PDIA3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.10562149
2sequestering of actin monomers (GO:0042989)8.06699764
3ATP synthesis coupled proton transport (GO:0015986)7.17251656
4energy coupled proton transport, down electrochemical gradient (GO:0015985)7.17251656
5ribosomal small subunit assembly (GO:0000028)7.16641323
6viral transcription (GO:0019083)6.97730123
7translational termination (GO:0006415)6.65426410
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.14728393
9cotranslational protein targeting to membrane (GO:0006613)6.12203464
10protein targeting to ER (GO:0045047)6.04180849
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.02643239
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.77206179
13cytidine deamination (GO:0009972)5.76022734
14cytidine metabolic process (GO:0046087)5.76022734
15cytidine catabolic process (GO:0006216)5.76022734
16protein localization to endoplasmic reticulum (GO:0070972)5.68531800
17translational elongation (GO:0006414)5.64406807
18respiratory electron transport chain (GO:0022904)5.22684005
19pyrimidine ribonucleoside catabolic process (GO:0046133)5.21494995
20maturation of SSU-rRNA (GO:0030490)5.09782747
21electron transport chain (GO:0022900)5.08655429
22cellular protein complex disassembly (GO:0043624)5.01669427
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.98449539
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.92850802
25viral life cycle (GO:0019058)4.87430775
26regulation of activation of Janus kinase activity (GO:0010533)4.83850258
27establishment of protein localization to mitochondrial membrane (GO:0090151)4.81796916
28prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.68509992
29ribosomal small subunit biogenesis (GO:0042274)4.51748854
30protein complex disassembly (GO:0043241)4.25067239
31lung lobe morphogenesis (GO:0060463)4.24550405
32translational initiation (GO:0006413)4.20837638
33DNA deamination (GO:0045006)4.12983393
34prostate gland growth (GO:0060736)4.08623390
35macromolecular complex disassembly (GO:0032984)4.05855951
36protein neddylation (GO:0045116)4.00736621
37protein targeting to membrane (GO:0006612)4.00623378
38ribosomal large subunit biogenesis (GO:0042273)3.89140991
39positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.75760740
40ATP biosynthetic process (GO:0006754)3.74430303
41chaperone-mediated protein transport (GO:0072321)3.69687772
42positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.69099571
43translation (GO:0006412)3.65539307
44hydrogen ion transmembrane transport (GO:1902600)3.61740298
45DNA damage response, detection of DNA damage (GO:0042769)3.59967339
46behavioral response to nicotine (GO:0035095)3.44767739
47otic vesicle formation (GO:0030916)3.39968102
48growth hormone receptor signaling pathway (GO:0060396)3.39901744
49proton transport (GO:0015992)3.39580448
50protein complex biogenesis (GO:0070271)3.36978907
51platelet dense granule organization (GO:0060155)3.34572756
52regulation of mitochondrial translation (GO:0070129)3.32638905
53nuclear-transcribed mRNA catabolic process (GO:0000956)3.31001171
54hydrogen transport (GO:0006818)3.30384521
55dopaminergic neuron differentiation (GO:0071542)3.28271291
56negative regulation by host of viral transcription (GO:0043922)3.26282032
57purine nucleoside triphosphate biosynthetic process (GO:0009145)3.21966456
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.18282252
59mRNA catabolic process (GO:0006402)3.10888613
60mitochondrial respiratory chain complex assembly (GO:0033108)3.06429354
61regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.05834356
62response to interferon-beta (GO:0035456)3.04530170
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.04438226
64NADH dehydrogenase complex assembly (GO:0010257)3.04438226
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04438226
66positive regulation of gastrulation (GO:2000543)3.02189909
67cellular response to growth hormone stimulus (GO:0071378)3.01086612
68exocrine pancreas development (GO:0031017)2.99500021
69adaptation of signaling pathway (GO:0023058)2.95617928
70lung vasculature development (GO:0060426)2.94945436
71negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88730371
72inner mitochondrial membrane organization (GO:0007007)2.88324019
73spliceosomal complex assembly (GO:0000245)2.82048134
74regulation of cellular amino acid metabolic process (GO:0006521)2.80938437
75cellular response to interferon-beta (GO:0035458)2.79241850
76protein-cofactor linkage (GO:0018065)2.78924053
77establishment of protein localization to membrane (GO:0090150)2.73932157
78RNA catabolic process (GO:0006401)2.73086191
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.68834019
80ribonucleoside triphosphate biosynthetic process (GO:0009201)2.68373618
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.58722332
82protein targeting (GO:0006605)2.56600735
83branching involved in prostate gland morphogenesis (GO:0060442)2.56332191
84midbrain development (GO:0030901)2.53897205
85regulation of non-canonical Wnt signaling pathway (GO:2000050)2.53812912
86negative regulation of ligase activity (GO:0051352)2.53619656
87negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.53619656
88regulation of phospholipase A2 activity (GO:0032429)2.52415069
89negative regulation of androgen receptor signaling pathway (GO:0060766)2.52313626
90signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.52113352
91signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.52113352
92signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.52113352
93lung secretory cell differentiation (GO:0061140)2.49859494
94positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.49839261
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.48359740
96signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.48359740
97establishment of protein localization to organelle (GO:0072594)2.47501871
98regulation of smooth muscle cell apoptotic process (GO:0034391)2.47246032
99antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.44751446
100intracellular protein transmembrane import (GO:0044743)2.43661098

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.36234334
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.21588897
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.64729735
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.60316944
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48895507
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02268362
7VDR_22108803_ChIP-Seq_LS180_Human3.01850428
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.72568801
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71613197
10ELK1_19687146_ChIP-ChIP_HELA_Human2.70846623
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.50409029
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.50043093
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38865325
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.25962762
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.18029705
16IGF1R_20145208_ChIP-Seq_DFB_Human2.11394469
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.09495812
18VDR_23849224_ChIP-Seq_CD4+_Human2.08400028
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.06751138
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.97976013
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95118719
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94181739
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90106587
24TTF2_22483619_ChIP-Seq_HELA_Human1.86318814
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.85903160
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84728234
27EWS_26573619_Chip-Seq_HEK293_Human1.82701538
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79610766
29POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.72863438
30ZNF274_21170338_ChIP-Seq_K562_Hela1.63026457
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.62932021
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59670739
33ERG_20517297_ChIP-Seq_VCAP_Human1.58989704
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58457193
35SOX2_16153702_ChIP-ChIP_HESCs_Human1.57867079
36SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56173521
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54132008
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53047479
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52566184
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.52294475
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49681390
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48231804
43XRN2_22483619_ChIP-Seq_HELA_Human1.47604682
44NANOG_16153702_ChIP-ChIP_HESCs_Human1.46976346
45MYC_18940864_ChIP-ChIP_HL60_Human1.46645627
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46282314
47FUS_26573619_Chip-Seq_HEK293_Human1.40551039
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39947782
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35203360
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34633436
51FOXP3_21729870_ChIP-Seq_TREG_Human1.33201208
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33145524
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.32552401
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.31896125
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31339714
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30732748
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30278435
58P300_19829295_ChIP-Seq_ESCs_Human1.27518505
59TP53_22573176_ChIP-Seq_HFKS_Human1.27203378
60AR_20517297_ChIP-Seq_VCAP_Human1.26675159
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24249804
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23732268
63TAF15_26573619_Chip-Seq_HEK293_Human1.22332208
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.21327624
65BCAT_22108803_ChIP-Seq_LS180_Human1.15970712
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13185682
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.09285248
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09016630
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08782903
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07536021
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04358318
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03809197
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03596563
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02694647
75IRF1_19129219_ChIP-ChIP_H3396_Human1.01519581
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01010638
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00236218
78AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98096406
79E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97463420
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97402590
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97036956
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96415393
83EZH2_22144423_ChIP-Seq_EOC_Human0.95549851
84HTT_18923047_ChIP-ChIP_STHdh_Human0.94472478
85ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93867608
86MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93838141
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93032330
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.93032330
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92474902
90SALL1_21062744_ChIP-ChIP_HESCs_Human0.88934064
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87942671
92SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86405207
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86099505
94ER_23166858_ChIP-Seq_MCF-7_Human0.85332538
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.84981781
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84343002
97CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83086121
98MYC_19079543_ChIP-ChIP_MESCs_Mouse0.82951951
99FLI1_27457419_Chip-Seq_LIVER_Mouse0.81651530
100SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80846462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.41235816
2MP0000566_synostosis4.77011665
3MP0001348_abnormal_lacrimal_gland3.38312411
4MP0006072_abnormal_retinal_apoptosis2.96592934
5MP0000569_abnormal_digit_pigmentation2.95998409
6MP0003011_delayed_dark_adaptation2.88718925
7MP0010030_abnormal_orbit_morphology2.54396953
8MP0002277_abnormal_respiratory_mucosa2.41388194
9MP0004742_abnormal_vestibular_system2.35059704
10MP0005084_abnormal_gallbladder_morpholo2.31806619
11MP0006292_abnormal_olfactory_placode2.31479310
12MP0008789_abnormal_olfactory_epithelium2.21542394
13MP0003283_abnormal_digestive_organ2.21261862
14MP0005499_abnormal_olfactory_system2.17159128
15MP0005394_taste/olfaction_phenotype2.17159128
16MP0005408_hypopigmentation2.06799970
17MP0003787_abnormal_imprinting1.92943578
18MP0000049_abnormal_middle_ear1.89443281
19MP0002822_catalepsy1.85491631
20MP0002282_abnormal_trachea_morphology1.84097370
21MP0003959_abnormal_lean_body1.80246116
22MP0001293_anophthalmia1.79676805
23MP0000372_irregular_coat_pigmentation1.79248115
24MP0001346_abnormal_lacrimal_gland1.74478580
25MP0002938_white_spotting1.64822052
26MP0001905_abnormal_dopamine_level1.63805920
27MP0000537_abnormal_urethra_morphology1.62044791
28MP0003938_abnormal_ear_development1.61355382
29MP0005671_abnormal_response_to1.59323020
30MP0001440_abnormal_grooming_behavior1.55429438
31MP0008877_abnormal_DNA_methylation1.54386750
32MP0005253_abnormal_eye_physiology1.51797181
33MP0003121_genomic_imprinting1.51662387
34MP0003315_abnormal_perineum_morphology1.48520193
35MP0002163_abnormal_gland_morphology1.46453351
36MP0003937_abnormal_limbs/digits/tail_de1.45269462
37MP0002697_abnormal_eye_size1.44401087
38MP0001529_abnormal_vocalization1.42039542
39MP0003638_abnormal_response/metabolism_1.41817172
40MP0001286_abnormal_eye_development1.35331964
41MP0002751_abnormal_autonomic_nervous1.32111919
42MP0002638_abnormal_pupillary_reflex1.30735559
43MP0002928_abnormal_bile_duct1.28759890
44MP0001666_abnormal_nutrient_absorption1.28224582
45MP0002735_abnormal_chemical_nociception1.28085998
46MP0001299_abnormal_eye_distance/1.25926904
47MP0008961_abnormal_basal_metabolism1.24325507
48MP0003136_yellow_coat_color1.23266317
49MP0003122_maternal_imprinting1.21705893
50MP0005379_endocrine/exocrine_gland_phen1.20631161
51MP0004145_abnormal_muscle_electrophysio1.19384858
52MP0004142_abnormal_muscle_tone1.19279617
53MP0005377_hearing/vestibular/ear_phenot1.17351545
54MP0003878_abnormal_ear_physiology1.17351545
55MP0001542_abnormal_bone_strength1.11892982
56MP0002233_abnormal_nose_morphology1.07544860
57MP0005391_vision/eye_phenotype1.05913146
58MP0000627_abnormal_mammary_gland1.03131466
59MP0000647_abnormal_sebaceous_gland0.99565077
60MP0000026_abnormal_inner_ear0.97772712
61MP0000631_abnormal_neuroendocrine_gland0.96379666
62MP0000163_abnormal_cartilage_morphology0.95948467
63MP0003890_abnormal_embryonic-extraembry0.93923378
64MP0003123_paternal_imprinting0.93775069
65MP0000383_abnormal_hair_follicle0.91502577
66MP0009250_abnormal_appendicular_skeleto0.91237514
67MP0002102_abnormal_ear_morphology0.89622616
68MP0004885_abnormal_endolymph0.86403437
69MP0002095_abnormal_skin_pigmentation0.85399632
70MP0000428_abnormal_craniofacial_morphol0.84247253
71MP0000762_abnormal_tongue_morphology0.82393065
72MP0001879_abnormal_lymphatic_vessel0.80300943
73MP0002092_abnormal_eye_morphology0.79585451
74MP0006276_abnormal_autonomic_nervous0.79484973
75MP0002932_abnormal_joint_morphology0.78337925
76MP0005195_abnormal_posterior_eye0.77532896
77MP0005187_abnormal_penis_morphology0.76921317
78MP0002234_abnormal_pharynx_morphology0.76395704
79MP0002295_abnormal_pulmonary_circulatio0.76080811
80MP0005551_abnormal_eye_electrophysiolog0.75961680
81MP0001881_abnormal_mammary_gland0.74227356
82MP0001340_abnormal_eyelid_morphology0.73651293
83MP0002184_abnormal_innervation0.73041587
84MP0005083_abnormal_biliary_tract0.71863616
85MP0003119_abnormal_digestive_system0.71737715
86MP0002166_altered_tumor_susceptibility0.71377601
87MP0001984_abnormal_olfaction0.71167283
88MP0002138_abnormal_hepatobiliary_system0.71017697
89MP0002109_abnormal_limb_morphology0.70713255
90MP0002006_tumorigenesis0.63049354
91MP0002653_abnormal_ependyma_morphology0.62953384
92MP0003755_abnormal_palate_morphology0.62508388
93MP0001485_abnormal_pinna_reflex0.61482647
94MP0003880_abnormal_central_pattern0.61303702
95MP0001764_abnormal_homeostasis0.60912011
96MP0002115_abnormal_skeleton_extremities0.60076717
97MP0004133_heterotaxia0.59901572
98MP0005197_abnormal_uvea_morphology0.59396678
99MP0003137_abnormal_impulse_conducting0.58856043
100MP0005360_urolithiasis0.57683118

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.00437182
2Reticulocytopenia (HP:0001896)4.97214846
3Abnormality of cells of the erythroid lineage (HP:0012130)4.87173779
4Increased hepatocellular lipid droplets (HP:0006565)4.78569157
5Lipid accumulation in hepatocytes (HP:0006561)4.56400082
6Mitochondrial inheritance (HP:0001427)4.29539187
7Acute necrotizing encephalopathy (HP:0006965)4.25017319
8Renal Fanconi syndrome (HP:0001994)4.12947647
9Abnormal mitochondria in muscle tissue (HP:0008316)3.79964667
10Aplastic anemia (HP:0001915)3.71611751
11Progressive macrocephaly (HP:0004481)3.71427490
12Macrocytic anemia (HP:0001972)3.68207777
13Hepatocellular necrosis (HP:0001404)3.63576195
14Hepatic necrosis (HP:0002605)3.55190914
15Increased CSF lactate (HP:0002490)3.44864509
16Acute encephalopathy (HP:0006846)3.41262393
17Congenital, generalized hypertrichosis (HP:0004540)3.32655733
18Oral leukoplakia (HP:0002745)3.29220457
19Aplasia/Hypoplasia of the sacrum (HP:0008517)3.13043712
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10989308
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10989308
22Septo-optic dysplasia (HP:0100842)3.04604825
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.99330590
24Cerebral edema (HP:0002181)2.96510169
25Increased intramyocellular lipid droplets (HP:0012240)2.86913045
26Hemivertebrae (HP:0002937)2.81597021
27Bilateral microphthalmos (HP:0007633)2.81255205
28Stenosis of the external auditory canal (HP:0000402)2.77394002
29Exertional dyspnea (HP:0002875)2.72901638
30Abnormality of the phalanges of the 2nd finger (HP:0009541)2.70521546
31Prolonged partial thromboplastin time (HP:0003645)2.60868033
32Pancreatic fibrosis (HP:0100732)2.59394119
33Abnormality of renal resorption (HP:0011038)2.55945915
34Absent septum pellucidum (HP:0001331)2.51822210
35Symphalangism affecting the phalanges of the hand (HP:0009773)2.49445712
36Anophthalmia (HP:0000528)2.48931106
37Abnormality of the parietal bone (HP:0002696)2.48319982
38Respiratory difficulties (HP:0002880)2.46631649
39Abnormality of the middle phalanges of the toes (HP:0010183)2.40800198
40Increased muscle lipid content (HP:0009058)2.40354659
41Hyperphosphaturia (HP:0003109)2.38162620
42Rib fusion (HP:0000902)2.36347191
43Pallor (HP:0000980)2.31798649
44Type I transferrin isoform profile (HP:0003642)2.22015914
45Partial duplication of the phalanx of hand (HP:0009999)2.21961414
46Generalized aminoaciduria (HP:0002909)2.21014854
47Synostosis involving the elbow (HP:0003938)2.20424863
48Humeroradial synostosis (HP:0003041)2.20424863
49Lactic acidosis (HP:0003128)2.18484653
50Woolly hair (HP:0002224)2.16720887
51Maternal diabetes (HP:0009800)2.15956280
52Partial duplication of thumb phalanx (HP:0009944)2.10606847
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10270861
54Abnormality of the septum pellucidum (HP:0007375)2.07452721
55Missing ribs (HP:0000921)2.05665112
56Esophageal atresia (HP:0002032)2.01038796
57Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.00280298
58Respiratory failure (HP:0002878)2.00191648
59Lethargy (HP:0001254)2.00076966
60Medial flaring of the eyebrow (HP:0010747)1.99683136
61Palpebral edema (HP:0100540)1.96300632
62Concave nail (HP:0001598)1.95614922
63Abnormality of the phalanges of the 5th finger (HP:0004213)1.95098804
64Aplasia involving bones of the extremities (HP:0009825)1.92441225
65Aplasia involving bones of the upper limbs (HP:0009823)1.92441225
66Aplasia of the phalanges of the hand (HP:0009802)1.92441225
67Optic disc pallor (HP:0000543)1.88487119
683-Methylglutaconic aciduria (HP:0003535)1.88211020
69Pancytopenia (HP:0001876)1.87339092
70Pancreatic cysts (HP:0001737)1.86156062
71Stomach cancer (HP:0012126)1.85482894
72Exercise intolerance (HP:0003546)1.83103707
73Vertebral fusion (HP:0002948)1.81635626
7411 pairs of ribs (HP:0000878)1.80807297
75Sclerocornea (HP:0000647)1.79867812
76Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.76786571
77Increased serum lactate (HP:0002151)1.76437776
78Hypothermia (HP:0002045)1.76286626
79Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.72699306
80Mesomelia (HP:0003027)1.72085582
81Delayed CNS myelination (HP:0002188)1.71301646
82Fused cervical vertebrae (HP:0002949)1.71272898
83Anterior segment dysgenesis (HP:0007700)1.69679163
84True hermaphroditism (HP:0010459)1.69628791
85Ectopic anus (HP:0004397)1.69263205
86Colon cancer (HP:0003003)1.69228094
87Abnormal urine phosphate concentration (HP:0012599)1.68992338
88Broad toe (HP:0001837)1.67782452
89Nasolacrimal duct obstruction (HP:0000579)1.66186734
90Cutaneous finger syndactyly (HP:0010554)1.64875165
91Brushfield spots (HP:0001088)1.64410417
92Hypoplasia of the ulna (HP:0003022)1.63752949
93Median cleft lip (HP:0000161)1.63353710
94Aplasia/hypoplasia of the uterus (HP:0008684)1.62420704
95Small hand (HP:0200055)1.61464057
96X-linked dominant inheritance (HP:0001423)1.59942160
97Abnormal protein glycosylation (HP:0012346)1.59801275
98Abnormal glycosylation (HP:0012345)1.59801275
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.59801275
100Abnormal protein N-linked glycosylation (HP:0012347)1.59801275

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.22902537
2ZAK3.47235301
3EPHB23.37293482
4VRK13.22715235
5TXK2.91609682
6KDR2.76114406
7TLK12.50297295
8TESK22.38924143
9INSRR2.36812246
10BCKDK2.35717173
11NUAK12.14778830
12PASK1.96951569
13SRPK11.79659851
14FGFR21.76702898
15BLK1.68729249
16NME21.62911688
17BRSK21.56193560
18TIE11.53567166
19MUSK1.50375807
20ADRBK21.46253368
21BUB11.45409685
22WEE11.36663117
23PINK11.36532219
24DYRK21.33400387
25PIK3CA1.32783918
26MST41.28129106
27BMPR1B1.24423977
28MAP4K21.21085788
29PNCK1.19116124
30CASK1.18175352
31TAF11.13941426
32NME11.12767467
33TSSK61.11682617
34STK241.08182995
35TRIM281.05269235
36DYRK30.99626850
37CDK80.98484334
38CDK190.95502553
39TAOK10.91946063
40WNK40.91200608
41AURKA0.90392649
42CSNK1G10.88691035
43MAPK150.87732319
44LRRK20.86953530
45WNK30.83917038
46TEC0.81697668
47TESK10.79919571
48PLK30.78522298
49PDK20.76831703
50CSNK1G30.68020601
51MAP2K70.66845692
52GRK60.66511748
53FRK0.64933248
54GRK70.64393644
55CSNK1G20.62769542
56MAPK70.62683890
57AURKB0.61295948
58TGFBR20.60883427
59SYK0.60516706
60HIPK20.60475448
61BCR0.56884047
62CDK40.55849633
63NEK90.54391881
64NEK20.53995352
65CSNK2A20.53576685
66RPS6KA40.52986972
67PRKCQ0.52911843
68ERBB20.52241546
69TAOK30.51554569
70FGFR10.51281519
71TNIK0.50078248
72RPS6KA50.48983170
73IKBKE0.48342766
74LIMK10.48321888
75EPHA20.47846530
76STK30.47781420
77MAP3K40.47472983
78CSK0.44829310
79GRK10.44735682
80BRSK10.42252802
81CSNK2A10.42062173
82PIM10.41003874
83CHEK20.40592187
84ITK0.40328041
85CDK30.39574343
86MAP4K10.37631372
87PRKCE0.37597169
88SIK20.35061182
89CSF1R0.34380269
90JAK30.33123141
91STK160.31922874
92MATK0.31913021
93OBSCN0.31642454
94LYN0.29519330
95KIT0.29305192
96PRKACA0.28105552
97MKNK10.27517891
98CDK90.27385701
99MAPKAPK30.27377301
100ATR0.27117334

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.24868440
2Oxidative phosphorylation_Homo sapiens_hsa001905.48774091
3Proteasome_Homo sapiens_hsa030504.51169948
4Parkinsons disease_Homo sapiens_hsa050124.48815660
5Huntingtons disease_Homo sapiens_hsa050163.40094965
6Alzheimers disease_Homo sapiens_hsa050103.30149691
7Protein export_Homo sapiens_hsa030603.12278027
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.05062243
9Cardiac muscle contraction_Homo sapiens_hsa042602.78232732
10RNA polymerase_Homo sapiens_hsa030202.52566674
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.93473966
12Mismatch repair_Homo sapiens_hsa034301.82301375
13Spliceosome_Homo sapiens_hsa030401.79724276
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52645914
15Antigen processing and presentation_Homo sapiens_hsa046121.47886223
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44059255
17Primary immunodeficiency_Homo sapiens_hsa053401.27262757
18Nitrogen metabolism_Homo sapiens_hsa009101.10634276
19Systemic lupus erythematosus_Homo sapiens_hsa053221.09692305
20Nucleotide excision repair_Homo sapiens_hsa034201.07532466
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04664635
22Vitamin digestion and absorption_Homo sapiens_hsa049771.02913590
23Graft-versus-host disease_Homo sapiens_hsa053321.00211432
24DNA replication_Homo sapiens_hsa030300.99774321
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98127694
26N-Glycan biosynthesis_Homo sapiens_hsa005100.96050971
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91985357
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91371569
29Homologous recombination_Homo sapiens_hsa034400.89427248
30Basal cell carcinoma_Homo sapiens_hsa052170.89390975
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86734528
32Hematopoietic cell lineage_Homo sapiens_hsa046400.84510846
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82010738
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77860983
35Autoimmune thyroid disease_Homo sapiens_hsa053200.77394268
36Purine metabolism_Homo sapiens_hsa002300.76687680
37Peroxisome_Homo sapiens_hsa041460.75895001
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75849497
39Pyrimidine metabolism_Homo sapiens_hsa002400.74051296
40Melanoma_Homo sapiens_hsa052180.72093289
41RNA degradation_Homo sapiens_hsa030180.71302868
42Phototransduction_Homo sapiens_hsa047440.70858374
43Caffeine metabolism_Homo sapiens_hsa002320.69684770
44Chemical carcinogenesis_Homo sapiens_hsa052040.67781461
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67610353
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66024541
47Propanoate metabolism_Homo sapiens_hsa006400.63447310
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61498872
49Rheumatoid arthritis_Homo sapiens_hsa053230.57469971
50RNA transport_Homo sapiens_hsa030130.55469055
51Basal transcription factors_Homo sapiens_hsa030220.55306501
52Linoleic acid metabolism_Homo sapiens_hsa005910.54132825
53Glutathione metabolism_Homo sapiens_hsa004800.50216665
54Hedgehog signaling pathway_Homo sapiens_hsa043400.49270788
55Complement and coagulation cascades_Homo sapiens_hsa046100.48710724
56Allograft rejection_Homo sapiens_hsa053300.48485542
57Fatty acid elongation_Homo sapiens_hsa000620.47622076
58Alcoholism_Homo sapiens_hsa050340.44138786
59Type I diabetes mellitus_Homo sapiens_hsa049400.43976490
60Base excision repair_Homo sapiens_hsa034100.43733517
61Metabolic pathways_Homo sapiens_hsa011000.41970640
62Tryptophan metabolism_Homo sapiens_hsa003800.41835748
63Epstein-Barr virus infection_Homo sapiens_hsa051690.38557489
64Shigellosis_Homo sapiens_hsa051310.37659664
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37621745
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36970029
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36189917
68Retinol metabolism_Homo sapiens_hsa008300.36010239
69Steroid biosynthesis_Homo sapiens_hsa001000.35925744
70Folate biosynthesis_Homo sapiens_hsa007900.35398011
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.34716944
72Pyruvate metabolism_Homo sapiens_hsa006200.34482268
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33467045
74p53 signaling pathway_Homo sapiens_hsa041150.32429760
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29481127
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27413888
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.26929894
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26454063
79T cell receptor signaling pathway_Homo sapiens_hsa046600.25907231
80Starch and sucrose metabolism_Homo sapiens_hsa005000.25647492
81Fat digestion and absorption_Homo sapiens_hsa049750.25053391
82ABC transporters_Homo sapiens_hsa020100.24752548
83Fanconi anemia pathway_Homo sapiens_hsa034600.23481170
84Oocyte meiosis_Homo sapiens_hsa041140.23033670
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22647415
86Regulation of autophagy_Homo sapiens_hsa041400.19672784
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19055599
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18980091
89Asthma_Homo sapiens_hsa053100.18932437
90HTLV-I infection_Homo sapiens_hsa051660.18797121
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.18280793
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18272536
93Mineral absorption_Homo sapiens_hsa049780.17506109
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17350146
95Wnt signaling pathway_Homo sapiens_hsa043100.15948555
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.15916640
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.14668584
98Pathways in cancer_Homo sapiens_hsa052000.13274182
99TGF-beta signaling pathway_Homo sapiens_hsa043500.13104085
100Collecting duct acid secretion_Homo sapiens_hsa049660.11494841

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