PDF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.78913576
2DNA deamination (GO:0045006)5.64902449
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.41137938
4DNA unwinding involved in DNA replication (GO:0006268)4.93619265
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.81553393
6ATP synthesis coupled proton transport (GO:0015986)4.81553393
7DNA strand elongation involved in DNA replication (GO:0006271)4.81437041
8DNA strand elongation (GO:0022616)4.74037581
9proline metabolic process (GO:0006560)4.58578611
10GDP-mannose metabolic process (GO:0019673)4.41635741
11negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.37092676
12peptidyl-arginine omega-N-methylation (GO:0035247)4.33410342
13telomere maintenance via semi-conservative replication (GO:0032201)4.26334325
14respiratory electron transport chain (GO:0022904)4.26074097
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.24720185
16electron transport chain (GO:0022900)4.21431015
17DNA replication initiation (GO:0006270)4.20430389
18oxidative phosphorylation (GO:0006119)4.14140878
19quinone biosynthetic process (GO:1901663)4.08112650
20ubiquinone biosynthetic process (GO:0006744)4.08112650
21ribosome assembly (GO:0042255)4.00545003
22regulation of mitochondrial translation (GO:0070129)3.97226106
23L-phenylalanine metabolic process (GO:0006558)3.89804192
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.89804192
25branched-chain amino acid catabolic process (GO:0009083)3.87986694
26histone arginine methylation (GO:0034969)3.86517364
27formation of translation preinitiation complex (GO:0001731)3.79416360
28ribosome biogenesis (GO:0042254)3.76241884
29respiratory chain complex IV assembly (GO:0008535)3.76148856
30nucleobase-containing small molecule interconversion (GO:0015949)3.72913768
31regulation of mammary gland epithelial cell proliferation (GO:0033599)3.72118027
32regulation of translational fidelity (GO:0006450)3.65914957
33chaperone-mediated protein transport (GO:0072321)3.65451812
34pseudouridine synthesis (GO:0001522)3.63789825
35negative regulation of mRNA processing (GO:0050686)3.63384597
36iron-sulfur cluster assembly (GO:0016226)3.61565561
37metallo-sulfur cluster assembly (GO:0031163)3.61565561
38regulation of translational termination (GO:0006449)3.61515576
39L-phenylalanine catabolic process (GO:0006559)3.58714962
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.58714962
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.55419409
42NADH dehydrogenase complex assembly (GO:0010257)3.55419409
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55419409
44mitotic chromosome condensation (GO:0007076)3.51535755
45L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.49940463
46peptidyl-arginine N-methylation (GO:0035246)3.49819763
47peptidyl-arginine methylation (GO:0018216)3.49819763
48L-methionine salvage (GO:0071267)3.49446966
49L-methionine biosynthetic process (GO:0071265)3.49446966
50amino acid salvage (GO:0043102)3.49446966
51oxaloacetate metabolic process (GO:0006107)3.48554117
52DNA replication checkpoint (GO:0000076)3.46952305
53branched-chain amino acid metabolic process (GO:0009081)3.45687108
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.45303800
55telomere maintenance via recombination (GO:0000722)3.43601912
56rRNA transcription (GO:0009303)3.43070570
57valine metabolic process (GO:0006573)3.42793020
58mitochondrial respiratory chain complex assembly (GO:0033108)3.40552182
59glycine metabolic process (GO:0006544)3.38230118
60ubiquinone metabolic process (GO:0006743)3.38095970
61inner mitochondrial membrane organization (GO:0007007)3.38014398
62lysine catabolic process (GO:0006554)3.37650872
63lysine metabolic process (GO:0006553)3.37650872
64protein complex biogenesis (GO:0070271)3.37428856
65cytochrome complex assembly (GO:0017004)3.37228568
66negative regulation of mRNA metabolic process (GO:1903312)3.34706119
67ribonucleoprotein complex biogenesis (GO:0022613)3.34055777
68spliceosomal tri-snRNP complex assembly (GO:0000244)3.34052791
69DNA strand renaturation (GO:0000733)3.29470432
70tricarboxylic acid cycle (GO:0006099)3.27680753
71heterochromatin organization (GO:0070828)3.26175513
72pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.25170980
73viral mRNA export from host cell nucleus (GO:0046784)3.23411653
74cysteine metabolic process (GO:0006534)3.23347339
752-oxoglutarate metabolic process (GO:0006103)3.23295409
76serine family amino acid biosynthetic process (GO:0009070)3.22727254
77nuclear envelope reassembly (GO:0031468)3.21857299
78mitotic nuclear envelope reassembly (GO:0007084)3.21857299
79pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.20569055
80mitotic recombination (GO:0006312)3.19782011
81NADH metabolic process (GO:0006734)3.19767901
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17335499
83negative regulation of cell size (GO:0045792)3.16674201
84folic acid-containing compound biosynthetic process (GO:0009396)3.15818128
85establishment of integrated proviral latency (GO:0075713)3.14615196
86COPI coating of Golgi vesicle (GO:0048205)3.14414149
87Golgi transport vesicle coating (GO:0048200)3.14414149
88aromatic amino acid family catabolic process (GO:0009074)3.13764796
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12235714
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12235714
91negative regulation of RNA splicing (GO:0033119)3.12042497
92pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.11673053
93cellular ketone body metabolic process (GO:0046950)3.09584423
94transcription from mitochondrial promoter (GO:0006390)3.09288441
95pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.07271636
96glyoxylate metabolic process (GO:0046487)3.07095888
97base-excision repair (GO:0006284)3.05278822
98maturation of SSU-rRNA (GO:0030490)3.05192262
99proteasome assembly (GO:0043248)3.04891988
100ribosomal small subunit assembly (GO:0000028)3.04429706
101mitochondrial DNA metabolic process (GO:0032042)3.03956864
102nucleobase biosynthetic process (GO:0046112)3.03304583
103DNA duplex unwinding (GO:0032508)3.01070538
104negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.00723480
105purine nucleotide salvage (GO:0032261)2.99614369
106base-excision repair, AP site formation (GO:0006285)2.98349226
107kynurenine metabolic process (GO:0070189)2.98147470
108amino-acid betaine metabolic process (GO:0006577)2.97593085
109serine family amino acid metabolic process (GO:0009069)2.97320289
110tRNA methylation (GO:0030488)2.95347410
111ncRNA 3-end processing (GO:0043628)2.95105892
112pentose metabolic process (GO:0019321)2.94711100
113L-serine metabolic process (GO:0006563)2.93431816
114purine nucleobase biosynthetic process (GO:0009113)2.93407142
115deoxyribose phosphate biosynthetic process (GO:0046385)2.93006836
1162-deoxyribonucleotide biosynthetic process (GO:0009265)2.93006836
117aspartate family amino acid catabolic process (GO:0009068)2.92738292
118galactose catabolic process (GO:0019388)2.91790538
119nucleotide-excision repair, DNA gap filling (GO:0006297)2.91775623
120triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.91602142
121tryptophan catabolic process (GO:0006569)2.91286264
122indole-containing compound catabolic process (GO:0042436)2.91286264
123indolalkylamine catabolic process (GO:0046218)2.91286264
124rRNA processing (GO:0006364)2.91193656
125guanosine-containing compound biosynthetic process (GO:1901070)2.90313300
126biotin metabolic process (GO:0006768)2.90298451
127succinate metabolic process (GO:0006105)2.90249841
128fatty acid beta-oxidation (GO:0006635)2.89407929
129cellular metabolic compound salvage (GO:0043094)2.88259343
130protein targeting to mitochondrion (GO:0006626)2.88250226
131aspartate family amino acid metabolic process (GO:0009066)2.88073559
132protein localization to chromosome, centromeric region (GO:0071459)2.88044670
133negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.87618646
134UTP biosynthetic process (GO:0006228)2.87292110
135aldehyde catabolic process (GO:0046185)2.86832382
136short-chain fatty acid metabolic process (GO:0046459)2.85895565
137glutamine family amino acid biosynthetic process (GO:0009084)2.85602907
138deoxyribonucleotide biosynthetic process (GO:0009263)2.84783588
139pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.84494101
140telomere maintenance via telomere lengthening (GO:0010833)2.84043079
141sulfur amino acid biosynthetic process (GO:0000097)2.83863663
142purine-containing compound salvage (GO:0043101)2.83750150
143IMP biosynthetic process (GO:0006188)2.83516128
144ethanol oxidation (GO:0006069)2.83356660
145establishment of protein localization to mitochondrial membrane (GO:0090151)2.83210298
146DNA geometric change (GO:0032392)2.81585339
147aerobic respiration (GO:0009060)2.81407948
148methionine metabolic process (GO:0006555)2.81348847
149fatty acid catabolic process (GO:0009062)2.81243600
150regulation of cellular respiration (GO:0043457)2.81083048
151mitochondrial RNA metabolic process (GO:0000959)2.79529718
152tRNA modification (GO:0006400)2.78904001
153pentose-phosphate shunt (GO:0006098)2.78736243
154protein complex localization (GO:0031503)2.78315100
155negative regulation of cell aging (GO:0090344)2.77991368
156NAD metabolic process (GO:0019674)2.77652276
157chromatin assembly (GO:0031497)2.77292696
158peptidyl-histidine modification (GO:0018202)2.77038009
159S-adenosylmethionine metabolic process (GO:0046500)2.75733100
160killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.75305141
161disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.75305141
162rRNA metabolic process (GO:0016072)2.74111133
163pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.73766147
164ribosomal small subunit biogenesis (GO:0042274)2.73667804
165monocarboxylic acid catabolic process (GO:0072329)2.72608356
166quinone metabolic process (GO:1901661)2.72565490
167alpha-amino acid catabolic process (GO:1901606)2.72469912
168bile acid biosynthetic process (GO:0006699)2.72357534
169tryptophan metabolic process (GO:0006568)2.71752699
170protein maturation by protein folding (GO:0022417)2.70183727
171translesion synthesis (GO:0019985)2.69810221
172IMP metabolic process (GO:0046040)2.69239020
173folic acid metabolic process (GO:0046655)2.68783971
174establishment of protein localization to mitochondrion (GO:0072655)2.68698773
175nucleotide salvage (GO:0043173)2.68390906
176termination of RNA polymerase II transcription (GO:0006369)2.67489167
177coenzyme catabolic process (GO:0009109)2.67369020
178nucleoside salvage (GO:0043174)2.67267006
179DNA replication-dependent nucleosome assembly (GO:0006335)2.67173689
180DNA replication-dependent nucleosome organization (GO:0034723)2.67173689
181NAD biosynthetic process (GO:0009435)2.66672685
182carnitine metabolic process (GO:0009437)2.66335485
183UV protection (GO:0009650)2.66194685
184establishment of viral latency (GO:0019043)2.65554204
185regulation of cellular amino acid metabolic process (GO:0006521)2.65036785
186mitochondrial fusion (GO:0008053)2.63872774
187folic acid-containing compound metabolic process (GO:0006760)2.62671415
188mitotic sister chromatid segregation (GO:0000070)2.57893750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.67845044
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.37626761
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.06287993
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.97628607
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.67809137
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66337253
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.38755757
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.24806200
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.09833878
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02595535
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.93258859
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.82131732
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82025453
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.77689729
15VDR_21846776_ChIP-Seq_THP-1_Human2.73000883
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62947010
17MYC_22102868_ChIP-Seq_BL_Human2.61383075
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.60421597
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60345833
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.54729326
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.51016998
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.45353164
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.39141397
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35820175
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.25968484
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.25706031
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24122614
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23681523
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.23628820
30DCP1A_22483619_ChIP-Seq_HELA_Human2.19943800
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15928835
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14590801
33FOXM1_23109430_ChIP-Seq_U2OS_Human2.06714289
34XRN2_22483619_ChIP-Seq_HELA_Human2.03917389
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97362231
36VDR_23849224_ChIP-Seq_CD4+_Human1.94921242
37GATA1_22025678_ChIP-Seq_K562_Human1.92536261
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.90180342
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87769928
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87606485
41LXR_22292898_ChIP-Seq_THP-1_Human1.85793862
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85495409
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.83967734
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.82925667
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80946172
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.79844480
47* GABP_19822575_ChIP-Seq_HepG2_Human1.77326178
48FOXP3_21729870_ChIP-Seq_TREG_Human1.76015329
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74375270
50* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.69849133
51E2F7_22180533_ChIP-Seq_HELA_Human1.69080504
52ZNF263_19887448_ChIP-Seq_K562_Human1.69052864
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68826746
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68279223
55* RACK7_27058665_Chip-Seq_MCF-7_Human1.62824976
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.61058975
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58633399
58* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56326798
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53313037
60P68_20966046_ChIP-Seq_HELA_Human1.53082736
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52989617
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.52653619
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50058863
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49937202
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47894901
66LXR_22158963_ChIP-Seq_LIVER_Mouse1.47330359
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47262087
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46460514
69KDM5A_27292631_Chip-Seq_BREAST_Human1.45635579
70* TTF2_22483619_ChIP-Seq_HELA_Human1.44131158
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40304821
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.38654341
73* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.38283946
74* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32195175
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31517605
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31215675
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30423587
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28472992
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27688653
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27647067
81MAF_26560356_Chip-Seq_TH2_Human1.27169265
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.26809697
83E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25749575
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23659356
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22563553
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.19537588
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18946172
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17945457
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.17764606
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17604658
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.17261946
92KDM2B_26808549_Chip-Seq_DND41_Human1.17030454
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15549403
94MAF_26560356_Chip-Seq_TH1_Human1.15530395
95CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14695670
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12853622
97CIITA_25753668_ChIP-Seq_RAJI_Human1.10228860
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09969021
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09852693
100ATF3_27146783_Chip-Seq_COLON_Human1.09028033
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07762892
102CTCF_21964334_Chip-Seq_Bcells_Human1.07449216
103KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07075772
104SA1_27219007_Chip-Seq_ERYTHROID_Human1.06169043
105BCOR_27268052_Chip-Seq_Bcells_Human1.05474622
106MYC_18940864_ChIP-ChIP_HL60_Human1.05442596
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03507983
108TFEB_21752829_ChIP-Seq_HELA_Human1.03490453
109AR_21909140_ChIP-Seq_LNCAP_Human1.03310347
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03095355
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02822163
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01586223
113VDR_24763502_ChIP-Seq_THP-1_Human1.01080097
114NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99981527
115EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98028391
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96321095
117LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95565997
118STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95235943
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93369168
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93185153
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91975900
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91516227
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91056898
124PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90757850
125TET1_21451524_ChIP-Seq_MESCs_Mouse0.86982726
126ELK1_22589737_ChIP-Seq_MCF10A_Human0.84625338
127FOXP1_21924763_ChIP-Seq_HESCs_Human0.84181976
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83902625
129SPI1_23547873_ChIP-Seq_NB4_Human0.83695197
130ELK1_19687146_ChIP-ChIP_HELA_Human0.83331028
131TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83058071
132IRF1_19129219_ChIP-ChIP_H3396_Human0.82366931
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82045061
134BCL6_27268052_Chip-Seq_Bcells_Human0.81392745
135SCL_19346495_ChIP-Seq_HPC-7_Human0.81165692
136STAT1_20625510_ChIP-Seq_HELA_Human0.78793212
137NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.78096147
138RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.77817425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.75060048
2MP0003806_abnormal_nucleotide_metabolis4.25480689
3MP0003111_abnormal_nucleus_morphology4.14275575
4MP0005365_abnormal_bile_salt3.68818875
5MP0005360_urolithiasis3.64702779
6MP0005085_abnormal_gallbladder_physiolo3.31942593
7MP0003646_muscle_fatigue3.24155331
8MP0006036_abnormal_mitochondrial_physio3.18531666
9MP0009278_abnormal_bone_marrow3.05964694
10MP0004185_abnormal_adipocyte_glucose2.98902625
11MP0003077_abnormal_cell_cycle2.95903655
12MP0008875_abnormal_xenobiotic_pharmacok2.84978482
13MP0003195_calcinosis2.84562059
14MP0002837_dystrophic_cardiac_calcinosis2.79647851
15MP0009840_abnormal_foam_cell2.64592586
16MP0009697_abnormal_copulation2.60983314
17MP0003186_abnormal_redox_activity2.51490924
18MP0006035_abnormal_mitochondrial_morpho2.49531807
19MP0002877_abnormal_melanocyte_morpholog2.45636725
20MP0008932_abnormal_embryonic_tissue2.42036427
21MP0005076_abnormal_cell_differentiation2.41971719
22MP0005332_abnormal_amino_acid2.36605597
23MP0001661_extended_life_span2.31323797
24MP0003705_abnormal_hypodermis_morpholog2.28367828
25MP0005501_abnormal_skin_physiology2.28280921
26MP0010234_abnormal_vibrissa_follicle2.22777363
27MP0004233_abnormal_muscle_weight2.21895264
28MP0000749_muscle_degeneration2.07489156
29MP0005083_abnormal_biliary_tract2.05570777
30MP0004215_abnormal_myocardial_fiber2.03913110
31MP0005319_abnormal_enzyme/_coenzyme2.01209129
32MP0009379_abnormal_foot_pigmentation1.90166992
33MP0004036_abnormal_muscle_relaxation1.89673443
34MP0002796_impaired_skin_barrier1.87847748
35MP0001666_abnormal_nutrient_absorption1.87027285
36MP0005058_abnormal_lysosome_morphology1.85619899
37MP0010329_abnormal_lipoprotein_level1.85575356
38MP0000350_abnormal_cell_proliferation1.82364589
39MP0001730_embryonic_growth_arrest1.81376715
40MP0001853_heart_inflammation1.79925074
41MP0005584_abnormal_enzyme/coenzyme_acti1.78090130
42MP0001764_abnormal_homeostasis1.75919583
43MP0000751_myopathy1.72714256
44MP0000678_abnormal_parathyroid_gland1.71998617
45MP0005330_cardiomyopathy1.71896534
46MP0004084_abnormal_cardiac_muscle1.68032475
47MP0000490_abnormal_crypts_of1.63813307
48MP0001188_hyperpigmentation1.56316126
49MP0003453_abnormal_keratinocyte_physiol1.51812788
50MP0002080_prenatal_lethality1.51642250
51MP0003724_increased_susceptibility_to1.48495027
52MP0009643_abnormal_urine_homeostasis1.46783281
53MP0008007_abnormal_cellular_replicative1.46382172
54MP0003693_abnormal_embryo_hatching1.45314655
55MP0005266_abnormal_metabolism1.43607322
56MP0009333_abnormal_splenocyte_physiolog1.42638654
57MP0000747_muscle_weakness1.41157489
58MP0001346_abnormal_lacrimal_gland1.41039032
59MP0002269_muscular_atrophy1.40767131
60MP0004147_increased_porphyrin_level1.38234599
61MP0003786_premature_aging1.37844673
62MP0000313_abnormal_cell_death1.37211345
63MP0005380_embryogenesis_phenotype1.35741323
64MP0001672_abnormal_embryogenesis/_devel1.35741323
65MP0002019_abnormal_tumor_incidence1.35412211
66MP0005171_absent_coat_pigmentation1.34982372
67MP0005666_abnormal_adipose_tissue1.34175720
68MP0005397_hematopoietic_system_phenotyp1.34142882
69MP0001545_abnormal_hematopoietic_system1.34142882
70MP0000609_abnormal_liver_physiology1.33856592
71MP0005623_abnormal_meninges_morphology1.32447629
72MP0005451_abnormal_body_composition1.31494666
73MP0008469_abnormal_protein_level1.28347212
74MP0002118_abnormal_lipid_homeostasis1.28293056
75MP0001697_abnormal_embryo_size1.26177051
76MP0002396_abnormal_hematopoietic_system1.25637565
77MP0002160_abnormal_reproductive_system1.25587597
78MP0004858_abnormal_nervous_system1.24951016
79MP0005636_abnormal_mineral_homeostasis1.23405478
80MP0005084_abnormal_gallbladder_morpholo1.23313653
81MP0001529_abnormal_vocalization1.23234408
82MP0000750_abnormal_muscle_regeneration1.23134778
83MP0003984_embryonic_growth_retardation1.23064996
84MP0009764_decreased_sensitivity_to1.20206073
85MP0003221_abnormal_cardiomyocyte_apopto1.19973801
86MP0003011_delayed_dark_adaptation1.19901042
87MP0002088_abnormal_embryonic_growth/wei1.17520046
88MP0004130_abnormal_muscle_cell1.17133337
89MP0002132_abnormal_respiratory_system1.16514544
90MP0000003_abnormal_adipose_tissue1.14909639
91MP0004808_abnormal_hematopoietic_stem1.14081080
92MP0004957_abnormal_blastocyst_morpholog1.13720439
93MP0010307_abnormal_tumor_latency1.13414002
94MP0003191_abnormal_cellular_cholesterol1.13204825
95MP0000343_altered_response_to1.12539084
96MP0001881_abnormal_mammary_gland1.10874208
97MP0002106_abnormal_muscle_physiology1.09811047
98MP0001849_ear_inflammation1.09082240
99MP0005670_abnormal_white_adipose1.08720579
100MP0005375_adipose_tissue_phenotype1.07602812
101MP0009785_altered_susceptibility_to1.07453560
102MP0010368_abnormal_lymphatic_system1.07379849
103MP0005376_homeostasis/metabolism_phenot1.07316297
104MP0002163_abnormal_gland_morphology1.06042534
105MP0004145_abnormal_muscle_electrophysio1.04072408
106MP0000537_abnormal_urethra_morphology1.03742082
107MP0000358_abnormal_cell_content/1.03703781
108MP0003315_abnormal_perineum_morphology1.03594634
109MP0002249_abnormal_larynx_morphology1.03569364
110MP0009672_abnormal_birth_weight1.03131157
111MP0010030_abnormal_orbit_morphology1.02903424
112MP0005621_abnormal_cell_physiology1.02146121
113MP0003656_abnormal_erythrocyte_physiolo0.99778832
114MP0004197_abnormal_fetal_growth/weight/0.97542687
115MP0009931_abnormal_skin_appearance0.97212431
116MP0001873_stomach_inflammation0.96743698
117MP0002060_abnormal_skin_morphology0.96302298
118MP0002086_abnormal_extraembryonic_tissu0.96231644
119MP0002085_abnormal_embryonic_tissue0.95601044
120MP0002638_abnormal_pupillary_reflex0.95561553
121MP0005384_cellular_phenotype0.95140247
122MP0005535_abnormal_body_temperature0.94124243
123MP0002332_abnormal_exercise_endurance0.94060251
124MP0005647_abnormal_sex_gland0.89682111
125MP0003763_abnormal_thymus_physiology0.89681699
126MP0004782_abnormal_surfactant_physiolog0.89654228
127MP0000681_abnormal_thyroid_gland0.89317668
128MP0001727_abnormal_embryo_implantation0.88738744
129MP0003123_paternal_imprinting0.88347304
130MP0008260_abnormal_autophagy0.87894524
131MP0000598_abnormal_liver_morphology0.86675369
132MP0005385_cardiovascular_system_phenoty0.86043247
133MP0001544_abnormal_cardiovascular_syste0.86043247
134MP0010771_integument_phenotype0.85859065
135MP0000858_altered_metastatic_potential0.85841986
136MP0001216_abnormal_epidermal_layer0.85571369
137MP0002090_abnormal_vision0.84821844
138MP0003137_abnormal_impulse_conducting0.84337945
139MP0005620_abnormal_muscle_contractility0.84170175
140MP0009763_increased_sensitivity_to0.84139928
141MP0009642_abnormal_blood_homeostasis0.83938581
142MP0005165_increased_susceptibility_to0.83446446
143MP0000703_abnormal_thymus_morphology0.82452857
144MP0008058_abnormal_DNA_repair0.81290420
145MP0005220_abnormal_exocrine_pancreas0.80372515
146MP0005257_abnormal_intraocular_pressure0.78295577
147MP0005075_abnormal_melanosome_morpholog0.77553933
148MP0004087_abnormal_muscle_fiber0.77399368
149MP0002089_abnormal_postnatal_growth/wei0.77278534
150MP0004043_abnormal_pH_regulation0.75559256
151MP0002148_abnormal_hypersensitivity_rea0.75249229
152MP0005025_abnormal_response_to0.74428901
153MP0005369_muscle_phenotype0.73542690
154MP0005464_abnormal_platelet_physiology0.73513493
155MP0000230_abnormal_systemic_arterial0.72189366
156MP0003718_maternal_effect0.71431217
157MP0010094_abnormal_chromosome_stability0.70876240
158MP0002098_abnormal_vibrissa_morphology0.70714558
159MP0002084_abnormal_developmental_patter0.70309928
160MP0002972_abnormal_cardiac_muscle0.69701680
161MP0003868_abnormal_feces_composition0.69688969
162MP0002078_abnormal_glucose_homeostasis0.69178192
163MP0003252_abnormal_bile_duct0.68834168
164MP0001919_abnormal_reproductive_system0.68705066
165MP0001879_abnormal_lymphatic_vessel0.68253929
166MP0002398_abnormal_bone_marrow0.67233701
167MP0003436_decreased_susceptibility_to0.66831655
168MP0000759_abnormal_skeletal_muscle0.66612695
169MP0004019_abnormal_vitamin_homeostasis0.66458290
170MP0001756_abnormal_urination0.66071237
171MP0008775_abnormal_heart_ventricle0.65766410
172MP0002234_abnormal_pharynx_morphology0.65611885
173MP0001348_abnormal_lacrimal_gland0.65413853
174MP0000477_abnormal_intestine_morphology0.64901923
175MP0001905_abnormal_dopamine_level0.64802458
176MP0001845_abnormal_inflammatory_respons0.63229735
177MP0006054_spinal_hemorrhage0.61724227
178MP0008057_abnormal_DNA_replication0.61337490
179MP0003567_abnormal_fetal_cardiomyocyte0.61275867

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.69913580
2Hepatocellular necrosis (HP:0001404)4.60146780
3Testicular atrophy (HP:0000029)4.51888702
4Mitochondrial inheritance (HP:0001427)4.19385496
5Acute encephalopathy (HP:0006846)4.10593462
6Acute necrotizing encephalopathy (HP:0006965)4.08564670
7Abnormal mitochondria in muscle tissue (HP:0008316)4.05709477
8Abnormality of aromatic amino acid family metabolism (HP:0004338)3.91608077
9Increased CSF lactate (HP:0002490)3.85990752
10Cerebral edema (HP:0002181)3.78736107
11Hyperglycinuria (HP:0003108)3.67778490
12Dicarboxylic aciduria (HP:0003215)3.64732625
13Abnormality of dicarboxylic acid metabolism (HP:0010995)3.64732625
14Lactic acidosis (HP:0003128)3.63428379
15Ulnar bowing (HP:0003031)3.62659844
16Hyperacusis (HP:0010780)3.55528425
17Ketoacidosis (HP:0001993)3.53882604
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.53427175
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.53427175
20Microvesicular hepatic steatosis (HP:0001414)3.51431651
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.42828441
22Increased intramyocellular lipid droplets (HP:0012240)3.40947429
23Ketosis (HP:0001946)3.40810365
24Increased muscle lipid content (HP:0009058)3.36387634
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.34000736
263-Methylglutaconic aciduria (HP:0003535)3.29910273
27Increased serum lactate (HP:0002151)3.28571852
28Rhabdomyolysis (HP:0003201)3.27915151
29Abnormal number of erythroid precursors (HP:0012131)3.27618791
30Abnormality of fatty-acid metabolism (HP:0004359)3.25020178
31Hyperammonemia (HP:0001987)3.22754528
32Exercise intolerance (HP:0003546)3.21221991
33Lipid accumulation in hepatocytes (HP:0006561)3.20239701
34Hypoglycemic coma (HP:0001325)3.19703486
35Abnormality of cells of the erythroid lineage (HP:0012130)3.11970302
36Lethargy (HP:0001254)3.10453742
37Squamous cell carcinoma (HP:0002860)3.05166384
38Progressive macrocephaly (HP:0004481)3.02044089
39Increased hepatocellular lipid droplets (HP:0006565)3.01685419
40Abnormality of serine family amino acid metabolism (HP:0010894)2.97327338
41Abnormality of glycine metabolism (HP:0010895)2.97327338
42Abnormality of alanine metabolism (HP:0010916)2.96859972
43Hyperalaninemia (HP:0003348)2.96859972
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.96859972
45Poikiloderma (HP:0001029)2.95338215
46Vaginal fistula (HP:0004320)2.92413522
47Prolonged partial thromboplastin time (HP:0003645)2.90869001
48Abnormality of glycolysis (HP:0004366)2.90667959
49Increased serum pyruvate (HP:0003542)2.90667959
50Myoglobinuria (HP:0002913)2.88169318
51Intrahepatic cholestasis (HP:0001406)2.86584986
52Birth length less than 3rd percentile (HP:0003561)2.84221840
53Generalized aminoaciduria (HP:0002909)2.83962618
54Hyperlipoproteinemia (HP:0010980)2.83258188
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.82279664
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.80030605
57Achilles tendon contracture (HP:0001771)2.78507936
58Progressive muscle weakness (HP:0003323)2.75824110
59Ragged-red muscle fibers (HP:0003200)2.74484157
60Renal Fanconi syndrome (HP:0001994)2.70041595
61Microretrognathia (HP:0000308)2.69788588
62Metabolic acidosis (HP:0001942)2.68899140
63Nausea (HP:0002018)2.68624256
64Xanthomatosis (HP:0000991)2.67206523
65Respiratory failure (HP:0002878)2.65433804
66Hyperglycinemia (HP:0002154)2.61287571
67Rectal fistula (HP:0100590)2.59141540
68Rectovaginal fistula (HP:0000143)2.59141540
69Insomnia (HP:0100785)2.56580065
70Oral leukoplakia (HP:0002745)2.55594643
71Delayed CNS myelination (HP:0002188)2.54988541
72Abnormality of the umbilical cord (HP:0010881)2.54689993
73CNS demyelination (HP:0007305)2.49902277
74Abnormality of monocarboxylic acid metabolism (HP:0010996)2.48592594
75Reduced antithrombin III activity (HP:0001976)2.47162289
76Myopathic facies (HP:0002058)2.46599399
77Methylmalonic aciduria (HP:0012120)2.45076458
78Overriding aorta (HP:0002623)2.44883745
79Abnormalities of placenta or umbilical cord (HP:0001194)2.44033939
80Abnormality of the Achilles tendon (HP:0005109)2.42454471
81Abnormality of serum amino acid levels (HP:0003112)2.41201880
82Intestinal fistula (HP:0100819)2.41147991
83Breast hypoplasia (HP:0003187)2.40297610
84Hypobetalipoproteinemia (HP:0003563)2.38377881
85Respiratory difficulties (HP:0002880)2.37885274
86Rib fusion (HP:0000902)2.36943638
87Exercise-induced myalgia (HP:0003738)2.36365470
88Chromosomal breakage induced by crosslinking agents (HP:0003221)2.36070118
89Gout (HP:0001997)2.33446132
90Broad distal phalanx of finger (HP:0009836)2.32513611
91Palpitations (HP:0001962)2.31522559
92IgM deficiency (HP:0002850)2.30089654
93Facial hemangioma (HP:0000329)2.28041824
94Vomiting (HP:0002013)2.26128128
95Multiple enchondromatosis (HP:0005701)2.24811265
96Late onset (HP:0003584)2.24555742
97Abnormality of the intrinsic pathway (HP:0010989)2.23574142
98Thin bony cortex (HP:0002753)2.21553739
99Abnormality of pyrimidine metabolism (HP:0004353)2.20997064
100Elfin facies (HP:0004428)2.20880650
101Abnormality of urine glucose concentration (HP:0011016)2.19263428
102Glycosuria (HP:0003076)2.19263428
103Joint hemorrhage (HP:0005261)2.16113090
104Selective tooth agenesis (HP:0001592)2.15958104
105Brushfield spots (HP:0001088)2.15636975
106Exertional dyspnea (HP:0002875)2.15095867
107Trismus (HP:0000211)2.14397601
108Rough bone trabeculation (HP:0100670)2.13830006
109Muscle stiffness (HP:0003552)2.13201139
110Abnormal trabecular bone morphology (HP:0100671)2.11982145
111Single umbilical artery (HP:0001195)2.11899600
112Abnormality of the fetal cardiovascular system (HP:0010948)2.11899600
113Abnormal umbilical cord blood vessels (HP:0011403)2.11899600
114Reticulocytopenia (HP:0001896)2.09983564
115Hyperbilirubinemia (HP:0002904)2.09912252
116Septate vagina (HP:0001153)2.09807776
117Increased serum ferritin (HP:0003281)2.04609835
118Progressive external ophthalmoplegia (HP:0000590)2.03857113
119Cholelithiasis (HP:0001081)2.02240492
120Amniotic constriction ring (HP:0009775)2.00715008
121Abnormality of placental membranes (HP:0011409)2.00715008
122Conjugated hyperbilirubinemia (HP:0002908)1.99897650
123Abnormality of methionine metabolism (HP:0010901)1.98492252
124Optic disc pallor (HP:0000543)1.97473815
125Back pain (HP:0003418)1.97210773
126Capillary hemangiomas (HP:0005306)1.96835171
127Abnormality of the heme biosynthetic pathway (HP:0010472)1.95806436
128Emotional lability (HP:0000712)1.94967279
129Abnormality of the common coagulation pathway (HP:0010990)1.93406819
130Absent thumb (HP:0009777)1.93063028
131Exercise-induced muscle cramps (HP:0003710)1.92730287
132Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92687619
133Vertebral compression fractures (HP:0002953)1.91219939
134Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.91076256
135Gliosis (HP:0002171)1.90234780
136Premature ovarian failure (HP:0008209)1.89994314
137Dysautonomia (HP:0002459)1.89943976
138Rectal prolapse (HP:0002035)1.89049340
139Hemorrhage of the eye (HP:0011885)1.88929624
140Chromsome breakage (HP:0040012)1.88523265
141Proximal tubulopathy (HP:0000114)1.87412664
142Renal duplication (HP:0000075)1.86338090
143Hypolipoproteinemia (HP:0010981)1.86226564
144Pancytopenia (HP:0001876)1.85248075
145Abnormal protein glycosylation (HP:0012346)1.84482518
146Abnormal glycosylation (HP:0012345)1.84482518
147Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84482518
148Abnormal protein N-linked glycosylation (HP:0012347)1.84482518
149Type I transferrin isoform profile (HP:0003642)1.84482063
150Abnormality of nucleobase metabolism (HP:0010932)1.83208830
151Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.81345299
152Long palpebral fissure (HP:0000637)1.80595456
153Patellar aplasia (HP:0006443)1.79868319
154Bile duct proliferation (HP:0001408)1.79504705
155Abnormal biliary tract physiology (HP:0012439)1.79504705
156Aplasia/Hypoplasia of the patella (HP:0006498)1.79280738
157Secondary amenorrhea (HP:0000869)1.79273022
158Bulbar palsy (HP:0001283)1.76668621
159Annular pancreas (HP:0001734)1.76492036
160Dyschromatopsia (HP:0007641)1.74584110
161Unilateral renal agenesis (HP:0000122)1.74554552
162Abnormality of the distal phalanges of the toes (HP:0010182)1.74451497
163Self-mutilation (HP:0000742)1.74442493
164Atrioventricular block (HP:0001678)1.73707498
165Hypertensive crisis (HP:0100735)1.73237359
166Patellar dislocation (HP:0002999)1.73010607
167Aplasia of the musculature (HP:0100854)1.70368186
168Bowing of the arm (HP:0006488)1.70297259
169Bowed forearm bones (HP:0003956)1.70297259
170Abnormality of the gallbladder (HP:0005264)1.69583624
171Truncus arteriosus (HP:0001660)1.68428732
172Absent radius (HP:0003974)1.67626068
173Nonimmune hydrops fetalis (HP:0001790)1.66752163
174Premature skin wrinkling (HP:0100678)1.66615613
175Abnormal gallbladder morphology (HP:0012437)1.65149832
176Cerebral hypomyelination (HP:0006808)1.64924030
177Turricephaly (HP:0000262)1.64814196
178Hypoparathyroidism (HP:0000829)1.64063233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.04563278
2STK164.59392305
3SMG13.92584626
4NME23.52606502
5BUB12.83965854
6VRK22.54236204
7WEE12.36326016
8EEF2K2.29927054
9KDR2.20911407
10ARAF2.07718524
11PIM22.02298836
12TNIK1.93694364
13ACVR1B1.88023393
14NME11.86867577
15VRK11.73808556
16BRSK21.66306582
17EIF2AK11.60330427
18OBSCN1.58163122
19PRPF4B1.56292673
20ERN11.55670477
21CDK121.53223462
22MYLK1.51843476
23DYRK31.50087106
24CCNB11.49613738
25EIF2AK31.48738365
26MAP3K121.47279588
27MAP3K111.45481509
28MAP3K101.45324622
29SIK11.44206330
30PINK11.43210421
31EPHA21.42985775
32MUSK1.37261216
33CDK71.36847762
34MAP4K11.34067566
35CHEK21.33987900
36NEK11.32088721
37TTK1.31528516
38MAPKAPK31.30328713
39SCYL21.27972968
40FLT31.26974434
41ICK1.26385583
42PHKG21.26033831
43PHKG11.26033831
44MAP2K31.24141492
45CDK41.24030954
46PDK41.22490063
47PDK31.22490063
48TAF11.22196197
49GRK61.16344766
50IRAK41.14658347
51TGFBR11.13942212
52RIPK41.11774143
53TEC1.11670527
54TIE11.10035866
55BLK1.09551629
56KIT1.09100605
57TLK11.07529960
58BRSK11.05773699
59TAOK21.05460469
60PKN21.05432588
61IRAK21.03969812
62CDK191.03760983
63MAPK121.00342534
64PBK0.99321746
65ILK0.98600469
66RAF10.98054139
67MAP3K50.96365955
68TYK20.95423934
69TTN0.94870261
70IRAK30.93963418
71INSRR0.92722953
72PIK3CG0.92559170
73MAP3K130.90981296
74TESK20.90330218
75TRIB30.90031988
76PAK40.88350468
77MAP3K80.86328288
78MAP2K60.84358472
79SRPK10.84155676
80TBK10.83932342
81BRAF0.83615977
82MAP3K140.81973508
83MTOR0.81655304
84CDK80.81120164
85PDK20.80322028
86ZAP700.78195988
87MAPK150.77941743
88ABL20.76786652
89AKT20.76777537
90BTK0.76471112
91CHEK10.74124088
92ADRBK20.72612511
93AURKA0.71093976
94MAP3K30.70956703
95MAP2K70.69804340
96PRKD30.68232143
97MST1R0.67764844
98GRK70.67642918
99STK40.67507844
100TESK10.66962110
101MAPK110.65362475
102PRKD20.64308850
103MAPK40.63066637
104PDPK10.62549825
105MAP2K20.59815587
106CDK60.59378192
107RPS6KA50.59301464
108MAPKAPK50.59122479
109RPS6KC10.58488325
110RPS6KL10.58488325
111PRKCI0.56089840
112CDK20.53358341
113CDK90.53200188
114RPS6KA40.52372820
115CDC70.52141304
116CDK11A0.51315173
117TGFBR20.50840424
118CSF1R0.50495290
119DYRK1B0.50484152
120LYN0.50406408
121PAK10.49726122
122PLK10.49324924
123EIF2AK20.48793477
124RPS6KB20.48274355
125CSNK2A10.47648011
126LRRK20.47545920
127CDK150.47058832
128PRKG20.46937132
129NLK0.46348561
130TSSK60.46027230
131DAPK30.45920475
132CAMK10.45878565
133NEK90.45810001
134ALK0.42985401
135CDK10.41987308
136AURKB0.41894948
137ZAK0.41800726
138DAPK10.41682345
139SYK0.41135561
140CDK180.41030571
141MAP2K40.40829821
142JAK30.40621435
143CDK140.39761931
144RPS6KA60.39364562
145ATR0.39033817
146CAMK2G0.38712144
147ATM0.37214696
148RPS6KA10.36701880
149CSNK2A20.36450628
150RPS6KA20.36369453
151CSNK1G30.35151590

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.03122078
2Parkinsons disease_Homo sapiens_hsa050122.68530352
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.60771191
4Propanoate metabolism_Homo sapiens_hsa006402.58025602
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.57096071
6Ribosome_Homo sapiens_hsa030102.47535069
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.41991966
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.41342840
9Proteasome_Homo sapiens_hsa030502.32417096
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.30701179
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.27153538
12Fatty acid degradation_Homo sapiens_hsa000712.24736576
13Folate biosynthesis_Homo sapiens_hsa007902.07311370
14Carbon metabolism_Homo sapiens_hsa012002.00853035
15DNA replication_Homo sapiens_hsa030302.00680522
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91433169
17Sulfur relay system_Homo sapiens_hsa041221.89967698
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.86074546
19Fanconi anemia pathway_Homo sapiens_hsa034601.83069692
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.77693693
21Pyrimidine metabolism_Homo sapiens_hsa002401.77661746
22Cell cycle_Homo sapiens_hsa041101.76886708
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74019446
24Alzheimers disease_Homo sapiens_hsa050101.72159797
25Peroxisome_Homo sapiens_hsa041461.71703448
26Non-homologous end-joining_Homo sapiens_hsa034501.71697663
27RNA polymerase_Homo sapiens_hsa030201.69262030
28Huntingtons disease_Homo sapiens_hsa050161.64936230
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.63732836
30Biosynthesis of amino acids_Homo sapiens_hsa012301.63634595
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.59706606
32Pyruvate metabolism_Homo sapiens_hsa006201.56871989
33beta-Alanine metabolism_Homo sapiens_hsa004101.56274225
34Pentose phosphate pathway_Homo sapiens_hsa000301.52421241
35Arginine biosynthesis_Homo sapiens_hsa002201.51703801
36Fatty acid metabolism_Homo sapiens_hsa012121.46619493
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.46431306
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45496044
39Nitrogen metabolism_Homo sapiens_hsa009101.38506217
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37718072
41Tryptophan metabolism_Homo sapiens_hsa003801.36508726
42Butanoate metabolism_Homo sapiens_hsa006501.34441518
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33316602
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31950976
45Caffeine metabolism_Homo sapiens_hsa002321.31179820
46Arginine and proline metabolism_Homo sapiens_hsa003301.28103876
47Fatty acid elongation_Homo sapiens_hsa000621.23957220
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.23654460
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23221066
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22507139
51Protein export_Homo sapiens_hsa030601.19618002
52Starch and sucrose metabolism_Homo sapiens_hsa005001.19136737
53Histidine metabolism_Homo sapiens_hsa003401.17944310
54Base excision repair_Homo sapiens_hsa034101.13161031
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13143760
56Cardiac muscle contraction_Homo sapiens_hsa042601.12490608
57mRNA surveillance pathway_Homo sapiens_hsa030151.10233586
58Bladder cancer_Homo sapiens_hsa052191.07690922
59Sulfur metabolism_Homo sapiens_hsa009201.06255308
60Phenylalanine metabolism_Homo sapiens_hsa003601.05702339
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02979574
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02316007
63Purine metabolism_Homo sapiens_hsa002300.99167940
64Metabolic pathways_Homo sapiens_hsa011000.99093951
65Chemical carcinogenesis_Homo sapiens_hsa052040.99057309
66Glutathione metabolism_Homo sapiens_hsa004800.97899791
67Mismatch repair_Homo sapiens_hsa034300.97551910
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97179148
69Selenocompound metabolism_Homo sapiens_hsa004500.97031936
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96029640
71PPAR signaling pathway_Homo sapiens_hsa033200.95875459
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94530398
73Systemic lupus erythematosus_Homo sapiens_hsa053220.93998052
74Complement and coagulation cascades_Homo sapiens_hsa046100.92782376
75Vitamin B6 metabolism_Homo sapiens_hsa007500.90863196
76Galactose metabolism_Homo sapiens_hsa000520.90748435
77Vitamin digestion and absorption_Homo sapiens_hsa049770.85534024
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84515495
79One carbon pool by folate_Homo sapiens_hsa006700.83066866
80Homologous recombination_Homo sapiens_hsa034400.82648537
81Tyrosine metabolism_Homo sapiens_hsa003500.81966386
82Chronic myeloid leukemia_Homo sapiens_hsa052200.80230572
83Fructose and mannose metabolism_Homo sapiens_hsa000510.79165320
84p53 signaling pathway_Homo sapiens_hsa041150.78496190
85Viral carcinogenesis_Homo sapiens_hsa052030.76632492
86Acute myeloid leukemia_Homo sapiens_hsa052210.75900885
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73782971
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73207666
89Non-small cell lung cancer_Homo sapiens_hsa052230.72401983
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.70505152
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67169750
92Alcoholism_Homo sapiens_hsa050340.64909124
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.62623718
94Spliceosome_Homo sapiens_hsa030400.62513308
95Pancreatic cancer_Homo sapiens_hsa052120.61279531
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60278364
97Epstein-Barr virus infection_Homo sapiens_hsa051690.60076383
98Fat digestion and absorption_Homo sapiens_hsa049750.57519275
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.57213690
100Retinol metabolism_Homo sapiens_hsa008300.56240049
101Basal transcription factors_Homo sapiens_hsa030220.54001502
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53536040
103Nucleotide excision repair_Homo sapiens_hsa034200.53301202
104mTOR signaling pathway_Homo sapiens_hsa041500.52607096
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.52455770
106HTLV-I infection_Homo sapiens_hsa051660.50346928
107Lysine degradation_Homo sapiens_hsa003100.49004021
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48532033
109AMPK signaling pathway_Homo sapiens_hsa041520.47809906
110Thyroid cancer_Homo sapiens_hsa052160.47475657
111Staphylococcus aureus infection_Homo sapiens_hsa051500.46640766
112Apoptosis_Homo sapiens_hsa042100.46406094
113Herpes simplex infection_Homo sapiens_hsa051680.44753680
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44632077
115Bile secretion_Homo sapiens_hsa049760.43610840
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41730397
117Shigellosis_Homo sapiens_hsa051310.41565034
118Small cell lung cancer_Homo sapiens_hsa052220.41006928
119Primary immunodeficiency_Homo sapiens_hsa053400.40876892
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39261429
121Other glycan degradation_Homo sapiens_hsa005110.37341506
122Linoleic acid metabolism_Homo sapiens_hsa005910.36962873
123Steroid biosynthesis_Homo sapiens_hsa001000.36615222
124VEGF signaling pathway_Homo sapiens_hsa043700.36522300
125Sphingolipid metabolism_Homo sapiens_hsa006000.36048488
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36023583
127Arachidonic acid metabolism_Homo sapiens_hsa005900.34499257
128Insulin signaling pathway_Homo sapiens_hsa049100.34193198
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30130806
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28338342
131B cell receptor signaling pathway_Homo sapiens_hsa046620.28082373
132Regulation of autophagy_Homo sapiens_hsa041400.27798673
133Legionellosis_Homo sapiens_hsa051340.27119583
134RNA transport_Homo sapiens_hsa030130.26319228
135RNA degradation_Homo sapiens_hsa030180.25310841
136Endometrial cancer_Homo sapiens_hsa052130.23213003
137Hepatitis B_Homo sapiens_hsa051610.21911249
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21715665
139Glycerolipid metabolism_Homo sapiens_hsa005610.20504426
140N-Glycan biosynthesis_Homo sapiens_hsa005100.17844333
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15508037
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14833565
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10196691

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »