PDE8B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.87533200
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.68369033
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.39802093
4retinal cone cell development (GO:0046549)5.33110878
5locomotory exploration behavior (GO:0035641)5.30777499
6vocalization behavior (GO:0071625)5.23661378
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.22798970
8neurotransmitter-gated ion channel clustering (GO:0072578)5.14493854
9synaptic vesicle maturation (GO:0016188)4.96004046
10regulation of glutamate receptor signaling pathway (GO:1900449)4.92383166
11synaptic vesicle exocytosis (GO:0016079)4.87508457
12protein localization to synapse (GO:0035418)4.83888030
13regulation of acrosome reaction (GO:0060046)4.77161782
14glutamate secretion (GO:0014047)4.77123139
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.73769795
16regulation of synaptic vesicle exocytosis (GO:2000300)4.67139031
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.64542749
18regulation of female gonad development (GO:2000194)4.53448389
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.52259213
20neuron cell-cell adhesion (GO:0007158)4.38514810
21regulation of synaptic vesicle transport (GO:1902803)4.17800224
22synaptic transmission, glutamatergic (GO:0035249)4.17791485
23regulation of neuronal synaptic plasticity (GO:0048168)4.17592111
24glutamate receptor signaling pathway (GO:0007215)4.16305262
25neuron-neuron synaptic transmission (GO:0007270)4.10657083
26neuronal action potential propagation (GO:0019227)4.09452574
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.08781511
28neurotransmitter secretion (GO:0007269)4.06870703
29regulation of DNA methylation (GO:0044030)4.03086192
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.00073548
31regulation of excitatory postsynaptic membrane potential (GO:0060079)3.95910941
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.94099177
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.92924564
34regulation of meiosis I (GO:0060631)3.89557237
35exploration behavior (GO:0035640)3.88449491
36positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.87781406
37piRNA metabolic process (GO:0034587)3.86008312
38cellular potassium ion homeostasis (GO:0030007)3.82959099
39long-term memory (GO:0007616)3.80377117
40regulation of synapse structural plasticity (GO:0051823)3.78900491
41regulation of postsynaptic membrane potential (GO:0060078)3.78832516
42regulation of calcium ion-dependent exocytosis (GO:0017158)3.78231466
43positive regulation of membrane potential (GO:0045838)3.77899373
44positive regulation of neurotransmitter secretion (GO:0001956)3.77853827
45long-term synaptic potentiation (GO:0060291)3.77073597
46response to histamine (GO:0034776)3.76226756
47positive regulation of neurotransmitter transport (GO:0051590)3.75785953
48meiotic cell cycle (GO:0051321)3.74840906
49presynaptic membrane assembly (GO:0097105)3.69138348
50regulation of synaptic transmission, glutamatergic (GO:0051966)3.69104916
51gamma-aminobutyric acid signaling pathway (GO:0007214)3.67165948
52gamma-aminobutyric acid transport (GO:0015812)3.64213036
53positive regulation of meiosis (GO:0045836)3.64092002
54regulation of synaptic plasticity (GO:0048167)3.62895994
55amino acid import (GO:0043090)3.60538796
56potassium ion import (GO:0010107)3.53698910
57negative regulation of cytosolic calcium ion concentration (GO:0051481)3.52177612
58regulation of female receptivity (GO:0045924)3.48574819
59thyroid hormone generation (GO:0006590)3.48246536
60positive regulation of synaptic transmission, GABAergic (GO:0032230)3.47904648
61thyroid hormone metabolic process (GO:0042403)3.47032509
62regulation of dendritic spine morphogenesis (GO:0061001)3.46856671
63glycine transport (GO:0015816)3.45233364
64postsynaptic membrane organization (GO:0001941)3.45041461
65presynaptic membrane organization (GO:0097090)3.42488195
66multicellular organism reproduction (GO:0032504)3.41006854
67positive regulation of synapse maturation (GO:0090129)3.39350826
68dendritic spine morphogenesis (GO:0060997)3.37690617
69neurotransmitter transport (GO:0006836)3.37344402
70positive regulation of meiotic cell cycle (GO:0051446)3.37192378
71transmission of nerve impulse (GO:0019226)3.36792982
72relaxation of smooth muscle (GO:0044557)3.35762457
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.34289392
74auditory behavior (GO:0031223)3.32314918
75response to auditory stimulus (GO:0010996)3.31781552
76regulation of neurotransmitter secretion (GO:0046928)3.31171903
77oocyte development (GO:0048599)3.29783941
78neuron recognition (GO:0008038)3.29460501
79behavioral defense response (GO:0002209)3.29206594
80behavioral fear response (GO:0001662)3.29206594
81female mating behavior (GO:0060180)3.26101520
82cochlea development (GO:0090102)3.24405614
83positive regulation of synaptic transmission (GO:0050806)3.23714255
84regulation of glutamate secretion (GO:0014048)3.23003648
85membrane hyperpolarization (GO:0060081)3.22083030
86DNA methylation involved in gamete generation (GO:0043046)3.20072291
87layer formation in cerebral cortex (GO:0021819)3.19747599
88proline transport (GO:0015824)3.19294464
89neuromuscular process controlling balance (GO:0050885)3.17759508
90regulation of steroid hormone secretion (GO:2000831)3.14194363
91striatum development (GO:0021756)3.14110171
92regulation of voltage-gated calcium channel activity (GO:1901385)3.13896413
93membrane depolarization (GO:0051899)3.13266607
94behavioral response to cocaine (GO:0048148)3.12865707
95righting reflex (GO:0060013)3.10832133
96negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10734468
97L-amino acid import (GO:0043092)3.10504102
98G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.10412813
99activation of protein kinase A activity (GO:0034199)3.09766595
100regulation of neurotransmitter transport (GO:0051588)3.09752836
101regulation of neurotransmitter levels (GO:0001505)3.06546060
102fear response (GO:0042596)3.06208739
103positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.05636193
104startle response (GO:0001964)3.05031679
105regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04873263
106cerebellar Purkinje cell differentiation (GO:0021702)3.04743992
107learning (GO:0007612)3.04471773
108regulation of vesicle fusion (GO:0031338)3.04380364
109synaptic vesicle endocytosis (GO:0048488)3.03789391
110cellular sodium ion homeostasis (GO:0006883)3.03222854
111sodium ion export (GO:0071436)3.02987757
112prepulse inhibition (GO:0060134)3.02632002
113regulation of dendritic spine development (GO:0060998)3.01663901
114synaptic transmission, dopaminergic (GO:0001963)3.00639781
115regulation of synaptic transmission (GO:0050804)3.00572999
116regulation of synaptic transmission, GABAergic (GO:0032228)2.99467730
117cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99361255
118calcium ion-dependent exocytosis (GO:0017156)2.97060709
119negative regulation of amino acid transport (GO:0051956)2.94306864
120regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93565376
121synaptic transmission (GO:0007268)2.92782367
122membrane depolarization during action potential (GO:0086010)2.91980044
123dopamine biosynthetic process (GO:0042416)2.91105563
124positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90858185
125mechanosensory behavior (GO:0007638)2.90812138
126female gamete generation (GO:0007292)2.90475151
127chemosensory behavior (GO:0007635)2.87326736
128long term synaptic depression (GO:0060292)2.85583514
129visual learning (GO:0008542)2.84891393
130regulation of meiosis (GO:0040020)2.83544771
131potassium ion homeostasis (GO:0055075)2.79033713
132positive regulation of histone H3-K4 methylation (GO:0051571)2.77783701
133negative regulation of reproductive process (GO:2000242)2.72780328
134relaxation of cardiac muscle (GO:0055119)2.70740487
135regulation of cell maturation (GO:1903429)2.70265362
136detection of calcium ion (GO:0005513)2.69350060
137cAMP-mediated signaling (GO:0019933)2.61817615
138type B pancreatic cell development (GO:0003323)2.55094363
139potassium ion transmembrane transport (GO:0071805)2.52911246
140cellular potassium ion transport (GO:0071804)2.52911246
141axon ensheathment in central nervous system (GO:0032291)2.51933941
142central nervous system myelination (GO:0022010)2.51933941
143insulin secretion (GO:0030073)2.46123401
144* phosphorelay signal transduction system (GO:0000160)2.42361140
145regulation of exocytosis (GO:0017157)2.40638536
146adult walking behavior (GO:0007628)2.40038094
147aggressive behavior (GO:0002118)2.39900856
148negative regulation of cAMP-mediated signaling (GO:0043951)2.39202533
149sleep (GO:0030431)2.38049231
150positive regulation of dendritic spine development (GO:0060999)2.37509169
151potassium ion transport (GO:0006813)2.37289261
152cerebellar granule cell differentiation (GO:0021707)2.36496357
153regulation of meiotic cell cycle (GO:0051445)2.36380075
154serotonin metabolic process (GO:0042428)2.35206730
155phospholipid dephosphorylation (GO:0046839)2.34770259
156positive regulation of exocytosis (GO:0045921)2.33790874
157positive regulation of gastrulation (GO:2000543)2.31854759

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.28592532
2GBX2_23144817_ChIP-Seq_PC3_Human3.94547394
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11174691
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06562575
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98628053
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91304631
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.66599311
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64129363
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61373428
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61373428
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57337006
12* RARB_27405468_Chip-Seq_BRAIN_Mouse2.53734800
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52001929
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49384294
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47405345
16REST_21632747_ChIP-Seq_MESCs_Mouse2.46134876
17DROSHA_22980978_ChIP-Seq_HELA_Human2.43228510
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43126294
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.40372894
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.34223902
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13578626
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.10570076
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.10108651
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.10032783
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94890264
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.94735750
27AR_21572438_ChIP-Seq_LNCaP_Human1.92965667
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85834465
29TAF15_26573619_Chip-Seq_HEK293_Human1.81638672
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79210460
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78173668
32SMAD4_21799915_ChIP-Seq_A2780_Human1.77196761
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76956064
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68827749
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64530883
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63716011
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.60450453
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55281092
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.54403667
40P300_19829295_ChIP-Seq_ESCs_Human1.54361762
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52068186
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50784129
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.44201527
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43896557
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41982494
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41315483
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.38098915
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37530729
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35730615
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.35651501
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.34045928
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32046306
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31425021
54* AR_25329375_ChIP-Seq_VCAP_Human1.31299256
55* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30754345
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30540012
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28173992
58* STAT3_23295773_ChIP-Seq_U87_Human1.27904340
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27026260
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26887320
61* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23762266
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23402130
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23054549
64* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22882193
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22663437
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22544904
67* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22465985
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.21839049
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20926571
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20926571
71* ARNT_22903824_ChIP-Seq_MCF-7_Human1.19902746
72AR_19668381_ChIP-Seq_PC3_Human1.18606559
73* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16747302
74* AHR_22903824_ChIP-Seq_MCF-7_Human1.16677100
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15294841
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14756093
77* TCF4_23295773_ChIP-Seq_U87_Human1.14743502
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14490279
79CBP_20019798_ChIP-Seq_JUKART_Human1.13882900
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13882900
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13382104
82CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12513829
83* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09447047
84TP53_16413492_ChIP-PET_HCT116_Human1.09131706
85RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08097713
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.07836997
87RNF2_27304074_Chip-Seq_NSC_Mouse1.07116914
88ZNF274_21170338_ChIP-Seq_K562_Hela1.06998795
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06341079
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.06026939
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05529058
92SMAD3_21741376_ChIP-Seq_HESCs_Human1.04833625
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04063943
94* RUNX2_22187159_ChIP-Seq_PCA_Human1.03075940
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02593299
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02111630
97FUS_26573619_Chip-Seq_HEK293_Human1.01727506
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.00357953
99ER_23166858_ChIP-Seq_MCF-7_Human0.99263609
100RXR_22108803_ChIP-Seq_LS180_Human0.98967279
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98192983
102BCAT_22108803_ChIP-Seq_LS180_Human0.97439543
103TCF4_22108803_ChIP-Seq_LS180_Human0.97105522
104TP53_18474530_ChIP-ChIP_U2OS_Human0.96936399
105IGF1R_20145208_ChIP-Seq_DFB_Human0.96871119
106* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96870553
107SALL1_21062744_ChIP-ChIP_HESCs_Human0.95583726
108DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95516725
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93945498
110SMAD3_21741376_ChIP-Seq_ESCs_Human0.93817866
111VDR_22108803_ChIP-Seq_LS180_Human0.93220421
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93100153
113* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93036417
114TAL1_26923725_Chip-Seq_HPCs_Mouse0.92668737
115* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92576820
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92525850
117* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92437673
118JUN_21703547_ChIP-Seq_K562_Human0.92363871
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.91975888
120NANOG_18555785_Chip-Seq_ESCs_Mouse0.91369735
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90846229
122EWS_26573619_Chip-Seq_HEK293_Human0.90738398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.13564454
2MP0003880_abnormal_central_pattern5.70508776
3MP0003635_abnormal_synaptic_transmissio4.05005753
4MP0002822_catalepsy3.61698178
5MP0009745_abnormal_behavioral_response3.56245292
6MP0004270_analgesia3.34918363
7MP0002063_abnormal_learning/memory/cond3.30537668
8MP0002064_seizures3.21345258
9MP0001968_abnormal_touch/_nociception3.10257506
10MP0009046_muscle_twitch3.00400965
11MP0008877_abnormal_DNA_methylation2.89214548
12MP0003718_maternal_effect2.86899931
13MP0002572_abnormal_emotion/affect_behav2.85410013
14MP0005423_abnormal_somatic_nervous2.82338306
15MP0001486_abnormal_startle_reflex2.67809024
16MP0002272_abnormal_nervous_system2.61573459
17MP0002736_abnormal_nociception_after2.42608995
18MP0002734_abnormal_mechanical_nocicepti2.36104648
19MP0001501_abnormal_sleep_pattern2.35555917
20MP0009780_abnormal_chondrocyte_physiolo2.33696351
21MP0005551_abnormal_eye_electrophysiolog2.23238677
22MP0001440_abnormal_grooming_behavior2.11402740
23MP0005646_abnormal_pituitary_gland2.02282313
24MP0002735_abnormal_chemical_nociception1.98410984
25MP0002067_abnormal_sensory_capabilities1.89881772
26MP0001970_abnormal_pain_threshold1.78666004
27MP0003879_abnormal_hair_cell1.73755478
28MP0002733_abnormal_thermal_nociception1.72267185
29MP0001984_abnormal_olfaction1.72097407
30MP0002557_abnormal_social/conspecific_i1.69697646
31MP0010234_abnormal_vibrissa_follicle1.66792610
32MP0008569_lethality_at_weaning1.65842430
33MP0004924_abnormal_behavior1.61774815
34MP0005386_behavior/neurological_phenoty1.61774815
35MP0003890_abnormal_embryonic-extraembry1.58561725
36MP0003329_amyloid_beta_deposits1.55607526
37MP0003787_abnormal_imprinting1.55315035
38MP0002909_abnormal_adrenal_gland1.53900614
39MP0001502_abnormal_circadian_rhythm1.50981919
40MP0000778_abnormal_nervous_system1.47185233
41MP0004811_abnormal_neuron_physiology1.46119324
42MP0001529_abnormal_vocalization1.43281629
43MP0002184_abnormal_innervation1.43050708
44MP0003633_abnormal_nervous_system1.39436928
45MP0002882_abnormal_neuron_morphology1.37996099
46MP0005395_other_phenotype1.36298545
47MP0001188_hyperpigmentation1.35817202
48MP0006292_abnormal_olfactory_placode1.30980312
49MP0004858_abnormal_nervous_system1.30960411
50MP0002066_abnormal_motor_capabilities/c1.28241475
51MP0004885_abnormal_endolymph1.28203979
52MP0008789_abnormal_olfactory_epithelium1.28065181
53MP0006276_abnormal_autonomic_nervous1.28038337
54MP0000955_abnormal_spinal_cord1.26290878
55MP0002234_abnormal_pharynx_morphology1.21271029
56MP0002090_abnormal_vision1.19688992
57MP0003121_genomic_imprinting1.18309215
58MP0001944_abnormal_pancreas_morphology1.16772509
59MP0005253_abnormal_eye_physiology1.16760100
60MP0004142_abnormal_muscle_tone1.16346489
61MP0003136_yellow_coat_color1.16191783
62MP0006072_abnormal_retinal_apoptosis1.14679754
63MP0010386_abnormal_urinary_bladder1.13219108
64MP0001986_abnormal_taste_sensitivity1.12815665
65MP0002229_neurodegeneration1.12487173
66MP0000566_synostosis1.12281933
67MP0003631_nervous_system_phenotype1.10916146
68MP0000681_abnormal_thyroid_gland1.10391500
69MP0010678_abnormal_skin_adnexa1.08968020
70MP0005645_abnormal_hypothalamus_physiol1.07545927
71MP0001905_abnormal_dopamine_level1.04352605
72MP0008057_abnormal_DNA_replication1.03404141
73MP0003122_maternal_imprinting1.00443260
74MP0001929_abnormal_gametogenesis1.00253703
75MP0001177_atelectasis0.98767699
76MP0003699_abnormal_female_reproductive0.97199781
77MP0000751_myopathy0.96473447
78MP0005167_abnormal_blood-brain_barrier0.95260315
79MP0000427_abnormal_hair_cycle0.95144959
80MP0003075_altered_response_to0.95119024
81MP0004085_abnormal_heartbeat0.94518571
82MP0003690_abnormal_glial_cell0.94204092
83MP0004742_abnormal_vestibular_system0.93356989
84MP0002152_abnormal_brain_morphology0.92699581
85MP0008872_abnormal_physiological_respon0.92674417
86MP0002160_abnormal_reproductive_system0.90579103
87MP0000013_abnormal_adipose_tissue0.89796262
88MP0002069_abnormal_eating/drinking_beha0.89485919
89MP0004215_abnormal_myocardial_fiber0.89151523
90MP0008874_decreased_physiological_sensi0.89133553
91MP0005379_endocrine/exocrine_gland_phen0.88740189
92MP0002210_abnormal_sex_determination0.88387983
93MP0000026_abnormal_inner_ear0.85803345
94MP0001963_abnormal_hearing_physiology0.84613311
95MP0002161_abnormal_fertility/fecundity0.83736802
96MP0002876_abnormal_thyroid_physiology0.83545299
97MP0002752_abnormal_somatic_nervous0.83332737
98MP0003195_calcinosis0.82017071
99MP0004484_altered_response_of0.81832275
100MP0005171_absent_coat_pigmentation0.79714104
101MP0005623_abnormal_meninges_morphology0.79681063
102MP0002928_abnormal_bile_duct0.79576738
103MP0003634_abnormal_glial_cell0.79561670
104MP0005410_abnormal_fertilization0.78989630
105MP0003698_abnormal_male_reproductive0.78585529
106MP0000383_abnormal_hair_follicle0.78317583
107MP0002638_abnormal_pupillary_reflex0.78175577
108MP0004145_abnormal_muscle_electrophysio0.75733243
109MP0001664_abnormal_digestion0.74969141
110MP0000653_abnormal_sex_gland0.74903191
111MP0000631_abnormal_neuroendocrine_gland0.73462757
112MP0003953_abnormal_hormone_level0.72782110
113MP0005409_darkened_coat_color0.72771864
114MP0005535_abnormal_body_temperature0.72147111
115MP0005195_abnormal_posterior_eye0.70889944
116MP0000569_abnormal_digit_pigmentation0.66600056
117MP0003632_abnormal_nervous_system0.65958626
118MP0000920_abnormal_myelination0.63746936
119MP0001485_abnormal_pinna_reflex0.63663507
120MP0002837_dystrophic_cardiac_calcinosis0.63501000
121MP0000604_amyloidosis0.62422013
122MP0005499_abnormal_olfactory_system0.60163695
123MP0005394_taste/olfaction_phenotype0.60163695
124MP0008961_abnormal_basal_metabolism0.58818613
125MP0005595_abnormal_vascular_smooth0.57327883
126MP0004233_abnormal_muscle_weight0.57059871
127MP0003137_abnormal_impulse_conducting0.56158094
128MP0003183_abnormal_peptide_metabolism0.55648522
129MP0004043_abnormal_pH_regulation0.54751436
130MP0001943_abnormal_respiration0.54542931
131MP0003283_abnormal_digestive_organ0.54489837

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.65669506
2Myokymia (HP:0002411)6.33750853
3Focal seizures (HP:0007359)5.87414168
4Epileptic encephalopathy (HP:0200134)5.68865329
5Atonic seizures (HP:0010819)5.09127284
6Febrile seizures (HP:0002373)4.86111567
7Absence seizures (HP:0002121)4.51772841
8Visual hallucinations (HP:0002367)4.48780470
9Dialeptic seizures (HP:0011146)4.22879078
10Increased circulating renin level (HP:0000848)4.12700490
11Hyperventilation (HP:0002883)4.12548807
12Generalized tonic-clonic seizures (HP:0002069)4.09369960
13Progressive cerebellar ataxia (HP:0002073)3.94593178
14Congenital sensorineural hearing impairment (HP:0008527)3.77313820
15Broad-based gait (HP:0002136)3.66464783
16Gaze-evoked nystagmus (HP:0000640)3.56995473
17Limb dystonia (HP:0002451)3.45922214
18Thyroid-stimulating hormone excess (HP:0002925)3.34213612
19Action tremor (HP:0002345)3.33504522
20Goiter (HP:0000853)3.31092780
21Congenital stationary night blindness (HP:0007642)3.27168789
22Poor eye contact (HP:0000817)3.19155093
23Truncal ataxia (HP:0002078)3.05991785
24Amblyopia (HP:0000646)3.03302028
25Supranuclear gaze palsy (HP:0000605)3.02620203
26Depression (HP:0000716)3.02226881
27Oligodactyly (hands) (HP:0001180)2.98367430
28Anxiety (HP:0000739)2.98015178
29Abnormality of abdominal situs (HP:0011620)2.97256793
30Abdominal situs inversus (HP:0003363)2.97256793
31Impaired vibration sensation in the lower limbs (HP:0002166)2.95074688
32* Dysdiadochokinesis (HP:0002075)2.91564437
33Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.91236749
34Dysmetria (HP:0001310)2.89483898
35Central scotoma (HP:0000603)2.88926511
36Abnormal social behavior (HP:0012433)2.88877633
37Impaired social interactions (HP:0000735)2.88877633
38Hypoglycemic coma (HP:0001325)2.86816826
39Urinary bladder sphincter dysfunction (HP:0002839)2.80652221
40Postural instability (HP:0002172)2.79720615
41Abnormal eating behavior (HP:0100738)2.79227512
42Hemiparesis (HP:0001269)2.73993462
43Hypoglycemic seizures (HP:0002173)2.71628070
44Ankle clonus (HP:0011448)2.68955872
45Genetic anticipation (HP:0003743)2.67922119
46Dysmetric saccades (HP:0000641)2.65594741
47Impaired smooth pursuit (HP:0007772)2.64908489
48Scanning speech (HP:0002168)2.64508220
49Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.62066696
50Anterior segment dysgenesis (HP:0007700)2.57795969
51Abnormality of macular pigmentation (HP:0008002)2.56664931
52Supernumerary spleens (HP:0009799)2.55776134
53Papillary thyroid carcinoma (HP:0002895)2.55499889
54Aplasia/Hypoplasia of the fovea (HP:0008060)2.54475878
55Hypoplasia of the fovea (HP:0007750)2.54475878
56Stereotypic behavior (HP:0000733)2.53706868
57Epileptiform EEG discharges (HP:0011182)2.51900757
58Abnormality of binocular vision (HP:0011514)2.50932406
59Diplopia (HP:0000651)2.50932406
60Drooling (HP:0002307)2.50770837
61Excessive salivation (HP:0003781)2.50770837
62Status epilepticus (HP:0002133)2.50261413
63Thyroid carcinoma (HP:0002890)2.49735652
64Decreased circulating renin level (HP:0003351)2.47210881
65Hemiplegia (HP:0002301)2.46662321
66Bony spicule pigmentary retinopathy (HP:0007737)2.45963927
67Abnormal ciliary motility (HP:0012262)2.43363856
68Dyschromatopsia (HP:0007641)2.40438062
69Absent speech (HP:0001344)2.40139482
70Torticollis (HP:0000473)2.39483612
71Rhinitis (HP:0012384)2.38607262
72Gait imbalance (HP:0002141)2.36448321
73Apathy (HP:0000741)2.35563424
74Scotoma (HP:0000575)2.34654379
75Large for gestational age (HP:0001520)2.32528352
76Enlarged penis (HP:0000040)2.31724581
77Infertility (HP:0000789)2.30979180
78Bundle branch block (HP:0011710)2.30659792
79Impaired vibratory sensation (HP:0002495)2.29660001
80Neurofibrillary tangles (HP:0002185)2.28745098
81Hyperthyroidism (HP:0000836)2.27921080
82Hypothermia (HP:0002045)2.26771882
83Hyperinsulinemic hypoglycemia (HP:0000825)2.26602448
84EEG with generalized epileptiform discharges (HP:0011198)2.26548225
85Abnormality of the lower motor neuron (HP:0002366)2.23597848
86Abnormality of ocular smooth pursuit (HP:0000617)2.22798388
87Mutism (HP:0002300)2.20074141
88Congenital primary aphakia (HP:0007707)2.17194009
89Abnormal respiratory motile cilium physiology (HP:0012261)2.16944635
90Choroideremia (HP:0001139)2.16703952
91Focal dystonia (HP:0004373)2.16291139
92Megalencephaly (HP:0001355)2.16265405
93Generalized myoclonic seizures (HP:0002123)2.15932693
94Progressive inability to walk (HP:0002505)2.14379624
95Aplasia involving bones of the extremities (HP:0009825)2.13602205
96Aplasia involving bones of the upper limbs (HP:0009823)2.13602205
97Aplasia of the phalanges of the hand (HP:0009802)2.13602205
98Abnormal rod and cone electroretinograms (HP:0008323)2.13526795
99Cerebral inclusion bodies (HP:0100314)2.13441483
100Urethral obstruction (HP:0000796)2.12825176
101Abnormality of renin-angiotensin system (HP:0000847)2.11857152
102Urinary urgency (HP:0000012)2.11359115
103Diminished motivation (HP:0000745)2.10738094
104Abnormality of the fovea (HP:0000493)2.09514627
105Median cleft lip (HP:0000161)2.08886205
106Resting tremor (HP:0002322)2.08658137
107* Bradykinesia (HP:0002067)2.06823614
108Insulin-resistant diabetes mellitus (HP:0000831)2.06774190
109Annular pancreas (HP:0001734)2.06171865
110Intention tremor (HP:0002080)2.05224030
111Hyperactive renin-angiotensin system (HP:0000841)2.04751698
112Inability to walk (HP:0002540)2.03814283
113Spastic gait (HP:0002064)2.03299694
114Molar tooth sign on MRI (HP:0002419)2.03279819
115Abnormality of midbrain morphology (HP:0002418)2.03279819
116Hyperglycemia (HP:0003074)2.01929156
117Hypsarrhythmia (HP:0002521)2.01898397
118Nephrogenic diabetes insipidus (HP:0009806)2.01679655
119Abnormality of calcium-phosphate metabolism (HP:0100530)2.00983861
120Abnormality of the labia minora (HP:0012880)1.99567360
121Dynein arm defect of respiratory motile cilia (HP:0012255)1.99054592
122Absent/shortened dynein arms (HP:0200106)1.99054592
123Decreased central vision (HP:0007663)1.97854114
124Abnormal drinking behavior (HP:0030082)1.97675981
125Polydipsia (HP:0001959)1.97675981
126Protruding tongue (HP:0010808)1.96519625
127Blue irides (HP:0000635)1.96076657
128Medial flaring of the eyebrow (HP:0010747)1.95417379
129Craniofacial dystonia (HP:0012179)1.95089689
130Fair hair (HP:0002286)1.94960940
131Osteomalacia (HP:0002749)1.94157481
132Fetal akinesia sequence (HP:0001989)1.93291168
133Incomplete penetrance (HP:0003829)1.93160088
134Lower limb muscle weakness (HP:0007340)1.92376726
135Papilledema (HP:0001085)1.90770871
136Gait ataxia (HP:0002066)1.88590719
137Polyphagia (HP:0002591)1.88583226
138Hypoventilation (HP:0002791)1.88479572
139Lower limb amyotrophy (HP:0007210)1.88378173
140Abnormal EKG (HP:0003115)1.86191329
141Impulsivity (HP:0100710)1.86120038
142Hyperaldosteronism (HP:0000859)1.85387257
143Ketoacidosis (HP:0001993)1.84728625
144Specific learning disability (HP:0001328)1.83475212
145Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83074755
146Male infertility (HP:0003251)1.82614295
147Abnormality of saccadic eye movements (HP:0000570)1.82589686
148Clumsiness (HP:0002312)1.82002005
149Ventricular fibrillation (HP:0001663)1.79835733
150Prolonged QT interval (HP:0001657)1.79704249
151Thickened helices (HP:0000391)1.78187727
152Pheochromocytoma (HP:0002666)1.77075781
153Aplasia/Hypoplasia of the tibia (HP:0005772)1.77055646
154Septo-optic dysplasia (HP:0100842)1.75961578
155Facial hemangioma (HP:0000329)1.75188494
156Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74533794
157Short tibia (HP:0005736)1.71854164
158Postural tremor (HP:0002174)1.70277378
159Abnormal respiratory motile cilium morphology (HP:0005938)1.69256789
160Abnormal respiratory epithelium morphology (HP:0012253)1.69256789
161Lip pit (HP:0100267)1.68059829
162Oligodactyly (HP:0012165)1.67549687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.90473223
2NTRK34.47606663
3CASK3.14371027
4DAPK22.85540592
5MAP3K42.80817941
6MAP3K92.78373125
7MAP2K72.51939751
8FRK2.51887818
9RIPK42.19532342
10MINK12.18424358
11MAP3K122.00414984
12STK391.96064946
13PRKD31.89862613
14TNIK1.85816612
15PRPF4B1.82870884
16NTRK21.79492279
17DAPK11.76597944
18KSR21.74862481
19PAK61.72159119
20MAP2K41.65679566
21CAMKK11.62761111
22PLK21.62199590
23MARK11.61934572
24STK241.59842394
25FES1.57529951
26NTRK11.54364726
27MET1.46316416
28CDK51.44378377
29KSR11.43557982
30CDK191.34077686
31AKT31.33137010
32MAP3K131.28268248
33PTK2B1.26282614
34STK381.25440274
35SGK2231.24531168
36SGK4941.24531168
37SGK21.23800778
38PRKCG1.18303272
39SIK21.16134260
40BMPR21.15457354
41ARAF1.12922695
42OXSR11.10233618
43GRK51.09508474
44CAMK2A1.06229093
45PKN11.05917911
46FGFR21.04121935
47MAPK131.02992788
48CCNB11.02550544
49SGK30.95164202
50PNCK0.94477891
51PINK10.93779395
52CAMKK20.91408224
53TYRO30.90817698
54TAOK10.90807700
55PRKCI0.89910569
56SIK30.89598982
57MAP3K20.88302183
58MAPKAPK50.86299543
59SGK10.86092750
60TNK20.85751864
61CAMK10.85647851
62CAMK1D0.84607977
63MAPK150.84368048
64PRKCH0.83695185
65CAMK2B0.83095711
66CSNK1G20.73829503
67CDK180.73220415
68LMTK20.72060219
69RAF10.72002105
70WNK40.71191488
71PRKG10.71153452
72STK38L0.70312700
73PRKCE0.69868690
74STK110.69574492
75CDK150.68376226
76TAOK30.68374068
77NEK60.67571279
78CSNK1G10.66828331
79CDK140.66664754
80MARK20.65645977
81PTK20.65337241
82AURKA0.65006538
83WNK10.64815088
84MOS0.64353305
85PHKG20.64169300
86PHKG10.64169300
87STK30.62840843
88MAPKAPK30.62020540
89LATS20.61143515
90GRK10.60387140
91RET0.60270783
92PDPK10.59595300
93MAP3K10.58123076
94PAK30.57001128
95CAMK1G0.56576182
96CDK11A0.56484310
97MAPK100.56480720
98BRSK10.56376482
99NLK0.56183643
100FER0.55425311
101BMPR1B0.55183516
102TTK0.54501933
103CSNK1D0.54403661
104PRKAA10.54375612
105PDK10.53152199
106UHMK10.52547438
107CAMK2D0.52212410
108DAPK30.51668876
109RPS6KA30.50133646
110FGR0.49988411
111CDK90.49829572
112PRKAA20.48907830
113MAPK70.48641081
114ROCK10.46898617
115CSNK1G30.46543470
116CSNK1E0.46092399
117DYRK1A0.45887748
118TRPM70.45316032
119MAPK120.45264624
120CAMK2G0.44399245
121NME10.44241361
122PRKCZ0.42791232
123MUSK0.42754309
124WNK30.42650169
125DMPK0.42099982
126MAP3K70.42029141
127FYN0.41601295
128ADRBK10.40073358
129CAMK40.39194713
130CDC42BPA0.39148117
131MAP2K10.38522627
132BCR0.36706554
133BRAF0.35864626
134GRK70.35808896
135PRKACA0.34545702
136PRKCA0.34439284

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.70736896
2Synaptic vesicle cycle_Homo sapiens_hsa047213.26301309
3Olfactory transduction_Homo sapiens_hsa047402.84825009
4Phototransduction_Homo sapiens_hsa047442.79794057
5GABAergic synapse_Homo sapiens_hsa047272.74855638
6Circadian entrainment_Homo sapiens_hsa047132.71698634
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69987931
8* Morphine addiction_Homo sapiens_hsa050322.61511603
9Glutamatergic synapse_Homo sapiens_hsa047242.58407291
10Long-term potentiation_Homo sapiens_hsa047202.49954936
11Amphetamine addiction_Homo sapiens_hsa050312.40450666
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.39207511
13Salivary secretion_Homo sapiens_hsa049702.20266246
14Dopaminergic synapse_Homo sapiens_hsa047282.06920593
15Insulin secretion_Homo sapiens_hsa049111.98872561
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88745950
17Cholinergic synapse_Homo sapiens_hsa047251.87041918
18Renin secretion_Homo sapiens_hsa049241.84290291
19Gastric acid secretion_Homo sapiens_hsa049711.82894393
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73346908
21Collecting duct acid secretion_Homo sapiens_hsa049661.70002289
22Taste transduction_Homo sapiens_hsa047421.69418972
23Cocaine addiction_Homo sapiens_hsa050301.69038502
24Serotonergic synapse_Homo sapiens_hsa047261.67791430
25Calcium signaling pathway_Homo sapiens_hsa040201.66464336
26Oxytocin signaling pathway_Homo sapiens_hsa049211.66138487
27Long-term depression_Homo sapiens_hsa047301.57198376
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48669086
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35284244
30cAMP signaling pathway_Homo sapiens_hsa040241.32802308
31GnRH signaling pathway_Homo sapiens_hsa049121.32596996
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24384430
33Gap junction_Homo sapiens_hsa045401.22110495
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20546793
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20490943
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16797948
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13123957
38Butanoate metabolism_Homo sapiens_hsa006501.12517984
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11984151
40Folate biosynthesis_Homo sapiens_hsa007901.10930480
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10579538
42ABC transporters_Homo sapiens_hsa020101.09762747
43Vibrio cholerae infection_Homo sapiens_hsa051101.08704328
44Basal transcription factors_Homo sapiens_hsa030221.04898114
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.02052607
46Glioma_Homo sapiens_hsa052141.00578709
47Vitamin B6 metabolism_Homo sapiens_hsa007500.97005045
48Nitrogen metabolism_Homo sapiens_hsa009100.96640328
49Axon guidance_Homo sapiens_hsa043600.95863875
50Estrogen signaling pathway_Homo sapiens_hsa049150.95376989
51Melanogenesis_Homo sapiens_hsa049160.94654799
52Type II diabetes mellitus_Homo sapiens_hsa049300.92812811
53ErbB signaling pathway_Homo sapiens_hsa040120.90733671
54Pancreatic secretion_Homo sapiens_hsa049720.87921218
55Cardiac muscle contraction_Homo sapiens_hsa042600.87773607
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86935330
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84888451
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.82720642
59Dorso-ventral axis formation_Homo sapiens_hsa043200.80390501
60Dilated cardiomyopathy_Homo sapiens_hsa054140.79150754
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78481402
62Circadian rhythm_Homo sapiens_hsa047100.76636076
63Fatty acid biosynthesis_Homo sapiens_hsa000610.71620093
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71591404
65Thyroid hormone synthesis_Homo sapiens_hsa049180.69742528
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67901165
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67775221
68beta-Alanine metabolism_Homo sapiens_hsa004100.67354073
69MAPK signaling pathway_Homo sapiens_hsa040100.66838538
70Caffeine metabolism_Homo sapiens_hsa002320.66804409
71Choline metabolism in cancer_Homo sapiens_hsa052310.65719231
72Regulation of autophagy_Homo sapiens_hsa041400.63940061
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63784008
74Histidine metabolism_Homo sapiens_hsa003400.63395365
75Rap1 signaling pathway_Homo sapiens_hsa040150.60517198
76Ras signaling pathway_Homo sapiens_hsa040140.60134071
77Oocyte meiosis_Homo sapiens_hsa041140.58921472
78Glucagon signaling pathway_Homo sapiens_hsa049220.54406537
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54355505
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54079748
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53523384
82Inositol phosphate metabolism_Homo sapiens_hsa005620.53439189
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49428734
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49363465
85Bile secretion_Homo sapiens_hsa049760.47606188
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47374523
87Type I diabetes mellitus_Homo sapiens_hsa049400.46993858
88African trypanosomiasis_Homo sapiens_hsa051430.46855280
89Propanoate metabolism_Homo sapiens_hsa006400.44102489
90VEGF signaling pathway_Homo sapiens_hsa043700.43884219
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.43826232
92Fatty acid elongation_Homo sapiens_hsa000620.42938224
93Ovarian steroidogenesis_Homo sapiens_hsa049130.42748186
94Protein digestion and absorption_Homo sapiens_hsa049740.42720963
95Alcoholism_Homo sapiens_hsa050340.40937631
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40915742
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.40758514
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40395362
99Rheumatoid arthritis_Homo sapiens_hsa053230.40079918
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39935495
101Hippo signaling pathway_Homo sapiens_hsa043900.38853638
102Tight junction_Homo sapiens_hsa045300.38714373
103ECM-receptor interaction_Homo sapiens_hsa045120.38276390
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37335144
105Arginine biosynthesis_Homo sapiens_hsa002200.36679159
106PPAR signaling pathway_Homo sapiens_hsa033200.36546073
107Endocytosis_Homo sapiens_hsa041440.36417233
108AMPK signaling pathway_Homo sapiens_hsa041520.35450998
109Chemokine signaling pathway_Homo sapiens_hsa040620.35165220
110Wnt signaling pathway_Homo sapiens_hsa043100.33719939
111Alzheimers disease_Homo sapiens_hsa050100.33590333
112Renal cell carcinoma_Homo sapiens_hsa052110.32810306
113Mineral absorption_Homo sapiens_hsa049780.32085605
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31790710
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30887430
116Non-small cell lung cancer_Homo sapiens_hsa052230.30881829
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30803567
118Ether lipid metabolism_Homo sapiens_hsa005650.30443847
119TGF-beta signaling pathway_Homo sapiens_hsa043500.29911778
120Prion diseases_Homo sapiens_hsa050200.29833172
121mTOR signaling pathway_Homo sapiens_hsa041500.29088853
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28732402
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28389856
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27403439
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.26361398

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