PDGFB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact5.71809276
2modulation by symbiont of host immune response (GO:0052553)5.71809276
3positive regulation by symbiont of host defense response (GO:0052509)5.71809276
4modulation by symbiont of host defense response (GO:0052031)5.71809276
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.71809276
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.71809276
7microglial cell activation (GO:0001774)4.78145125
8macrophage activation involved in immune response (GO:0002281)4.40434588
9cell adhesion mediated by integrin (GO:0033627)4.16749923
10regulation of vitamin D biosynthetic process (GO:0060556)4.12216509
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.03913289
12* endothelium development (GO:0003158)3.79665047
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.74195685
14regulation of membrane protein ectodomain proteolysis (GO:0051043)3.71220705
15negative regulation of adherens junction organization (GO:1903392)3.62171915
16negative regulation of focal adhesion assembly (GO:0051895)3.62171915
17negative regulation of cell junction assembly (GO:1901889)3.62171915
18regulation of mononuclear cell migration (GO:0071675)3.57729152
19response to peptidoglycan (GO:0032494)3.56229907
20vascular endothelial growth factor signaling pathway (GO:0038084)3.51165763
21activation of MAPKKK activity (GO:0000185)3.49176785
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.46288772
23response to host immune response (GO:0052572)3.46288772
24angiogenesis involved in wound healing (GO:0060055)3.45427828
25response to muramyl dipeptide (GO:0032495)3.37361111
26positive regulation of heat generation (GO:0031652)3.35935942
27response to host (GO:0075136)3.34433114
28response to host defenses (GO:0052200)3.34433114
29response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.34433114
30regulation of interferon-beta biosynthetic process (GO:0045357)3.29432861
31endothelial tube morphogenesis (GO:0061154)3.28671885
32morphogenesis of an endothelium (GO:0003159)3.28671885
33macrophage activation (GO:0042116)3.28071772
34establishment of endothelial barrier (GO:0061028)3.26144929
35regulation of vitamin metabolic process (GO:0030656)3.24710235
36low-density lipoprotein particle clearance (GO:0034383)3.23020905
37positive regulation of vasculogenesis (GO:2001214)3.22827093
38positive regulation of macrophage cytokine production (GO:0060907)3.22489013
39regulation of fever generation (GO:0031620)3.21647785
40protein localization to endosome (GO:0036010)3.19489366
41regulation of podosome assembly (GO:0071801)3.17848024
42cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.11930457
43I-kappaB phosphorylation (GO:0007252)3.06547308
44regulation of cytokine secretion involved in immune response (GO:0002739)3.05892191
45positive regulation of chemokine biosynthetic process (GO:0045080)3.04831483
46positive regulation of endothelial cell apoptotic process (GO:2000353)3.03528840
47positive regulation of gamma-delta T cell activation (GO:0046645)3.02162242
48positive regulation of receptor recycling (GO:0001921)2.99441773
49negative regulation of blood vessel endothelial cell migration (GO:0043537)2.97573307
50lymph vessel development (GO:0001945)2.93252925
51negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.93097093
52adenosine receptor signaling pathway (GO:0001973)2.92293530
53apoptotic cell clearance (GO:0043277)2.90878464
54stress fiber assembly (GO:0043149)2.89160560
55regulation of early endosome to late endosome transport (GO:2000641)2.86763201
56retina vasculature morphogenesis in camera-type eye (GO:0061299)2.86664125
57regulation of T-helper 1 cell differentiation (GO:0045625)2.85052657
58lipopolysaccharide-mediated signaling pathway (GO:0031663)2.84509506
59positive regulation of interferon-alpha production (GO:0032727)2.83481941
60neutrophil activation involved in immune response (GO:0002283)2.83189541
61growth hormone receptor signaling pathway (GO:0060396)2.82614951
62barbed-end actin filament capping (GO:0051016)2.82446539
63regulation of nitric oxide biosynthetic process (GO:0045428)2.81594653
64negative regulation of nitric oxide biosynthetic process (GO:0045019)2.81282629
65regulation of vasculogenesis (GO:2001212)2.79441118
66regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.78412599
67positive regulation of nitric oxide biosynthetic process (GO:0045429)2.77906631
68surfactant homeostasis (GO:0043129)2.76960322
69regulation of T-helper 2 cell differentiation (GO:0045628)2.74426151
70cellular response to thyroid hormone stimulus (GO:0097067)2.73158109
71regulation of integrin activation (GO:0033623)2.72444582
72regulation of interferon-alpha production (GO:0032647)2.71313717
73regulation of cholesterol storage (GO:0010885)2.71178458
74regulation of B cell receptor signaling pathway (GO:0050855)2.71061781
75regulation of chemokine biosynthetic process (GO:0045073)2.70676454
76Notch signaling involved in heart development (GO:0061314)2.69243953
77tyrosine phosphorylation of STAT protein (GO:0007260)2.68758309
78pinocytosis (GO:0006907)2.68613292
79germinal center formation (GO:0002467)2.68236497
80regulation of interleukin-12 biosynthetic process (GO:0045075)2.67319244
81negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.67185697
82negative regulation of interleukin-12 production (GO:0032695)2.66678676
83positive regulation of steroid biosynthetic process (GO:0010893)2.65383414
84regulation of macrophage chemotaxis (GO:0010758)2.63354845
85positive regulation of odontogenesis (GO:0042482)2.63186255
86positive regulation of p38MAPK cascade (GO:1900745)2.62127066
87branching involved in labyrinthine layer morphogenesis (GO:0060670)2.61919828
88regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.61715193
89response to magnesium ion (GO:0032026)2.61518251
90germ cell migration (GO:0008354)2.59771813
91positive regulation of Cdc42 GTPase activity (GO:0043089)2.59189569
92epithelial cell-cell adhesion (GO:0090136)2.58407994
93glomerular visceral epithelial cell development (GO:0072015)2.58081986
94basement membrane organization (GO:0071711)2.56596835
95hyaluronan catabolic process (GO:0030214)2.56363875
96wound healing, spreading of epidermal cells (GO:0035313)2.56248161
97positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.56229696
98* substrate-dependent cell migration (GO:0006929)2.56061927
99regulation of chronic inflammatory response (GO:0002676)2.55401041
100vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.55200198
101myeloid dendritic cell differentiation (GO:0043011)2.54967225
102myeloid cell activation involved in immune response (GO:0002275)2.54545334
103negative regulation of granulocyte differentiation (GO:0030853)2.54143624
104response to laminar fluid shear stress (GO:0034616)2.53765511
105regulation of macrophage cytokine production (GO:0010935)2.53648858
106positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.53628198
107endothelial cell morphogenesis (GO:0001886)2.52776408
108modulation by symbiont of host cellular process (GO:0044068)2.51399418
109negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.51131744
110glycosphingolipid catabolic process (GO:0046479)2.50885807
111plasma membrane repair (GO:0001778)2.50674654
112NIK/NF-kappaB signaling (GO:0038061)2.49754500
113positive regulation of endothelial cell differentiation (GO:0045603)2.49751425
114virion attachment to host cell (GO:0019062)2.48777807
115adhesion of symbiont to host cell (GO:0044650)2.48777807
116endocytic recycling (GO:0032456)2.48740165
117JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.46862439
118mRNA transcription (GO:0009299)2.46694728
119Rap protein signal transduction (GO:0032486)2.46239789
120negative regulation of cell killing (GO:0031342)2.46141791
121negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.46141791
122dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.45760326
123T-helper 1 type immune response (GO:0042088)2.45498477
124regulation of endothelial cell differentiation (GO:0045601)2.43596110
125endothelial cell chemotaxis (GO:0035767)2.42724796
126negative regulation of cytokine production involved in immune response (GO:0002719)2.42515403
127positive regulation of antigen processing and presentation (GO:0002579)2.41734347
128patterning of blood vessels (GO:0001569)2.41515690
129lymphangiogenesis (GO:0001946)2.40727712
130negative regulation of interleukin-17 production (GO:0032700)2.40557672
131endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.40220794
132positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.40115363
133regulation of gamma-delta T cell activation (GO:0046643)2.40045670
134positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.39796294
135regulation of apoptotic process involved in morphogenesis (GO:1902337)2.38837325
136cytoskeletal anchoring at plasma membrane (GO:0007016)2.38700557
137regulation of p38MAPK cascade (GO:1900744)2.38480357
138cellular response to growth hormone stimulus (GO:0071378)2.38093044
139hemidesmosome assembly (GO:0031581)2.37353793
140adhesion of symbiont to host (GO:0044406)2.36204376
141negative regulation of lipid storage (GO:0010888)2.35519831
142ovulation from ovarian follicle (GO:0001542)2.35498563
143interferon-gamma-mediated signaling pathway (GO:0060333)2.35321065
144response to progesterone (GO:0032570)2.34594577
145blood vessel endothelial cell migration (GO:0043534)2.34547789
146regulation of gamma-delta T cell differentiation (GO:0045586)2.33372946
147response to fluid shear stress (GO:0034405)2.32766934
148positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.32707995
149regulation of heterotypic cell-cell adhesion (GO:0034114)2.32561130
150sarcoplasmic reticulum calcium ion transport (GO:0070296)2.32368078
151cell migration involved in sprouting angiogenesis (GO:0002042)2.32356608
152regulation of heat generation (GO:0031650)2.31720240
153cell-substrate junction assembly (GO:0007044)2.30950618
154positive regulation of cellular amide metabolic process (GO:0034250)2.30403278
155glomerular epithelial cell development (GO:0072310)2.29758111
156cellular response to lipopolysaccharide (GO:0071222)2.27741276
157membrane raft organization (GO:0031579)2.27474066
158semaphorin-plexin signaling pathway (GO:0071526)2.26486782
159adherens junction assembly (GO:0034333)2.26337044
160positive regulation of extracellular matrix organization (GO:1903055)2.26109522
161blood vessel maturation (GO:0001955)2.25732550
162neuron remodeling (GO:0016322)2.24802431
163immunoglobulin mediated immune response (GO:0016064)2.24767067
164wound healing, spreading of cells (GO:0044319)2.24341478
165positive regulation of astrocyte differentiation (GO:0048711)2.22426493
166monocyte differentiation (GO:0030224)2.21995039
167regulation of T cell tolerance induction (GO:0002664)2.21878844
168positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.21575098
169granulocyte activation (GO:0036230)2.21136034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.33747774
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.30949403
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.07604798
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.25106519
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.20879838
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.83246068
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.65243069
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64180650
9* IRF8_27001747_Chip-Seq_BMDM_Mouse2.56089931
10GATA2_21666600_ChIP-Seq_HMVEC_Human2.54975408
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.32848553
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31260253
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.25765370
14* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24599472
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19577814
16* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.17869620
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.15607116
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10417454
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.10357746
20* ELK3_25401928_ChIP-Seq_HUVEC_Human2.10289113
21GATA1_22025678_ChIP-Seq_K562_Human2.00171220
22CLOCK_20551151_ChIP-Seq_293T_Human1.99684605
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.94174389
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89485996
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89169540
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80858956
27RUNX_20019798_ChIP-Seq_JUKART_Human1.78573430
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74854653
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.73898701
30SPI1_23127762_ChIP-Seq_K562_Human1.71646902
31* TCF7_22412390_ChIP-Seq_EML_Mouse1.71312271
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.69511063
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67067581
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.66181724
35KDM2B_26808549_Chip-Seq_DND41_Human1.66106388
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.59656508
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56069354
38* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51615841
39VDR_24787735_ChIP-Seq_THP-1_Human1.48339355
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47489438
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46718991
42MAF_26560356_Chip-Seq_TH1_Human1.46419915
43* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43541001
44* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42870127
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42418508
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42139652
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40477937
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.37612742
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37095115
50SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36251707
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36251707
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35571164
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35061738
54* TBX20_22080862_ChIP-Seq_HEART_Mouse1.33194248
55* TBX20_22328084_ChIP-Seq_HEART_Mouse1.33194248
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32016923
57VDR_24763502_ChIP-Seq_THP-1_Human1.31729800
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.31420795
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29829283
60* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29015958
61SCL_19346495_ChIP-Seq_HPC-7_Human1.28361957
62* KDM2B_26808549_Chip-Seq_K562_Human1.26936596
63GATA1_19941826_ChIP-Seq_K562_Human1.26358406
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.26180150
65LXR_22292898_ChIP-Seq_THP-1_Human1.25762448
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.25683770
67CJUN_26792858_Chip-Seq_BT549_Human1.25325698
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24091719
69JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22810861
70* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22069372
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21612013
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21508594
73ZNF263_19887448_ChIP-Seq_K562_Human1.21209357
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21026847
75VDR_21846776_ChIP-Seq_THP-1_Human1.20770812
76* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20745116
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20549014
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20223024
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18314154
80* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17728954
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17599281
82RXR_22158963_ChIP-Seq_LIVER_Mouse1.14944343
83* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14498706
84* KDM2B_26808549_Chip-Seq_JURKAT_Human1.14064185
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.12333288
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11945716
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11908264
88* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10943050
89* RACK7_27058665_Chip-Seq_MCF-7_Human1.10485977
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09480169
91MYC_22102868_ChIP-Seq_BL_Human1.08568555
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07933941
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07495816
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07099217
95* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06849446
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06793124
97SOX2_20726797_ChIP-Seq_SW620_Human1.05748952
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.05550473
99PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04488129
100GATA2_19941826_ChIP-Seq_K562_Human1.04141511
101* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04121185
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03924044
103PU_27001747_Chip-Seq_BMDM_Mouse1.02989634
104* ATF3_27146783_Chip-Seq_COLON_Human1.02928360
105* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02755358
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02712467
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02712467
108KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02712467
109* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02507878
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02414693
111CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02309169
112ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01491674
113MYB_26560356_Chip-Seq_TH2_Human1.01189048
114P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00517828
115WT1_19549856_ChIP-ChIP_CCG9911_Human1.00194914
116PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00187513
117SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00043122
118ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99782103
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99747750
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98675773
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97779660
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97662351
123SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96987393
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96779704
125SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96300127
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95862408
127* UTX_26944678_Chip-Seq_JUKART_Human0.95782607
128RUNX1_22412390_ChIP-Seq_EML_Mouse0.95646171
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.95370047
130NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94832042
131RUNX1_27514584_Chip-Seq_MCF-7_Human0.94738256
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93492739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.65601950
2* MP0005167_abnormal_blood-brain_barrier3.16187683
3MP0010368_abnormal_lymphatic_system3.07431677
4MP0003300_gastrointestinal_ulcer3.01223518
5MP0001879_abnormal_lymphatic_vessel2.88014900
6MP0003191_abnormal_cellular_cholesterol2.75946564
7MP0004510_myositis2.69382953
8MP0003828_pulmonary_edema2.63818789
9MP0003566_abnormal_cell_adhesion2.42578844
10MP0003436_decreased_susceptibility_to2.41832936
11MP0003705_abnormal_hypodermis_morpholog2.32830992
12MP0003724_increased_susceptibility_to2.26378851
13MP0005451_abnormal_body_composition2.20077522
14MP0004084_abnormal_cardiac_muscle2.19188898
15MP0004272_abnormal_basement_membrane2.10210458
16MP0006082_CNS_inflammation2.06810479
17MP0009785_altered_susceptibility_to2.00945404
18MP0000343_altered_response_to1.94071164
19MP0003091_abnormal_cell_migration1.94064986
20MP0002138_abnormal_hepatobiliary_system1.92439754
21MP0009278_abnormal_bone_marrow1.92334506
22MP0001835_abnormal_antigen_presentation1.80647005
23MP0003075_altered_response_to1.76790216
24MP0008004_abnormal_stomach_pH1.76204074
25MP0005058_abnormal_lysosome_morphology1.73543044
26MP0002419_abnormal_innate_immunity1.73401965
27MP0002877_abnormal_melanocyte_morpholog1.70994905
28MP0005387_immune_system_phenotype1.70164818
29MP0001790_abnormal_immune_system1.70164818
30MP0004233_abnormal_muscle_weight1.66795353
31MP0005000_abnormal_immune_tolerance1.64244533
32MP0001533_abnormal_skeleton_physiology1.64053888
33MP0003448_altered_tumor_morphology1.62666071
34* MP0000767_abnormal_smooth_muscle1.61579509
35MP0005409_darkened_coat_color1.59824555
36MP0002148_abnormal_hypersensitivity_rea1.57298042
37MP0001545_abnormal_hematopoietic_system1.56224677
38MP0005397_hematopoietic_system_phenotyp1.56224677
39MP0005671_abnormal_response_to1.55957049
40MP0000685_abnormal_immune_system1.54937526
41MP0005165_increased_susceptibility_to1.53748305
42MP0002452_abnormal_antigen_presenting1.50702636
43MP0001849_ear_inflammation1.50198157
44MP0001853_heart_inflammation1.49653392
45MP0005464_abnormal_platelet_physiology1.48655625
46MP0002332_abnormal_exercise_endurance1.48235450
47MP0005595_abnormal_vascular_smooth1.43610971
48MP0005025_abnormal_response_to1.42841585
49MP0003172_abnormal_lysosome_physiology1.42748836
50MP0005666_abnormal_adipose_tissue1.42102708
51MP0002139_abnormal_hepatobiliary_system1.42037824
52MP0004130_abnormal_muscle_cell1.40682349
53MP0003045_fibrosis1.37675621
54MP0006054_spinal_hemorrhage1.36917597
55* MP0000249_abnormal_blood_vessel1.36290629
56MP0002723_abnormal_immune_serum1.34951883
57MP0001800_abnormal_humoral_immune1.31887900
58MP0010352_gastrointestinal_tract_polyps1.28600005
59MP0010155_abnormal_intestine_physiology1.28508781
60MP0005375_adipose_tissue_phenotype1.27440918
61MP0001958_emphysema1.27260662
62MP0002972_abnormal_cardiac_muscle1.27193169
63MP0005023_abnormal_wound_healing1.26855425
64MP0002998_abnormal_bone_remodeling1.26200451
65MP0001819_abnormal_immune_cell1.23525323
66MP0005076_abnormal_cell_differentiation1.23339441
67MP0002796_impaired_skin_barrier1.22121763
68MP0004185_abnormal_adipocyte_glucose1.21724049
69MP0002405_respiratory_system_inflammati1.21653170
70MP0000751_myopathy1.21278765
71MP0002420_abnormal_adaptive_immunity1.20782223
72MP0010234_abnormal_vibrissa_follicle1.20551301
73* MP0001544_abnormal_cardiovascular_syste1.19392485
74* MP0005385_cardiovascular_system_phenoty1.19392485
75MP0005623_abnormal_meninges_morphology1.19292784
76MP0002933_joint_inflammation1.17733436
77MP0005166_decreased_susceptibility_to1.16987483
78MP0002166_altered_tumor_susceptibility1.16325542
79MP0000750_abnormal_muscle_regeneration1.16247341
80MP0009780_abnormal_chondrocyte_physiolo1.15908490
81MP0009840_abnormal_foam_cell1.15296912
82MP0010630_abnormal_cardiac_muscle1.14118637
83MP0004036_abnormal_muscle_relaxation1.13372123
84MP0004947_skin_inflammation1.12676946
85MP0005330_cardiomyopathy1.11268195
86MP0001851_eye_inflammation1.10713691
87MP0003453_abnormal_keratinocyte_physiol1.09686227
88MP0002254_reproductive_system_inflammat1.09335165
89MP0008775_abnormal_heart_ventricle1.08987629
90MP0008260_abnormal_autophagy1.06344092
91MP0004808_abnormal_hematopoietic_stem1.06234589
92MP0001845_abnormal_inflammatory_respons1.04859689
93MP0004782_abnormal_surfactant_physiolog1.04814626
94MP0002925_abnormal_cardiovascular_devel1.03083182
95MP0000465_gastrointestinal_hemorrhage1.01482063
96MP0004484_altered_response_of1.00408096
97MP0004087_abnormal_muscle_fiber0.97913351
98* MP0003279_aneurysm0.96953678
99* MP0001614_abnormal_blood_vessel0.95753221
100MP0008469_abnormal_protein_level0.95457557
101* MP0002128_abnormal_blood_circulation0.94773700
102MP0002928_abnormal_bile_duct0.94544693
103MP0009333_abnormal_splenocyte_physiolog0.93338377
104MP0003690_abnormal_glial_cell0.91488822
105MP0000604_amyloidosis0.91403876
106MP0002295_abnormal_pulmonary_circulatio0.90398191
107* MP0006138_congestive_heart_failure0.89938791
108MP0000733_abnormal_muscle_development0.89122478
109MP0004858_abnormal_nervous_system0.88638567
110MP0000749_muscle_degeneration0.88468003
111MP0008438_abnormal_cutaneous_collagen0.88219635
112MP0003941_abnormal_skin_development0.87188863
113MP0000858_altered_metastatic_potential0.87183118
114MP0003950_abnormal_plasma_membrane0.85913931
115MP0009764_decreased_sensitivity_to0.85572812
116MP0005164_abnormal_response_to0.84611661
117MP0005257_abnormal_intraocular_pressure0.84059668
118MP0002006_tumorigenesis0.83518697
119MP0005670_abnormal_white_adipose0.83390664
120MP0008874_decreased_physiological_sensi0.81033371
121* MP0001915_intracranial_hemorrhage0.79639665
122MP0005390_skeleton_phenotype0.78768510
123MP0003329_amyloid_beta_deposits0.78424826
124MP0002896_abnormal_bone_mineralization0.78322997
125MP0001727_abnormal_embryo_implantation0.74900271
126MP0000003_abnormal_adipose_tissue0.71473869
127MP0000747_muscle_weakness0.71151837
128MP0004883_abnormal_blood_vessel0.66697899

Predicted human phenotypes

RankGene SetZ-score
1Hematochezia (HP:0002573)5.20262893
2Cerebral aneurysm (HP:0004944)4.20999932
3Systemic lupus erythematosus (HP:0002725)4.14790636
4Polycythemia (HP:0001901)4.00379920
5Nuclear cataract (HP:0100018)3.84723205
6Eczematoid dermatitis (HP:0000976)3.83531228
7Increased cerebral lipofuscin (HP:0011813)3.79266166
8Esophageal varix (HP:0002040)3.78694461
9Recurrent abscess formation (HP:0002722)3.51750208
10Spontaneous hematomas (HP:0007420)3.40118798
11Arterial tortuosity (HP:0005116)3.36996675
12Myocardial infarction (HP:0001658)3.35387177
13Glomerulonephritis (HP:0000099)3.29329258
14Loss of speech (HP:0002371)3.29142230
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.21312412
16Axonal loss (HP:0003447)3.13000931
17Interstitial pulmonary disease (HP:0006530)3.09741527
18Abnormality of polysaccharide metabolism (HP:0011012)3.07034529
19Abnormality of glycosaminoglycan metabolism (HP:0004371)3.07034529
20Abnormality of mucopolysaccharide metabolism (HP:0011020)3.07034529
21Neurofibrillary tangles (HP:0002185)3.07028232
22Increased connective tissue (HP:0009025)3.04586761
23Urinary glycosaminoglycan excretion (HP:0003541)3.04394162
24Vascular tortuosity (HP:0004948)3.00605391
25Muscle fiber splitting (HP:0003555)2.89806078
26Abnormality of glycosphingolipid metabolism (HP:0004343)2.87121956
27Abnormality of glycolipid metabolism (HP:0010969)2.87121956
28Abnormality of liposaccharide metabolism (HP:0010968)2.87121956
29Urethral obstruction (HP:0000796)2.79796225
30Aortic aneurysm (HP:0004942)2.73780527
31Abnormality of macrophages (HP:0004311)2.73574343
32Recurrent bacterial skin infections (HP:0005406)2.70274100
33Nephritis (HP:0000123)2.68161340
34Cerebral inclusion bodies (HP:0100314)2.66395753
35J-shaped sella turcica (HP:0002680)2.60562368
36Disinhibition (HP:0000734)2.59301351
37Protrusio acetabuli (HP:0003179)2.57875229
38Hyporeflexia of lower limbs (HP:0002600)2.56124655
39Sudden death (HP:0001699)2.53402375
40Thick nail (HP:0001805)2.47990269
41Difficulty climbing stairs (HP:0003551)2.45999066
42Colitis (HP:0002583)2.44933446
43Mediastinal lymphadenopathy (HP:0100721)2.42868791
44Ventricular tachycardia (HP:0004756)2.41263121
45Cervical subluxation (HP:0003308)2.41019764
46Mucosal telangiectasiae (HP:0100579)2.35761894
47Cerebral hemorrhage (HP:0001342)2.34963336
48Osteolytic defects of the hand bones (HP:0009699)2.33539166
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.33539166
50Distal lower limb muscle weakness (HP:0009053)2.32647240
51Abnormality of the nasal mucosa (HP:0000433)2.31563463
52Asymmetric septal hypertrophy (HP:0001670)2.31266067
53Inflammation of the large intestine (HP:0002037)2.29931780
54Tetraparesis (HP:0002273)2.29595935
55Spinal rigidity (HP:0003306)2.28194847
56Bulbar palsy (HP:0001283)2.28165930
57Hemorrhage of the eye (HP:0011885)2.26541312
58Menorrhagia (HP:0000132)2.26516862
59Mitral valve prolapse (HP:0001634)2.24832418
60Dysostosis multiplex (HP:0000943)2.23165382
61Camptodactyly of toe (HP:0001836)2.22415149
62Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.21768321
63Stroke (HP:0001297)2.21572820
64Bicuspid aortic valve (HP:0001647)2.21074423
65Difficulty running (HP:0009046)2.20720785
66Fatigue (HP:0012378)2.20287085
67Striae distensae (HP:0001065)2.18923533
68Distal lower limb amyotrophy (HP:0008944)2.18744590
69Purpura (HP:0000979)2.18021823
70Frequent falls (HP:0002359)2.16834634
71Exercise-induced muscle cramps (HP:0003710)2.15976877
72Thin bony cortex (HP:0002753)2.15588545
73Mutism (HP:0002300)2.14973852
74Conjunctival telangiectasia (HP:0000524)2.13681260
75Gastrointestinal inflammation (HP:0004386)2.13432785
76Broad face (HP:0000283)2.10947559
77Xerostomia (HP:0000217)2.09530179
78Vertebral compression fractures (HP:0002953)2.09318775
79Aneurysm (HP:0002617)2.08237667
80Recurrent gram-negative bacterial infections (HP:0005420)2.08032787
81Adactyly (HP:0009776)2.06995260
82Rapidly progressive (HP:0003678)2.06843817
83Flat acetabular roof (HP:0003180)2.05148903
84Milia (HP:0001056)2.03799679
85Porencephaly (HP:0002132)2.03529980
86Absent hand (HP:0004050)2.02940405
87Elevated erythrocyte sedimentation rate (HP:0003565)2.02435915
88Right ventricular cardiomyopathy (HP:0011663)2.02158187
89Lymphangioma (HP:0100764)2.01707234
90Skull defect (HP:0001362)2.01436824
91Gingivitis (HP:0000230)2.00330545
92Pulmonary infiltrates (HP:0002113)1.99737655
93Persistence of primary teeth (HP:0006335)1.99048023
94Complement deficiency (HP:0004431)1.98237218
95Amyloidosis (HP:0011034)1.98129036
96EMG: myopathic abnormalities (HP:0003458)1.96898460
97Stomatitis (HP:0010280)1.96636913
98Increased serum ferritin (HP:0003281)1.96425881
99Myositis (HP:0100614)1.95736814
100Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95705448
101Facial diplegia (HP:0001349)1.95338453
102Scapular winging (HP:0003691)1.93484348
103Reduced subcutaneous adipose tissue (HP:0003758)1.93277582
104Neonatal death (HP:0003811)1.92856320
105Subaortic stenosis (HP:0001682)1.92853233
106Abnormality of the left ventricular outflow tract (HP:0011103)1.92853233
107Achilles tendon contracture (HP:0001771)1.92770506
108Neuronal loss in central nervous system (HP:0002529)1.91651435
109Disproportionate tall stature (HP:0001519)1.91365173
110Arterial thrombosis (HP:0004420)1.90773120
111Centrally nucleated skeletal muscle fibers (HP:0003687)1.89877062
112Joint contractures involving the joints of the feet (HP:0100492)1.89482870
113Flexion contracture of toe (HP:0005830)1.89482870
114Polygenic inheritance (HP:0010982)1.89108285
115Aortic dissection (HP:0002647)1.88775581
116Premature rupture of membranes (HP:0001788)1.88360134
117Recurrent fungal infections (HP:0002841)1.87937805
118Nonimmune hydrops fetalis (HP:0001790)1.87828861
119Vacuolated lymphocytes (HP:0001922)1.86207747
120Focal segmental glomerulosclerosis (HP:0000097)1.85653544
121Wrist flexion contracture (HP:0001239)1.85453570
122Orchitis (HP:0100796)1.83499922
123Bone cyst (HP:0012062)1.83363518
124Impaired platelet aggregation (HP:0003540)1.82989353
125Abnormal platelet function (HP:0011869)1.82989353
126Abnormality of the Achilles tendon (HP:0005109)1.82097548
127Prolonged neonatal jaundice (HP:0006579)1.80684540
128Atrial fibrillation (HP:0005110)1.80442521
129Portal hypertension (HP:0001409)1.79316981
130Increased density of long bones (HP:0006392)1.78996301
131Autoimmune thrombocytopenia (HP:0001973)1.78803802
132Visceral angiomatosis (HP:0100761)1.78770060
133Pulmonary hypertension (HP:0002092)1.78506632
134Distal upper limb amyotrophy (HP:0007149)1.78429516
135Upper limb amyotrophy (HP:0009129)1.78429516
136Joint stiffness (HP:0001387)1.78305564
137Abnormality of complement system (HP:0005339)1.77309714
138Lower limb amyotrophy (HP:0007210)1.77295142
139Hyperparathyroidism (HP:0000843)1.75383898
140Mucopolysacchariduria (HP:0008155)1.75307112
141Prolonged bleeding time (HP:0003010)1.74458810
142Joint hemorrhage (HP:0005261)1.73900365
143Progressive neurologic deterioration (HP:0002344)1.73363238
144Epistaxis (HP:0000421)1.71547304
145Bone pain (HP:0002653)1.70918599
146Abnormality of skeletal muscle fiber size (HP:0012084)1.69046860
147Increased variability in muscle fiber diameter (HP:0003557)1.67001151
148Abnormality of the hepatic vasculature (HP:0006707)1.66763250
149Hemangiomatosis (HP:0007461)1.62294449
150Diaphragmatic weakness (HP:0009113)1.61207603
151Pathologic fracture (HP:0002756)1.60484431

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR25.05162508
2TIE14.12918923
3TTN3.50919004
4RIPK13.27292012
5MAP3K142.76638187
6KDR2.67795946
7TRIB32.44811547
8TBK12.24405831
9DDR22.17818165
10PAK42.14471019
11TYK22.14393583
12EPHB12.03102240
13TAOK21.95917386
14PKN21.95825479
15MAP2K31.90621322
16JAK31.88065859
17SIK11.85654655
18TESK11.83206782
19PTK61.81054352
20RIPK41.78028577
21MAP4K11.76360911
22DMPK1.74309727
23LATS21.69741902
24PTK2B1.61039877
25MAP3K31.55909955
26EPHA21.44242489
27ERN11.43553095
28IRAK31.42789654
29PRPF4B1.40910177
30TGFBR11.38778368
31JAK11.36824956
32MAP3K111.36357780
33ZAP701.36152398
34CSK1.29339806
35CDC42BPA1.25243837
36ICK1.23518591
37STK101.17880182
38MAPK151.09205046
39PTK21.01839879
40CSF1R1.01096069
41IKBKB1.00574509
42IKBKE0.99812182
43TYRO30.96481623
44PDGFRA0.95488744
45MAP3K100.93872264
46LRRK20.93116875
47GRK70.92594322
48ABL20.92560732
49EPHB20.91528474
50CAMK1D0.91294048
51HCK0.91097582
52SMG10.90697537
53ARAF0.90393186
54CHUK0.88016600
55MAPK120.85487906
56FER0.83571781
57JAK20.81709604
58TAOK10.81077977
59MAP3K10.80314883
60FGFR40.78491158
61PRKG20.77415821
62RPS6KA20.77195601
63MARK30.76483694
64FES0.76132066
65MAPKAPK30.75056953
66IRAK40.74494344
67CAMK1G0.73682833
68EGFR0.72672446
69LIMK10.72241241
70PDGFRB0.72154737
71NTRK10.71631391
72FGFR30.71305765
73PAK20.70876642
74BLK0.70179469
75FGR0.70090573
76STK240.69312777
77NEK90.69161494
78SIK30.68506342
79IRAK20.67963372
80PRKD10.67697140
81TRPM70.66883020
82BMX0.65524717
83ITK0.65431882
84KIT0.64722239
85MATK0.64406777
86LCK0.63890609
87RPS6KA40.62023836
88GSK3A0.59396008
89MST1R0.58567447
90TSSK60.58557717
91DAPK30.56945878
92TXK0.56272241
93DAPK20.55700973
94MAPKAPK20.54503937
95MAP3K120.54043198
96MYLK0.53767001
97EEF2K0.52901952
98ERBB40.51572467
99ILK0.51515659
100PRKCH0.51142647
101CDK60.50964967
102PDK20.50912671
103MAP3K50.50687885
104CDK120.50007848
105RET0.49794760
106TESK20.48900861
107INSR0.48613521
108ABL10.48389158
109MOS0.47874582
110MAP3K90.47097176
111MARK20.46757872
112IGF1R0.46639398
113MET0.46610737
114IRAK10.45476977
115MAP3K130.45325080
116RPS6KC10.44184873
117RPS6KL10.44184873
118MTOR0.43544262
119SIK20.43185990
120PDPK10.43163931
121CAMK2G0.42902589
122NME20.42723640
123MAP3K70.41495318
124MAPK40.41311698
125MAP2K20.41173503
126CAMKK10.41074856
127ALK0.39723828
128SRC0.39416493
129STK30.39105632
130BMPR20.38633918
131ROCK20.38041161
132MUSK0.36688755
133PIM20.34467552
134PRKAA20.33888202
135PDK10.33011446
136PRKD30.31927136
137MAP3K60.31381048
138ROCK10.29355065

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.40549147
2Osteoclast differentiation_Homo sapiens_hsa043802.22736352
3Staphylococcus aureus infection_Homo sapiens_hsa051502.04722142
4Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93001760
5Toxoplasmosis_Homo sapiens_hsa051451.87004617
6Pertussis_Homo sapiens_hsa051331.76810472
7Viral myocarditis_Homo sapiens_hsa054161.74841319
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.74765339
9Leukocyte transendothelial migration_Homo sapiens_hsa046701.73399663
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.71316695
11Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.66450398
12Malaria_Homo sapiens_hsa051441.62725304
13TNF signaling pathway_Homo sapiens_hsa046681.61868590
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56085899
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.55548376
16Bladder cancer_Homo sapiens_hsa052191.55286712
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.50400790
18Dilated cardiomyopathy_Homo sapiens_hsa054141.47083113
19Salmonella infection_Homo sapiens_hsa051321.45626856
20Legionellosis_Homo sapiens_hsa051341.44733990
21B cell receptor signaling pathway_Homo sapiens_hsa046621.44549222
22Tuberculosis_Homo sapiens_hsa051521.43078141
23Amoebiasis_Homo sapiens_hsa051461.42784754
24Measles_Homo sapiens_hsa051621.41183388
25Adherens junction_Homo sapiens_hsa045201.39869774
26* Focal adhesion_Homo sapiens_hsa045101.39576646
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36992890
28Shigellosis_Homo sapiens_hsa051311.36105562
29Graft-versus-host disease_Homo sapiens_hsa053321.34488222
30Rheumatoid arthritis_Homo sapiens_hsa053231.29911286
31Lysosome_Homo sapiens_hsa041421.29896603
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29895902
33ECM-receptor interaction_Homo sapiens_hsa045121.26168968
34Small cell lung cancer_Homo sapiens_hsa052221.25445450
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24247953
36VEGF signaling pathway_Homo sapiens_hsa043701.23687310
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23314909
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21946903
39Chronic myeloid leukemia_Homo sapiens_hsa052201.21588553
40Platelet activation_Homo sapiens_hsa046111.20761100
41Proteoglycans in cancer_Homo sapiens_hsa052051.17978926
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17518820
43Hematopoietic cell lineage_Homo sapiens_hsa046401.17224624
44Influenza A_Homo sapiens_hsa051641.16794280
45Complement and coagulation cascades_Homo sapiens_hsa046101.16011625
46Chemokine signaling pathway_Homo sapiens_hsa040621.11223289
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05327019
48* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03734646
49Apoptosis_Homo sapiens_hsa042101.03392546
50Phagosome_Homo sapiens_hsa041451.03261214
51Pancreatic cancer_Homo sapiens_hsa052121.02096083
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00892070
53Antigen processing and presentation_Homo sapiens_hsa046120.99157427
54HIF-1 signaling pathway_Homo sapiens_hsa040660.98569851
55African trypanosomiasis_Homo sapiens_hsa051430.98215885
56Other glycan degradation_Homo sapiens_hsa005110.97596696
57Dorso-ventral axis formation_Homo sapiens_hsa043200.97237102
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.96324955
59Notch signaling pathway_Homo sapiens_hsa043300.95037593
60* Renal cell carcinoma_Homo sapiens_hsa052110.94904024
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.94569145
62* Rap1 signaling pathway_Homo sapiens_hsa040150.94538146
63Vibrio cholerae infection_Homo sapiens_hsa051100.93699713
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93356300
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92371566
66Galactose metabolism_Homo sapiens_hsa000520.91407142
67Endocytosis_Homo sapiens_hsa041440.91151115
68Prion diseases_Homo sapiens_hsa050200.90718748
69T cell receptor signaling pathway_Homo sapiens_hsa046600.90482764
70Allograft rejection_Homo sapiens_hsa053300.89677051
71Hepatitis B_Homo sapiens_hsa051610.89611838
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88238145
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.86254995
74* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85383268
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82623662
76Acute myeloid leukemia_Homo sapiens_hsa052210.80881491
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79291146
78Hepatitis C_Homo sapiens_hsa051600.78859666
79PPAR signaling pathway_Homo sapiens_hsa033200.75437442
80Sphingolipid metabolism_Homo sapiens_hsa006000.75283341
81Insulin resistance_Homo sapiens_hsa049310.74860395
82Asthma_Homo sapiens_hsa053100.73781786
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71843076
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71765395
85Prolactin signaling pathway_Homo sapiens_hsa049170.71390381
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.68183232
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67752651
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.66460281
89* MAPK signaling pathway_Homo sapiens_hsa040100.65561519
90* HTLV-I infection_Homo sapiens_hsa051660.65241606
91Fructose and mannose metabolism_Homo sapiens_hsa000510.64140205
92Insulin signaling pathway_Homo sapiens_hsa049100.63686268
93Estrogen signaling pathway_Homo sapiens_hsa049150.62893520
94Herpes simplex infection_Homo sapiens_hsa051680.62675803
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62074594
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61426132
97GnRH signaling pathway_Homo sapiens_hsa049120.61412024
98Type I diabetes mellitus_Homo sapiens_hsa049400.60115601
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58311737
100* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56180926
101Pentose phosphate pathway_Homo sapiens_hsa000300.55799355
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54685774
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54586665
104Type II diabetes mellitus_Homo sapiens_hsa049300.53235465
105Tight junction_Homo sapiens_hsa045300.53192096
106Oxytocin signaling pathway_Homo sapiens_hsa049210.52713104
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52693252
108* Phospholipase D signaling pathway_Homo sapiens_hsa040720.52480312
109* MicroRNAs in cancer_Homo sapiens_hsa052060.52376841
110Renin secretion_Homo sapiens_hsa049240.52021326
111FoxO signaling pathway_Homo sapiens_hsa040680.51711406
112* Pathways in cancer_Homo sapiens_hsa052000.50751035
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50481938
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49750552
115Colorectal cancer_Homo sapiens_hsa052100.49403161
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49197021
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49022405
118ErbB signaling pathway_Homo sapiens_hsa040120.48075088
119Endometrial cancer_Homo sapiens_hsa052130.42007534
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.40250991

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