010044)2.72639585
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.72639585
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.72572178
25Chest pain (HP:0100749)2.72034805
26T lymphocytopenia (HP:0005403)2.71542524
27IgG deficiency (HP:0004315)2.69702157
28Pustule (HP:0200039)2.63610184
29Granulocytopenia (HP:0001913)2.58788478
30Papilledema (HP:0001085)2.56038186
31Keratoconjunctivitis sicca (HP:0001097)2.55066638
32Thyroiditis (HP:0100646)2.50841444
33Colon cancer (HP:0003003)2.49303372
34Spinal cord lesions (HP:0100561)2.48660155
35Syringomyelia (HP:0003396)2.48660155
36Hypochromic microcytic anemia (HP:0004840)2.44864338
37Abnormality of T cell number (HP:0011839)2.44845458
38Recurrent gram-negative bacterial infections (HP:0005420)2.43121419
39Abnormality of T cell physiology (HP:0011840)2.42986000
40Agammaglobulinemia (HP:0004432)2.42499293
41Increased IgE level (HP:0003212)2.42142991
42Abnormality of eosinophils (HP:0001879)2.40711674
43Hypoplasia of the thymus (HP:0000778)2.38360030
44Increased density of long bones (HP:0006392)2.36798890
45Amaurosis fugax (HP:0100576)2.36057222
46Increased IgM level (HP:0003496)2.33462581
47Cellulitis (HP:0100658)2.32509487
48Panhypogammaglobulinemia (HP:0003139)2.32134103
49Keratoconjunctivitis (HP:0001096)2.32115818
50B lymphocytopenia (HP:0010976)2.32074127
51Abnormality of B cell number (HP:0010975)2.32074127
52Chronic obstructive pulmonary disease (HP:0006510)2.31662691
53Obstructive lung disease (HP:0006536)2.31662691
54Eosinophilia (HP:0001880)2.29632076
55Acute myeloid leukemia (HP:0004808)2.29407564
56Recurrent bronchitis (HP:0002837)2.28921704
57IgA deficiency (HP:0002720)2.28541829
58Supernumerary ribs (HP:0005815)2.28076514
59Arterial thrombosis (HP:0004420)2.28075372
60Chronic otitis media (HP:0000389)2.26327423
61Trigonocephaly (HP:0000243)2.24416534
62Ectopic kidney (HP:0000086)2.24312711
63Abnormality of macrophages (HP:0004311)2.21430377
64Hypochromic anemia (HP:0001931)2.19919056
65Macroorchidism (HP:0000053)2.19671119
66Long clavicles (HP:0000890)2.15301212
67Abnormality of the 4th metacarpal (HP:0010012)2.14386757
68Ependymoma (HP:0002888)2.14194724
69Prolonged bleeding time (HP:0003010)2.14065707
70Long eyelashes (HP:0000527)2.11818072
71Absent frontal sinuses (HP:0002688)2.11545779
72Supernumerary bones of the axial skeleton (HP:0009144)2.10038763
73Medulloblastoma (HP:0002885)2.09973307
74Pelvic girdle muscle weakness (HP:0003749)2.09170271
75Muscle fiber inclusion bodies (HP:0100299)2.08994173
76Aplasia/Hypoplasia of the thymus (HP:0010515)2.07446401
77Gingivitis (HP:0000230)2.06770620
78Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.05193672
79Gastrointestinal stroma tumor (HP:0100723)2.04641585
80Heterotopia (HP:0002282)2.04527506
81Osteomyelitis (HP:0002754)2.04082660
82Hemoptysis (HP:0002105)2.03533575
83Recurrent viral infections (HP:0004429)2.03113856
84Lip pit (HP:0100267)2.02648338
85Pulmonary infiltrates (HP:0002113)2.00787343
86Abnormal hair whorl (HP:0010721)2.00771228
87Subacute progressive viral hepatitis (HP:0006572)2.00681538
88Autoimmune thrombocytopenia (HP:0001973)1.95517915
89Narrow palate (HP:0000189)1.95009641
90Nemaline bodies (HP:0003798)1.94657242
91Hyperacusis (HP:0010780)1.93898820
92Increased nuchal translucency (HP:0010880)1.92660063
93Severe combined immunodeficiency (HP:0004430)1.90320910
94Urticaria (HP:0001025)1.90181867
95Neoplasm of the tracheobronchial system (HP:0100552)1.89966583
96Acute hepatic failure (HP:0006554)1.88793086
97Astrocytoma (HP:0009592)1.88188082
98Abnormality of the astrocytes (HP:0100707)1.88188082
99Pulmonary embolism (HP:0002204)1.87614420
100Abnormality of the hip-girdle musculature (HP:0001445)1.87114371
101Abnormality of the musculature of the pelvis (HP:0001469)1.87114371
102Abnormality of the intervertebral disk (HP:0005108)1.86700109
103Inflammation of the large intestine (HP:0002037)1.86510559
104Abnormal delayed hypersensitivity skin test (HP:0002963)1.85773016
105Bronchitis (HP:0012387)1.85678347
106Cutis marmorata (HP:0000965)1.85381438
107Abnormality of the thymus (HP:0000777)1.82310005
108Large earlobe (HP:0009748)1.81862172
109Papillary thyroid carcinoma (HP:0002895)1.80643033
110Fatigue (HP:0012378)1.80473079
111Sepsis (HP:0100806)1.80096110
112Proximal placement of thumb (HP:0009623)1.79400874
113Gastrointestinal inflammation (HP:0004386)1.78158306
114Thrombocytosis (HP:0001894)1.77916973
115Viral hepatitis (HP:0006562)1.77375692
116Skull defect (HP:0001362)1.77063789
117Esophageal atresia (HP:0002032)1.76402397
118Microcytic anemia (HP:0001935)1.76395269
119Epistaxis (HP:0000421)1.75718924
120Shoulder girdle muscle weakness (HP:0003547)1.75690792
121Recurrent sinusitis (HP:0011108)1.75483543
122Obsessive-compulsive behavior (HP:0000722)1.74674211
123Deviation of the thumb (HP:0009603)1.74394547
124Abnormality of the endocardium (HP:0004306)1.74372584
125IgM deficiency (HP:0002850)1.74367530
126Verrucae (HP:0200043)1.74113192
127Papilloma (HP:0012740)1.74113192
128Lymphopenia (HP:0001888)1.73646016
129Persistence of primary teeth (HP:0006335)1.73178183
130Hypoplastic labia majora (HP:0000059)1.72747394
131Vertebral arch anomaly (HP:0008438)1.72042132
132Gastrointestinal carcinoma (HP:0002672)1.71407749
133Malignant gastrointestinal tract tumors (HP:0006749)1.71407749
134Biliary tract neoplasm (HP:0100574)1.69490193
135Basal cell carcinoma (HP:0002671)1.69374125
136Renal duplication (HP:0000075)1.66311044
137Overriding aorta (HP:0002623)1.65318535
138Combined immunodeficiency (HP:0005387)1.65076456
139Glioma (HP:0009733)1.64490638
140Prominent nose (HP:0000448)1.62519163
141Elfin facies (HP:0004428)1.61926206
142Exercise-induced myalgia (HP:0003738)1.61901061
143Abnormality of cells of the lymphoid lineage (HP:0012140)1.61449072
144Midline defect of the nose (HP:0004122)1.60834967
145Depressed nasal tip (HP:0000437)1.60611930
146Tented upper lip vermilion (HP:0010804)1.58531394
147Lymphoma (HP:0002665)1.58106511
148Abnormality of the nasal septum (HP:0000419)1.57860667
149Recurrent fungal infections (HP:0002841)1.57708737
150Low anterior hairline (HP:0000294)1.57476224
151Aqueductal stenosis (HP:0002410)1.56883141
152Abnormality of the parietal bone (HP:0002696)1.56727182
153Abnormality of the labia majora (HP:0012881)1.56398001
154Limited elbow extension (HP:0001377)1.56372042
155Deep philtrum (HP:0002002)1.56357396
156Subaortic stenosis (HP:0001682)1.56006308
157Abnormality of the left ventricular outflow tract (HP:0011103)1.56006308
158Stomach cancer (HP:0012126)1.55090122
159Inappropriate behavior (HP:0000719)1.55044502
160Tapered finger (HP:0001182)1.54462074
161Ureteral stenosis (HP:0000071)1.52951367
162Recurrent cutaneous fungal infections (HP:0011370)1.52779912
163Chronic mucocutaneous candidiasis (HP:0002728)1.52779912
164Colitis (HP:0002583)1.52707486
165Abnormality of T cells (HP:0002843)1.52554676
166Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.52410150
167Shallow orbits (HP:0000586)1.52067495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.60651201
2CDK123.31410514
3MAP4K13.30995099
4TTN2.64147453
5MAP3K102.57827402
6BRD42.44836437
7PRPF4B2.36109588
8SIK22.25284390
9FGFR22.22811884
10TAOK32.18191048
11CDC72.10263189
12STK102.05193291
13IKBKE1.94869667
14FES1.93940762
15BLK1.88084012
16EEF2K1.81988906
17ERBB31.81364489
18TXK1.77514944
19ITK1.75473803
20GRK61.67546724
21FGFR31.62122856
22NEK21.59285008
23ZAP701.58340707
24KIT1.56707405
25ICK1.55977318
26CAMK1G1.48714434
27TNIK1.46148977
28IRAK41.44166954
29SRPK11.33967074
30CAMK1D1.33902686
31MAP2K31.31620056
32TYRO31.31343588
33MKNK11.29667386
34JAK31.26778885
35PKN21.25616081
36CDK61.25152111
37CSNK1A1L1.24363794
38MST41.22476847
39LYN1.14581439
40PTK61.13056923
41MELK1.10848569
42TNK21.07692074
43ATR1.07584357
44ALK1.06788027
45LRRK21.05759922
46CDK191.05634629
47MAP3K71.04882042
48MKNK21.03228253
49PIK3CG1.01538958
50CLK10.98632329
51STK40.98569822
52JAK20.97352221
53CDK40.97267582
54NLK0.95567492
55SIK30.94880321
56WNK10.94505262
57OBSCN0.93898145
58MAP3K140.93638597
59FGFR10.91690864
60PRKCQ0.90155455
61SGK30.88931503
62MARK10.87847515
63PKN10.87409334
64FGR0.87095953
65BTK0.87031098
66PDGFRB0.86338120
67CHEK10.85016755
68MAP3K130.84895077
69EPHB10.84886261
70TAF10.84280397
71MAPK70.84263900
72EPHB20.83461824
73MAPK120.83449733
74DMPK0.82167979
75CSK0.80942443
76CHEK20.80169785
77MARK30.79679497
78JAK10.79667203
79ATM0.79341352
80CDK90.79181763
81LATS10.79111496
82MTOR0.78913747
83YES10.78327046
84IKBKB0.77345890
85CSNK1D0.76666931
86TBK10.75362911
87CSF1R0.74765543
88HIPK20.74408351
89STK240.73535224
90LCK0.73163190
91TLK10.72894057
92DYRK30.72890535
93MATK0.72631108
94CSNK1G10.72466775
95FGFR40.71905762
96TSSK60.70450122
97RPS6KB20.70048476
98STK110.68656523
99UHMK10.67767542
100CHUK0.66323285
101TEC0.66023674
102HCK0.65910341
103MAPK130.65057101
104SGK20.63789119
105CAMKK20.62990629
106MARK20.62279003
107RPS6KC10.62020441
108RPS6KL10.62020441
109CSNK1G30.61710330
110PIM10.61417459
111PHKG10.61152806
112PHKG20.61152806
113CDC42BPA0.61045474
114TGFBR10.60042398
115CAMKK10.59277366
116SMG10.59184670
117CDK10.59039005
118CDK20.58409718
119TRPM70.57121923
120PNCK0.56273037
121RPS6KA60.56186743
122RPS6KA40.54242730
123DYRK1B0.53791914
124MAP2K60.53445408
125SYK0.52781936
126MAP3K80.52774083
127IRAK10.52165790
128MAPK80.51716864
129BMX0.51429830
130STK30.49827682
131SGK2230.49498367
132SGK4940.49498367
133PASK0.48809305
134TGFBR20.48759071
135TRIB30.46950968
136TYK20.46918156
137CAMK40.45823184
138MAPK110.41352981
139PDK10.39380317
140PRKCH0.39192420
141EGFR0.38779691
142BCKDK0.38591878
143EIF2AK30.38311273
144SGK10.37398519
145BMPR20.34986078
146RPS6KA10.34647231

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.57284427
2B cell receptor signaling pathway_Homo sapiens_hsa046622.06022974
3T cell receptor signaling pathway_Homo sapiens_hsa046602.03694254
4RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.72501913
5Viral myocarditis_Homo sapiens_hsa054161.70598496
6mRNA surveillance pathway_Homo sapiens_hsa030151.64693420
7Non-homologous end-joining_Homo sapiens_hsa034501.62264148
8Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57831720
9Spliceosome_Homo sapiens_hsa030401.48372898
10MicroRNAs in cancer_Homo sapiens_hsa052061.44385356
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.43357089
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40988792
13Chronic myeloid leukemia_Homo sapiens_hsa052201.40449654
14Colorectal cancer_Homo sapiens_hsa052101.37309972
15Tuberculosis_Homo sapiens_hsa051521.34808336
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34496451
17Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31754188
18Adherens junction_Homo sapiens_hsa045201.31377685
19Mismatch repair_Homo sapiens_hsa034301.30455681
20Type I diabetes mellitus_Homo sapiens_hsa049401.28806829
21Basal cell carcinoma_Homo sapiens_hsa052171.28586803
22Asthma_Homo sapiens_hsa053101.26302262
23Measles_Homo sapiens_hsa051621.24916013
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.23447688
25Endometrial cancer_Homo sapiens_hsa052131.23226709
26Cell cycle_Homo sapiens_hsa041101.21666015
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21580747
28HTLV-I infection_Homo sapiens_hsa051661.20030664
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.19697150
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19120484
31Hematopoietic cell lineage_Homo sapiens_hsa046401.18162371
32Notch signaling pathway_Homo sapiens_hsa043301.17450643
33Antigen processing and presentation_Homo sapiens_hsa046121.16616706
34Axon guidance_Homo sapiens_hsa043601.16549343
35Small cell lung cancer_Homo sapiens_hsa052221.16418562
36Viral carcinogenesis_Homo sapiens_hsa052031.16140774
37Herpes simplex infection_Homo sapiens_hsa051681.15634218
38Non-small cell lung cancer_Homo sapiens_hsa052231.14849705
39Renal cell carcinoma_Homo sapiens_hsa052111.13806874
40Thyroid cancer_Homo sapiens_hsa052161.13414049
41Staphylococcus aureus infection_Homo sapiens_hsa051501.12610340
42Pancreatic cancer_Homo sapiens_hsa052121.10455198
43Osteoclast differentiation_Homo sapiens_hsa043801.08479448
44Systemic lupus erythematosus_Homo sapiens_hsa053221.08207628
45Proteoglycans in cancer_Homo sapiens_hsa052051.07066527
46Prostate cancer_Homo sapiens_hsa052151.06295591
47Acute myeloid leukemia_Homo sapiens_hsa052211.06123969
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04296406
49DNA replication_Homo sapiens_hsa030301.04210006
50Fanconi anemia pathway_Homo sapiens_hsa034601.03902424
51Epstein-Barr virus infection_Homo sapiens_hsa051691.03296022
52RNA transport_Homo sapiens_hsa030131.02968024
53Inositol phosphate metabolism_Homo sapiens_hsa005621.02529072
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.02134082
55Hippo signaling pathway_Homo sapiens_hsa043901.01913798
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01492872
57FoxO signaling pathway_Homo sapiens_hsa040680.99841862
58Toxoplasmosis_Homo sapiens_hsa051450.99520277
59Base excision repair_Homo sapiens_hsa034100.99293258
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98368684
61RNA degradation_Homo sapiens_hsa030180.97629867
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97365384
63Wnt signaling pathway_Homo sapiens_hsa043100.96617446
64Lysine degradation_Homo sapiens_hsa003100.96004104
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95773862
66Homologous recombination_Homo sapiens_hsa034400.94987041
67Hepatitis B_Homo sapiens_hsa051610.94342182
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94168609
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.93647323
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93463322
71Chemokine signaling pathway_Homo sapiens_hsa040620.93047948
72ErbB signaling pathway_Homo sapiens_hsa040120.91637763
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90657378
74mTOR signaling pathway_Homo sapiens_hsa041500.89615397
75Focal adhesion_Homo sapiens_hsa045100.87935156
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87057033
77Autoimmune thyroid disease_Homo sapiens_hsa053200.86553500
78Pathways in cancer_Homo sapiens_hsa052000.86265346
79Dorso-ventral axis formation_Homo sapiens_hsa043200.86122763
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85865256
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85831423
82MAPK signaling pathway_Homo sapiens_hsa040100.83880912
83Platelet activation_Homo sapiens_hsa046110.82502103
84Tight junction_Homo sapiens_hsa045300.81479702
85Leishmaniasis_Homo sapiens_hsa051400.80613267
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79866540
87TGF-beta signaling pathway_Homo sapiens_hsa043500.79256612
88Malaria_Homo sapiens_hsa051440.78292330
89Legionellosis_Homo sapiens_hsa051340.76688782
90VEGF signaling pathway_Homo sapiens_hsa043700.76201007
91Prolactin signaling pathway_Homo sapiens_hsa049170.76122357
92Shigellosis_Homo sapiens_hsa051310.74715476
93Glioma_Homo sapiens_hsa052140.74611820
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73286706
95Apoptosis_Homo sapiens_hsa042100.72031457
96Graft-versus-host disease_Homo sapiens_hsa053320.71407459
97Hedgehog signaling pathway_Homo sapiens_hsa043400.70963832
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70766333
99Alcoholism_Homo sapiens_hsa050340.70626732
100Influenza A_Homo sapiens_hsa051640.70478300
101TNF signaling pathway_Homo sapiens_hsa046680.70423602
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69802316
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69110778
104Dilated cardiomyopathy_Homo sapiens_hsa054140.68450959
105p53 signaling pathway_Homo sapiens_hsa041150.68195908
106Insulin resistance_Homo sapiens_hsa049310.66825183
107Choline metabolism in cancer_Homo sapiens_hsa052310.66162762
108Hepatitis C_Homo sapiens_hsa051600.63636481
109Nucleotide excision repair_Homo sapiens_hsa034200.61978000
110Allograft rejection_Homo sapiens_hsa053300.61604740
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61437165
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60675723
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.60326433
114Rap1 signaling pathway_Homo sapiens_hsa040150.60045106
115Long-term potentiation_Homo sapiens_hsa047200.59172738
116African trypanosomiasis_Homo sapiens_hsa051430.58589322
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55662100
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55324583
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54697445
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.49130010
121Regulation of autophagy_Homo sapiens_hsa041400.45928334
122Ribosome_Homo sapiens_hsa030100.45849871
123GnRH signaling pathway_Homo sapiens_hsa049120.42420289
124HIF-1 signaling pathway_Homo sapiens_hsa040660.40379812
125Insulin signaling pathway_Homo sapiens_hsa049100.39685598

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