

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | righting reflex (GO:0060013) | 6.65788933 |
| 2 | histone mRNA catabolic process (GO:0071044) | 5.26935414 |
| 3 | protein K11-linked deubiquitination (GO:0035871) | 5.15194529 |
| 4 | histone H2A monoubiquitination (GO:0035518) | 4.99683032 |
| 5 | leukotriene biosynthetic process (GO:0019370) | 4.64226764 |
| 6 | mitochondrial fragmentation involved in apoptotic process (GO:0043653) | 4.38478159 |
| 7 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 4.37097495 |
| 8 | regulation of mitotic spindle checkpoint (GO:1903504) | 4.37097495 |
| 9 | positive regulation of cardiac muscle cell proliferation (GO:0060045) | 4.31016935 |
| 10 | morphogenesis of an epithelial sheet (GO:0002011) | 4.21643538 |
| 11 | histone H2A ubiquitination (GO:0033522) | 4.17001313 |
| 12 | prenylation (GO:0097354) | 4.12455119 |
| 13 | protein prenylation (GO:0018342) | 4.12455119 |
| 14 | protein K48-linked deubiquitination (GO:0071108) | 4.07314783 |
| 15 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.91925675 |
| 16 | iron ion import (GO:0097286) | 3.83233912 |
| 17 | positive regulation of cardiac muscle tissue growth (GO:0055023) | 3.73611386 |
| 18 | mammary gland alveolus development (GO:0060749) | 3.73429463 |
| 19 | neural tube formation (GO:0001841) | 3.68242972 |
| 20 | mitochondrial fission (GO:0000266) | 3.63630954 |
| 21 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.63157414 |
| 22 | photoreceptor cell maintenance (GO:0045494) | 3.54847299 |
| 23 | detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580) | 3.52909888 |
| 24 | histone H2A acetylation (GO:0043968) | 3.52762417 |
| 25 | cullin deneddylation (GO:0010388) | 3.50742822 |
| 26 | mechanosensory behavior (GO:0007638) | 3.48027300 |
| 27 | protein deneddylation (GO:0000338) | 3.45419659 |
| 28 | regulation of translation, ncRNA-mediated (GO:0045974) | 3.44140258 |
| 29 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 3.44140258 |
| 30 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 3.44140258 |
| 31 | regulation of sarcomere organization (GO:0060297) | 3.42568366 |
| 32 | reflex (GO:0060004) | 3.41946476 |
| 33 | negative regulation of transcription regulatory region DNA binding (GO:2000678) | 3.41513969 |
| 34 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 3.38475124 |
| 35 | mitochondrion distribution (GO:0048311) | 3.37579928 |
| 36 | mRNA cleavage (GO:0006379) | 3.34241389 |
| 37 | auditory behavior (GO:0031223) | 3.34052680 |
| 38 | histone mRNA metabolic process (GO:0008334) | 3.33463558 |
| 39 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 3.32469281 |
| 40 | regulation of hippo signaling (GO:0035330) | 3.31092265 |
| 41 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.28824908 |
| 42 | negative regulation of histone methylation (GO:0031061) | 3.26810570 |
| 43 | regulation of cardiac muscle cell proliferation (GO:0060043) | 3.24258134 |
| 44 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.20827325 |
| 45 | negative regulation of execution phase of apoptosis (GO:1900118) | 3.20376491 |
| 46 | response to hydroperoxide (GO:0033194) | 3.19561702 |
| 47 | basic amino acid transport (GO:0015802) | 3.19378793 |
| 48 | forebrain neuron differentiation (GO:0021879) | 3.17657912 |
| 49 | olfactory bulb development (GO:0021772) | 3.15274017 |
| 50 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.13138768 |
| 51 | positive regulation of heart growth (GO:0060421) | 3.03211556 |
| 52 | replication fork processing (GO:0031297) | 3.03179639 |
| 53 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 3.02735953 |
| 54 | positive regulation of cardiac muscle tissue development (GO:0055025) | 3.02417245 |
| 55 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 3.01560342 |
| 56 | smooth muscle tissue development (GO:0048745) | 3.01120490 |
| 57 | Notch signaling involved in heart development (GO:0061314) | 3.00966314 |
| 58 | leukotriene metabolic process (GO:0006691) | 3.00935892 |
| 59 | protein K63-linked deubiquitination (GO:0070536) | 3.00135428 |
| 60 | ventricular trabecula myocardium morphogenesis (GO:0003222) | 2.94633552 |
| 61 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.93582972 |
| 62 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.92844626 |
| 63 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.90665189 |
| 64 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.90665189 |
| 65 | response to pheromone (GO:0019236) | 2.87353687 |
| 66 | detection of chemical stimulus involved in sensory perception of taste (GO:0050912) | 2.83964556 |
| 67 | ncRNA catabolic process (GO:0034661) | 2.83735448 |
| 68 | branched-chain amino acid catabolic process (GO:0009083) | 2.80537264 |
| 69 | nodal signaling pathway (GO:0038092) | 2.79156691 |
| 70 | glutamine metabolic process (GO:0006541) | 2.74040378 |
| 71 | cilium or flagellum-dependent cell motility (GO:0001539) | 2.70652903 |
| 72 | negative regulation of B cell proliferation (GO:0030889) | 2.70340308 |
| 73 | regulation of histone H3-K4 methylation (GO:0051569) | 2.68794520 |
| 74 | early endosome to late endosome transport (GO:0045022) | 2.67424260 |
| 75 | response to redox state (GO:0051775) | 2.67414183 |
| 76 | negative regulation of DNA recombination (GO:0045910) | 2.66312755 |
| 77 | protein maturation by protein folding (GO:0022417) | 2.65552081 |
| 78 | protein modification by small protein removal (GO:0070646) | 2.63835767 |
| 79 | regulation of neurotransmitter uptake (GO:0051580) | 2.63085249 |
| 80 | DNA double-strand break processing (GO:0000729) | 2.60173827 |
| 81 | rRNA catabolic process (GO:0016075) | 2.59325163 |
| 82 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.57123243 |
| 83 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.56534624 |
| 84 | resolution of meiotic recombination intermediates (GO:0000712) | 2.55375980 |
| 85 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.54666509 |
| 86 | telomere maintenance via telomerase (GO:0007004) | 2.54596758 |
| 87 | positive regulation of bone mineralization (GO:0030501) | 2.54554365 |
| 88 | sister chromatid segregation (GO:0000819) | 2.54006798 |
| 89 | anterior/posterior axis specification, embryo (GO:0008595) | 2.52140093 |
| 90 | signal peptide processing (GO:0006465) | 2.51419400 |
| 91 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.51182479 |
| 92 | mitotic recombination (GO:0006312) | 2.51040794 |
| 93 | retinal cone cell development (GO:0046549) | 2.50664007 |
| 94 | S-adenosylmethionine metabolic process (GO:0046500) | 2.49386794 |
| 95 | chromatin remodeling at centromere (GO:0031055) | 2.48510625 |
| 96 | protein deubiquitination (GO:0016579) | 2.47043196 |
| 97 | dorsal/ventral axis specification (GO:0009950) | 2.46807308 |
| 98 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 2.46134840 |
| 99 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.45953327 |
| 100 | telomere maintenance via recombination (GO:0000722) | 2.45490150 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 5.54623682 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.86562335 |
| 3 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 3.45140410 |
| 4 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.88401859 |
| 5 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.83705252 |
| 6 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.79125655 |
| 7 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.77312004 |
| 8 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.70347911 |
| 9 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.69955599 |
| 10 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.51490567 |
| 11 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.48141587 |
| 12 | EWS_26573619_Chip-Seq_HEK293_Human | 2.33444480 |
| 13 | VDR_22108803_ChIP-Seq_LS180_Human | 2.29825100 |
| 14 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.23745754 |
| 15 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 2.22689341 |
| 16 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.14330735 |
| 17 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.09991243 |
| 18 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 2.03140167 |
| 19 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.01639644 |
| 20 | FUS_26573619_Chip-Seq_HEK293_Human | 2.01170667 |
| 21 | P300_19829295_ChIP-Seq_ESCs_Human | 1.91518133 |
| 22 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.87071524 |
| 23 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.86929522 |
| 24 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.86415402 |
| 25 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.77783310 |
| 26 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.77783310 |
| 27 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.75239772 |
| 28 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.75083123 |
| 29 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.74568059 |
| 30 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.74568059 |
| 31 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.68128646 |
| 32 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.64992960 |
| 33 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.64754578 |
| 34 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.64117795 |
| 35 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.58096651 |
| 36 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.54717475 |
| 37 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.53733583 |
| 38 | STAT3_23295773_ChIP-Seq_U87_Human | 1.53614271 |
| 39 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.52595404 |
| 40 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.46908521 |
| 41 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.46665672 |
| 42 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.44747428 |
| 43 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.43587418 |
| 44 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.43587418 |
| 45 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.38275227 |
| 46 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.36802601 |
| 47 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.36194853 |
| 48 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.35568002 |
| 49 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.34294737 |
| 50 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.34007170 |
| 51 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.33304539 |
| 52 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.32949384 |
| 53 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.32703749 |
| 54 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.30850478 |
| 55 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.28316670 |
| 56 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.26960591 |
| 57 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.26104564 |
| 58 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.24552908 |
| 59 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.23236479 |
| 60 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.23169536 |
| 61 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.22046965 |
| 62 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.21785869 |
| 63 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.20910907 |
| 64 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.20704210 |
| 65 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.20443119 |
| 66 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.20204150 |
| 67 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.19454946 |
| 68 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.19428723 |
| 69 | TCF4_23295773_ChIP-Seq_U87_Human | 1.17140889 |
| 70 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.16004051 |
| 71 | AR_25329375_ChIP-Seq_VCAP_Human | 1.14630263 |
| 72 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.13439298 |
| 73 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.12441276 |
| 74 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.10306585 |
| 75 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.09846180 |
| 76 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.08953825 |
| 77 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 1.07975617 |
| 78 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.06953896 |
| 79 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.05553119 |
| 80 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.05123143 |
| 81 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.04481303 |
| 82 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.03779338 |
| 83 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.03559634 |
| 84 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.02104360 |
| 85 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.01871914 |
| 86 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.01394405 |
| 87 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.99542212 |
| 88 | CTCF_18555785_Chip-Seq_ESCs_Mouse | 0.99102799 |
| 89 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 0.97935838 |
| 90 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 0.97534025 |
| 91 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.95382144 |
| 92 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.95151835 |
| 93 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.94597066 |
| 94 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.92525245 |
| 95 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.90568588 |
| 96 | TP53_16413492_ChIP-PET_HCT116_Human | 0.90124123 |
| 97 | KLF4_18555785_Chip-Seq_ESCs_Mouse | 0.90088021 |
| 98 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.88219728 |
| 99 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.87853964 |
| 100 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.87086285 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008057_abnormal_DNA_replication | 4.50151128 |
| 2 | MP0000569_abnormal_digit_pigmentation | 4.47654167 |
| 3 | MP0003786_premature_aging | 4.11158890 |
| 4 | MP0010234_abnormal_vibrissa_follicle | 4.03843813 |
| 5 | MP0001529_abnormal_vocalization | 3.04918205 |
| 6 | MP0005666_abnormal_adipose_tissue | 2.62016638 |
| 7 | MP0003137_abnormal_impulse_conducting | 2.53004766 |
| 8 | MP0003890_abnormal_embryonic-extraembry | 2.44708161 |
| 9 | MP0001958_emphysema | 2.44257273 |
| 10 | MP0004019_abnormal_vitamin_homeostasis | 2.30739459 |
| 11 | MP0004147_increased_porphyrin_level | 2.22710678 |
| 12 | MP0005084_abnormal_gallbladder_morpholo | 2.19471358 |
| 13 | MP0005670_abnormal_white_adipose | 2.07469613 |
| 14 | MP0010678_abnormal_skin_adnexa | 1.96881431 |
| 15 | MP0002102_abnormal_ear_morphology | 1.96703212 |
| 16 | MP0003195_calcinosis | 1.95915441 |
| 17 | MP0008877_abnormal_DNA_methylation | 1.88422281 |
| 18 | MP0003567_abnormal_fetal_cardiomyocyte | 1.88187508 |
| 19 | MP0005379_endocrine/exocrine_gland_phen | 1.86811227 |
| 20 | MP0010094_abnormal_chromosome_stability | 1.86715608 |
| 21 | MP0002837_dystrophic_cardiac_calcinosis | 1.84803127 |
| 22 | MP0002254_reproductive_system_inflammat | 1.82599607 |
| 23 | MP0008058_abnormal_DNA_repair | 1.77542905 |
| 24 | MP0006072_abnormal_retinal_apoptosis | 1.76944583 |
| 25 | MP0003252_abnormal_bile_duct | 1.76234528 |
| 26 | MP0002163_abnormal_gland_morphology | 1.73068411 |
| 27 | MP0000631_abnormal_neuroendocrine_gland | 1.72576386 |
| 28 | MP0003186_abnormal_redox_activity | 1.72475440 |
| 29 | MP0000427_abnormal_hair_cycle | 1.61720914 |
| 30 | MP0002168_other_aberrant_phenotype | 1.55764524 |
| 31 | MP0001765_abnormal_ion_homeostasis | 1.44387952 |
| 32 | MP0002928_abnormal_bile_duct | 1.43362338 |
| 33 | MP0005551_abnormal_eye_electrophysiolog | 1.42527322 |
| 34 | MP0003656_abnormal_erythrocyte_physiolo | 1.41849102 |
| 35 | MP0005395_other_phenotype | 1.37032833 |
| 36 | MP0008007_abnormal_cellular_replicative | 1.35743516 |
| 37 | MP0002971_abnormal_brown_adipose | 1.33852331 |
| 38 | MP0005623_abnormal_meninges_morphology | 1.31207069 |
| 39 | MP0003718_maternal_effect | 1.30499478 |
| 40 | MP0001486_abnormal_startle_reflex | 1.28486328 |
| 41 | MP0000383_abnormal_hair_follicle | 1.27373276 |
| 42 | MP0001188_hyperpigmentation | 1.26664805 |
| 43 | MP0005375_adipose_tissue_phenotype | 1.24566618 |
| 44 | MP0003941_abnormal_skin_development | 1.24182818 |
| 45 | MP0008995_early_reproductive_senescence | 1.24134327 |
| 46 | MP0003950_abnormal_plasma_membrane | 1.22117133 |
| 47 | MP0002693_abnormal_pancreas_physiology | 1.20771561 |
| 48 | MP0002108_abnormal_muscle_morphology | 1.19880112 |
| 49 | MP0008961_abnormal_basal_metabolism | 1.17971246 |
| 50 | MP0005083_abnormal_biliary_tract | 1.14080915 |
| 51 | MP0005253_abnormal_eye_physiology | 1.13046373 |
| 52 | MP0002736_abnormal_nociception_after | 1.12452418 |
| 53 | MP0002970_abnormal_white_adipose | 1.07529708 |
| 54 | MP0001485_abnormal_pinna_reflex | 1.07229197 |
| 55 | MP0005386_behavior/neurological_phenoty | 1.07063884 |
| 56 | MP0004924_abnormal_behavior | 1.07063884 |
| 57 | MP0008932_abnormal_embryonic_tissue | 1.00911002 |
| 58 | MP0003787_abnormal_imprinting | 0.98741223 |
| 59 | MP0002234_abnormal_pharynx_morphology | 0.97921569 |
| 60 | MP0003077_abnormal_cell_cycle | 0.97477536 |
| 61 | MP0005501_abnormal_skin_physiology | 0.97319120 |
| 62 | MP0003111_abnormal_nucleus_morphology | 0.97103616 |
| 63 | MP0001501_abnormal_sleep_pattern | 0.96432148 |
| 64 | MP0001944_abnormal_pancreas_morphology | 0.96174903 |
| 65 | MP0005174_abnormal_tail_pigmentation | 0.94632295 |
| 66 | MP0005636_abnormal_mineral_homeostasis | 0.93350215 |
| 67 | MP0003937_abnormal_limbs/digits/tail_de | 0.93339106 |
| 68 | MP0000377_abnormal_hair_follicle | 0.93275267 |
| 69 | MP0003693_abnormal_embryo_hatching | 0.92820064 |
| 70 | MP0005535_abnormal_body_temperature | 0.91923684 |
| 71 | MP0002090_abnormal_vision | 0.90307178 |
| 72 | MP0003121_genomic_imprinting | 0.86920660 |
| 73 | MP0004270_analgesia | 0.83836704 |
| 74 | MP0006292_abnormal_olfactory_placode | 0.83658518 |
| 75 | MP0001881_abnormal_mammary_gland | 0.83372512 |
| 76 | MP0005647_abnormal_sex_gland | 0.82708473 |
| 77 | MP0001191_abnormal_skin_condition | 0.82650277 |
| 78 | MP0000371_diluted_coat_color | 0.80877538 |
| 79 | MP0005220_abnormal_exocrine_pancreas | 0.78728429 |
| 80 | MP0001293_anophthalmia | 0.78512421 |
| 81 | MP0002177_abnormal_outer_ear | 0.78071123 |
| 82 | MP0000647_abnormal_sebaceous_gland | 0.77770782 |
| 83 | MP0002009_preneoplasia | 0.76944697 |
| 84 | MP0000470_abnormal_stomach_morphology | 0.75419429 |
| 85 | MP0001929_abnormal_gametogenesis | 0.74144598 |
| 86 | MP0001764_abnormal_homeostasis | 0.72119972 |
| 87 | MP0002876_abnormal_thyroid_physiology | 0.71053074 |
| 88 | MP0005266_abnormal_metabolism | 0.68242539 |
| 89 | MP0002088_abnormal_embryonic_growth/wei | 0.66822875 |
| 90 | MP0004957_abnormal_blastocyst_morpholog | 0.65937628 |
| 91 | MP0004742_abnormal_vestibular_system | 0.65417029 |
| 92 | MP0004085_abnormal_heartbeat | 0.65106190 |
| 93 | MP0005408_hypopigmentation | 0.65021041 |
| 94 | MP0002078_abnormal_glucose_homeostasis | 0.64695193 |
| 95 | MP0003984_embryonic_growth_retardation | 0.64532211 |
| 96 | MP0001968_abnormal_touch/_nociception | 0.63227096 |
| 97 | MP0005310_abnormal_salivary_gland | 0.61953644 |
| 98 | MP0003183_abnormal_peptide_metabolism | 0.60971366 |
| 99 | MP0002938_white_spotting | 0.60608463 |
| 100 | MP0000613_abnormal_salivary_gland | 0.60124503 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Progressive inability to walk (HP:0002505) | 6.54139721 |
| 2 | Vascular calcification (HP:0004934) | 5.96970549 |
| 3 | Submucous cleft hard palate (HP:0000176) | 5.55938498 |
| 4 | Cardiovascular calcification (HP:0011915) | 5.23957124 |
| 5 | Septate vagina (HP:0001153) | 5.07280589 |
| 6 | Large for gestational age (HP:0001520) | 4.25574897 |
| 7 | Hyperphosphatemia (HP:0002905) | 4.25515830 |
| 8 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.89624026 |
| 9 | Abnormality of alanine metabolism (HP:0010916) | 3.89624026 |
| 10 | Hyperalaninemia (HP:0003348) | 3.89624026 |
| 11 | Taurodontia (HP:0000679) | 3.76907572 |
| 12 | Abnormality of permanent molar morphology (HP:0011071) | 3.76907572 |
| 13 | Abnormality of the dental root (HP:0006486) | 3.76907572 |
| 14 | Inability to walk (HP:0002540) | 3.69696988 |
| 15 | Abnormality of renal resorption (HP:0011038) | 3.66958998 |
| 16 | Protruding tongue (HP:0010808) | 3.60718201 |
| 17 | Persistence of primary teeth (HP:0006335) | 3.55758467 |
| 18 | Abnormality of molar (HP:0011077) | 3.48002545 |
| 19 | Abnormality of molar morphology (HP:0011070) | 3.48002545 |
| 20 | Abnormality of the dental pulp (HP:0006479) | 3.45512953 |
| 21 | Dyschromatopsia (HP:0007641) | 3.21939516 |
| 22 | Optic nerve coloboma (HP:0000588) | 3.03727446 |
| 23 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.94804415 |
| 24 | Abnormal number of incisors (HP:0011064) | 2.90963665 |
| 25 | Abnormality of renal excretion (HP:0011036) | 2.83980868 |
| 26 | Pancreatic cysts (HP:0001737) | 2.76921883 |
| 27 | Febrile seizures (HP:0002373) | 2.69475303 |
| 28 | Exotropia (HP:0000577) | 2.67830896 |
| 29 | Duplicated collecting system (HP:0000081) | 2.63804378 |
| 30 | Midline defect of the nose (HP:0004122) | 2.56224847 |
| 31 | Rectal fistula (HP:0100590) | 2.55371868 |
| 32 | Rectovaginal fistula (HP:0000143) | 2.55371868 |
| 33 | Abnormality of chromosome stability (HP:0003220) | 2.55138364 |
| 34 | Abnormality of the labia minora (HP:0012880) | 2.50473423 |
| 35 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.37829427 |
| 36 | Intestinal atresia (HP:0011100) | 2.36524026 |
| 37 | Abnormality of the renal collecting system (HP:0004742) | 2.34382534 |
| 38 | Pancreatic fibrosis (HP:0100732) | 2.33895441 |
| 39 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.33285923 |
| 40 | Abnormality of the renal cortex (HP:0011035) | 2.32330399 |
| 41 | Abnormality of the pons (HP:0007361) | 2.30282233 |
| 42 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.23657625 |
| 43 | Thyroiditis (HP:0100646) | 2.22146203 |
| 44 | Increased number of teeth (HP:0011069) | 2.21630141 |
| 45 | Intestinal fistula (HP:0100819) | 2.21434430 |
| 46 | Oligodactyly (hands) (HP:0001180) | 2.19319699 |
| 47 | Medial flaring of the eyebrow (HP:0010747) | 2.16190256 |
| 48 | Tubulointerstitial nephritis (HP:0001970) | 2.13714518 |
| 49 | Nephronophthisis (HP:0000090) | 2.13487756 |
| 50 | Nephrocalcinosis (HP:0000121) | 2.13130884 |
| 51 | Absent speech (HP:0001344) | 2.12909692 |
| 52 | Genetic anticipation (HP:0003743) | 2.12390394 |
| 53 | Preaxial hand polydactyly (HP:0001177) | 2.12034409 |
| 54 | Clitoromegaly (HP:0000057) | 2.09740709 |
| 55 | Asplenia (HP:0001746) | 2.09187662 |
| 56 | Tetraparesis (HP:0002273) | 2.08889392 |
| 57 | Abnormality of the renal medulla (HP:0100957) | 2.05360530 |
| 58 | Abnormality of the ileum (HP:0001549) | 2.05319412 |
| 59 | Methylmalonic acidemia (HP:0002912) | 2.03829653 |
| 60 | Chromsome breakage (HP:0040012) | 2.02538117 |
| 61 | Fair hair (HP:0002286) | 2.02310793 |
| 62 | Vaginal fistula (HP:0004320) | 2.02124788 |
| 63 | Supernumerary spleens (HP:0009799) | 1.96119685 |
| 64 | Molar tooth sign on MRI (HP:0002419) | 1.94993040 |
| 65 | Abnormality of midbrain morphology (HP:0002418) | 1.94993040 |
| 66 | Genital tract atresia (HP:0001827) | 1.93984762 |
| 67 | Rhabdomyosarcoma (HP:0002859) | 1.93485435 |
| 68 | Decreased circulating renin level (HP:0003351) | 1.92954084 |
| 69 | Insulin-resistant diabetes mellitus (HP:0000831) | 1.92356239 |
| 70 | Chronic hepatic failure (HP:0100626) | 1.90850268 |
| 71 | Meckel diverticulum (HP:0002245) | 1.90204878 |
| 72 | Medulloblastoma (HP:0002885) | 1.86768766 |
| 73 | Azoospermia (HP:0000027) | 1.86459119 |
| 74 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.85922330 |
| 75 | Tubular atrophy (HP:0000092) | 1.85826444 |
| 76 | Hypothermia (HP:0002045) | 1.84322076 |
| 77 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.78023519 |
| 78 | Vaginal atresia (HP:0000148) | 1.77927479 |
| 79 | Attenuation of retinal blood vessels (HP:0007843) | 1.77647931 |
| 80 | Abnormal biliary tract physiology (HP:0012439) | 1.76649883 |
| 81 | Bile duct proliferation (HP:0001408) | 1.76649883 |
| 82 | Hip dysplasia (HP:0001385) | 1.75222340 |
| 83 | True hermaphroditism (HP:0010459) | 1.73311301 |
| 84 | Renal cortical cysts (HP:0000803) | 1.73133957 |
| 85 | Abnormal spermatogenesis (HP:0008669) | 1.71266243 |
| 86 | Cone-rod dystrophy (HP:0000548) | 1.70960757 |
| 87 | Abnormality of the preputium (HP:0100587) | 1.70843147 |
| 88 | Absent septum pellucidum (HP:0001331) | 1.70388123 |
| 89 | Carpal bone hypoplasia (HP:0001498) | 1.69832987 |
| 90 | Neoplasm of striated muscle (HP:0009728) | 1.68866233 |
| 91 | Bifid tongue (HP:0010297) | 1.68099262 |
| 92 | Abnormality of endocrine pancreas physiology (HP:0012093) | 1.66561389 |
| 93 | Abnormality of the pancreatic islet cells (HP:0006476) | 1.66561389 |
| 94 | Hypoproteinemia (HP:0003075) | 1.65033780 |
| 95 | Progressive cerebellar ataxia (HP:0002073) | 1.64678101 |
| 96 | Neoplasm of the oral cavity (HP:0100649) | 1.64650966 |
| 97 | Ependymoma (HP:0002888) | 1.64199994 |
| 98 | Absent radius (HP:0003974) | 1.63993543 |
| 99 | Congenital primary aphakia (HP:0007707) | 1.63877513 |
| 100 | Abolished electroretinogram (ERG) (HP:0000550) | 1.62649646 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ERBB4 | 6.45697357 |
| 2 | PDK2 | 4.31415122 |
| 3 | FRK | 3.80802242 |
| 4 | TRIM28 | 3.10680326 |
| 5 | AKT3 | 2.84448195 |
| 6 | WNK3 | 2.82347433 |
| 7 | ACVR1B | 2.72629177 |
| 8 | EIF2AK3 | 2.36650177 |
| 9 | TAOK1 | 2.30457635 |
| 10 | MAP3K14 | 2.23513265 |
| 11 | MKNK2 | 2.08801471 |
| 12 | BUB1 | 1.93867244 |
| 13 | NLK | 1.92640885 |
| 14 | INSRR | 1.90541140 |
| 15 | MKNK1 | 1.69047697 |
| 16 | PIK3CG | 1.55264035 |
| 17 | OXSR1 | 1.43014537 |
| 18 | TSSK6 | 1.37533388 |
| 19 | CSNK1G1 | 1.19172204 |
| 20 | STK16 | 1.18120968 |
| 21 | TNIK | 1.18051148 |
| 22 | STK3 | 1.13271958 |
| 23 | TGFBR2 | 1.09862031 |
| 24 | SGK2 | 1.09802385 |
| 25 | MST4 | 1.09582660 |
| 26 | CAMKK2 | 1.08345338 |
| 27 | STK38L | 1.05995315 |
| 28 | BRSK2 | 1.04084440 |
| 29 | PAK3 | 1.04034118 |
| 30 | STK24 | 0.99451358 |
| 31 | CASK | 0.97259275 |
| 32 | ADRBK2 | 0.95309191 |
| 33 | MARK3 | 0.90504509 |
| 34 | CAMK4 | 0.89169919 |
| 35 | SRPK1 | 0.88882559 |
| 36 | BMPR1B | 0.88109723 |
| 37 | PBK | 0.87370005 |
| 38 | DYRK3 | 0.87188442 |
| 39 | STK11 | 0.83389009 |
| 40 | CSNK1A1L | 0.79133083 |
| 41 | NUAK1 | 0.78461564 |
| 42 | WNK4 | 0.78301253 |
| 43 | MAP4K2 | 0.77848292 |
| 44 | TTK | 0.76133756 |
| 45 | PLK1 | 0.76112085 |
| 46 | ZAK | 0.75634555 |
| 47 | PLK3 | 0.72746228 |
| 48 | EIF2AK2 | 0.72692427 |
| 49 | STK10 | 0.72429218 |
| 50 | CDK9 | 0.72104332 |
| 51 | PLK4 | 0.69927772 |
| 52 | DYRK1A | 0.69663193 |
| 53 | BCR | 0.65759814 |
| 54 | MAPK13 | 0.65587062 |
| 55 | KSR1 | 0.65343869 |
| 56 | OBSCN | 0.63250764 |
| 57 | STK4 | 0.61458215 |
| 58 | TNK2 | 0.60116980 |
| 59 | ATM | 0.58418068 |
| 60 | YES1 | 0.57906880 |
| 61 | GRK7 | 0.57212509 |
| 62 | CDK3 | 0.55957361 |
| 63 | TLK1 | 0.55581523 |
| 64 | MAP3K4 | 0.55437990 |
| 65 | SGK223 | 0.54839779 |
| 66 | SGK494 | 0.54839779 |
| 67 | GRK1 | 0.53889082 |
| 68 | STK39 | 0.53886194 |
| 69 | ATR | 0.53818845 |
| 70 | TEC | 0.53798868 |
| 71 | ERBB3 | 0.53180909 |
| 72 | NEK1 | 0.51576928 |
| 73 | MARK2 | 0.51502688 |
| 74 | CAMK2A | 0.51380880 |
| 75 | BRAF | 0.51112194 |
| 76 | CAMK1G | 0.50023303 |
| 77 | WEE1 | 0.49683870 |
| 78 | TGFBR1 | 0.49013596 |
| 79 | PRKCE | 0.48302349 |
| 80 | AURKB | 0.47108998 |
| 81 | FES | 0.46930134 |
| 82 | CAMK1D | 0.46051107 |
| 83 | TAOK3 | 0.45097349 |
| 84 | PRKCI | 0.44121439 |
| 85 | CSNK1G3 | 0.43778524 |
| 86 | BLK | 0.42782015 |
| 87 | SGK3 | 0.41358866 |
| 88 | PRKCQ | 0.41004000 |
| 89 | BRD4 | 0.40125204 |
| 90 | CAMK2D | 0.39423597 |
| 91 | PIK3CA | 0.36472345 |
| 92 | ERBB2 | 0.35386264 |
| 93 | CHEK2 | 0.35263262 |
| 94 | MAP2K2 | 0.34166274 |
| 95 | FGFR2 | 0.33960786 |
| 96 | CDK8 | 0.33799598 |
| 97 | CSNK1G2 | 0.33503345 |
| 98 | PIM1 | 0.33396892 |
| 99 | FLT3 | 0.32000059 |
| 100 | CHEK1 | 0.31938549 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 3.57428512 |
| 2 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 3.34601447 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.11694780 |
| 4 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.88984409 |
| 5 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.74130926 |
| 6 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 2.63575748 |
| 7 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.63321597 |
| 8 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.39958968 |
| 9 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.22499155 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.20375855 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.18052946 |
| 12 | Circadian rhythm_Homo sapiens_hsa04710 | 2.08220874 |
| 13 | Selenocompound metabolism_Homo sapiens_hsa00450 | 2.05763949 |
| 14 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.05390032 |
| 15 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 2.01300492 |
| 16 | DNA replication_Homo sapiens_hsa03030 | 1.97122677 |
| 17 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.94448032 |
| 18 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.91097664 |
| 19 | Taste transduction_Homo sapiens_hsa04742 | 1.90143101 |
| 20 | RNA degradation_Homo sapiens_hsa03018 | 1.77740268 |
| 21 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.70578549 |
| 22 | Phototransduction_Homo sapiens_hsa04744 | 1.66813870 |
| 23 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.66490030 |
| 24 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.64828804 |
| 25 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.58300835 |
| 26 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.45158783 |
| 27 | RNA transport_Homo sapiens_hsa03013 | 1.40505206 |
| 28 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.38466921 |
| 29 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.37852581 |
| 30 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.33774731 |
| 31 | Nicotine addiction_Homo sapiens_hsa05033 | 1.28608090 |
| 32 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.27732537 |
| 33 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.12742486 |
| 34 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.11601648 |
| 35 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.07727624 |
| 36 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.07369663 |
| 37 | RNA polymerase_Homo sapiens_hsa03020 | 1.06758231 |
| 38 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.05295562 |
| 39 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.04465349 |
| 40 | Lysine degradation_Homo sapiens_hsa00310 | 1.02072273 |
| 41 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.00576729 |
| 42 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.98764431 |
| 43 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.96842989 |
| 44 | Protein export_Homo sapiens_hsa03060 | 0.92083221 |
| 45 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.88598631 |
| 46 | GABAergic synapse_Homo sapiens_hsa04727 | 0.88164390 |
| 47 | Asthma_Homo sapiens_hsa05310 | 0.85624256 |
| 48 | Colorectal cancer_Homo sapiens_hsa05210 | 0.83681934 |
| 49 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.81721328 |
| 50 | Basal transcription factors_Homo sapiens_hsa03022 | 0.80554312 |
| 51 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.80129478 |
| 52 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.79003530 |
| 53 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.74073716 |
| 54 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.72265381 |
| 55 | Legionellosis_Homo sapiens_hsa05134 | 0.71109872 |
| 56 | Cell cycle_Homo sapiens_hsa04110 | 0.69773859 |
| 57 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.69390791 |
| 58 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.68540889 |
| 59 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.66819771 |
| 60 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.66597772 |
| 61 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.65466744 |
| 62 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.62958723 |
| 63 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.61586904 |
| 64 | Alcoholism_Homo sapiens_hsa05034 | 0.61131832 |
| 65 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.60739786 |
| 66 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.57839504 |
| 67 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.56996127 |
| 68 | Purine metabolism_Homo sapiens_hsa00230 | 0.54744337 |
| 69 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.50665249 |
| 70 | Proteasome_Homo sapiens_hsa03050 | 0.49447795 |
| 71 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.48268901 |
| 72 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.47844936 |
| 73 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.45981467 |
| 74 | Circadian entrainment_Homo sapiens_hsa04713 | 0.43567161 |
| 75 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.43358627 |
| 76 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.43222975 |
| 77 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.42874603 |
| 78 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.41463689 |
| 79 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.41437158 |
| 80 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.40378135 |
| 81 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.40154369 |
| 82 | Metabolic pathways_Homo sapiens_hsa01100 | 0.39751190 |
| 83 | Spliceosome_Homo sapiens_hsa03040 | 0.39731850 |
| 84 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.37985284 |
| 85 | Morphine addiction_Homo sapiens_hsa05032 | 0.37305216 |
| 86 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.34141727 |
| 87 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.30228293 |
| 88 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.30176371 |
| 89 | Base excision repair_Homo sapiens_hsa03410 | 0.28465475 |
| 90 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.28373092 |
| 91 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.28256960 |
| 92 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.27729730 |
| 93 | Olfactory transduction_Homo sapiens_hsa04740 | 0.26987173 |
| 94 | Histidine metabolism_Homo sapiens_hsa00340 | 0.25450812 |
| 95 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.23873721 |
| 96 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.23636025 |
| 97 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.22395833 |
| 98 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.21632310 |
| 99 | ABC transporters_Homo sapiens_hsa02010 | 0.21020000 |
| 100 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.18504080 |

