PDGFA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfation (GO:0051923)7.54616756
2central nervous system myelination (GO:0022010)5.87123786
3axon ensheathment in central nervous system (GO:0032291)5.87123786
4cellular response to ATP (GO:0071318)5.77289488
5water-soluble vitamin biosynthetic process (GO:0042364)5.66371035
6behavioral response to nicotine (GO:0035095)5.05830229
7regulation of DNA endoreduplication (GO:0032875)4.91770724
8cell proliferation in forebrain (GO:0021846)4.72634129
9positive regulation of cAMP-mediated signaling (GO:0043950)4.37880648
10purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.23087793
113-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.23087793
12gamma-aminobutyric acid transport (GO:0015812)4.17479008
13negative regulation of systemic arterial blood pressure (GO:0003085)4.16196725
14positive regulation of fatty acid beta-oxidation (GO:0032000)4.07591146
15regulation of posttranscriptional gene silencing (GO:0060147)4.07369671
16regulation of gene silencing by miRNA (GO:0060964)4.07369671
17regulation of gene silencing by RNA (GO:0060966)4.07369671
18long-chain fatty acid biosynthetic process (GO:0042759)4.05624066
19indole-containing compound catabolic process (GO:0042436)4.05166949
20indolalkylamine catabolic process (GO:0046218)4.05166949
21tryptophan catabolic process (GO:0006569)4.05166949
22flavonoid metabolic process (GO:0009812)4.01455140
23otic vesicle formation (GO:0030916)3.97379356
24response to UV-C (GO:0010225)3.94747106
25kynurenine metabolic process (GO:0070189)3.92833284
26ensheathment of neurons (GO:0007272)3.91757681
27axon ensheathment (GO:0008366)3.91757681
28dorsal/ventral axis specification (GO:0009950)3.91622755
29myelination (GO:0042552)3.89253034
30pharyngeal system development (GO:0060037)3.87564323
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85292562
32fatty acid elongation (GO:0030497)3.85287809
33positive regulation of fatty acid oxidation (GO:0046321)3.78851121
34cellular anion homeostasis (GO:0030002)3.77952928
35negative regulation of appetite (GO:0032099)3.75746075
36negative regulation of response to food (GO:0032096)3.75746075
37epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.73518109
38DNA deamination (GO:0045006)3.72537977
39musculoskeletal movement (GO:0050881)3.62096428
40multicellular organismal movement (GO:0050879)3.62096428
41positive regulation of actin filament depolymerization (GO:0030836)3.61580480
42negative regulation of transcription regulatory region DNA binding (GO:2000678)3.59569885
43negative regulation of hormone biosynthetic process (GO:0032353)3.56596760
44N-acetylglucosamine metabolic process (GO:0006044)3.47702345
45negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.41742987
46regulation of collateral sprouting (GO:0048670)3.41360624
47positive regulation of cardiac muscle cell differentiation (GO:2000727)3.39146085
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.36806290
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.36458860
50ATP synthesis coupled proton transport (GO:0015986)3.34395033
51energy coupled proton transport, down electrochemical gradient (GO:0015985)3.34395033
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.26626510
53cholesterol biosynthetic process (GO:0006695)3.24973154
54indolalkylamine metabolic process (GO:0006586)3.23829003
55tryptophan metabolic process (GO:0006568)3.20982526
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19893788
57mitochondrial respiratory chain complex I assembly (GO:0032981)3.19893788
58NADH dehydrogenase complex assembly (GO:0010257)3.19893788
59serotonin metabolic process (GO:0042428)3.19338211
60limb bud formation (GO:0060174)3.17538304
61protein complex biogenesis (GO:0070271)3.15276923
62tooth mineralization (GO:0034505)3.13091574
63negative regulation of cardiac muscle tissue development (GO:0055026)3.12580831
64opsonization (GO:0008228)3.10493166
65regulation of sequestering of triglyceride (GO:0010889)3.09016989
66keratan sulfate biosynthetic process (GO:0018146)3.06287168
67negative regulation of neurotransmitter transport (GO:0051589)3.06225184
68estrogen metabolic process (GO:0008210)3.05470746
69calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.05351694
70response to redox state (GO:0051775)3.04973746
71indole-containing compound metabolic process (GO:0042430)3.04947325
72negative regulation of hormone metabolic process (GO:0032351)3.04124199
73peripheral nervous system axon ensheathment (GO:0032292)2.98731617
74myelination in peripheral nervous system (GO:0022011)2.98731617
75regulation of mesoderm development (GO:2000380)2.98647331
76import into cell (GO:0098657)2.97641868
77negative regulation of axon extension involved in axon guidance (GO:0048843)2.97507945
78reflex (GO:0060004)2.96883717
79negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.94021570
80intestinal epithelial cell development (GO:0060576)2.93972896
81apical protein localization (GO:0045176)2.93916746
82regulation of hippo signaling (GO:0035330)2.93916469
83mitochondrial respiratory chain complex assembly (GO:0033108)2.91975288
84parturition (GO:0007567)2.91367483
85sterol biosynthetic process (GO:0016126)2.89152549
86dentate gyrus development (GO:0021542)2.86363137
87membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.85008352
88axonal fasciculation (GO:0007413)2.83965722
89positive regulation of glomerulus development (GO:0090193)2.83578313
90negative regulation of telomere maintenance (GO:0032205)2.83360501
91kidney morphogenesis (GO:0060993)2.82831645
92amine catabolic process (GO:0009310)2.80253232
93cellular biogenic amine catabolic process (GO:0042402)2.80253232
94regulation of cardioblast differentiation (GO:0051890)2.80147638
95neuron cell-cell adhesion (GO:0007158)2.80015371
96neuron recognition (GO:0008038)2.79593805
97negative regulation of gene silencing (GO:0060969)2.79434973
98protein neddylation (GO:0045116)2.77416208
99protein polyglutamylation (GO:0018095)2.77245055
100respiratory electron transport chain (GO:0022904)2.76920289
101cell fate commitment involved in formation of primary germ layer (GO:0060795)2.76639530
102somite development (GO:0061053)2.76431175
103angiogenesis involved in wound healing (GO:0060055)2.76072774
104labyrinthine layer development (GO:0060711)2.75944268
105hemidesmosome assembly (GO:0031581)2.75850354
106negative regulation of protein localization to cell surface (GO:2000009)2.74689297
107primary amino compound metabolic process (GO:1901160)2.74617162
108positive regulation of neurological system process (GO:0031646)2.73852897
109cellular response to exogenous dsRNA (GO:0071360)2.72425295
110positive regulation of potassium ion transmembrane transport (GO:1901381)2.71828721
111negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.71261787
112keratinocyte development (GO:0003334)2.70814982
113regulation of transcription regulatory region DNA binding (GO:2000677)2.70150934
114regulation of germinal center formation (GO:0002634)2.69907150
115spinal cord motor neuron differentiation (GO:0021522)2.69871776
116myelin maintenance (GO:0043217)2.69133037
117electron transport chain (GO:0022900)2.68743698
118enteric nervous system development (GO:0048484)2.68665631
119negative regulation of neurotransmitter secretion (GO:0046929)2.68660131
120vitamin biosynthetic process (GO:0009110)2.67939490
121magnesium ion transport (GO:0015693)2.67094028
122negative regulation of mast cell activation (GO:0033004)2.66506505
123eye photoreceptor cell differentiation (GO:0001754)2.66340384
124photoreceptor cell differentiation (GO:0046530)2.66340384
125embryonic hindlimb morphogenesis (GO:0035116)2.66061334
126plasma membrane repair (GO:0001778)2.65910463
127pituitary gland development (GO:0021983)2.65095783
128signal transduction involved in regulation of gene expression (GO:0023019)2.64852108
129cobalamin metabolic process (GO:0009235)2.63358721
130regulation of response to food (GO:0032095)2.61885026
131cellular response to epinephrine stimulus (GO:0071872)2.61097653
132substantia nigra development (GO:0021762)2.60187880
133negative regulation by host of viral transcription (GO:0043922)2.59592790
134lateral sprouting from an epithelium (GO:0060601)2.57693071
135negative regulation of axon extension (GO:0030517)2.57594117
136oligodendrocyte differentiation (GO:0048709)2.57531556
137multicellular organismal signaling (GO:0035637)2.57468324
138GPI anchor metabolic process (GO:0006505)2.56783738
139organ induction (GO:0001759)2.56707262
140glucosamine-containing compound metabolic process (GO:1901071)2.56682535
141neuron remodeling (GO:0016322)2.56492509
142isoprenoid biosynthetic process (GO:0008299)2.55601440
143negative regulation of axon guidance (GO:1902668)2.55284009
144negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.54716395
145positive regulation of pseudopodium assembly (GO:0031274)2.53277798
146L-amino acid import (GO:0043092)2.51089343
147transmission of nerve impulse (GO:0019226)2.50545346
148regulation of pseudopodium assembly (GO:0031272)2.44705524
149asymmetric protein localization (GO:0008105)2.44168042
150negative regulation of keratinocyte proliferation (GO:0010839)2.44035538
151peripheral nervous system development (GO:0007422)2.42853410
152neuronal action potential propagation (GO:0019227)2.42601959
153establishment of mitochondrion localization (GO:0051654)2.40792940
154GTP biosynthetic process (GO:0006183)2.40659761
155lung-associated mesenchyme development (GO:0060484)2.39678447
156positive regulation of protein depolymerization (GO:1901881)2.39002824
157ephrin receptor signaling pathway (GO:0048013)2.37645089
158dopamine biosynthetic process (GO:0042416)2.33814284
159dendritic spine morphogenesis (GO:0060997)2.32279341
160negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.31257324
161response to hepatocyte growth factor (GO:0035728)2.28246109
162cellular response to hepatocyte growth factor stimulus (GO:0035729)2.28246109
163polarized epithelial cell differentiation (GO:0030859)2.27750384
164detection of temperature stimulus involved in sensory perception (GO:0050961)2.27127652
165detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.27127652
166astrocyte development (GO:0014002)2.25606863
167response to epinephrine (GO:0071871)2.25180807
168virion attachment to host cell (GO:0019062)2.25118253
169adhesion of symbiont to host cell (GO:0044650)2.25118253
170presynaptic membrane organization (GO:0097090)2.23161083
171positive regulation of synapse assembly (GO:0051965)2.23112420
172amino acid import (GO:0043090)2.22277864
173presynaptic membrane assembly (GO:0097105)2.20245398
174positive regulation of gastrulation (GO:2000543)2.20205779
175short-term memory (GO:0007614)2.17696595
176neuronal ion channel clustering (GO:0045161)2.16263319
177desmosome organization (GO:0002934)2.15445926
178branching involved in salivary gland morphogenesis (GO:0060445)2.15064401
179negative regulation of axonogenesis (GO:0050771)2.14703247
180tight junction assembly (GO:0070830)2.13211906
181positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.08904584
182response to methylmercury (GO:0051597)2.07745948
183notochord development (GO:0030903)2.07673258
184anterior/posterior axis specification, embryo (GO:0008595)2.04822342
185regulation of glomerular filtration (GO:0003093)2.04532122
186semaphorin-plexin signaling pathway (GO:0071526)2.03287580
187regulation of axon extension involved in axon guidance (GO:0048841)2.03213545
188UTP biosynthetic process (GO:0006228)2.01824490
189establishment or maintenance of bipolar cell polarity (GO:0061245)2.01355489
190establishment or maintenance of apical/basal cell polarity (GO:0035088)2.01355489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.38779635
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.09283809
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.92235192
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.92235192
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.92235192
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.87976993
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.87638930
8EZH2_22144423_ChIP-Seq_EOC_Human2.51724179
9EWS_26573619_Chip-Seq_HEK293_Human2.39564681
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18430976
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16784046
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04842382
13ZNF274_21170338_ChIP-Seq_K562_Hela1.94031927
14EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92443597
15RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92443597
16EZH2_27304074_Chip-Seq_ESCs_Mouse1.92090917
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.89200382
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86944418
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83703445
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82532155
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82273923
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81867283
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79123248
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78220711
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77103780
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76707447
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74571886
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.73785104
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71319952
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.65575291
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65498549
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64206626
33GBX2_23144817_ChIP-Seq_PC3_Human1.63517630
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62635163
35* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62161245
36* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.61484615
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58897310
38IGF1R_20145208_ChIP-Seq_DFB_Human1.58428764
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58426286
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58034760
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.57498808
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57483215
43* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56499675
44BCAT_22108803_ChIP-Seq_LS180_Human1.56215530
45* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54049914
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.53344662
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53220576
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52026803
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.50551824
50* RNF2_27304074_Chip-Seq_ESCs_Mouse1.49873481
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.48039882
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45712788
53STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.44504872
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44444756
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.44391203
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43994139
57MYC_18940864_ChIP-ChIP_HL60_Human1.42676755
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.41187058
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40858777
60CBP_20019798_ChIP-Seq_JUKART_Human1.39466891
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39466891
62AR_21572438_ChIP-Seq_LNCaP_Human1.38334790
63SMAD4_21799915_ChIP-Seq_A2780_Human1.37921820
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.36787892
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35947826
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33762620
67TDRD3_21172665_ChIP-Seq_MCF-7_Human1.32872421
68* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.30755229
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.30403287
70TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.29006297
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.27397353
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.25922538
73VDR_22108803_ChIP-Seq_LS180_Human1.25839209
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.24523354
75FUS_26573619_Chip-Seq_HEK293_Human1.24248039
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24204592
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.24169021
78* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23795124
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.23697323
80* TP53_20018659_ChIP-ChIP_R1E_Mouse1.23505874
81IRF1_19129219_ChIP-ChIP_H3396_Human1.23265355
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21542640
83AR_25329375_ChIP-Seq_VCAP_Human1.21430466
84* RING1B_27294783_Chip-Seq_NPCs_Mouse1.20969468
85SOX2_19829295_ChIP-Seq_ESCs_Human1.20453224
86NANOG_19829295_ChIP-Seq_ESCs_Human1.20453224
87NANOG_16153702_ChIP-ChIP_HESCs_Human1.20423011
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19903600
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19871913
90* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19002611
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18428845
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18293656
93TCF4_23295773_ChIP-Seq_U87_Human1.18022222
94* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17827717
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17565158
96* STAT3_23295773_ChIP-Seq_U87_Human1.17551102
97ELK1_19687146_ChIP-ChIP_HELA_Human1.17210890
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.15422260
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15170403
100FOXA1_25329375_ChIP-Seq_VCAP_Human1.14363221
101FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14363221
102P53_22387025_ChIP-Seq_ESCs_Mouse1.14319579
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.14167673
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13464250
105* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13419987
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.12785534
107* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12333088
108* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11584006
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11175091
110EP300_21415370_ChIP-Seq_HL-1_Mouse1.11064454
111* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09936040
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08191065
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.08138467
114SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07824098
115* SOX2_20726797_ChIP-Seq_SW620_Human1.07740706
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07352070
117RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07010441
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06474603
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06474603
120EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05478908
121STAT3_18555785_Chip-Seq_ESCs_Mouse1.04875610
122AHR_22903824_ChIP-Seq_MCF-7_Human1.04753516
123ARNT_22903824_ChIP-Seq_MCF-7_Human1.04708715
124CDX2_22108803_ChIP-Seq_LS180_Human1.04493301
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04279763
126LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04093274
127ESR1_21235772_ChIP-Seq_MCF-7_Human1.03995810
128CDX2_20551321_ChIP-Seq_CACO-2_Human1.03975225
129POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03573994
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.03462341
131* TCF4_22108803_ChIP-Seq_LS180_Human1.03141312
132JUN_21703547_ChIP-Seq_K562_Human1.01337022
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00682882
134* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99638838
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99528063
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98969259
137DROSHA_22980978_ChIP-Seq_HELA_Human0.98738163
138SMAD3_21741376_ChIP-Seq_EPCs_Human0.97280535
139* RING1B_27294783_Chip-Seq_ESCs_Mouse0.95048283
140TP53_18474530_ChIP-ChIP_U2OS_Human0.94819183
141TP53_16413492_ChIP-PET_HCT116_Human0.94536246
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94312589
143* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93923850
144ER_23166858_ChIP-Seq_MCF-7_Human0.93306528
145* KLF5_25053715_ChIP-Seq_YYC3_Human0.92818754
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92070609
147ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91869027
148SMAD3_21741376_ChIP-Seq_HESCs_Human0.91411178
149CJUN_26792858_Chip-Seq_BT549_Human0.91298011
150TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90745728
151RNF2_27304074_Chip-Seq_NSC_Mouse0.89778833
152* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.89114262
153PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88004421
154* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87109589
155TAF15_26573619_Chip-Seq_HEK293_Human0.85314435
156* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.85288244
157* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84536703
158EOMES_21245162_ChIP-Seq_HESCs_Human0.84244726
159* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83133575
160TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82164564
161WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82119989
162P300_19829295_ChIP-Seq_ESCs_Human0.82013877
163ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81990312
164REST_21632747_ChIP-Seq_MESCs_Mouse0.81396468
165NR3C1_23031785_ChIP-Seq_PC12_Mouse0.79465198

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.32481822
2MP0005646_abnormal_pituitary_gland3.19459525
3MP0006292_abnormal_olfactory_placode2.74481617
4MP0002138_abnormal_hepatobiliary_system2.71798093
5MP0003646_muscle_fatigue2.71209186
6MP0002160_abnormal_reproductive_system2.69663942
7MP0002837_dystrophic_cardiac_calcinosis2.65685439
8MP0008872_abnormal_physiological_respon2.49468619
9MP0000462_abnormal_digestive_system2.45807439
10MP0003136_yellow_coat_color2.40869540
11MP0000762_abnormal_tongue_morphology2.36666883
12MP0009780_abnormal_chondrocyte_physiolo2.35125358
13MP0000631_abnormal_neuroendocrine_gland2.34395558
14MP0005623_abnormal_meninges_morphology2.28377959
15MP0003880_abnormal_central_pattern2.26310726
16MP0003950_abnormal_plasma_membrane2.14939788
17MP0008877_abnormal_DNA_methylation2.13686147
18MP0005389_reproductive_system_phenotype2.08656270
19MP0002876_abnormal_thyroid_physiology1.98895141
20MP0004272_abnormal_basement_membrane1.91397301
21MP0000920_abnormal_myelination1.90083435
22MP0003011_delayed_dark_adaptation1.89922803
23MP0005171_absent_coat_pigmentation1.81155203
24MP0005551_abnormal_eye_electrophysiolog1.79573281
25MP0000778_abnormal_nervous_system1.77415154
26MP0004270_analgesia1.76432894
27MP0004145_abnormal_muscle_electrophysio1.72011698
28MP0002139_abnormal_hepatobiliary_system1.71965963
29MP0003638_abnormal_response/metabolism_1.70512399
30MP0004742_abnormal_vestibular_system1.66955349
31MP0001485_abnormal_pinna_reflex1.65762079
32MP0003937_abnormal_limbs/digits/tail_de1.64737930
33MP0009379_abnormal_foot_pigmentation1.62682480
34MP0002277_abnormal_respiratory_mucosa1.62031327
35MP0005084_abnormal_gallbladder_morpholo1.61569763
36MP0004215_abnormal_myocardial_fiber1.58289134
37MP0000678_abnormal_parathyroid_gland1.56615454
38MP0010030_abnormal_orbit_morphology1.55951081
39MP0002163_abnormal_gland_morphology1.55315233
40MP0004133_heterotaxia1.53575942
41MP0001440_abnormal_grooming_behavior1.51472526
42MP0003941_abnormal_skin_development1.51169761
43MP0002089_abnormal_postnatal_growth/wei1.51101601
44MP0000049_abnormal_middle_ear1.50875895
45MP0002102_abnormal_ear_morphology1.50797653
46* MP0009250_abnormal_appendicular_skeleto1.49101036
47MP0001905_abnormal_dopamine_level1.48899757
48MP0005379_endocrine/exocrine_gland_phen1.47791197
49MP0001529_abnormal_vocalization1.45732224
50MP0004885_abnormal_endolymph1.42717102
51MP0000537_abnormal_urethra_morphology1.42591272
52MP0003315_abnormal_perineum_morphology1.42111470
53MP0003755_abnormal_palate_morphology1.41158412
54MP0002938_white_spotting1.39370518
55MP0010678_abnormal_skin_adnexa1.38567020
56MP0003385_abnormal_body_wall1.38495368
57MP0003283_abnormal_digestive_organ1.38033394
58MP0002272_abnormal_nervous_system1.36411998
59MP0003938_abnormal_ear_development1.34732147
60MP0005257_abnormal_intraocular_pressure1.34292153
61MP0004130_abnormal_muscle_cell1.34150789
62MP0002638_abnormal_pupillary_reflex1.32153640
63MP0008438_abnormal_cutaneous_collagen1.28390253
64MP0003329_amyloid_beta_deposits1.27449701
65MP0003879_abnormal_hair_cell1.27020579
66MP0002734_abnormal_mechanical_nocicepti1.24766128
67MP0005409_darkened_coat_color1.24653552
68MP0002233_abnormal_nose_morphology1.24295999
69MP0002064_seizures1.22481243
70MP0000751_myopathy1.22213023
71MP0001299_abnormal_eye_distance/1.21842999
72MP0002736_abnormal_nociception_after1.21838196
73MP0002751_abnormal_autonomic_nervous1.20093163
74MP0003634_abnormal_glial_cell1.17218628
75MP0000383_abnormal_hair_follicle1.17080552
76MP0002254_reproductive_system_inflammat1.15411593
77MP0004019_abnormal_vitamin_homeostasis1.15252031
78MP0004142_abnormal_muscle_tone1.12509685
79MP0001188_hyperpigmentation1.12342004
80MP0005253_abnormal_eye_physiology1.12030032
81MP0003718_maternal_effect1.11944959
82MP0000230_abnormal_systemic_arterial1.11887527
83MP0003119_abnormal_digestive_system1.11044211
84MP0001486_abnormal_startle_reflex1.10472904
85MP0003635_abnormal_synaptic_transmissio1.09158981
86MP0004858_abnormal_nervous_system1.08477501
87MP0009745_abnormal_behavioral_response1.07311604
88MP0001919_abnormal_reproductive_system1.06787097
89MP0001348_abnormal_lacrimal_gland1.06683898
90MP0001542_abnormal_bone_strength1.06215898
91MP0001853_heart_inflammation1.06210672
92MP0001970_abnormal_pain_threshold1.05785039
93MP0001765_abnormal_ion_homeostasis1.03291754
94MP0005503_abnormal_tendon_morphology1.02863494
95MP0002733_abnormal_thermal_nociception1.01899673
96MP0008789_abnormal_olfactory_epithelium1.01805668
97MP0009046_muscle_twitch1.01616528
98MP0000467_abnormal_esophagus_morphology1.00207774
99MP0001340_abnormal_eyelid_morphology0.99453193
100MP0001963_abnormal_hearing_physiology0.98962595
101MP0003690_abnormal_glial_cell0.98757695
102MP0003137_abnormal_impulse_conducting0.98655926
103MP0003806_abnormal_nucleotide_metabolis0.98449102
104MP0004859_abnormal_synaptic_plasticity0.96844531
105MP0005410_abnormal_fertilization0.96273510
106MP0002796_impaired_skin_barrier0.96232386
107MP0005332_abnormal_amino_acid0.95651048
108MP0005499_abnormal_olfactory_system0.95338059
109MP0005394_taste/olfaction_phenotype0.95338059
110MP0002249_abnormal_larynx_morphology0.95249960
111MP0002184_abnormal_innervation0.93915127
112MP0002752_abnormal_somatic_nervous0.93665409
113MP0000647_abnormal_sebaceous_gland0.93653169
114MP0002882_abnormal_neuron_morphology0.92727127
115MP0003878_abnormal_ear_physiology0.92628164
116MP0005377_hearing/vestibular/ear_phenot0.92628164
117MP0010386_abnormal_urinary_bladder0.91979397
118MP0002735_abnormal_chemical_nociception0.91503687
119MP0002572_abnormal_emotion/affect_behav0.91381377
120MP0000026_abnormal_inner_ear0.90816410
121MP0002063_abnormal_learning/memory/cond0.90671021
122* MP0001177_atelectasis0.89489024
123* MP0002295_abnormal_pulmonary_circulatio0.89006625
124MP0000955_abnormal_spinal_cord0.88766987
125MP0001849_ear_inflammation0.88598483
126MP0001968_abnormal_touch/_nociception0.88535241
127MP0000534_abnormal_ureter_morphology0.88363850
128MP0000749_muscle_degeneration0.88194016
129MP0008004_abnormal_stomach_pH0.87960514
130MP0005508_abnormal_skeleton_morphology0.87710165
131MP0000613_abnormal_salivary_gland0.86868464
132MP0004484_altered_response_of0.86307598
133MP0005275_abnormal_skin_tensile0.85509850
134MP0005448_abnormal_energy_balance0.85024064
135MP0010234_abnormal_vibrissa_follicle0.85004233
136MP0003724_increased_susceptibility_to0.84927019
137MP0002234_abnormal_pharynx_morphology0.84391988
138MP0000579_abnormal_nail_morphology0.84169388
139MP0004185_abnormal_adipocyte_glucose0.83873370
140MP0006072_abnormal_retinal_apoptosis0.83545271
141MP0005386_behavior/neurological_phenoty0.83188437
142MP0004924_abnormal_behavior0.83188437
143MP0009053_abnormal_anal_canal0.82515921
144MP0002108_abnormal_muscle_morphology0.82497693
145MP0008875_abnormal_xenobiotic_pharmacok0.82348523
146MP0000372_irregular_coat_pigmentation0.81977272
147MP0009765_abnormal_xenobiotic_induced0.80206471
148MP0002653_abnormal_ependyma_morphology0.79841068
149MP0002928_abnormal_bile_duct0.79009003
150MP0005195_abnormal_posterior_eye0.78775459
151MP0002282_abnormal_trachea_morphology0.77783050
152MP0005174_abnormal_tail_pigmentation0.75678277
153MP0005620_abnormal_muscle_contractility0.75517240
154MP0005636_abnormal_mineral_homeostasis0.75409058
155MP0004085_abnormal_heartbeat0.75021472
156MP0003567_abnormal_fetal_cardiomyocyte0.71848716
157MP0005670_abnormal_white_adipose0.69810897
158MP0008775_abnormal_heart_ventricle0.69360811
159MP0003936_abnormal_reproductive_system0.68669299
160MP0001986_abnormal_taste_sensitivity0.68490112
161MP0001501_abnormal_sleep_pattern0.67047765
162MP0000163_abnormal_cartilage_morphology0.64701343
163MP0005595_abnormal_vascular_smooth0.63979881
164MP0003942_abnormal_urinary_system0.63507603

Predicted human phenotypes

RankGene SetZ-score
1Pendular nystagmus (HP:0012043)4.66805352
2Methylmalonic acidemia (HP:0002912)4.24609132
3Genetic anticipation (HP:0003743)4.14117883
4Abolished electroretinogram (ERG) (HP:0000550)4.04785847
5Conjunctival hamartoma (HP:0100780)3.90593670
6Pancreatic cysts (HP:0001737)3.76203836
7Pancreatic fibrosis (HP:0100732)3.58644739
8Methylmalonic aciduria (HP:0012120)3.54498127
9Confusion (HP:0001289)3.45155888
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.44230482
11Congenital, generalized hypertrichosis (HP:0004540)3.33640778
12Progressive cerebellar ataxia (HP:0002073)3.32890933
13True hermaphroditism (HP:0010459)3.32308575
14Agitation (HP:0000713)3.31335824
15Severe visual impairment (HP:0001141)3.22513358
16Decreased central vision (HP:0007663)3.17091350
17Ileus (HP:0002595)3.14510847
18Increased corneal curvature (HP:0100692)3.10071063
19Keratoconus (HP:0000563)3.10071063
203-Methylglutaconic aciduria (HP:0003535)3.07468426
21Furrowed tongue (HP:0000221)3.06481332
22Hamartoma of the eye (HP:0010568)3.05305456
23Porencephaly (HP:0002132)2.95073879
24Abnormality of homocysteine metabolism (HP:0010919)2.94894437
25Homocystinuria (HP:0002156)2.94894437
26Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.93068034
27Degeneration of the lateral corticospinal tracts (HP:0002314)2.93068034
28Asplenia (HP:0001746)2.87211221
29Abnormality of the proximal phalanges of the hand (HP:0009834)2.87201115
30Congenital malformation of the right heart (HP:0011723)2.86812569
31Double outlet right ventricle (HP:0001719)2.86812569
32Cerebral hypomyelination (HP:0006808)2.86207823
33Abnormal rod and cone electroretinograms (HP:0008323)2.83205928
34Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.78153836
35Premature rupture of membranes (HP:0001788)2.73352356
36Aplasia/Hypoplasia of the spleen (HP:0010451)2.70500444
37Neurofibrillary tangles (HP:0002185)2.69770497
38Bone cyst (HP:0012062)2.68979782
39Atrophic scars (HP:0001075)2.68408568
40Stenosis of the external auditory canal (HP:0000402)2.63462282
41Concave nail (HP:0001598)2.57862805
42Peripheral hypomyelination (HP:0007182)2.56640879
43Hypoplasia of the uterus (HP:0000013)2.54505979
44Abnormality of vitamin B metabolism (HP:0004340)2.52918626
45Abnormality of the phalanges of the 5th finger (HP:0004213)2.50654754
46Hemiplegia (HP:0002301)2.46310973
47Gaze-evoked nystagmus (HP:0000640)2.45013604
48Nephronophthisis (HP:0000090)2.44875918
49Meningioma (HP:0002858)2.43936336
50Abnormality of the vitamin B12 metabolism (HP:0004341)2.42183338
51Goiter (HP:0000853)2.41769567
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.41405070
53Nasolacrimal duct obstruction (HP:0000579)2.38287390
54Hemiparesis (HP:0001269)2.37225451
55Esophageal atresia (HP:0002032)2.35838166
56Abnormality of methionine metabolism (HP:0010901)2.32083467
57Parakeratosis (HP:0001036)2.31787649
58Alacrima (HP:0000522)2.31385785
59Cerebral inclusion bodies (HP:0100314)2.30580525
60Congenital stationary night blindness (HP:0007642)2.29503534
61Fragile nails (HP:0001808)2.29382595
62Aplasia/hypoplasia of the uterus (HP:0008684)2.28564342
63Cystic liver disease (HP:0006706)2.25098946
64Chorioretinal atrophy (HP:0000533)2.24372954
65Mixed hearing impairment (HP:0000410)2.23853603
66Muscle fiber splitting (HP:0003555)2.22472365
67Split foot (HP:0001839)2.22125081
68Aplasia involving bones of the extremities (HP:0009825)2.22005789
69Aplasia involving bones of the upper limbs (HP:0009823)2.22005789
70Aplasia of the phalanges of the hand (HP:0009802)2.22005789
71Visual hallucinations (HP:0002367)2.21804067
72Ulnar claw (HP:0001178)2.20897427
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.20019354
74Abnormality of the nasal septum (HP:0000419)2.19928381
75Short 1st metacarpal (HP:0010034)2.19522478
76Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.19522478
77Delayed epiphyseal ossification (HP:0002663)2.18112591
78Molar tooth sign on MRI (HP:0002419)2.16469226
79Abnormality of midbrain morphology (HP:0002418)2.16469226
80Small hand (HP:0200055)2.16310211
81Abnormality of the middle phalanges of the toes (HP:0010183)2.15648190
82Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13753723
83Abnormality of secondary sexual hair (HP:0009888)2.13690831
84Abnormality of the axillary hair (HP:0100134)2.13690831
85Chin dimple (HP:0010751)2.13425186
86Sensory axonal neuropathy (HP:0003390)2.13219836
87Diplopia (HP:0000651)2.12024121
88Abnormality of binocular vision (HP:0011514)2.12024121
89Abnormality of the corticospinal tract (HP:0002492)2.11292211
90Optic nerve hypoplasia (HP:0000609)2.11192809
91Short femoral neck (HP:0100864)2.07485263
92Muscle hypertrophy of the lower extremities (HP:0008968)2.05931912
93Attenuation of retinal blood vessels (HP:0007843)2.05902357
94Abnormality of the lacrimal duct (HP:0011481)2.05269975
95Male pseudohermaphroditism (HP:0000037)2.04940376
96Pterygium (HP:0001059)2.03374359
97Morphological abnormality of the middle ear (HP:0008609)2.03065479
98Acute necrotizing encephalopathy (HP:0006965)2.02426060
99Oral leukoplakia (HP:0002745)2.02200495
100Abnormality of the 1st metacarpal (HP:0010009)2.01536233
101Onion bulb formation (HP:0003383)2.01058696
102Abnormality of the renal medulla (HP:0100957)1.99559946
103Aplasia/Hypoplasia of the tibia (HP:0005772)1.99119423
104Short tibia (HP:0005736)1.98842781
105Epiphyseal dysplasia (HP:0002656)1.98355747
106Sclerocornea (HP:0000647)1.96768576
107Coronal craniosynostosis (HP:0004440)1.96345861
108Tinnitus (HP:0000360)1.96242367
109Humeroradial synostosis (HP:0003041)1.95932369
110Synostosis involving the elbow (HP:0003938)1.95932369
111Retinal dysplasia (HP:0007973)1.95293651
112Abnormality of the renal cortex (HP:0011035)1.94667670
113Abnormality of the renal collecting system (HP:0004742)1.94600707
114Congenital ichthyosiform erythroderma (HP:0007431)1.94461298
115Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.92751792
116Adrenal hypoplasia (HP:0000835)1.92294500
117Impaired smooth pursuit (HP:0007772)1.91338048
118Morphological abnormality of the inner ear (HP:0011390)1.91067317
119Fragile skin (HP:0001030)1.90886685
120Down-sloping shoulders (HP:0200021)1.89901190
121Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.88743833
122Abnormality of chromosome stability (HP:0003220)1.87210148
123Abnormal mitochondria in muscle tissue (HP:0008316)1.86544310
124Absent thumb (HP:0009777)1.85597187
125Abnormality of ocular smooth pursuit (HP:0000617)1.85494985
126Abnormality of vitamin metabolism (HP:0100508)1.84920672
127Foot dorsiflexor weakness (HP:0009027)1.83966414
128Restlessness (HP:0000711)1.83054696
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.82466392
130Long nose (HP:0003189)1.81534078
131Abnormality of the nasolacrimal system (HP:0000614)1.81160449
132Acute encephalopathy (HP:0006846)1.79756267
133Abnormality of the phalanges of the 2nd finger (HP:0009541)1.79518082
134Abnormal umbilical cord blood vessels (HP:0011403)1.78777753
135Single umbilical artery (HP:0001195)1.78777753
136Abnormality of the fetal cardiovascular system (HP:0010948)1.78777753
137Right ventricular cardiomyopathy (HP:0011663)1.77191092
138Abnormality of cochlea (HP:0000375)1.77065838
139Aplasia of the musculature (HP:0100854)1.76530313
140Gonadotropin excess (HP:0000837)1.76445180
141Abnormal ventriculo-arterial connection (HP:0011563)1.76066843
142Transposition of the great arteries (HP:0001669)1.76066843
143Abnormal connection of the cardiac segments (HP:0011545)1.76066843
144Preauricular pit (HP:0004467)1.75585151
145Periauricular skin pits (HP:0100277)1.75585151
146Segmental peripheral demyelination/remyelination (HP:0003481)1.74696000
147Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.74119639
148Irregular epiphyses (HP:0010582)1.74078405
149Upper limb muscle weakness (HP:0003484)1.74022999
150Bronchomalacia (HP:0002780)1.73904003
151Increased CSF lactate (HP:0002490)1.73230898
152Termporal pattern (HP:0011008)1.73180034
153Insidious onset (HP:0003587)1.73180034
154Short hallux (HP:0010109)1.72449305
155Abnormality of DNA repair (HP:0003254)1.72330958
156Abnormality of the umbilical cord (HP:0010881)1.71960844
157Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.71611421
158Small epiphyses (HP:0010585)1.70335061
159Scapular winging (HP:0003691)1.69683811
160Milia (HP:0001056)1.67331643
161Symphalangism affecting the phalanges of the hand (HP:0009773)1.65332528
162Abnormality of the foot musculature (HP:0001436)1.64617791
163Hypoplastic pelvis (HP:0008839)1.63812067
164Abnormality of dentin (HP:0010299)1.63212069
165Fused cervical vertebrae (HP:0002949)1.62649724
166Anomalous pulmonary venous return (HP:0010772)1.61901023
167Abnormality of the calf musculature (HP:0001430)1.60923652
168Abnormal hemoglobin (HP:0011902)1.60870720
169Leukodystrophy (HP:0002415)1.58489001
170Stridor (HP:0010307)1.57758570
171Abnormality of the pulmonary veins (HP:0011718)1.57006608
172Progressive macrocephaly (HP:0004481)1.56812743
173Aplasia/Hypoplasia of the hallux (HP:0008362)1.56400232
174Congenital sensorineural hearing impairment (HP:0008527)1.55395700
175Cupped ear (HP:0000378)1.55255606
176Decreased lacrimation (HP:0000633)1.54292584
177Hypoplasia of the ulna (HP:0003022)1.54048614
178Steppage gait (HP:0003376)1.52420216
179Partial duplication of thumb phalanx (HP:0009944)1.52329727
180Abnormality of the parathyroid morphology (HP:0011766)1.50472053
181Aplasia/Hypoplasia involving the musculature (HP:0001460)1.50332064
182Hypoplastic ischia (HP:0003175)1.50000040
183Difficulty climbing stairs (HP:0003551)1.49608513
184Mitochondrial inheritance (HP:0001427)1.48755462
185Achilles tendon contracture (HP:0001771)1.48723721
186Abnormality of the shoulder girdle musculature (HP:0001435)1.48398563
187Aplasia/Hypoplasia of the ulna (HP:0006495)1.48345751
188Septo-optic dysplasia (HP:0100842)1.48098728
189Abnormally folded helix (HP:0008544)1.47995957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.49659539
2GRK14.03255090
3STK394.01753477
4ADRBK23.49182957
5EPHA23.35868863
6CASK2.98663264
7VRK22.72163358
8EPHB12.61213379
9PNCK2.53602899
10NME12.52240279
11PRKD22.45457804
12NUAK12.44422374
13TAF12.44129733
14PINK12.39301376
15BCR2.36747605
16MAP4K22.28619133
17OXSR12.10991591
18MUSK2.02253912
19PKN11.94884702
20MET1.89342061
21ACVR1B1.88786219
22DDR21.82646681
23MAP2K21.73878861
24MST41.72382874
25WNK41.62817357
26INSRR1.61886840
27TYRO31.58011181
28MAPKAPK51.57596225
29MAPK151.57575550
30LIMK11.57377141
31WNK31.56905549
32VRK11.55299495
33STK161.51037902
34LATS21.49358473
35TAOK31.49228714
36AKT31.48388683
37NTRK11.46834224
38PBK1.46519823
39CAMK2D1.44817978
40ROCK21.40846070
41FGR1.39429734
42CDC71.35791052
43CAMK2B1.34633671
44PAK31.32968951
45DAPK21.32705528
46PIK3CA1.29803310
47LMTK21.29011578
48UHMK11.27983733
49IRAK21.27599856
50ARAF1.22427534
51FER1.22183140
52PLK21.21956588
53IRAK11.21591653
54CSNK1G11.21467023
55TIE11.17903735
56MAPKAPK31.15113321
57GRK51.11360280
58DYRK21.10567257
59STK38L1.09265173
60DMPK1.09249990
61PRPF4B1.08986746
62MAP3K21.06662344
63EPHA41.03880825
64CSNK1G21.03626341
65CAMK2A1.03464846
66PTK20.99788269
67BLK0.99338948
68STK240.97981663
69CAMK2G0.97633757
70MST1R0.97267202
71IKBKB0.97126587
72KSR20.96886034
73MARK10.96735616
74MAP3K120.93538512
75EPHB20.93454208
76PRKCG0.91652548
77PRKCE0.90686006
78MKNK20.89720062
79TLK10.87857936
80MAP3K110.87823741
81TNIK0.87381088
82PRKCI0.84427502
83PLK30.81881736
84ROCK10.81495737
85WNK10.80685415
86MAP3K30.80580805
87MAPK130.77847430
88TXK0.77839385
89ADRBK10.77722594
90MAP3K90.77606531
91MAP2K10.76974712
92MINK10.75952558
93BMPR20.73602037
94TEC0.72946008
95ZAK0.72502887
96PHKG20.71277345
97PHKG10.71277345
98TRIM280.71096981
99STK30.70348375
100CDK140.69266876
101MOS0.69130277
102BRSK20.69125439
103ERBB20.68805117
104ABL20.67748465
105BUB10.67724460
106MAP3K40.67392009
107PAK60.66837384
108FGFR20.66710783
109GSK3A0.66131424
110NTRK30.65958876
111PRKG20.65846275
112DAPK10.64754180
113NEK60.63701740
114NLK0.61828591
115CDC42BPA0.61761577
116SGK2230.60330856
117SGK4940.60330856
118GRK70.59241959
119BRAF0.59084299
120PRKD10.58889090
121PAK10.58746342
122TESK10.58389197
123CSNK1E0.56840526
124FLT30.55379493
125IGF1R0.53801366
126EIF2AK30.53491451
127PAK20.50828933
128SGK20.50625732
129CDK50.49966217
130DAPK30.49930915
131AURKA0.49351994
132CSNK1G30.49351744
133PTK2B0.49033362
134PRKCA0.47915597
135GRK60.47521501
136MARK20.46587569
137CSNK1A1L0.45707696
138BMPR1B0.44220048
139OBSCN0.44218930
140PDK20.43429429
141CDK150.43110482
142MYLK0.42644475
143CSNK1A10.41447930
144CDK180.40362253
145PLK10.38983411
146CSNK2A10.38354052
147CDK11A0.37988173
148ERBB40.37924507
149PRKACA0.37430536
150RPS6KA50.36121645
151EIF2AK20.34021537
152MAP2K60.34008765
153ABL10.33667269
154MELK0.32073370
155CHUK0.31626532
156PRKG10.31333568
157BCKDK0.30480315
158NEK10.29103625
159PRKCQ0.27944330
160CDK90.27035512

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.99198100
2Oxidative phosphorylation_Homo sapiens_hsa001903.60337620
3Steroid biosynthesis_Homo sapiens_hsa001003.04881534
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.03122744
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.88004455
6Parkinsons disease_Homo sapiens_hsa050122.68129872
7Homologous recombination_Homo sapiens_hsa034402.57823613
8Alzheimers disease_Homo sapiens_hsa050102.32495910
9Phototransduction_Homo sapiens_hsa047442.13695653
10Collecting duct acid secretion_Homo sapiens_hsa049662.11883887
11Vitamin digestion and absorption_Homo sapiens_hsa049772.10661517
12Huntingtons disease_Homo sapiens_hsa050162.08278166
13Axon guidance_Homo sapiens_hsa043602.05585511
14Tight junction_Homo sapiens_hsa045302.03258758
15Ether lipid metabolism_Homo sapiens_hsa005651.99511721
16Vibrio cholerae infection_Homo sapiens_hsa051101.98263466
17Fatty acid elongation_Homo sapiens_hsa000621.96605936
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95053887
19Chemical carcinogenesis_Homo sapiens_hsa052041.86564605
20Cardiac muscle contraction_Homo sapiens_hsa042601.82534470
21Hedgehog signaling pathway_Homo sapiens_hsa043401.73588232
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73193914
23Tryptophan metabolism_Homo sapiens_hsa003801.68124210
24Basal transcription factors_Homo sapiens_hsa030221.62400678
25Nitrogen metabolism_Homo sapiens_hsa009101.60437787
26Hippo signaling pathway_Homo sapiens_hsa043901.59800338
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57924393
28ECM-receptor interaction_Homo sapiens_hsa045121.57572436
29Long-term depression_Homo sapiens_hsa047301.56910092
30Mineral absorption_Homo sapiens_hsa049781.56205613
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55467476
32Sphingolipid metabolism_Homo sapiens_hsa006001.47953795
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47582915
34Serotonergic synapse_Homo sapiens_hsa047261.46531384
35Synaptic vesicle cycle_Homo sapiens_hsa047211.45515942
36Basal cell carcinoma_Homo sapiens_hsa052171.39649740
37Retinol metabolism_Homo sapiens_hsa008301.39169693
38Selenocompound metabolism_Homo sapiens_hsa004501.38432395
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36247258
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34327868
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32886892
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31647368
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.23550326
44Sulfur metabolism_Homo sapiens_hsa009201.20084695
45Nicotine addiction_Homo sapiens_hsa050331.18514944
46Renal cell carcinoma_Homo sapiens_hsa052111.17733258
47Caffeine metabolism_Homo sapiens_hsa002321.17275903
48Melanogenesis_Homo sapiens_hsa049161.16941730
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16602485
50RNA degradation_Homo sapiens_hsa030181.14244893
51One carbon pool by folate_Homo sapiens_hsa006701.13715777
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11830225
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11119148
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.11081696
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09248965
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08782167
57Protein digestion and absorption_Homo sapiens_hsa049741.04172149
58Glutamatergic synapse_Homo sapiens_hsa047241.03450568
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02914286
60Arachidonic acid metabolism_Homo sapiens_hsa005900.98766346
61Glycerolipid metabolism_Homo sapiens_hsa005610.97324772
62GABAergic synapse_Homo sapiens_hsa047270.97321454
63Linoleic acid metabolism_Homo sapiens_hsa005910.96761379
64Amphetamine addiction_Homo sapiens_hsa050310.96086752
65Wnt signaling pathway_Homo sapiens_hsa043100.95743195
66Salivary secretion_Homo sapiens_hsa049700.95457429
67Protein export_Homo sapiens_hsa030600.95449697
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93400888
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.92620069
70* Gap junction_Homo sapiens_hsa045400.91361161
71Cholinergic synapse_Homo sapiens_hsa047250.91207079
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91174723
73Ribosome_Homo sapiens_hsa030100.90443882
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89878934
75Dilated cardiomyopathy_Homo sapiens_hsa054140.89840262
76Glutathione metabolism_Homo sapiens_hsa004800.89186423
77Cocaine addiction_Homo sapiens_hsa050300.88986014
78Gastric acid secretion_Homo sapiens_hsa049710.88440747
79Dopaminergic synapse_Homo sapiens_hsa047280.87666055
80Pancreatic secretion_Homo sapiens_hsa049720.87307613
81GnRH signaling pathway_Homo sapiens_hsa049120.86782379
82Fanconi anemia pathway_Homo sapiens_hsa034600.86711681
83Asthma_Homo sapiens_hsa053100.86383423
84Long-term potentiation_Homo sapiens_hsa047200.83829657
85Taste transduction_Homo sapiens_hsa047420.83550361
86* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83539423
87Nucleotide excision repair_Homo sapiens_hsa034200.82507777
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81849302
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81696990
90* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80808191
91Systemic lupus erythematosus_Homo sapiens_hsa053220.77833963
92Renin-angiotensin system_Homo sapiens_hsa046140.77699477
93Adherens junction_Homo sapiens_hsa045200.75355236
94Olfactory transduction_Homo sapiens_hsa047400.74408705
95* Focal adhesion_Homo sapiens_hsa045100.74346982
96Proteasome_Homo sapiens_hsa030500.73834759
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73675269
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73651660
99Renin secretion_Homo sapiens_hsa049240.73411925
100Oxytocin signaling pathway_Homo sapiens_hsa049210.73196291
101Rheumatoid arthritis_Homo sapiens_hsa053230.72877979
102Fat digestion and absorption_Homo sapiens_hsa049750.72804733
103Folate biosynthesis_Homo sapiens_hsa007900.72650765
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72244360
105Circadian entrainment_Homo sapiens_hsa047130.71731671
106DNA replication_Homo sapiens_hsa030300.70899646
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.70783971
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70703843
109TGF-beta signaling pathway_Homo sapiens_hsa043500.70115685
110Arginine and proline metabolism_Homo sapiens_hsa003300.70006609
111Bladder cancer_Homo sapiens_hsa052190.67103814
112* Ras signaling pathway_Homo sapiens_hsa040140.66947018
113ErbB signaling pathway_Homo sapiens_hsa040120.66606481
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66481469
115Dorso-ventral axis formation_Homo sapiens_hsa043200.65804094
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60985582
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58807749
118Type II diabetes mellitus_Homo sapiens_hsa049300.57932142
119Starch and sucrose metabolism_Homo sapiens_hsa005000.57779901
120Proteoglycans in cancer_Homo sapiens_hsa052050.56122873
121Estrogen signaling pathway_Homo sapiens_hsa049150.56073462
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55585874
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54634392
124Morphine addiction_Homo sapiens_hsa050320.54499406
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54429213
126Calcium signaling pathway_Homo sapiens_hsa040200.52587347
127Purine metabolism_Homo sapiens_hsa002300.51699904
128Prion diseases_Homo sapiens_hsa050200.51207006
129Histidine metabolism_Homo sapiens_hsa003400.50704591
130Circadian rhythm_Homo sapiens_hsa047100.50500569
131Phagosome_Homo sapiens_hsa041450.50379165
132* Choline metabolism in cancer_Homo sapiens_hsa052310.50356498
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49359079
134Insulin secretion_Homo sapiens_hsa049110.48636985
135RNA polymerase_Homo sapiens_hsa030200.48571852
136Endocytosis_Homo sapiens_hsa041440.48113246
137Peroxisome_Homo sapiens_hsa041460.46761902
138Mismatch repair_Homo sapiens_hsa034300.46421433
139Butanoate metabolism_Homo sapiens_hsa006500.45909432
140* Rap1 signaling pathway_Homo sapiens_hsa040150.45679748
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45324744
142beta-Alanine metabolism_Homo sapiens_hsa004100.43876382
143* Melanoma_Homo sapiens_hsa052180.43752736
144* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43739346
145* Phospholipase D signaling pathway_Homo sapiens_hsa040720.42962350
146Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42563131
147Metabolic pathways_Homo sapiens_hsa011000.42015478
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.40725251
149cAMP signaling pathway_Homo sapiens_hsa040240.40416575
150Ovarian steroidogenesis_Homo sapiens_hsa049130.38492102
151Primary bile acid biosynthesis_Homo sapiens_hsa001200.37503796
152Drug metabolism - other enzymes_Homo sapiens_hsa009830.36676137

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