PDIA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.49597145
2Golgi transport vesicle coating (GO:0048200)7.49597145
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.11171705
4signal peptide processing (GO:0006465)4.90901513
5activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.88638991
6COPII vesicle coating (GO:0048208)4.84861693
7positive regulation of nuclease activity (GO:0032075)4.75549335
8protein retention in ER lumen (GO:0006621)4.74693964
9endoplasmic reticulum unfolded protein response (GO:0030968)4.45252293
10regulation of nuclease activity (GO:0032069)4.37029756
11cellular response to unfolded protein (GO:0034620)4.29698539
12ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.29349314
13ER-nucleus signaling pathway (GO:0006984)4.16445492
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.15058028
15L-phenylalanine catabolic process (GO:0006559)4.15058028
16cellular response to topologically incorrect protein (GO:0035967)4.08614612
17sequestering of metal ion (GO:0051238)4.07852463
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.05416509
19L-phenylalanine metabolic process (GO:0006558)4.05416509
20retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.99869760
21negative regulation of fibrinolysis (GO:0051918)3.87247692
22nuclear pore complex assembly (GO:0051292)3.87019282
234-hydroxyproline metabolic process (GO:0019471)3.86452077
24apoptotic cell clearance (GO:0043277)3.81920269
25DNA unwinding involved in DNA replication (GO:0006268)3.79852321
26sulfur amino acid catabolic process (GO:0000098)3.74113208
27protein carboxylation (GO:0018214)3.72436632
28peptidyl-glutamic acid carboxylation (GO:0017187)3.72436632
29complement activation, classical pathway (GO:0006958)3.68302786
30hemidesmosome assembly (GO:0031581)3.65277872
31basement membrane organization (GO:0071711)3.58082980
32* response to endoplasmic reticulum stress (GO:0034976)3.56975713
33peptidyl-proline hydroxylation (GO:0019511)3.54599659
34exocrine pancreas development (GO:0031017)3.51491317
35folic acid-containing compound biosynthetic process (GO:0009396)3.51252280
36aromatic amino acid family catabolic process (GO:0009074)3.47745109
37regulation of protein activation cascade (GO:2000257)3.45084161
38complement activation, alternative pathway (GO:0006957)3.44858939
39protein N-linked glycosylation via asparagine (GO:0018279)3.44247347
40cell adhesion mediated by integrin (GO:0033627)3.44058748
41glyoxylate metabolic process (GO:0046487)3.43650425
42alpha-linolenic acid metabolic process (GO:0036109)3.42960685
43peptidyl-asparagine modification (GO:0018196)3.42081315
44UDP-N-acetylglucosamine metabolic process (GO:0006047)3.41022165
45regulation of fibrinolysis (GO:0051917)3.35760734
46complement activation (GO:0006956)3.35291014
47mitotic chromosome condensation (GO:0007076)3.34873922
48regulation of complement activation (GO:0030449)3.30650301
49antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.30497330
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.30497330
51response to unfolded protein (GO:0006986)3.29972003
52nuclear pore organization (GO:0006999)3.23851501
53proline biosynthetic process (GO:0006561)3.20101605
54response to topologically incorrect protein (GO:0035966)3.19971306
55vesicle coating (GO:0006901)3.18646760
56skin morphogenesis (GO:0043589)3.16466635
57very-low-density lipoprotein particle assembly (GO:0034379)3.16293610
58triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.16070522
59protein N-linked glycosylation (GO:0006487)3.15388337
60protein hydroxylation (GO:0018126)3.15205116
61nucleotide-sugar biosynthetic process (GO:0009226)3.14143800
62high-density lipoprotein particle remodeling (GO:0034375)3.09962922
63antigen processing and presentation of endogenous antigen (GO:0019883)3.09015144
64valine metabolic process (GO:0006573)3.06272713
65tyrosine metabolic process (GO:0006570)3.05688694
66serine family amino acid biosynthetic process (GO:0009070)3.05194865
67glycine metabolic process (GO:0006544)3.05043858
68ER overload response (GO:0006983)3.03798034
69desmosome organization (GO:0002934)3.01161084
70tryptophan metabolic process (GO:0006568)3.00020960
71protein maturation by protein folding (GO:0022417)2.96375079
72tetrahydrofolate metabolic process (GO:0046653)2.93128397
73kynurenine metabolic process (GO:0070189)2.92750394
74pentose-phosphate shunt (GO:0006098)2.90977607
75indole-containing compound catabolic process (GO:0042436)2.90927544
76indolalkylamine catabolic process (GO:0046218)2.90927544
77tryptophan catabolic process (GO:0006569)2.90927544
78reverse cholesterol transport (GO:0043691)2.90103387
79bile acid biosynthetic process (GO:0006699)2.89249536
80protein autoprocessing (GO:0016540)2.88048877
81NADPH regeneration (GO:0006740)2.87420565
82urea cycle (GO:0000050)2.86828865
83urea metabolic process (GO:0019627)2.86828865
84gap junction assembly (GO:0016264)2.85490672
85pore complex assembly (GO:0046931)2.85480424
86protein localization to endosome (GO:0036010)2.84461426
87homocysteine metabolic process (GO:0050667)2.83790686
88cysteine metabolic process (GO:0006534)2.82893852
89cell-substrate junction assembly (GO:0007044)2.82835287
90glucose 6-phosphate metabolic process (GO:0051156)2.82728579
91cellular modified amino acid catabolic process (GO:0042219)2.79733712
92regulation of cholesterol biosynthetic process (GO:0045540)2.78038531
93glucose catabolic process (GO:0006007)2.77766633
94fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.77360141
95planar cell polarity pathway involved in neural tube closure (GO:0090179)2.77156452
96L-serine metabolic process (GO:0006563)2.76899708
97lysine metabolic process (GO:0006553)2.76002947
98lysine catabolic process (GO:0006554)2.76002947
99maternal placenta development (GO:0001893)2.75802477
100protein activation cascade (GO:0072376)2.75479344
101establishment of integrated proviral latency (GO:0075713)2.71673857
102plasma lipoprotein particle assembly (GO:0034377)2.70386667
103protein-lipid complex remodeling (GO:0034368)2.67881173
104macromolecular complex remodeling (GO:0034367)2.67881173
105plasma lipoprotein particle remodeling (GO:0034369)2.67881173
106lipoprotein metabolic process (GO:0042157)2.67441569
107endothelial cell morphogenesis (GO:0001886)2.67139513
108aromatic amino acid family metabolic process (GO:0009072)2.65363160
109serine family amino acid metabolic process (GO:0009069)2.63638075
110regulation of glucose import in response to insulin stimulus (GO:2001273)2.63391369
111glutamine family amino acid biosynthetic process (GO:0009084)2.63144880
112protein complex localization (GO:0031503)2.61397172
113regulation of mammary gland epithelial cell proliferation (GO:0033599)2.61305146
114regulation of cholesterol homeostasis (GO:2000188)2.60395306
115negative regulation of cholesterol transport (GO:0032375)2.58975470
116negative regulation of sterol transport (GO:0032372)2.58975470
117heterochromatin organization (GO:0070828)2.58488369
118regulation of plasminogen activation (GO:0010755)2.58433313
119endodermal cell differentiation (GO:0035987)2.57690875
120pinocytosis (GO:0006907)2.56393202
121pteridine-containing compound biosynthetic process (GO:0042559)2.56293795
122nitrogen cycle metabolic process (GO:0071941)2.55980642
123negative regulation of fatty acid biosynthetic process (GO:0045717)2.55571553
124adherens junction assembly (GO:0034333)2.55509451
125regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.55377493
126nucleobase-containing small molecule interconversion (GO:0015949)2.53763833
127bile acid metabolic process (GO:0008206)2.53425549
128proline metabolic process (GO:0006560)2.52731080
129regulation of translational termination (GO:0006449)2.52581772
130regulation of translational fidelity (GO:0006450)2.51939896
131epithelial cell-cell adhesion (GO:0090136)2.51468452
132one-carbon metabolic process (GO:0006730)2.50811633
133cellular protein complex localization (GO:0034629)2.50444605
134cellular copper ion homeostasis (GO:0006878)2.50221457
135establishment of apical/basal cell polarity (GO:0035089)2.49898273
136peptide catabolic process (GO:0043171)2.49479464
137serine family amino acid catabolic process (GO:0009071)2.49354293
138cell-substrate adherens junction assembly (GO:0007045)2.49020075
139focal adhesion assembly (GO:0048041)2.49020075
140regulation of lipoprotein particle clearance (GO:0010984)2.48971663
141protein-lipid complex assembly (GO:0065005)2.47940024
142positive regulation of hormone biosynthetic process (GO:0046886)2.47875388
143bundle of His cell to Purkinje myocyte communication (GO:0086069)2.47676967
144plasma lipoprotein particle clearance (GO:0034381)2.47603654
145fibrinolysis (GO:0042730)2.46391221
146regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.45471984
147formation of translation preinitiation complex (GO:0001731)2.44957854
148DNA strand elongation involved in DNA replication (GO:0006271)2.43223235
149membrane protein ectodomain proteolysis (GO:0006509)2.42463646
150regulation of apoptotic cell clearance (GO:2000425)2.40063353
151mitotic sister chromatid segregation (GO:0000070)2.39890453
152G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.39743378
153glucocorticoid receptor signaling pathway (GO:0042921)2.37885755
154positive regulation of hormone metabolic process (GO:0032352)2.37546107
155spliceosomal tri-snRNP complex assembly (GO:0000244)2.37348735
156DNA strand elongation (GO:0022616)2.37293990
157peptidyl-arginine omega-N-methylation (GO:0035247)2.37160424
158branching involved in mammary gland duct morphogenesis (GO:0060444)2.36790811
159ribosome assembly (GO:0042255)2.36249932
160long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.35227343
161protein localization to chromosome, centromeric region (GO:0071459)2.34768530
162GDP-mannose metabolic process (GO:0019673)2.33286980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.71310302
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.46901164
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.83274395
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.63847764
5E2F7_22180533_ChIP-Seq_HELA_Human3.09722798
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.99902685
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.90077706
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.88693868
9ZNF263_19887448_ChIP-Seq_K562_Human2.85508415
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.65113567
11* CLOCK_20551151_ChIP-Seq_293T_Human2.64504952
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.55970550
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.51991476
14* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32385060
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27398104
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13929812
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93758567
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88259004
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.86602933
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.83829922
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.80202427
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76016625
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.74741282
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74679254
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.73610052
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.72626304
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.72205249
28MYC_22102868_ChIP-Seq_BL_Human1.70943390
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70538928
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69330880
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.63943098
32RACK7_27058665_Chip-Seq_MCF-7_Human1.62443748
33GATA1_22025678_ChIP-Seq_K562_Human1.62378337
34KLF4_18555785_ChIP-Seq_MESCs_Mouse1.61158319
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56974669
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.54025251
37AR_21909140_ChIP-Seq_LNCAP_Human1.53398713
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50736706
39KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49985214
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49489202
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48843808
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48570336
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.47321453
44CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45618365
45DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44135347
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.43243868
47TFEB_21752829_ChIP-Seq_HELA_Human1.43196192
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43159597
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42388229
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40013643
51LXR_22292898_ChIP-Seq_THP-1_Human1.36215118
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33590548
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32534096
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31510419
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31454986
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30869026
57SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30622588
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.29971392
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29930607
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29369925
61* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29168016
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27361927
63CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26601811
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26548856
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25809418
66SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.25535581
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23957582
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23729325
69DCP1A_22483619_ChIP-Seq_HELA_Human1.22886220
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22512380
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22117463
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21791980
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21578664
74* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21434293
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19183619
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.19076447
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.17796256
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.17375839
79* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16892703
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16312024
81* KDM5A_27292631_Chip-Seq_BREAST_Human1.15471276
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14706566
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14618672
84ELK1_19687146_ChIP-ChIP_HELA_Human1.14175859
85EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12176993
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11172469
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11028348
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11028348
89* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10811099
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10756734
91NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09681486
92* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09475811
93MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09077652
94UBF1/2_26484160_Chip-Seq_HMECs_Human1.07881396
95NANOG_21062744_ChIP-ChIP_HESCs_Human1.07241298
96ESR1_21235772_ChIP-Seq_MCF-7_Human1.06869660
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06776031
98ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06715437
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05172413
100VDR_21846776_ChIP-Seq_THP-1_Human1.03865562
101THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03695578
102E2F1_21310950_ChIP-Seq_MCF-7_Human1.03677296
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03490413
104GABP_19822575_ChIP-Seq_HepG2_Human1.03262043
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03146009
106* CHD1_26751641_Chip-Seq_LNCaP_Human1.02806594
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02790583
108JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02492548
109XRN2_22483619_ChIP-Seq_HELA_Human1.01946314
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01413470
111MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01364041
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01337418
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01119646
114BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01094955
115GATA4_25053715_ChIP-Seq_YYC3_Human1.00974177
116GATA6_25053715_ChIP-Seq_YYC3_Human1.00611829
117ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00337489
118PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00089676
119TP53_22127205_ChIP-Seq_IMR90_Human0.99967882
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99792597
121TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99457375
122TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99321635
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98955862
124ETS1_20019798_ChIP-Seq_JURKAT_Human0.98857766
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97592545
126E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97585705
127* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.96975595
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95723213
129HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95574755
130MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95298109
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95293636
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93855229
133* SOX17_20123909_ChIP-Seq_XEN_Mouse0.91191301
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90177517
135MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90109120
136VDR_23849224_ChIP-Seq_CD4+_Human0.89999824
137ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88689554
138RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88052517
139ATF3_27146783_Chip-Seq_COLON_Human0.87937125
140FOXP3_21729870_ChIP-Seq_TREG_Human0.87873268
141NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87638474
142KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85436344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.36324079
2MP0008438_abnormal_cutaneous_collagen3.64830747
3MP0005365_abnormal_bile_salt3.26976700
4MP0005360_urolithiasis3.20468343
5MP0003705_abnormal_hypodermis_morpholog2.64742558
6MP0003806_abnormal_nucleotide_metabolis2.63478250
7MP0005085_abnormal_gallbladder_physiolo2.59346187
8MP0006054_spinal_hemorrhage2.46495735
9MP0003252_abnormal_bile_duct2.36331664
10MP0003941_abnormal_skin_development2.09961813
11MP0003300_gastrointestinal_ulcer2.05503471
12MP0005220_abnormal_exocrine_pancreas2.04123350
13MP0010234_abnormal_vibrissa_follicle1.98617753
14MP0005451_abnormal_body_composition1.96700148
15MP0004858_abnormal_nervous_system1.96503824
16MP0004264_abnormal_extraembryonic_tissu1.93467337
17MP0003195_calcinosis1.92883846
18MP0001849_ear_inflammation1.87595199
19MP0005623_abnormal_meninges_morphology1.86105651
20MP0003111_abnormal_nucleus_morphology1.85548798
21MP0010352_gastrointestinal_tract_polyps1.84264106
22MP0004233_abnormal_muscle_weight1.81115349
23MP0001666_abnormal_nutrient_absorption1.79665906
24MP0009840_abnormal_foam_cell1.76006722
25MP0008875_abnormal_xenobiotic_pharmacok1.75523338
26MP0010329_abnormal_lipoprotein_level1.70218326
27MP0005275_abnormal_skin_tensile1.69959064
28MP0010030_abnormal_orbit_morphology1.69827951
29MP0008932_abnormal_embryonic_tissue1.66946106
30MP0002877_abnormal_melanocyte_morpholog1.63984408
31MP0002089_abnormal_postnatal_growth/wei1.55435072
32MP0003566_abnormal_cell_adhesion1.53252137
33MP0005058_abnormal_lysosome_morphology1.50116716
34MP0005408_hypopigmentation1.47340232
35MP0005023_abnormal_wound_healing1.45564478
36MP0005083_abnormal_biliary_tract1.45517924
37MP0000609_abnormal_liver_physiology1.44295670
38MP0009384_cardiac_valve_regurgitation1.42169998
39MP0009643_abnormal_urine_homeostasis1.38519137
40MP0005332_abnormal_amino_acid1.33903708
41MP0004185_abnormal_adipocyte_glucose1.33753306
42MP0003693_abnormal_embryo_hatching1.32540645
43MP0010094_abnormal_chromosome_stability1.32356135
44MP0005076_abnormal_cell_differentiation1.32096074
45MP0002166_altered_tumor_susceptibility1.31828461
46MP0000762_abnormal_tongue_morphology1.31589225
47MP0002796_impaired_skin_barrier1.31484402
48MP0003077_abnormal_cell_cycle1.29610300
49MP0001672_abnormal_embryogenesis/_devel1.29545831
50MP0005380_embryogenesis_phenotype1.29545831
51MP0000566_synostosis1.29490399
52MP0001944_abnormal_pancreas_morphology1.28725503
53MP0004272_abnormal_basement_membrane1.26916863
54MP0003315_abnormal_perineum_morphology1.25659331
55MP0003984_embryonic_growth_retardation1.25519438
56MP0009053_abnormal_anal_canal1.22876428
57MP0003091_abnormal_cell_migration1.21481698
58MP0003868_abnormal_feces_composition1.21010652
59MP0003453_abnormal_keratinocyte_physiol1.19662453
60MP0003283_abnormal_digestive_organ1.19124572
61MP0002080_prenatal_lethality1.19022243
62MP0005501_abnormal_skin_physiology1.18919525
63MP0002088_abnormal_embryonic_growth/wei1.18287848
64MP0000350_abnormal_cell_proliferation1.17992537
65MP0003191_abnormal_cellular_cholesterol1.17196160
66MP0003385_abnormal_body_wall1.15792236
67MP0002138_abnormal_hepatobiliary_system1.13593904
68MP0002697_abnormal_eye_size1.12589619
69MP0005503_abnormal_tendon_morphology1.12123229
70MP0002060_abnormal_skin_morphology1.11012482
71MP0009697_abnormal_copulation1.07529004
72MP0001697_abnormal_embryo_size1.07466591
73MP0008260_abnormal_autophagy1.07317463
74MP0000467_abnormal_esophagus_morphology1.06904096
75MP0005319_abnormal_enzyme/_coenzyme1.06818325
76MP0000598_abnormal_liver_morphology1.06380974
77MP0002084_abnormal_developmental_patter1.06085971
78MP0002085_abnormal_embryonic_tissue1.04040049
79MP0003183_abnormal_peptide_metabolism1.02319974
80MP0002896_abnormal_bone_mineralization1.00891207
81MP0001216_abnormal_epidermal_layer1.00454583
82MP0003950_abnormal_plasma_membrane0.99627948
83MP0005409_darkened_coat_color0.98942624
84MP0002295_abnormal_pulmonary_circulatio0.98554197
85MP0000678_abnormal_parathyroid_gland0.98281468
86MP0000579_abnormal_nail_morphology0.98067395
87MP0002928_abnormal_bile_duct0.97280116
88MP0005621_abnormal_cell_physiology0.96681861
89MP0003186_abnormal_redox_activity0.96067658
90MP0005197_abnormal_uvea_morphology0.93585946
91MP0005647_abnormal_sex_gland0.93371814
92MP0000013_abnormal_adipose_tissue0.92546084
93MP0003115_abnormal_respiratory_system0.91187544
94MP0005257_abnormal_intraocular_pressure0.90553844
95MP0002693_abnormal_pancreas_physiology0.90177440
96MP0002118_abnormal_lipid_homeostasis0.89799901
97MP0003942_abnormal_urinary_system0.89378050
98MP0003123_paternal_imprinting0.88609859
99MP0004957_abnormal_blastocyst_morpholog0.88522805
100MP0001756_abnormal_urination0.87573906
101MP0002092_abnormal_eye_morphology0.85224484
102MP0000627_abnormal_mammary_gland0.83999130
103MP0000534_abnormal_ureter_morphology0.83652963
104MP0002098_abnormal_vibrissa_morphology0.83252005
105MP0003279_aneurysm0.82238830
106MP0001661_extended_life_span0.81255603
107MP0001243_abnormal_dermal_layer0.81083169
108MP0000428_abnormal_craniofacial_morphol0.80570266
109MP0005384_cellular_phenotype0.79330922
110MP0000462_abnormal_digestive_system0.77533848
111MP0000613_abnormal_salivary_gland0.76781589
112MP0001835_abnormal_antigen_presentation0.76616889
113MP0010307_abnormal_tumor_latency0.76398782
114MP0001881_abnormal_mammary_gland0.75960713
115MP0003890_abnormal_embryonic-extraembry0.75832710
116MP0000733_abnormal_muscle_development0.75467404
117MP0004197_abnormal_fetal_growth/weight/0.75130409
118MP0000432_abnormal_head_morphology0.74082544
119MP0002168_other_aberrant_phenotype0.73899064
120MP0010678_abnormal_skin_adnexa0.73890224
121MP0000377_abnormal_hair_follicle0.73155520
122MP0000767_abnormal_smooth_muscle0.72700498
123MP0010368_abnormal_lymphatic_system0.72533844
124MP0001958_emphysema0.72191331
125MP0000537_abnormal_urethra_morphology0.72066433
126MP0002006_tumorigenesis0.71896883
127MP0000003_abnormal_adipose_tissue0.71209020
128MP0005636_abnormal_mineral_homeostasis0.70357389
129MP0002136_abnormal_kidney_physiology0.70153100
130MP0003795_abnormal_bone_structure0.70080823
131MP0002078_abnormal_glucose_homeostasis0.69614148
132MP0002135_abnormal_kidney_morphology0.69539475
133MP0004782_abnormal_surfactant_physiolog0.68691980
134MP0001845_abnormal_inflammatory_respons0.67539266
135MP0001764_abnormal_homeostasis0.67278053
136MP0003436_decreased_susceptibility_to0.65728339
137MP0000685_abnormal_immune_system0.65400112
138MP0001533_abnormal_skeleton_physiology0.64527099
139MP0008469_abnormal_protein_level0.63873927
140MP0009763_increased_sensitivity_to0.63770322
141MP0003172_abnormal_lysosome_physiology0.62411686
142MP0004947_skin_inflammation0.61817594
143MP0000371_diluted_coat_color0.61085555
144MP0001915_intracranial_hemorrhage0.60312846
145MP0009672_abnormal_birth_weight0.59871671
146MP0005508_abnormal_skeleton_morphology0.59435655
147MP0004043_abnormal_pH_regulation0.59355287
148MP0002933_joint_inflammation0.58984182
149MP0000858_altered_metastatic_potential0.58293089
150MP0001730_embryonic_growth_arrest0.58098249
151MP0002111_abnormal_tail_morphology0.57863232
152MP0000163_abnormal_cartilage_morphology0.57531244
153MP0000477_abnormal_intestine_morphology0.57288288
154MP0004019_abnormal_vitamin_homeostasis0.57243023
155MP0008007_abnormal_cellular_replicative0.56806385
156MP0002086_abnormal_extraembryonic_tissu0.56706667
157MP0009642_abnormal_blood_homeostasis0.55297803

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the intrinsic pathway (HP:0010989)4.32086719
2Hypoglycemic coma (HP:0001325)4.28048812
3Deep venous thrombosis (HP:0002625)4.15063896
4Intrahepatic cholestasis (HP:0001406)4.14889166
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.14488184
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.13473515
7Abnormality of the common coagulation pathway (HP:0010990)3.88844419
8Xanthomatosis (HP:0000991)3.63143671
9Hypobetalipoproteinemia (HP:0003563)3.44332684
10Hypoglycemic seizures (HP:0002173)3.42111960
11Complement deficiency (HP:0004431)3.33489844
12Protrusio acetabuli (HP:0003179)3.33130800
13Prolonged partial thromboplastin time (HP:0003645)3.27734234
14Hyperinsulinemic hypoglycemia (HP:0000825)3.25964890
15Flat acetabular roof (HP:0003180)3.11648547
16Premature rupture of membranes (HP:0001788)3.11571955
17Abnormality of endocrine pancreas physiology (HP:0012093)2.91991941
18Abnormality of the pancreatic islet cells (HP:0006476)2.91991941
19Hyperacusis (HP:0010780)2.87806845
20Ketoacidosis (HP:0001993)2.86612402
21Ketosis (HP:0001946)2.85506476
22Abnormality of carpal bone ossification (HP:0006257)2.85290316
23Cervical subluxation (HP:0003308)2.77618375
24Atrophic scars (HP:0001075)2.70648462
25Abnormality of complement system (HP:0005339)2.66047761
26Fat malabsorption (HP:0002630)2.63128073
27Vacuolated lymphocytes (HP:0001922)2.57549891
28Hypolipoproteinemia (HP:0010981)2.56721423
29Back pain (HP:0003418)2.51681977
30Abnormality of the Achilles tendon (HP:0005109)2.51123706
31Urinary glycosaminoglycan excretion (HP:0003541)2.48489828
32Mucopolysacchariduria (HP:0008155)2.48489828
33Pancreatic islet-cell hyperplasia (HP:0004510)2.47658180
34Achilles tendon contracture (HP:0001771)2.44011421
35Abnormality of sulfur amino acid metabolism (HP:0004339)2.43938050
36Abnormal ossification of hand bones (HP:0005921)2.43870124
37Asymmetry of the thorax (HP:0001555)2.43827921
38Symptomatic seizures (HP:0011145)2.41222100
39Short nail (HP:0001799)2.40739530
40Small epiphyses (HP:0010585)2.37152299
41Hepatocellular carcinoma (HP:0001402)2.35558125
42Hyperlipoproteinemia (HP:0010980)2.35386388
43Aortic dissection (HP:0002647)2.35169020
44Arterial tortuosity (HP:0005116)2.34886169
45Abnormality of the acetabulum (HP:0003170)2.34739998
46Spastic diplegia (HP:0001264)2.34668712
47Hyperglycemia (HP:0003074)2.33216226
48Aortic aneurysm (HP:0004942)2.33171003
49Late onset (HP:0003584)2.31530583
50Shallow orbits (HP:0000586)2.31231582
51Conjugated hyperbilirubinemia (HP:0002908)2.29853690
52Mitral stenosis (HP:0001718)2.29557145
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.29327517
54Hyperammonemia (HP:0001987)2.28532991
55Ankyloglossia (HP:0010296)2.28383216
56Trismus (HP:0000211)2.26936038
57Myocardial infarction (HP:0001658)2.26905801
58Nonimmune hydrops fetalis (HP:0001790)2.25952924
59Selective tooth agenesis (HP:0001592)2.25462184
60Thrombocytosis (HP:0001894)2.25360066
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.24876601
62Thoracolumbar scoliosis (HP:0002944)2.23648838
63Abnormal gallbladder physiology (HP:0012438)2.23355631
64Cholecystitis (HP:0001082)2.23355631
65Dysostosis multiplex (HP:0000943)2.23233954
66Fragile skin (HP:0001030)2.22938909
67Abnormality of the distal phalanges of the toes (HP:0010182)2.22932903
68Deviation of the thumb (HP:0009603)2.21877502
69Pterygium (HP:0001059)2.21544317
70Joint hemorrhage (HP:0005261)2.20556416
71Abnormal delivery (HP:0001787)2.19886249
72Insomnia (HP:0100785)2.19066036
73Osteolytic defects of the hand bones (HP:0009699)2.18896501
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.18896501
75Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.18582712
76Ankle contracture (HP:0006466)2.18514282
77Renal duplication (HP:0000075)2.18017073
78Abnormal cartilage morphology (HP:0002763)2.17771354
79Bladder diverticulum (HP:0000015)2.16882903
80Cerebral aneurysm (HP:0004944)2.16734109
81Generalized aminoaciduria (HP:0002909)2.16473969
82Broad face (HP:0000283)2.15611460
83Abnormality of oral frenula (HP:0000190)2.15110904
84Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13128447
85Hypoalphalipoproteinemia (HP:0003233)2.11709308
86Blue sclerae (HP:0000592)2.11056364
87Vascular tortuosity (HP:0004948)2.10985976
88Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10152870
89Abnormality of polysaccharide metabolism (HP:0011012)2.10152870
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10152870
91Peritonitis (HP:0002586)2.08822238
92Systemic lupus erythematosus (HP:0002725)2.08695539
93Abnormal foot bone ossification (HP:0010675)2.08526349
94Upper limb amyotrophy (HP:0009129)2.06055120
95Distal upper limb amyotrophy (HP:0007149)2.06055120
96Advanced eruption of teeth (HP:0006288)2.02829074
97Natal tooth (HP:0000695)2.02092029
98Skin nodule (HP:0200036)2.01939747
99Abnormality of pyrimidine metabolism (HP:0004353)2.01630555
100Elbow flexion contracture (HP:0002987)2.00846064
101Abdominal distention (HP:0003270)1.97499337
102Abnormal hand bone ossification (HP:0010660)1.97358597
103Abnormality of fatty-acid metabolism (HP:0004359)1.96297706
104Abnormality of methionine metabolism (HP:0010901)1.95681212
105Epidermoid cyst (HP:0200040)1.95227529
106Disproportionate tall stature (HP:0001519)1.93751966
107Protuberant abdomen (HP:0001538)1.92955672
108Ectopia lentis (HP:0001083)1.91511277
109Breech presentation (HP:0001623)1.90714856
110Hypercholesterolemia (HP:0003124)1.90705572
111Hemorrhage of the eye (HP:0011885)1.89874062
112Aneurysm (HP:0002617)1.89854241
113Steatorrhea (HP:0002570)1.89745021
114Soft skin (HP:0000977)1.89488587
115Abnormality of the umbilical cord (HP:0010881)1.88945525
116Hand muscle atrophy (HP:0009130)1.88177972
117Abnormal enzyme/coenzyme activity (HP:0012379)1.87298440
118Glomerulonephritis (HP:0000099)1.86314593
119Increased nuchal translucency (HP:0010880)1.86241413
120Hyperglycinuria (HP:0003108)1.85619279
121Proximal placement of thumb (HP:0009623)1.84630379
122Coxa vara (HP:0002812)1.83858711
123Abnormality of glycolysis (HP:0004366)1.83849486
124Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82666190
125Right ventricular cardiomyopathy (HP:0011663)1.82038187
126Beaking of vertebral bodies (HP:0004568)1.79911837
127Abnormality of nucleobase metabolism (HP:0010932)1.79126242
128Insulin resistance (HP:0000855)1.79071579
129Abnormality of alkaline phosphatase activity (HP:0004379)1.78555022
130Abnormality of serine family amino acid metabolism (HP:0010894)1.77355130
131Abnormality of glycine metabolism (HP:0010895)1.77355130
132Elevated alkaline phosphatase (HP:0003155)1.76712297
133Abnormality of the distal phalanx of the thumb (HP:0009617)1.76465620
134Microglossia (HP:0000171)1.75748155
135Vascular calcification (HP:0004934)1.75048786
136Hyperglycinemia (HP:0002154)1.74684855
137Recurrent gram-negative bacterial infections (HP:0005420)1.74352947
138Hyperbilirubinemia (HP:0002904)1.74351633
139Premature skin wrinkling (HP:0100678)1.74319416
140Orthostatic hypotension (HP:0001278)1.73236820
141Overlapping toe (HP:0001845)1.73194106
142Absent epiphyses (HP:0010577)1.71636770
143Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71636770
144Spinal rigidity (HP:0003306)1.70873367
145Neonatal death (HP:0003811)1.70672261
146Enlarged kidneys (HP:0000105)1.70402506
147Midface retrusion (HP:0011800)1.69755518
148Cardiovascular calcification (HP:0011915)1.69393681
149Abnormal tarsal ossification (HP:0008369)1.68722093
150Abnormality of purine metabolism (HP:0004352)1.67874085
151Arnold-Chiari malformation (HP:0002308)1.67742216
152Long palpebral fissure (HP:0000637)1.67553392
153Abnormalities of placenta or umbilical cord (HP:0001194)1.66672645
154Abnormality of dentin (HP:0010299)1.65970894
155Neonatal short-limb short stature (HP:0008921)1.65390737
156Ulnar bowing (HP:0003031)1.65168639
157Abnormality of pain sensation (HP:0010832)1.65056050
158Impaired pain sensation (HP:0007328)1.65056050
159Flattened epiphyses (HP:0003071)1.63769392
160Mitral valve prolapse (HP:0001634)1.63529609
161Biconcave vertebral bodies (HP:0004586)1.63468568
162Vertebral compression fractures (HP:0002953)1.62385110
163Overriding aorta (HP:0002623)1.62052710
164Subacute progressive viral hepatitis (HP:0006572)1.60615561
165Vertebral hypoplasia (HP:0008417)1.60292853
166Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.60292853
167Abnormality of transition element cation homeostasis (HP:0011030)1.59015708
168Wormian bones (HP:0002645)1.58303387
169Dilatation of the ascending aorta (HP:0005111)1.57039291
170Reduced antithrombin III activity (HP:0001976)1.56427796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.79459511
2SMG13.39653768
3SIK12.83922152
4PASK2.81612893
5BCKDK2.79351912
6FRK2.64064347
7SCYL22.59826346
8FLT32.50804268
9ICK2.50638308
10PKN22.46154922
11TAOK32.39626482
12TRIB32.38538059
13EIF2AK32.11370474
14LATS11.87133158
15FGFR41.82351425
16LATS21.81732741
17TTK1.75591607
18EEF2K1.72005917
19PDGFRA1.70043385
20CAMK1D1.68979029
21INSRR1.66426563
22MAP3K101.64355655
23PTK61.62438235
24EPHA21.61936677
25MET1.56143849
26NTRK11.53556134
27LRRK21.50494175
28PBK1.48879746
29NEK11.45433860
30LMTK21.43899271
31STK101.40242876
32EPHA31.39823518
33ARAF1.37276643
34TESK21.32092628
35TYK21.30513748
36CAMK1G1.27634796
37DDR21.25605604
38MST1R1.22635227
39SRPK11.22052389
40TTN1.17465539
41CSF1R1.12741800
42MAPK151.12540005
43RPS6KA41.09805147
44PIK3CG1.05981841
45VRK21.05609188
46MAP4K11.04723194
47JAK11.04691070
48PAK41.03631162
49TESK11.02942541
50NEK91.01420826
51KDR0.96368848
52RPS6KB20.93901651
53MAP3K80.93575719
54PAK20.93100586
55PIM20.91412486
56BRSK20.85946354
57DYRK1B0.85849002
58TGFBR20.85843547
59PTK20.85550625
60TGFBR10.85313556
61LIMK10.85196597
62JAK30.85143227
63EPHB10.82603238
64MTOR0.78974382
65MAP3K30.74531845
66HIPK20.72764089
67BTK0.72028293
68RIPK10.70512443
69STK30.70449554
70BRAF0.69643057
71NME20.69484165
72FGFR30.68865266
73MST40.68239786
74BUB10.67345608
75EPHB20.67174581
76PRPF4B0.66434413
77MAPK110.65938680
78AURKA0.65877509
79BRSK10.65066185
80MAP2K30.64558817
81TBK10.64126201
82CHEK20.63748071
83CDK60.63257365
84ZAP700.62767059
85FGFR20.62516071
86NEK20.62344186
87CHEK10.60854261
88CDK80.60101735
89WEE10.59728098
90DYRK30.58817390
91ITK0.57630317
92ERBB40.57451718
93MAPKAPK30.57369049
94AKT30.56527454
95JAK20.55703361
96ILK0.54755426
97MOS0.53953588
98FGFR10.53757432
99KIT0.53347320
100EIF2AK10.52132259
101CLK10.51521414
102CDK90.51433800
103BLK0.51388939
104KSR20.50645959
105CDK70.49401943
106TSSK60.49193604
107CSK0.48210642
108AURKB0.47912891
109CHUK0.47607552
110PDGFRB0.47077658
111FER0.46372815
112TAF10.45437045
113GSK3A0.45030199
114MAP2K20.44357372
115MAP3K20.43811417
116CDK40.43685405
117PRKG20.42653886
118PIM10.41553295
119AKT20.41462263
120PLK10.40506540
121PRKCI0.40254413
122CDC70.39941867
123TRPM70.39333135
124ATR0.39269529
125PRKD20.38340238
126IGF1R0.38135752
127BMX0.37945516
128LYN0.37776121
129GRK60.36799340
130PLK30.36402242
131BRD40.36158074
132MAP3K90.34860613
133TAOK10.34837500
134INSR0.34812860
135IRAK30.33994104
136CDK150.33490392
137CDK10.33388060
138MELK0.32501802
139CDK120.32271388
140ACVR1B0.31837243
141CDK11A0.31618871
142CDK180.31388948

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.85620039
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.40900870
3* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.18755193
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.71595027
5Selenocompound metabolism_Homo sapiens_hsa004502.42463714
6Sulfur metabolism_Homo sapiens_hsa009202.38570874
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.37561792
8Complement and coagulation cascades_Homo sapiens_hsa046102.18236337
9Tryptophan metabolism_Homo sapiens_hsa003802.11847540
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96116434
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95012911
12One carbon pool by folate_Homo sapiens_hsa006701.93381708
13Fatty acid degradation_Homo sapiens_hsa000711.89310253
14N-Glycan biosynthesis_Homo sapiens_hsa005101.88022383
15Nitrogen metabolism_Homo sapiens_hsa009101.78520639
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68847038
17Folate biosynthesis_Homo sapiens_hsa007901.68487601
18Fatty acid biosynthesis_Homo sapiens_hsa000611.64339691
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.61806360
20Arginine biosynthesis_Homo sapiens_hsa002201.60563442
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57237758
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.50218943
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.45202822
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38441258
25Histidine metabolism_Homo sapiens_hsa003401.36275641
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34171906
27Antigen processing and presentation_Homo sapiens_hsa046121.31308510
28Staphylococcus aureus infection_Homo sapiens_hsa051501.30777135
29Peroxisome_Homo sapiens_hsa041461.26379176
30Vitamin B6 metabolism_Homo sapiens_hsa007501.25484823
31Fatty acid metabolism_Homo sapiens_hsa012121.24548529
32Biosynthesis of amino acids_Homo sapiens_hsa012301.21542543
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19877933
34Cell cycle_Homo sapiens_hsa041101.17282114
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15952307
36Starch and sucrose metabolism_Homo sapiens_hsa005001.13601383
37Tyrosine metabolism_Homo sapiens_hsa003501.13057814
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12500218
39Fat digestion and absorption_Homo sapiens_hsa049751.10212754
40Other glycan degradation_Homo sapiens_hsa005111.09800234
41Chemical carcinogenesis_Homo sapiens_hsa052041.08304543
42Propanoate metabolism_Homo sapiens_hsa006401.07224709
43Phenylalanine metabolism_Homo sapiens_hsa003601.05204342
44PPAR signaling pathway_Homo sapiens_hsa033201.03456997
45Chronic myeloid leukemia_Homo sapiens_hsa052201.02884968
46Butanoate metabolism_Homo sapiens_hsa006501.01313915
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00836022
48Caffeine metabolism_Homo sapiens_hsa002320.99481863
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99168614
50Lysine degradation_Homo sapiens_hsa003100.99065486
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96737429
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.96397376
53Spliceosome_Homo sapiens_hsa030400.95456013
54Carbon metabolism_Homo sapiens_hsa012000.94024210
55beta-Alanine metabolism_Homo sapiens_hsa004100.93335300
56RNA transport_Homo sapiens_hsa030130.93038914
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90432673
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88139906
59MicroRNAs in cancer_Homo sapiens_hsa052060.87575126
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.86775620
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86472598
62Pyruvate metabolism_Homo sapiens_hsa006200.86294728
63Renin-angiotensin system_Homo sapiens_hsa046140.86271188
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.85644430
65Arginine and proline metabolism_Homo sapiens_hsa003300.85633635
66Retinol metabolism_Homo sapiens_hsa008300.84910574
67Lysosome_Homo sapiens_hsa041420.83447196
68Pentose phosphate pathway_Homo sapiens_hsa000300.82547210
69Nucleotide excision repair_Homo sapiens_hsa034200.81556631
70ABC transporters_Homo sapiens_hsa020100.80346370
71Pancreatic cancer_Homo sapiens_hsa052120.77530116
72Proteasome_Homo sapiens_hsa030500.75431080
73Galactose metabolism_Homo sapiens_hsa000520.73215615
74mRNA surveillance pathway_Homo sapiens_hsa030150.70999734
75Sulfur relay system_Homo sapiens_hsa041220.69574464
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69507198
77* Vibrio cholerae infection_Homo sapiens_hsa051100.68213031
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67864764
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67136880
80Hippo signaling pathway_Homo sapiens_hsa043900.67111897
81Systemic lupus erythematosus_Homo sapiens_hsa053220.67045324
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66534747
83ECM-receptor interaction_Homo sapiens_hsa045120.65344764
84Fatty acid elongation_Homo sapiens_hsa000620.64771319
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64707132
86Steroid biosynthesis_Homo sapiens_hsa001000.64240743
87Pyrimidine metabolism_Homo sapiens_hsa002400.63372280
88Prion diseases_Homo sapiens_hsa050200.63365658
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63012842
90Legionellosis_Homo sapiens_hsa051340.62455075
91Glutathione metabolism_Homo sapiens_hsa004800.60276030
92Endometrial cancer_Homo sapiens_hsa052130.60001068
93Non-homologous end-joining_Homo sapiens_hsa034500.57978401
94Bladder cancer_Homo sapiens_hsa052190.57613465
95Protein digestion and absorption_Homo sapiens_hsa049740.56159760
96Tight junction_Homo sapiens_hsa045300.55976364
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55097599
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55088190
99Insulin resistance_Homo sapiens_hsa049310.54928614
100Non-small cell lung cancer_Homo sapiens_hsa052230.54578094
101Shigellosis_Homo sapiens_hsa051310.52472942
102Basal cell carcinoma_Homo sapiens_hsa052170.51981727
103Small cell lung cancer_Homo sapiens_hsa052220.49397196
104Bile secretion_Homo sapiens_hsa049760.49366343
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49085259
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48586104
107TGF-beta signaling pathway_Homo sapiens_hsa043500.47215145
108Vitamin digestion and absorption_Homo sapiens_hsa049770.47079182
109DNA replication_Homo sapiens_hsa030300.47067293
110AMPK signaling pathway_Homo sapiens_hsa041520.46458582
111Insulin signaling pathway_Homo sapiens_hsa049100.45330303
112Sphingolipid metabolism_Homo sapiens_hsa006000.44799753
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.44762910
114Notch signaling pathway_Homo sapiens_hsa043300.44158428
115Prostate cancer_Homo sapiens_hsa052150.42320699
116Fructose and mannose metabolism_Homo sapiens_hsa000510.39835401
117Viral carcinogenesis_Homo sapiens_hsa052030.39736561
118Focal adhesion_Homo sapiens_hsa045100.39639893
119* Thyroid hormone synthesis_Homo sapiens_hsa049180.37605631
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36492841
121Mismatch repair_Homo sapiens_hsa034300.34757958
122Metabolic pathways_Homo sapiens_hsa011000.31895157
123p53 signaling pathway_Homo sapiens_hsa041150.28855528
124Proteoglycans in cancer_Homo sapiens_hsa052050.28344233
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.27781128
126Amoebiasis_Homo sapiens_hsa051460.25236479
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24758935
128Glycerolipid metabolism_Homo sapiens_hsa005610.24321196
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.23874514
130Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23693853
131Adherens junction_Homo sapiens_hsa045200.22957068
132Base excision repair_Homo sapiens_hsa034100.20779844
133Thyroid cancer_Homo sapiens_hsa052160.19369006

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