PDGFRL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)8.50010408
2bone trabecula formation (GO:0060346)7.69482941
3keratan sulfate catabolic process (GO:0042340)7.61528002
4collagen fibril organization (GO:0030199)7.12131465
5dermatan sulfate biosynthetic process (GO:0030208)6.31825293
6extracellular fibril organization (GO:0043206)6.05438333
7dermatan sulfate metabolic process (GO:0030205)5.84789487
8peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.73886426
9cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.28715392
10sequestering of extracellular ligand from receptor (GO:0035581)5.24822309
11regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.22101560
12fibril organization (GO:0097435)5.09353970
13protein retention in ER lumen (GO:0006621)5.08346916
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.91571829
15collagen catabolic process (GO:0030574)4.81678491
16collagen metabolic process (GO:0032963)4.79274064
17chondrocyte proliferation (GO:0035988)4.72019943
18chondroitin sulfate biosynthetic process (GO:0030206)4.65678816
19multicellular organismal macromolecule metabolic process (GO:0044259)4.46165538
20mesenchymal-epithelial cell signaling (GO:0060638)4.42512181
21multicellular organismal catabolic process (GO:0044243)4.40616661
22Golgi transport vesicle coating (GO:0048200)4.31601271
23COPI coating of Golgi vesicle (GO:0048205)4.31601271
24multicellular organismal metabolic process (GO:0044236)4.22862141
25response to gravity (GO:0009629)4.19879793
26endodermal cell differentiation (GO:0035987)4.18259502
27pattern specification involved in kidney development (GO:0061004)4.07015713
28chondrocyte development (GO:0002063)4.06019628
29extracellular matrix disassembly (GO:0022617)4.05918043
30metanephric mesenchyme development (GO:0072075)4.03171697
31skin morphogenesis (GO:0043589)4.02877369
32cartilage condensation (GO:0001502)3.87104547
33cell aggregation (GO:0098743)3.87104547
34chondroitin sulfate catabolic process (GO:0030207)3.84699720
35mesenchyme morphogenesis (GO:0072132)3.84506528
36peptidyl-proline hydroxylation (GO:0019511)3.83337896
37extracellular regulation of signal transduction (GO:1900115)3.80120708
38extracellular negative regulation of signal transduction (GO:1900116)3.80120708
39kidney mesenchyme development (GO:0072074)3.79125721
40trivalent inorganic anion homeostasis (GO:0072506)3.69708455
41phosphate ion homeostasis (GO:0055062)3.69708455
42extracellular matrix organization (GO:0030198)3.66300042
43extracellular structure organization (GO:0043062)3.64950592
44positive regulation of gastrulation (GO:2000543)3.63409600
45outer ear morphogenesis (GO:0042473)3.56135772
46endocardial cushion morphogenesis (GO:0003203)3.55841083
47protein trimerization (GO:0070206)3.45998074
48positive regulation of osteoblast proliferation (GO:0033690)3.44970649
49blood vessel maturation (GO:0001955)3.36979188
50endothelial cell morphogenesis (GO:0001886)3.34908677
51retina vasculature morphogenesis in camera-type eye (GO:0061299)3.30897515
52keratan sulfate biosynthetic process (GO:0018146)3.30426218
53middle ear morphogenesis (GO:0042474)3.29351385
54smooth muscle tissue development (GO:0048745)3.27598150
55otic vesicle formation (GO:0030916)3.25472415
56notochord development (GO:0030903)3.24966354
57somite development (GO:0061053)3.24813047
58negative regulation of complement activation (GO:0045916)3.24104642
59extracellular matrix assembly (GO:0085029)3.22087195
60glycosaminoglycan catabolic process (GO:0006027)3.21443377
61positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.20667878
62trabecula formation (GO:0060343)3.18092601
63glomerular basement membrane development (GO:0032836)3.15790042
64lymphangiogenesis (GO:0001946)3.14996227
65negative regulation of biomineral tissue development (GO:0070168)3.13307871
66protein hydroxylation (GO:0018126)3.11708208
67regulation of extracellular matrix disassembly (GO:0010715)3.09337443
68nucleotide-sugar biosynthetic process (GO:0009226)3.08945942
69regulation of integrin-mediated signaling pathway (GO:2001044)3.06757359
70glycosaminoglycan biosynthetic process (GO:0006024)3.06559282
71glomerulus development (GO:0032835)3.06033021
72aminoglycan biosynthetic process (GO:0006023)3.03618034
73tooth mineralization (GO:0034505)3.03444485
74aminoglycan catabolic process (GO:0006026)3.00878050
75cartilage development (GO:0051216)3.00863643
76positive regulation of cartilage development (GO:0061036)2.99541544
77establishment of protein localization to mitochondrial membrane (GO:0090151)2.98478421
78negative regulation of chondrocyte differentiation (GO:0032331)2.98141831
79membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97231996
80positive regulation of extracellular matrix organization (GO:1903055)2.96912063
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96244973
82cellular response to vitamin D (GO:0071305)2.95308972
83positive regulation of fatty acid oxidation (GO:0046321)2.94791779
84keratan sulfate metabolic process (GO:0042339)2.92965141
85negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.92058673
86venous blood vessel morphogenesis (GO:0048845)2.90333764
87COPII vesicle coating (GO:0048208)2.89749221
88vasculature development (GO:0001944)2.87640192
89positive regulation of heart rate (GO:0010460)2.86683152
90cellular response to vitamin (GO:0071295)2.86491563
91positive regulation of epithelial to mesenchymal transition (GO:0010718)2.86112119
92sulfur compound catabolic process (GO:0044273)2.84538250
93negative regulation of cartilage development (GO:0061037)2.82565606
94ossification (GO:0001503)2.82338883
95embryonic skeletal joint morphogenesis (GO:0060272)2.82038000
96regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.81996085
97chondroitin sulfate metabolic process (GO:0030204)2.81097502
98substrate-dependent cell migration (GO:0006929)2.79184222
99negative regulation of gluconeogenesis (GO:0045721)2.78356795
100face morphogenesis (GO:0060325)2.77712430
101regulation of biomineral tissue development (GO:0070167)2.76337008
102positive regulation of fatty acid beta-oxidation (GO:0032000)2.74910057
103skeletal system development (GO:0001501)2.74868111
104neuron fate determination (GO:0048664)2.72500186
105camera-type eye morphogenesis (GO:0048593)2.71819980
106cochlea morphogenesis (GO:0090103)2.71722634
107atrioventricular valve morphogenesis (GO:0003181)2.71511104
108cell proliferation involved in kidney development (GO:0072111)2.70368386
109positive regulation of chondrocyte differentiation (GO:0032332)2.70329997
110prostate gland growth (GO:0060736)2.69481133
111nephron epithelium morphogenesis (GO:0072088)2.68659083
112nephron tubule morphogenesis (GO:0072078)2.68659083
113mesonephros development (GO:0001823)2.67834770
114regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.67481489
115cyclic nucleotide catabolic process (GO:0009214)2.64584906
116gamma-aminobutyric acid transport (GO:0015812)2.64036141
117positive regulation of stem cell differentiation (GO:2000738)2.62414683
118behavioral response to nicotine (GO:0035095)2.61762031
119glycine transport (GO:0015816)2.61159146
120ganglion development (GO:0061548)2.59999498
121cAMP catabolic process (GO:0006198)2.58910936
122negative regulation of fatty acid transport (GO:2000192)2.58361822
123regulation of chondrocyte differentiation (GO:0032330)2.57823974
124cell proliferation involved in metanephros development (GO:0072203)2.57693812
125homocysteine metabolic process (GO:0050667)2.57365503
126artery smooth muscle contraction (GO:0014824)2.55341970
127dendritic spine morphogenesis (GO:0060997)2.53811357
128regulation of acrosome reaction (GO:0060046)2.52376476
129cell migration involved in heart development (GO:0060973)2.52018172
130negative regulation of vascular permeability (GO:0043116)2.48784691
131branching involved in salivary gland morphogenesis (GO:0060445)2.48477294
132renal tubule morphogenesis (GO:0061333)2.46642507
133skeletal muscle organ development (GO:0060538)2.38842635
134ATP synthesis coupled proton transport (GO:0015986)2.38368230
135energy coupled proton transport, down electrochemical gradient (GO:0015985)2.38368230
136cardiac right ventricle morphogenesis (GO:0003215)2.36844761
137organ induction (GO:0001759)2.36147553
138paraxial mesoderm development (GO:0048339)2.35419321
139tonic smooth muscle contraction (GO:0014820)2.33704245
140norepinephrine metabolic process (GO:0042415)2.33113126
141outflow tract morphogenesis (GO:0003151)2.32346796
142adrenergic receptor signaling pathway (GO:0071875)2.31672266
143response to redox state (GO:0051775)2.31061473
144negative regulation of heart growth (GO:0061117)2.28380325
145negative regulation of cardiac muscle tissue growth (GO:0055022)2.28380325
146positive regulation of metanephros development (GO:0072216)2.28171011
147establishment of planar polarity (GO:0001736)2.28099080
148establishment of tissue polarity (GO:0007164)2.28099080
149toxin metabolic process (GO:0009404)2.27223565
150regulation of gastrulation (GO:0010470)2.26117183
151embryonic heart tube development (GO:0035050)2.25197420
152lung secretory cell differentiation (GO:0061140)2.24241077
153cAMP metabolic process (GO:0046058)2.23519283
154regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.22696612
155regulation of organ formation (GO:0003156)2.21146957
156radial glial cell differentiation (GO:0060019)2.20223091
157regulation of cardiac muscle hypertrophy (GO:0010611)2.19796882
158positive regulation of heart contraction (GO:0045823)2.18977469
159relaxation of smooth muscle (GO:0044557)2.18579051
160cardiac ventricle morphogenesis (GO:0003208)2.17592408
161mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.16442705
162negative regulation of systemic arterial blood pressure (GO:0003085)2.15914022
163positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.15636634
164cardiac left ventricle morphogenesis (GO:0003214)2.15057871
165respiratory electron transport chain (GO:0022904)2.14940192
166regulation of cardiac muscle cell differentiation (GO:2000725)2.13875862
167relaxation of cardiac muscle (GO:0055119)2.13485396
168protein localization to cell surface (GO:0034394)2.13441373
169electron transport chain (GO:0022900)2.13420555
170diaphragm development (GO:0060539)2.12679736
171aorta morphogenesis (GO:0035909)2.12068992
172regulation of muscle hypertrophy (GO:0014743)2.10420224
173negative regulation of cardiac muscle hypertrophy (GO:0010614)2.10151112
174vasodilation (GO:0042311)2.10059838
175positive regulation of embryonic development (GO:0040019)2.09456421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.98344333
2EZH2_22144423_ChIP-Seq_EOC_Human4.89763202
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.68188540
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.65521805
5RARG_19884340_ChIP-ChIP_MEFs_Mouse4.26806145
6TP63_17297297_ChIP-ChIP_HaCaT_Human4.07714772
7SMAD_19615063_ChIP-ChIP_OVARY_Human3.28638489
8CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.97423109
9* CJUN_26792858_Chip-Seq_BT549_Human2.84392940
10ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.72581621
11TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.62838624
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.62670618
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.42000215
14* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.23608238
15TP53_18474530_ChIP-ChIP_U2OS_Human2.15801729
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.08477300
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04758968
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04122368
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.03139420
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.01419481
21AR_21572438_ChIP-Seq_LNCaP_Human1.97729152
22NRF2_20460467_ChIP-Seq_MEFs_Mouse1.93725758
23NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.93725758
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93031350
25BRD4_25478319_ChIP-Seq_HGPS_Human1.88471905
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87865681
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80195089
28VDR_22108803_ChIP-Seq_LS180_Human1.77548171
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77525172
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76772791
31GATA1_22025678_ChIP-Seq_K562_Human1.74846657
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67875673
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66400358
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64465087
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63422508
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.62617100
37CLOCK_20551151_ChIP-Seq_293T_Human1.61674778
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60874390
39GBX2_23144817_ChIP-Seq_PC3_Human1.60483464
40SOX2_20726797_ChIP-Seq_SW620_Human1.57344733
41JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55527977
42JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53203791
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49779238
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49750816
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49750816
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49750816
47RNF2_27304074_Chip-Seq_NSC_Mouse1.47942912
48BCAT_22108803_ChIP-Seq_LS180_Human1.46893320
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.45184399
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42841133
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42699295
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42693731
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.42340406
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40046460
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40014418
56TAF15_26573619_Chip-Seq_HEK293_Human1.38326943
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37635912
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37635912
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35073235
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34808585
61SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34588010
62FUS_26573619_Chip-Seq_HEK293_Human1.32230224
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30017921
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29353631
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.27407920
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26498283
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.26271043
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25233549
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.23849941
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21285269
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20729620
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.19308508
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.19043520
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.19043201
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18711384
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18197026
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17899590
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17214686
79AR_25329375_ChIP-Seq_VCAP_Human1.16763915
80* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15307709
81ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14507890
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13971391
83SMC1_22415368_ChIP-Seq_MEFs_Mouse1.12789422
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11692958
85LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11090048
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10809647
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08858833
88SA1_22415368_ChIP-Seq_MEFs_Mouse1.08346310
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08006506
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06661559
91MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06619814
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06358469
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.05973768
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05876773
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.05486457
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05111247
97PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04346217
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04148733
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02500138
100NANOG_19829295_ChIP-Seq_ESCs_Human1.02046202
101SOX2_19829295_ChIP-Seq_ESCs_Human1.02046202
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.01635860
103TP53_16413492_ChIP-PET_HCT116_Human1.01615626
104* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01348365
105AHR_22903824_ChIP-Seq_MCF-7_Human1.01313788
106NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01255183
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00705088
108LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99319216
109RUNX2_22187159_ChIP-Seq_PCA_Human0.99305671
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98670754
111EWS_26573619_Chip-Seq_HEK293_Human0.98320632
112EZH2_27294783_Chip-Seq_ESCs_Mouse0.97662772
113HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96849228
114* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96572066
115POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96354131
116EZH2_27294783_Chip-Seq_NPCs_Mouse0.96090830
117TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95803525
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94835815
119CBP_20019798_ChIP-Seq_JUKART_Human0.94835815
120TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93974698
121SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93554160
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93554160
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.93473910
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93433581
125NFI_21473784_ChIP-Seq_ESCs_Mouse0.93134960
126SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92974170
127NANOG_18555785_Chip-Seq_ESCs_Mouse0.92561741
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92500640
129* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92452292
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92082532
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91896299
132MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91870425
133* KDM2B_26808549_Chip-Seq_REH_Human0.91606902
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91443815
135TCF4_23295773_ChIP-Seq_U87_Human0.90282758
136POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90215900
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89877499
138* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89679836
139ESR2_21235772_ChIP-Seq_MCF-7_Human0.89611665
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89289378
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89093620
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85752072
143SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.85628700
144GF1B_26923725_Chip-Seq_HPCs_Mouse0.84080149
145PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.83271854
146SMAD4_21799915_ChIP-Seq_A2780_Human0.83113425
147TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82872005
148TP53_23651856_ChIP-Seq_MEFs_Mouse0.82195800
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81650040
150TP63_23658742_ChIP-Seq_EP156T_Human0.80801903
151P300_19829295_ChIP-Seq_ESCs_Human0.80678711
152PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.80610792
153* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.80161130
154CRX_20693478_ChIP-Seq_RETINA_Mouse0.79130101
155VDR_24787735_ChIP-Seq_THP-1_Human0.79090630
156PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78696999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.77440401
2MP0005503_abnormal_tendon_morphology8.52775249
3MP0005275_abnormal_skin_tensile5.93708510
4MP0003279_aneurysm3.06970417
5MP0005508_abnormal_skeleton_morphology3.04796722
6MP0001958_emphysema2.99179531
7MP0005257_abnormal_intraocular_pressure2.78708603
8MP0006054_spinal_hemorrhage2.66042164
9MP0003283_abnormal_digestive_organ2.49043669
10MP0002108_abnormal_muscle_morphology2.45392470
11MP0001542_abnormal_bone_strength2.39488907
12MP0004134_abnormal_chest_morphology2.25459282
13MP0003705_abnormal_hypodermis_morpholog2.18748440
14MP0004272_abnormal_basement_membrane2.15820396
15MP0009250_abnormal_appendicular_skeleto2.13370885
16MP0002933_joint_inflammation2.08750116
17MP0002060_abnormal_skin_morphology2.05407979
18MP0002837_dystrophic_cardiac_calcinosis1.92736878
19MP0005390_skeleton_phenotype1.91087071
20MP0000163_abnormal_cartilage_morphology1.86072913
21MP0009384_cardiac_valve_regurgitation1.70601372
22MP0010368_abnormal_lymphatic_system1.66897318
23MP0002115_abnormal_skeleton_extremities1.66374296
24MP0002896_abnormal_bone_mineralization1.63173229
25MP0000049_abnormal_middle_ear1.58154923
26MP0002295_abnormal_pulmonary_circulatio1.57616721
27MP0003566_abnormal_cell_adhesion1.56523221
28MP0002638_abnormal_pupillary_reflex1.49867902
29MP0004215_abnormal_myocardial_fiber1.49807756
30MP0002113_abnormal_skeleton_development1.47747624
31MP0004142_abnormal_muscle_tone1.47043040
32MP0002876_abnormal_thyroid_physiology1.44679446
33MP0010030_abnormal_orbit_morphology1.39529813
34MP0002282_abnormal_trachea_morphology1.38222229
35MP0009379_abnormal_foot_pigmentation1.37853037
36MP0002932_abnormal_joint_morphology1.36356839
37MP0003880_abnormal_central_pattern1.35313108
38MP0001533_abnormal_skeleton_physiology1.34364748
39MP0002249_abnormal_larynx_morphology1.33515027
40MP0002998_abnormal_bone_remodeling1.32156185
41MP0003136_yellow_coat_color1.32110432
42MP0001299_abnormal_eye_distance/1.31960485
43MP0005623_abnormal_meninges_morphology1.29624090
44MP0003950_abnormal_plasma_membrane1.28041622
45MP0006072_abnormal_retinal_apoptosis1.24204739
46MP0003795_abnormal_bone_structure1.22206423
47MP0002877_abnormal_melanocyte_morpholog1.21636851
48MP0009780_abnormal_chondrocyte_physiolo1.20186127
49MP0005023_abnormal_wound_healing1.19960101
50MP0001243_abnormal_dermal_layer1.17594070
51MP0008877_abnormal_DNA_methylation1.15075372
52MP0002116_abnormal_craniofacial_bone1.14771593
53MP0003385_abnormal_body_wall1.14408001
54MP0005171_absent_coat_pigmentation1.14400419
55MP0002109_abnormal_limb_morphology1.13296649
56MP0009046_muscle_twitch1.12675622
57MP0000013_abnormal_adipose_tissue1.09636600
58MP0000230_abnormal_systemic_arterial1.08331670
59MP0002160_abnormal_reproductive_system1.08076895
60MP0000428_abnormal_craniofacial_morphol1.06050043
61MP0005084_abnormal_gallbladder_morpholo1.05796697
62MP0010386_abnormal_urinary_bladder1.02169096
63MP0002272_abnormal_nervous_system1.01494351
64MP0000372_irregular_coat_pigmentation1.00473205
65MP0005620_abnormal_muscle_contractility0.99996003
66MP0000762_abnormal_tongue_morphology0.99515348
67MP0003879_abnormal_hair_cell0.98343469
68MP0000026_abnormal_inner_ear0.96965447
69MP0002233_abnormal_nose_morphology0.96861053
70MP0000432_abnormal_head_morphology0.96445699
71MP0000767_abnormal_smooth_muscle0.96185622
72MP0005551_abnormal_eye_electrophysiolog0.92970286
73MP0003755_abnormal_palate_morphology0.92953557
74MP0005253_abnormal_eye_physiology0.90995034
75MP0005423_abnormal_somatic_nervous0.90978176
76MP0000751_myopathy0.90829737
77MP0000733_abnormal_muscle_development0.89606855
78MP0001986_abnormal_taste_sensitivity0.88905919
79MP0006292_abnormal_olfactory_placode0.88749124
80MP0004145_abnormal_muscle_electrophysio0.88215050
81MP0001485_abnormal_pinna_reflex0.88174692
82MP0001324_abnormal_eye_pigmentation0.87862251
83MP0004885_abnormal_endolymph0.87553555
84MP0005220_abnormal_exocrine_pancreas0.86391131
85MP0002277_abnormal_respiratory_mucosa0.86088288
86MP0003115_abnormal_respiratory_system0.85828204
87MP0004510_myositis0.84966504
88MP0005409_darkened_coat_color0.84577643
89MP0002938_white_spotting0.84492459
90MP0005379_endocrine/exocrine_gland_phen0.83743030
91MP0002089_abnormal_postnatal_growth/wei0.82597803
92MP0003938_abnormal_ear_development0.82356391
93MP0001944_abnormal_pancreas_morphology0.82119289
94MP0003942_abnormal_urinary_system0.81512610
95MP0000534_abnormal_ureter_morphology0.81206744
96MP0003935_abnormal_craniofacial_develop0.80355999
97MP0009745_abnormal_behavioral_response0.79460321
98MP0003123_paternal_imprinting0.77809431
99MP0000631_abnormal_neuroendocrine_gland0.77046911
100MP0003941_abnormal_skin_development0.76953725
101MP0002111_abnormal_tail_morphology0.76920136
102MP0004133_heterotaxia0.76279473
103MP0002972_abnormal_cardiac_muscle0.76219959
104MP0004085_abnormal_heartbeat0.76134262
105MP0005389_reproductive_system_phenotype0.75462782
106MP0001270_distended_abdomen0.74045810
107MP0000613_abnormal_salivary_gland0.73974420
108MP0001486_abnormal_startle_reflex0.73597499
109MP0000749_muscle_degeneration0.73584922
110MP0003091_abnormal_cell_migration0.73010036
111MP0002168_other_aberrant_phenotype0.71349544
112MP0001879_abnormal_lymphatic_vessel0.71023159
113MP0001177_atelectasis0.70201995
114MP0003448_altered_tumor_morphology0.69786868
115MP0003137_abnormal_impulse_conducting0.69564926
116MP0005595_abnormal_vascular_smooth0.68845117
117MP0001175_abnormal_lung_morphology0.68575253
118MP0004484_altered_response_of0.68137594
119MP0002114_abnormal_axial_skeleton0.68032600
120MP0003937_abnormal_limbs/digits/tail_de0.67927637
121MP0005369_muscle_phenotype0.67922665
122MP0000566_synostosis0.67832647
123MP0001502_abnormal_circadian_rhythm0.67426824
124MP0003195_calcinosis0.66759972
125MP0002928_abnormal_bile_duct0.66179433
126MP0002177_abnormal_outer_ear0.65353807
127MP0000678_abnormal_parathyroid_gland0.64969842
128MP0005164_abnormal_response_to0.64448893
129MP0001756_abnormal_urination0.64352955
130MP0000343_altered_response_to0.63581759
131MP0005646_abnormal_pituitary_gland0.61818239
132MP0002138_abnormal_hepatobiliary_system0.61197523
133MP0000681_abnormal_thyroid_gland0.60470554
134MP0003122_maternal_imprinting0.58838935
135MP0003646_muscle_fatigue0.58406140
136MP0005377_hearing/vestibular/ear_phenot0.57289653
137MP0003878_abnormal_ear_physiology0.57289653
138MP0000516_abnormal_urinary_system0.55648428
139MP0005367_renal/urinary_system_phenotyp0.55648428
140MP0002128_abnormal_blood_circulation0.54673418
141MP0005193_abnormal_anterior_eye0.53925192
142MP0002163_abnormal_gland_morphology0.50826690
143MP0000003_abnormal_adipose_tissue0.50477706
144MP0001346_abnormal_lacrimal_gland0.50173005
145MP0005197_abnormal_uvea_morphology0.50023201
146MP0002133_abnormal_respiratory_system0.49927909
147MP0005388_respiratory_system_phenotype0.49927909
148MP0001348_abnormal_lacrimal_gland0.49016061
149MP0001614_abnormal_blood_vessel0.45821454
150MP0003724_increased_susceptibility_to0.45443104

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.38734429
2Premature rupture of membranes (HP:0001788)6.86044886
3Neonatal short-limb short stature (HP:0008921)5.75184845
4Broad metatarsal (HP:0001783)4.45309519
5Cervical subluxation (HP:0003308)4.42562434
6Ankle contracture (HP:0006466)4.32373938
7Soft skin (HP:0000977)4.23620596
8Abnormality of dentin (HP:0010299)4.15425319
9Vertebral compression fractures (HP:0002953)4.12110636
10Epiphyseal dysplasia (HP:0002656)4.07955576
11Follicular hyperkeratosis (HP:0007502)4.06042449
12Mild short stature (HP:0003502)3.92787138
13Metaphyseal dysplasia (HP:0100255)3.91991665
14Bladder diverticulum (HP:0000015)3.90075691
15Biconcave vertebral bodies (HP:0004586)3.88846958
16Aortic dissection (HP:0002647)3.82698992
17Atrophic scars (HP:0001075)3.59874042
18Irregular epiphyses (HP:0010582)3.56909293
19Abnormality of the frontal sinuses (HP:0002687)3.49414925
20Small epiphyses (HP:0010585)3.35399564
21Wormian bones (HP:0002645)3.24458946
22Blue sclerae (HP:0000592)3.18622312
23Osteoarthritis (HP:0002758)3.15943750
24Shallow orbits (HP:0000586)3.14956411
25Spinal rigidity (HP:0003306)3.07416936
26Ulnar claw (HP:0001178)3.03345304
27Beaking of vertebral bodies (HP:0004568)3.02694265
28Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.02570971
29Cupped ribs (HP:0000887)3.01657453
30Flat capital femoral epiphysis (HP:0003370)2.97193804
31Abnormality of the acetabulum (HP:0003170)2.94871877
32Hypoplastic ischia (HP:0003175)2.91032543
33Infantile muscular hypotonia (HP:0008947)2.90481880
34Vitreoretinal degeneration (HP:0000655)2.86920526
35Abnormal delivery (HP:0001787)2.85247055
36Genu recurvatum (HP:0002816)2.85079411
37Arthropathy (HP:0003040)2.81876327
38Type 1 muscle fiber predominance (HP:0003803)2.80428528
39Platyspondyly (HP:0000926)2.67813998
40Partial duplication of the phalanx of hand (HP:0009999)2.66867588
41Breech presentation (HP:0001623)2.65977827
42Fragile skin (HP:0001030)2.64942946
43Pigmentary retinal degeneration (HP:0001146)2.61367529
44Limited hip movement (HP:0008800)2.60027608
45Aortic aneurysm (HP:0004942)2.59647591
46Fibular hypoplasia (HP:0003038)2.59004923
47Dilatation of the ascending aorta (HP:0005111)2.58287510
48Wrist flexion contracture (HP:0001239)2.55803474
49Joint laxity (HP:0001388)2.53398468
50Coxa vara (HP:0002812)2.52847427
51Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.51787598
52Venous insufficiency (HP:0005293)2.51696895
53Vascular tortuosity (HP:0004948)2.50766855
54Peritonitis (HP:0002586)2.50577807
55Abnormality of the phalanges of the 2nd finger (HP:0009541)2.48585030
56Abnormality of the ischium (HP:0003174)2.47757761
57Delayed epiphyseal ossification (HP:0002663)2.44879895
58Keratoconus (HP:0000563)2.43801133
59Increased corneal curvature (HP:0100692)2.43801133
60Pulmonary artery stenosis (HP:0004415)2.42891705
61Hip contracture (HP:0003273)2.42263275
62Anomalous pulmonary venous return (HP:0010772)2.41828554
63Mesomelia (HP:0003027)2.41506376
64Abnormal tarsal ossification (HP:0008369)2.39693838
65Genu varum (HP:0002970)2.37711366
66Abnormality of the pulmonary veins (HP:0011718)2.36993846
67Abnormal drinking behavior (HP:0030082)2.36522993
68Polydipsia (HP:0001959)2.36522993
69Hyperextensible skin (HP:0000974)2.36107319
70Spondylolisthesis (HP:0003302)2.33781106
71Congenital, generalized hypertrichosis (HP:0004540)2.31465873
72Spinal cord compression (HP:0002176)2.31091401
73Thoracolumbar scoliosis (HP:0002944)2.29376184
74Broad long bones (HP:0005622)2.27717066
75Mitral valve prolapse (HP:0001634)2.27715099
76Broad ribs (HP:0000885)2.25146284
77Aplasia/Hypoplasia of the fibula (HP:0006492)2.23661502
78Slender build (HP:0001533)2.22933967
79Muscle hypertrophy of the lower extremities (HP:0008968)2.20380656
80Irregular vertebral endplates (HP:0003301)2.17562632
81Action tremor (HP:0002345)2.16503786
82Short hallux (HP:0010109)2.15999297
83Mesangial abnormality (HP:0001966)2.15154892
84Atrial fibrillation (HP:0005110)2.14901258
85Abnormality of the vertebral endplates (HP:0005106)2.12024904
86Bowel diverticulosis (HP:0005222)2.12009066
87Joint stiffness (HP:0001387)2.10252329
88Choroideremia (HP:0001139)2.08080767
89Increased connective tissue (HP:0009025)2.07243117
90Cerebral aneurysm (HP:0004944)2.07069058
91Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.06912741
92Abnormality of femoral epiphyses (HP:0006499)2.06912741
93Bell-shaped thorax (HP:0001591)2.06892848
94Ovoid vertebral bodies (HP:0003300)2.04986051
95Aortic regurgitation (HP:0001659)2.04939517
96Septo-optic dysplasia (HP:0100842)2.04599780
97Decreased skull ossification (HP:0004331)2.03108075
98Mildly elevated creatine phosphokinase (HP:0008180)2.03034414
99Ectopia lentis (HP:0001083)2.03019641
100Flat acetabular roof (HP:0003180)2.02163163
101Morphological abnormality of the middle ear (HP:0008609)2.02159954
102Mitral regurgitation (HP:0001653)2.02142498
103Primary atrial arrhythmia (HP:0001692)2.00924573
104Metaphyseal cupping (HP:0003021)2.00531677
105Wide anterior fontanel (HP:0000260)2.00156769
106Calf muscle hypertrophy (HP:0008981)1.99679265
107Tibial bowing (HP:0002982)1.99459299
108Lymphangioma (HP:0100764)1.97355619
109Striae distensae (HP:0001065)1.97157864
110Flattened epiphyses (HP:0003071)1.96686012
111Venous abnormality (HP:0002624)1.96062259
112Hypoplasia of the odontoid process (HP:0003311)1.95947000
113Aplasia/Hypoplasia of the hallux (HP:0008362)1.95714666
114Polyuria (HP:0000103)1.95245593
115Supraventricular arrhythmia (HP:0005115)1.94746492
116Femoral bowing (HP:0002980)1.94358001
117Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94261258
118Maternal diabetes (HP:0009800)1.93060268
119Abnormality of calcium-phosphate metabolism (HP:0100530)1.92896153
120Overgrowth (HP:0001548)1.91634327
121Osteopenia (HP:0000938)1.91547794
122Bone cyst (HP:0012062)1.91205520
123Abnormality of the epiphysis of the femoral head (HP:0010574)1.90834648
124Aortic valve stenosis (HP:0001650)1.90587786
125Abnormality of carpal bone ossification (HP:0006257)1.90446276
126Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.89888829
127Elbow flexion contracture (HP:0002987)1.89574903
128Metaphyseal irregularity (HP:0003025)1.89427548
129Supraventricular tachycardia (HP:0004755)1.89333720
130Nonimmune hydrops fetalis (HP:0001790)1.89216498
131Limited elbow extension (HP:0001377)1.88858642
132Abnormality of the femoral head (HP:0003368)1.88430953
133Lumbar hyperlordosis (HP:0002938)1.84798279
134Abnormal foot bone ossification (HP:0010675)1.84319565
135Absent frontal sinuses (HP:0002688)1.83350060
136Thin bony cortex (HP:0002753)1.83228028
137Broad phalanx (HP:0006009)1.82694522
138Arterial tortuosity (HP:0005116)1.80527460
139Syncope (HP:0001279)1.79893464
140Short nail (HP:0001799)1.79522630
141Aplasia involving bones of the upper limbs (HP:0009823)1.78291735
142Aplasia of the phalanges of the hand (HP:0009802)1.78291735
143Aplasia involving bones of the extremities (HP:0009825)1.78291735
144Hyporeflexia of lower limbs (HP:0002600)1.76731206
145Short tibia (HP:0005736)1.76167179
146Muscle fiber splitting (HP:0003555)1.75445987
147Prominent supraorbital ridges (HP:0000336)1.75273721
148Parakeratosis (HP:0001036)1.74824528
149Cardiovascular calcification (HP:0011915)1.74084214
150Abnormality of the calf musculature (HP:0001430)1.73598899
151Preaxial foot polydactyly (HP:0001841)1.73241917
152Patent foramen ovale (HP:0001655)1.70764644
153Abnormal urine output (HP:0012590)1.69189522
154Enlarged penis (HP:0000040)1.67821142
155Hyperlipoproteinemia (HP:0010980)1.67643727
156Pancreatic fibrosis (HP:0100732)1.66737340
157Median cleft lip (HP:0000161)1.64538509
158Renal Fanconi syndrome (HP:0001994)1.64503903
159Partial duplication of thumb phalanx (HP:0009944)1.64462252
160Tubular atrophy (HP:0000092)1.62758991
161Decreased circulating renin level (HP:0003351)1.59515975
162Aplasia/Hypoplasia of the tibia (HP:0005772)1.59422256
163Hypoplastic left heart (HP:0004383)1.58777221
164Large for gestational age (HP:0001520)1.58422622
165Abnormality of renal resorption (HP:0011038)1.57820387
166Abnormality of renal excretion (HP:0011036)1.57138553
167Abnormality of the 2nd finger (HP:0004100)1.55931796
168Absent phalangeal crease (HP:0006109)1.55863137

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK15.24275425
2DDR24.90065787
3INSRR4.62377524
4STK38L3.73737972
5ERBB33.24032840
6PNCK3.13884750
7LATS13.00234860
8PIM22.75261861
9TNIK2.68238408
10MAPK152.49502023
11STK242.33748482
12TRIB32.26139248
13ZAK2.24104532
14EPHA32.23183273
15LATS22.16379397
16PRKD21.99177425
17GRK11.91994756
18BMPR1B1.91782854
19PHKG11.88220610
20PHKG21.88220610
21PDGFRA1.87126651
22ADRBK21.77164380
23NEK91.76677194
24TGFBR21.74781317
25STK31.72403341
26OBSCN1.69904798
27NTRK21.68572264
28CASK1.54267896
29BMPR21.52761451
30NEK21.52131730
31ABL21.50651680
32PDK21.48357302
33MAP4K21.44679883
34TRPM71.42189583
35STK391.41081917
36MAP3K121.40267353
37ERN11.36701044
38TAOK31.36412426
39DMPK1.35433954
40TSSK61.32525333
41PLK21.32488925
42EPHB21.31015300
43NUAK11.27035620
44RPS6KA41.23491495
45GRK71.19898454
46RIPK11.16306382
47PRKCG1.14986960
48MAP2K71.14146257
49MAPKAPK31.12987079
50ADRBK11.12150564
51FRK1.10186836
52IRAK31.10116134
53BLK1.10026617
54CAMK2D1.09065731
55BMX1.08561331
56FER1.08228660
57MARK11.07284996
58MAP3K31.06220824
59PRKCH1.05325632
60PRKD31.04179036
61PRKCE1.03105780
62TAOK11.01913086
63PIK3CG1.01297088
64TLK11.01147188
65CAMK2A1.00376124
66NLK0.94292063
67PDGFRB0.94281569
68PINK10.93530285
69SIK10.91670507
70PRKG10.91339126
71LMTK20.90564097
72DYRK30.90349909
73CSNK1G10.90024322
74STK160.87543724
75TYRO30.86366135
76SGK20.85469436
77JAK30.84628792
78WNK40.82380880
79ROCK10.82296189
80TIE10.81689607
81WNK30.80101675
82IRAK10.79219357
83PKN10.78727761
84TTN0.77024752
85OXSR10.76999731
86ARAF0.76771239
87MET0.74638184
88BRAF0.72504230
89CAMK2G0.72432962
90CAMK10.71972335
91PAK30.68967157
92PAK20.68637389
93MAP3K140.68629861
94MAPK120.68140367
95NME20.67238715
96PIM10.66876409
97LIMK10.66518861
98PLK30.64463907
99PLK40.64144932
100NME10.63945895
101CAMK40.63671971
102CSNK1A10.63275931
103MST1R0.62468120
104PRKCI0.62026917
105CHUK0.61170873
106MST40.59804981
107SGK4940.59460068
108SGK2230.59460068
109NEK60.58745480
110AKT20.57587803
111IKBKB0.57250532
112TESK10.56910936
113MAPKAPK50.55969168
114EPHA20.55937572
115PRPF4B0.55720086
116EIF2AK20.55665600
117PRKACA0.54786113
118TGFBR10.54712206
119MAP3K90.54575773
120FGFR20.54363628
121MUSK0.53588256
122JAK10.53181749
123PRKG20.53071013
124NTRK30.52389608
125IRAK40.50131883
126WNK10.50044777
127MAP3K70.49318954
128CDC42BPA0.48141412
129GSK3A0.47409113
130PTK20.46395980
131VRK10.46395231
132MAP2K20.45958718
133DYRK20.45720965
134ERBB40.45205137
135MAPK40.44608858
136ILK0.44275863
137MOS0.42764122
138IRAK20.42760690
139FGFR30.42602993
140GRK50.42431200
141PASK0.42425452
142MAPK130.41652520
143PTK60.40672533
144CSK0.40647250
145CAMK2B0.38856440
146STK40.38674645
147SGK30.38216154
148SGK10.37992900
149MKNK20.37812858
150PAK40.37147603
151CDK30.35558682
152BCR0.34913700
153FGFR10.34800264
154MTOR0.33797406
155RPS6KA50.31683582
156PIK3CA0.30682978
157MYLK0.30287863
158PBK0.29383101
159TAOK20.29138568
160INSR0.28636143
161MAPK70.27091957
162PTK2B0.26812685
163IGF1R0.26750662
164DYRK1B0.26748123
165PRKD10.26112795
166TEC0.25286132
167HIPK20.24890423
168MAPKAPK20.23930179

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.87366000
2ECM-receptor interaction_Homo sapiens_hsa045124.74535321
3Protein digestion and absorption_Homo sapiens_hsa049743.46081586
4Cardiac muscle contraction_Homo sapiens_hsa042603.07759143
5Oxidative phosphorylation_Homo sapiens_hsa001902.95999232
6Malaria_Homo sapiens_hsa051442.75646933
7Focal adhesion_Homo sapiens_hsa045102.46702282
8Folate biosynthesis_Homo sapiens_hsa007902.38220489
9Parkinsons disease_Homo sapiens_hsa050122.35002906
10Protein export_Homo sapiens_hsa030602.30072591
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.22276259
12TGF-beta signaling pathway_Homo sapiens_hsa043502.13391917
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11249337
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.97221881
15Ribosome_Homo sapiens_hsa030101.96768741
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80333250
17Amoebiasis_Homo sapiens_hsa051461.78852351
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74840537
19Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.74830157
20PI3K-Akt signaling pathway_Homo sapiens_hsa041511.73346256
21Alzheimers disease_Homo sapiens_hsa050101.70527871
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.65398126
23Proteoglycans in cancer_Homo sapiens_hsa052051.59512470
24Huntingtons disease_Homo sapiens_hsa050161.56073168
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.54083989
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.52248992
27Arachidonic acid metabolism_Homo sapiens_hsa005901.49646086
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48403212
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.47203685
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.45821276
31Hedgehog signaling pathway_Homo sapiens_hsa043401.43861271
32Basal cell carcinoma_Homo sapiens_hsa052171.41862655
33Dilated cardiomyopathy_Homo sapiens_hsa054141.37445893
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37080629
35Nicotine addiction_Homo sapiens_hsa050331.36529575
36Melanoma_Homo sapiens_hsa052181.35941250
37Other glycan degradation_Homo sapiens_hsa005111.34353265
38Hippo signaling pathway_Homo sapiens_hsa043901.33835198
39Linoleic acid metabolism_Homo sapiens_hsa005911.33800643
40GABAergic synapse_Homo sapiens_hsa047271.33025526
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32480135
42Renin secretion_Homo sapiens_hsa049241.31581785
43Bladder cancer_Homo sapiens_hsa052191.30395772
44Morphine addiction_Homo sapiens_hsa050321.28391666
45Sulfur relay system_Homo sapiens_hsa041221.26260420
46Dorso-ventral axis formation_Homo sapiens_hsa043201.23993879
47TNF signaling pathway_Homo sapiens_hsa046681.23975036
48Adherens junction_Homo sapiens_hsa045201.21852563
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16989819
50Caffeine metabolism_Homo sapiens_hsa002321.15698495
51Prostate cancer_Homo sapiens_hsa052151.13569342
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08403560
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.05870919
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05401161
55Wnt signaling pathway_Homo sapiens_hsa043101.05137544
56Phototransduction_Homo sapiens_hsa047441.04761018
57Tryptophan metabolism_Homo sapiens_hsa003801.03892347
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03811160
59Small cell lung cancer_Homo sapiens_hsa052221.03192815
60Sphingolipid metabolism_Homo sapiens_hsa006001.03137390
61Ovarian steroidogenesis_Homo sapiens_hsa049131.03099903
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00634037
63Thyroid hormone synthesis_Homo sapiens_hsa049180.98052044
64Sulfur metabolism_Homo sapiens_hsa009200.97475102
65p53 signaling pathway_Homo sapiens_hsa041150.97362147
66MicroRNAs in cancer_Homo sapiens_hsa052060.93587113
67Circadian entrainment_Homo sapiens_hsa047130.92439489
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92438527
69Rheumatoid arthritis_Homo sapiens_hsa053230.90275814
70Phagosome_Homo sapiens_hsa041450.90112195
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89338162
72Vibrio cholerae infection_Homo sapiens_hsa051100.87826065
73Pathways in cancer_Homo sapiens_hsa052000.87431479
74Collecting duct acid secretion_Homo sapiens_hsa049660.87157046
75Arginine and proline metabolism_Homo sapiens_hsa003300.86196910
76Chemical carcinogenesis_Homo sapiens_hsa052040.84868391
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84180492
78cAMP signaling pathway_Homo sapiens_hsa040240.83277795
79Glutamatergic synapse_Homo sapiens_hsa047240.82790949
80ABC transporters_Homo sapiens_hsa020100.82751196
81N-Glycan biosynthesis_Homo sapiens_hsa005100.82498499
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81672460
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.78331836
84Retinol metabolism_Homo sapiens_hsa008300.78267599
85Calcium signaling pathway_Homo sapiens_hsa040200.76142728
86Chronic myeloid leukemia_Homo sapiens_hsa052200.75750127
87Apoptosis_Homo sapiens_hsa042100.74947185
88Leishmaniasis_Homo sapiens_hsa051400.74020400
89Lysosome_Homo sapiens_hsa041420.73922341
90Olfactory transduction_Homo sapiens_hsa047400.71944196
91Taste transduction_Homo sapiens_hsa047420.71792984
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71750788
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70687217
94Salivary secretion_Homo sapiens_hsa049700.69515524
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.69121614
96Toxoplasmosis_Homo sapiens_hsa051450.68648171
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68002461
98Oxytocin signaling pathway_Homo sapiens_hsa049210.67912291
99Melanogenesis_Homo sapiens_hsa049160.67355574
100Amphetamine addiction_Homo sapiens_hsa050310.66566742
101HTLV-I infection_Homo sapiens_hsa051660.66035662
102Propanoate metabolism_Homo sapiens_hsa006400.65896597
103Pancreatic secretion_Homo sapiens_hsa049720.65328356
104Fat digestion and absorption_Homo sapiens_hsa049750.64438765
105Legionellosis_Homo sapiens_hsa051340.63176937
106Steroid biosynthesis_Homo sapiens_hsa001000.63111986
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63002105
108Peroxisome_Homo sapiens_hsa041460.62939473
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62814381
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62316501
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61570261
112Ether lipid metabolism_Homo sapiens_hsa005650.60612674
113Prion diseases_Homo sapiens_hsa050200.60566054
114Pancreatic cancer_Homo sapiens_hsa052120.60560865
115Serotonergic synapse_Homo sapiens_hsa047260.60509944
116Type I diabetes mellitus_Homo sapiens_hsa049400.59625927
117Insulin secretion_Homo sapiens_hsa049110.58937331
118Hepatitis B_Homo sapiens_hsa051610.58668391
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58440786
120Ras signaling pathway_Homo sapiens_hsa040140.58016759
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.56859179
122Fatty acid elongation_Homo sapiens_hsa000620.56393813
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54752555
124PPAR signaling pathway_Homo sapiens_hsa033200.54743220
125FoxO signaling pathway_Homo sapiens_hsa040680.53606332
126Complement and coagulation cascades_Homo sapiens_hsa046100.53056323
127Rap1 signaling pathway_Homo sapiens_hsa040150.52513307
128Tight junction_Homo sapiens_hsa045300.52254353
129Vitamin digestion and absorption_Homo sapiens_hsa049770.51897909
130Circadian rhythm_Homo sapiens_hsa047100.51843817
131beta-Alanine metabolism_Homo sapiens_hsa004100.51625988
132Starch and sucrose metabolism_Homo sapiens_hsa005000.51052093
133Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50810411
134Nitrogen metabolism_Homo sapiens_hsa009100.49978218
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49946078
136Phenylalanine metabolism_Homo sapiens_hsa003600.49896654
137Histidine metabolism_Homo sapiens_hsa003400.48945778
138Axon guidance_Homo sapiens_hsa043600.48515489
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47896507
140HIF-1 signaling pathway_Homo sapiens_hsa040660.46850530
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46681443
142Osteoclast differentiation_Homo sapiens_hsa043800.44426055
143Glioma_Homo sapiens_hsa052140.42090222
144Leukocyte transendothelial migration_Homo sapiens_hsa046700.41961060
145Viral myocarditis_Homo sapiens_hsa054160.40260422
146Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38942581
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38462495
148Platelet activation_Homo sapiens_hsa046110.38348571
149Graft-versus-host disease_Homo sapiens_hsa053320.37942038
150Pertussis_Homo sapiens_hsa051330.37726445
151Cocaine addiction_Homo sapiens_hsa050300.36411185
152Colorectal cancer_Homo sapiens_hsa052100.36294899
153Lysine degradation_Homo sapiens_hsa003100.36268151
154Endometrial cancer_Homo sapiens_hsa052130.35877927
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.35766694
156Glutathione metabolism_Homo sapiens_hsa004800.34036738
157Intestinal immune network for IgA production_Homo sapiens_hsa046720.32767238
158Autoimmune thyroid disease_Homo sapiens_hsa053200.32555727
159Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30879878
160Estrogen signaling pathway_Homo sapiens_hsa049150.30345822
161Mineral absorption_Homo sapiens_hsa049780.28979105
162Galactose metabolism_Homo sapiens_hsa000520.27889846
163SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27074109
164Vascular smooth muscle contraction_Homo sapiens_hsa042700.25697317
165Renin-angiotensin system_Homo sapiens_hsa046140.25506340

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