PDIA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.50178535
2COPII vesicle coating (GO:0048208)6.07157522
3retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.69621182
4activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.58104860
5positive regulation of nuclease activity (GO:0032075)5.45605558
6signal peptide processing (GO:0006465)5.21833678
7sequestering of metal ion (GO:0051238)5.09760308
8* protein retention in ER lumen (GO:0006621)5.09307527
9regulation of nuclease activity (GO:0032069)5.00966730
10endoplasmic reticulum unfolded protein response (GO:0030968)4.92167237
11protein maturation by protein folding (GO:0022417)4.85513170
12cellular response to unfolded protein (GO:0034620)4.76204802
13vesicle coating (GO:0006901)4.57914504
14cellular response to topologically incorrect protein (GO:0035967)4.55927774
15ER-nucleus signaling pathway (GO:0006984)4.51983411
16ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.20156873
17hemidesmosome assembly (GO:0031581)4.10068932
18* response to endoplasmic reticulum stress (GO:0034976)3.80546886
19exocrine pancreas development (GO:0031017)3.76539014
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.73953477
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.73953477
22cellular response to vitamin D (GO:0071305)3.73049332
23* protein N-linked glycosylation via asparagine (GO:0018279)3.69472506
24* peptidyl-asparagine modification (GO:0018196)3.68410827
25response to unfolded protein (GO:0006986)3.67243723
26desmosome organization (GO:0002934)3.61884679
274-hydroxyproline metabolic process (GO:0019471)3.59374113
28peptide catabolic process (GO:0043171)3.58755485
29response to topologically incorrect protein (GO:0035966)3.55305073
30peptide hormone processing (GO:0016486)3.44043290
31pinocytosis (GO:0006907)3.38875084
32* protein N-linked glycosylation (GO:0006487)3.36007368
33UDP-N-acetylglucosamine metabolic process (GO:0006047)3.34210570
34apoptotic cell clearance (GO:0043277)3.32035897
35folic acid-containing compound biosynthetic process (GO:0009396)3.31935441
36endocrine pancreas development (GO:0031018)3.30369586
37antigen processing and presentation of endogenous antigen (GO:0019883)3.27807716
38ER to Golgi vesicle-mediated transport (GO:0006888)3.22782527
39nuclear pore complex assembly (GO:0051292)3.22354516
40regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.20730979
41protein localization to endosome (GO:0036010)3.15918781
42ER overload response (GO:0006983)3.13854258
43cellular response to vitamin (GO:0071295)3.13354769
44protein autoprocessing (GO:0016540)3.08660655
45DNA unwinding involved in DNA replication (GO:0006268)3.05341475
46negative regulation of glycoprotein biosynthetic process (GO:0010561)3.03090428
47type B pancreatic cell development (GO:0003323)2.99417142
48cell-substrate junction assembly (GO:0007044)2.97523030
49keratan sulfate catabolic process (GO:0042340)2.94030959
50membrane protein ectodomain proteolysis (GO:0006509)2.92389819
51bundle of His cell to Purkinje myocyte communication (GO:0086069)2.91132467
52establishment of integrated proviral latency (GO:0075713)2.89927165
53regulation of type B pancreatic cell apoptotic process (GO:2000674)2.89085628
54regulation of translational fidelity (GO:0006450)2.86955934
55hyaluronan catabolic process (GO:0030214)2.85242212
56glandular epithelial cell development (GO:0002068)2.80818873
57barbed-end actin filament capping (GO:0051016)2.79494502
58planar cell polarity pathway involved in neural tube closure (GO:0090179)2.76819883
59regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.75912238
60epithelial cell-cell adhesion (GO:0090136)2.72837446
61glucose catabolic process (GO:0006007)2.72408886
62Golgi organization (GO:0007030)2.71878603
63maternal placenta development (GO:0001893)2.70777453
64glandular epithelial cell differentiation (GO:0002067)2.66503697
65skin morphogenesis (GO:0043589)2.65732391
66chaperone-mediated protein folding (GO:0061077)2.65534804
67proline metabolic process (GO:0006560)2.62592097
68collagen fibril organization (GO:0030199)2.61975011
69surfactant homeostasis (GO:0043129)2.61229860
70nuclear pore organization (GO:0006999)2.60844289
71regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.60709356
72positive regulation of glycoprotein metabolic process (GO:1903020)2.59285915
73gap junction assembly (GO:0016264)2.58691357
74branching involved in mammary gland duct morphogenesis (GO:0060444)2.58411974
75regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.58268487
76L-alpha-amino acid transmembrane transport (GO:1902475)2.56254248
77toxin metabolic process (GO:0009404)2.55998509
78collagen metabolic process (GO:0032963)2.55599673
79glucocorticoid receptor signaling pathway (GO:0042921)2.55187249
80regulation of translational termination (GO:0006449)2.55162101
81negative regulation of fatty acid transport (GO:2000192)2.54419773
82extracellular matrix disassembly (GO:0022617)2.53722262
83peptidyl-proline hydroxylation (GO:0019511)2.53604076
84endothelial cell morphogenesis (GO:0001886)2.52304120
85glucose 6-phosphate metabolic process (GO:0051156)2.52014689
86dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.51896335
87positive regulation of receptor biosynthetic process (GO:0010870)2.51382134
88multicellular organismal macromolecule metabolic process (GO:0044259)2.50540914
89very-low-density lipoprotein particle assembly (GO:0034379)2.50240454
90wound healing, spreading of epidermal cells (GO:0035313)2.49830320
91positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.48814953
92GDP-mannose metabolic process (GO:0019673)2.48741192
93negative regulation of glycoprotein metabolic process (GO:1903019)2.48156150
94adherens junction assembly (GO:0034333)2.48077002
95pore complex assembly (GO:0046931)2.47865837
96cellular copper ion homeostasis (GO:0006878)2.47756194
97cellular zinc ion homeostasis (GO:0006882)2.47097974
98chondrocyte proliferation (GO:0035988)2.45944945
99nucleobase-containing small molecule interconversion (GO:0015949)2.45418599
100mesodermal cell differentiation (GO:0048333)2.45317312
101nucleotide-sugar biosynthetic process (GO:0009226)2.44671375
102cell adhesion mediated by integrin (GO:0033627)2.44420739
103regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.43476013
104cellular response to nutrient (GO:0031670)2.43442219
105collagen catabolic process (GO:0030574)2.41339035
106negative regulation of chondrocyte differentiation (GO:0032331)2.40114917
107establishment of viral latency (GO:0019043)2.39572285
108regulation of metalloenzyme activity (GO:0048552)2.37206673
109epithelial cell differentiation involved in prostate gland development (GO:0060742)2.36716003
110negative regulation of fibrinolysis (GO:0051918)2.35488437
111protein export from nucleus (GO:0006611)2.35130811
112embryonic process involved in female pregnancy (GO:0060136)2.34341711
113regulation of extracellular matrix disassembly (GO:0010715)2.34062052
114multicellular organismal metabolic process (GO:0044236)2.33673778
115cellular response to ATP (GO:0071318)2.33508050
116basement membrane organization (GO:0071711)2.32639595
117columnar/cuboidal epithelial cell development (GO:0002066)2.32639186
118tricarboxylic acid metabolic process (GO:0072350)2.32416596
119cell-substrate adherens junction assembly (GO:0007045)2.31728145
120focal adhesion assembly (GO:0048041)2.31728145
121cytoskeletal anchoring at plasma membrane (GO:0007016)2.31639087
122Arp2/3 complex-mediated actin nucleation (GO:0034314)2.31581259
123thyroid hormone generation (GO:0006590)2.30929719
124regulation of apoptotic cell clearance (GO:2000425)2.30482254
125protein hydroxylation (GO:0018126)2.30435683
126regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.30397128
127protein carboxylation (GO:0018214)2.30281612
128peptidyl-glutamic acid carboxylation (GO:0017187)2.30281612
129negative regulation of cell fate specification (GO:0009996)2.29224129
130pentose-phosphate shunt (GO:0006098)2.28971849
131multicellular organismal catabolic process (GO:0044243)2.28617595
132hormone catabolic process (GO:0042447)2.28051964
133pteridine-containing compound biosynthetic process (GO:0042559)2.27648954
134proline biosynthetic process (GO:0006561)2.27226891
135hypotonic response (GO:0006971)2.26901137
136positive regulation of hormone biosynthetic process (GO:0046886)2.26687543
137wound healing, spreading of cells (GO:0044319)2.26277844
138chaperone mediated protein folding requiring cofactor (GO:0051085)2.24140386
139antigen processing and presentation via MHC class Ib (GO:0002475)2.21084320
140endodermal cell differentiation (GO:0035987)2.19595226
141nucleotide-sugar metabolic process (GO:0009225)2.17976993
142misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.17877782
143cellular response to antibiotic (GO:0071236)2.14778240
144* cell redox homeostasis (GO:0045454)2.14211446
145mannose metabolic process (GO:0006013)2.12617579
146polarized epithelial cell differentiation (GO:0030859)2.10293971
147Golgi vesicle transport (GO:0048193)2.09940690
148lipopolysaccharide biosynthetic process (GO:0009103)2.09784031
149membrane budding (GO:0006900)2.09244327
150gland morphogenesis (GO:0022612)2.07906247
151NADPH regeneration (GO:0006740)2.06254171
152localization within membrane (GO:0051668)2.05118832
153histone-serine phosphorylation (GO:0035404)2.04504230
154decidualization (GO:0046697)2.03992879
155valine metabolic process (GO:0006573)2.03352212
156maternal process involved in female pregnancy (GO:0060135)2.02644115
157positive regulation of endothelial cell apoptotic process (GO:2000353)2.01526885
158COPI coating of Golgi vesicle (GO:0048205)10.6497613
159Golgi transport vesicle coating (GO:0048200)10.6497613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.80106558
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.67686258
3CLOCK_20551151_ChIP-Seq_293T_Human3.26914537
4E2F7_22180533_ChIP-Seq_HELA_Human2.92801800
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.85682145
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.81029339
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.58746739
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55547894
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45315364
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.21445059
11GATA1_22025678_ChIP-Seq_K562_Human2.12665351
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.05731810
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.04344902
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.03504592
15MYC_22102868_ChIP-Seq_BL_Human2.02975144
16RXR_22158963_ChIP-Seq_LIVER_Mouse1.99137442
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93270080
18AR_21909140_ChIP-Seq_LNCAP_Human1.85566647
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75937852
20SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.75550460
21TFEB_21752829_ChIP-Seq_HELA_Human1.68527549
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68489038
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66870159
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64312180
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.64029248
26* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63393615
27DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.60322521
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60215049
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59278007
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.58995530
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.56991686
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54778314
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54640154
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53989512
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53115845
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51527108
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.51085791
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50084766
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48516010
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47551610
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47297687
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47061763
43LXR_22158963_ChIP-Seq_LIVER_Mouse1.45596151
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45134766
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43454537
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41586078
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39663921
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38557726
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38279906
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36135991
51* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.33715234
52LXR_22292898_ChIP-Seq_THP-1_Human1.33032287
53ATF3_27146783_Chip-Seq_COLON_Human1.32986189
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32796002
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.32787671
56TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32265651
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31804333
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30299550
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27557506
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26645780
61CHD1_26751641_Chip-Seq_LNCaP_Human1.26102831
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25579121
63NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.25018065
64* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.24444616
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23113003
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22577802
67* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22453865
68* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22361861
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22283601
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22249338
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21418047
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21405544
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19588270
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19432861
75VDR_21846776_ChIP-Seq_THP-1_Human1.19303302
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18031174
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17486289
78* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16055533
79BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16004208
80GATA6_25053715_ChIP-Seq_YYC3_Human1.15844180
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.14166654
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14157114
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12983493
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12938552
85GABP_17652178_ChIP-ChIP_JURKAT_Human1.12646880
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11193705
87CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10917452
88RACK7_27058665_Chip-Seq_MCF-7_Human1.09815951
89* GATA4_25053715_ChIP-Seq_YYC3_Human1.09461397
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09418520
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09335316
92GABP_19822575_ChIP-Seq_HepG2_Human1.09333545
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08984176
94SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08627027
95ZNF263_19887448_ChIP-Seq_K562_Human1.08546521
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08534722
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08534722
98* SOX2_20726797_ChIP-Seq_SW620_Human1.08003859
99NCOR1_26117541_ChIP-Seq_K562_Human1.07020335
100ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07016326
101EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06918539
102MYB_26560356_Chip-Seq_TH2_Human1.06498279
103ESR2_21235772_ChIP-Seq_MCF-7_Human1.06266761
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04989072
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04685113
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04220715
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04163169
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03773872
109ELK1_19687146_ChIP-ChIP_HELA_Human1.03617068
110UBF1/2_26484160_Chip-Seq_HMECs_Human1.03263118
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03200510
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02006414
113* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01459558
114XRN2_22483619_ChIP-Seq_HELA_Human1.00915993
115TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.00501484
116BRD4_25478319_ChIP-Seq_HGPS_Human1.00320917
117* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00094802
118KDM5A_27292631_Chip-Seq_BREAST_Human0.99471703
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99182025
120WT1_19549856_ChIP-ChIP_CCG9911_Human0.99114461
121NANOG_21062744_ChIP-ChIP_HESCs_Human0.98796695
122KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97777209
123DCP1A_22483619_ChIP-Seq_HELA_Human0.97593111
124VDR_24763502_ChIP-Seq_THP-1_Human0.97306796
125SOX17_20123909_ChIP-Seq_XEN_Mouse0.96812648
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96786532
127MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96736443
128UTX_26944678_Chip-Seq_JUKART_Human0.96562147
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96152176
130OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95808933
131CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95130777
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95061039
133NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94757552
134* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93683651
135TP53_22127205_ChIP-Seq_IMR90_Human0.91099770
136POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89180054
137CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87939430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.71723776
2MP0002877_abnormal_melanocyte_morpholog3.53911721
3MP0006054_spinal_hemorrhage3.41408851
4MP0003300_gastrointestinal_ulcer2.70601907
5MP0003705_abnormal_hypodermis_morpholog2.70355202
6MP0003283_abnormal_digestive_organ2.38502627
7MP0005275_abnormal_skin_tensile2.27609954
8MP0010352_gastrointestinal_tract_polyps2.27342212
9MP0005220_abnormal_exocrine_pancreas2.13477573
10MP0004264_abnormal_extraembryonic_tissu2.06049120
11MP0003566_abnormal_cell_adhesion2.04487065
12MP0003941_abnormal_skin_development2.02356683
13MP0005503_abnormal_tendon_morphology1.96497379
14MP0000013_abnormal_adipose_tissue1.92881642
15MP0003195_calcinosis1.92281005
16MP0004858_abnormal_nervous_system1.84881076
17MP0005623_abnormal_meninges_morphology1.81836094
18MP0004272_abnormal_basement_membrane1.81802284
19MP0001944_abnormal_pancreas_morphology1.78443468
20MP0005451_abnormal_body_composition1.77858029
21MP0003183_abnormal_peptide_metabolism1.69621777
22MP0010234_abnormal_vibrissa_follicle1.64018821
23MP0005076_abnormal_cell_differentiation1.62038059
24MP0002796_impaired_skin_barrier1.57369689
25MP0002896_abnormal_bone_mineralization1.56480250
26MP0005058_abnormal_lysosome_morphology1.55493520
27MP0002693_abnormal_pancreas_physiology1.50198092
28MP0005023_abnormal_wound_healing1.49217503
29MP0009780_abnormal_chondrocyte_physiolo1.46659951
30MP0000678_abnormal_parathyroid_gland1.44119478
31MP0009384_cardiac_valve_regurgitation1.43256539
32MP0008932_abnormal_embryonic_tissue1.34264004
33MP0005501_abnormal_skin_physiology1.34085205
34MP0002139_abnormal_hepatobiliary_system1.33813330
35MP0003279_aneurysm1.33622200
36MP0009643_abnormal_urine_homeostasis1.30792395
37MP0003252_abnormal_bile_duct1.29844941
38MP0002909_abnormal_adrenal_gland1.28523756
39MP0003453_abnormal_keratinocyte_physiol1.28351878
40MP0003693_abnormal_embryo_hatching1.27572489
41MP0008260_abnormal_autophagy1.20982728
42MP0004233_abnormal_muscle_weight1.20894325
43MP0002928_abnormal_bile_duct1.20642089
44MP0000003_abnormal_adipose_tissue1.19605341
45MP0009053_abnormal_anal_canal1.19107235
46MP0001216_abnormal_epidermal_layer1.18591996
47MP0003111_abnormal_nucleus_morphology1.17414008
48MP0002060_abnormal_skin_morphology1.15820110
49MP0004043_abnormal_pH_regulation1.14811987
50MP0002166_altered_tumor_susceptibility1.11851197
51MP0001958_emphysema1.10443486
52MP0000762_abnormal_tongue_morphology1.09559260
53MP0000579_abnormal_nail_morphology1.09536481
54MP0001881_abnormal_mammary_gland1.07474595
55MP0005165_increased_susceptibility_to1.07303016
56MP0005365_abnormal_bile_salt1.07072898
57MP0005508_abnormal_skeleton_morphology1.06777081
58MP0003172_abnormal_lysosome_physiology1.05997080
59MP0000627_abnormal_mammary_gland1.02595782
60MP0004185_abnormal_adipocyte_glucose1.02581587
61MP0000613_abnormal_salivary_gland1.01721828
62MP0000467_abnormal_esophagus_morphology0.99801640
63MP0003448_altered_tumor_morphology0.99563892
64MP0000681_abnormal_thyroid_gland0.98593144
65MP0010368_abnormal_lymphatic_system0.98461335
66MP0001756_abnormal_urination0.97661836
67MP0001533_abnormal_skeleton_physiology0.96287923
68MP0003984_embryonic_growth_retardation0.96213580
69MP0002006_tumorigenesis0.95983139
70MP0001672_abnormal_embryogenesis/_devel0.95877481
71MP0005380_embryogenesis_phenotype0.95877481
72MP0010307_abnormal_tumor_latency0.95695699
73MP0002089_abnormal_postnatal_growth/wei0.95527182
74* MP0005621_abnormal_cell_physiology0.94594046
75MP0002254_reproductive_system_inflammat0.94379795
76MP0005409_darkened_coat_color0.94370416
77MP0002098_abnormal_vibrissa_morphology0.93954665
78MP0002138_abnormal_hepatobiliary_system0.93712592
79MP0009840_abnormal_foam_cell0.93612118
80MP0000350_abnormal_cell_proliferation0.93449403
81MP0004957_abnormal_blastocyst_morpholog0.93131026
82MP0001661_extended_life_span0.93102275
83* MP0002080_prenatal_lethality0.92588654
84* MP0003795_abnormal_bone_structure0.91648287
85MP0005257_abnormal_intraocular_pressure0.91298209
86MP0001243_abnormal_dermal_layer0.90326879
87MP0002088_abnormal_embryonic_growth/wei0.89130045
88MP0009697_abnormal_copulation0.89027893
89MP0000858_altered_metastatic_potential0.87831801
90MP0002933_joint_inflammation0.87398457
91MP0001666_abnormal_nutrient_absorption0.85286002
92MP0010030_abnormal_orbit_morphology0.85189364
93MP0000767_abnormal_smooth_muscle0.85033092
94MP0005390_skeleton_phenotype0.85003238
95MP0000462_abnormal_digestive_system0.84671454
96MP0008007_abnormal_cellular_replicative0.84041889
97MP0004947_skin_inflammation0.83737968
98MP0002295_abnormal_pulmonary_circulatio0.83685714
99MP0001849_ear_inflammation0.83169165
100MP0003385_abnormal_body_wall0.83139571
101MP0000428_abnormal_craniofacial_morphol0.82276311
102MP0003123_paternal_imprinting0.81974503
103MP0003315_abnormal_perineum_morphology0.80729469
104MP0000163_abnormal_cartilage_morphology0.80032155
105MP0000537_abnormal_urethra_morphology0.79438432
106MP0010678_abnormal_skin_adnexa0.78501840
107MP0002078_abnormal_glucose_homeostasis0.77781594
108MP0003806_abnormal_nucleotide_metabolis0.77353004
109MP0010386_abnormal_urinary_bladder0.77038384
110MP0005197_abnormal_uvea_morphology0.77017723
111MP0003942_abnormal_urinary_system0.76731151
112MP0000598_abnormal_liver_morphology0.75426922
113* MP0005384_cellular_phenotype0.75096727
114MP0010771_integument_phenotype0.74845370
115MP0000609_abnormal_liver_physiology0.74272734
116MP0001348_abnormal_lacrimal_gland0.73963303
117MP0002168_other_aberrant_phenotype0.73563781
118MP0009931_abnormal_skin_appearance0.73456339
119MP0003091_abnormal_cell_migration0.72848665
120MP0003077_abnormal_cell_cycle0.72619028
121MP0004197_abnormal_fetal_growth/weight/0.72463401
122MP0000377_abnormal_hair_follicle0.72127565
123MP0003436_decreased_susceptibility_to0.71531835
124MP0000566_synostosis0.70257611
125MP0005408_hypopigmentation0.70012579
126MP0002085_abnormal_embryonic_tissue0.69106554
127* MP0001697_abnormal_embryo_size0.69009749
128MP0002234_abnormal_pharynx_morphology0.68922862
129MP0005379_endocrine/exocrine_gland_phen0.68738365
130MP0002115_abnormal_skeleton_extremities0.67564163
131MP0002113_abnormal_skeleton_development0.66962279
132MP0009672_abnormal_birth_weight0.66347648
133MP0002086_abnormal_extraembryonic_tissu0.65103179
134MP0002135_abnormal_kidney_morphology0.65018489
135MP0005360_urolithiasis0.64975066
136MP0000477_abnormal_intestine_morphology0.64547744
137MP0001730_embryonic_growth_arrest0.64538098
138MP0001765_abnormal_ion_homeostasis0.64084172
139MP0000490_abnormal_crypts_of0.62946113
140MP0001542_abnormal_bone_strength0.61400435
141MP0003115_abnormal_respiratory_system0.61361251
142MP0000534_abnormal_ureter_morphology0.61156750
143MP0004782_abnormal_surfactant_physiolog0.60867496
144MP0004808_abnormal_hematopoietic_stem0.60699636
145MP0003191_abnormal_cellular_cholesterol0.60252636
146MP0001915_intracranial_hemorrhage0.59282831
147MP0010155_abnormal_intestine_physiology0.59186997

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.42137140
2Hypoglycemic coma (HP:0001325)4.00651987
3Premature rupture of membranes (HP:0001788)3.93262576
4Cervical subluxation (HP:0003308)3.90686019
5Hypoglycemic seizures (HP:0002173)3.58311072
6Mucopolysacchariduria (HP:0008155)3.44772019
7Urinary glycosaminoglycan excretion (HP:0003541)3.44772019
8Hyperinsulinemic hypoglycemia (HP:0000825)3.42410472
9Dysostosis multiplex (HP:0000943)3.17678555
10Abnormality of the intrinsic pathway (HP:0010989)3.17007669
11Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.16045974
12Symptomatic seizures (HP:0011145)3.08136956
13Abnormality of mucopolysaccharide metabolism (HP:0011020)3.02834451
14Abnormality of polysaccharide metabolism (HP:0011012)3.02834451
15Abnormality of glycosaminoglycan metabolism (HP:0004371)3.02834451
16Arterial tortuosity (HP:0005116)2.88718182
17Cerebral aneurysm (HP:0004944)2.86853029
18Flat acetabular roof (HP:0003180)2.83544914
19Thoracolumbar scoliosis (HP:0002944)2.82437519
20Deep venous thrombosis (HP:0002625)2.78521909
21Hyperglycemia (HP:0003074)2.73580092
22Ankle contracture (HP:0006466)2.67754730
23Beaking of vertebral bodies (HP:0004568)2.67313045
24Aortic dissection (HP:0002647)2.63535954
25Aortic aneurysm (HP:0004942)2.62069728
26Abnormality of endocrine pancreas physiology (HP:0012093)2.58181352
27Abnormality of the pancreatic islet cells (HP:0006476)2.58181352
28Late onset (HP:0003584)2.57005187
29Thin bony cortex (HP:0002753)2.50660028
30Vacuolated lymphocytes (HP:0001922)2.48850486
31Abnormality of the common coagulation pathway (HP:0010990)2.48339337
32Vertebral compression fractures (HP:0002953)2.44940152
33Right ventricular cardiomyopathy (HP:0011663)2.44578786
34Abnormality of carpal bone ossification (HP:0006257)2.39417520
35Abnormal pancreas size (HP:0012094)2.39230568
36Atrophic scars (HP:0001075)2.39161183
37Soft skin (HP:0000977)2.36842103
38Nonimmune hydrops fetalis (HP:0001790)2.35623871
39Selective tooth agenesis (HP:0001592)2.33692066
40Ankyloglossia (HP:0010296)2.33436488
41Abnormal delivery (HP:0001787)2.32005776
42Abnormality of the distal phalanges of the toes (HP:0010182)2.31468148
43Dilatation of the ascending aorta (HP:0005111)2.29450921
44Generalized aminoaciduria (HP:0002909)2.28125812
45Ketoacidosis (HP:0001993)2.21013427
46Abnormality of oral frenula (HP:0000190)2.20671208
47Severe short stature (HP:0003510)2.20570195
48Bladder diverticulum (HP:0000015)2.20423021
49Aneurysm (HP:0002617)2.19746196
50Hand muscle atrophy (HP:0009130)2.19597662
51Hyperacusis (HP:0010780)2.18560332
52Abnormality of the Achilles tendon (HP:0005109)2.16237602
53Trismus (HP:0000211)2.15840450
54Achilles tendon contracture (HP:0001771)2.15067397
55Shallow orbits (HP:0000586)2.14667634
56Back pain (HP:0003418)2.13831292
57Elbow flexion contracture (HP:0002987)2.12219628
58Abnormality of the anterior horn cell (HP:0006802)2.11540378
59Degeneration of anterior horn cells (HP:0002398)2.11540378
60Pancreatic islet-cell hyperplasia (HP:0004510)2.09511777
61Peritonitis (HP:0002586)2.08696054
62Missing ribs (HP:0000921)2.07177964
63Blue sclerae (HP:0000592)2.06778982
64Insulin-resistant diabetes mellitus (HP:0000831)2.06402941
65Insulin resistance (HP:0000855)2.06132707
66Breech presentation (HP:0001623)2.06023509
67Abnormality of the acetabulum (HP:0003170)2.05467210
68Natal tooth (HP:0000695)2.04300582
69Ulnar bowing (HP:0003031)2.02588896
70Pterygium (HP:0001059)2.02255763
71Abdominal distention (HP:0003270)2.00870515
72Spondylolisthesis (HP:0003302)2.00394444
73Platyspondyly (HP:0000926)1.99272886
74Abnormal ossification of hand bones (HP:0005921)1.97970063
75Unilateral renal agenesis (HP:0000122)1.96294531
76Increased cerebral lipofuscin (HP:0011813)1.95412611
77Neonatal short-limb short stature (HP:0008921)1.95303369
78Spinal rigidity (HP:0003306)1.94452707
79Deviation of the thumb (HP:0009603)1.92260411
80Broad metatarsal (HP:0001783)1.91226216
81Thrombocytosis (HP:0001894)1.88719775
82Advanced eruption of teeth (HP:0006288)1.88320845
83Wormian bones (HP:0002645)1.88161051
84Orthostatic hypotension (HP:0001278)1.86324274
85Follicular hyperkeratosis (HP:0007502)1.85605475
86Asymmetry of the thorax (HP:0001555)1.84751892
87Abnormality of the calcaneus (HP:0008364)1.84605842
88Abnormality of dentin (HP:0010299)1.84536860
89Osteolytic defects of the phalanges of the hand (HP:0009771)1.84206782
90Osteolytic defects of the hand bones (HP:0009699)1.84206782
91Protuberant abdomen (HP:0001538)1.82734193
92Coxa vara (HP:0002812)1.81967092
93Joint stiffness (HP:0001387)1.81265359
9411 pairs of ribs (HP:0000878)1.80270518
95Bowel diverticulosis (HP:0005222)1.79672088
96Disproportionate tall stature (HP:0001519)1.79200282
97Large for gestational age (HP:0001520)1.79182196
98Small epiphyses (HP:0010585)1.79027493
99Abnormal tarsal ossification (HP:0008369)1.78505607
100Interstitial pulmonary disease (HP:0006530)1.78042764
101Biconcave vertebral bodies (HP:0004586)1.77989651
102Cupped ribs (HP:0000887)1.77869810
103Joint laxity (HP:0001388)1.77816841
104Short nail (HP:0001799)1.77300773
105Abnormality of complement system (HP:0005339)1.77143733
106Cardiovascular calcification (HP:0011915)1.75703765
107Hyperparathyroidism (HP:0000843)1.75584617
108Abnormality of calcium-phosphate metabolism (HP:0100530)1.75484492
109Fragile skin (HP:0001030)1.75249361
110Mitral stenosis (HP:0001718)1.75186028
111Increased neuronal autofluorescent lipopigment (HP:0002074)1.74874216
112Cholecystitis (HP:0001082)1.74693590
113Abnormal gallbladder physiology (HP:0012438)1.74693590
114Onycholysis (HP:0001806)1.74565057
115Mildly elevated creatine phosphokinase (HP:0008180)1.74478405
116Long toe (HP:0010511)1.74305818
117Renal duplication (HP:0000075)1.72706509
118Hemorrhage of the eye (HP:0011885)1.72442207
119Abnormality of aromatic amino acid family metabolism (HP:0004338)1.72421391
120Distal upper limb amyotrophy (HP:0007149)1.72274659
121Upper limb amyotrophy (HP:0009129)1.72274659
122Spastic diplegia (HP:0001264)1.71961161
123Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.71386010
124Vertebral hypoplasia (HP:0008417)1.71386010
125Exostoses (HP:0100777)1.69781146
126Mitral valve prolapse (HP:0001634)1.69225250
127Genu recurvatum (HP:0002816)1.69198073
128Abnormal foot bone ossification (HP:0010675)1.68488837
129Broad face (HP:0000283)1.67707964
130Hypoplasia of the odontoid process (HP:0003311)1.67501328
131Insomnia (HP:0100785)1.67318119
132Vascular tortuosity (HP:0004948)1.65521039
133Subacute progressive viral hepatitis (HP:0006572)1.65449449
134Fragile nails (HP:0001808)1.65305010
135Metaphyseal cupping (HP:0003021)1.65053438
136Insidious onset (HP:0003587)1.64454126
137Termporal pattern (HP:0011008)1.64454126
138Pili torti (HP:0003777)1.64211407
139Hyperextensible skin (HP:0000974)1.63725925
140Abnormality of liposaccharide metabolism (HP:0010968)1.62874735
141Abnormality of glycosphingolipid metabolism (HP:0004343)1.62874735
142Abnormality of glycolipid metabolism (HP:0010969)1.62874735
143Proximal placement of thumb (HP:0009623)1.62139983
144Distal lower limb amyotrophy (HP:0008944)1.60551554
145Thin skin (HP:0000963)1.60354231
146Epiphyseal dysplasia (HP:0002656)1.59744594
147Exocrine pancreatic insufficiency (HP:0001738)1.58408419
148Radial bowing (HP:0002986)1.57270287
149Abnormality of monocarboxylic acid metabolism (HP:0010996)1.57154467
150Congenital glaucoma (HP:0001087)1.57084224
151Hematochezia (HP:0002573)1.56871564
152Ovoid vertebral bodies (HP:0003300)1.56860568
153Ectopia lentis (HP:0001083)1.54030639
154Disproportionate short-trunk short stature (HP:0003521)1.54023933
155Abnormal glycosylation (HP:0012345)1.53964940
156Abnormal protein N-linked glycosylation (HP:0012347)1.53964940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.63712209
2PASK3.47311773
3TRIB33.22822619
4MST1R2.82118236
5SCYL22.59417842
6SMG12.49417065
7TESK12.43500478
8PKN22.40901994
9FLT32.32844276
10INSRR2.18927247
11FRK2.12548365
12PDGFRA2.10483601
13EPHA22.05457571
14PTK62.01274477
15MAPK151.97928232
16LATS21.95348653
17TAOK31.90209472
18NME21.84855867
19ICK1.71510351
20FGFR41.62490780
21BRSK21.56944480
22EPHA31.55839547
23SIK11.54503236
24ARAF1.53611098
25PAK41.51027163
26DDR21.50324657
27LATS11.49053540
28PTK21.47018479
29RPS6KA41.40630103
30RIPK11.39879136
31TTK1.39738039
32LRRK21.39050240
33TESK21.37739055
34KDR1.24324582
35EEF2K1.23227902
36EIF2AK31.21552071
37DYRK1B1.18366427
38MAP3K31.17162855
39HIPK21.16196740
40SRPK11.15176062
41JAK31.13435550
42TGFBR11.11159763
43MAP3K21.10880638
44STK101.10879552
45PAK21.07097938
46MAP3K101.06668861
47PBK1.05508792
48LIMK11.05464899
49TGFBR21.05111530
50FER1.05088037
51BCKDK1.04974489
52PIK3CG1.02814095
53EPHB11.01481842
54LMTK21.00663817
55ERBB41.00181681
56EPHB20.99007154
57NEK90.98341943
58TYK20.98077733
59MET0.96684476
60ZAP700.94760424
61ERBB30.91774044
62TTN0.90800989
63PRPF4B0.88555994
64ACVR1B0.88147548
65PIM20.86124713
66MYLK0.85951663
67MAP3K140.85580915
68CDK60.80871143
69JAK10.80681610
70BMX0.80502626
71MTOR0.80314769
72STK30.78984240
73WNK40.78887958
74MAPKAPK30.76614351
75CDK80.76353590
76RPS6KB20.75537290
77FGFR30.74607615
78BUB10.74376146
79CDK120.74078704
80VRK20.72970987
81MAP3K80.72911672
82EIF2AK10.71948248
83TRPM70.71501316
84PAK30.69916207
85ITK0.69914002
86BTK0.67692352
87MAP2K20.65733557
88TBK10.64670531
89MAP2K30.64334084
90NEK20.64115078
91CDK90.63906051
92MOS0.63323740
93CLK10.62897721
94IRAK30.62866314
95BCR0.61263396
96NEK10.61201371
97MAP3K10.60846849
98PRKG20.59393298
99NTRK10.58514687
100CAMK1D0.58195094
101PRKD30.58091402
102JAK20.57348876
103TEC0.56233831
104FGFR10.56098783
105CHUK0.55323597
106TAOK20.54296981
107CDK40.51445504
108MAP3K120.51222891
109CAMKK20.50572164
110PDGFRB0.50337949
111TSSK60.49117777
112CDC42BPA0.48631729
113CSK0.47824656
114KSR20.47751001
115MST40.46857776
116MAP3K130.45987074
117WNK30.44106446
118AURKB0.42722832
119BRSK10.41871116
120RET0.41128303
121PRKCI0.39705674
122BRAF0.39564439
123CHEK10.39102385
124MAPKAPK20.38838601
125MAPK110.38833662
126ILK0.38262218
127IGF1R0.37993389
128CDC70.37687081
129MAP4K10.37259887
130TIE10.35716098
131MAP2K10.35585985
132CAMK1G0.35327814
133ROCK20.34804754
134ALK0.34701064
135CDK140.34531747
136CDK180.34295445
137KIT0.34264514
138CDK150.34264104
139CDK70.33278623
140CDK11A0.33234294
141IRAK40.32575073
142BRD40.32462651

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.47252339
2Protein export_Homo sapiens_hsa030604.80796246
3* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.11173310
4N-Glycan biosynthesis_Homo sapiens_hsa005102.71077237
5Sulfur metabolism_Homo sapiens_hsa009202.39522497
6Selenocompound metabolism_Homo sapiens_hsa004502.29978693
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.10497870
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03872836
9Lysosome_Homo sapiens_hsa041421.92868274
10Other glycan degradation_Homo sapiens_hsa005111.91672065
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74541365
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.61507061
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.60411113
14* Antigen processing and presentation_Homo sapiens_hsa046121.60009399
15Proteasome_Homo sapiens_hsa030501.57849341
16Folate biosynthesis_Homo sapiens_hsa007901.38723951
17ECM-receptor interaction_Homo sapiens_hsa045121.31708054
18Bladder cancer_Homo sapiens_hsa052191.31577792
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27278592
20Legionellosis_Homo sapiens_hsa051341.25433839
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23157229
22Galactose metabolism_Homo sapiens_hsa000521.19507152
23Steroid biosynthesis_Homo sapiens_hsa001001.18023719
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17748994
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15195822
26Renin-angiotensin system_Homo sapiens_hsa046141.14848588
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13648156
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13096121
29Thyroid hormone synthesis_Homo sapiens_hsa049181.12582162
30Tryptophan metabolism_Homo sapiens_hsa003801.11668169
31Protein digestion and absorption_Homo sapiens_hsa049741.09810821
32One carbon pool by folate_Homo sapiens_hsa006701.07722090
33Focal adhesion_Homo sapiens_hsa045101.07255791
34Vibrio cholerae infection_Homo sapiens_hsa051101.06601560
35Thyroid cancer_Homo sapiens_hsa052161.02336625
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01989391
37Small cell lung cancer_Homo sapiens_hsa052220.99853357
38Arginine biosynthesis_Homo sapiens_hsa002200.97833984
39p53 signaling pathway_Homo sapiens_hsa041150.97151953
40Adherens junction_Homo sapiens_hsa045200.96410466
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96242577
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96218520
43Fatty acid elongation_Homo sapiens_hsa000620.95636044
44Spliceosome_Homo sapiens_hsa030400.95277172
45Chronic myeloid leukemia_Homo sapiens_hsa052200.93221237
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90466107
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89774492
48Base excision repair_Homo sapiens_hsa034100.88308012
49Proteoglycans in cancer_Homo sapiens_hsa052050.87170492
50Starch and sucrose metabolism_Homo sapiens_hsa005000.86372035
51Amoebiasis_Homo sapiens_hsa051460.83469054
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.81949218
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.81938573
54Insulin resistance_Homo sapiens_hsa049310.81909129
55Mismatch repair_Homo sapiens_hsa034300.80557911
56Fatty acid degradation_Homo sapiens_hsa000710.75811581
57Complement and coagulation cascades_Homo sapiens_hsa046100.74879846
58Lysine degradation_Homo sapiens_hsa003100.73781396
59Prion diseases_Homo sapiens_hsa050200.72814373
60Toxoplasmosis_Homo sapiens_hsa051450.71341513
61Fatty acid biosynthesis_Homo sapiens_hsa000610.71096114
62Sphingolipid metabolism_Homo sapiens_hsa006000.70715864
63Arginine and proline metabolism_Homo sapiens_hsa003300.70312413
64Caffeine metabolism_Homo sapiens_hsa002320.70217257
65Pyruvate metabolism_Homo sapiens_hsa006200.70097743
66Cell cycle_Homo sapiens_hsa041100.69211622
67Prolactin signaling pathway_Homo sapiens_hsa049170.68223777
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66403657
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65798619
70Shigellosis_Homo sapiens_hsa051310.65370757
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64746351
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64318221
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.64149715
74Fat digestion and absorption_Homo sapiens_hsa049750.63926888
75Tyrosine metabolism_Homo sapiens_hsa003500.63763155
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63317691
77Salmonella infection_Homo sapiens_hsa051320.62160516
78Leishmaniasis_Homo sapiens_hsa051400.61632754
79Prostate cancer_Homo sapiens_hsa052150.61500093
80Viral carcinogenesis_Homo sapiens_hsa052030.60412316
81Pancreatic cancer_Homo sapiens_hsa052120.58583367
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57262616
83mRNA surveillance pathway_Homo sapiens_hsa030150.57089660
84DNA replication_Homo sapiens_hsa030300.56288442
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55511834
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55373836
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55168765
88MicroRNAs in cancer_Homo sapiens_hsa052060.55020281
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.54570720
90Apoptosis_Homo sapiens_hsa042100.54470690
91Histidine metabolism_Homo sapiens_hsa003400.53875209
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52314546
93Pertussis_Homo sapiens_hsa051330.52218460
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51809781
95HTLV-I infection_Homo sapiens_hsa051660.51688100
96Non-homologous end-joining_Homo sapiens_hsa034500.51625201
97Hepatitis B_Homo sapiens_hsa051610.49325468
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49168512
99Pathways in cancer_Homo sapiens_hsa052000.49134109
100Tight junction_Homo sapiens_hsa045300.48767280
101Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48428954
102TGF-beta signaling pathway_Homo sapiens_hsa043500.48329751
103Pentose phosphate pathway_Homo sapiens_hsa000300.48136998
104Phagosome_Homo sapiens_hsa041450.47593966
105RNA transport_Homo sapiens_hsa030130.47217107
106Nucleotide excision repair_Homo sapiens_hsa034200.46965897
107ABC transporters_Homo sapiens_hsa020100.46947867
108Type II diabetes mellitus_Homo sapiens_hsa049300.46452778
109Hepatitis C_Homo sapiens_hsa051600.45055856
110Type I diabetes mellitus_Homo sapiens_hsa049400.41902820
111Non-small cell lung cancer_Homo sapiens_hsa052230.41505599
112Glutathione metabolism_Homo sapiens_hsa004800.36432896
113Hippo signaling pathway_Homo sapiens_hsa043900.36420118
114Biosynthesis of amino acids_Homo sapiens_hsa012300.35402432
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.34404026
116Staphylococcus aureus infection_Homo sapiens_hsa051500.34028778
117Phenylalanine metabolism_Homo sapiens_hsa003600.33434516
118TNF signaling pathway_Homo sapiens_hsa046680.33139938
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31332522
120Fatty acid metabolism_Homo sapiens_hsa012120.29300974
121Malaria_Homo sapiens_hsa051440.28900005
122Endometrial cancer_Homo sapiens_hsa052130.28864837
123mTOR signaling pathway_Homo sapiens_hsa041500.27497110
124Fructose and mannose metabolism_Homo sapiens_hsa000510.27448860
125Carbon metabolism_Homo sapiens_hsa012000.26884647
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.25882715
127Acute myeloid leukemia_Homo sapiens_hsa052210.25770442
128Viral myocarditis_Homo sapiens_hsa054160.25642929
129Vitamin digestion and absorption_Homo sapiens_hsa049770.25523228
130Glucagon signaling pathway_Homo sapiens_hsa049220.25522840
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24893883
132Measles_Homo sapiens_hsa051620.24847862
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24616347

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