PDIA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.27655562
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.27655562
3L-phenylalanine metabolic process (GO:0006558)6.24110502
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.24110502
5negative regulation of fibrinolysis (GO:0051918)5.74472369
6aromatic amino acid family catabolic process (GO:0009074)5.60852675
7regulation of fibrinolysis (GO:0051917)5.20922334
8glyoxylate metabolic process (GO:0046487)5.11951931
9sulfur amino acid catabolic process (GO:0000098)5.02357533
10kynurenine metabolic process (GO:0070189)5.02307112
11peptidyl-glutamic acid carboxylation (GO:0017187)5.01901729
12protein carboxylation (GO:0018214)5.01901729
13indole-containing compound catabolic process (GO:0042436)5.01635326
14indolalkylamine catabolic process (GO:0046218)5.01635326
15tryptophan catabolic process (GO:0006569)5.01635326
16regulation of protein activation cascade (GO:2000257)5.01328477
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.00415601
18cysteine metabolic process (GO:0006534)4.77262338
19bile acid biosynthetic process (GO:0006699)4.76887667
20tryptophan metabolic process (GO:0006568)4.76111854
21high-density lipoprotein particle remodeling (GO:0034375)4.75888849
22regulation of complement activation (GO:0030449)4.72700580
23urea cycle (GO:0000050)4.69022606
24urea metabolic process (GO:0019627)4.69022606
25serine family amino acid catabolic process (GO:0009071)4.67487636
26glycine metabolic process (GO:0006544)4.61537260
27complement activation, alternative pathway (GO:0006957)4.59636148
28alpha-linolenic acid metabolic process (GO:0036109)4.35722496
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.32845189
30nitrogen cycle metabolic process (GO:0071941)4.30159761
31homocysteine metabolic process (GO:0050667)4.28958514
32aromatic amino acid family metabolic process (GO:0009072)4.23644162
33reverse cholesterol transport (GO:0043691)4.20147888
34acylglycerol homeostasis (GO:0055090)4.19613958
35triglyceride homeostasis (GO:0070328)4.19613958
36serine family amino acid biosynthetic process (GO:0009070)4.14154628
37bile acid metabolic process (GO:0008206)4.08076119
38serine family amino acid metabolic process (GO:0009069)4.06906564
39amino-acid betaine metabolic process (GO:0006577)3.99253485
40tyrosine metabolic process (GO:0006570)3.97223883
41protein retention in ER lumen (GO:0006621)3.96476986
42protein-lipid complex remodeling (GO:0034368)3.96333803
43macromolecular complex remodeling (GO:0034367)3.96333803
44plasma lipoprotein particle remodeling (GO:0034369)3.96333803
45lysine catabolic process (GO:0006554)3.93001813
46lysine metabolic process (GO:0006553)3.93001813
47fibrinolysis (GO:0042730)3.92845409
48alpha-amino acid catabolic process (GO:1901606)3.85708166
49regulation of cholesterol esterification (GO:0010872)3.84010445
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.82210480
51regulation of triglyceride catabolic process (GO:0010896)3.78423675
52plasma lipoprotein particle clearance (GO:0034381)3.75597760
53very-low-density lipoprotein particle assembly (GO:0034379)3.74757724
54positive regulation of lipoprotein lipase activity (GO:0051006)3.73380971
55positive regulation of triglyceride lipase activity (GO:0061365)3.73380971
56bile acid and bile salt transport (GO:0015721)3.68124329
57cell adhesion mediated by integrin (GO:0033627)3.66937229
58imidazole-containing compound metabolic process (GO:0052803)3.63492538
59basement membrane organization (GO:0071711)3.60425975
60blood coagulation, intrinsic pathway (GO:0007597)3.60008372
61regulation of plasminogen activation (GO:0010755)3.57749551
62cellular amino acid catabolic process (GO:0009063)3.57302461
63cellular glucuronidation (GO:0052695)3.57025741
64negative regulation of cholesterol transport (GO:0032375)3.56795024
65negative regulation of sterol transport (GO:0032372)3.56795024
66phospholipid efflux (GO:0033700)3.52241363
67indolalkylamine metabolic process (GO:0006586)3.52173309
68skin morphogenesis (GO:0043589)3.50058225
69negative regulation of hemostasis (GO:1900047)3.49041311
70negative regulation of blood coagulation (GO:0030195)3.49041311
71proline biosynthetic process (GO:0006561)3.48651037
72regulation of cholesterol homeostasis (GO:2000188)3.48495044
73arginine metabolic process (GO:0006525)3.48180175
74coenzyme catabolic process (GO:0009109)3.47185856
75COPII vesicle coating (GO:0048208)3.46514398
76cellular modified amino acid catabolic process (GO:0042219)3.45087099
77cholesterol efflux (GO:0033344)3.40540954
78proline metabolic process (GO:0006560)3.40329596
79benzene-containing compound metabolic process (GO:0042537)3.39216763
80negative regulation of coagulation (GO:0050819)3.38745159
81lipoprotein metabolic process (GO:0042157)3.38423532
82L-serine metabolic process (GO:0006563)3.38116705
83cholesterol homeostasis (GO:0042632)3.37053579
84aldehyde catabolic process (GO:0046185)3.35338108
85cellular biogenic amine catabolic process (GO:0042402)3.34824327
86amine catabolic process (GO:0009310)3.34824327
87sterol homeostasis (GO:0055092)3.33508207
884-hydroxyproline metabolic process (GO:0019471)3.33385868
89heme transport (GO:0015886)3.31262057
90negative regulation of wound healing (GO:0061045)3.28733514
91plasma lipoprotein particle assembly (GO:0034377)3.26669386
92endodermal cell differentiation (GO:0035987)3.26036674
93regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.23012996
94folic acid metabolic process (GO:0046655)3.21664941
95protein activation cascade (GO:0072376)3.21355795
96complement activation, classical pathway (GO:0006958)3.18585447
97regulation of apoptotic cell clearance (GO:2000425)3.17462542
98regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.17066469
99positive regulation of hemostasis (GO:1900048)3.15809443
100positive regulation of blood coagulation (GO:0030194)3.15809443
101one-carbon metabolic process (GO:0006730)3.13230974
102complement activation (GO:0006956)3.12915499
103protein maturation by protein folding (GO:0022417)3.12729906
104acute-phase response (GO:0006953)3.11907671
105glucuronate metabolic process (GO:0019585)3.11803118
106uronic acid metabolic process (GO:0006063)3.11803118
107glutamate metabolic process (GO:0006536)3.11647088
108protein-lipid complex assembly (GO:0065005)3.09765983
109regulation of lipoprotein particle clearance (GO:0010984)3.09694993
110collagen fibril organization (GO:0030199)3.09043289
111ethanol oxidation (GO:0006069)3.08740450
112negative regulation of fatty acid biosynthetic process (GO:0045717)3.08299707
113negative regulation of protein activation cascade (GO:2000258)3.08182786
114cellular ketone body metabolic process (GO:0046950)3.07570189
115Golgi transport vesicle coating (GO:0048200)3.07272720
116COPI coating of Golgi vesicle (GO:0048205)3.07272720
117carboxylic acid catabolic process (GO:0046395)3.06122849
118organic acid catabolic process (GO:0016054)3.06122849
119positive regulation of fatty acid biosynthetic process (GO:0045723)3.05962536
120cytolysis (GO:0019835)3.05950537
121response to nitrosative stress (GO:0051409)3.05652560
122intestinal cholesterol absorption (GO:0030299)3.05525771
123nucleotide-sugar biosynthetic process (GO:0009226)3.04840465
124chondrocyte proliferation (GO:0035988)3.00999350
125negative regulation of lipase activity (GO:0060192)2.99686423
126hyaluronan catabolic process (GO:0030214)2.98844894
127positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.95239438
128negative regulation of complement activation (GO:0045916)2.93961819
129positive regulation of coagulation (GO:0050820)2.91450304
130plasma lipoprotein particle organization (GO:0071827)2.90480961
131peptidyl-proline hydroxylation (GO:0019511)2.82150326
132positive regulation of extracellular matrix organization (GO:1903055)2.81127451
133protein-lipid complex subunit organization (GO:0071825)2.77968512
134low-density lipoprotein particle remodeling (GO:0034374)2.76798750
135endothelial cell morphogenesis (GO:0001886)2.71686360
136epoxygenase P450 pathway (GO:0019373)2.69004826
137gap junction assembly (GO:0016264)2.66377020
138regulation of metalloenzyme activity (GO:0048552)2.63237641
139hyaluronan metabolic process (GO:0030212)2.63073810
140retina vasculature morphogenesis in camera-type eye (GO:0061299)2.61197740
141wound healing, spreading of epidermal cells (GO:0035313)2.58209300
142glutamine family amino acid biosynthetic process (GO:0009084)2.55313268
143negative regulation of fatty acid transport (GO:2000192)2.54222462
144drug catabolic process (GO:0042737)2.53949617
145protein hydroxylation (GO:0018126)2.52539827
146hemidesmosome assembly (GO:0031581)2.50361841
147positive regulation of osteoblast proliferation (GO:0033690)2.50075697
148platelet degranulation (GO:0002576)2.47882600
149omega-hydroxylase P450 pathway (GO:0097267)2.47482224
150protein N-linked glycosylation via asparagine (GO:0018279)2.46464508
151intestinal absorption (GO:0050892)2.45476581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.86876612
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.18091613
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.43522322
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.64661040
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.57519529
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.05929254
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.95314723
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.46075532
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.20461413
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.67675415
11CLOCK_20551151_ChIP-Seq_293T_Human2.28189334
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.07591256
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06946208
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.05859846
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04545569
16TP63_17297297_ChIP-ChIP_HaCaT_Human1.93418448
17* MYC_18555785_ChIP-Seq_MESCs_Mouse1.71560982
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.69290732
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67570757
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61015780
21STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58509699
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53827495
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53026598
24PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51011853
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50961754
26AR_21909140_ChIP-Seq_LNCAP_Human1.47247230
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46748736
28ZNF263_19887448_ChIP-Seq_K562_Human1.38691877
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36587880
30* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33332232
31* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32440807
32* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27698678
33NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.26552878
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26146476
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23991521
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22879566
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22217370
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.20441258
39BRD4_25478319_ChIP-Seq_HGPS_Human1.20210346
40UBF1/2_26484160_Chip-Seq_HMECs_Human1.18996797
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17761832
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16813656
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16742635
44GATA1_22025678_ChIP-Seq_K562_Human1.15894046
45E2F7_22180533_ChIP-Seq_HELA_Human1.13602952
46ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13599627
47TP53_22127205_ChIP-Seq_IMR90_Human1.13277004
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12894397
49* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12055730
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11193394
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10693567
52MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.10516268
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09547602
54TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08761341
55SOX2_20726797_ChIP-Seq_SW620_Human1.08687417
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07873247
57* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07772258
58CDX2_20551321_ChIP-Seq_CACO-2_Human1.06937381
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06858707
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06391013
61* HNF4A_19822575_ChIP-Seq_HepG2_Human1.06011959
62ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05903924
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05411155
64ATF3_27146783_Chip-Seq_COLON_Human1.05303151
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05079326
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05079326
67* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04683719
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.04140505
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03191239
70TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02636844
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02211644
72* CJUN_26792858_Chip-Seq_BT549_Human1.00968099
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00217865
74GABP_17652178_ChIP-ChIP_JURKAT_Human0.99791195
75DCP1A_22483619_ChIP-Seq_HELA_Human0.99040695
76GATA4_25053715_ChIP-Seq_YYC3_Human0.97954761
77ESR1_21235772_ChIP-Seq_MCF-7_Human0.97784603
78P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97634425
79* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96630650
80ELK3_25401928_ChIP-Seq_HUVEC_Human0.94990270
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94793464
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94788243
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94283800
84* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94003199
85ETS1_20019798_ChIP-Seq_JURKAT_Human0.93354305
86SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93219466
87MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92613734
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91382789
89RACK7_27058665_Chip-Seq_MCF-7_Human0.90818270
90NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90561987
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89908159
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89792177
93KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89378577
94* RARA_24833708_ChIP-Seq_LIVER_Mouse0.89326866
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88767452
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88558920
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.88460505
98* GABP_19822575_ChIP-Seq_HepG2_Human0.88364895
99FOXA2_19822575_ChIP-Seq_HepG2_Human0.88104926
100NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87806678
101OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87788646
102SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86346356
103EP300_21415370_ChIP-Seq_HL-1_Mouse0.86064459
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85712719
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85592799
106HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85452981
107* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85222950
108* RARB_24833708_ChIP-Seq_LIVER_Mouse0.81892906
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80607216
110EST1_17652178_ChIP-ChIP_JURKAT_Human0.80032922
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79616961
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78563715
113XRN2_22483619_ChIP-Seq_HELA_Human0.78491998
114MYCN_18555785_ChIP-Seq_MESCs_Mouse0.78387524
115SOX17_20123909_ChIP-Seq_XEN_Mouse0.76889336
116LXR_22292898_ChIP-Seq_THP-1_Human0.76760146
117POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.76517563
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76018061
119ESR2_21235772_ChIP-Seq_MCF-7_Human0.74187162
120KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.73777969
121KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.73777969
122KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.73777969
123* GATA6_25053715_ChIP-Seq_YYC3_Human0.72900205
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.70694016
125ELF1_17652178_ChIP-ChIP_JURKAT_Human0.68111398
126* SRF_21415370_ChIP-Seq_HL-1_Mouse0.68049783
127EGR1_19374776_ChIP-ChIP_THP-1_Human0.67742029
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.67721298
129KDM5A_27292631_Chip-Seq_BREAST_Human0.67237635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.45830381
2MP0005360_urolithiasis5.93648871
3MP0005085_abnormal_gallbladder_physiolo5.20892831
4MP0005365_abnormal_bile_salt4.99661034
5MP0003806_abnormal_nucleotide_metabolis4.11211299
6MP0008875_abnormal_xenobiotic_pharmacok3.57482634
7MP0009840_abnormal_foam_cell3.26041485
8MP0003252_abnormal_bile_duct3.22435095
9MP0010329_abnormal_lipoprotein_level2.81722671
10MP0005257_abnormal_intraocular_pressure2.76690232
11MP0003705_abnormal_hypodermis_morpholog2.67611061
12MP0010368_abnormal_lymphatic_system2.49948126
13MP0005083_abnormal_biliary_tract2.46426506
14MP0003195_calcinosis2.45065210
15MP0005332_abnormal_amino_acid2.28462740
16MP0001666_abnormal_nutrient_absorption2.12239211
17MP0008438_abnormal_cutaneous_collagen2.06586471
18MP0003950_abnormal_plasma_membrane1.91613156
19MP0003941_abnormal_skin_development1.89585018
20MP0003191_abnormal_cellular_cholesterol1.87589647
21MP0000609_abnormal_liver_physiology1.85571814
22MP0004019_abnormal_vitamin_homeostasis1.81121370
23MP0002138_abnormal_hepatobiliary_system1.71465935
24MP0005319_abnormal_enzyme/_coenzyme1.66667613
25MP0003868_abnormal_feces_composition1.61272213
26MP0001958_emphysema1.60083342
27MP0002118_abnormal_lipid_homeostasis1.56124368
28MP0004272_abnormal_basement_membrane1.54812720
29MP0009697_abnormal_copulation1.50865062
30MP0001764_abnormal_homeostasis1.44898900
31MP0003186_abnormal_redox_activity1.41390891
32MP0004858_abnormal_nervous_system1.38672222
33MP0005623_abnormal_meninges_morphology1.36054558
34MP0006054_spinal_hemorrhage1.34939136
35MP0000598_abnormal_liver_morphology1.31930869
36MP0002089_abnormal_postnatal_growth/wei1.31058033
37MP0009643_abnormal_urine_homeostasis1.29125858
38MP0005220_abnormal_exocrine_pancreas1.27207109
39MP0005058_abnormal_lysosome_morphology1.19364525
40MP0005023_abnormal_wound_healing1.15365670
41MP0009053_abnormal_anal_canal1.12285002
42MP0004264_abnormal_extraembryonic_tissu1.11376084
43MP0004233_abnormal_muscle_weight1.11251505
44MP0003566_abnormal_cell_adhesion1.10111144
45MP0005503_abnormal_tendon_morphology1.09831054
46MP0009384_cardiac_valve_regurgitation1.08892375
47MP0005084_abnormal_gallbladder_morpholo1.08012435
48MP0004782_abnormal_surfactant_physiolog1.05970191
49MP0002876_abnormal_thyroid_physiology1.05564659
50MP0002877_abnormal_melanocyte_morpholog1.05121294
51MP0000762_abnormal_tongue_morphology1.03683426
52MP0003279_aneurysm1.01346909
53MP0003718_maternal_effect1.01090704
54MP0009780_abnormal_chondrocyte_physiolo1.00433367
55MP0005451_abnormal_body_composition0.99223638
56MP0005408_hypopigmentation0.99123016
57MP0000003_abnormal_adipose_tissue0.98102621
58MP0003011_delayed_dark_adaptation0.97773767
59MP0009250_abnormal_appendicular_skeleto0.97230482
60MP0001849_ear_inflammation0.95333944
61MP0003385_abnormal_body_wall0.94226337
62MP0001756_abnormal_urination0.92370484
63MP0010352_gastrointestinal_tract_polyps0.92259661
64MP0005584_abnormal_enzyme/coenzyme_acti0.91362829
65MP0005275_abnormal_skin_tensile0.90984762
66MP0005076_abnormal_cell_differentiation0.90397197
67MP0000467_abnormal_esophagus_morphology0.89539524
68MP0005670_abnormal_white_adipose0.89539523
69MP0005395_other_phenotype0.89094487
70MP0003942_abnormal_urinary_system0.88744711
71MP0001661_extended_life_span0.86904711
72MP0003693_abnormal_embryo_hatching0.86869153
73MP0001915_intracranial_hemorrhage0.84760656
74MP0005197_abnormal_uvea_morphology0.84498360
75MP0005376_homeostasis/metabolism_phenot0.83340435
76MP0002108_abnormal_muscle_morphology0.83339341
77MP0001542_abnormal_bone_strength0.83319790
78MP0002295_abnormal_pulmonary_circulatio0.82271101
79MP0003091_abnormal_cell_migration0.81029475
80MP0002282_abnormal_trachea_morphology0.79214411
81MP0001614_abnormal_blood_vessel0.78643338
82MP0002060_abnormal_skin_morphology0.76231844
83MP0009763_increased_sensitivity_to0.76212874
84MP0001881_abnormal_mammary_gland0.75892938
85MP0004957_abnormal_blastocyst_morpholog0.74442729
86MP0001243_abnormal_dermal_layer0.74042563
87MP0008932_abnormal_embryonic_tissue0.73518451
88MP0002932_abnormal_joint_morphology0.73486318
89MP0005409_darkened_coat_color0.72678247
90MP0005647_abnormal_sex_gland0.72381861
91MP0003656_abnormal_erythrocyte_physiolo0.72348845
92MP0002697_abnormal_eye_size0.70273396
93MP0002938_white_spotting0.69820849
94MP0009642_abnormal_blood_homeostasis0.69540697
95MP0001879_abnormal_lymphatic_vessel0.68750521
96MP0003315_abnormal_perineum_morphology0.68082699
97MP0005636_abnormal_mineral_homeostasis0.67448925
98MP0010030_abnormal_orbit_morphology0.67118563
99MP0005266_abnormal_metabolism0.66844572
100MP0000639_abnormal_adrenal_gland0.66205490
101MP0001299_abnormal_eye_distance/0.64627451
102MP0000163_abnormal_cartilage_morphology0.63909106
103MP0003115_abnormal_respiratory_system0.63743941
104MP0000534_abnormal_ureter_morphology0.63202564
105MP0008469_abnormal_protein_level0.62497558
106MP0002078_abnormal_glucose_homeostasis0.61340190
107MP0003122_maternal_imprinting0.60983623
108MP0002168_other_aberrant_phenotype0.60334488
109MP0002086_abnormal_extraembryonic_tissu0.60111209
110MP0009672_abnormal_birth_weight0.59966778
111MP0002925_abnormal_cardiovascular_devel0.59156730
112MP0000428_abnormal_craniofacial_morphol0.59063745
113MP0000013_abnormal_adipose_tissue0.57688897
114MP0006036_abnormal_mitochondrial_physio0.57134183
115MP0002928_abnormal_bile_duct0.56886260
116MP0001944_abnormal_pancreas_morphology0.56491383
117MP0000249_abnormal_blood_vessel0.54599802
118MP0000767_abnormal_smooth_muscle0.54514825
119MP0004883_abnormal_blood_vessel0.54349050
120MP0002896_abnormal_bone_mineralization0.54104462
121MP0002088_abnormal_embryonic_growth/wei0.52663096
122MP0009764_decreased_sensitivity_to0.52625713
123MP0003984_embryonic_growth_retardation0.52271203
124MP0005164_abnormal_response_to0.50826590
125MP0002269_muscular_atrophy0.50136261
126MP0005595_abnormal_vascular_smooth0.49389653
127MP0002128_abnormal_blood_circulation0.49081240
128MP0001672_abnormal_embryogenesis/_devel0.49065998
129MP0005380_embryogenesis_phenotype0.49065998
130MP0003567_abnormal_fetal_cardiomyocyte0.48886611
131MP0005187_abnormal_penis_morphology0.47440792
132MP0004197_abnormal_fetal_growth/weight/0.47104235
133MP0005508_abnormal_skeleton_morphology0.46650360
134MP0002136_abnormal_kidney_physiology0.45794312
135MP0001730_embryonic_growth_arrest0.45619433
136MP0005248_abnormal_Harderian_gland0.45530955
137MP0005334_abnormal_fat_pad0.44402511
138MP0002135_abnormal_kidney_morphology0.44050833
139MP0002971_abnormal_brown_adipose0.43761097

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.56441478
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.40380193
3Intrahepatic cholestasis (HP:0001406)6.21485374
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.98486316
5Prolonged partial thromboplastin time (HP:0003645)5.41857727
6Xanthomatosis (HP:0000991)5.41854068
7Hypobetalipoproteinemia (HP:0003563)5.38962737
8Abnormality of the intrinsic pathway (HP:0010989)4.48232803
9Hypoglycemic coma (HP:0001325)4.40511824
10Complement deficiency (HP:0004431)4.35034472
11Hypolipoproteinemia (HP:0010981)4.31569931
12Abnormality of the common coagulation pathway (HP:0010990)4.30256924
13Hyperlipoproteinemia (HP:0010980)4.24440472
14Hypoalphalipoproteinemia (HP:0003233)3.93723790
15Hyperammonemia (HP:0001987)3.81363202
16Joint hemorrhage (HP:0005261)3.78812776
17Abnormality of dentin (HP:0010299)3.76519807
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.73282308
19Hyperglycinemia (HP:0002154)3.73277574
20Aortic dissection (HP:0002647)3.70410304
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.69598040
22Soft skin (HP:0000977)3.64509601
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.57018054
24Abnormality of pyrimidine metabolism (HP:0004353)3.56768805
25Vascular tortuosity (HP:0004948)3.56425997
26Protrusio acetabuli (HP:0003179)3.53781709
27Fat malabsorption (HP:0002630)3.47071862
28Abnormality of methionine metabolism (HP:0010901)3.46587820
29Abnormality of complement system (HP:0005339)3.41781842
30Ketosis (HP:0001946)3.38968802
31Arterial tortuosity (HP:0005116)3.32348845
32Hyperglycinuria (HP:0003108)3.27784419
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.25040486
34Abnormality of carpal bone ossification (HP:0006257)3.21543045
35Epidermoid cyst (HP:0200040)3.15117598
36Abnormality of glycine metabolism (HP:0010895)3.14622025
37Abnormality of serine family amino acid metabolism (HP:0010894)3.14622025
38Bladder diverticulum (HP:0000015)3.12865540
39Premature rupture of membranes (HP:0001788)3.09529790
40Atrophic scars (HP:0001075)3.07294244
41Abnormality of the acetabulum (HP:0003170)2.99255643
42Blue sclerae (HP:0000592)2.97270169
43Cervical subluxation (HP:0003308)2.93043810
44Fragile skin (HP:0001030)2.89324832
45Hypoglycemic seizures (HP:0002173)2.89198612
46Abnormality of fatty-acid metabolism (HP:0004359)2.87968718
47Myocardial infarction (HP:0001658)2.80273104
48Vertebral compression fractures (HP:0002953)2.80235288
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.79317735
50Wormian bones (HP:0002645)2.77065345
51Hepatocellular carcinoma (HP:0001402)2.73786029
52Neonatal short-limb short stature (HP:0008921)2.70585050
53Abnormality of nucleobase metabolism (HP:0010932)2.69958289
54Hyperglycemia (HP:0003074)2.67428223
55Ankle contracture (HP:0006466)2.67271326
56Abnormality of serum amino acid levels (HP:0003112)2.66690633
57Hyperinsulinemic hypoglycemia (HP:0000825)2.65290475
58Abnormal ossification of hand bones (HP:0005921)2.61463406
59Hypercholesterolemia (HP:0003124)2.61318839
60Steatorrhea (HP:0002570)2.60008411
61Hyperbilirubinemia (HP:0002904)2.59660294
62Abnormal cartilage morphology (HP:0002763)2.56261484
63Aortic aneurysm (HP:0004942)2.55897687
64Conjugated hyperbilirubinemia (HP:0002908)2.54971809
65Ketoacidosis (HP:0001993)2.53521349
66Spontaneous abortion (HP:0005268)2.52991436
67Abnormality of the Achilles tendon (HP:0005109)2.52816997
68Skin nodule (HP:0200036)2.50490038
69Follicular hyperkeratosis (HP:0007502)2.50360874
70Nonimmune hydrops fetalis (HP:0001790)2.47940331
71Abnormal hand bone ossification (HP:0010660)2.45358666
72Flat acetabular roof (HP:0003180)2.43441383
73Peritonitis (HP:0002586)2.41438366
74Esophageal varix (HP:0002040)2.39622530
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36331074
76Dicarboxylic aciduria (HP:0003215)2.36331074
77Gout (HP:0001997)2.34728555
78Delayed CNS myelination (HP:0002188)2.33528383
79Spastic diplegia (HP:0001264)2.31697762
80Abnormality of purine metabolism (HP:0004352)2.26553031
81Generalized aminoaciduria (HP:0002909)2.25362455
82Hypochromic microcytic anemia (HP:0004840)2.23893465
83Small epiphyses (HP:0010585)2.22637151
84Shallow orbits (HP:0000586)2.22489669
85Spinal rigidity (HP:0003306)2.22348100
86Irritability (HP:0000737)2.21904337
87Polycythemia (HP:0001901)2.20519824
88Abnormal delivery (HP:0001787)2.16137380
89Hyperextensible skin (HP:0000974)2.15748095
90Malnutrition (HP:0004395)2.13522689
91Renal duplication (HP:0000075)2.13131043
92Lethargy (HP:0001254)2.12162444
93Late onset (HP:0003584)2.12052473
94Achilles tendon contracture (HP:0001771)2.12003851
95Cardiovascular calcification (HP:0011915)2.11938625
96Short nail (HP:0001799)2.10851591
97Coxa vara (HP:0002812)2.10811624
98Elbow flexion contracture (HP:0002987)2.09703559
99Ovoid vertebral bodies (HP:0003300)2.07570770
100Vascular calcification (HP:0004934)2.06812118
101Broad metatarsal (HP:0001783)2.06702532
102Mitral stenosis (HP:0001718)2.02682734
103Systemic lupus erythematosus (HP:0002725)2.02351262
104Genu recurvatum (HP:0002816)2.01589152
105Joint laxity (HP:0001388)2.00524798
106Cerebral aneurysm (HP:0004944)1.99905820
107Hydroxyprolinuria (HP:0003080)1.99471633
108Abnormality of proline metabolism (HP:0010907)1.99471633
109Back pain (HP:0003418)1.99315180
110Menorrhagia (HP:0000132)1.97835090
111Metabolic acidosis (HP:0001942)1.96492418
112Ulnar bowing (HP:0003031)1.95132959
113Abnormal enzyme/coenzyme activity (HP:0012379)1.94348472
114Thrombophlebitis (HP:0004418)1.93304334
115Biconcave vertebral bodies (HP:0004586)1.91878196
116Premature skin wrinkling (HP:0100678)1.89649162
117Symptomatic seizures (HP:0011145)1.89469000
118Thin skin (HP:0000963)1.88656260
119Opisthotonus (HP:0002179)1.88090318
120Mitral valve prolapse (HP:0001634)1.87303887
121Breech presentation (HP:0001623)1.86146118
122Abnormality of endocrine pancreas physiology (HP:0012093)1.84794020
123Abnormality of the pancreatic islet cells (HP:0006476)1.84794020
124Coronal craniosynostosis (HP:0004440)1.83729745
125Neonatal onset (HP:0003623)1.82533093
126Pancreatitis (HP:0001733)1.81343379
127Bowel diverticulosis (HP:0005222)1.80796467
128Cupped ribs (HP:0000887)1.80579344
129Inguinal hernia (HP:0000023)1.80330099
130Abnormal tarsal ossification (HP:0008369)1.79701138
131Abnormality of alkaline phosphatase activity (HP:0004379)1.78543073
132Enlarged kidneys (HP:0000105)1.77794480
133Disproportionate tall stature (HP:0001519)1.77672695
134Proximal tubulopathy (HP:0000114)1.76257992
135Hemorrhage of the eye (HP:0011885)1.76032846
136Abnormal gallbladder morphology (HP:0012437)1.75903495
137Abnormality of transition element cation homeostasis (HP:0011030)1.75664049
138Aortic regurgitation (HP:0001659)1.74577783
139Osteoarthritis (HP:0002758)1.74411788
140Protuberant abdomen (HP:0001538)1.73470423
141Redundant skin (HP:0001582)1.73383076
142Insulin resistance (HP:0000855)1.72519584
143Glomerulonephritis (HP:0000099)1.71860246
144Increased serum pyruvate (HP:0003542)1.71125767
145Dilatation of the ascending aorta (HP:0005111)1.70845439
146Platyspondyly (HP:0000926)1.70713590
147Brushfield spots (HP:0001088)1.70688774
148Ectopia lentis (HP:0001083)1.69407389
149Conjunctival telangiectasia (HP:0000524)1.68555501
150Abnormality of glycolysis (HP:0004366)1.68000066
151Beaking of vertebral bodies (HP:0004568)1.67783687
152Abnormal gallbladder physiology (HP:0012438)1.66360440
153Cholecystitis (HP:0001082)1.66360440
154Spinal cord compression (HP:0002176)1.65617692
155Elevated alkaline phosphatase (HP:0003155)1.65279024
156Wide anterior fontanel (HP:0000260)1.65051098
157Aneurysm (HP:0002617)1.64771157
158Venous insufficiency (HP:0005293)1.61587739
159Generalized amyotrophy (HP:0003700)1.61447776
160Nephritis (HP:0000123)1.61423011
161Hypophosphatemic rickets (HP:0004912)1.61060515
162Spondylolisthesis (HP:0003302)1.60510742
163Urinary glycosaminoglycan excretion (HP:0003541)1.60079265
164Mucopolysacchariduria (HP:0008155)1.60079265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.49745381
2BCKDK3.99289006
3TIE13.05735801
4EPHA22.80191371
5KDR2.74788415
6TRIB32.63611299
7FGFR42.38826081
8LATS12.19795467
9SIK12.15604505
10NTRK12.13450287
11PKN22.11480018
12ICK2.10739797
13EEF2K2.09361200
14LATS22.00315248
15FLT31.99879512
16MYLK1.92848763
17TAOK31.90996584
18STK38L1.89298081
19WNK41.81241553
20MAP3K31.79979757
21PTK61.69819827
22ERBB41.57930858
23WEE11.56869061
24MAP3K111.56157192
25CDK81.49547202
26INSRR1.49259190
27PBK1.48008651
28AKT31.47875938
29PDGFRA1.40233455
30MAP2K31.37547302
31BUB11.32341795
32TGFBR11.32151669
33NME21.31075194
34ARAF1.31061286
35CDK121.30672047
36PTK21.30392748
37PIK3CG1.29531829
38BRSK21.26600201
39RIPK11.21242323
40DDR21.18606111
41MET1.17773018
42MAPK151.17574917
43ABL21.16577888
44NEK91.15381793
45PASK1.15063387
46LIMK11.13366726
47TESK21.08996936
48LMTK21.08937736
49EIF2AK31.07171853
50PIM21.06159358
51MAPK111.04445688
52PAK41.04295141
53STK31.02882384
54TGFBR21.01892354
55EIF2AK11.01816325
56MAP3K80.97418385
57TAOK20.96904312
58RPS6KA40.96618200
59ILK0.95760855
60NEK10.93090777
61TTK0.90121118
62CDK60.89987995
63MAP3K100.86635822
64CDK40.85268282
65FER0.82618327
66MTOR0.82217368
67NEK20.81580418
68PDGFRB0.81479209
69ACVR1B0.80454782
70SMG10.80373862
71MAP2K20.79982106
72PNCK0.78150920
73PAK20.78062061
74STK390.76526713
75TESK10.75708333
76DYRK1B0.75321445
77CAMK1G0.74689874
78MST1R0.71645447
79CDK70.67736476
80MAPKAPK50.67721512
81RPS6KB20.66865861
82CAMK1D0.63803530
83PLK40.63092269
84PLK30.60127930
85PLK10.58796613
86MAPKAPK30.58685772
87ERBB20.57150397
88FRK0.57061592
89FGFR30.57011400
90EPHB20.56164302
91TRPM70.56154315
92PDK20.56149838
93LRRK20.54766389
94PRKG20.54750753
95MAP2K10.54613751
96MOS0.54485034
97GSK3A0.54395986
98TSSK60.53775346
99NME10.52577385
100DYRK30.52006032
101SCYL20.51913660
102CHEK20.51313752
103RAF10.50174231
104BRAF0.49736715
105TYK20.49341253
106TAOK10.48238832
107BMX0.47495438
108VRK20.47371922
109MAP3K50.47210863
110TBK10.46498809
111STK100.45267795
112AURKB0.45136900
113AURKA0.45005563
114CSNK2A20.44557587
115WNK10.44477424
116PIK3CA0.43149232
117AKT20.42546967
118CDC42BPA0.40691967
119EPHA30.40635071
120BRSK10.40070036
121RPS6KA20.38712244
122STK160.38573785
123CLK10.37551224
124PINK10.37485723
125IRAK30.36550415
126PAK10.36046139
127ROCK20.34306854
128PIM10.29200721
129PAK30.28729135
130CSNK2A10.28605458
131FGFR10.28233081
132CSK0.27859042
133MAP3K60.27464780
134ZAK0.27439338

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.06799759
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18041112
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.98269235
4Nitrogen metabolism_Homo sapiens_hsa009102.92569694
5Complement and coagulation cascades_Homo sapiens_hsa046102.83455625
6Arginine biosynthesis_Homo sapiens_hsa002202.82438096
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.70171829
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55687108
9Tryptophan metabolism_Homo sapiens_hsa003802.54331385
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20526867
11Fatty acid degradation_Homo sapiens_hsa000712.18766889
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12784590
13Selenocompound metabolism_Homo sapiens_hsa004502.12252453
14Drug metabolism - other enzymes_Homo sapiens_hsa009832.09874870
15Folate biosynthesis_Homo sapiens_hsa007901.95489236
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.94582353
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.91203596
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83993128
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.76295129
20Peroxisome_Homo sapiens_hsa041461.74194460
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72546552
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72184112
23Histidine metabolism_Homo sapiens_hsa003401.70351744
24Chemical carcinogenesis_Homo sapiens_hsa052041.69788018
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.64490584
26Butanoate metabolism_Homo sapiens_hsa006501.61155189
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.57639991
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54049439
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.53060090
30One carbon pool by folate_Homo sapiens_hsa006701.52206357
31PPAR signaling pathway_Homo sapiens_hsa033201.51495089
32Sulfur metabolism_Homo sapiens_hsa009201.50378988
33Retinol metabolism_Homo sapiens_hsa008301.47395119
34Other glycan degradation_Homo sapiens_hsa005111.46257979
35Caffeine metabolism_Homo sapiens_hsa002321.45677612
36Fatty acid metabolism_Homo sapiens_hsa012121.45657390
37Biosynthesis of amino acids_Homo sapiens_hsa012301.44396887
38Phenylalanine metabolism_Homo sapiens_hsa003601.42989891
39Propanoate metabolism_Homo sapiens_hsa006401.42556096
40beta-Alanine metabolism_Homo sapiens_hsa004101.41917746
41Staphylococcus aureus infection_Homo sapiens_hsa051501.38684918
42Tyrosine metabolism_Homo sapiens_hsa003501.28957164
43Starch and sucrose metabolism_Homo sapiens_hsa005001.27533100
44Fat digestion and absorption_Homo sapiens_hsa049751.25133325
45Sulfur relay system_Homo sapiens_hsa041221.23639113
46Bile secretion_Homo sapiens_hsa049761.21810144
47Carbon metabolism_Homo sapiens_hsa012001.21625024
48Arginine and proline metabolism_Homo sapiens_hsa003301.20279729
49Pyruvate metabolism_Homo sapiens_hsa006201.13702184
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13117071
51Vitamin B6 metabolism_Homo sapiens_hsa007501.12436916
52Vitamin digestion and absorption_Homo sapiens_hsa049771.06494632
53Glutathione metabolism_Homo sapiens_hsa004800.96716981
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.94537033
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94460055
56Pentose phosphate pathway_Homo sapiens_hsa000300.90113995
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89658745
58Steroid biosynthesis_Homo sapiens_hsa001000.89585235
59Focal adhesion_Homo sapiens_hsa045100.88585645
60ABC transporters_Homo sapiens_hsa020100.87965925
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85291938
62Lysine degradation_Homo sapiens_hsa003100.83297416
63Fatty acid elongation_Homo sapiens_hsa000620.82738342
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80682798
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75793149
66Galactose metabolism_Homo sapiens_hsa000520.75503763
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75111622
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75091865
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70800827
70Fatty acid biosynthesis_Homo sapiens_hsa000610.68553259
71Thyroid hormone synthesis_Homo sapiens_hsa049180.64476382
72Fructose and mannose metabolism_Homo sapiens_hsa000510.62251190
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.58047563
74Proteasome_Homo sapiens_hsa030500.56886348
75TGF-beta signaling pathway_Homo sapiens_hsa043500.55155002
76Protein export_Homo sapiens_hsa030600.52404900
77Metabolic pathways_Homo sapiens_hsa011000.52008637
78Prion diseases_Homo sapiens_hsa050200.51866052
79Sphingolipid metabolism_Homo sapiens_hsa006000.50439072
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48607067
81Proteoglycans in cancer_Homo sapiens_hsa052050.48256467
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46532336
83Glycerolipid metabolism_Homo sapiens_hsa005610.46178908
84Nucleotide excision repair_Homo sapiens_hsa034200.45049757
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43923934
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43377186
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42320619
88Pyrimidine metabolism_Homo sapiens_hsa002400.41852704
89Adherens junction_Homo sapiens_hsa045200.35476396
90N-Glycan biosynthesis_Homo sapiens_hsa005100.31085710
91Linoleic acid metabolism_Homo sapiens_hsa005910.30308869
92Insulin resistance_Homo sapiens_hsa049310.28267609
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28195060
94Thyroid cancer_Homo sapiens_hsa052160.26379323
95ECM-receptor interaction_Homo sapiens_hsa045120.25478795
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24605372
97Bladder cancer_Homo sapiens_hsa052190.23188750
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.21236068
99DNA replication_Homo sapiens_hsa030300.19874912
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.19253896
101Protein digestion and absorption_Homo sapiens_hsa049740.16935632
102Regulation of autophagy_Homo sapiens_hsa041400.15754984
103Renin-angiotensin system_Homo sapiens_hsa046140.15297529
104RNA transport_Homo sapiens_hsa030130.13408762
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.12214517
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11354118
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.09564422
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.08544313
109p53 signaling pathway_Homo sapiens_hsa041150.08257941
110AMPK signaling pathway_Homo sapiens_hsa041520.08243882
111Glucagon signaling pathway_Homo sapiens_hsa049220.07522110
112Amoebiasis_Homo sapiens_hsa051460.07266258
113Arachidonic acid metabolism_Homo sapiens_hsa005900.04846585
114Base excision repair_Homo sapiens_hsa034100.02731188
115Small cell lung cancer_Homo sapiens_hsa052220.00112874

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