PDHA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.94364125
2binding of sperm to zona pellucida (GO:0007339)9.83337560
3plasma membrane fusion (GO:0045026)9.79199211
4acrosome reaction (GO:0007340)9.66969088
5epithelial cilium movement (GO:0003351)9.46932365
6cell-cell recognition (GO:0009988)9.43246947
7synaptonemal complex organization (GO:0070193)9.31471054
8spermatid development (GO:0007286)9.10345550
9motile cilium assembly (GO:0044458)8.97328895
10synaptonemal complex assembly (GO:0007130)8.96435623
11reproduction (GO:0000003)8.73526828
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.14895559
13cilium movement (GO:0003341)8.04670912
14DNA methylation involved in gamete generation (GO:0043046)7.61329271
15regulation of cilium movement (GO:0003352)7.18015256
16single fertilization (GO:0007338)6.97480752
17male meiosis I (GO:0007141)6.70718612
18chromosome organization involved in meiosis (GO:0070192)6.40443631
19fertilization (GO:0009566)6.25615640
20negative regulation of inclusion body assembly (GO:0090084)6.20913039
21sperm capacitation (GO:0048240)6.12118029
22meiotic nuclear division (GO:0007126)6.01328498
23spermatogenesis (GO:0007283)5.93210502
24male gamete generation (GO:0048232)5.91312032
25meiosis I (GO:0007127)5.47798346
26gamete generation (GO:0007276)5.45836834
27germ cell development (GO:0007281)5.44301975
28microtubule depolymerization (GO:0007019)5.41845692
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.29420850
30ventricular system development (GO:0021591)5.02256529
31regulation of inclusion body assembly (GO:0090083)5.00007127
32meiotic cell cycle (GO:0051321)4.90222222
33organic cation transport (GO:0015695)4.70650054
34seminiferous tubule development (GO:0072520)4.61869876
35regulation of meiosis I (GO:0060631)4.51491582
36cell recognition (GO:0008037)4.49933487
37calcium ion-dependent exocytosis (GO:0017156)4.42919991
38spermatid nucleus differentiation (GO:0007289)4.42260134
39gene silencing by RNA (GO:0031047)4.35996488
40regulation of microtubule-based movement (GO:0060632)4.28457032
41multicellular organismal reproductive process (GO:0048609)4.27754272
42microtubule severing (GO:0051013)4.26464070
43monoubiquitinated protein deubiquitination (GO:0035520)4.24346823
44genitalia morphogenesis (GO:0035112)4.20912152
45protein localization to cilium (GO:0061512)4.10699141
46meiotic cell cycle process (GO:1903046)3.96748378
47left/right pattern formation (GO:0060972)3.90418941
48synapsis (GO:0007129)3.81367226
49chaperone-mediated protein complex assembly (GO:0051131)3.75671036
50intraciliary transport (GO:0042073)3.61508702
51nuclear pore complex assembly (GO:0051292)3.56309363
52glycerol ether metabolic process (GO:0006662)3.52252413
53chromosome condensation (GO:0030261)3.48720056
54DNA packaging (GO:0006323)3.43362298
55multicellular organismal development (GO:0007275)3.42028359
56single strand break repair (GO:0000012)3.37711443
57regulation of centriole replication (GO:0046599)3.33330055
58ether metabolic process (GO:0018904)3.26635698
59protein polyglutamylation (GO:0018095)3.25031904
60negative regulation of organelle assembly (GO:1902116)3.21410318
61gene silencing (GO:0016458)3.18667153
62axoneme assembly (GO:0035082)3.18607995
63protein refolding (GO:0042026)3.16736435
64protein K11-linked deubiquitination (GO:0035871)3.14163177
65microtubule-based movement (GO:0007018)3.09040260
66regulation of spindle checkpoint (GO:0090231)3.08191997
67centriole replication (GO:0007099)3.07389123
68DNA methylation (GO:0006306)3.05481709
69DNA alkylation (GO:0006305)3.05481709
70lactate metabolic process (GO:0006089)3.02938795
71mitotic sister chromatid cohesion (GO:0007064)3.00931647
72nucleus organization (GO:0006997)2.98465527
73cilium organization (GO:0044782)2.97400594
74centriole assembly (GO:0098534)2.94674206
75amino-acid betaine transport (GO:0015838)2.94265599
76carnitine transport (GO:0015879)2.94265599
77carnitine transmembrane transport (GO:1902603)2.92024826
78regulation of protein polyubiquitination (GO:1902914)2.91862564
79nuclear pore organization (GO:0006999)2.91524770
80sister chromatid cohesion (GO:0007062)2.90106744
81histone exchange (GO:0043486)2.89471692
82sexual reproduction (GO:0019953)2.88041818
83microtubule polymerization or depolymerization (GO:0031109)2.84036699
84alditol metabolic process (GO:0019400)2.82813049
85cilium assembly (GO:0042384)2.81012372
86polyol catabolic process (GO:0046174)2.78863673
87negative regulation of DNA repair (GO:0045738)2.77280079
88pore complex assembly (GO:0046931)2.74144902
89cellular component assembly involved in morphogenesis (GO:0010927)2.71895747
90cilium morphogenesis (GO:0060271)2.68739616
91cilium or flagellum-dependent cell motility (GO:0001539)12.9937345
92fusion of sperm to egg plasma membrane (GO:0007342)12.8819496
93sperm motility (GO:0030317)11.7860989
94piRNA metabolic process (GO:0034587)11.4099152
95acrosome assembly (GO:0001675)10.7206881
96sperm-egg recognition (GO:0035036)10.5548455
97multicellular organism reproduction (GO:0032504)10.4080826
98axonemal dynein complex assembly (GO:0070286)10.2912785
99cell wall macromolecule metabolic process (GO:0044036)10.1631131
100cell wall macromolecule catabolic process (GO:0016998)10.1631131

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.84655408
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.36864160
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.72285522
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50323209
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.44057785
6* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.40732311
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32505543
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.31779738
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.11797592
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05094473
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.02878810
12ZNF274_21170338_ChIP-Seq_K562_Hela2.01363140
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.8476881
14EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.94307575
15STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88998828
16ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80752832
17VDR_22108803_ChIP-Seq_LS180_Human1.78129979
18KAP1_22055183_ChIP-Seq_ESCs_Mouse1.72039017
19KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.68804550
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64592181
21* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.62693434
22TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.59902611
23STAT1_17558387_ChIP-Seq_HELA_Human1.56833244
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.52022472
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49824905
26WDR5_24793694_ChIP-Seq_LNCAP_Human1.48839851
27GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.47768836
28FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47145460
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.43876015
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41479778
31* TAL1_26923725_Chip-Seq_HPCs_Mouse1.35674214
32SOX2_22085726_ChIP-Seq_NPCs_Mouse1.35509942
33GATA3_21867929_ChIP-Seq_CD8_Mouse1.34867577
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34748330
35MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32488947
36* KDM2B_26808549_Chip-Seq_REH_Human1.28534576
37CBP_20019798_ChIP-Seq_JUKART_Human1.25289296
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25289296
39* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24879591
40GATA3_21867929_ChIP-Seq_TH1_Mouse1.20571888
41SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.18161925
42LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.17917175
43SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16788265
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16051474
45RNF2_27304074_Chip-Seq_NSC_Mouse1.15301537
46CRX_20693478_ChIP-Seq_RETINA_Mouse1.15148136
47FLI1_21867929_ChIP-Seq_TH2_Mouse1.12506351
48OCT4_18555785_Chip-Seq_ESCs_Mouse1.11961486
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10972985
50RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10581375
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10288236
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10288236
53REST_21632747_ChIP-Seq_MESCs_Mouse1.09512210
54P53_21459846_ChIP-Seq_SAOS-2_Human1.08791073
55FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07955673
56* NANOG_18555785_Chip-Seq_ESCs_Mouse1.07079522
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06978452
58CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06624258
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06546461
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05323049
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04329874
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.04180757
63* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03698491
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02772312
65KLF4_18555785_Chip-Seq_ESCs_Mouse1.00543941
66OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99835433
67CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99692989
68SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97390026
69* P300_18555785_Chip-Seq_ESCs_Mouse0.96919792
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96886459
71* P53_22387025_ChIP-Seq_ESCs_Mouse0.96737253
72ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96422502
73ESET_19884257_ChIP-Seq_ESCs_Mouse0.96145386
74EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95601767
75PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95581237
76SPI1_26923725_Chip-Seq_HPCs_Mouse0.94481702
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93447666
78YY1_22570637_ChIP-Seq_MALME-3M_Human0.93250716
79CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93009789
80* CMYC_18555785_Chip-Seq_ESCs_Mouse0.92805867
81* GF1_26923725_Chip-Seq_HPCs_Mouse0.92412577
82RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91922016
83ERG_20517297_ChIP-Seq_VCAP_Human0.91835628
84* STAT3_18555785_Chip-Seq_ESCs_Mouse0.91789111
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90466343
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90103609
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89824307
88SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89032861
89RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87712582
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86810580
91NFYB_21822215_ChIP-Seq_K562_Human0.85484530
92PU1_27457419_Chip-Seq_LIVER_Mouse0.85367939
93* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85358953
94LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84541164
95SOX2_21211035_ChIP-Seq_LN229_Human0.84198003
96FLI1_21867929_ChIP-Seq_CD8_Mouse0.84123778
97RARA_24833708_ChIP-Seq_LIVER_Mouse0.82825799
98NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82550159
99SOX9_26525672_Chip-Seq_HEART_Mouse0.82456077
100CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82391348

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.45390925
2MP0003698_abnormal_male_reproductive5.99468436
3MP0001929_abnormal_gametogenesis5.72611247
4MP0002210_abnormal_sex_determination4.21219776
5MP0001145_abnormal_male_reproductive3.50898654
6MP0002161_abnormal_fertility/fecundity3.30801272
7MP0000653_abnormal_sex_gland3.07855390
8MP0002653_abnormal_ependyma_morphology2.97704780
9MP0008057_abnormal_DNA_replication2.57140895
10MP0005410_abnormal_fertilization14.2255611
11MP0002160_abnormal_reproductive_system1.93831091
12MP0008058_abnormal_DNA_repair1.80252625
13MP0010094_abnormal_chromosome_stability1.78065960
14MP0005670_abnormal_white_adipose1.67528627
15MP0005623_abnormal_meninges_morphology1.64954871
16MP0008995_early_reproductive_senescence1.64085299
17MP0003786_premature_aging1.41947787
18MP0003646_muscle_fatigue1.36909354
19MP0005647_abnormal_sex_gland1.27654215
20MP0002282_abnormal_trachea_morphology1.19056840
21MP0004233_abnormal_muscle_weight1.13541148
22MP0008007_abnormal_cellular_replicative1.12748617
23MP0003111_abnormal_nucleus_morphology1.04627987
24MP0009046_muscle_twitch1.03376492
25MP0005389_reproductive_system_phenotype1.01498334
26MP0005377_hearing/vestibular/ear_phenot0.92630016
27MP0003878_abnormal_ear_physiology0.92630016
28MP0001984_abnormal_olfaction0.90664925
29MP0001765_abnormal_ion_homeostasis0.85107002
30MP0003011_delayed_dark_adaptation0.79297014
31MP0003077_abnormal_cell_cycle0.74628452
32MP0003699_abnormal_female_reproductive0.72783982
33MP0010307_abnormal_tumor_latency0.72334285
34MP0001119_abnormal_female_reproductive0.71575822
35MP0000569_abnormal_digit_pigmentation0.66106887
36MP0000358_abnormal_cell_content/0.65859175
37MP0001730_embryonic_growth_arrest0.62103265
38MP0002102_abnormal_ear_morphology0.59318710
39MP0004808_abnormal_hematopoietic_stem0.58393964
40MP0003115_abnormal_respiratory_system0.56635535
41MP0004134_abnormal_chest_morphology0.55440688
42MP0001545_abnormal_hematopoietic_system0.53312814
43MP0005397_hematopoietic_system_phenotyp0.53312814
44MP0001293_anophthalmia0.53149578
45MP0001727_abnormal_embryo_implantation0.51611937
46MP0003950_abnormal_plasma_membrane0.51501200
47MP0003693_abnormal_embryo_hatching0.50729771
48MP0009278_abnormal_bone_marrow0.50588536
49MP0002234_abnormal_pharynx_morphology0.50507383
50MP0004957_abnormal_blastocyst_morpholog0.43706508
51MP0000427_abnormal_hair_cycle0.42782546
52MP0002084_abnormal_developmental_patter0.41882168
53MP0000313_abnormal_cell_death0.40976226
54MP0002269_muscular_atrophy0.38829530
55MP0001661_extended_life_span0.38275935
56MP0005253_abnormal_eye_physiology0.37894061
57MP0005380_embryogenesis_phenotype0.37229759
58MP0001672_abnormal_embryogenesis/_devel0.37229759
59MP0005666_abnormal_adipose_tissue0.36464314
60MP0005636_abnormal_mineral_homeostasis0.36439754
61MP0005391_vision/eye_phenotype0.36055036
62MP0002928_abnormal_bile_duct0.35408658
63MP0005551_abnormal_eye_electrophysiolog0.33718297
64MP0001324_abnormal_eye_pigmentation0.33316652
65MP0001697_abnormal_embryo_size0.33193323
66MP0004036_abnormal_muscle_relaxation0.33070046
67MP0003861_abnormal_nervous_system0.32918285
68MP0004019_abnormal_vitamin_homeostasis0.32831068
69MP0008932_abnormal_embryonic_tissue0.31080025
70MP0002971_abnormal_brown_adipose0.29263923
71MP0006036_abnormal_mitochondrial_physio0.28961046
72MP0002085_abnormal_embryonic_tissue0.28223629
73MP0003936_abnormal_reproductive_system0.28140162
74MP0003879_abnormal_hair_cell0.27604459
75MP0009115_abnormal_fat_cell0.27443726
76MP0003718_maternal_effect0.27141107
77MP0004197_abnormal_fetal_growth/weight/0.26869969
78MP0001764_abnormal_homeostasis0.26777924
79MP0002092_abnormal_eye_morphology0.26630335
80MP0002080_prenatal_lethality0.26513793
81MP0003984_embryonic_growth_retardation0.26396513
82MP0006072_abnormal_retinal_apoptosis0.25152805
83MP0006035_abnormal_mitochondrial_morpho0.24715826
84MP0002088_abnormal_embryonic_growth/wei0.24171086
85MP0002152_abnormal_brain_morphology0.23909102
86MP0004133_heterotaxia0.23426942
87MP0000647_abnormal_sebaceous_gland0.22500102
88MP0003329_amyloid_beta_deposits0.18993023
89MP0003315_abnormal_perineum_morphology0.18975674
90MP0004811_abnormal_neuron_physiology0.18700293
91MP0003890_abnormal_embryonic-extraembry0.18626268
92MP0002132_abnormal_respiratory_system0.17430093
93MP0009672_abnormal_birth_weight0.17350084
94MP0000350_abnormal_cell_proliferation0.17183890
95MP0002169_no_abnormal_phenotype0.16711633
96MP0003045_fibrosis0.16693242
97MP0000432_abnormal_head_morphology0.16534566
98MP0002873_normal_phenotype0.16446372
99MP0002970_abnormal_white_adipose0.15879492
100MP0005076_abnormal_cell_differentiation0.15567969

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.17642259
2Abnormal respiratory epithelium morphology (HP:0012253)8.74625189
3Abnormal respiratory motile cilium morphology (HP:0005938)8.74625189
4Rhinitis (HP:0012384)7.77107138
5Chronic bronchitis (HP:0004469)7.34033552
6Abnormal ciliary motility (HP:0012262)7.30060645
7Infertility (HP:0000789)6.20949066
8Nasal polyposis (HP:0100582)6.07967050
9Abnormality of the nasal mucosa (HP:0000433)4.95733501
10Nephronophthisis (HP:0000090)4.56866008
11Bronchiectasis (HP:0002110)4.46050072
12Bronchitis (HP:0012387)4.31412599
13Abnormality of the lower motor neuron (HP:0002366)3.92659449
14Male infertility (HP:0003251)3.70548976
15Abnormality of the renal medulla (HP:0100957)3.47091415
16Abnormal spermatogenesis (HP:0008669)3.45505534
17Gonadotropin excess (HP:0000837)3.44314596
18Recurrent sinusitis (HP:0011108)3.17571951
19Recurrent otitis media (HP:0000403)3.15766925
20Tubulointerstitial nephritis (HP:0001970)3.12549213
21Amyotrophic lateral sclerosis (HP:0007354)2.95033033
22Azoospermia (HP:0000027)2.85737236
23Fibular hypoplasia (HP:0003038)2.82788196
24Molar tooth sign on MRI (HP:0002419)2.74353502
25Abnormality of midbrain morphology (HP:0002418)2.74353502
26Medial flaring of the eyebrow (HP:0010747)2.72112715
27Tubular atrophy (HP:0000092)2.65791893
28Impulsivity (HP:0100710)2.51403046
29Tubulointerstitial abnormality (HP:0001969)2.46546857
30Recurrent bronchitis (HP:0002837)2.29665297
31Upper motor neuron abnormality (HP:0002127)2.25626434
32Postaxial foot polydactyly (HP:0001830)2.18937680
33Impaired proprioception (HP:0010831)2.16623047
34Abnormality of the anterior horn cell (HP:0006802)2.13043808
35Degeneration of anterior horn cells (HP:0002398)2.13043808
36Stage 5 chronic kidney disease (HP:0003774)2.06920481
3711 pairs of ribs (HP:0000878)2.00540699
38Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2156980
39Dynein arm defect of respiratory motile cilia (HP:0012255)12.5199729
40Absent/shortened dynein arms (HP:0200106)12.5199729
41Supernumerary spleens (HP:0009799)1.92866318
42Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91838784
43Short ribs (HP:0000773)1.89964614
44Oculomotor apraxia (HP:0000657)1.89300156
45Congenital hepatic fibrosis (HP:0002612)1.88748998
46Abnormality of dentin (HP:0010299)1.83628277
47Aplasia/Hypoplasia of the fibula (HP:0006492)1.82391345
48Abnormality of the renal cortex (HP:0011035)1.81538003
49Tubulointerstitial fibrosis (HP:0005576)1.80757296
50Facial cleft (HP:0002006)1.75335851
51Heterotopia (HP:0002282)1.74053597
52Abnormality of the dental root (HP:0006486)1.74033245
53Taurodontia (HP:0000679)1.74033245
54Abnormality of permanent molar morphology (HP:0011071)1.74033245
55Renal dysplasia (HP:0000110)1.72656243
56Microglossia (HP:0000171)1.70854571
57Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.70073397
58Abnormal drinking behavior (HP:0030082)1.68202388
59Polydipsia (HP:0001959)1.68202388
60Postaxial hand polydactyly (HP:0001162)1.67079600
61Chronic sinusitis (HP:0011109)1.66983767
62Abnormality of the dental pulp (HP:0006479)1.64183280
63Abnormality of molar morphology (HP:0011070)1.63414715
64Abnormality of molar (HP:0011077)1.63414715
65Selective tooth agenesis (HP:0001592)1.60490952
66Congenital primary aphakia (HP:0007707)1.59010183
67Median cleft lip (HP:0000161)1.58931993
68Absent frontal sinuses (HP:0002688)1.58293847
69Gait imbalance (HP:0002141)1.57478105
70Spastic tetraparesis (HP:0001285)1.52529901
71Bell-shaped thorax (HP:0001591)1.49103136
72Absent epiphyses (HP:0010577)1.48859723
73Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.48859723
74Breast carcinoma (HP:0003002)1.48460480
75Abnormality of ocular smooth pursuit (HP:0000617)1.46489674
76Short thorax (HP:0010306)1.46068170
77Cystic liver disease (HP:0006706)1.45224482
78Abnormality of renal excretion (HP:0011036)1.44556820
79Aplasia/Hypoplasia of the tongue (HP:0010295)1.43059002
80Cholecystitis (HP:0001082)1.41182248
81Abnormal gallbladder physiology (HP:0012438)1.41182248
82J-shaped sella turcica (HP:0002680)1.40717820
83Pancreatic fibrosis (HP:0100732)1.38974158
84Nephrogenic diabetes insipidus (HP:0009806)1.35894599
85Conjunctival telangiectasia (HP:0000524)1.34924235
86Abnormal biliary tract physiology (HP:0012439)1.32992319
87Bile duct proliferation (HP:0001408)1.32992319
88Broad distal phalanx of finger (HP:0009836)1.30541727
89Aplasia/Hypoplasia of the lens (HP:0008063)1.28857345
90Dyschromatopsia (HP:0007641)1.28742994
91Sloping forehead (HP:0000340)1.27267282
92Poor coordination (HP:0002370)1.27042209
93Nephropathy (HP:0000112)1.26515747
94Large eyes (HP:0001090)1.26284725
95Gaze-evoked nystagmus (HP:0000640)1.24772752
96Decreased motor nerve conduction velocity (HP:0003431)1.24147336
97Hypoplasia of dental enamel (HP:0006297)1.22329201
98Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.21711583
99Nephroblastoma (Wilms tumor) (HP:0002667)1.20483288
100Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.20343274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK16.88811853
2PRKD35.98954976
3ICK5.41348113
4PNCK4.40970049
5PTK2B3.95120877
6WNK43.72995460
7NEK23.65701466
8STK393.50392893
9CDC72.51909813
10STK382.21722539
11WEE11.90865075
12TYRO31.87021337
13STK31.86236600
14WNK11.84493881
15MAPK151.69361776
16TTK1.69039447
17PASK1.66813739
18CCNB11.64931046
19DYRK1B1.61412527
20DYRK31.43693186
21CDK121.43171226
22PLK41.38775520
23CHEK21.33519971
24ATR1.29395619
25CHEK11.29045391
26PINK11.16058768
27IRAK11.10839016
28LMTK21.06859105
29PLK10.97411002
30ATM0.92487304
31STK38L0.92292696
32CAMK1G0.86084072
33MTOR0.76419824
34WNK30.73567697
35EEF2K0.69282287
36NTRK20.66821761
37PAK10.62576922
38PDPK10.61765179
39MAP2K60.61284904
40BUB10.60710434
41TESK20.59222736
42BRSK20.57753745
43MUSK0.57404417
44PRKAA10.55068040
45BMPR1B0.54583676
46BRAF0.51544481
47* PDK10.49492533
48PRKCG0.49060172
49RPS6KB10.45150581
50PAK20.44772769
51NEK60.44121502
52CDK20.41671980
53CDK10.39905658
54MAP3K40.39129319
55IRAK20.37249210
56SRPK10.35584182
57CDK40.34656635
58CSNK1D0.31957589
59CSNK2A10.31901982
60CAMKK10.30654135
61GSK3B0.29938191
62MARK30.27440964
63CDK70.26898590
64AURKB0.26569528
65CSNK2A20.26365019
66PRKDC0.25701185
67BRSK10.24689583
68STK100.24659794
69AURKA0.23763882
70MAPK80.23357962
71PRKACB0.22756550
72MARK20.22431488
73EIF2AK10.21919814
74YES10.21296986
75MAPK100.21114767
76STK110.19142408
77CDK60.18264655
78CSNK1E0.17866393
79MAPKAPK50.17814643
80PRKG10.17752303
81PAK40.17521840
82PRKCZ0.16823951
83PDGFRB0.16706445
84RIPK40.16259761
85RPS6KA10.15924869
86ACVR1B0.15772203
87PRKACG0.15560738
88CDK30.15014975
89RPS6KA30.14964108
90EGFR0.14817542
91TAOK10.14016602
92CDK150.13290254
93MAPK10.13044826
94PRKCB0.12329126
95MAP3K50.11895561
96MAP3K100.10230487
97ZAP700.10124606
98CDK180.09688873
99MAPK140.09260269
100LATS10.08851643

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.32601055
2Basal transcription factors_Homo sapiens_hsa030223.48168141
3* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.26175599
4Propanoate metabolism_Homo sapiens_hsa006403.13427608
5Fatty acid biosynthesis_Homo sapiens_hsa000613.12764301
6Fanconi anemia pathway_Homo sapiens_hsa034603.09418195
7Dorso-ventral axis formation_Homo sapiens_hsa043202.91047141
8Selenocompound metabolism_Homo sapiens_hsa004502.84837456
9* Pyruvate metabolism_Homo sapiens_hsa006202.76565744
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.61935374
11Linoleic acid metabolism_Homo sapiens_hsa005912.56637543
12Pentose phosphate pathway_Homo sapiens_hsa000302.54322759
13Oocyte meiosis_Homo sapiens_hsa041142.47314975
14* Glucagon signaling pathway_Homo sapiens_hsa049222.18706170
15RNA transport_Homo sapiens_hsa030132.02785423
16Glycerolipid metabolism_Homo sapiens_hsa005611.95861483
17mRNA surveillance pathway_Homo sapiens_hsa030151.85997997
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.84451513
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.82183637
20Huntingtons disease_Homo sapiens_hsa050161.62387773
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.52977612
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.52792526
23Antigen processing and presentation_Homo sapiens_hsa046121.50667040
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.50003758
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48021540
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47773513
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.43325212
28PPAR signaling pathway_Homo sapiens_hsa033201.38100817
29Amphetamine addiction_Homo sapiens_hsa050311.35776754
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31400527
31Fructose and mannose metabolism_Homo sapiens_hsa000511.28641159
32Homologous recombination_Homo sapiens_hsa034401.24921322
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20767715
34Purine metabolism_Homo sapiens_hsa002301.18955728
35Ether lipid metabolism_Homo sapiens_hsa005651.14673317
36Renin secretion_Homo sapiens_hsa049241.09731222
37Biosynthesis of amino acids_Homo sapiens_hsa012301.08261471
38Fat digestion and absorption_Homo sapiens_hsa049751.04963924
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03741706
40Cardiac muscle contraction_Homo sapiens_hsa042601.01125663
41Mineral absorption_Homo sapiens_hsa049780.97240549
42Cell cycle_Homo sapiens_hsa041100.96441207
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88972900
44* Carbon metabolism_Homo sapiens_hsa012000.88913491
45Fatty acid metabolism_Homo sapiens_hsa012120.84109724
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73405635
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73099486
48Estrogen signaling pathway_Homo sapiens_hsa049150.72564025
49RNA degradation_Homo sapiens_hsa030180.71878737
50ABC transporters_Homo sapiens_hsa020100.70667501
51Long-term potentiation_Homo sapiens_hsa047200.69542423
52Glutathione metabolism_Homo sapiens_hsa004800.67429315
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67325589
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64988481
55Fatty acid degradation_Homo sapiens_hsa000710.63845822
56Systemic lupus erythematosus_Homo sapiens_hsa053220.63431810
57Legionellosis_Homo sapiens_hsa051340.62623518
58Inositol phosphate metabolism_Homo sapiens_hsa005620.61011833
59Pyrimidine metabolism_Homo sapiens_hsa002400.59898418
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58991338
61Arachidonic acid metabolism_Homo sapiens_hsa005900.58076407
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57575293
63Spliceosome_Homo sapiens_hsa030400.57032817
64Hedgehog signaling pathway_Homo sapiens_hsa043400.53519851
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51603148
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51376461
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49372937
68Calcium signaling pathway_Homo sapiens_hsa040200.49173535
69Chemical carcinogenesis_Homo sapiens_hsa052040.48452901
70AMPK signaling pathway_Homo sapiens_hsa041520.47097238
71Nucleotide excision repair_Homo sapiens_hsa034200.46368599
72Proteasome_Homo sapiens_hsa030500.44981101
73VEGF signaling pathway_Homo sapiens_hsa043700.44371229
74Collecting duct acid secretion_Homo sapiens_hsa049660.43995229
75DNA replication_Homo sapiens_hsa030300.43780922
76N-Glycan biosynthesis_Homo sapiens_hsa005100.41290231
77Base excision repair_Homo sapiens_hsa034100.38561631
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.38136163
79Endocytosis_Homo sapiens_hsa041440.35743013
80* Metabolic pathways_Homo sapiens_hsa011000.34302698
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34138220
82Renin-angiotensin system_Homo sapiens_hsa046140.33584571
83p53 signaling pathway_Homo sapiens_hsa041150.29499474
84Non-homologous end-joining_Homo sapiens_hsa034500.29156278
85Viral carcinogenesis_Homo sapiens_hsa052030.28857555
86Epstein-Barr virus infection_Homo sapiens_hsa051690.28201155
87Thyroid hormone synthesis_Homo sapiens_hsa049180.28159676
88Protein digestion and absorption_Homo sapiens_hsa049740.26010309
89Taste transduction_Homo sapiens_hsa047420.25334458
90Mismatch repair_Homo sapiens_hsa034300.25306726
91Wnt signaling pathway_Homo sapiens_hsa043100.24067311
92Sphingolipid metabolism_Homo sapiens_hsa006000.23757967
93Bile secretion_Homo sapiens_hsa049760.23427530
94Alcoholism_Homo sapiens_hsa050340.21780975
95Insulin secretion_Homo sapiens_hsa049110.21072356
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.20764225
97Retinol metabolism_Homo sapiens_hsa008300.18738560
98Synaptic vesicle cycle_Homo sapiens_hsa047210.16011886
99Pancreatic secretion_Homo sapiens_hsa049720.15863698
100Influenza A_Homo sapiens_hsa051640.13893140

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