PDE9A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug catabolic process (GO:0042737)4.23571121
2nucleobase catabolic process (GO:0046113)4.05371079
3flavonoid metabolic process (GO:0009812)4.00497770
4exogenous drug catabolic process (GO:0042738)3.89519882
5sulfur amino acid catabolic process (GO:0000098)3.88361916
6pyrimidine nucleobase catabolic process (GO:0006208)3.88277960
7L-phenylalanine catabolic process (GO:0006559)3.79708020
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.79708020
9tryptophan catabolic process (GO:0006569)3.73785614
10indole-containing compound catabolic process (GO:0042436)3.73785614
11indolalkylamine catabolic process (GO:0046218)3.73785614
12aromatic amino acid family catabolic process (GO:0009074)3.72403153
13somite development (GO:0061053)3.71293590
14bile acid and bile salt transport (GO:0015721)3.68467585
15L-phenylalanine metabolic process (GO:0006558)3.68446090
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.68446090
17kynurenine metabolic process (GO:0070189)3.63915038
18presynaptic membrane assembly (GO:0097105)3.62961941
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.61764377
20vocalization behavior (GO:0071625)3.60979605
21inner ear receptor cell development (GO:0060119)3.59523914
22intestinal absorption (GO:0050892)3.54245287
23glyoxylate metabolic process (GO:0046487)3.53876162
24calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.51643465
25nephron tubule formation (GO:0072079)3.48491427
26cellular ketone body metabolic process (GO:0046950)3.47171804
27presynaptic membrane organization (GO:0097090)3.46786320
28regulation of cholesterol homeostasis (GO:2000188)3.39200718
29regulation of bile acid biosynthetic process (GO:0070857)3.37467566
30tryptophan metabolic process (GO:0006568)3.34667246
31otic vesicle formation (GO:0030916)3.33936156
32glutamate metabolic process (GO:0006536)3.29607587
33L-serine metabolic process (GO:0006563)3.27052554
34cysteine metabolic process (GO:0006534)3.23923420
35arginine metabolic process (GO:0006525)3.16400821
36artery development (GO:0060840)3.15033325
37intestinal cholesterol absorption (GO:0030299)3.14835337
38urea metabolic process (GO:0019627)3.14606162
39urea cycle (GO:0000050)3.14606162
40bundle of His cell to Purkinje myocyte communication (GO:0086069)3.12890440
41homocysteine metabolic process (GO:0050667)3.12837976
42chromatin remodeling at centromere (GO:0031055)3.10104643
43arginine catabolic process (GO:0006527)3.08579767
44behavioral response to nicotine (GO:0035095)3.06535312
45bile acid biosynthetic process (GO:0006699)3.04608921
46alpha-linolenic acid metabolic process (GO:0036109)3.04526426
47neurotransmitter biosynthetic process (GO:0042136)3.04197801
48high-density lipoprotein particle remodeling (GO:0034375)3.01876808
49drug transmembrane transport (GO:0006855)3.00930816
50regulation of cholesterol esterification (GO:0010872)3.00185043
51negative regulation of cholesterol transport (GO:0032375)2.99545221
52negative regulation of sterol transport (GO:0032372)2.99545221
53calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.99009769
54bile acid metabolic process (GO:0008206)2.96316997
55short-chain fatty acid metabolic process (GO:0046459)2.95875611
56positive regulation of gastrulation (GO:2000543)2.95814195
57mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.95124390
58limb bud formation (GO:0060174)2.94758497
59substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.94029315
60substrate-independent telencephalic tangential migration (GO:0021826)2.94029315
61ketone body metabolic process (GO:1902224)2.92878628
62lung-associated mesenchyme development (GO:0060484)2.92769991
63L-fucose catabolic process (GO:0042355)2.89524428
64fucose catabolic process (GO:0019317)2.89524428
65L-fucose metabolic process (GO:0042354)2.89524428
66lysine metabolic process (GO:0006553)2.89295292
67lysine catabolic process (GO:0006554)2.89295292
68nephron epithelium morphogenesis (GO:0072088)2.88852556
69nephron tubule morphogenesis (GO:0072078)2.88852556
70cellular modified amino acid catabolic process (GO:0042219)2.88781914
71cell proliferation in forebrain (GO:0021846)2.86479094
72CENP-A containing nucleosome assembly (GO:0034080)2.86071418
73short-term memory (GO:0007614)2.85872404
74reverse cholesterol transport (GO:0043691)2.85370863
75iron coordination entity transport (GO:1901678)2.84372576
76maintenance of gastrointestinal epithelium (GO:0030277)2.82467455
77nitrogen cycle metabolic process (GO:0071941)2.81686467
78coenzyme catabolic process (GO:0009109)2.81586831
79kidney morphogenesis (GO:0060993)2.79550911
80cellular amino acid catabolic process (GO:0009063)2.79151026
81alpha-amino acid catabolic process (GO:1901606)2.78151667
82serine family amino acid biosynthetic process (GO:0009070)2.77366854
83UDP-N-acetylglucosamine metabolic process (GO:0006047)2.77318267
84macromolecular complex remodeling (GO:0034367)2.75574552
85plasma lipoprotein particle remodeling (GO:0034369)2.75574552
86protein-lipid complex remodeling (GO:0034368)2.75574552
87phospholipid efflux (GO:0033700)2.74886102
88cellular glucuronidation (GO:0052695)2.73445852
89negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.72809923
90prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.72010667
91dicarboxylic acid biosynthetic process (GO:0043650)2.71005578
92gamma-aminobutyric acid transport (GO:0015812)2.70603880
93postsynaptic membrane organization (GO:0001941)2.68501355
94serine family amino acid catabolic process (GO:0009071)2.67184781
95cochlea development (GO:0090102)2.66743700
96urate metabolic process (GO:0046415)2.66698476
97vitamin transmembrane transport (GO:0035461)2.65803883
98drug transport (GO:0015893)2.64308130
99glutamine family amino acid catabolic process (GO:0009065)2.61441401
100uronic acid metabolic process (GO:0006063)2.61081141
101glucuronate metabolic process (GO:0019585)2.61081141
102dicarboxylic acid catabolic process (GO:0043649)2.60807911
103ethanol oxidation (GO:0006069)2.60615090
104neurotransmitter-gated ion channel clustering (GO:0072578)2.60418477
105hemidesmosome assembly (GO:0031581)2.59152591
106triglyceride homeostasis (GO:0070328)2.58899164
107acylglycerol homeostasis (GO:0055090)2.58899164
108metanephric nephron tubule development (GO:0072234)2.58428272
109metanephric tubule development (GO:0072170)2.58428272
110cell communication involved in cardiac conduction (GO:0086065)2.57213552
111regulation of triglyceride catabolic process (GO:0010896)2.56796475
112axonal fasciculation (GO:0007413)2.56579934
113actin filament depolymerization (GO:0030042)2.55962319
114dorsal/ventral axis specification (GO:0009950)2.55801811
115negative regulation of sodium ion transport (GO:0010766)2.55354195
116neuron fate determination (GO:0048664)2.55330548
117aromatic amino acid family metabolic process (GO:0009072)2.54550330
118amino-acid betaine metabolic process (GO:0006577)2.54514457
119neurotransmitter metabolic process (GO:0042133)2.54156805
120indolalkylamine metabolic process (GO:0006586)2.53628015
121transcytosis (GO:0045056)2.53602393
122negative regulation of protein activation cascade (GO:2000258)2.52258434
123midgut development (GO:0007494)2.51203889
124histone exchange (GO:0043486)2.50690171
125neurotransmitter secretion (GO:0007269)2.50109542
126regulation of cell fate specification (GO:0042659)2.49830665
127apical protein localization (GO:0045176)2.49137265
128regulation of protein activation cascade (GO:2000257)2.49134408
129response to pheromone (GO:0019236)2.49051478
130epithelial structure maintenance (GO:0010669)2.48967393
131establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.48740623
132phospholipid homeostasis (GO:0055091)2.47587554
133urogenital system development (GO:0001655)2.46512161
134plasma lipoprotein particle assembly (GO:0034377)2.46267945
135fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.46040921
136vitamin A metabolic process (GO:0006776)2.45264464
137locomotory exploration behavior (GO:0035641)2.45014640
138thyroid hormone metabolic process (GO:0042403)2.44255280
139negative regulation of fibrinolysis (GO:0051918)2.43964479
140regulation of mesenchymal cell apoptotic process (GO:2001053)2.43715921
141regulation of posttranscriptional gene silencing (GO:0060147)2.43349616
142regulation of gene silencing by miRNA (GO:0060964)2.43349616
143regulation of gene silencing by RNA (GO:0060966)2.43349616
144specification of organ identity (GO:0010092)2.42283612
145C4-dicarboxylate transport (GO:0015740)2.41461182
146RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.40448889
147tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.40448889
148regulation of stem cell maintenance (GO:2000036)2.39866703
149cell migration involved in gastrulation (GO:0042074)2.39589969
150hindbrain development (GO:0030902)2.38378866
151DNA replication-independent nucleosome organization (GO:0034724)2.35787609
152DNA replication-independent nucleosome assembly (GO:0006336)2.35787609
153lens fiber cell development (GO:0070307)2.34858761
154collecting duct development (GO:0072044)2.33310560
155cerebral cortex radially oriented cell migration (GO:0021799)2.33217983
156positive regulation of neurological system process (GO:0031646)2.33105302
157kinetochore assembly (GO:0051382)2.32489753
158embryonic pattern specification (GO:0009880)2.32208567
159cranial nerve development (GO:0021545)2.32074677
160regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.30450497
161neuron recognition (GO:0008038)2.30349496
162neuronal stem cell maintenance (GO:0097150)2.28297213
163cell-cell signaling involved in cell fate commitment (GO:0045168)2.27873258
164paraxial mesoderm development (GO:0048339)2.27571329
165regulation of gastrulation (GO:0010470)2.27001919
166regulation of guanylate cyclase activity (GO:0031282)2.26655135
167negative regulation of transcription regulatory region DNA binding (GO:2000678)2.26113483
168water-soluble vitamin biosynthetic process (GO:0042364)2.25983818
169neuron cell-cell adhesion (GO:0007158)2.25721721
170spinal cord development (GO:0021510)2.25253064
171renal system development (GO:0072001)2.25193292
172branching involved in prostate gland morphogenesis (GO:0060442)2.24400864
173auditory receptor cell differentiation (GO:0042491)2.22900238
174digestive tract morphogenesis (GO:0048546)2.22274094
175negative regulation of cell fate commitment (GO:0010454)2.22214960
176nephron tubule development (GO:0072080)2.21212804
177G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.21196617
178regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.21100767
179negative regulation of translation, ncRNA-mediated (GO:0040033)2.20659269
180regulation of translation, ncRNA-mediated (GO:0045974)2.20659269
181negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.20659269
182regulation of cell fate commitment (GO:0010453)2.20330400
183pattern specification involved in kidney development (GO:0061004)2.19247794
184anterior/posterior axis specification, embryo (GO:0008595)2.19025571
185regulation of mesoderm development (GO:2000380)2.17671820
186metanephric nephron epithelium development (GO:0072243)2.17094782
187mesenchymal to epithelial transition (GO:0060231)2.15910433
188developmental induction (GO:0031128)2.14986363
189DNA strand renaturation (GO:0000733)2.14479061
190epithelial cell maturation (GO:0002070)2.13945360
191regulation of systemic arterial blood pressure by hormone (GO:0001990)2.13542801
192regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.13542801
193endocrine process (GO:0050886)2.13542801
194dorsal/ventral pattern formation (GO:0009953)2.11848875
195regulation of systemic arterial blood pressure (GO:0003073)2.11676265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.86242249
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.84784595
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05633113
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.68741026
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59283980
6EZH2_22144423_ChIP-Seq_EOC_Human2.58798856
7* CDX2_20551321_ChIP-Seq_CACO-2_Human2.40321540
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.36102109
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.36102109
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.36102109
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32045395
12VDR_22108803_ChIP-Seq_LS180_Human2.26844478
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.26113557
14* LXR_22158963_ChIP-Seq_LIVER_Mouse2.20149200
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10639583
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06452984
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06452984
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04069050
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.02488964
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01850275
21GBX2_23144817_ChIP-Seq_PC3_Human2.01058096
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95785069
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94159799
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.91227174
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.88016102
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84404710
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84304254
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.78724090
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75502712
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.74567578
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.72399038
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72262884
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70126730
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.67852544
35* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.66820333
36* DROSHA_22980978_ChIP-Seq_HELA_Human1.65149740
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.64876726
38IGF1R_20145208_ChIP-Seq_DFB_Human1.63971490
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60013688
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57399955
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54059527
42AR_21909140_ChIP-Seq_LNCAP_Human1.53359729
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52237848
44RNF2_27304074_Chip-Seq_NSC_Mouse1.49529642
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49277589
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48411179
47SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.47016210
48BCAT_22108803_ChIP-Seq_LS180_Human1.44226279
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43939524
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.42794515
51* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40774027
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.39838380
53REST_21632747_ChIP-Seq_MESCs_Mouse1.39499693
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39080887
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38328038
56* PIAS1_25552417_ChIP-Seq_VCAP_Human1.36365268
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.36140278
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33775139
59POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.33356640
60TAF15_26573619_Chip-Seq_HEK293_Human1.30824707
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.30766613
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28904016
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28632400
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28131592
65STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27584172
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26771572
67SOX2_20726797_ChIP-Seq_SW620_Human1.26750940
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26352778
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25976243
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24402126
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.24300633
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.22479855
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21002230
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19249268
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.19077080
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18982117
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.18423674
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.18238385
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17260091
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.16265833
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.15553175
82ISL1_27105846_Chip-Seq_CPCs_Mouse1.14382726
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14244305
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13601941
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13577634
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13020629
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12282016
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11956202
89AHR_22903824_ChIP-Seq_MCF-7_Human1.11735855
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11646371
91* ARNT_22903824_ChIP-Seq_MCF-7_Human1.10104659
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.09829195
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09059590
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07913077
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06936721
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.05588439
97SMAD3_21741376_ChIP-Seq_HESCs_Human1.05359571
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04018963
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03671267
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03671267
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.03541741
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03462767
103* SMAD4_21741376_ChIP-Seq_HESCs_Human1.03417026
104* AR_25329375_ChIP-Seq_VCAP_Human1.02983035
105OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02533064
106* FOXA2_19822575_ChIP-Seq_HepG2_Human1.02361224
107EWS_26573619_Chip-Seq_HEK293_Human1.02258967
108TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02011532
109SMAD4_21799915_ChIP-Seq_A2780_Human1.01808332
110RARB_27405468_Chip-Seq_BRAIN_Mouse1.00371576
111TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98284801
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98159031
113TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97714773
114FUS_26573619_Chip-Seq_HEK293_Human0.97296382
115RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96983543
116P300_19829295_ChIP-Seq_ESCs_Human0.96395337
117TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94943140
118* SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93792331
119AR_21572438_ChIP-Seq_LNCaP_Human0.93785838
120NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93637151
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93346694
122HTT_18923047_ChIP-ChIP_STHdh_Human0.93249665
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92814393
124ZNF274_21170338_ChIP-Seq_K562_Hela0.92740730
125* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92577324
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92095886
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.91462068
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90688066
129GATA4_25053715_ChIP-Seq_YYC3_Human0.89929969
130TP53_18474530_ChIP-ChIP_U2OS_Human0.89724592
131SMAD_19615063_ChIP-ChIP_OVARY_Human0.89493225
132TP53_20018659_ChIP-ChIP_R1E_Mouse0.89349132
133WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88941353
134* SMAD3_21741376_ChIP-Seq_EPCs_Human0.88825093
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88311673
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88311673
137TCF4_22108803_ChIP-Seq_LS180_Human0.88162292
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87820617
139* RUNX2_22187159_ChIP-Seq_PCA_Human0.87063569
140ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.86836902
141* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86200817
142* AR_19668381_ChIP-Seq_PC3_Human0.86137939
143NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86051276
144* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85908190
145NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85217303
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84745559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.76571580
2MP0002139_abnormal_hepatobiliary_system4.97388348
3MP0006292_abnormal_olfactory_placode4.26178201
4MP0005085_abnormal_gallbladder_physiolo4.08089635
5MP0005365_abnormal_bile_salt3.50675039
6MP0008875_abnormal_xenobiotic_pharmacok3.49866825
7MP0002822_catalepsy3.38083907
8MP0010234_abnormal_vibrissa_follicle3.15591781
9MP0001666_abnormal_nutrient_absorption2.93868694
10MP0003136_yellow_coat_color2.54691500
11MP0003252_abnormal_bile_duct2.49961271
12MP0004133_heterotaxia2.21002017
13MP0004859_abnormal_synaptic_plasticity2.20406685
14MP0010329_abnormal_lipoprotein_level2.18316708
15MP0003122_maternal_imprinting2.10280942
16MP0002876_abnormal_thyroid_physiology2.02356274
17MP0000049_abnormal_middle_ear2.01441491
18MP0000462_abnormal_digestive_system2.01207695
19MP0003890_abnormal_embryonic-extraembry1.94954946
20MP0003806_abnormal_nucleotide_metabolis1.93893361
21MP0000631_abnormal_neuroendocrine_gland1.87363782
22MP0005332_abnormal_amino_acid1.86957705
23MP0004019_abnormal_vitamin_homeostasis1.84519679
24MP0010030_abnormal_orbit_morphology1.81407997
25MP0003635_abnormal_synaptic_transmissio1.74410486
26MP0004858_abnormal_nervous_system1.71902480
27MP0000538_abnormal_urinary_bladder1.67528767
28MP0004264_abnormal_extraembryonic_tissu1.67079799
29MP0005646_abnormal_pituitary_gland1.63107856
30MP0001440_abnormal_grooming_behavior1.62828866
31MP0001293_anophthalmia1.59212820
32MP0002249_abnormal_larynx_morphology1.58533949
33MP0003868_abnormal_feces_composition1.57570387
34MP0002102_abnormal_ear_morphology1.55626009
35MP0002938_white_spotting1.55587309
36MP0003787_abnormal_imprinting1.53470374
37MP0009745_abnormal_behavioral_response1.52430982
38MP0008877_abnormal_DNA_methylation1.43977812
39MP0001188_hyperpigmentation1.43852433
40MP0001501_abnormal_sleep_pattern1.43654723
41MP0000537_abnormal_urethra_morphology1.43468427
42MP0003937_abnormal_limbs/digits/tail_de1.43438379
43MP0003315_abnormal_perineum_morphology1.42851378
44MP0003121_genomic_imprinting1.41412102
45MP0001664_abnormal_digestion1.40679727
46MP0002234_abnormal_pharynx_morphology1.40445855
47MP0004270_analgesia1.40291153
48MP0002063_abnormal_learning/memory/cond1.38851453
49MP0005167_abnormal_blood-brain_barrier1.38171171
50MP0004043_abnormal_pH_regulation1.37332191
51MP0005645_abnormal_hypothalamus_physiol1.36655917
52MP0002736_abnormal_nociception_after1.35326982
53MP0003880_abnormal_central_pattern1.35192605
54MP0000778_abnormal_nervous_system1.34747074
55MP0002734_abnormal_mechanical_nocicepti1.32922704
56MP0001286_abnormal_eye_development1.32690772
57MP0003119_abnormal_digestive_system1.32268173
58MP0000026_abnormal_inner_ear1.31257491
59MP0002697_abnormal_eye_size1.31169789
60MP0001849_ear_inflammation1.30059864
61MP0001968_abnormal_touch/_nociception1.29002169
62MP0002572_abnormal_emotion/affect_behav1.28246089
63MP0003329_amyloid_beta_deposits1.28238846
64MP0002064_seizures1.28180691
65MP0004885_abnormal_endolymph1.27886321
66MP0002138_abnormal_hepatobiliary_system1.26584547
67MP0005187_abnormal_penis_morphology1.24125204
68MP0009046_muscle_twitch1.21176237
69MP0000534_abnormal_ureter_morphology1.17976138
70MP0003718_maternal_effect1.17422662
71MP0008872_abnormal_physiological_respon1.15760531
72MP0003878_abnormal_ear_physiology1.14984028
73MP0005377_hearing/vestibular/ear_phenot1.14984028
74MP0002735_abnormal_chemical_nociception1.14345524
75MP0002233_abnormal_nose_morphology1.14256019
76MP0003861_abnormal_nervous_system1.13506464
77MP0001486_abnormal_startle_reflex1.13445796
78MP0005381_digestive/alimentary_phenotyp1.10411065
79MP0003755_abnormal_palate_morphology1.10173883
80MP0002272_abnormal_nervous_system1.10041039
81MP0002111_abnormal_tail_morphology1.09973437
82MP0002557_abnormal_social/conspecific_i1.09811869
83MP0000955_abnormal_spinal_cord1.08608319
84MP0002638_abnormal_pupillary_reflex1.08427022
85MP0004147_increased_porphyrin_level1.08087917
86MP0002733_abnormal_thermal_nociception1.04872878
87MP0003866_abnormal_defecation1.03877951
88MP0005423_abnormal_somatic_nervous1.03689621
89MP0002118_abnormal_lipid_homeostasis1.03199414
90MP0005248_abnormal_Harderian_gland1.02820584
91MP0003011_delayed_dark_adaptation1.02529339
92MP0005083_abnormal_biliary_tract1.01134991
93MP0003942_abnormal_urinary_system0.99560853
94MP0002277_abnormal_respiratory_mucosa0.99027380
95MP0009780_abnormal_chondrocyte_physiolo0.98780798
96MP0004742_abnormal_vestibular_system0.97339567
97MP0001663_abnormal_digestive_system0.95999221
98MP0001765_abnormal_ion_homeostasis0.93606248
99MP0002067_abnormal_sensory_capabilities0.93450645
100MP0002116_abnormal_craniofacial_bone0.92573705
101MP0002152_abnormal_brain_morphology0.92531326
102MP0001529_abnormal_vocalization0.91564839
103MP0000678_abnormal_parathyroid_gland0.91335899
104MP0004924_abnormal_behavior0.91069628
105MP0005386_behavior/neurological_phenoty0.91069628
106MP0003283_abnormal_digestive_organ0.90742562
107MP0002752_abnormal_somatic_nervous0.90660018
108MP0002254_reproductive_system_inflammat0.90572518
109MP0003123_paternal_imprinting0.89891333
110MP0008789_abnormal_olfactory_epithelium0.89521523
111MP0003693_abnormal_embryo_hatching0.88410614
112MP0005636_abnormal_mineral_homeostasis0.86989892
113MP0002653_abnormal_ependyma_morphology0.86471402
114MP0009384_cardiac_valve_regurgitation0.85663635
115MP0000566_synostosis0.85523235
116MP0001984_abnormal_olfaction0.85032953
117MP0005394_taste/olfaction_phenotype0.84762456
118MP0005499_abnormal_olfactory_system0.84762456
119MP0001502_abnormal_circadian_rhythm0.83425419
120MP0001485_abnormal_pinna_reflex0.83326998
121MP0009053_abnormal_anal_canal0.83077008
122MP0000762_abnormal_tongue_morphology0.82566385
123MP0009379_abnormal_foot_pigmentation0.82422399
124MP0005367_renal/urinary_system_phenotyp0.82395940
125MP0000516_abnormal_urinary_system0.82395940
126MP0002184_abnormal_innervation0.81166628
127MP0003879_abnormal_hair_cell0.80821829
128MP0003191_abnormal_cellular_cholesterol0.80772120
129MP0009643_abnormal_urine_homeostasis0.80438082
130MP0002796_impaired_skin_barrier0.79598031
131MP0005584_abnormal_enzyme/coenzyme_acti0.79357914
132MP0001177_atelectasis0.78411123
133MP0006276_abnormal_autonomic_nervous0.77318063
134MP0001970_abnormal_pain_threshold0.76477273
135MP0009840_abnormal_foam_cell0.75137403
136MP0009697_abnormal_copulation0.75104450
137MP0008569_lethality_at_weaning0.74989844
138MP0003385_abnormal_body_wall0.74333859
139MP0000604_amyloidosis0.74211451
140MP0003183_abnormal_peptide_metabolism0.73034493
141MP0002069_abnormal_eating/drinking_beha0.72614332
142MP0002909_abnormal_adrenal_gland0.71568474
143MP0004215_abnormal_myocardial_fiber0.70917787
144MP0005319_abnormal_enzyme/_coenzyme0.70673046
145MP0003705_abnormal_hypodermis_morpholog0.70546831
146MP0003938_abnormal_ear_development0.68918801
147MP0000467_abnormal_esophagus_morphology0.67741265
148MP0000609_abnormal_liver_physiology0.65576204
149MP0001764_abnormal_homeostasis0.65424132
150MP0005551_abnormal_eye_electrophysiolog0.65135369
151MP0001963_abnormal_hearing_physiology0.63242871
152MP0005647_abnormal_sex_gland0.61994558

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)4.96374056
2Abnormality of glutamine family amino acid metabolism (HP:0010902)4.11223565
3Onycholysis (HP:0001806)4.07689062
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.00701671
5Deep venous thrombosis (HP:0002625)3.97974824
6Hypobetalipoproteinemia (HP:0003563)3.93924266
7Conjugated hyperbilirubinemia (HP:0002908)3.78784967
8Right ventricular cardiomyopathy (HP:0011663)3.47356492
9Hyperglycinuria (HP:0003108)3.38376069
10Septo-optic dysplasia (HP:0100842)3.37390286
11Hyperactive renin-angiotensin system (HP:0000841)3.36172150
12Fragile nails (HP:0001808)3.28512098
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.23811983
14Abnormality of the labia minora (HP:0012880)3.23388209
15Xanthomatosis (HP:0000991)3.11696491
16Fat malabsorption (HP:0002630)3.08221870
17Ileus (HP:0002595)3.03543555
18Abnormality of serine family amino acid metabolism (HP:0010894)3.00355247
19Abnormality of glycine metabolism (HP:0010895)3.00355247
20Sensorimotor neuropathy (HP:0007141)2.94072376
21Myokymia (HP:0002411)2.90859784
22Metabolic alkalosis (HP:0200114)2.88755661
23Hypomagnesemia (HP:0002917)2.88097295
24Malnutrition (HP:0004395)2.81371507
25Ketoacidosis (HP:0001993)2.80407734
26Partial duplication of thumb phalanx (HP:0009944)2.78703832
27Goiter (HP:0000853)2.76856926
28Gout (HP:0001997)2.76756120
29Ketosis (HP:0001946)2.76583969
30Hyperventilation (HP:0002883)2.72493929
31Hyperammonemia (HP:0001987)2.71952568
32Hypolipoproteinemia (HP:0010981)2.68219936
33Focal motor seizures (HP:0011153)2.67020017
34Milia (HP:0001056)2.63611847
35Impulsivity (HP:0100710)2.63508319
36Abnormality of magnesium homeostasis (HP:0004921)2.63430820
37Hyperglycinemia (HP:0002154)2.63208402
38Anophthalmia (HP:0000528)2.61922073
39Abnormal number of incisors (HP:0011064)2.54279887
40Vascular calcification (HP:0004934)2.53214899
41Abnormality of sulfur amino acid metabolism (HP:0004339)2.49148045
42Enlarged kidneys (HP:0000105)2.46007763
43Alkalosis (HP:0001948)2.41743731
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.40257692
45Hydroxyprolinuria (HP:0003080)2.39250522
46Abnormality of proline metabolism (HP:0010907)2.39250522
47Thyroid-stimulating hormone excess (HP:0002925)2.38915679
48Delayed CNS myelination (HP:0002188)2.36787538
49Facial shape deformation (HP:0011334)2.35561045
50Potter facies (HP:0002009)2.35561045
51Atrophic scars (HP:0001075)2.35195845
52Gastrointestinal atresia (HP:0002589)2.34098303
53Prolonged partial thromboplastin time (HP:0003645)2.30516631
54Widely patent fontanelles and sutures (HP:0004492)2.29194268
55Ureteral stenosis (HP:0000071)2.28050512
56Tetany (HP:0001281)2.27893997
57Abnormality of purine metabolism (HP:0004352)2.27485173
58Morphological abnormality of the middle ear (HP:0008609)2.27177863
59Partial duplication of the phalanx of hand (HP:0009999)2.26023390
60Epidermoid cyst (HP:0200040)2.25860556
61Optic nerve hypoplasia (HP:0000609)2.23868585
62Abnormal tarsal ossification (HP:0008369)2.23072683
63Hyperlipoproteinemia (HP:0010980)2.21948560
64Complement deficiency (HP:0004431)2.21808915
65Focal segmental glomerulosclerosis (HP:0000097)2.20734798
66Reticulocytopenia (HP:0001896)2.19803675
67Abnormal drinking behavior (HP:0030082)2.19265941
68Polydipsia (HP:0001959)2.19265941
69Cardiovascular calcification (HP:0011915)2.17651716
70Dehydration (HP:0001944)2.17502696
71Bronchomalacia (HP:0002780)2.13961499
72Rib fusion (HP:0000902)2.12236735
73Oligodactyly (hands) (HP:0001180)2.11872958
74Confusion (HP:0001289)2.10728054
75Bicornuate uterus (HP:0000813)2.09809481
76Abnormality of the nasal septum (HP:0000419)2.09670199
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.08591380
78Decreased circulating renin level (HP:0003351)2.08408115
79Intestinal atresia (HP:0011100)2.06464818
80Metabolic acidosis (HP:0001942)2.06122233
81Spontaneous abortion (HP:0005268)2.04536380
82Absent septum pellucidum (HP:0001331)2.04267806
83Spastic diplegia (HP:0001264)2.04094837
84True hermaphroditism (HP:0010459)2.03708620
85Pendular nystagmus (HP:0012043)2.03036823
86Glomerulosclerosis (HP:0000096)2.01861720
87Median cleft lip (HP:0000161)2.01813647
88Abnormality of the gallbladder (HP:0005264)2.01751411
89Choanal stenosis (HP:0000452)2.00716847
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00573805
91Action tremor (HP:0002345)1.98727621
92Status epilepticus (HP:0002133)1.98620411
93Cutaneous finger syndactyly (HP:0010554)1.97997919
94Aplasia/Hypoplasia of the sternum (HP:0006714)1.97519770
95Maternal diabetes (HP:0009800)1.97417519
96Hypoalphalipoproteinemia (HP:0003233)1.97391562
97Synostosis involving the elbow (HP:0003938)1.97294336
98Humeroradial synostosis (HP:0003041)1.97294336
99Bilateral microphthalmos (HP:0007633)1.96344411
100Ureteral obstruction (HP:0006000)1.96159067
101Esophageal atresia (HP:0002032)1.96083702
102Lethargy (HP:0001254)1.95896164
103Abnormality of nucleobase metabolism (HP:0010932)1.95681651
104Focal seizures (HP:0007359)1.95563853
105Renal hypoplasia (HP:0000089)1.95311918
106Polyphagia (HP:0002591)1.94835088
107Genital tract atresia (HP:0001827)1.93619843
108Progressive cerebellar ataxia (HP:0002073)1.93401998
109Bifid scrotum (HP:0000048)1.93137942
110Abnormality of renin-angiotensin system (HP:0000847)1.92330048
111Late onset (HP:0003584)1.92069191
112Pancreatic cysts (HP:0001737)1.91416929
113Abnormality of the aortic arch (HP:0012303)1.90191663
114Atonic seizures (HP:0010819)1.90067090
115Vaginal atresia (HP:0000148)1.89694190
116Increased purine levels (HP:0004368)1.89307991
117Hyperuricemia (HP:0002149)1.89307991
118Shawl scrotum (HP:0000049)1.89027506
119Chronic bronchitis (HP:0004469)1.88774902
120Steatorrhea (HP:0002570)1.88434109
121Febrile seizures (HP:0002373)1.88288931
122Epileptic encephalopathy (HP:0200134)1.87585926
123Abnormality of the vitamin B12 metabolism (HP:0004341)1.87297777
124Midline defect of the nose (HP:0004122)1.87012729
125Patellar aplasia (HP:0006443)1.86572858
126Septate vagina (HP:0001153)1.85815854
127Hyperbilirubinemia (HP:0002904)1.85699394
128Abnormality of chloride homeostasis (HP:0011422)1.84718818
129Bifid tongue (HP:0010297)1.84141986
130Poor suck (HP:0002033)1.84118708
131Abnormal gallbladder physiology (HP:0012438)1.83967687
132Cholecystitis (HP:0001082)1.83967687
133Abnormality of vitamin B metabolism (HP:0004340)1.83506936
134Hyperaldosteronism (HP:0000859)1.82871382
135Abnormal eating behavior (HP:0100738)1.82252769
136Absent eyebrow (HP:0002223)1.82245670
137Pancreatic fibrosis (HP:0100732)1.81624410
138Postural instability (HP:0002172)1.81186944
139Abnormality of the 1st metacarpal (HP:0010009)1.80831990
140Coronal craniosynostosis (HP:0004440)1.80360767
141Acanthocytosis (HP:0001927)1.80309144
142Exotropia (HP:0000577)1.80155503
143Hemiplegia (HP:0002301)1.79897149
144Cone-rod dystrophy (HP:0000548)1.79795280
145Facial cleft (HP:0002006)1.78843753
146Abnormality of the middle phalanges of the toes (HP:0010183)1.78700302
147Hemivertebrae (HP:0002937)1.77614616
148Molar tooth sign on MRI (HP:0002419)1.77313732
149Abnormality of midbrain morphology (HP:0002418)1.77313732
150Cutaneous syndactyly (HP:0012725)1.76951267
151Colon cancer (HP:0003003)1.76665186
152Duplication of thumb phalanx (HP:0009942)1.76257615
153Polycythemia (HP:0001901)1.76197606
154Palpitations (HP:0001962)1.75765091
155Hepatoblastoma (HP:0002884)1.74316948
156Hypercalciuria (HP:0002150)1.73461144
157Methylmalonic aciduria (HP:0012120)1.73259742
158Skin nodule (HP:0200036)1.71877504
159Aplasia involving forearm bones (HP:0009822)1.71147989
160Absent forearm bone (HP:0003953)1.71147989
161Preaxial hand polydactyly (HP:0001177)1.70477958
162Impaired social interactions (HP:0000735)1.70201041
163Abnormal social behavior (HP:0012433)1.70201041
164Abnormality of the septum pellucidum (HP:0007375)1.69762083
165Labial hypoplasia (HP:0000066)1.68918658
166Abnormal lung lobation (HP:0002101)1.68898992
167Split foot (HP:0001839)1.68398879
168Tracheomalacia (HP:0002779)1.68204280
169Abnormality of vitamin metabolism (HP:0100508)1.67430658
170Abnormality of the phalanges of the hallux (HP:0010057)1.66971251
171Congenital sensorineural hearing impairment (HP:0008527)1.66531027
172Anencephaly (HP:0002323)1.66455364
173Preaxial foot polydactyly (HP:0001841)1.66352501
174Aplasia/Hypoplasia of the patella (HP:0006498)1.66067119
175Scrotal hypoplasia (HP:0000046)1.65435600
176Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.64958602
177Sclerocornea (HP:0000647)1.64087673
178Methylmalonic acidemia (HP:0002912)1.63677619
179Abnormality of homocysteine metabolism (HP:0010919)1.63645009
180Homocystinuria (HP:0002156)1.63645009
181Stenosis of the external auditory canal (HP:0000402)1.61526395
182Oligodactyly (HP:0012165)1.61388718
183Abdominal situs inversus (HP:0003363)1.60949614
184Abnormality of abdominal situs (HP:0011620)1.60949614
185Cupped ear (HP:0000378)1.60819556
186Chronic hepatic failure (HP:0100626)1.59515870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK152.84902408
2CASK2.80627617
3MST1R2.72853237
4LMTK22.62347886
5AKT32.54292938
6EPHB22.53066303
7MST42.52384421
8FRK2.45973170
9MARK12.42802392
10MKNK22.39428133
11PNCK2.38398604
12TYRO32.31186666
13CAMK1G2.28137304
14CAMK1D2.27074602
15EPHA42.21675935
16NME12.21062625
17MAP3K42.00564477
18EPHA21.95142357
19DYRK21.89413691
20MAP3K121.83971992
21ERBB41.78042779
22ACVR1B1.74594505
23MAP2K41.70512820
24MARK21.69885085
25FGFR41.65095448
26NTRK21.62590720
27TLK11.59021427
28PIK3CA1.58864961
29FGFR21.55171213
30CDC71.49456816
31VRK11.49124892
32MAP2K71.47399161
33MINK11.46369807
34FER1.44367547
35MAP3K91.43923803
36NTRK31.42708661
37MYLK1.41648113
38TNIK1.38988752
39OXSR11.37355725
40PTK61.36668535
41BCKDK1.34796118
42BCR1.29978235
43MKNK11.29817466
44NEK21.23519579
45NUAK11.21016271
46GRK61.17822075
47STK38L1.16492675
48SIK11.16442770
49WNK31.16284167
50TTK1.12728201
51VRK21.09762736
52DAPK21.09653431
53CSNK1G21.08172896
54CSNK1G11.06800358
55NTRK11.04926435
56SIK21.04638504
57SRPK11.04197097
58KSR11.03967576
59SGK4941.02790898
60SGK2231.02790898
61ERBB21.01156844
62DMPK1.00535163
63PTK21.00386544
64PDPK10.99195956
65MAP2K20.99076897
66CAMK2B0.94680009
67PHKG20.94647381
68PHKG10.94647381
69PRKD30.93708200
70CAMK2G0.93580268
71YES10.93495652
72GRK10.91885120
73ARAF0.91100263
74RIPK10.90263527
75SGK20.88963135
76TBK10.87780634
77MAP2K10.86387686
78MAPK130.85540150
79PRKCG0.84428454
80CAMK2A0.83466186
81CSNK1G30.82044071
82MAP3K20.80856629
83PLK30.80718471
84PRKG20.79513202
85MAP3K100.79042186
86TNK20.77767019
87CAMK10.77643370
88MET0.76834286
89PDGFRA0.76653509
90CAMK2D0.75283027
91MAP2K60.74967890
92TRIM280.74587645
93KSR20.74003075
94NEK10.73708458
95CSNK1E0.73018642
96CSNK1A10.72359614
97PINK10.72354741
98SGK30.72064727
99CDK50.72056142
100PDK20.71537125
101ADRBK20.71165095
102PRKCI0.70691312
103PDK30.69265663
104PDK40.69265663
105ADRBK10.68672742
106MAP4K20.68582624
107SIK30.67003764
108STK240.65882055
109MAP3K70.64270202
110PAK30.64267788
111PRKD20.63963550
112DYRK1A0.62199077
113WNK40.61726469
114ROCK10.61606865
115CSNK1A1L0.61255665
116PDK10.60871165
117STK390.60693738
118PLK40.59746695
119TAOK20.59587702
120PKN10.59429868
121INSRR0.59157473
122AURKB0.58807960
123FGFR10.58319450
124TSSK60.57564672
125TRIB30.56865595
126PRKCE0.56219831
127RET0.54857963
128ROCK20.54320169
129CHEK20.54068052
130AURKA0.53791487
131PLK10.53208164
132BMPR1B0.53203710
133CDK30.51091947
134PRKCA0.51044135
135PRKCZ0.50398262
136NLK0.49654092
137FGR0.49642248
138TAOK10.48686126
139SRC0.48380578
140BUB10.48118148
141TAF10.47699685
142ZAK0.47019672
143PRKDC0.46595712
144BRAF0.45702653
145UHMK10.45514457
146SGK10.44454354
147PRKACG0.43746514
148LIMK10.43704661
149GRK50.43400671
150STK110.42395549
151FES0.42311053
152PRKAA10.41752524
153CDK10.40682252
154DDR20.40258892
155EEF2K0.39705165

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.73447869
2Arginine biosynthesis_Homo sapiens_hsa002202.53299409
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.43413375
4Sulfur metabolism_Homo sapiens_hsa009202.41147677
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.40490056
6Butanoate metabolism_Homo sapiens_hsa006502.36765915
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26459403
8Tryptophan metabolism_Homo sapiens_hsa003802.16675596
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.12164087
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.04148230
11Bile secretion_Homo sapiens_hsa049762.01519879
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.00038711
13Fatty acid degradation_Homo sapiens_hsa000711.94214765
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.91929283
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88412213
16Basal cell carcinoma_Homo sapiens_hsa052171.87269204
17Vitamin B6 metabolism_Homo sapiens_hsa007501.81764814
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80787510
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73901391
20Histidine metabolism_Homo sapiens_hsa003401.70362128
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65500994
22Ribosome_Homo sapiens_hsa030101.64460639
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60984417
24Pyruvate metabolism_Homo sapiens_hsa006201.54820466
25Fat digestion and absorption_Homo sapiens_hsa049751.54302678
26Nicotine addiction_Homo sapiens_hsa050331.54195520
27Propanoate metabolism_Homo sapiens_hsa006401.53493346
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48258525
29Hedgehog signaling pathway_Homo sapiens_hsa043401.47839548
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46618497
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46371075
32Fatty acid metabolism_Homo sapiens_hsa012121.41405939
33Phenylalanine metabolism_Homo sapiens_hsa003601.39841771
34Mineral absorption_Homo sapiens_hsa049781.37082250
35PPAR signaling pathway_Homo sapiens_hsa033201.36183487
36beta-Alanine metabolism_Homo sapiens_hsa004101.35423792
37Sulfur relay system_Homo sapiens_hsa041221.33513574
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33433084
39Peroxisome_Homo sapiens_hsa041461.27028565
40Linoleic acid metabolism_Homo sapiens_hsa005911.22821248
41Steroid biosynthesis_Homo sapiens_hsa001001.21933847
42Caffeine metabolism_Homo sapiens_hsa002321.21675890
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21395650
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20466443
45RNA polymerase_Homo sapiens_hsa030201.17930713
46Mismatch repair_Homo sapiens_hsa034301.13515693
47Hippo signaling pathway_Homo sapiens_hsa043901.13026193
48Huntingtons disease_Homo sapiens_hsa050161.10542662
49Chemical carcinogenesis_Homo sapiens_hsa052041.08570888
50Basal transcription factors_Homo sapiens_hsa030221.08180111
51Salivary secretion_Homo sapiens_hsa049701.08120011
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05279151
53Ether lipid metabolism_Homo sapiens_hsa005651.04928809
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.04056744
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04029280
56Complement and coagulation cascades_Homo sapiens_hsa046101.03472368
57Carbon metabolism_Homo sapiens_hsa012001.02969040
58Starch and sucrose metabolism_Homo sapiens_hsa005001.02419645
59Arginine and proline metabolism_Homo sapiens_hsa003301.02113234
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01875809
61GABAergic synapse_Homo sapiens_hsa047271.01807145
62Vitamin digestion and absorption_Homo sapiens_hsa049770.99499446
63Parkinsons disease_Homo sapiens_hsa050120.99289202
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97627783
65Synaptic vesicle cycle_Homo sapiens_hsa047210.95781657
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95095129
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94485045
68Fructose and mannose metabolism_Homo sapiens_hsa000510.94340209
69Tyrosine metabolism_Homo sapiens_hsa003500.94057102
70Biosynthesis of amino acids_Homo sapiens_hsa012300.92788232
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92468712
72Wnt signaling pathway_Homo sapiens_hsa043100.92233451
73Thyroid hormone synthesis_Homo sapiens_hsa049180.91638264
74Retinol metabolism_Homo sapiens_hsa008300.90482605
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88172006
76Homologous recombination_Homo sapiens_hsa034400.88076450
77Cardiac muscle contraction_Homo sapiens_hsa042600.86653018
78Glutamatergic synapse_Homo sapiens_hsa047240.83536418
79Phototransduction_Homo sapiens_hsa047440.83030613
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.80844216
81Glycerolipid metabolism_Homo sapiens_hsa005610.80728383
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.78040541
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76510340
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75774885
85Protein digestion and absorption_Homo sapiens_hsa049740.74082004
86Fatty acid biosynthesis_Homo sapiens_hsa000610.72638981
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72509311
88RNA degradation_Homo sapiens_hsa030180.72376168
89Arachidonic acid metabolism_Homo sapiens_hsa005900.71868921
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.70099236
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69389884
92Collecting duct acid secretion_Homo sapiens_hsa049660.69248836
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67958214
94Folate biosynthesis_Homo sapiens_hsa007900.66802815
95Long-term depression_Homo sapiens_hsa047300.66071532
96Gastric acid secretion_Homo sapiens_hsa049710.65155685
97Circadian entrainment_Homo sapiens_hsa047130.65028230
98Galactose metabolism_Homo sapiens_hsa000520.64607300
99One carbon pool by folate_Homo sapiens_hsa006700.63398433
100Melanogenesis_Homo sapiens_hsa049160.62587302
101Protein export_Homo sapiens_hsa030600.61430874
102Spliceosome_Homo sapiens_hsa030400.60799765
103Adherens junction_Homo sapiens_hsa045200.59700790
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.58876124
105Fanconi anemia pathway_Homo sapiens_hsa034600.57971703
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57799149
107Lysine degradation_Homo sapiens_hsa003100.57220914
108Base excision repair_Homo sapiens_hsa034100.56853935
109Morphine addiction_Homo sapiens_hsa050320.56485895
110Oxidative phosphorylation_Homo sapiens_hsa001900.55513822
111Dopaminergic synapse_Homo sapiens_hsa047280.55292002
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54276871
113Renin-angiotensin system_Homo sapiens_hsa046140.54025952
114Fatty acid elongation_Homo sapiens_hsa000620.53787440
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52397965
116Taste transduction_Homo sapiens_hsa047420.51967092
117ABC transporters_Homo sapiens_hsa020100.50096897
118Insulin secretion_Homo sapiens_hsa049110.48718388
119Vibrio cholerae infection_Homo sapiens_hsa051100.48698159
120Pancreatic secretion_Homo sapiens_hsa049720.47600644
121Renin secretion_Homo sapiens_hsa049240.46951786
122Amphetamine addiction_Homo sapiens_hsa050310.45016175
123Gap junction_Homo sapiens_hsa045400.44855746
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43894844
125Cocaine addiction_Homo sapiens_hsa050300.43556118
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43422147
127Long-term potentiation_Homo sapiens_hsa047200.42457499
128Glutathione metabolism_Homo sapiens_hsa004800.41590895
129Tight junction_Homo sapiens_hsa045300.38829023
130Cholinergic synapse_Homo sapiens_hsa047250.38698220
131Metabolic pathways_Homo sapiens_hsa011000.37738795
132Serotonergic synapse_Homo sapiens_hsa047260.36915906
133Axon guidance_Homo sapiens_hsa043600.33888429
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33698912
135Alzheimers disease_Homo sapiens_hsa050100.33643090
136Selenocompound metabolism_Homo sapiens_hsa004500.33579474

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