PDHA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* tricarboxylic acid cycle (GO:0006099)8.22714595
2NADH metabolic process (GO:0006734)7.09367238
3* regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)6.48796161
4carnitine shuttle (GO:0006853)6.24770448
5* regulation of acyl-CoA biosynthetic process (GO:0050812)6.00419157
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.83084532
7sarcomere organization (GO:0045214)5.82984322
8* regulation of cofactor metabolic process (GO:0051193)5.68097349
9* regulation of coenzyme metabolic process (GO:0051196)5.68097349
10fatty acid transmembrane transport (GO:1902001)5.59016376
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.43481627
12cardiac myofibril assembly (GO:0055003)5.39014654
13succinate metabolic process (GO:0006105)5.27706454
14lysine catabolic process (GO:0006554)5.18281183
15lysine metabolic process (GO:0006553)5.18281183
16negative regulation of potassium ion transmembrane transport (GO:1901380)5.13293418
172-oxoglutarate metabolic process (GO:0006103)5.11779305
18oxaloacetate metabolic process (GO:0006107)5.10194024
19muscle filament sliding (GO:0030049)4.97534379
20actin-myosin filament sliding (GO:0033275)4.97534379
21regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.92368223
22plasma membrane repair (GO:0001778)4.86327702
23regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.84021703
24myofibril assembly (GO:0030239)4.71281172
25carnitine transmembrane transport (GO:1902603)4.70686698
26tricarboxylic acid metabolic process (GO:0072350)4.62100038
27amino-acid betaine transport (GO:0015838)4.60277871
28carnitine transport (GO:0015879)4.60277871
29regulation of sequestering of triglyceride (GO:0010889)4.57763259
30cardiac muscle contraction (GO:0060048)4.57628797
31aspartate family amino acid catabolic process (GO:0009068)4.50747172
32* regulation of sulfur metabolic process (GO:0042762)4.49009414
33fatty acid beta-oxidation (GO:0006635)4.44424143
34oxidative phosphorylation (GO:0006119)4.40496742
35regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.38571825
36branched-chain amino acid catabolic process (GO:0009083)4.34051217
37biotin metabolic process (GO:0006768)4.32615207
38regulation of fatty acid oxidation (GO:0046320)4.28275313
39regulation of skeletal muscle contraction (GO:0014819)4.26173327
40regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.19190130
41proteasome assembly (GO:0043248)4.17840081
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.09808116
43ventricular cardiac muscle cell action potential (GO:0086005)4.08180728
44cardiac muscle cell development (GO:0055013)4.08127892
45valine metabolic process (GO:0006573)4.07725689
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.03790002
47branched-chain amino acid metabolic process (GO:0009081)4.03483193
48actin-mediated cell contraction (GO:0070252)4.02168691
49regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.93670081
50regulation of actin filament-based movement (GO:1903115)3.92730123
51regulation of relaxation of muscle (GO:1901077)3.91791726
52regulation of cell communication by electrical coupling (GO:0010649)3.85250481
53formation of translation preinitiation complex (GO:0001731)3.83546645
54sarcoplasmic reticulum calcium ion transport (GO:0070296)3.77863027
55actomyosin structure organization (GO:0031032)3.77370991
56cardiac cell development (GO:0055006)3.76834305
57ribosome assembly (GO:0042255)3.76537496
58regulation of mitochondrial translation (GO:0070129)3.74259032
59striated muscle contraction (GO:0006941)3.73822061
60cardiac muscle hypertrophy (GO:0003300)3.72499058
61respiratory electron transport chain (GO:0022904)3.71589351
62cell communication involved in cardiac conduction (GO:0086065)3.69773802
63fatty acid catabolic process (GO:0009062)3.69185416
64fatty acid oxidation (GO:0019395)3.67426637
65quaternary ammonium group transport (GO:0015697)3.64372587
66electron transport chain (GO:0022900)3.61204938
67DNA strand elongation involved in DNA replication (GO:0006271)3.60364427
68lipid oxidation (GO:0034440)3.59757090
69striated muscle hypertrophy (GO:0014897)3.56911536
70energy coupled proton transport, down electrochemical gradient (GO:0015985)3.54404297
71ATP synthesis coupled proton transport (GO:0015986)3.54404297
72bundle of His cell to Purkinje myocyte communication (GO:0086069)3.53190227
73cell communication by electrical coupling (GO:0010644)3.49185141
74establishment of integrated proviral latency (GO:0075713)3.47957149
75mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.47264029
76DNA strand elongation (GO:0022616)3.43920510
77fatty acid homeostasis (GO:0055089)3.42785950
78regulation of membrane repolarization (GO:0060306)3.40246112
79regulation of sarcomere organization (GO:0060297)3.37789622
80telomere maintenance via semi-conservative replication (GO:0032201)3.36389331
81heart trabecula formation (GO:0060347)3.32710379
82* acetyl-CoA metabolic process (GO:0006084)3.32513046
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31082050
84gluconeogenesis (GO:0006094)3.30951220
85chaperone-mediated protein transport (GO:0072321)3.28632273
86lipid particle organization (GO:0034389)3.27922750
87positive regulation of fatty acid oxidation (GO:0046321)3.27788207
88DNA unwinding involved in DNA replication (GO:0006268)3.27688456
89short-chain fatty acid metabolic process (GO:0046459)3.27375361
90regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23258830
91ribosomal large subunit biogenesis (GO:0042273)3.21506744
92anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.21433441
93CENP-A containing nucleosome assembly (GO:0034080)3.20452850
94establishment of protein localization to mitochondrial membrane (GO:0090151)3.19408245
95cardiac muscle cell action potential involved in contraction (GO:0086002)3.18888446
96chromatin remodeling at centromere (GO:0031055)3.18870041
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18861187
98ribosome biogenesis (GO:0042254)3.18799460
99regulation of striated muscle contraction (GO:0006942)3.18078444
100cardiac muscle tissue morphogenesis (GO:0055008)3.16100197
101DNA replication checkpoint (GO:0000076)3.15669803
102maturation of SSU-rRNA (GO:0030490)3.15359457
103creatine metabolic process (GO:0006600)3.14317256
104cardiac muscle cell action potential (GO:0086001)3.14066135
105protein targeting to mitochondrion (GO:0006626)3.12620181
106cullin deneddylation (GO:0010388)3.12241967
107regulation of the force of heart contraction (GO:0002026)3.12097037
108hexose biosynthetic process (GO:0019319)3.09920837
109synapsis (GO:0007129)3.08592705
110ribonucleoprotein complex biogenesis (GO:0022613)3.08217124
111muscle hypertrophy (GO:0014896)3.08027653
112regulation of translational fidelity (GO:0006450)3.05424771
113carnitine metabolic process (GO:0009437)3.04898308
114negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04206735
115negative regulation of ligase activity (GO:0051352)3.04206735
116aerobic respiration (GO:0009060)3.03917368
117cardiac muscle adaptation (GO:0014887)3.03529696
118cardiac muscle hypertrophy in response to stress (GO:0014898)3.03529696
119muscle hypertrophy in response to stress (GO:0003299)3.03529696
120intracellular lipid transport (GO:0032365)3.02632018
121actin filament-based movement (GO:0030048)3.00427832
122mitotic sister chromatid segregation (GO:0000070)2.98822732
123monocarboxylic acid catabolic process (GO:0072329)2.98112986
124negative regulation of potassium ion transport (GO:0043267)2.95275358
125tRNA aminoacylation for protein translation (GO:0006418)2.93994803
126protein deneddylation (GO:0000338)2.92711540
127cellular ketone body metabolic process (GO:0046950)2.92507648
128ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.92231460
129ribosomal small subunit biogenesis (GO:0042274)2.92128212
130positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.91542235
131protein maturation by protein folding (GO:0022417)2.91268692
132mitotic metaphase plate congression (GO:0007080)2.91186107
133positive regulation of fatty acid beta-oxidation (GO:0032000)2.89215776
134adult heart development (GO:0007512)2.88365958
135protein localization to mitochondrion (GO:0070585)2.88217185
136glycogen catabolic process (GO:0005980)2.88072883
137DNA synthesis involved in DNA repair (GO:0000731)2.86849710
138amino acid activation (GO:0043038)2.86392750
139tRNA aminoacylation (GO:0043039)2.86392750
140ubiquinone biosynthetic process (GO:0006744)2.85375553
141nucleobase-containing small molecule interconversion (GO:0015949)2.84737875
142nuclear pore complex assembly (GO:0051292)2.84032158
143positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82419866
144cellular component biogenesis (GO:0044085)2.81525638
145ribosomal small subunit assembly (GO:0000028)2.80806488
146regulation of cellular amino acid metabolic process (GO:0006521)2.79438698
147establishment of protein localization to mitochondrion (GO:0072655)2.78842794
148ventricular cardiac muscle cell development (GO:0055015)2.78382210
149spliceosomal snRNP assembly (GO:0000387)2.77966642
150histone exchange (GO:0043486)2.77603690
151IMP biosynthetic process (GO:0006188)2.77347929
152DNA replication initiation (GO:0006270)2.76405359
153protein localization to kinetochore (GO:0034501)2.76238934
154mitotic recombination (GO:0006312)2.75458380
155mitochondrial transport (GO:0006839)2.74317849
156telomere maintenance via recombination (GO:0000722)2.72929330
157sister chromatid segregation (GO:0000819)2.71643874
158DNA ligation (GO:0006266)2.70873959
159establishment of viral latency (GO:0019043)2.70628343
160homocysteine metabolic process (GO:0050667)2.70073063
161L-serine metabolic process (GO:0006563)2.69543978
162positive regulation of ligase activity (GO:0051351)2.69378951
163purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.68559443
164purine nucleoside monophosphate biosynthetic process (GO:0009127)2.68559443
165translation (GO:0006412)2.67656475
166regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.67548061
167signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.67518726
168intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.67518726
169signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67422016
170signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67422016
171signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67422016
172non-recombinational repair (GO:0000726)2.67048865
173double-strand break repair via nonhomologous end joining (GO:0006303)2.67048865
174DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.67024090
175IMP metabolic process (GO:0046040)2.66234584
176signal transduction involved in DNA damage checkpoint (GO:0072422)2.64959368
177signal transduction involved in DNA integrity checkpoint (GO:0072401)2.64959368
178nuclear pore organization (GO:0006999)2.64866660
179inner mitochondrial membrane organization (GO:0007007)2.64533620
180ubiquinone metabolic process (GO:0006743)2.64190179
181cellular respiration (GO:0045333)2.63991973
182pseudouridine synthesis (GO:0001522)2.62418921
183regulation of ubiquitin-protein transferase activity (GO:0051438)2.61625518
184ATP biosynthetic process (GO:0006754)2.60980092
185purine nucleobase biosynthetic process (GO:0009113)2.60852912
186rRNA modification (GO:0000154)2.60744622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.80857839
2E2F7_22180533_ChIP-Seq_HELA_Human6.04051644
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse5.64730580
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.31345582
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.82337435
6MYC_18555785_ChIP-Seq_MESCs_Mouse4.19275065
7ZNF263_19887448_ChIP-Seq_K562_Human3.98903526
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.52251895
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.51876336
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.50259777
11CLOCK_20551151_ChIP-Seq_293T_Human3.43095849
12* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.25408663
13EST1_17652178_ChIP-ChIP_JURKAT_Human3.14904406
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04471102
15ETS1_20019798_ChIP-Seq_JURKAT_Human3.00991952
16E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00263609
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.83284691
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.82345677
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80445883
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73772260
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.66273057
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.62016082
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56894883
24TBX20_22328084_ChIP-Seq_HEART_Mouse2.48113195
25TBX20_22080862_ChIP-Seq_HEART_Mouse2.48113195
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.47476757
27DCP1A_22483619_ChIP-Seq_HELA_Human2.45868136
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42862697
29NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.42546536
30XRN2_22483619_ChIP-Seq_HELA_Human2.42217364
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38037368
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.32612870
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32134972
34PPARA_22158963_ChIP-Seq_LIVER_Mouse2.23546326
35RXR_22158963_ChIP-Seq_LIVER_Mouse2.13578578
36ESR1_20079471_ChIP-ChIP_T-47D_Human2.12221721
37GABP_19822575_ChIP-Seq_HepG2_Human2.08107681
38STAT3_1855785_ChIP-Seq_MESCs_Mouse2.05737218
39SRF_21415370_ChIP-Seq_HL-1_Mouse2.05692762
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.02215716
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.01703182
42TTF2_22483619_ChIP-Seq_HELA_Human1.99185937
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98759262
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97938835
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96569455
46FOXP3_21729870_ChIP-Seq_TREG_Human1.94991228
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.90513844
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89414054
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87980054
50MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.87353263
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86684528
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85595733
53ELK1_19687146_ChIP-ChIP_HELA_Human1.84126500
54GATA4_21415370_ChIP-Seq_HL-1_Mouse1.83527371
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80369798
56VDR_23849224_ChIP-Seq_CD4+_Human1.80302774
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.77013915
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75764336
59LXR_22158963_ChIP-Seq_LIVER_Mouse1.67069174
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.66655614
61* E2F1_21310950_ChIP-Seq_MCF-7_Human1.66174246
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62954980
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61409420
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54821300
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52746628
66ATF3_27146783_Chip-Seq_COLON_Human1.52506323
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52048657
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50452520
69PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.50153327
70NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.49750692
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49430995
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47278978
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.47242022
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46955418
75* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45993648
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44463089
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43235759
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42819050
79KDM5A_27292631_Chip-Seq_BREAST_Human1.41918152
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40311745
81AR_21909140_ChIP-Seq_LNCAP_Human1.35383948
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31717348
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28769218
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28461453
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24182631
86TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.19338236
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16256065
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14975223
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14625728
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14119621
91CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13031618
92NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12752073
93* GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.12282179
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11943999
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11858658
96MYC_18940864_ChIP-ChIP_HL60_Human1.11469577
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10096904
98SOX17_20123909_ChIP-Seq_XEN_Mouse1.10093600
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08731491
100RACK7_27058665_Chip-Seq_MCF-7_Human1.06001590
101ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04880187
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04369108
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03935233
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03512442
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03338057
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02084189
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02036103
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00962874
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00920926
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98174674
111ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96831396
112TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96411806
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96072109
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95681155
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95459070
116TFEB_21752829_ChIP-Seq_HELA_Human0.95288190
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95205556
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.94174124
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93833410
120KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93420245
121RARB_27405468_Chip-Seq_BRAIN_Mouse0.91709508
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91628767
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.91059014
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90517088
125* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90283025
126* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90269670
127SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90171778
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90171450
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88967593
130OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88807767
131* NANOG_21062744_ChIP-ChIP_HESCs_Human0.87440989
132P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87098602
133* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87062618
134* CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86466427
135MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85201464
136NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85035892
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84950470
138SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84303494
139CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83448786
140TRIM28_21343339_ChIP-Seq_HEK293_Human0.83226785
141NANOG_16153702_ChIP-ChIP_HESCs_Human0.81626842
142SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81588911
143THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81559396
144ZNF274_21170338_ChIP-Seq_K562_Hela0.81254283
145ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80995277
146TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80888832
147TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79824018
148P68_20966046_ChIP-Seq_HELA_Human0.79415937
149RUNX1_27514584_Chip-Seq_MCF-7_Human0.79330070
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78553429
151DNAJC2_21179169_ChIP-ChIP_NT2_Human0.77780798
152FOXH1_21741376_ChIP-Seq_ESCs_Human0.77270796
153ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77136387
154THAP11_20581084_ChIP-Seq_MESCs_Mouse0.76848381
155E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76778634
156* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.76338018
157TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76306363
158GATA1_22025678_ChIP-Seq_K562_Human0.75122476
159CREB1_26743006_Chip-Seq_LNCaP_Human0.73443596
160EOMES_21245162_ChIP-Seq_HESCs_Human0.73397196
161CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.73294384
162CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.73234170
163CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73221910
164HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73123888
165TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.72064712
166CTCF_18555785_ChIP-Seq_MESCs_Mouse0.71858631
167GATA3_24758297_ChIP-Seq_MCF-7_Human0.71326897
168SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71230544
169* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.70856073
170* SOX2_21211035_ChIP-Seq_LN229_Gbm0.70684501
171FOXA2_19822575_ChIP-Seq_HepG2_Human0.69961799
172TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.69853369

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.91695597
2MP0003646_muscle_fatigue5.20157725
3MP0004084_abnormal_cardiac_muscle4.63335280
4MP0000751_myopathy4.40518115
5MP0004215_abnormal_myocardial_fiber3.96255724
6MP0004130_abnormal_muscle_cell3.60171566
7MP0008058_abnormal_DNA_repair3.57404922
8MP0004036_abnormal_muscle_relaxation3.56607019
9MP0003693_abnormal_embryo_hatching3.52089536
10MP0010094_abnormal_chromosome_stability3.36941433
11MP0005330_cardiomyopathy3.32574225
12MP0000749_muscle_degeneration3.28644428
13MP0004957_abnormal_blastocyst_morpholog3.26863059
14MP0003111_abnormal_nucleus_morphology2.94501381
15* MP0004087_abnormal_muscle_fiber2.70491861
16MP0000750_abnormal_muscle_regeneration2.57469789
17MP0008932_abnormal_embryonic_tissue2.53905954
18MP0008775_abnormal_heart_ventricle2.49083320
19* MP0002972_abnormal_cardiac_muscle2.48473442
20MP0003077_abnormal_cell_cycle2.45981342
21MP0006036_abnormal_mitochondrial_physio2.41650982
22* MP0005620_abnormal_muscle_contractility2.41215241
23MP0005666_abnormal_adipose_tissue2.37690559
24MP0004484_altered_response_of2.33702302
25MP0002269_muscular_atrophy2.27966292
26MP0005670_abnormal_white_adipose2.26516845
27MP0004233_abnormal_muscle_weight2.19928255
28MP0002106_abnormal_muscle_physiology2.19566537
29MP0003186_abnormal_redox_activity2.19010610
30MP0000747_muscle_weakness2.18062137
31MP0001544_abnormal_cardiovascular_syste2.17754753
32MP0005385_cardiovascular_system_phenoty2.17754753
33MP0004145_abnormal_muscle_electrophysio2.15209579
34MP0003221_abnormal_cardiomyocyte_apopto2.13085709
35MP0006138_congestive_heart_failure2.07835934
36MP0003137_abnormal_impulse_conducting2.03584051
37* MP0010630_abnormal_cardiac_muscle1.94494778
38MP0000759_abnormal_skeletal_muscle1.89489518
39MP0010030_abnormal_orbit_morphology1.85890484
40MP0003941_abnormal_skin_development1.81208497
41MP0004185_abnormal_adipocyte_glucose1.80093950
42MP0005369_muscle_phenotype1.79330504
43MP0001730_embryonic_growth_arrest1.76595976
44MP0003718_maternal_effect1.72092816
45MP0008057_abnormal_DNA_replication1.68189934
46MP0003786_premature_aging1.66172441
47MP0004043_abnormal_pH_regulation1.65492935
48MP0003705_abnormal_hypodermis_morpholog1.65285124
49MP0000013_abnormal_adipose_tissue1.63933215
50MP0008007_abnormal_cellular_replicative1.61654795
51MP0001661_extended_life_span1.61062889
52MP0005375_adipose_tissue_phenotype1.60527206
53MP0003123_paternal_imprinting1.55666392
54MP0004085_abnormal_heartbeat1.55552070
55MP0009697_abnormal_copulation1.54470903
56MP0006035_abnormal_mitochondrial_morpho1.54265693
57MP0002332_abnormal_exercise_endurance1.52021648
58MP0003806_abnormal_nucleotide_metabolis1.45875229
59* MP0001697_abnormal_embryo_size1.44788561
60MP0008877_abnormal_DNA_methylation1.40326172
61MP0000372_irregular_coat_pigmentation1.36999913
62* MP0005380_embryogenesis_phenotype1.36829867
63* MP0001672_abnormal_embryogenesis/_devel1.36829867
64MP0003828_pulmonary_edema1.33733909
65MP0002971_abnormal_brown_adipose1.29865191
66MP0005332_abnormal_amino_acid1.29242757
67MP0001529_abnormal_vocalization1.27816943
68MP0009672_abnormal_birth_weight1.26533741
69MP0008995_early_reproductive_senescence1.20519208
70MP0000350_abnormal_cell_proliferation1.19239473
71MP0008438_abnormal_cutaneous_collagen1.18719108
72* MP0002080_prenatal_lethality1.16452169
73MP0001764_abnormal_homeostasis1.12078763
74MP0000003_abnormal_adipose_tissue1.11330001
75MP0002210_abnormal_sex_determination1.10334925
76MP0009780_abnormal_chondrocyte_physiolo1.09893208
77MP0005266_abnormal_metabolism1.08724261
78MP0005275_abnormal_skin_tensile1.06120107
79MP0002084_abnormal_developmental_patter1.04951732
80MP0003890_abnormal_embryonic-extraembry1.04325343
81MP0002127_abnormal_cardiovascular_syste1.04194521
82MP0003567_abnormal_fetal_cardiomyocyte1.02274396
83MP0005535_abnormal_body_temperature0.96788034
84MP0008789_abnormal_olfactory_epithelium0.96477898
85MP0000313_abnormal_cell_death0.95436086
86MP0001727_abnormal_embryo_implantation0.94538685
87MP0002909_abnormal_adrenal_gland0.93688205
88MP0005360_urolithiasis0.93211369
89MP0002085_abnormal_embryonic_tissue0.92035439
90MP0005408_hypopigmentation0.90747588
91MP0008961_abnormal_basal_metabolism0.90556007
92* MP0001929_abnormal_gametogenesis0.89553187
93MP0002938_white_spotting0.89545791
94* MP0000266_abnormal_heart_morphology0.89379571
95MP0005165_increased_susceptibility_to0.89249748
96MP0000537_abnormal_urethra_morphology0.88335364
97MP0002108_abnormal_muscle_morphology0.88221451
98MP0006292_abnormal_olfactory_placode0.87395195
99MP0002160_abnormal_reproductive_system0.87236325
100MP0003566_abnormal_cell_adhesion0.87127540
101MP0009840_abnormal_foam_cell0.86144289
102MP0002118_abnormal_lipid_homeostasis0.84586635
103MP0003315_abnormal_perineum_morphology0.84574074
104MP0005319_abnormal_enzyme/_coenzyme0.84449541
105* MP0002078_abnormal_glucose_homeostasis0.84154336
106MP0000230_abnormal_systemic_arterial0.83991433
107MP0010329_abnormal_lipoprotein_level0.83302283
108MP0001145_abnormal_male_reproductive0.83091834
109MP0004147_increased_porphyrin_level0.80889745
110MP0005584_abnormal_enzyme/coenzyme_acti0.80493352
111MP0005636_abnormal_mineral_homeostasis0.79690114
112MP0000653_abnormal_sex_gland0.77609680
113MP0003950_abnormal_plasma_membrane0.76129362
114MP0000343_altered_response_to0.75986393
115MP0002086_abnormal_extraembryonic_tissu0.75979792
116MP0005085_abnormal_gallbladder_physiolo0.75468326
117MP0001756_abnormal_urination0.73862405
118MP0003329_amyloid_beta_deposits0.73620717
119MP0005623_abnormal_meninges_morphology0.72928545
120MP0005394_taste/olfaction_phenotype0.72663290
121MP0005499_abnormal_olfactory_system0.72663290
122MP0005451_abnormal_body_composition0.71656526
123MP0003279_aneurysm0.69257595
124MP0009643_abnormal_urine_homeostasis0.68728009
125MP0003937_abnormal_limbs/digits/tail_de0.68164662
126MP0002132_abnormal_respiratory_system0.67849649
127MP0002970_abnormal_white_adipose0.67581747
128MP0003385_abnormal_body_wall0.67396089
129MP0005334_abnormal_fat_pad0.66271594
130MP0009115_abnormal_fat_cell0.66123981
131MP0001188_hyperpigmentation0.66123299
132MP0009703_decreased_birth_body0.64503722
133MP0002234_abnormal_pharynx_morphology0.64394475
134MP0004859_abnormal_synaptic_plasticity0.63837967
135MP0002877_abnormal_melanocyte_morpholog0.63471346
136MP0003698_abnormal_male_reproductive0.63228638
137MP0004272_abnormal_basement_membrane0.61734114
138MP0004858_abnormal_nervous_system0.60279839
139MP0005452_abnormal_adipose_tissue0.57511243
140MP0005365_abnormal_bile_salt0.54999394
141MP0010234_abnormal_vibrissa_follicle0.52930734
142* MP0003984_embryonic_growth_retardation0.52770835
143MP0003195_calcinosis0.52600442
144MP0005187_abnormal_penis_morphology0.52559496
145MP0001765_abnormal_ion_homeostasis0.52382919
146* MP0002088_abnormal_embryonic_growth/wei0.51855991
147MP0001958_emphysema0.51738456
148MP0000733_abnormal_muscle_development0.51638877
149MP0005448_abnormal_energy_balance0.49691819
150MP0002139_abnormal_hepatobiliary_system0.49200198
151MP0000358_abnormal_cell_content/0.49068493
152MP0010352_gastrointestinal_tract_polyps0.48517953
153MP0002128_abnormal_blood_circulation0.48069343
154MP0004924_abnormal_behavior0.47143651
155MP0005386_behavior/neurological_phenoty0.47143651
156MP0004270_analgesia0.41932939
157MP0004510_myositis0.41282528
158MP0002822_catalepsy0.41060057

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.60811825
2Exercise-induced muscle cramps (HP:0003710)5.42359365
3Exercise-induced myalgia (HP:0003738)5.32880240
4Myoglobinuria (HP:0002913)5.32573625
5Ventricular tachycardia (HP:0004756)4.54484393
6Muscle fiber splitting (HP:0003555)4.53364568
7Calf muscle hypertrophy (HP:0008981)4.48570905
8Rhabdomyolysis (HP:0003201)4.35381025
9Muscle hypertrophy of the lower extremities (HP:0008968)4.19400653
10Right ventricular cardiomyopathy (HP:0011663)3.85794679
11Hyporeflexia of lower limbs (HP:0002600)3.85323667
12Increased connective tissue (HP:0009025)3.83011727
13Abnormality of the calf musculature (HP:0001430)3.79307575
14Atrial fibrillation (HP:0005110)3.76333808
15Lipoatrophy (HP:0100578)3.67975220
16Hyperglycinuria (HP:0003108)3.65293646
17Palpitations (HP:0001962)3.63254085
18Difficulty running (HP:0009046)3.61175405
19Bundle branch block (HP:0011710)3.55967050
20Ketoacidosis (HP:0001993)3.54252830
21Primary atrial arrhythmia (HP:0001692)3.52049235
22Supraventricular tachycardia (HP:0004755)3.41803023
23Abnormality of fatty-acid metabolism (HP:0004359)3.39473907
24Supraventricular arrhythmia (HP:0005115)3.36939687
25Increased serum pyruvate (HP:0003542)3.34454493
26Abnormality of glycolysis (HP:0004366)3.34454493
27Hepatic necrosis (HP:0002605)3.33417975
28Syncope (HP:0001279)3.31712952
29EMG: myopathic abnormalities (HP:0003458)3.27922217
30Hypoglycemic coma (HP:0001325)3.14737650
31Myotonia (HP:0002486)3.12114425
32Dilated cardiomyopathy (HP:0001644)3.07874907
33Abnormality of dicarboxylic acid metabolism (HP:0010995)3.07091367
34Dicarboxylic aciduria (HP:0003215)3.07091367
35Abnormality of serine family amino acid metabolism (HP:0010894)3.06006273
36Abnormality of glycine metabolism (HP:0010895)3.06006273
37Subaortic stenosis (HP:0001682)3.03842783
38Abnormality of the left ventricular outflow tract (HP:0011103)3.03842783
39Abnormal mitochondria in muscle tissue (HP:0008316)3.02013679
40Type 1 muscle fiber predominance (HP:0003803)2.99891587
41Ventricular arrhythmia (HP:0004308)2.98388502
42* Increased serum lactate (HP:0002151)2.93944196
43Muscle fiber inclusion bodies (HP:0100299)2.92523462
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.86049787
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.86049787
46Atrioventricular block (HP:0001678)2.85710694
47Ketosis (HP:0001946)2.84207649
48Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.83835408
49Asymmetric septal hypertrophy (HP:0001670)2.83791206
50Difficulty climbing stairs (HP:0003551)2.80579697
51Hepatocellular necrosis (HP:0001404)2.78755923
52Ventricular fibrillation (HP:0001663)2.78338831
53Heart block (HP:0012722)2.78263572
54Muscle stiffness (HP:0003552)2.76748610
55Ragged-red muscle fibers (HP:0003200)2.76553402
56Acute encephalopathy (HP:0006846)2.75965850
57Conjunctival hamartoma (HP:0100780)2.75663948
58Gout (HP:0001997)2.74746525
59Acute necrotizing encephalopathy (HP:0006965)2.71198328
60Microvesicular hepatic steatosis (HP:0001414)2.70079496
61Hyperammonemia (HP:0001987)2.66090492
62Prolonged QT interval (HP:0001657)2.65618144
63Increased muscle lipid content (HP:0009058)2.65185469
64Increased variability in muscle fiber diameter (HP:0003557)2.64748637
65Abnormal atrioventricular conduction (HP:0005150)2.63518055
66Cerebral edema (HP:0002181)2.63152072
67Pheochromocytoma (HP:0002666)2.61361673
68Reticulocytopenia (HP:0001896)2.49393992
69Increased hepatocellular lipid droplets (HP:0006565)2.48521246
70Abnormality of skeletal muscle fiber size (HP:0012084)2.48352273
71* Lactic acidosis (HP:0003128)2.38923382
72Hyperglycinemia (HP:0002154)2.35751734
73Nemaline bodies (HP:0003798)2.35677137
74Dysmetric saccades (HP:0000641)2.35516037
75Progressive macrocephaly (HP:0004481)2.33397572
76Neuroendocrine neoplasm (HP:0100634)2.32917340
77Generalized aminoaciduria (HP:0002909)2.32450999
78Lipid accumulation in hepatocytes (HP:0006561)2.29947806
79Athetosis (HP:0002305)2.28914978
80Neoplasm of the adrenal gland (HP:0100631)2.27171675
81Hypobetalipoproteinemia (HP:0003563)2.25896235
82Type I transferrin isoform profile (HP:0003642)2.24533663
83Chromsome breakage (HP:0040012)2.22713647
84Hyperuricemia (HP:0002149)2.21773805
85Increased purine levels (HP:0004368)2.21773805
86Mitochondrial inheritance (HP:0001427)2.21085549
87Oligomenorrhea (HP:0000876)2.20339242
88Hamartoma of the eye (HP:0010568)2.19921070
89Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18739666
90Macrocytic anemia (HP:0001972)2.18294639
91* Increased CSF lactate (HP:0002490)2.17599379
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.16233310
93Leukodystrophy (HP:0002415)2.16052292
94Respiratory failure (HP:0002878)2.11848852
95Abnormality of methionine metabolism (HP:0010901)2.11829796
96Exercise intolerance (HP:0003546)2.11251021
97Limb-girdle muscle atrophy (HP:0003797)2.10346901
98Neck muscle weakness (HP:0000467)2.10145495
99Areflexia of lower limbs (HP:0002522)2.09413968
100Cerebral hypomyelination (HP:0006808)2.09278288
101Neoplasm of head and neck (HP:0012288)2.09203633
102Esophageal neoplasm (HP:0100751)2.09203633
103Multiple enchondromatosis (HP:0005701)2.08285837
104Distal lower limb muscle weakness (HP:0009053)2.08186877
105Proximal tubulopathy (HP:0000114)2.06710292
106Abnormal EKG (HP:0003115)2.05323014
107Abnormality of the anterior horn cell (HP:0006802)2.03436330
108Degeneration of anterior horn cells (HP:0002398)2.03436330
109Rimmed vacuoles (HP:0003805)2.02048864
110Increased intramyocellular lipid droplets (HP:0012240)2.01167774
111Facial diplegia (HP:0001349)2.00921552
112Calcaneovalgus deformity (HP:0001848)1.98573356
113* Lethargy (HP:0001254)1.97619723
114* Abnormality of serum amino acid levels (HP:0003112)1.96974392
115Generalized muscle weakness (HP:0003324)1.96604180
116* CNS demyelination (HP:0007305)1.96154970
117Metabolic acidosis (HP:0001942)1.95988283
118Birth length less than 3rd percentile (HP:0003561)1.95984186
119Spontaneous abortion (HP:0005268)1.94493420
120Resting tremor (HP:0002322)1.93637298
121Hypolipoproteinemia (HP:0010981)1.93083450
122Abnormal gallbladder physiology (HP:0012438)1.92760340
123Cholecystitis (HP:0001082)1.92760340
124Congenital malformation of the right heart (HP:0011723)1.92705309
125Double outlet right ventricle (HP:0001719)1.92705309
126Emotional lability (HP:0000712)1.92694006
127* X-linked dominant inheritance (HP:0001423)1.91500503
128Nausea (HP:0002018)1.90461167
129Progressive external ophthalmoplegia (HP:0000590)1.89474435
130Abnormality of cells of the erythroid lineage (HP:0012130)1.89397163
131Deformed tarsal bones (HP:0008119)1.87842142
132Progressive muscle weakness (HP:0003323)1.87786181
133* Abnormality of alanine metabolism (HP:0010916)1.87051685
134* Hyperalaninemia (HP:0003348)1.87051685
135* Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87051685
136Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86541333
137Renal Fanconi syndrome (HP:0001994)1.82841881
138Reduced antithrombin III activity (HP:0001976)1.82737444
139Hypoplastic left heart (HP:0004383)1.81350065
140Myopathic facies (HP:0002058)1.78149077
141Microretrognathia (HP:0000308)1.77598780
142Abnormality of urine glucose concentration (HP:0011016)1.75705985
143Glycosuria (HP:0003076)1.75705985
144Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73792666
145Abnormal protein N-linked glycosylation (HP:0012347)1.73792666
146Abnormal protein glycosylation (HP:0012346)1.73792666
147Abnormal glycosylation (HP:0012345)1.73792666
148Secondary amenorrhea (HP:0000869)1.73784885
149Abnormality of reticulocytes (HP:0004312)1.73287193
150Abnormal number of erythroid precursors (HP:0012131)1.70683858
151Horseshoe kidney (HP:0000085)1.70429166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.94274329
2PBK4.70748721
3NEK14.58724768
4BCKDK4.00270657
5LMTK23.95240869
6TRIB33.69479993
7PHKG13.65244884
8PHKG23.65244884
9OBSCN3.57244932
10PKN23.54074508
11BUB13.48394705
12STK163.00976226
13SRPK12.93448295
14NME22.89956751
15TTK2.78627524
16EIF2AK12.63092580
17CDC72.46507401
18MYLK2.45414584
19VRK22.28318353
20ERBB42.06845805
21PINK11.91243533
22PLK41.87276824
23PIK3CA1.87151672
24EIF2AK31.78819833
25WEE11.62753522
26DMPK1.61873243
27PLK31.61688442
28STK241.54898520
29TESK21.48637224
30TRIM281.46720133
31PLK11.43401836
32LATS21.41689179
33WNK41.39948470
34BRSK11.36397977
35STK38L1.26530627
36BRSK21.25925990
37PAK31.25853030
38MST41.25796027
39ATR1.16391821
40AURKB1.14825571
41* PDK21.14780610
42RIPK11.14233983
43ILK1.13613770
44MAP3K41.13183175
45MKNK11.11765483
46TIE11.11413651
47TESK11.10727522
48MAPKAPK31.08898032
49MAP2K41.08530082
50STK381.08427802
51CAMK1D1.07929880
52MAP3K71.07066601
53PRKAA11.04011224
54MAPK121.01373449
55VRK11.01044264
56FLT31.01013005
57RPS6KB21.00969109
58SIK11.00656488
59ARAF0.98112839
60CHEK10.97573349
61STK40.97557595
62CHEK20.97484584
63NME10.95459032
64PDGFRA0.93770613
65BRAF0.91787345
66MAP3K120.88885924
67WNK30.87546048
68NEK20.85646396
69FER0.84653930
70NEK90.84571295
71PIM20.84147766
72TSSK60.81319304
73AURKA0.80932571
74NUAK10.80848390
75CSNK2A20.79771380
76KSR20.77466527
77PRKAA20.77001632
78MAP3K50.76798905
79CSNK1E0.74862359
80MAP2K30.72885465
81SCYL20.72207504
82CDK190.69626688
83ATM0.69243468
84PRKD10.68896289
85PRKD30.68888162
86EEF2K0.68617698
87CAMK2D0.67645881
88CSNK2A10.67487714
89RET0.67475593
90CDK70.67467633
91DAPK30.66589841
92MKNK20.66532264
93PAK60.65852069
94ROCK10.65826905
95PNCK0.65275900
96MAP2K10.63516527
97MINK10.62645785
98AKT30.62269460
99OXSR10.62059945
100AKT20.61184621
101CDK80.60701852
102MAP3K90.59897740
103PAK40.59747350
104DAPK20.59567043
105CSNK1G30.57149499
106EIF2AK20.56132409
107CDK20.55786147
108CDK10.55506511
109PRKCI0.54325981
110STK390.54225507
111CCNB10.53591421
112LRRK20.53305959
113RAF10.53195594
114CAMK1G0.53013771
115MAP3K80.52246220
116FGFR10.52078374
117BCR0.50427932
118LIMK10.50059565
119SGK30.49945779
120CDK40.49871733
121RPS6KA40.49031703
122ABL20.46560599
123MET0.46192347
124CSNK1G10.46159337
125PRKACG0.46131830
126CDC42BPA0.45996906
127PRKDC0.45142212
128PAK10.44585517
129CAMK10.44524597
130GRK70.44189443
131PRKACB0.42986066
132DAPK10.42915413
133CAMKK10.42481107
134MAP3K30.41005281
135MAPKAPK50.40290767
136MUSK0.40174212
137MARK10.39286227
138CAMK2A0.38912265
139FRK0.38703825
140PRKCH0.37412310
141CAMK40.36537678
142ROCK20.36078361
143TAOK10.34836342
144MTOR0.34665611
145MAP2K60.34137712
146CAMK2G0.33958873
147KSR10.33565084
148CSNK1G20.33134919
149MST1R0.32892085
150PLK20.32683993
151NEK60.32603246
152PRKACA0.32447958
153CDK180.32430301
154MAPK110.32194323
155CDK11A0.32084030
156ALK0.31519492
157CSNK1A1L0.30908054
158NTRK30.30671675
159INSRR0.30037715
160PIK3CG0.30020102
161ZAK0.29563919
162* PDK10.29471404
163CDK150.28983880
164EPHA40.28941015
165WNK10.28899069
166DDR20.28708679
167TRPM70.28669853
168PTK2B0.28425666
169LATS10.28388144
170RPS6KA30.28179291

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.44301035
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.99978914
3Propanoate metabolism_Homo sapiens_hsa006404.02333519
4Fatty acid degradation_Homo sapiens_hsa000713.14143450
5Proteasome_Homo sapiens_hsa030503.03291677
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.01705138
7* Carbon metabolism_Homo sapiens_hsa012002.94896022
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.89766048
9Fatty acid metabolism_Homo sapiens_hsa012122.77203005
10DNA replication_Homo sapiens_hsa030302.76206226
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74242641
12Mismatch repair_Homo sapiens_hsa034302.49404987
13* Pyruvate metabolism_Homo sapiens_hsa006202.46805631
14Ribosome_Homo sapiens_hsa030102.30009151
15Cardiac muscle contraction_Homo sapiens_hsa042602.29660003
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11764732
17Butanoate metabolism_Homo sapiens_hsa006502.10461398
18Parkinsons disease_Homo sapiens_hsa050121.95214764
19Oxidative phosphorylation_Homo sapiens_hsa001901.94579587
20Dilated cardiomyopathy_Homo sapiens_hsa054141.87986301
21Biosynthesis of amino acids_Homo sapiens_hsa012301.84338169
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.79330322
23Base excision repair_Homo sapiens_hsa034101.79309360
24Homologous recombination_Homo sapiens_hsa034401.72491622
25RNA transport_Homo sapiens_hsa030131.67632374
26Non-homologous end-joining_Homo sapiens_hsa034501.65829133
27Fatty acid biosynthesis_Homo sapiens_hsa000611.60748791
28PPAR signaling pathway_Homo sapiens_hsa033201.60004295
29Spliceosome_Homo sapiens_hsa030401.57666919
30Nucleotide excision repair_Homo sapiens_hsa034201.57424643
31One carbon pool by folate_Homo sapiens_hsa006701.52839791
32RNA polymerase_Homo sapiens_hsa030201.51377773
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50490834
34* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.48848034
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43529197
36Alzheimers disease_Homo sapiens_hsa050101.36348765
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31758451
38Sulfur relay system_Homo sapiens_hsa041221.30342451
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28791182
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25872490
41Pyrimidine metabolism_Homo sapiens_hsa002401.25376550
42Protein export_Homo sapiens_hsa030601.23179433
43beta-Alanine metabolism_Homo sapiens_hsa004101.18487955
44Fatty acid elongation_Homo sapiens_hsa000621.14856463
45Cell cycle_Homo sapiens_hsa041101.13952748
46Huntingtons disease_Homo sapiens_hsa050161.13197566
47RNA degradation_Homo sapiens_hsa030181.12683230
48Fanconi anemia pathway_Homo sapiens_hsa034601.09734114
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09474635
50Arginine biosynthesis_Homo sapiens_hsa002201.09295856
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07309239
52Folate biosynthesis_Homo sapiens_hsa007901.01100522
53Steroid biosynthesis_Homo sapiens_hsa001001.00443317
54* Glucagon signaling pathway_Homo sapiens_hsa049221.00290568
55Tryptophan metabolism_Homo sapiens_hsa003800.99358366
56Basal transcription factors_Homo sapiens_hsa030220.99092658
57Insulin signaling pathway_Homo sapiens_hsa049100.98351684
58Starch and sucrose metabolism_Homo sapiens_hsa005000.97973175
59Purine metabolism_Homo sapiens_hsa002300.97862728
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96386989
61AMPK signaling pathway_Homo sapiens_hsa041520.95978152
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95678172
63Fructose and mannose metabolism_Homo sapiens_hsa000510.94002032
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.92435946
65Insulin resistance_Homo sapiens_hsa049310.91246041
66Nitrogen metabolism_Homo sapiens_hsa009100.88448000
67Peroxisome_Homo sapiens_hsa041460.86364675
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.83546889
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.81064767
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77847280
71Pentose phosphate pathway_Homo sapiens_hsa000300.75660585
72Galactose metabolism_Homo sapiens_hsa000520.74311467
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73426452
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72918109
75mRNA surveillance pathway_Homo sapiens_hsa030150.72806719
76Glycerolipid metabolism_Homo sapiens_hsa005610.72766283
77Selenocompound metabolism_Homo sapiens_hsa004500.69166611
78Phenylalanine metabolism_Homo sapiens_hsa003600.58872912
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58565099
80Gastric acid secretion_Homo sapiens_hsa049710.57081387
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55700146
82Arginine and proline metabolism_Homo sapiens_hsa003300.55489010
83Vitamin digestion and absorption_Homo sapiens_hsa049770.55126944
84Viral myocarditis_Homo sapiens_hsa054160.53999715
85* Central carbon metabolism in cancer_Homo sapiens_hsa052300.51258453
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49161161
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49141973
88Bile secretion_Homo sapiens_hsa049760.46890152
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46559435
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46230147
91mTOR signaling pathway_Homo sapiens_hsa041500.45123534
92Oxytocin signaling pathway_Homo sapiens_hsa049210.44920363
93Lysine degradation_Homo sapiens_hsa003100.44488372
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.44287681
95Calcium signaling pathway_Homo sapiens_hsa040200.42973498
96Renin secretion_Homo sapiens_hsa049240.42818253
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42467155
98* HIF-1 signaling pathway_Homo sapiens_hsa040660.42387892
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42384641
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40949251
101Collecting duct acid secretion_Homo sapiens_hsa049660.40330626
102Tight junction_Homo sapiens_hsa045300.39674266
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37850943
104Focal adhesion_Homo sapiens_hsa045100.36701065
105Fat digestion and absorption_Homo sapiens_hsa049750.34861455
106Vitamin B6 metabolism_Homo sapiens_hsa007500.34340846
107N-Glycan biosynthesis_Homo sapiens_hsa005100.33730882
108* Metabolic pathways_Homo sapiens_hsa011000.33005190
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31642668
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.31297398
111Type II diabetes mellitus_Homo sapiens_hsa049300.30674598
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30015953
113Synaptic vesicle cycle_Homo sapiens_hsa047210.29205394
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27419453
115Long-term potentiation_Homo sapiens_hsa047200.26824235
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25784148
117Insulin secretion_Homo sapiens_hsa049110.25182953
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22851487
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22812503
120Sulfur metabolism_Homo sapiens_hsa009200.22236043
121Salivary secretion_Homo sapiens_hsa049700.21601303
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.20911886
123Circadian rhythm_Homo sapiens_hsa047100.18004364
124Chemical carcinogenesis_Homo sapiens_hsa052040.17605267
125Circadian entrainment_Homo sapiens_hsa047130.16497158
126Retinol metabolism_Homo sapiens_hsa008300.16490389
127p53 signaling pathway_Homo sapiens_hsa041150.16420522
128Tyrosine metabolism_Homo sapiens_hsa003500.15808423
129Oocyte meiosis_Homo sapiens_hsa041140.14944795
130cAMP signaling pathway_Homo sapiens_hsa040240.14805384
131Gap junction_Homo sapiens_hsa045400.14377197
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14097590
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13215419
134Vibrio cholerae infection_Homo sapiens_hsa051100.11995503
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.11424583
136Glutathione metabolism_Homo sapiens_hsa004800.10723816
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09679096
138ECM-receptor interaction_Homo sapiens_hsa045120.09505007
139Adherens junction_Homo sapiens_hsa045200.08758435
140Protein digestion and absorption_Homo sapiens_hsa049740.07998211
141Thyroid hormone synthesis_Homo sapiens_hsa049180.07964750

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