PDE7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of synapse structural plasticity (GO:0051823)5.10154492
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.89145858
3locomotory exploration behavior (GO:0035641)4.52633414
4prepulse inhibition (GO:0060134)4.44910111
5membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.38759481
6synaptic vesicle maturation (GO:0016188)4.34004970
7neurotransmitter-gated ion channel clustering (GO:0072578)4.26873795
8vocalization behavior (GO:0071625)4.25678130
9striatum development (GO:0021756)4.20925081
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.20489769
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.16376217
12synaptic transmission, dopaminergic (GO:0001963)4.08061034
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.04250176
14regulation of glutamate receptor signaling pathway (GO:1900449)3.99387704
15auditory behavior (GO:0031223)3.98298820
16negative regulation of cytosolic calcium ion concentration (GO:0051481)3.97217762
17regulation of long-term neuronal synaptic plasticity (GO:0048169)3.88910732
18positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.87058516
19adenosine receptor signaling pathway (GO:0001973)3.82650325
20adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.79843680
21response to auditory stimulus (GO:0010996)3.70359368
22positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.67311277
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.64497778
24regulation of neuronal synaptic plasticity (GO:0048168)3.62886777
25negative regulation of synaptic transmission, GABAergic (GO:0032229)3.58441042
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.56609710
27synaptic vesicle exocytosis (GO:0016079)3.53484495
28positive regulation of synaptic transmission, GABAergic (GO:0032230)3.52811960
29regulation of dendritic spine morphogenesis (GO:0061001)3.51373244
30positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.48183186
31detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.45675072
32regulation of cell communication by electrical coupling (GO:0010649)3.43794434
33G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.40176395
34behavioral response to cocaine (GO:0048148)3.39296452
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38935352
36response to amphetamine (GO:0001975)3.38427723
37negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.37064607
38dopamine receptor signaling pathway (GO:0007212)3.37016783
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.36632996
40regulation of synaptic vesicle exocytosis (GO:2000300)3.33829429
41positive regulation of membrane potential (GO:0045838)3.30655937
42neuromuscular process controlling balance (GO:0050885)3.29037207
43neuronal action potential propagation (GO:0019227)3.28794406
44protein localization to synapse (GO:0035418)3.28655380
45regulation of synaptic transmission, glutamatergic (GO:0051966)3.28600543
46regulation of female receptivity (GO:0045924)3.26771262
47neuron-neuron synaptic transmission (GO:0007270)3.25661049
48* cAMP catabolic process (GO:0006198)3.25505442
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24731450
50positive regulation of neurotransmitter transport (GO:0051590)3.23231624
51presynaptic membrane assembly (GO:0097105)3.20966843
52dendritic spine morphogenesis (GO:0060997)3.17132597
53glutamate receptor signaling pathway (GO:0007215)3.16006000
54neurotransmitter secretion (GO:0007269)3.15271945
55regulation of postsynaptic membrane potential (GO:0060078)3.15157442
56negative regulation of axon extension involved in axon guidance (GO:0048843)3.15095138
57long-term memory (GO:0007616)3.12213092
58protein K11-linked deubiquitination (GO:0035871)3.11149635
59synaptic transmission, glutamatergic (GO:0035249)3.10697801
60gamma-aminobutyric acid transport (GO:0015812)3.07599050
61regulation of voltage-gated calcium channel activity (GO:1901385)3.05917207
62exploration behavior (GO:0035640)3.05437811
63glutamate secretion (GO:0014047)3.05377367
64regulation of relaxation of muscle (GO:1901077)3.01395811
65regulation of synaptic vesicle transport (GO:1902803)3.01338229
66cellular potassium ion homeostasis (GO:0030007)3.01020453
67substrate-independent telencephalic tangential migration (GO:0021826)2.96792924
68substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.96792924
69neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.95052626
70female mating behavior (GO:0060180)2.94586276
71response to histamine (GO:0034776)2.94139567
72regulation of neurotransmitter uptake (GO:0051580)2.93520179
73activation of protein kinase A activity (GO:0034199)2.92751469
74dermatan sulfate biosynthetic process (GO:0030208)2.92051647
75regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.91086254
76regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.91086254
77positive regulation of neurotransmitter secretion (GO:0001956)2.88151494
78regulation of synaptic plasticity (GO:0048167)2.88092356
79regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.86151863
80regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.85592020
81regulation of membrane repolarization (GO:0060306)2.84933654
82regulation of glutamate secretion (GO:0014048)2.84758572
83membrane hyperpolarization (GO:0060081)2.84573622
84transmission of nerve impulse (GO:0019226)2.84346855
85layer formation in cerebral cortex (GO:0021819)2.83542598
86neuronal ion channel clustering (GO:0045161)2.82833964
87peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.82261606
88membrane depolarization during action potential (GO:0086010)2.81392715
89lymphangiogenesis (GO:0001946)2.81178436
90visual learning (GO:0008542)2.81058785
91mechanosensory behavior (GO:0007638)2.80989205
92regulation of dendritic spine development (GO:0060998)2.80122328
93auditory receptor cell stereocilium organization (GO:0060088)2.79021077
94* cyclic nucleotide catabolic process (GO:0009214)2.78979900
95cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.78959813
96response to gravity (GO:0009629)2.78933072
97* cAMP metabolic process (GO:0046058)2.78007286
98neuron cell-cell adhesion (GO:0007158)2.77659100
99dendrite morphogenesis (GO:0048813)2.76519506
100startle response (GO:0001964)2.76232976
101regulation of axon extension involved in axon guidance (GO:0048841)2.75896634
102membrane depolarization (GO:0051899)2.75217984
103glycine transport (GO:0015816)2.72412356
104cGMP metabolic process (GO:0046068)2.71168497
105L-amino acid import (GO:0043092)2.70864991
106visual behavior (GO:0007632)2.70496186
107behavioral response to nicotine (GO:0035095)2.69941843
108sodium ion export (GO:0071436)2.68949056
109presynaptic membrane organization (GO:0097090)2.68459173
110potassium ion import (GO:0010107)2.68162186
111righting reflex (GO:0060013)2.68154126
112long-term synaptic potentiation (GO:0060291)2.67154833
113cell communication by electrical coupling (GO:0010644)2.66728826
114regulation of cardiac muscle cell contraction (GO:0086004)2.66477196
115negative regulation of axon guidance (GO:1902668)2.65403967
116regulation of actin filament-based movement (GO:1903115)2.63829690
117platelet dense granule organization (GO:0060155)2.63587648
118positive regulation of cardiac muscle hypertrophy (GO:0010613)2.63337717
119positive regulation of muscle hypertrophy (GO:0014742)2.63337717
120peristalsis (GO:0030432)2.62433417
121negative regulation of dendrite development (GO:2000171)2.61817271
122dermatan sulfate metabolic process (GO:0030205)2.60835805
123sequestering of extracellular ligand from receptor (GO:0035581)2.60649968
124cAMP biosynthetic process (GO:0006171)2.60524841
125regulation of synaptic transmission, GABAergic (GO:0032228)2.58850215
126inner ear receptor stereocilium organization (GO:0060122)2.58088225
127postsynaptic membrane organization (GO:0001941)2.56620664
128blood vessel maturation (GO:0001955)2.55835371
129G-protein coupled receptor internalization (GO:0002031)2.55776986
130regulation of Rap GTPase activity (GO:0032317)2.55568875
131cardiac myofibril assembly (GO:0055003)2.55203320
132regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.53648510
133C4-dicarboxylate transport (GO:0015740)2.53527403
134interkinetic nuclear migration (GO:0022027)2.53292228
135positive regulation of heart rate (GO:0010460)2.50588409
136metanephric mesenchyme development (GO:0072075)2.49943583
137regulation of axon guidance (GO:1902667)2.48355112
138response to inactivity (GO:0014854)2.48184989
139regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.47518911
140regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.44503633
141detection of mechanical stimulus involved in sensory perception (GO:0050974)2.44488778
142kidney mesenchyme development (GO:0072074)2.43784971
143positive regulation of cardiac muscle cell differentiation (GO:2000727)2.43582688
144positive regulation of fatty acid transport (GO:2000193)2.42285404
145positive regulation of action potential (GO:0045760)2.41802631
146negative regulation of Rho protein signal transduction (GO:0035024)2.40342225
147L-fucose metabolic process (GO:0042354)2.40018921
148L-fucose catabolic process (GO:0042355)2.40018921
149fucose catabolic process (GO:0019317)2.40018921
150positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.39450095
151smooth muscle contraction (GO:0006939)2.38085869
152myofibril assembly (GO:0030239)2.37664124
153reflex (GO:0060004)2.36730658
154retina vasculature morphogenesis in camera-type eye (GO:0061299)2.35822700
155regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.34485944
156regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.33580037
157positive regulation of fatty acid oxidation (GO:0046321)2.32319628
158gamma-aminobutyric acid signaling pathway (GO:0007214)2.32254943
159positive regulation of meiosis (GO:0045836)2.30518696
160response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.29219440
161inositol phosphate-mediated signaling (GO:0048016)2.28467654
162glomerular basement membrane development (GO:0032836)2.28059594
163nonmotile primary cilium assembly (GO:0035058)2.25346205
164smooth muscle tissue development (GO:0048745)2.24716477
165mesenchymal-epithelial cell signaling (GO:0060638)2.24557934
166regulation of action potential (GO:0098900)2.24191798
167retinal cone cell development (GO:0046549)2.20209162
168sulfation (GO:0051923)2.18260503
169heparin metabolic process (GO:0030202)2.17673285
170heparin biosynthetic process (GO:0030210)2.17673285
171regulation of integrin-mediated signaling pathway (GO:2001044)2.17104584
172neuronal action potential (GO:0019228)2.16751244
173neuromuscular synaptic transmission (GO:0007274)2.15823388
174positive regulation of vascular permeability (GO:0043117)2.15121876
175cell migration involved in heart development (GO:0060973)2.14824108
176relaxation of cardiac muscle (GO:0055119)2.14441302
177regulation of sarcomere organization (GO:0060297)2.13959020
178tonic smooth muscle contraction (GO:0014820)2.13711743
179positive regulation of meiotic cell cycle (GO:0051446)2.13285367
180adrenergic receptor signaling pathway (GO:0071875)2.12965594
181chondrocyte proliferation (GO:0035988)2.10995490
182plasma membrane repair (GO:0001778)2.10991594
183positive regulation of icosanoid secretion (GO:0032305)2.09726138
184positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.09087432
185positive regulation of phosphatase activity (GO:0010922)2.08280574
186membrane assembly (GO:0071709)2.08098966
187response to pheromone (GO:0019236)2.07750136
188glomerular filtration (GO:0003094)2.07166189
189cGMP-mediated signaling (GO:0019934)2.06810221
190G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.06451559

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.39547830
2GBX2_23144817_ChIP-Seq_PC3_Human2.95369836
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74504551
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68631625
5* RARB_27405468_Chip-Seq_BRAIN_Mouse2.56954601
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.50091205
7DROSHA_22980978_ChIP-Seq_HELA_Human2.47305894
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42146364
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42146364
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35544842
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31610716
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29926152
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25200971
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23700430
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19807503
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.14546077
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12469640
18VDR_22108803_ChIP-Seq_LS180_Human2.08539776
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06157537
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02440829
21AR_21572438_ChIP-Seq_LNCaP_Human2.01552843
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.97846195
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.96157117
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92622746
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.89679649
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.88074031
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83536578
28* REST_21632747_ChIP-Seq_MESCs_Mouse1.79460657
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77453269
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75787925
31ZNF274_21170338_ChIP-Seq_K562_Hela1.74999265
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.74088619
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68215281
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.66818019
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60645708
36* CJUN_26792858_Chip-Seq_BT549_Human1.57935683
37* FUS_26573619_Chip-Seq_HEK293_Human1.55745635
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54419392
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54401512
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50471705
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.49859541
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47004958
43SMAD4_21799915_ChIP-Seq_A2780_Human1.45988028
44CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42985910
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.41750706
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39928106
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36831366
48* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36700954
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34806976
50* EZH2_27294783_Chip-Seq_NPCs_Mouse1.34382842
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33715819
52TAF15_26573619_Chip-Seq_HEK293_Human1.33133254
53ER_23166858_ChIP-Seq_MCF-7_Human1.31271574
54WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31074781
55* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29622179
56IGF1R_20145208_ChIP-Seq_DFB_Human1.29149809
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.27428059
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.26810691
59RXR_22108803_ChIP-Seq_LS180_Human1.26510196
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25326325
61EWS_26573619_Chip-Seq_HEK293_Human1.25072760
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.23638401
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23564929
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22792153
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21982685
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.20139311
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20080262
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19630834
69* GATA2_21666600_ChIP-Seq_HMVEC_Human1.19151435
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19145731
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17986116
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.17836572
73* STAT3_23295773_ChIP-Seq_U87_Human1.17657537
74P300_19829295_ChIP-Seq_ESCs_Human1.17530427
75SMAD3_21741376_ChIP-Seq_HESCs_Human1.17203694
76* FLI1_21867929_ChIP-Seq_TH2_Mouse1.16739140
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16333210
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.15908861
79AHR_22903824_ChIP-Seq_MCF-7_Human1.15587015
80* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15107181
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.14544483
82* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14232486
83AR_19668381_ChIP-Seq_PC3_Human1.14105030
84* PIAS1_25552417_ChIP-Seq_VCAP_Human1.12965343
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.12570402
86P53_22387025_ChIP-Seq_ESCs_Mouse1.12534519
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.12526925
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11780990
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10619270
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10124483
91TP53_16413492_ChIP-PET_HCT116_Human1.09810169
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08968060
93* EP300_21415370_ChIP-Seq_HL-1_Mouse1.08445399
94FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07488120
95CBP_20019798_ChIP-Seq_JUKART_Human1.07183001
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07183001
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.07073653
98* CRX_20693478_ChIP-Seq_RETINA_Mouse1.06768490
99RNF2_27304074_Chip-Seq_NSC_Mouse1.06688931
100KDM2B_26808549_Chip-Seq_K562_Human1.06328282
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06083716
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05994410
103GATA1_22025678_ChIP-Seq_K562_Human1.05912130
104KDM2B_26808549_Chip-Seq_REH_Human1.05422918
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.05320357
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05136381
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04686968
108* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04295751
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04081003
110* AR_25329375_ChIP-Seq_VCAP_Human1.04022867
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03518531
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03304001
113* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02732695
114* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02627271
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02094030
116TCF4_23295773_ChIP-Seq_U87_Human1.00849473
117* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99430755
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98906371
119CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98706429
120DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98019757
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.96752314
122TP53_18474530_ChIP-ChIP_U2OS_Human0.95382311
123BCAT_22108803_ChIP-Seq_LS180_Human0.95344078
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.94508171
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94373061
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94373061
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93809175
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93617412
129NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92373384
130RUNX2_22187159_ChIP-Seq_PCA_Human0.91748301
131* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91015460
132CBX2_27304074_Chip-Seq_ESCs_Mouse0.89006278
133RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87543114
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87405212
135EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85668744
136SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85540798
137TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85526801
138ESR2_21235772_ChIP-Seq_MCF-7_Human0.82892381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy7.18438049
2MP0004859_abnormal_synaptic_plasticity5.89700530
3MP0008438_abnormal_cutaneous_collagen4.00167175
4MP0003635_abnormal_synaptic_transmissio3.60340065
5MP0003880_abnormal_central_pattern3.53250414
6MP0009745_abnormal_behavioral_response3.28678631
7MP0005503_abnormal_tendon_morphology3.03187572
8MP0002063_abnormal_learning/memory/cond2.98194310
9MP0004270_analgesia2.83618526
10MP0002064_seizures2.67666143
11MP0001486_abnormal_startle_reflex2.56392038
12MP0005646_abnormal_pituitary_gland2.56334980
13MP0009046_muscle_twitch2.42298655
14MP0002572_abnormal_emotion/affect_behav2.38156322
15MP0003279_aneurysm2.33659725
16MP0001968_abnormal_touch/_nociception2.32249356
17MP0005275_abnormal_skin_tensile2.31520160
18MP0004272_abnormal_basement_membrane2.27813445
19MP0002909_abnormal_adrenal_gland2.26267347
20MP0006054_spinal_hemorrhage2.23050717
21MP0005409_darkened_coat_color2.18895618
22MP0001879_abnormal_lymphatic_vessel2.11682194
23MP0001984_abnormal_olfaction2.02320017
24MP0009384_cardiac_valve_regurgitation2.02171681
25MP0002272_abnormal_nervous_system2.01394161
26MP0001501_abnormal_sleep_pattern2.00375293
27MP0004858_abnormal_nervous_system1.84674909
28MP0003075_altered_response_to1.83718279
29MP0002734_abnormal_mechanical_nocicepti1.78330984
30MP0000751_myopathy1.75889434
31MP0008569_lethality_at_weaning1.74897623
32MP0002736_abnormal_nociception_after1.72195258
33MP0001529_abnormal_vocalization1.68176783
34MP0000569_abnormal_digit_pigmentation1.62639859
35MP0001440_abnormal_grooming_behavior1.59024418
36MP0005423_abnormal_somatic_nervous1.58550103
37MP0005551_abnormal_eye_electrophysiolog1.58339643
38MP0009780_abnormal_chondrocyte_physiolo1.54121838
39MP0003690_abnormal_glial_cell1.51967828
40MP0002108_abnormal_muscle_morphology1.50781341
41MP0003195_calcinosis1.50238332
42MP0004924_abnormal_behavior1.48443150
43MP0005386_behavior/neurological_phenoty1.48443150
44MP0005167_abnormal_blood-brain_barrier1.47068688
45MP0001970_abnormal_pain_threshold1.44859651
46MP0008961_abnormal_basal_metabolism1.44827801
47MP0001177_atelectasis1.43468025
48MP0001958_emphysema1.42866880
49MP0002067_abnormal_sensory_capabilities1.42771316
50MP0002557_abnormal_social/conspecific_i1.42259573
51MP0003633_abnormal_nervous_system1.39408921
52MP0002876_abnormal_thyroid_physiology1.38113215
53MP0003950_abnormal_plasma_membrane1.37190510
54MP0010386_abnormal_urinary_bladder1.37187443
55MP0001188_hyperpigmentation1.35645797
56MP0002295_abnormal_pulmonary_circulatio1.35012942
57MP0002733_abnormal_thermal_nociception1.34687486
58MP0002735_abnormal_chemical_nociception1.31289152
59MP0005595_abnormal_vascular_smooth1.29505207
60MP0004811_abnormal_neuron_physiology1.28076728
61MP0004130_abnormal_muscle_cell1.27806634
62MP0004085_abnormal_heartbeat1.26643934
63MP0002234_abnormal_pharynx_morphology1.26048995
64MP0002837_dystrophic_cardiac_calcinosis1.25132386
65MP0000230_abnormal_systemic_arterial1.24353828
66MP0009250_abnormal_appendicular_skeleto1.23493517
67MP0001502_abnormal_circadian_rhythm1.23307115
68MP0008874_decreased_physiological_sensi1.22096731
69MP0001661_extended_life_span1.21867890
70MP0006138_congestive_heart_failure1.21469625
71MP0003646_muscle_fatigue1.21337091
72MP0002168_other_aberrant_phenotype1.20609547
73MP0004215_abnormal_myocardial_fiber1.19477401
74MP0005623_abnormal_meninges_morphology1.15521541
75MP0001986_abnormal_taste_sensitivity1.14859153
76MP0004147_increased_porphyrin_level1.11827746
77MP0004036_abnormal_muscle_relaxation1.11506373
78MP0002102_abnormal_ear_morphology1.08038521
79MP0005166_decreased_susceptibility_to1.07477394
80MP0002066_abnormal_motor_capabilities/c1.06481674
81MP0004885_abnormal_endolymph1.06100598
82MP0000767_abnormal_smooth_muscle1.03763280
83MP0003631_nervous_system_phenotype1.01760169
84MP0000013_abnormal_adipose_tissue1.00449542
85MP0003879_abnormal_hair_cell0.99246854
86MP0003137_abnormal_impulse_conducting0.99091658
87MP0004145_abnormal_muscle_electrophysio0.98425107
88MP0000920_abnormal_myelination0.98108948
89MP0005369_muscle_phenotype0.97989360
90MP0001299_abnormal_eye_distance/0.97576364
91MP0008875_abnormal_xenobiotic_pharmacok0.96766825
92MP0005253_abnormal_eye_physiology0.96688611
93MP0005620_abnormal_muscle_contractility0.95628757
94MP0003045_fibrosis0.94099892
95MP0002090_abnormal_vision0.92736187
96MP0003329_amyloid_beta_deposits0.92116872
97MP0000427_abnormal_hair_cycle0.91350505
98MP0002184_abnormal_innervation0.90855350
99MP0005535_abnormal_body_temperature0.90722260
100MP0002882_abnormal_neuron_morphology0.90328072
101MP0000955_abnormal_spinal_cord0.89057072
102MP0000534_abnormal_ureter_morphology0.87917034
103MP0000778_abnormal_nervous_system0.86250953
104MP0002160_abnormal_reproductive_system0.85944460
105MP0003011_delayed_dark_adaptation0.85853479
106MP0002127_abnormal_cardiovascular_syste0.84286587
107MP0008872_abnormal_physiological_respon0.83931600
108MP0005187_abnormal_penis_morphology0.83927591
109MP0000538_abnormal_urinary_bladder0.82883156
110MP0006072_abnormal_retinal_apoptosis0.81966841
111MP0010234_abnormal_vibrissa_follicle0.81910738
112MP0000343_altered_response_to0.80902960
113MP0001544_abnormal_cardiovascular_syste0.80827639
114MP0005385_cardiovascular_system_phenoty0.80827639
115MP0004484_altered_response_of0.80417344
116MP0002269_muscular_atrophy0.78769946
117MP0002069_abnormal_eating/drinking_beha0.78559850
118MP0003136_yellow_coat_color0.78129652
119MP0003283_abnormal_digestive_organ0.77068652
120MP0000049_abnormal_middle_ear0.76046177
121MP0004084_abnormal_cardiac_muscle0.75830447
122MP0006276_abnormal_autonomic_nervous0.75502211
123MP0002972_abnormal_cardiac_muscle0.75339171
124MP0004087_abnormal_muscle_fiber0.74130594
125MP0004510_myositis0.72234292
126MP0005330_cardiomyopathy0.71078183
127MP0003634_abnormal_glial_cell0.70930932
128MP0000749_muscle_degeneration0.69801694
129MP0005171_absent_coat_pigmentation0.69273633
130MP0005248_abnormal_Harderian_gland0.67140129
131MP0003303_peritoneal_inflammation0.63582547
132MP0002152_abnormal_brain_morphology0.63399842
133MP0000604_amyloidosis0.62829164
134MP0008775_abnormal_heart_ventricle0.59837437
135MP0000747_muscle_weakness0.59814580
136MP0004142_abnormal_muscle_tone0.59578086
137MP0010368_abnormal_lymphatic_system0.58119850
138MP0000631_abnormal_neuroendocrine_gland0.57750703
139MP0002133_abnormal_respiratory_system0.57721926
140MP0005388_respiratory_system_phenotype0.57721926
141MP0001905_abnormal_dopamine_level0.55626342
142MP0005645_abnormal_hypothalamus_physiol0.55359171
143MP0002106_abnormal_muscle_physiology0.53786180
144MP0003787_abnormal_imprinting0.52480864

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.69538176
2Myokymia (HP:0002411)6.57743592
3Focal seizures (HP:0007359)5.12726355
4Febrile seizures (HP:0002373)4.05092219
5Keratoconus (HP:0000563)3.87422733
6Increased corneal curvature (HP:0100692)3.87422733
7Epileptic encephalopathy (HP:0200134)3.65158248
8Congenital sensorineural hearing impairment (HP:0008527)3.53182680
9Prolonged QT interval (HP:0001657)3.48921920
10Torticollis (HP:0000473)3.48693858
11Action tremor (HP:0002345)3.46855118
12Broad-based gait (HP:0002136)3.39678459
13Lower limb amyotrophy (HP:0007210)3.30302474
14Annular pancreas (HP:0001734)3.27840954
15Resting tremor (HP:0002322)3.23375175
16Poor eye contact (HP:0000817)3.22087453
17Broad metatarsal (HP:0001783)3.20748020
18Atonic seizures (HP:0010819)3.15372853
19Generalized tonic-clonic seizures (HP:0002069)3.11334691
20Distal lower limb amyotrophy (HP:0008944)3.08941256
21Absence seizures (HP:0002121)3.07998995
22Atrioventricular block (HP:0001678)3.06334638
23Short hallux (HP:0010109)3.05046760
24Atrial fibrillation (HP:0005110)3.01413236
25Impaired social interactions (HP:0000735)2.99386984
26Abnormal social behavior (HP:0012433)2.99386984
27Anxiety (HP:0000739)2.97243316
28Dialeptic seizures (HP:0011146)2.95489559
29Hypoplastic ischia (HP:0003175)2.94453735
30Exercise-induced myalgia (HP:0003738)2.91618855
31Focal dystonia (HP:0004373)2.89943893
32Abnormality of the ischium (HP:0003174)2.89855029
33Visual hallucinations (HP:0002367)2.88819629
34Primary atrial arrhythmia (HP:0001692)2.88715659
35Heart block (HP:0012722)2.85484390
36Craniofacial dystonia (HP:0012179)2.84209253
37Impaired vibration sensation in the lower limbs (HP:0002166)2.83703361
38Aplasia/Hypoplasia of the hallux (HP:0008362)2.81152999
39Abnormal EKG (HP:0003115)2.80620479
40Congenital, generalized hypertrichosis (HP:0004540)2.79681628
41Dysdiadochokinesis (HP:0002075)2.77493969
42Dysmetric saccades (HP:0000641)2.77421292
43Pancreatic fibrosis (HP:0100732)2.76925704
44Sudden death (HP:0001699)2.73456678
45Type II lissencephaly (HP:0007260)2.72691053
46Depression (HP:0000716)2.71221669
47Hyperventilation (HP:0002883)2.71042544
48Stereotypic behavior (HP:0000733)2.69467401
49Urinary bladder sphincter dysfunction (HP:0002839)2.68667741
50Abnormal atrioventricular conduction (HP:0005150)2.66165037
51Wrist flexion contracture (HP:0001239)2.65214714
52Supraventricular tachycardia (HP:0004755)2.65085808
53Molar tooth sign on MRI (HP:0002419)2.63066983
54Abnormality of midbrain morphology (HP:0002418)2.63066983
55Ankle clonus (HP:0011448)2.62603860
56Bundle branch block (HP:0011710)2.62556789
57Mitral stenosis (HP:0001718)2.60638158
58Supraventricular arrhythmia (HP:0005115)2.58695128
59Aortic aneurysm (HP:0004942)2.58388061
60Postural instability (HP:0002172)2.52795505
61Premature rupture of membranes (HP:0001788)2.51655891
62Aortic dissection (HP:0002647)2.51478632
63Protrusio acetabuli (HP:0003179)2.50064929
64Stomach cancer (HP:0012126)2.49252130
65Gaze-evoked nystagmus (HP:0000640)2.48115646
66Muscle fiber inclusion bodies (HP:0100299)2.47564230
67Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.45391529
68Nemaline bodies (HP:0003798)2.43682027
69Axonal loss (HP:0003447)2.42193757
70Polydipsia (HP:0001959)2.41453094
71Abnormal drinking behavior (HP:0030082)2.41453094
72Ventricular fibrillation (HP:0001663)2.40977081
73Pancreatic cysts (HP:0001737)2.39702586
74Large for gestational age (HP:0001520)2.37954868
75True hermaphroditism (HP:0010459)2.37040385
76Abnormal eating behavior (HP:0100738)2.36883582
77Round ear (HP:0100830)2.35248818
78Hyperlipoproteinemia (HP:0010980)2.32705946
79Ankyloglossia (HP:0010296)2.32311024
80Aplasia/Hypoplasia of the tibia (HP:0005772)2.32052997
81Chronic hepatic failure (HP:0100626)2.32040637
82Blue irides (HP:0000635)2.31601099
83Scanning speech (HP:0002168)2.29783816
84Chorioretinal atrophy (HP:0000533)2.27858071
85Dysmetria (HP:0001310)2.27541026
86Soft skin (HP:0000977)2.27447041
87Supranuclear gaze palsy (HP:0000605)2.27278196
88Congenital stationary night blindness (HP:0007642)2.27145284
89Pointed chin (HP:0000307)2.26131257
90Progressive cerebellar ataxia (HP:0002073)2.24167783
91Limited hip movement (HP:0008800)2.23100286
92Urinary urgency (HP:0000012)2.20476127
93Absent speech (HP:0001344)2.19934659
94Aplasia involving bones of the upper limbs (HP:0009823)2.18278267
95Aplasia of the phalanges of the hand (HP:0009802)2.18278267
96Aplasia involving bones of the extremities (HP:0009825)2.18278267
97Vascular tortuosity (HP:0004948)2.17945435
98Truncal ataxia (HP:0002078)2.16975723
99Status epilepticus (HP:0002133)2.14009276
100Short tibia (HP:0005736)2.13992788
101Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.13822923
102Hypothermia (HP:0002045)2.11825804
103Polygenic inheritance (HP:0010982)2.11734738
104Nephronophthisis (HP:0000090)2.11691939
105Overgrowth (HP:0001548)2.09895474
106Prominent supraorbital ridges (HP:0000336)2.09803668
107Intention tremor (HP:0002080)2.09264402
108Absent phalangeal crease (HP:0006109)2.09186413
109Syncope (HP:0001279)2.06465649
110Occipital encephalocele (HP:0002085)2.05778338
111Hip contracture (HP:0003273)2.04790797
112Difficulty running (HP:0009046)2.04692530
113Short chin (HP:0000331)2.03407578
114Ventricular arrhythmia (HP:0004308)2.03299316
115Abnormality of the renal medulla (HP:0100957)1.99349582
116Megalencephaly (HP:0001355)1.99198474
117Anterior segment dysgenesis (HP:0007700)1.98077102
118Hyperkalemia (HP:0002153)1.97909242
119Abnormality of the renal cortex (HP:0011035)1.97452435
120Furrowed tongue (HP:0000221)1.97026435
121Follicular hyperkeratosis (HP:0007502)1.96758543
122Palpebral edema (HP:0100540)1.95270015
123Abnormal finger flexion creases (HP:0006143)1.95110210
124Hemiplegia (HP:0002301)1.94889553
125Distal arthrogryposis (HP:0005684)1.94284034
126Bone cyst (HP:0012062)1.94263596
127Tubular atrophy (HP:0000092)1.93333271
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.91132856
129Mesomelia (HP:0003027)1.90976918
130Bulbous nose (HP:0000414)1.90821469
131Hypoplasia of the iris (HP:0007676)1.90332501
132Calf muscle hypertrophy (HP:0008981)1.90042280
133Impaired vibratory sensation (HP:0002495)1.89231466
134Polyuria (HP:0000103)1.89029412
135Obstructive sleep apnea (HP:0002870)1.88774932
136Subaortic stenosis (HP:0001682)1.88568913
137Abnormality of the left ventricular outflow tract (HP:0011103)1.88568913
138Mild short stature (HP:0003502)1.88405579
139Exercise-induced muscle cramps (HP:0003710)1.87480307
140Incomplete penetrance (HP:0003829)1.87147168
141Fetal akinesia sequence (HP:0001989)1.86809431
142Papilledema (HP:0001085)1.86738741
143Abnormality of the calf musculature (HP:0001430)1.86604692
144Hemiparesis (HP:0001269)1.86404471
145Onion bulb formation (HP:0003383)1.85727746
146Left ventricular hypertrophy (HP:0001712)1.85620252
147Abnormality of the periventricular white matter (HP:0002518)1.85569220
148Striae distensae (HP:0001065)1.84235010
149Arterial tortuosity (HP:0005116)1.84167788
150Ovoid vertebral bodies (HP:0003300)1.83749478
151Hematochezia (HP:0002573)1.82704097
152Metaphyseal dysplasia (HP:0100255)1.82668922
153Hypoplasia of the odontoid process (HP:0003311)1.80107023
154Decreased central vision (HP:0007663)1.79444250
155Fibular aplasia (HP:0002990)1.79070730
156Epileptiform EEG discharges (HP:0011182)1.78418056
157Muscle hypertrophy of the lower extremities (HP:0008968)1.76759967
158Medial flaring of the eyebrow (HP:0010747)1.75119744
159Fair hair (HP:0002286)1.74776044
160Deeply set eye (HP:0000490)1.74488187
161Neoplasm of the heart (HP:0100544)1.74035710
162Bradykinesia (HP:0002067)1.73879940
163EEG with generalized epileptiform discharges (HP:0011198)1.73663496
164Spinal canal stenosis (HP:0003416)1.73120273
165Progressive inability to walk (HP:0002505)1.72608197
166Neurofibrillary tangles (HP:0002185)1.72452817
167Lipoatrophy (HP:0100578)1.72192319
168Type 1 muscle fiber predominance (HP:0003803)1.71303873
169Excessive salivation (HP:0003781)1.70927134
170Drooling (HP:0002307)1.70927134
171Impaired smooth pursuit (HP:0007772)1.69027038
172Hypsarrhythmia (HP:0002521)1.68691914
173Lower limb muscle weakness (HP:0007340)1.64317483
174Turricephaly (HP:0000262)1.63391004
175Hyporeflexia of lower limbs (HP:0002600)1.60622954

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.32205664
2NTRK33.99019092
3PRKD33.83741585
4MAP4K22.66289503
5STK392.56695280
6DAPK22.54363878
7KSR22.51308126
8MAP3K92.50603507
9TNIK2.42038283
10RIPK42.32406646
11ADRBK22.30055182
12OXSR12.12207760
13CAMKK12.11086650
14FES2.00147842
15GRK11.83569154
16BMPR1B1.78650932
17MAP3K41.77497941
18KSR11.73720517
19PAK61.65658952
20MYLK1.62817556
21NTRK21.55160442
22SIK21.54185638
23MINK11.49052496
24PINK11.48215326
25TRPM71.44908862
26MAPK131.43435638
27ADRBK11.41928015
28PRKCH1.41772578
29MAP3K131.40637582
30MAP2K71.39069267
31NTRK11.38855215
32MARK31.38273990
33SGK21.36734343
34CDK51.34761942
35SGK31.32957162
36TLK11.32480813
37MAP3K121.29990489
38AKT31.26894711
39CASK1.26742090
40CAMKK21.25760313
41DMPK1.22679848
42LMTK21.21613717
43PRPF4B1.21257704
44MAP2K41.20756874
45DDR21.20280101
46FER1.18904806
47MAP3K21.17939374
48SGK2231.17460462
49SGK4941.17460462
50WNK41.16739248
51STK381.16302780
52TGFBR11.10764035
53TGFBR21.07869054
54MARK11.07543484
55RIPK11.07138077
56TAOK11.05676245
57PHKG11.03390460
58PHKG21.03390460
59MARK21.01263358
60DAPK10.98191938
61WNK10.95906376
62MAPK150.95054292
63NLK0.94014953
64SGK10.93895015
65TYRO30.91590884
66ACVR1B0.91050922
67BMPR20.91019961
68RAF10.89770176
69PNCK0.89006158
70ARAF0.87618930
71STK110.86784769
72CAMK10.86645258
73EPHA30.86493257
74MAPK120.84789063
75LATS10.83411121
76PIK3CA0.78443026
77NUAK10.78020612
78PDK20.75314997
79MAP2K10.75310576
80ERBB40.75137012
81PDPK10.74839057
82PAK30.74534926
83NEK60.73110172
84MAP3K10.72184607
85PDGFRB0.71692790
86PRKCG0.70956544
87PIK3CG0.70174470
88CAMK2A0.70087320
89PRKD20.69001015
90RET0.68893589
91SIK30.68742704
92NEK90.68581734
93CAMK40.67542163
94PTK2B0.67078517
95ERBB30.65344400
96TXK0.63691889
97PRKCE0.63091748
98ABL20.62383325
99MAPKAPK50.61517900
100PDK10.61182749
101RPS6KA30.60931566
102TRIB30.60391215
103WNK30.59344832
104FGFR20.59160270
105PRKD10.58846586
106OBSCN0.58730568
107LIMK10.57586563
108MAP3K70.57438355
109PRKG10.56977664
110DYRK1A0.55134128
111CAMK2G0.55076377
112FGFR10.54541851
113FYN0.53742196
114PKN10.52997103
115JAK10.52518214
116TAOK20.52494611
117TTN0.52145305
118CAMK1G0.51814903
119PRKCZ0.51536674
120CAMK2B0.50806314
121PLK20.50670977
122CSNK1G10.50207648
123PRKAA20.49936166
124GRK70.49703620
125ABL10.49465921
126GSK3A0.49439314
127PDGFRA0.48683236
128FRK0.48323567
129PAK20.48002944
130MAPKAPK30.47882881
131KIT0.47478185
132MAPK70.46028447
133CAMK2D0.45473924
134TIE10.44748251
135IGF1R0.44114097
136STK30.44025333
137CDC42BPA0.43059593
138MUSK0.43034754
139PRKCA0.42573160
140CDK180.42146089
141CDK150.40761960
142TEC0.38897347
143CDK140.38679646
144ALK0.35578662
145ROCK10.35560778
146MAPK100.34670594
147HCK0.34425982
148SIK10.34303247
149PRKACG0.33760318
150GRK50.33303050
151INSRR0.32689728
152PRKACA0.32556274
153NEK10.32086635

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.79934123
2Olfactory transduction_Homo sapiens_hsa047403.24614159
3Circadian entrainment_Homo sapiens_hsa047132.46557388
4Nicotine addiction_Homo sapiens_hsa050332.31123400
5* Morphine addiction_Homo sapiens_hsa050322.25847624
6Amphetamine addiction_Homo sapiens_hsa050312.20801120
7GABAergic synapse_Homo sapiens_hsa047272.19030685
8Long-term potentiation_Homo sapiens_hsa047202.10909282
9Glutamatergic synapse_Homo sapiens_hsa047242.10157551
10Cocaine addiction_Homo sapiens_hsa050302.05753345
11Synaptic vesicle cycle_Homo sapiens_hsa047211.98261360
12ECM-receptor interaction_Homo sapiens_hsa045121.96756887
13Linoleic acid metabolism_Homo sapiens_hsa005911.96337281
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93903308
15Dopaminergic synapse_Homo sapiens_hsa047281.88193920
16Cholinergic synapse_Homo sapiens_hsa047251.86211549
17Caffeine metabolism_Homo sapiens_hsa002321.85654355
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81396439
19Renin secretion_Homo sapiens_hsa049241.79003622
20Salivary secretion_Homo sapiens_hsa049701.77466416
21Insulin secretion_Homo sapiens_hsa049111.73570367
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62577195
23Calcium signaling pathway_Homo sapiens_hsa040201.62317009
24Gastric acid secretion_Homo sapiens_hsa049711.60072553
25ABC transporters_Homo sapiens_hsa020101.57327056
26Oxytocin signaling pathway_Homo sapiens_hsa049211.55963665
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46948422
28Tryptophan metabolism_Homo sapiens_hsa003801.35749267
29cAMP signaling pathway_Homo sapiens_hsa040241.34590069
30Dilated cardiomyopathy_Homo sapiens_hsa054141.32447395
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32371529
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30264755
33GnRH signaling pathway_Homo sapiens_hsa049121.28469774
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24396032
35Gap junction_Homo sapiens_hsa045401.22863555
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22590394
37Serotonergic synapse_Homo sapiens_hsa047261.22438801
38Ether lipid metabolism_Homo sapiens_hsa005651.22082434
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19863065
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19357063
41Long-term depression_Homo sapiens_hsa047301.17256552
42Taste transduction_Homo sapiens_hsa047421.14430020
43Type II diabetes mellitus_Homo sapiens_hsa049301.09501423
44Chemical carcinogenesis_Homo sapiens_hsa052041.07927257
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06836695
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06663007
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.06115300
48Arginine biosynthesis_Homo sapiens_hsa002201.06046885
49Protein digestion and absorption_Homo sapiens_hsa049741.04207206
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03499612
51Glioma_Homo sapiens_hsa052141.00755743
52Retinol metabolism_Homo sapiens_hsa008300.94930918
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94149544
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93842132
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.93489450
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91880345
57Dorso-ventral axis formation_Homo sapiens_hsa043200.91306183
58Sulfur relay system_Homo sapiens_hsa041220.90180377
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.90153476
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88822052
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88249805
62Melanogenesis_Homo sapiens_hsa049160.87178639
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.87020957
64Estrogen signaling pathway_Homo sapiens_hsa049150.86694023
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85687921
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84865674
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83606647
68Arachidonic acid metabolism_Homo sapiens_hsa005900.83493862
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82698303
70Propanoate metabolism_Homo sapiens_hsa006400.81524854
71Cardiac muscle contraction_Homo sapiens_hsa042600.79393652
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78554145
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77395670
74Histidine metabolism_Homo sapiens_hsa003400.77392577
75ErbB signaling pathway_Homo sapiens_hsa040120.77390257
76Mineral absorption_Homo sapiens_hsa049780.76226809
77Axon guidance_Homo sapiens_hsa043600.76098773
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76000526
79Bile secretion_Homo sapiens_hsa049760.75218111
80Glucagon signaling pathway_Homo sapiens_hsa049220.74347071
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73789749
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73636364
83Fatty acid biosynthesis_Homo sapiens_hsa000610.72624998
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72538853
85Rap1 signaling pathway_Homo sapiens_hsa040150.72208037
86African trypanosomiasis_Homo sapiens_hsa051430.71467227
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67128572
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66207734
89Thyroid hormone synthesis_Homo sapiens_hsa049180.65961285
90Pancreatic secretion_Homo sapiens_hsa049720.65758638
91TGF-beta signaling pathway_Homo sapiens_hsa043500.65076049
92Circadian rhythm_Homo sapiens_hsa047100.64783796
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64264673
94Complement and coagulation cascades_Homo sapiens_hsa046100.62288890
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.61423218
96beta-Alanine metabolism_Homo sapiens_hsa004100.58940002
97Choline metabolism in cancer_Homo sapiens_hsa052310.58517504
98Tight junction_Homo sapiens_hsa045300.57822748
99MAPK signaling pathway_Homo sapiens_hsa040100.56696203
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.56441729
101Inositol phosphate metabolism_Homo sapiens_hsa005620.56142610
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55429572
103Collecting duct acid secretion_Homo sapiens_hsa049660.54254321
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53341715
105Insulin signaling pathway_Homo sapiens_hsa049100.53032533
106Chemokine signaling pathway_Homo sapiens_hsa040620.52899686
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51533385
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51047251
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50812011
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50365040
111Sphingolipid metabolism_Homo sapiens_hsa006000.47983915
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47010379
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.46277095
114Hippo signaling pathway_Homo sapiens_hsa043900.45948523
115Non-small cell lung cancer_Homo sapiens_hsa052230.45535976
116Prion diseases_Homo sapiens_hsa050200.45410852
117Ras signaling pathway_Homo sapiens_hsa040140.45164279
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.44733319
119Phototransduction_Homo sapiens_hsa047440.44732399
120VEGF signaling pathway_Homo sapiens_hsa043700.44025735
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43813746
122mTOR signaling pathway_Homo sapiens_hsa041500.42612071
123Fatty acid degradation_Homo sapiens_hsa000710.42241496
124Platelet activation_Homo sapiens_hsa046110.40720883
125Hedgehog signaling pathway_Homo sapiens_hsa043400.40192547
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.39300747
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39198104
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39032129
129Ovarian steroidogenesis_Homo sapiens_hsa049130.38531641
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38501673
131Arginine and proline metabolism_Homo sapiens_hsa003300.37851971
132Butanoate metabolism_Homo sapiens_hsa006500.37744966
133Insulin resistance_Homo sapiens_hsa049310.37509114
134Endometrial cancer_Homo sapiens_hsa052130.37254461
135Melanoma_Homo sapiens_hsa052180.37251747
136Renal cell carcinoma_Homo sapiens_hsa052110.36671397
137Amoebiasis_Homo sapiens_hsa051460.35216794
138PPAR signaling pathway_Homo sapiens_hsa033200.33887702
139Type I diabetes mellitus_Homo sapiens_hsa049400.33520741
140Alcoholism_Homo sapiens_hsa050340.33454470
141Focal adhesion_Homo sapiens_hsa045100.30429762

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