PDGFD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucocorticoid biosynthetic process (GO:0006704)9.31577048
2glucocorticoid metabolic process (GO:0008211)6.45279065
3C21-steroid hormone biosynthetic process (GO:0006700)6.06738942
4cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.17633315
5vascular endothelial growth factor signaling pathway (GO:0038084)5.16531310
6substrate-dependent cell migration (GO:0006929)5.05222652
7lymph vessel development (GO:0001945)5.00819643
8androgen biosynthetic process (GO:0006702)4.97651236
9cellular response to epinephrine stimulus (GO:0071872)4.77171700
10progesterone metabolic process (GO:0042448)4.61818984
11C21-steroid hormone metabolic process (GO:0008207)4.47183734
12response to follicle-stimulating hormone (GO:0032354)4.46208118
13keratan sulfate catabolic process (GO:0042340)4.39615651
14retina vasculature morphogenesis in camera-type eye (GO:0061299)4.39098937
15cardiac myofibril assembly (GO:0055003)4.37889670
16extracellular fibril organization (GO:0043206)4.34899753
17regulation of metalloenzyme activity (GO:0048552)4.33036194
18response to epinephrine (GO:0071871)4.28748037
19cell migration involved in sprouting angiogenesis (GO:0002042)4.26851402
20cellular response to antibiotic (GO:0071236)4.26152078
21cell migration involved in heart development (GO:0060973)4.16813871
22endothelium development (GO:0003158)4.07541544
23blood vessel maturation (GO:0001955)4.06696575
24chondrocyte proliferation (GO:0035988)4.00722091
25neuron projection extension involved in neuron projection guidance (GO:1902284)3.96929848
26axon extension involved in axon guidance (GO:0048846)3.96929848
27vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.93906936
28regulation of cardioblast differentiation (GO:0051890)3.86794460
29lymphangiogenesis (GO:0001946)3.86288072
30cellular response to gonadotropin stimulus (GO:0071371)3.80303972
31myofibril assembly (GO:0030239)3.76271463
32collagen fibril organization (GO:0030199)3.75722168
33endothelial cell morphogenesis (GO:0001886)3.73546945
34fibril organization (GO:0097435)3.70400955
35positive regulation of receptor recycling (GO:0001921)3.65540607
36cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.62899056
37regulation of apoptotic cell clearance (GO:2000425)3.62462291
38apoptotic cell clearance (GO:0043277)3.62340786
39regulation of steroid hormone biosynthetic process (GO:0090030)3.53678449
40adhesion of symbiont to host cell (GO:0044650)3.47665645
41virion attachment to host cell (GO:0019062)3.47665645
42cell adhesion mediated by integrin (GO:0033627)3.47580910
43membrane raft organization (GO:0031579)3.43423318
44blood vessel endothelial cell migration (GO:0043534)3.43295406
45estrogen biosynthetic process (GO:0006703)3.37920447
46negative regulation of protein localization to cell surface (GO:2000009)3.33593054
47bone trabecula formation (GO:0060346)3.32524087
48aggressive behavior (GO:0002118)3.26338705
49negative regulation of endothelial cell proliferation (GO:0001937)3.23646506
50adhesion of symbiont to host (GO:0044406)3.13701223
51membrane assembly (GO:0071709)3.10983900
52regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.10272839
53regulation of the force of heart contraction (GO:0002026)3.09863488
54extracellular matrix assembly (GO:0085029)3.08449095
55artery development (GO:0060840)3.07801254
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07581240
57positive regulation of endothelial cell migration (GO:0010595)3.06632799
58regulation of glomerular filtration (GO:0003093)3.05216265
59negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.04277910
60adrenal gland development (GO:0030325)3.04275910
61regulation of tight junction assembly (GO:2000810)3.02494532
62cellular response to vitamin (GO:0071295)3.02274654
63hormone biosynthetic process (GO:0042446)2.99385600
64regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.97110994
65sequestering of extracellular ligand from receptor (GO:0035581)2.96383334
66regulation of cardiac muscle cell contraction (GO:0086004)2.94493703
67peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.92329285
68potassium ion import (GO:0010107)2.90572253
69positive regulation of hormone biosynthetic process (GO:0046886)2.89202356
70positive regulation of extracellular matrix organization (GO:1903055)2.88819489
71response to water (GO:0009415)2.88686019
72regulation of transforming growth factor beta2 production (GO:0032909)2.87251233
73hypotonic response (GO:0006971)2.87090714
74negative regulation of nitric-oxide synthase activity (GO:0051001)2.86554900
75protein localization to cell surface (GO:0034394)2.85783859
76induction of positive chemotaxis (GO:0050930)2.82302370
77phagocytosis, recognition (GO:0006910)2.81686251
78positive regulation of blood vessel endothelial cell migration (GO:0043536)2.81142288
79regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.79557624
80regulation of endothelial cell differentiation (GO:0045601)2.79396770
81positive regulation of male gonad development (GO:2000020)2.78283355
82metanephric nephron epithelium development (GO:0072243)2.78126714
83pericardium development (GO:0060039)2.77458635
84cell communication by electrical coupling (GO:0010644)2.76826644
85cardiac muscle hypertrophy (GO:0003300)2.76168497
86heart trabecula formation (GO:0060347)2.76079110
87response to gonadotropin (GO:0034698)2.75911192
88dermatan sulfate biosynthetic process (GO:0030208)2.73604403
89negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.73456239
90cellular response to vitamin D (GO:0071305)2.73387723
91endodermal cell differentiation (GO:0035987)2.73199088
92renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.72486212
93cellular response to growth hormone stimulus (GO:0071378)2.71794343
94protein heterotrimerization (GO:0070208)2.71690091
95positive regulation of epithelial cell migration (GO:0010634)2.71559219
96negative regulation of cartilage development (GO:0061037)2.71405460
97cellular response to toxic substance (GO:0097237)2.71330151
98Leydig cell differentiation (GO:0033327)2.70518638
99striated muscle hypertrophy (GO:0014897)2.70183837
100blood vessel remodeling (GO:0001974)2.68506580
101cell proliferation involved in metanephros development (GO:0072203)2.68452479
102response to vitamin E (GO:0033197)2.68202005
103positive regulation of endothelial cell apoptotic process (GO:2000353)2.67762898
104mammary gland development (GO:0030879)2.67388285
105sarcomere organization (GO:0045214)2.66977142
106regulation of integrin-mediated signaling pathway (GO:2001044)2.65562261
107biotin metabolic process (GO:0006768)2.65379071
108negative regulation of anoikis (GO:2000811)2.64657009
109metanephric tubule development (GO:0072170)2.64370972
110metanephric nephron tubule development (GO:0072234)2.64370972
111trabecula formation (GO:0060343)2.64219077
112cell differentiation involved in metanephros development (GO:0072202)2.61756606
113regulation of actin filament-based movement (GO:1903115)2.61753784
114polyketide metabolic process (GO:0030638)2.61050562
115doxorubicin metabolic process (GO:0044598)2.61050562
116daunorubicin metabolic process (GO:0044597)2.61050562
117metanephric mesenchyme development (GO:0072075)2.60962489
118muscle hypertrophy (GO:0014896)2.60869624
119regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.60635105
120metanephric epithelium development (GO:0072207)2.60335625
121type B pancreatic cell proliferation (GO:0044342)2.60330610
122wound healing, spreading of epidermal cells (GO:0035313)2.60068125
123dermatan sulfate metabolic process (GO:0030205)2.59310595
124regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.58915944
125actomyosin structure organization (GO:0031032)2.57722594
126cellular sodium ion homeostasis (GO:0006883)2.57370011
127venous blood vessel morphogenesis (GO:0048845)2.56984361
128sprouting angiogenesis (GO:0002040)2.56378343
129renal system process involved in regulation of blood volume (GO:0001977)2.56301061
130complement activation, alternative pathway (GO:0006957)2.56074436
131endothelial cell migration (GO:0043542)2.55845120
132glomerular basement membrane development (GO:0032836)2.54796673
133smooth muscle tissue development (GO:0048745)2.54496429
134regulation of endothelial cell migration (GO:0010594)2.54483593
135mesenchymal-epithelial cell signaling (GO:0060638)2.53961963
136epithelial cell-cell adhesion (GO:0090136)2.53845137
137endothelial cell chemotaxis (GO:0035767)2.53477816
138negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.52132474
139sodium ion export (GO:0071436)2.51964164
140patterning of blood vessels (GO:0001569)2.51909755
141toxin metabolic process (GO:0009404)2.51607051
142cardiac chamber formation (GO:0003207)2.51490817
143relaxation of cardiac muscle (GO:0055119)2.50636414
144kidney mesenchyme development (GO:0072074)2.50509137
145collagen catabolic process (GO:0030574)2.49872229
146tonic smooth muscle contraction (GO:0014820)2.49746984
147nephron epithelium development (GO:0072009)2.47714659
148regulation of complement activation (GO:0030449)2.47331798
149regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.47284366
150negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.46848763
151response to fluid shear stress (GO:0034405)2.46206879
152negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45027207
153embryonic heart tube development (GO:0035050)2.44871826
154protein targeting to plasma membrane (GO:0072661)2.44751821
155multicellular organismal macromolecule metabolic process (GO:0044259)2.44626728
156collagen metabolic process (GO:0032963)2.42936678
157coronary vasculature morphogenesis (GO:0060977)2.42737559
158cardiac muscle cell development (GO:0055013)2.41557155
159negative regulation of viral entry into host cell (GO:0046597)2.41492543
160Notch signaling involved in heart development (GO:0061314)2.41200842
161cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.40753352
162cardiac muscle contraction (GO:0060048)2.40577448
163branched-chain amino acid catabolic process (GO:0009083)2.39766650
164basement membrane organization (GO:0071711)2.39370574
165blood vessel morphogenesis (GO:0048514)2.39149412
166skin morphogenesis (GO:0043589)2.39113852
167positive regulation of positive chemotaxis (GO:0050927)2.39097049
168androgen metabolic process (GO:0008209)2.38842274
169maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.38735464
170negative regulation of chondrocyte differentiation (GO:0032331)2.38617674
171response to leptin (GO:0044321)2.37910418
172multicellular organismal metabolic process (GO:0044236)2.36707348
173cell proliferation involved in kidney development (GO:0072111)2.36475132
174regulation of female receptivity (GO:0045924)2.35978552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.01658505
2CLOCK_20551151_ChIP-Seq_293T_Human3.31197916
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.13862222
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.84276615
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.77374411
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.54672875
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.54602263
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.49314430
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.47159257
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.41572700
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.37461202
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.30985757
13GATA2_21666600_ChIP-Seq_HMVEC_Human2.26187118
14* CJUN_26792858_Chip-Seq_BT549_Human2.21457352
15CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.17426802
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.16816464
17CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.14569637
18NRF2_20460467_ChIP-Seq_MEFs_Mouse2.08087213
19NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.08087213
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.07576360
21PPAR_26484153_Chip-Seq_NCI-H1993_Human2.00146959
22EZH2_22144423_ChIP-Seq_EOC_Human1.94882131
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.92026002
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.90841555
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90727735
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90099011
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86883113
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72602377
29CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.70795312
30SOX2_20726797_ChIP-Seq_SW620_Human1.70735055
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70633952
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.68449044
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68083936
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.65251302
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65020929
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.60172085
37TP53_18474530_ChIP-ChIP_U2OS_Human1.59053194
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55511613
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54574588
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51085443
41IGF1R_20145208_ChIP-Seq_DFB_Human1.49064335
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48780644
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48487998
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.48408850
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46510677
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44905843
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44704322
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44704322
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44481221
50BRD4_25478319_ChIP-Seq_HGPS_Human1.44044613
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42143920
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41845480
53* TBX20_22328084_ChIP-Seq_HEART_Mouse1.38021983
54* TBX20_22080862_ChIP-Seq_HEART_Mouse1.38021983
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.36916321
56* SMAD4_21799915_ChIP-Seq_A2780_Human1.35700611
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.33350586
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33021176
59RXR_22108803_ChIP-Seq_LS180_Human1.32618649
60BCAT_22108803_ChIP-Seq_LS180_Human1.32497065
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32328147
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30224150
63SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28443821
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28443821
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23298401
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22920585
67TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18508696
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18237932
69JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18086879
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17981964
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16380342
72* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15229871
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14803208
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14143177
75TCF4_18268006_ChIP-ChIP_LS174T_Human1.10376833
76GBX2_23144817_ChIP-Seq_PC3_Human1.09110736
77PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09032809
78SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08524047
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07101683
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05774049
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05672303
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05520982
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04593786
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04347436
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03947333
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03916675
87MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03882333
88* KDM2B_26808549_Chip-Seq_REH_Human1.03462753
89AR_21572438_ChIP-Seq_LNCaP_Human1.03203949
90TP63_23658742_ChIP-Seq_EP156T_Human1.02932511
91EZH2_27304074_Chip-Seq_ESCs_Mouse1.02703354
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.02677368
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.02567715
94TP53_16413492_ChIP-PET_HCT116_Human1.02206774
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02178363
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01948618
97LXR_22158963_ChIP-Seq_LIVER_Mouse1.01407617
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01221535
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00998139
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99809305
101* P300_19829295_ChIP-Seq_ESCs_Human0.99031806
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97144208
103YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96913909
104* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96250896
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96025444
106* AR_25329375_ChIP-Seq_VCAP_Human0.95567483
107VDR_24787735_ChIP-Seq_THP-1_Human0.95347215
108GATA1_22025678_ChIP-Seq_K562_Human0.95208637
109CDX2_20551321_ChIP-Seq_CACO-2_Human0.94884457
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94860008
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94647695
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94355243
113RNF2_27304074_Chip-Seq_ESCs_Mouse0.94222638
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94152456
115EZH2_27294783_Chip-Seq_NPCs_Mouse0.92615303
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.92412418
117AHR_22903824_ChIP-Seq_MCF-7_Human0.91930785
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90580480
119FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90551356
120NANOG_18555785_Chip-Seq_ESCs_Mouse0.89293214
121* ELK3_25401928_ChIP-Seq_HUVEC_Human0.89137327
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88661917
123* SA1_22415368_ChIP-Seq_MEFs_Mouse0.88379843
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87610036
125JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87309856
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86771612
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.84642324
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82508622
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82386988
130RXR_22158963_ChIP-Seq_LIVER_Mouse0.80886295
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79961422
132NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.79430545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.77132064
2MP0003705_abnormal_hypodermis_morpholog4.26222953
3MP0010368_abnormal_lymphatic_system4.18058653
4MP0003279_aneurysm3.71258999
5MP0001879_abnormal_lymphatic_vessel3.65867993
6MP0005275_abnormal_skin_tensile3.58590494
7MP0004272_abnormal_basement_membrane3.43014643
8MP0005503_abnormal_tendon_morphology3.07654686
9MP0001958_emphysema2.76795180
10MP0009780_abnormal_chondrocyte_physiolo2.61862699
11MP0003950_abnormal_plasma_membrane2.60692650
12MP0009384_cardiac_valve_regurgitation2.57958064
13MP0006054_spinal_hemorrhage2.47855039
14MP0005167_abnormal_blood-brain_barrier2.40668119
15MP0005623_abnormal_meninges_morphology2.23205037
16MP0003191_abnormal_cellular_cholesterol2.10800647
17MP0003828_pulmonary_edema2.08903014
18MP0005171_absent_coat_pigmentation2.05276124
19MP0005360_urolithiasis2.01894039
20MP0010234_abnormal_vibrissa_follicle1.86374990
21MP0002295_abnormal_pulmonary_circulatio1.81184139
22MP0001542_abnormal_bone_strength1.78497290
23MP0003300_gastrointestinal_ulcer1.75636457
24MP0004084_abnormal_cardiac_muscle1.70646448
25MP0010386_abnormal_urinary_bladder1.68627985
26MP0003045_fibrosis1.62215243
27MP0010352_gastrointestinal_tract_polyps1.61065724
28MP0005257_abnormal_intraocular_pressure1.59971872
29MP0006138_congestive_heart_failure1.59765055
30MP0000639_abnormal_adrenal_gland1.56542830
31MP0000767_abnormal_smooth_muscle1.55971017
32MP0005084_abnormal_gallbladder_morpholo1.53233188
33MP0000013_abnormal_adipose_tissue1.53033619
34MP0005165_increased_susceptibility_to1.52480631
35MP0000372_irregular_coat_pigmentation1.49188491
36MP0001661_extended_life_span1.47081989
37MP0005248_abnormal_Harderian_gland1.45787073
38MP0003091_abnormal_cell_migration1.44927367
39MP0002332_abnormal_exercise_endurance1.44895895
40MP0005023_abnormal_wound_healing1.42089275
41MP0000465_gastrointestinal_hemorrhage1.40895928
42MP0005595_abnormal_vascular_smooth1.36841850
43MP0004147_increased_porphyrin_level1.35668892
44MP0003724_increased_susceptibility_to1.32666886
45MP0002972_abnormal_cardiac_muscle1.27059606
46MP0000343_altered_response_to1.26296421
47MP0005330_cardiomyopathy1.25678796
48MP0002168_other_aberrant_phenotype1.25451260
49MP0003566_abnormal_cell_adhesion1.23806109
50MP0002896_abnormal_bone_mineralization1.22440130
51MP0000537_abnormal_urethra_morphology1.22383380
52MP0002138_abnormal_hepatobiliary_system1.19960534
53MP0009278_abnormal_bone_marrow1.18773278
54MP0002166_altered_tumor_susceptibility1.18694798
55MP0004883_abnormal_blood_vessel1.18065453
56MP0004215_abnormal_myocardial_fiber1.17089773
57MP0005620_abnormal_muscle_contractility1.13795707
58MP0002108_abnormal_muscle_morphology1.12817076
59MP0005164_abnormal_response_to1.12434792
60MP0005508_abnormal_skeleton_morphology1.09872367
61MP0008775_abnormal_heart_ventricle1.07929697
62MP0002060_abnormal_skin_morphology1.06941017
63MP0005385_cardiovascular_system_phenoty1.06929686
64MP0001544_abnormal_cardiovascular_syste1.06929686
65MP0000462_abnormal_digestive_system1.06053031
66MP0002128_abnormal_blood_circulation1.05815495
67MP0008004_abnormal_stomach_pH1.05372231
68MP0003252_abnormal_bile_duct1.05338989
69MP0004085_abnormal_heartbeat1.05146807
70MP0004484_altered_response_of1.03221453
71MP0004134_abnormal_chest_morphology1.03019768
72MP0003075_altered_response_to1.02156578
73MP0003941_abnormal_skin_development1.01121761
74MP0004036_abnormal_muscle_relaxation1.01114156
75MP0003878_abnormal_ear_physiology1.00716669
76MP0005377_hearing/vestibular/ear_phenot1.00716669
77MP0001986_abnormal_taste_sensitivity1.00128355
78MP0002928_abnormal_bile_duct0.99041547
79MP0010630_abnormal_cardiac_muscle0.95865509
80MP0001915_intracranial_hemorrhage0.95795405
81MP0001614_abnormal_blood_vessel0.94036846
82MP0001853_heart_inflammation0.92829456
83MP0004145_abnormal_muscle_electrophysio0.92569830
84MP0003137_abnormal_impulse_conducting0.92276729
85MP0000750_abnormal_muscle_regeneration0.90948238
86MP0000751_myopathy0.89642053
87MP0002933_joint_inflammation0.89144219
88MP0003385_abnormal_body_wall0.87885666
89MP0000249_abnormal_blood_vessel0.87880046
90MP0005670_abnormal_white_adipose0.86445233
91MP0009250_abnormal_appendicular_skeleto0.86383215
92MP0000230_abnormal_systemic_arterial0.85265705
93MP0000534_abnormal_ureter_morphology0.85205992
94MP0002249_abnormal_larynx_morphology0.83765674
95MP0000163_abnormal_cartilage_morphology0.82833328
96MP0000538_abnormal_urinary_bladder0.82075726
97MP0005369_muscle_phenotype0.81741246
98MP0002925_abnormal_cardiovascular_devel0.81078506
99MP0001984_abnormal_olfaction0.80170468
100MP0001299_abnormal_eye_distance/0.79677704
101MP0003283_abnormal_digestive_organ0.78687528
102MP0002837_dystrophic_cardiac_calcinosis0.78242553
103MP0002133_abnormal_respiratory_system0.78053479
104MP0005388_respiratory_system_phenotype0.78053479
105MP0005408_hypopigmentation0.76733070
106MP0004087_abnormal_muscle_fiber0.76453138
107MP0005666_abnormal_adipose_tissue0.76249858
108MP0002282_abnormal_trachea_morphology0.75830737
109MP0003011_delayed_dark_adaptation0.74803233
110MP0004130_abnormal_muscle_cell0.74651763
111MP0002006_tumorigenesis0.74053665
112MP0010030_abnormal_orbit_morphology0.73235943
113MP0005367_renal/urinary_system_phenotyp0.72976486
114MP0000516_abnormal_urinary_system0.72976486
115MP0009697_abnormal_copulation0.72224898
116MP0001533_abnormal_skeleton_physiology0.70963220
117MP0002254_reproductive_system_inflammat0.70913749
118MP0004233_abnormal_muscle_weight0.70427407
119MP0005390_skeleton_phenotype0.70297498
120MP0002998_abnormal_bone_remodeling0.69743390
121MP0000604_amyloidosis0.65571417
122MP0002909_abnormal_adrenal_gland0.65569016
123MP0002115_abnormal_skeleton_extremities0.65416593
124MP0001243_abnormal_dermal_layer0.63436216
125MP0002106_abnormal_muscle_physiology0.62866110
126MP0002127_abnormal_cardiovascular_syste0.62611487
127MP0003329_amyloid_beta_deposits0.62485517
128MP0000049_abnormal_middle_ear0.62439409
129MP0000266_abnormal_heart_morphology0.62183970
130MP0005193_abnormal_anterior_eye0.60510721
131MP0005253_abnormal_eye_physiology0.59340382

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.04683721
2Premature rupture of membranes (HP:0001788)5.58172018
3Aortic aneurysm (HP:0004942)5.36220568
4Aortic dissection (HP:0002647)4.79260389
5Vascular tortuosity (HP:0004948)4.39743334
6Broad metatarsal (HP:0001783)4.22593248
7Complement deficiency (HP:0004431)4.00036088
8Decreased circulating renin level (HP:0003351)3.84685517
9Arterial tortuosity (HP:0005116)3.80212884
10Cerebral aneurysm (HP:0004944)3.73868019
11Soft skin (HP:0000977)3.63591550
12Abnormality of complement system (HP:0005339)3.35355810
13Shallow orbits (HP:0000586)3.34066194
14Bladder diverticulum (HP:0000015)3.30122241
15Atrophic scars (HP:0001075)3.23370198
16Dilatation of the ascending aorta (HP:0005111)3.21469832
17Hematochezia (HP:0002573)3.08424309
18Asymmetric septal hypertrophy (HP:0001670)3.05474529
19Camptodactyly of toe (HP:0001836)3.03829923
20Short hallux (HP:0010109)3.01546281
21Wormian bones (HP:0002645)2.98525225
22Hip contracture (HP:0003273)2.93004017
23Lymphangioma (HP:0100764)2.90996746
24Peritonitis (HP:0002586)2.89159388
25Bone cyst (HP:0012062)2.87430410
26Limited hip movement (HP:0008800)2.86391939
27Cervical subluxation (HP:0003308)2.82645244
28Aneurysm (HP:0002617)2.81335670
29Aplasia/Hypoplasia of the hallux (HP:0008362)2.78470371
30Pulmonary artery stenosis (HP:0004415)2.78216142
31Spinal rigidity (HP:0003306)2.74527228
32Glucose intolerance (HP:0000833)2.73468248
33Fragile skin (HP:0001030)2.73160100
34Facial diplegia (HP:0001349)2.70609659
35Abnormality of dentin (HP:0010299)2.68199532
36Reduced subcutaneous adipose tissue (HP:0003758)2.66096071
37Ankle contracture (HP:0006466)2.63929985
38Neonatal short-limb short stature (HP:0008921)2.61320912
39Facial shape deformation (HP:0011334)2.58162469
40Potter facies (HP:0002009)2.58162469
41Follicular hyperkeratosis (HP:0007502)2.58116133
42Genu recurvatum (HP:0002816)2.56120379
43Venous insufficiency (HP:0005293)2.54279527
44Increased connective tissue (HP:0009025)2.53307307
45Overgrowth (HP:0001548)2.53245903
46Right ventricular cardiomyopathy (HP:0011663)2.49390111
47Hyperaldosteronism (HP:0000859)2.49047109
48Primary atrial arrhythmia (HP:0001692)2.48578842
49Chondrocalcinosis (HP:0000934)2.47044673
50Neck muscle weakness (HP:0000467)2.46444267
51Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.45303993
52Systemic lupus erythematosus (HP:0002725)2.42698152
53Biconcave vertebral bodies (HP:0004586)2.40487127
54Hypoplasia of the uterus (HP:0000013)2.40430651
55Flexion contracture of toe (HP:0005830)2.39657889
56Joint contractures involving the joints of the feet (HP:0100492)2.39657889
57Blue sclerae (HP:0000592)2.34086910
58Supraventricular arrhythmia (HP:0005115)2.34037592
59Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.33140743
60Supraventricular tachycardia (HP:0004755)2.32916696
61Joint laxity (HP:0001388)2.32597967
62Venous abnormality (HP:0002624)2.32130663
63Ventricular tachycardia (HP:0004756)2.31785734
64Abnormality of Sharpey fibers (HP:0100685)2.31321173
65Syncope (HP:0001279)2.31134715
66Mitral valve prolapse (HP:0001634)2.30966987
67Asymmetry of the thorax (HP:0001555)2.30055172
68Hemiplegia (HP:0002301)2.29464043
69Broad ribs (HP:0000885)2.26850487
70Narrow nasal bridge (HP:0000446)2.25285898
71Abnormality of binocular vision (HP:0011514)2.25152459
72Diplopia (HP:0000651)2.25152459
73Lipoatrophy (HP:0100578)2.24626058
74Vitreoretinal degeneration (HP:0000655)2.24160388
75Renal salt wasting (HP:0000127)2.20076121
76Mitral stenosis (HP:0001718)2.19966936
77Acanthosis nigricans (HP:0000956)2.19681083
78Patent foramen ovale (HP:0001655)2.19008361
79Aortic valve stenosis (HP:0001650)2.18878505
80Cardiovascular calcification (HP:0011915)2.18598373
81Bowel diverticulosis (HP:0005222)2.18531977
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.16519763
83Osteolytic defects of the hand bones (HP:0009699)2.16519763
84Type 1 muscle fiber predominance (HP:0003803)2.16340714
85Joint stiffness (HP:0001387)2.15837835
86Hyperextensible skin (HP:0000974)2.14794909
87Enlarged penis (HP:0000040)2.13141131
88Spontaneous hematomas (HP:0007420)2.12414887
89Mucosal telangiectasiae (HP:0100579)2.10733956
90Infantile muscular hypotonia (HP:0008947)2.07702668
91Buphthalmos (HP:0000557)2.05983303
92Knee flexion contracture (HP:0006380)2.05532585
93Hypoplasia of the iris (HP:0007676)2.03606461
94Coronal craniosynostosis (HP:0004440)2.03073756
95Abnormality of the calf musculature (HP:0001430)2.02752395
96Striae distensae (HP:0001065)2.02021766
97Growth hormone excess (HP:0000845)2.00609868
98Vertebral compression fractures (HP:0002953)2.00600843
99Round ear (HP:0100830)1.98685374
100Wrist flexion contracture (HP:0001239)1.98273345
101Mitral regurgitation (HP:0001653)1.97693680
102Abnormal glucose tolerance (HP:0001952)1.97542555
103Aplasia involving bones of the extremities (HP:0009825)1.97302169
104Aplasia involving bones of the upper limbs (HP:0009823)1.97302169
105Aplasia of the phalanges of the hand (HP:0009802)1.97302169
106Slender build (HP:0001533)1.96642071
107Abnormality of the frontal sinuses (HP:0002687)1.95451761
108Muscle fiber splitting (HP:0003555)1.94823665
109Visceral angiomatosis (HP:0100761)1.93522804
110Absent frontal sinuses (HP:0002688)1.92658343
111Abnormality of secondary sexual hair (HP:0009888)1.92174516
112Abnormality of the axillary hair (HP:0100134)1.92174516
113Abnormality of the ischium (HP:0003174)1.92000983
114Polycythemia (HP:0001901)1.91201230
115Exercise-induced muscle cramps (HP:0003710)1.90852836
116Congenital sensorineural hearing impairment (HP:0008527)1.90600833
117Mesangial abnormality (HP:0001966)1.90549914
118Sudden death (HP:0001699)1.90486161
119Esophageal varix (HP:0002040)1.90223266
120Hypoglycemic coma (HP:0001325)1.87064412
121Recurrent gram-negative bacterial infections (HP:0005420)1.86269382
122Keratoconus (HP:0000563)1.86182315
123Increased corneal curvature (HP:0100692)1.86182315
124Abnormality of the anterior chamber (HP:0000593)1.85610644
125Mildly elevated creatine phosphokinase (HP:0008180)1.85391594
126Abnormality of skeletal muscle fiber size (HP:0012084)1.84856285
127Ovoid vertebral bodies (HP:0003300)1.84710489
128Abnormal delivery (HP:0001787)1.84389693
129Glomerulonephritis (HP:0000099)1.84029128
130Persistence of primary teeth (HP:0006335)1.83683926
131Nephritis (HP:0000123)1.83579880
132Conjunctival hamartoma (HP:0100780)1.83218469
133Ectopia lentis (HP:0001083)1.83128008
134Hyporeflexia of lower limbs (HP:0002600)1.82234726
135Cavernous hemangioma (HP:0001048)1.81763616
136Ulnar bowing (HP:0003031)1.80633948
137Hemangiomatosis (HP:0007461)1.80360270
138Increased variability in muscle fiber diameter (HP:0003557)1.79219354
139Morphological abnormality of the middle ear (HP:0008609)1.78452291
140Bell-shaped thorax (HP:0001591)1.77793487
141Tarsal synostosis (HP:0008368)1.77573330
142Radial bowing (HP:0002986)1.77192973
143Spondylolisthesis (HP:0003302)1.76801861
144Aortic regurgitation (HP:0001659)1.76741035
145Atrial fibrillation (HP:0005110)1.76499124
146Exostoses (HP:0100777)1.75084350
147Hemiparesis (HP:0001269)1.75071085
148Prominent supraorbital ridges (HP:0000336)1.73332688
149Nonimmune hydrops fetalis (HP:0001790)1.72519665
150Wide anterior fontanel (HP:0000260)1.70831546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.47051688
2TIE14.85914632
3DDR23.39978018
4MYLK3.23067652
5TTN3.01649810
6FGFR22.74322790
7PIK3CA2.74307813
8KDR2.69461075
9TGFBR22.45540926
10CAMK1D2.07759214
11PDGFRA2.06315564
12EPHB21.89958707
13LMTK21.89384496
14FER1.84583924
15PTK61.83332456
16PDK21.79908397
17ACVR1B1.76823756
18MAPKAPK31.65266388
19FLT31.62072401
20TGFBR11.58026772
21JAK31.54527502
22NEK91.48672413
23ERN11.46436805
24FGFR31.44452839
25TRPM71.44046027
26RIPK11.42471945
27GRK11.39255572
28STK391.39217761
29CAMK1G1.38327377
30NLK1.36245755
31TRIB31.35957758
32PTK2B1.34559478
33LATS11.34124472
34PAK31.33879064
35PAK21.33757898
36EEF2K1.27853657
37DMPK1.26699215
38CAMKK21.21154695
39PKN21.18609935
40SCYL21.16676426
41MST41.16478949
42ADRBK11.15102524
43NUAK11.14144900
44ROCK11.14006108
45PIK3CG1.13913299
46BCKDK1.10010877
47GRK71.09610079
48LATS21.09514813
49GRK51.05429973
50EPHA31.03681786
51SIK11.03166549
52PDK31.01487223
53PDK41.01487223
54MAPK121.00432812
55PTK20.99014850
56IRAK10.97414528
57WNK40.97027344
58ITK0.95271311
59PRKG20.88483828
60PRKCH0.88439651
61BLK0.86697318
62PRKD30.86305459
63PRKD20.82511818
64STK38L0.81397322
65NEK60.80837234
66INSRR0.78175930
67LRRK20.77132723
68CSF1R0.76091312
69PINK10.74726316
70PRKAA20.74287155
71PHKG20.69800185
72PHKG10.69800185
73AKT30.68171821
74LIMK10.67783841
75MOS0.67157695
76MAP2K10.66408303
77PRKD10.64757096
78PRKCE0.62284405
79TESK10.60921959
80MAP3K60.60745997
81ERBB30.59887987
82IGF1R0.59614425
83MAP3K70.59159271
84OBSCN0.59086635
85INSR0.56402410
86EPHB10.54434776
87FGFR10.52949625
88SRC0.51345218
89MELK0.50118528
90PAK40.49833962
91ROCK20.48440651
92FGFR40.48440328
93RET0.48346888
94PDGFRB0.48195010
95JAK20.47856925
96MAP3K50.46260301
97GSK3A0.45996508
98MAPK40.45206395
99BCR0.44294694
100RPS6KA20.42949080
101STK380.42786076
102OXSR10.41632768
103SGK20.38864642
104MAPK70.38638589
105DYRK1B0.38555045
106BTK0.38210232
107MET0.37119489
108TYK20.36280333
109CAMK10.35058851
110MAP4K10.33168300
111SGK4940.32936735
112SGK2230.32936735
113AKT20.32700958
114CSNK1G10.32631006
115PRKG10.29877643
116MAP2K30.29707938
117JAK10.29675302
118STK30.29266548
119PDK10.29143495
120RPS6KC10.28177402
121KSR20.27839690
122CDC42BPA0.27551559
123STK100.26617836
124CSK0.26432043
125CAMKK10.24859832
126CAMK40.23907086
127ILK0.23833220
128WNK10.22078515
129ABL10.21651652
130KIT0.20601430
131CAMK2G0.19084448
132TEC0.18675411
133NTRK10.17201964

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.67645280
2ECM-receptor interaction_Homo sapiens_hsa045123.18176788
3* Focal adhesion_Homo sapiens_hsa045102.75784614
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.67578167
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.52982293
6Steroid hormone biosynthesis_Homo sapiens_hsa001402.45396360
7Steroid biosynthesis_Homo sapiens_hsa001002.28218684
8Propanoate metabolism_Homo sapiens_hsa006402.25382885
9Vitamin B6 metabolism_Homo sapiens_hsa007502.16720210
10Dilated cardiomyopathy_Homo sapiens_hsa054142.05066030
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.03817049
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00467765
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.91660662
14Protein digestion and absorption_Homo sapiens_hsa049741.91459380
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.83548468
16Adherens junction_Homo sapiens_hsa045201.74654002
17Malaria_Homo sapiens_hsa051441.70981427
18Fatty acid degradation_Homo sapiens_hsa000711.69243397
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.66810255
20Proteoglycans in cancer_Homo sapiens_hsa052051.64569980
21Caffeine metabolism_Homo sapiens_hsa002321.58797787
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58355701
23Fatty acid metabolism_Homo sapiens_hsa012121.55452699
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48064122
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45865688
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45504998
27Tyrosine metabolism_Homo sapiens_hsa003501.38568479
28Mineral absorption_Homo sapiens_hsa049781.37571134
29TGF-beta signaling pathway_Homo sapiens_hsa043501.37316190
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35408913
31PPAR signaling pathway_Homo sapiens_hsa033201.30961828
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28389846
33Small cell lung cancer_Homo sapiens_hsa052221.27087415
34Tight junction_Homo sapiens_hsa045301.26257582
35Bile secretion_Homo sapiens_hsa049761.23529066
36* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.22675140
37Fatty acid biosynthesis_Homo sapiens_hsa000611.19393970
38ABC transporters_Homo sapiens_hsa020101.14289676
39Renin-angiotensin system_Homo sapiens_hsa046141.12043698
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11840512
41Staphylococcus aureus infection_Homo sapiens_hsa051501.09227162
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08030056
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04672503
44* Rap1 signaling pathway_Homo sapiens_hsa040151.03890273
45Gastric acid secretion_Homo sapiens_hsa049711.02708250
46Platelet activation_Homo sapiens_hsa046111.02323095
47Amoebiasis_Homo sapiens_hsa051461.02194952
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01328226
49Other glycan degradation_Homo sapiens_hsa005111.00744595
50Tryptophan metabolism_Homo sapiens_hsa003800.94936007
51Viral myocarditis_Homo sapiens_hsa054160.94788987
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94685504
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94401383
54Cardiac muscle contraction_Homo sapiens_hsa042600.91804097
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.90988944
56Arachidonic acid metabolism_Homo sapiens_hsa005900.90386440
57Thyroid hormone synthesis_Homo sapiens_hsa049180.89896691
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88471025
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87754455
60Linoleic acid metabolism_Homo sapiens_hsa005910.86883738
61Vitamin digestion and absorption_Homo sapiens_hsa049770.84955250
62HIF-1 signaling pathway_Homo sapiens_hsa040660.83743254
63Insulin resistance_Homo sapiens_hsa049310.82526491
64Axon guidance_Homo sapiens_hsa043600.82326749
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79440724
66* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78434964
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77663934
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76161745
69Circadian rhythm_Homo sapiens_hsa047100.75545943
70Dorso-ventral axis formation_Homo sapiens_hsa043200.72704868
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72529484
72Hippo signaling pathway_Homo sapiens_hsa043900.71318268
73Prion diseases_Homo sapiens_hsa050200.70120599
74Renin secretion_Homo sapiens_hsa049240.69499374
75Bladder cancer_Homo sapiens_hsa052190.67931517
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67224859
77Complement and coagulation cascades_Homo sapiens_hsa046100.66943575
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65702545
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65268946
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64775406
81Carbon metabolism_Homo sapiens_hsa012000.62943805
82Hedgehog signaling pathway_Homo sapiens_hsa043400.62696004
83Pyruvate metabolism_Homo sapiens_hsa006200.62287836
84Arginine biosynthesis_Homo sapiens_hsa002200.61984321
85Peroxisome_Homo sapiens_hsa041460.61954419
86MicroRNAs in cancer_Homo sapiens_hsa052060.61104081
87Retinol metabolism_Homo sapiens_hsa008300.59002738
88Starch and sucrose metabolism_Homo sapiens_hsa005000.58965423
89Histidine metabolism_Homo sapiens_hsa003400.58860171
90Pathways in cancer_Homo sapiens_hsa052000.58389741
91* Melanoma_Homo sapiens_hsa052180.58128378
92Pancreatic secretion_Homo sapiens_hsa049720.57973792
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.56652187
94Ovarian steroidogenesis_Homo sapiens_hsa049130.55017525
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54654889
96Fatty acid elongation_Homo sapiens_hsa000620.54201343
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53225967
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52919594
99Notch signaling pathway_Homo sapiens_hsa043300.52620135
100Pertussis_Homo sapiens_hsa051330.52112376
101Prolactin signaling pathway_Homo sapiens_hsa049170.52048164
102Glycerolipid metabolism_Homo sapiens_hsa005610.51889502
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50837668
104Basal cell carcinoma_Homo sapiens_hsa052170.50702367
105Calcium signaling pathway_Homo sapiens_hsa040200.50535811
106Chemical carcinogenesis_Homo sapiens_hsa052040.50171836
107Melanogenesis_Homo sapiens_hsa049160.49738453
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49491447
109* Ras signaling pathway_Homo sapiens_hsa040140.49305429
110Ether lipid metabolism_Homo sapiens_hsa005650.49178638
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49167639
112Butanoate metabolism_Homo sapiens_hsa006500.46828956
113Fat digestion and absorption_Homo sapiens_hsa049750.44713659
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.44669801
115Lysine degradation_Homo sapiens_hsa003100.44587868
116cAMP signaling pathway_Homo sapiens_hsa040240.44024682
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43842899
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43768887
119Toxoplasmosis_Homo sapiens_hsa051450.43554445
120Renal cell carcinoma_Homo sapiens_hsa052110.43093116
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.42085792
122TNF signaling pathway_Homo sapiens_hsa046680.41802850
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41524566
124AMPK signaling pathway_Homo sapiens_hsa041520.40993095
125Glioma_Homo sapiens_hsa052140.39621529
126* Prostate cancer_Homo sapiens_hsa052150.39530858
127* Gap junction_Homo sapiens_hsa045400.38922352
128Glutathione metabolism_Homo sapiens_hsa004800.38886019
129Sulfur metabolism_Homo sapiens_hsa009200.38533790
130* Phospholipase D signaling pathway_Homo sapiens_hsa040720.37669821
131Salmonella infection_Homo sapiens_hsa051320.36990889
132Inositol phosphate metabolism_Homo sapiens_hsa005620.36528212
133Pentose phosphate pathway_Homo sapiens_hsa000300.36493414
134Salivary secretion_Homo sapiens_hsa049700.35855443
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35428041
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33193675
137Glucagon signaling pathway_Homo sapiens_hsa049220.33121572
138Endocytosis_Homo sapiens_hsa041440.33008210

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