PDIA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)8.36430795
2protein retention in ER lumen (GO:0006621)6.82679532
3signal peptide processing (GO:0006465)5.88238506
4COPII vesicle coating (GO:0048208)5.72243603
5* activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.52074368
6* positive regulation of nuclease activity (GO:0032075)5.42292267
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.15155594
8sequestering of metal ion (GO:0051238)5.08748676
9* regulation of nuclease activity (GO:0032069)4.98314914
10* endoplasmic reticulum unfolded protein response (GO:0030968)4.89629893
11ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.76955325
12* cellular response to unfolded protein (GO:0034620)4.73842080
13protein maturation by protein folding (GO:0022417)4.72024653
14* cellular response to topologically incorrect protein (GO:0035967)4.54190835
15* ER-nucleus signaling pathway (GO:0006984)4.48464452
16protein N-linked glycosylation via asparagine (GO:0018279)4.36013977
17establishment of integrated proviral latency (GO:0075713)4.33673921
18peptidyl-asparagine modification (GO:0018196)4.32612979
194-hydroxyproline metabolic process (GO:0019471)4.15880235
20nuclear pore complex assembly (GO:0051292)4.12265741
21* response to endoplasmic reticulum stress (GO:0034976)4.07480131
22ER overload response (GO:0006983)4.06339741
23vesicle coating (GO:0006901)4.04959363
24folic acid-containing compound biosynthetic process (GO:0009396)3.99814757
25protein N-linked glycosylation (GO:0006487)3.97140747
26exocrine pancreas development (GO:0031017)3.92031089
27UDP-N-acetylglucosamine metabolic process (GO:0006047)3.88709003
28* response to unfolded protein (GO:0006986)3.76541761
29* response to topologically incorrect protein (GO:0035966)3.64676484
30peptide catabolic process (GO:0043171)3.60878168
31nuclear pore organization (GO:0006999)3.58198036
32DNA strand elongation involved in DNA replication (GO:0006271)3.54346705
33ribosome assembly (GO:0042255)3.52082907
34DNA strand elongation (GO:0022616)3.43518029
35establishment of viral latency (GO:0019043)3.42140827
36proline biosynthetic process (GO:0006561)3.35252294
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26243255
38nucleobase-containing small molecule interconversion (GO:0015949)3.23068816
39chaperone-mediated protein folding (GO:0061077)3.19850241
40mitotic chromosome condensation (GO:0007076)3.19469661
41protein targeting to ER (GO:0045047)3.19333308
42cotranslational protein targeting to membrane (GO:0006613)3.17607621
43mitotic metaphase plate congression (GO:0007080)3.14077857
44response to testosterone (GO:0033574)3.12603655
45ER to Golgi vesicle-mediated transport (GO:0006888)3.10585769
46nucleotide-sugar biosynthetic process (GO:0009226)3.09389602
47protein localization to kinetochore (GO:0034501)3.08833376
48valine metabolic process (GO:0006573)3.06751295
49peptidyl-proline hydroxylation (GO:0019511)3.04541896
50establishment of protein localization to endoplasmic reticulum (GO:0072599)3.03654444
51telomere maintenance via semi-conservative replication (GO:0032201)3.03270379
52mitotic sister chromatid segregation (GO:0000070)3.02305910
53protein autoprocessing (GO:0016540)3.02173546
54protein localization to chromosome, centromeric region (GO:0071459)3.01238372
55protein localization to endoplasmic reticulum (GO:0070972)3.00128234
56pore complex assembly (GO:0046931)2.96141700
57very-low-density lipoprotein particle assembly (GO:0034379)2.94823216
58cell adhesion mediated by integrin (GO:0033627)2.91415697
59* cell redox homeostasis (GO:0045454)2.91410240
60tetrahydrofolate metabolic process (GO:0046653)2.90805539
61nucleotide-sugar metabolic process (GO:0009225)2.87522031
62GDP-mannose metabolic process (GO:0019673)2.86406665
63peptide hormone processing (GO:0016486)2.85842173
64protein complex localization (GO:0031503)2.85306955
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84245635
66glandular epithelial cell differentiation (GO:0002067)2.82611342
67pteridine-containing compound biosynthetic process (GO:0042559)2.81343023
68negative regulation of fibrinolysis (GO:0051918)2.81260292
69branching involved in prostate gland morphogenesis (GO:0060442)2.80568181
70sister chromatid segregation (GO:0000819)2.78851550
71tRNA aminoacylation for protein translation (GO:0006418)2.78491777
72mitotic nuclear envelope disassembly (GO:0007077)2.78046775
73endocrine pancreas development (GO:0031018)2.77738448
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.76683641
75maintenance of protein localization in organelle (GO:0072595)2.75871522
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.75301453
77pinocytosis (GO:0006907)2.74133459
78galactose catabolic process (GO:0019388)2.73298987
79IMP metabolic process (GO:0046040)2.70243233
80negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69295446
81negative regulation of ligase activity (GO:0051352)2.69295446
82proteasome assembly (GO:0043248)2.68452199
83cellular protein complex localization (GO:0034629)2.66481057
84regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.65841550
85heterochromatin organization (GO:0070828)2.65182914
86amino acid activation (GO:0043038)2.64975825
87tRNA aminoacylation (GO:0043039)2.64975825
88regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.63301448
89DNA replication initiation (GO:0006270)2.63085467
90metaphase plate congression (GO:0051310)2.62091844
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60931678
92maternal placenta development (GO:0001893)2.60383765
93protein hydroxylation (GO:0018126)2.60356522
94purine nucleobase biosynthetic process (GO:0009113)2.58320858
95sulfur amino acid catabolic process (GO:0000098)2.57933674
96nucleobase biosynthetic process (GO:0046112)2.57827320
97regulation of mitotic spindle organization (GO:0060236)2.57610424
98nuclear envelope disassembly (GO:0051081)2.56933875
99membrane disassembly (GO:0030397)2.56933875
100telomere maintenance via recombination (GO:0000722)2.53393927
101double-strand break repair via nonhomologous end joining (GO:0006303)2.52571040
102non-recombinational repair (GO:0000726)2.52571040
103DNA ligation (GO:0006266)2.52061317
104hormone catabolic process (GO:0042447)2.51684964
105paraxial mesoderm development (GO:0048339)2.49465779
106regulation of sister chromatid cohesion (GO:0007063)2.49233740
107formation of translation preinitiation complex (GO:0001731)2.48373339
108Golgi organization (GO:0007030)2.46621570
109skin morphogenesis (GO:0043589)2.46177847
110proline metabolic process (GO:0006560)2.45737809
111keratan sulfate catabolic process (GO:0042340)2.45626316
112establishment of chromosome localization (GO:0051303)2.45386330
113ribosomal small subunit assembly (GO:0000028)2.44552037
114mitotic recombination (GO:0006312)2.43826091
115regulation of spindle organization (GO:0090224)2.42387466
116regulation of cellular amino acid metabolic process (GO:0006521)2.42348679
117plasma lipoprotein particle assembly (GO:0034377)2.42281115
118regulation of fibrinolysis (GO:0051917)2.41490770
119IMP biosynthetic process (GO:0006188)2.41225228
120peptidyl-glutamic acid carboxylation (GO:0017187)2.41189893
121protein carboxylation (GO:0018214)2.41189893
122regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.40273114
123regulation of translational termination (GO:0006449)2.40261420
124type B pancreatic cell development (GO:0003323)2.39843454
125G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.39469262
126CENP-A containing nucleosome assembly (GO:0034080)2.39412656
127basement membrane organization (GO:0071711)2.37768987
128* protein folding (GO:0006457)2.36528794
129regulation of translational fidelity (GO:0006450)2.35465303
130antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.35356745
131UMP metabolic process (GO:0046049)2.35281412
132pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.35281412
133UMP biosynthetic process (GO:0006222)2.35281412
134pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.35281412
135DNA duplex unwinding (GO:0032508)2.34925465
136regulation of plasminogen activation (GO:0010755)2.34802806
137L-serine metabolic process (GO:0006563)2.33873546
138pentose-phosphate shunt (GO:0006098)2.33464790
139DNA topological change (GO:0006265)2.33249778
140gap junction assembly (GO:0016264)2.33098525
141cellular response to glucose starvation (GO:0042149)2.32725904
142regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.31082914
143NADPH regeneration (GO:0006740)2.30528101
144peptidyl-proline modification (GO:0018208)2.28663665
145misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.26935163
146folic acid-containing compound metabolic process (GO:0006760)2.25945417
147pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.25439354
148regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.24497023
149DNA unwinding involved in DNA replication (GO:0006268)2.23872613
150cellular response to ATP (GO:0071318)2.23656690
151L-alpha-amino acid transmembrane transport (GO:1902475)2.22845800
152nucleotide transmembrane transport (GO:1901679)2.22573855
153tricarboxylic acid metabolic process (GO:0072350)2.22021605
154regulation of lipoprotein particle clearance (GO:0010984)2.20450437
155positive regulation of receptor biosynthetic process (GO:0010870)2.20246932
156chaperone mediated protein folding requiring cofactor (GO:0051085)2.19618724
157serine family amino acid biosynthetic process (GO:0009070)2.18072818
158protein targeting to membrane (GO:0006612)2.18034246
159antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.18014806
160fucose metabolic process (GO:0006004)2.18000727
161one-carbon metabolic process (GO:0006730)2.17150382
162COPI coating of Golgi vesicle (GO:0048205)10.0069765
163Golgi transport vesicle coating (GO:0048200)10.0069765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.48061690
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.45807183
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.35632562
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30215114
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02788719
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.98465725
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.67504101
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.50045475
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.48885214
10ZNF263_19887448_ChIP-Seq_K562_Human2.41977338
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40383429
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.38675001
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35529247
14* CLOCK_20551151_ChIP-Seq_293T_Human2.35420445
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23802427
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.18498339
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13381346
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12393502
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.07376859
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05207291
21GATA1_22025678_ChIP-Seq_K562_Human2.03762721
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.02450340
23RXR_22158963_ChIP-Seq_LIVER_Mouse2.02276589
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.99494905
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.97735485
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97379969
27AR_21909140_ChIP-Seq_LNCAP_Human1.95325188
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95300956
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92599087
30DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.92266824
31DCP1A_22483619_ChIP-Seq_HELA_Human1.90419432
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88829954
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88161404
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84249851
35* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82945906
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.82655351
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79299685
38ELK1_19687146_ChIP-ChIP_HELA_Human1.72744927
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71286930
40XRN2_22483619_ChIP-Seq_HELA_Human1.70400343
41TFEB_21752829_ChIP-Seq_HELA_Human1.68837655
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.67791817
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67507778
44GABP_19822575_ChIP-Seq_HepG2_Human1.64467459
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.62486591
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61774854
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54455041
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53962424
49KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53535134
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.53480865
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.49130967
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48459929
53VDR_23849224_ChIP-Seq_CD4+_Human1.47722061
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46248490
55KDM5A_27292631_Chip-Seq_BREAST_Human1.46068816
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43033465
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41730884
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39642669
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39420060
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39333768
61* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39104595
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38371505
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37633901
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36026983
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34891509
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33975793
67* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32966177
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32371471
69FOXP3_21729870_ChIP-Seq_TREG_Human1.32115135
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31046430
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.30635221
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29061425
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.28903007
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28762026
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27615728
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25721103
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24433024
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24220833
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23825962
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.22994025
81SRF_21415370_ChIP-Seq_HL-1_Mouse1.22850964
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21382216
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21164539
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20389962
85SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.20193886
86MYC_22102868_ChIP-Seq_BL_Human1.19761048
87EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18918937
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18489329
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18104621
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17717850
91SOX17_20123909_ChIP-Seq_XEN_Mouse1.15678230
92TTF2_22483619_ChIP-Seq_HELA_Human1.15292574
93* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15287723
94ELK1_22589737_ChIP-Seq_MCF10A_Human1.14796888
95* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13825320
96CHD1_26751641_Chip-Seq_LNCaP_Human1.13757438
97NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11072619
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.11033018
99* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10795625
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09976576
101* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08792449
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08107762
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07464608
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05480545
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04356453
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03366798
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02725631
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02706695
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01187995
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01014017
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00833569
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99339341
113WT1_19549856_ChIP-ChIP_CCG9911_Human0.99075030
114TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97463910
115* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.97205185
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96858530
117ATF3_27146783_Chip-Seq_COLON_Human0.96424391
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95446245
119SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95330528
120RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95266207
121TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95104776
122* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94560118
123NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93449295
124THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93040959
125NANOG_16153702_ChIP-ChIP_HESCs_Human0.92983147
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92816419
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.90947437
128TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90739273
129GATA4_25053715_ChIP-Seq_YYC3_Human0.90540407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.78919789
2MP0006054_spinal_hemorrhage3.40551929
3MP0003941_abnormal_skin_development3.32483835
4MP0003111_abnormal_nucleus_morphology2.68982699
5MP0002139_abnormal_hepatobiliary_system2.63124442
6MP0003705_abnormal_hypodermis_morpholog2.59053806
7MP0002877_abnormal_melanocyte_morpholog2.55856726
8MP0005220_abnormal_exocrine_pancreas2.48736555
9MP0010094_abnormal_chromosome_stability2.47020871
10MP0003283_abnormal_digestive_organ2.24382969
11MP0004264_abnormal_extraembryonic_tissu2.12037227
12MP0004272_abnormal_basement_membrane2.10393873
13MP0005365_abnormal_bile_salt2.06216545
14MP0003693_abnormal_embryo_hatching2.06125646
15MP0010030_abnormal_orbit_morphology1.90695161
16MP0003806_abnormal_nucleotide_metabolis1.90331822
17MP0003300_gastrointestinal_ulcer1.85637793
18MP0009697_abnormal_copulation1.84714491
19MP0003566_abnormal_cell_adhesion1.76877554
20MP0001944_abnormal_pancreas_morphology1.76528679
21MP0001666_abnormal_nutrient_absorption1.73017183
22MP0005058_abnormal_lysosome_morphology1.71574710
23MP0010352_gastrointestinal_tract_polyps1.69038330
24MP0003195_calcinosis1.67294684
25MP0005275_abnormal_skin_tensile1.59515334
26MP0004957_abnormal_blastocyst_morpholog1.58002103
27MP0002693_abnormal_pancreas_physiology1.53864131
28MP0005360_urolithiasis1.52527255
29MP0009053_abnormal_anal_canal1.51291725
30MP0001672_abnormal_embryogenesis/_devel1.51021152
31MP0005380_embryogenesis_phenotype1.51021152
32MP0001849_ear_inflammation1.48757431
33MP0005623_abnormal_meninges_morphology1.46256817
34MP0003183_abnormal_peptide_metabolism1.38897618
35MP0005503_abnormal_tendon_morphology1.37136401
36MP0003950_abnormal_plasma_membrane1.37018973
37MP0000013_abnormal_adipose_tissue1.36689820
38MP0009643_abnormal_urine_homeostasis1.35772505
39MP0005408_hypopigmentation1.34785573
40MP0003252_abnormal_bile_duct1.34753734
41MP0005085_abnormal_gallbladder_physiolo1.34421137
42MP0008058_abnormal_DNA_repair1.32932873
43MP0004043_abnormal_pH_regulation1.32735454
44MP0009780_abnormal_chondrocyte_physiolo1.32683783
45MP0000537_abnormal_urethra_morphology1.32156270
46MP0002896_abnormal_bone_mineralization1.31600916
47MP0005083_abnormal_biliary_tract1.29652316
48MP0010234_abnormal_vibrissa_follicle1.28836234
49MP0009384_cardiac_valve_regurgitation1.27127293
50MP0002084_abnormal_developmental_patter1.26450759
51MP0003123_paternal_imprinting1.25879553
52MP0005023_abnormal_wound_healing1.25660498
53MP0002697_abnormal_eye_size1.24835834
54MP0001661_extended_life_span1.24833181
55MP0003315_abnormal_perineum_morphology1.24726358
56MP0002085_abnormal_embryonic_tissue1.22845565
57MP0010386_abnormal_urinary_bladder1.22818997
58MP0000678_abnormal_parathyroid_gland1.22274925
59MP0003385_abnormal_body_wall1.21120428
60MP0002295_abnormal_pulmonary_circulatio1.20005724
61MP0000613_abnormal_salivary_gland1.18077401
62MP0004233_abnormal_muscle_weight1.16845227
63MP0003186_abnormal_redox_activity1.16569980
64MP0005076_abnormal_cell_differentiation1.15957976
65MP0000762_abnormal_tongue_morphology1.13711543
66MP0003868_abnormal_feces_composition1.11941452
67MP0003122_maternal_imprinting1.10974106
68MP0002166_altered_tumor_susceptibility1.10272913
69MP0010307_abnormal_tumor_latency1.10058348
70MP0003937_abnormal_limbs/digits/tail_de1.08425034
71MP0005451_abnormal_body_composition1.08110466
72MP0004782_abnormal_surfactant_physiolog1.07564112
73MP0003718_maternal_effect1.07185382
74MP0001756_abnormal_urination1.03841400
75MP0003890_abnormal_embryonic-extraembry0.99774052
76MP0005197_abnormal_uvea_morphology0.99593807
77MP0008007_abnormal_cellular_replicative0.99323472
78MP0002089_abnormal_postnatal_growth/wei0.97992505
79MP0003279_aneurysm0.95976355
80MP0001299_abnormal_eye_distance/0.94401629
81MP0000358_abnormal_cell_content/0.93938005
82MP0002060_abnormal_skin_morphology0.93822455
83MP0008057_abnormal_DNA_replication0.93568061
84MP0002254_reproductive_system_inflammat0.93085217
85MP0008875_abnormal_xenobiotic_pharmacok0.92746631
86MP0002938_white_spotting0.92076679
87MP0000566_synostosis0.91618278
88MP0005501_abnormal_skin_physiology0.91463326
89MP0003567_abnormal_fetal_cardiomyocyte0.91142041
90MP0003172_abnormal_lysosome_physiology0.90865066
91MP0005332_abnormal_amino_acid0.90448651
92MP0010368_abnormal_lymphatic_system0.89661802
93MP0005384_cellular_phenotype0.89155426
94MP0000598_abnormal_liver_morphology0.88938340
95MP0005621_abnormal_cell_physiology0.88711432
96MP0009840_abnormal_foam_cell0.88101365
97MP0003959_abnormal_lean_body0.87988177
98MP0002092_abnormal_eye_morphology0.87901100
99MP0008260_abnormal_autophagy0.87595695
100MP0001730_embryonic_growth_arrest0.86413842
101MP0005257_abnormal_intraocular_pressure0.86317762
102MP0001764_abnormal_homeostasis0.85933482
103MP0000428_abnormal_craniofacial_morphol0.85712899
104MP0010329_abnormal_lipoprotein_level0.85311619
105MP0004197_abnormal_fetal_growth/weight/0.85174985
106MP0002796_impaired_skin_barrier0.84602250
107MP0003115_abnormal_respiratory_system0.84515732
108MP0000462_abnormal_digestive_system0.84047567
109MP0000681_abnormal_thyroid_gland0.83938657
110MP0005636_abnormal_mineral_homeostasis0.83318010
111MP0002078_abnormal_glucose_homeostasis0.83291839
112MP0000163_abnormal_cartilage_morphology0.83035213
113MP0000609_abnormal_liver_physiology0.82947934
114MP0003942_abnormal_urinary_system0.82426563
115MP0005319_abnormal_enzyme/_coenzyme0.82023158
116MP0005508_abnormal_skeleton_morphology0.81971891
117MP0005310_abnormal_salivary_gland0.81400853
118MP0003786_premature_aging0.80660853
119MP0003795_abnormal_bone_structure0.80298604
120MP0004858_abnormal_nervous_system0.79287515
121MP0001293_anophthalmia0.78051412
122MP0001243_abnormal_dermal_layer0.77308916
123MP0005330_cardiomyopathy0.77229927
124MP0000858_altered_metastatic_potential0.76754986
125MP0001958_emphysema0.76363898
126MP0001915_intracranial_hemorrhage0.75362698
127MP0000003_abnormal_adipose_tissue0.74930900
128MP0002111_abnormal_tail_morphology0.74815248
129MP0000313_abnormal_cell_death0.74546898
130MP0005379_endocrine/exocrine_gland_phen0.74419002
131MP0001881_abnormal_mammary_gland0.73876921
132MP0003077_abnormal_cell_cycle0.73236863
133MP0000627_abnormal_mammary_gland0.73201870
134MP0002233_abnormal_nose_morphology0.72819404
135MP0008932_abnormal_embryonic_tissue0.72123679
136MP0003191_abnormal_cellular_cholesterol0.71594369
137MP0001533_abnormal_skeleton_physiology0.71310882
138MP0002909_abnormal_adrenal_gland0.70756137
139MP0002080_prenatal_lethality0.69105815
140MP0002138_abnormal_hepatobiliary_system0.68408764
141MP0002135_abnormal_kidney_morphology0.68338416
142MP0009672_abnormal_birth_weight0.68207355
143MP0001697_abnormal_embryo_size0.67211957
144MP0002086_abnormal_extraembryonic_tissu0.66629843
145MP0002088_abnormal_embryonic_growth/wei0.66595098
146MP0001765_abnormal_ion_homeostasis0.66428023
147MP0000350_abnormal_cell_proliferation0.66419963
148MP0003984_embryonic_growth_retardation0.65928092
149MP0005084_abnormal_gallbladder_morpholo0.64094141

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the intrinsic pathway (HP:0010989)4.66024526
2Hypoglycemic coma (HP:0001325)4.43108498
3Hypoglycemic seizures (HP:0002173)3.82643944
4Hyperinsulinemic hypoglycemia (HP:0000825)3.81346707
5Cervical subluxation (HP:0003308)3.45913410
6Abnormality of the common coagulation pathway (HP:0010990)3.42567132
7Abnormality of glycolysis (HP:0004366)3.38334542
8Protrusio acetabuli (HP:0003179)3.35383007
9Abnormality of endocrine pancreas physiology (HP:0012093)3.34750871
10Abnormality of the pancreatic islet cells (HP:0006476)3.34750871
11Premature rupture of membranes (HP:0001788)3.33694834
12Thrombocytosis (HP:0001894)3.26265886
13Vacuolated lymphocytes (HP:0001922)3.23173142
14Increased serum pyruvate (HP:0003542)3.19805249
15Generalized aminoaciduria (HP:0002909)3.17515188
16Symptomatic seizures (HP:0011145)3.15212347
17Mucopolysacchariduria (HP:0008155)3.09762298
18Urinary glycosaminoglycan excretion (HP:0003541)3.09762298
19Beaking of vertebral bodies (HP:0004568)2.92846588
20Pancreatic islet-cell hyperplasia (HP:0004510)2.87342871
21Dysostosis multiplex (HP:0000943)2.85665359
22Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.77167721
23Abnormal protein N-linked glycosylation (HP:0012347)2.77167721
24Abnormal protein glycosylation (HP:0012346)2.77167721
25Abnormal glycosylation (HP:0012345)2.77167721
26Small epiphyses (HP:0010585)2.72348731
27Thoracolumbar scoliosis (HP:0002944)2.72001568
28Abnormality of monocarboxylic acid metabolism (HP:0010996)2.67078032
29Ketoacidosis (HP:0001993)2.66248676
30Nonimmune hydrops fetalis (HP:0001790)2.64370513
31Intrahepatic cholestasis (HP:0001406)2.61564614
32Hypoplasia of the capital femoral epiphysis (HP:0003090)2.60997424
33Abnormality of mucopolysaccharide metabolism (HP:0011020)2.59843557
34Abnormality of polysaccharide metabolism (HP:0011012)2.59843557
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.59843557
36Abnormality of carpal bone ossification (HP:0006257)2.59698178
37Abnormal gallbladder physiology (HP:0012438)2.56968707
38Cholecystitis (HP:0001082)2.56968707
39Abnormal pancreas size (HP:0012094)2.50737589
40Type I transferrin isoform profile (HP:0003642)2.49591014
41Hyperglycemia (HP:0003074)2.47434677
42Asymmetry of the thorax (HP:0001555)2.45340570
43Late onset (HP:0003584)2.44717381
44Abnormal foot bone ossification (HP:0010675)2.41957437
45Abnormal delivery (HP:0001787)2.37934271
46Abnormality of aromatic amino acid family metabolism (HP:0004338)2.37864981
47Pterygium (HP:0001059)2.33116436
48Selective tooth agenesis (HP:0001592)2.29990963
4911 pairs of ribs (HP:0000878)2.28800219
50Abnormality of dentin (HP:0010299)2.28435000
51Reduced antithrombin III activity (HP:0001976)2.27722623
52Increased nuchal translucency (HP:0010880)2.25909148
53Cerebral aneurysm (HP:0004944)2.25173017
54Renal duplication (HP:0000075)2.21225892
55Back pain (HP:0003418)2.21035835
56Missing ribs (HP:0000921)2.20746173
57Breech presentation (HP:0001623)2.20343819
58Aortic aneurysm (HP:0004942)2.20257938
59Abnormality of the anterior horn cell (HP:0006802)2.19896669
60Degeneration of anterior horn cells (HP:0002398)2.19896669
61Deep venous thrombosis (HP:0002625)2.18960676
62Hypobetalipoproteinemia (HP:0003563)2.17379770
63Deviation of the thumb (HP:0009603)2.16699075
64Aortic dissection (HP:0002647)2.16260554
65Ketosis (HP:0001946)2.15286130
66Fat malabsorption (HP:0002630)2.15156531
67Microglossia (HP:0000171)2.13561840
68Platyspondyly (HP:0000926)2.13476202
69Overlapping toe (HP:0001845)2.12819930
70Absent epiphyses (HP:0010577)2.11134974
71Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.11134974
72Abnormality of the umbilical cord (HP:0010881)2.10630403
73Atrophic scars (HP:0001075)2.10385757
74Hand muscle atrophy (HP:0009130)2.10311731
75Trismus (HP:0000211)2.09835171
76Soft skin (HP:0000977)2.09576565
77Flat acetabular roof (HP:0003180)2.08410757
78Orthostatic hypotension (HP:0001278)2.05881654
79Severe short stature (HP:0003510)2.04583180
80Microvesicular hepatic steatosis (HP:0001414)2.03867434
81Insulin resistance (HP:0000855)2.03619620
82Abnormalities of placenta or umbilical cord (HP:0001194)2.03039419
83Abnormal ossification of hand bones (HP:0005921)2.03018854
84Aplastic anemia (HP:0001915)2.02432728
85Abnormal tarsal ossification (HP:0008369)2.01471720
86Blue sclerae (HP:0000592)2.00973309
87Hypoplasia of the pons (HP:0012110)2.00717496
88Abdominal distention (HP:0003270)2.00664546
89Osteolytic defects of the hand bones (HP:0009699)1.97936515
90Osteolytic defects of the phalanges of the hand (HP:0009771)1.97936515
91Arterial tortuosity (HP:0005116)1.97733107
92Abnormal cartilage morphology (HP:0002763)1.95974357
93Protuberant abdomen (HP:0001538)1.95703072
94Hypolipoproteinemia (HP:0010981)1.94705355
95Proximal placement of thumb (HP:0009623)1.94658730
96Ankyloglossia (HP:0010296)1.93892912
97Epiphyseal dysplasia (HP:0002656)1.91645158
98Conjugated hyperbilirubinemia (HP:0002908)1.91579799
99Joint stiffness (HP:0001387)1.91428802
100Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90406731
101Wormian bones (HP:0002645)1.90248627
102Short nail (HP:0001799)1.88024793
103Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.87746583
104Vertebral hypoplasia (HP:0008417)1.87746583
105Metaphyseal cupping (HP:0003021)1.86553934
106Abnormality of the calcaneus (HP:0008364)1.86081383
107Vertebral compression fractures (HP:0002953)1.85622972
108Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85284817
109Abnormality of methionine metabolism (HP:0010901)1.84886401
110Vascular tortuosity (HP:0004948)1.84562589
111Nephroblastoma (Wilms tumor) (HP:0002667)1.83962866
112Prominent metopic ridge (HP:0005487)1.82698499
113Prolonged partial thromboplastin time (HP:0003645)1.82386727
114Bladder diverticulum (HP:0000015)1.82298631
115Aneurysm (HP:0002617)1.82245580
116Single umbilical artery (HP:0001195)1.81877782
117Abnormality of the fetal cardiovascular system (HP:0010948)1.81877782
118Abnormal umbilical cord blood vessels (HP:0011403)1.81877782
119Spastic diplegia (HP:0001264)1.81871655
120Abnormality of the acetabulum (HP:0003170)1.81511560
121Hypercholesterolemia (HP:0003124)1.81395906
122Abnormality of oral frenula (HP:0000190)1.79509920
123Coxa valga (HP:0002673)1.78900834
124Elevated alkaline phosphatase (HP:0003155)1.78469566
125Cardiovascular calcification (HP:0011915)1.78128371
126Multiple enchondromatosis (HP:0005701)1.78078886
127Abnormality of pain sensation (HP:0010832)1.77007350
128Impaired pain sensation (HP:0007328)1.77007350
129Elbow flexion contracture (HP:0002987)1.76793766
130Ulnar bowing (HP:0003031)1.76581823
131Chromsome breakage (HP:0040012)1.76502432
132Abnormality of the pons (HP:0007361)1.76312751
133Embryonal renal neoplasm (HP:0011794)1.76002429
134Disproportionate short-trunk short stature (HP:0003521)1.75795840
135Abnormality of subcutaneous fat tissue (HP:0001001)1.74463104
136Abnormal hand bone ossification (HP:0010660)1.73351695
137Steatorrhea (HP:0002570)1.72724346
138Abnormality of alkaline phosphatase activity (HP:0004379)1.72295030
139Abnormal enzyme/coenzyme activity (HP:0012379)1.72237233
140Vascular calcification (HP:0004934)1.71236526
141Exocrine pancreatic insufficiency (HP:0001738)1.70494258
142Xanthomatosis (HP:0000991)1.70147387
143Secondary amenorrhea (HP:0000869)1.69998401
144Poor head control (HP:0002421)1.69864111
145Insulin-resistant diabetes mellitus (HP:0000831)1.69260227
146Rough bone trabeculation (HP:0100670)1.68666571
147Delayed cranial suture closure (HP:0000270)1.67765930
148Right ventricular cardiomyopathy (HP:0011663)1.67566685
149Peritonitis (HP:0002586)1.67525959
150Biconcave vertebral bodies (HP:0004586)1.67425343
151Fragile skin (HP:0001030)1.66455944
152Ankle contracture (HP:0006466)1.66149431
153Abnormal biliary tract morphology (HP:0012440)1.66126544
154Large for gestational age (HP:0001520)1.63878574
155Wide nose (HP:0000445)1.63567943
156Abnormality of the Achilles tendon (HP:0005109)1.61606948
157Skin nodule (HP:0200036)1.60131650
158Natal tooth (HP:0000695)1.59837980
159Abnormality of the lumbar spine (HP:0100712)1.59632735
160Vaginal fistula (HP:0004320)1.59467128
161Irregular epiphyses (HP:0010582)1.58534713
162Abnormal lung lobation (HP:0002101)1.57876739
163Wide cranial sutures (HP:0010537)1.57304675
164Pancreatitis (HP:0001733)1.57093281
165Hypoplasia of the odontoid process (HP:0003311)1.56062406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.85835263
2PASK3.75032457
3SCYL22.84470792
4BCKDK2.82056014
5TAOK32.80963184
6PBK2.77163833
7EIF2AK32.53741287
8FLT32.51251064
9FRK2.43840792
10PKN22.41027254
11INSRR2.34784172
12TRIB32.30578801
13VRK22.06809080
14EPHA22.02438968
15SMG11.90271876
16TESK11.89412599
17LATS11.88382659
18AKT31.80683950
19LATS21.80294247
20BRSK21.77968362
21SIK11.64071297
22TSSK61.61549958
23EIF2AK11.56747698
24ERBB41.55280996
25NME21.51717271
26PTK61.50885608
27PDGFRA1.48969601
28MST41.48904570
29PIK3CG1.45586659
30TGFBR11.38753101
31PAK41.36234628
32RPS6KB21.33471777
33CDK121.31190919
34EEF2K1.31029137
35TESK21.30489003
36MAP3K31.30377460
37MKNK11.29173882
38MET1.26600934
39NEK91.26539225
40BUB11.24180540
41NTRK11.23261011
42PLK41.21402262
43LRRK21.18890590
44ICK1.12877888
45WEE11.07745572
46MAPK151.05839527
47BCR1.03715996
48PDK21.00836648
49KDR0.96145806
50ARAF0.95641656
51MAP3K120.93082015
52IRAK30.91006046
53PAK20.89847301
54TAF10.89176658
55CDK60.87577892
56MAP3K80.86880666
57PTK20.85068320
58TTN0.84657066
59DDR20.83802257
60MAP2K30.83770613
61FER0.82664106
62CHEK20.82112550
63STK100.80845037
64STK160.80076858
65STK30.79549318
66MAPKAPK30.79333925
67NME10.77529530
68CHEK10.77473965
69MAP3K20.76553046
70MAP3K100.76219761
71LIMK10.74525701
72RPS6KA40.74450575
73EPHA30.74394180
74CDC70.73092784
75AURKB0.71178845
76PIM20.69908029
77STK38L0.68906848
78CLK10.68785696
79CDK70.68588585
80BTK0.68375001
81NUAK10.67061367
82FGFR40.65484484
83ALK0.64709696
84PRKCI0.64542015
85MKNK20.63067344
86LMTK20.61757949
87TRIM280.60387354
88JAK30.60192562
89MST1R0.59821441
90MAP2K20.59760614
91EIF2AK20.59605717
92MYLK0.59116928
93HIPK20.58550163
94ACVR1B0.56593151
95MTOR0.56544687
96CDK40.55831588
97MAP3K90.52479434
98VRK10.52104830
99IRAK40.51521060
100CDK90.51484047
101ATM0.51010871
102ATR0.47996249
103BMX0.47643011
104ILK0.47157999
105FGFR30.47074743
106FGFR10.46861634
107NEK20.46746336
108STK40.46068712
109PLK20.45994454
110TEC0.44902871
111BRAF0.44833989
112PLK30.44569937
113TTK0.43821014
114CSF1R0.43216629
115SRPK10.43027725
116MELK0.42795107
117EPHB20.42771581
118CDK180.42545976
119BRSK10.42367893
120ERBB30.42267692
121AKT20.42247744
122TGFBR20.41658248
123ZAP700.41271197
124RPS6KA20.40603267
125PLK10.39434617
126TYK20.39278416
127RPS6KL10.38996834
128RPS6KC10.38996834
129ABL20.38012499
130DYRK1B0.37744317
131TRPM70.37731424
132CSNK2A20.37430193
133NEK10.35244167
134JAK20.35137016
135AURKA0.33941208
136CDK80.33696451
137RPS6KA60.33020905
138TIE10.31431234

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.89159546
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.24705417
3* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.05723804
4Sulfur metabolism_Homo sapiens_hsa009202.96634438
5N-Glycan biosynthesis_Homo sapiens_hsa005102.80564935
6Selenocompound metabolism_Homo sapiens_hsa004502.23091736
7One carbon pool by folate_Homo sapiens_hsa006702.20137872
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06585419
9Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.87547190
10Other glycan degradation_Homo sapiens_hsa005111.82015975
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81686374
12DNA replication_Homo sapiens_hsa030301.61886505
13Proteasome_Homo sapiens_hsa030501.50324176
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49207332
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48763132
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48075603
17Antigen processing and presentation_Homo sapiens_hsa046121.45909376
18Vitamin B6 metabolism_Homo sapiens_hsa007501.42009299
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41373679
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.38615683
21Vibrio cholerae infection_Homo sapiens_hsa051101.38487253
22Tryptophan metabolism_Homo sapiens_hsa003801.34324618
23Galactose metabolism_Homo sapiens_hsa000521.26239589
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26223067
25Folate biosynthesis_Homo sapiens_hsa007901.24886026
26Lysosome_Homo sapiens_hsa041421.22167141
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18929127
28Mismatch repair_Homo sapiens_hsa034301.18901537
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17204438
30Fatty acid degradation_Homo sapiens_hsa000711.15385457
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.14783830
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.13652029
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07402414
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.06240901
35Legionellosis_Homo sapiens_hsa051341.05958474
36Renin-angiotensin system_Homo sapiens_hsa046141.05509646
37Biosynthesis of amino acids_Homo sapiens_hsa012301.01322974
38Complement and coagulation cascades_Homo sapiens_hsa046101.01232657
39Starch and sucrose metabolism_Homo sapiens_hsa005001.00904611
40Ribosome_Homo sapiens_hsa030100.97415363
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96136071
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94166836
43Nucleotide excision repair_Homo sapiens_hsa034200.93590953
44Fat digestion and absorption_Homo sapiens_hsa049750.93535048
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92127381
46Base excision repair_Homo sapiens_hsa034100.90868167
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90411903
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90400759
49Protein digestion and absorption_Homo sapiens_hsa049740.89305201
50mRNA surveillance pathway_Homo sapiens_hsa030150.88770454
51Carbon metabolism_Homo sapiens_hsa012000.87663695
52Adherens junction_Homo sapiens_hsa045200.87274397
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.86536742
54RNA transport_Homo sapiens_hsa030130.85735582
55ECM-receptor interaction_Homo sapiens_hsa045120.82471409
56Vitamin digestion and absorption_Homo sapiens_hsa049770.81415580
57Thyroid hormone synthesis_Homo sapiens_hsa049180.81229853
58Bladder cancer_Homo sapiens_hsa052190.80528503
59Glutathione metabolism_Homo sapiens_hsa004800.77225440
60Pyrimidine metabolism_Homo sapiens_hsa002400.77009500
61Arginine and proline metabolism_Homo sapiens_hsa003300.75848987
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75579006
63Spliceosome_Homo sapiens_hsa030400.75267745
64Propanoate metabolism_Homo sapiens_hsa006400.75194542
65Histidine metabolism_Homo sapiens_hsa003400.74936980
66Fructose and mannose metabolism_Homo sapiens_hsa000510.73750171
67Non-homologous end-joining_Homo sapiens_hsa034500.73549274
68Pyruvate metabolism_Homo sapiens_hsa006200.72425347
69Sulfur relay system_Homo sapiens_hsa041220.70892569
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.69997454
71Peroxisome_Homo sapiens_hsa041460.69424900
72Fanconi anemia pathway_Homo sapiens_hsa034600.63217699
73Proteoglycans in cancer_Homo sapiens_hsa052050.63031566
74Phenylalanine metabolism_Homo sapiens_hsa003600.59864456
75Cell cycle_Homo sapiens_hsa041100.58745731
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58651299
77Tyrosine metabolism_Homo sapiens_hsa003500.58239849
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57910829
79Fatty acid metabolism_Homo sapiens_hsa012120.56953583
80Phagosome_Homo sapiens_hsa041450.56058149
81Pentose phosphate pathway_Homo sapiens_hsa000300.54362217
82Small cell lung cancer_Homo sapiens_hsa052220.53890071
83TGF-beta signaling pathway_Homo sapiens_hsa043500.53579939
84Purine metabolism_Homo sapiens_hsa002300.52457165
85Prostate cancer_Homo sapiens_hsa052150.52385216
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51870434
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51834088
88Hippo signaling pathway_Homo sapiens_hsa043900.51000338
89Focal adhesion_Homo sapiens_hsa045100.50425954
90Prion diseases_Homo sapiens_hsa050200.50401468
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50166363
92RNA degradation_Homo sapiens_hsa030180.49347335
93Lysine degradation_Homo sapiens_hsa003100.48626397
94Caffeine metabolism_Homo sapiens_hsa002320.46758240
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46194874
96Thyroid cancer_Homo sapiens_hsa052160.46155820
97MicroRNAs in cancer_Homo sapiens_hsa052060.46004022
98Chemical carcinogenesis_Homo sapiens_hsa052040.42886056
99Steroid biosynthesis_Homo sapiens_hsa001000.42349579
100Arginine biosynthesis_Homo sapiens_hsa002200.40444426
101Metabolic pathways_Homo sapiens_hsa011000.40290253
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39857630
103Viral carcinogenesis_Homo sapiens_hsa052030.38923947
104beta-Alanine metabolism_Homo sapiens_hsa004100.38050863
105Homologous recombination_Homo sapiens_hsa034400.37570981
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37287616
107p53 signaling pathway_Homo sapiens_hsa041150.36759510
108Insulin resistance_Homo sapiens_hsa049310.36594835
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36421204
110RNA polymerase_Homo sapiens_hsa030200.36390872
111Butanoate metabolism_Homo sapiens_hsa006500.36158516
112Fatty acid elongation_Homo sapiens_hsa000620.35038274
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34118159
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33843129
115Type I diabetes mellitus_Homo sapiens_hsa049400.33821600
116Amoebiasis_Homo sapiens_hsa051460.33470441
117Shigellosis_Homo sapiens_hsa051310.33132697
118Basal cell carcinoma_Homo sapiens_hsa052170.32707680
119Sphingolipid metabolism_Homo sapiens_hsa006000.32280494
120Systemic lupus erythematosus_Homo sapiens_hsa053220.30887244
121Fatty acid biosynthesis_Homo sapiens_hsa000610.30809853
122Tight junction_Homo sapiens_hsa045300.30533793
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30253019

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